Search of human proteins with 118600963

Search of human proteins with 118600963

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118600963 Nik related kinase [Homo sapiens]
         (1582 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118600963 Nik related kinase [Homo sapiens]                       3184   0.0  
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...   419   e-116
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...   412   e-114
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...   412   e-114
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...   409   e-113
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...   409   e-113
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]     408   e-113
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...   406   e-113
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...   406   e-113
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]     405   e-112
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]     405   e-112
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]      405   e-112
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...   405   e-112
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   402   e-111
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   400   e-111
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   400   e-111
gi|145275208 myosin IIIA [Homo sapiens]                               255   2e-67
gi|134288915 myosin IIIB isoform 1 [Homo sapiens]                     251   4e-66
gi|134288892 myosin IIIB isoform 2 [Homo sapiens]                     251   4e-66
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                  206   1e-52
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   206   1e-52
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   206   1e-52
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 202   2e-51
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   202   2e-51
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...   202   2e-51
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 201   6e-51
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                199   2e-50
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   199   2e-50
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   199   2e-50
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   198   3e-50

>gi|118600963 Nik related kinase [Homo sapiens]
          Length = 1582

 Score = 3184 bits (8255), Expect = 0.0
 Identities = 1582/1582 (100%), Positives = 1582/1582 (100%)

Query: 1    MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
            MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK
Sbjct: 1    MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60

Query: 61   TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
            TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG
Sbjct: 61   TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120

Query: 121  QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
            QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG
Sbjct: 121  QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180

Query: 181  QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
            QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV
Sbjct: 181  QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240

Query: 241  WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
            WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF
Sbjct: 241  WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300

Query: 301  RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
            RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR
Sbjct: 301  RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360

Query: 361  FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420
            FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ
Sbjct: 361  FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420

Query: 421  ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP 480
            ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP
Sbjct: 421  ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP 480

Query: 481  LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ 540
            LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
Sbjct: 481  LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ 540

Query: 541  RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL 600
            RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL
Sbjct: 541  RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL 600

Query: 601  PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG 660
            PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG
Sbjct: 601  PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG 660

Query: 661  PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL 720
            PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL
Sbjct: 661  PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL 720

Query: 721  EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK 780
            EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK
Sbjct: 721  EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK 780

Query: 781  KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS 840
            KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS
Sbjct: 781  KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS 840

Query: 841  SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF 900
            SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF
Sbjct: 841  SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF 900

Query: 901  RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD 960
            RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD
Sbjct: 901  RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD 960

Query: 961  QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG 1020
            QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG
Sbjct: 961  QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG 1020

Query: 1021 SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE 1080
            SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE
Sbjct: 1021 SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE 1080

Query: 1081 ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ 1140
            ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ
Sbjct: 1081 ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ 1140

Query: 1141 SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL 1200
            SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL
Sbjct: 1141 SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL 1200

Query: 1201 IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN 1260
            IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN
Sbjct: 1201 IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN 1260

Query: 1261 LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL 1320
            LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL
Sbjct: 1261 LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL 1320

Query: 1321 QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ 1380
            QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ
Sbjct: 1321 QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ 1380

Query: 1381 AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES 1440
            AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES
Sbjct: 1381 AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES 1440

Query: 1441 EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI 1500
            EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI
Sbjct: 1441 EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI 1500

Query: 1501 PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN 1560
            PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN
Sbjct: 1501 PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN 1560

Query: 1561 HHSRVYFMTLGKLEELQSNYDV 1582
            HHSRVYFMTLGKLEELQSNYDV
Sbjct: 1561 HHSRVYFMTLGKLEELQSNYDV 1582


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score =  419 bits (1077), Expect = e-116
 Identities = 325/989 (32%), Positives = 468/989 (47%), Gaps = 132/989 (13%)

Query: 14  DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
           DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +             
Sbjct: 14  DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60

Query: 74  KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
                      DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG   QLW+VME C 
Sbjct: 61  -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109

Query: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
           AGS+TD+V+ T   +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169

Query: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
           VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+WS GITAIEMAEG
Sbjct: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229

Query: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           APPLC++ P+ ALF+I R   P +KS  WS+KF +F+E C +KN++ RP++  +L+HPF+
Sbjct: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289

Query: 314 RDIKNERHVVESLTRHLTGIIKKRQKKG-----IPLIFEREEAIKEQYTVRRFRGPSCTH 368
           RD  NER V   L  H+    KKR +K           E EE + EQ             
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQ------------- 336

Query: 369 ELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKP 428
                             GEPS    +P                 R F+ LQ      + 
Sbjct: 337 -----------------EGEPSSIVNVPGEST-----------LRRDFLRLQ------QE 362

Query: 429 LKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAP 488
            K +++A +R Q      +  Q + K +     Q +I+     RR       L+ Q R  
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR------LEEQQRRE 416

Query: 489 RLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP--------EQQQ 540
           R  + Q +  ++++ Q +    ++L++  +E + + +  E++R+ +          E++Q
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476

Query: 541 RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL 600
           RH +V +Q+L Q    EQ  + E      +   +AE  +      Q +L  L  DH    
Sbjct: 477 RHLEVLQQQLLQ----EQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPH 532

Query: 601 PLHLDTQVLIPVEGQTEGS---PQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSK 657
           P H   Q   P + +++ S   P+ +A   EP      V+      +     A +    +
Sbjct: 533 PQH-SQQPPPPQQERSKPSFHAPEPKA-HYEPADRAREVEDRFRKTNHSSPEAQSKQTGR 590

Query: 658 PL-GPLQTLMENLSSNRFYS-QPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKL 715
            L  P+ +  E+ S+    S  P   R  + +V     A  K       R+ S       
Sbjct: 591 VLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHS------- 643

Query: 716 ELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPY 775
             SD   +      R +D       E+     D + E+ D  +   S     ++ P  P 
Sbjct: 644 -FSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPV 702

Query: 776 ISNPKKIEVQER-SPSVPNNQDH--AHHVKFSSSVPQRSLLEQAQKPI---DIRQRSSQN 829
            +  +   +  R SP   + Q +  A     +SS+  R L E+ +K +        S  +
Sbjct: 703 RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS 762

Query: 830 RQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNE 889
                  S   S+  S    R   SS    +  Q+L   +  P+  K  ++  P+    E
Sbjct: 763 NSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKK--EVFRPLKPAGE 820

Query: 890 WVGYNALSEIFRNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDD-------DESNDTF 942
            V   AL++  R         ++PP +  DY    + S  TD +DD       DES    
Sbjct: 821 -VDLTALAKELR-----AVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGP 874

Query: 943 EDTYDHANGNDDLDNQVDQANDVCKDHDD 971
           EDT   A  + +L N   ++      HDD
Sbjct: 875 EDT--RAASSLNLSNGETESVKTMIVHDD 901



 Score =  280 bits (717), Expect = 6e-75
 Identities = 155/424 (36%), Positives = 238/424 (56%), Gaps = 58/424 (13%)

Query: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
            SPS G+ +++   F+   +    +   ++  ++ S VNVNP    P    P I  Y+K F
Sbjct: 949  SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 1006

Query: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
             SEI C +LWGVNLL+GT S L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG 
Sbjct: 1007 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 1066

Query: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
            K++LRVY+L+WLRNKIL+NDPE +++Q            +  L GC H+ V+++E   ++
Sbjct: 1067 KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 1118

Query: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
             IALKSS+ +YAWAPK                                       P ++F
Sbjct: 1119 VIALKSSVEVYAWAPK---------------------------------------PYHKF 1139

Query: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
                     +  K F  L HKP+ VDL +   +RLK+ + S  G+H +D +S  + D+ L
Sbjct: 1140 ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1190

Query: 1449 PKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFEC 1508
            P +    I P  IIILP+  G+ +++ +  E + V    ++ K ++  W ++P+S+A+  
Sbjct: 1191 PTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1250

Query: 1509 TQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFM 1568
            + +T GWG+KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+VYFM
Sbjct: 1251 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1310

Query: 1569 TLGK 1572
            TLG+
Sbjct: 1311 TLGR 1314


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score =  412 bits (1059), Expect = e-114
 Identities = 268/729 (36%), Positives = 392/729 (53%), Gaps = 68/729 (9%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQV-RAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQ 534
                ++ Q+    R L++  Q    +QA     + + L++  +  + Q Q+ +Q+R   
Sbjct: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQL-KQERDYL 500

Query: 535 APEQQQRHNQVPEQE-----LEQNQAP-EQPEVQEQAAEPAQAETEAEEPESLRVNAQVF 588
              Q QR  Q P ++      ++  +P E+P   ++  E ++   ++      +V  ++ 
Sbjct: 501 VSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRIS 560

Query: 589 LPLL--------------SQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIG 634
            P L              ++   +L P+      L+ V+ Q      +Q+   +P + + 
Sbjct: 561 DPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLS 620

Query: 635 SVQALIEGLS-RDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLR 692
             Q  +   S R  +   NS+ +    PL T +E    + +  Q E    K   + +++ 
Sbjct: 621 GFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSIS 680

Query: 693 QALAKRLSP 701
            ALA++ SP
Sbjct: 681 PALARKNSP 689



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 989  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1046

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1047 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1106

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1107 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1158

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1159 EIYAWAPK---------------------------------------PYHKF-------- 1171

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1172 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1230

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1231 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1290

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1291 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1346



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKE 750
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score =  412 bits (1059), Expect = e-114
 Identities = 268/729 (36%), Positives = 392/729 (53%), Gaps = 68/729 (9%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQV-RAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQ 534
                ++ Q+    R L++  Q    +QA     + + L++  +  + Q Q+ +Q+R   
Sbjct: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQL-KQERDYL 500

Query: 535 APEQQQRHNQVPEQE-----LEQNQAP-EQPEVQEQAAEPAQAETEAEEPESLRVNAQVF 588
              Q QR  Q P ++      ++  +P E+P   ++  E ++   ++      +V  ++ 
Sbjct: 501 VSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRIS 560

Query: 589 LPLL--------------SQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIG 634
            P L              ++   +L P+      L+ V+ Q      +Q+   +P + + 
Sbjct: 561 DPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLS 620

Query: 635 SVQALIEGLS-RDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLR 692
             Q  +   S R  +   NS+ +    PL T +E    + +  Q E    K   + +++ 
Sbjct: 621 GFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSIS 680

Query: 693 QALAKRLSP 701
            ALA++ SP
Sbjct: 681 PALARKNSP 689



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 997  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1054

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1055 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1114

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1115 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1166

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1167 EIYAWAPK---------------------------------------PYHKF-------- 1179

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1180 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1238

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1239 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1298

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1299 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1354



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKE 750
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score =  409 bits (1050), Expect = e-113
 Identities = 268/717 (37%), Positives = 386/717 (53%), Gaps = 73/717 (10%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ----- 530
                   Q    + L+ Q Q    ++ Q Q  + +D   V  + Q Q+Q P ++     
Sbjct: 442 ------HEQEYKRKQLEEQRQA---ERLQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYH 491

Query: 531 -RQGQAPEQQQRHNQVPEQ--ELEQNQAPEQP-EVQEQAAEPAQAETEAEEPESLRVNAQ 586
            ++G +P ++    +  E+   L +  +P  P +V  + ++P         P S   +  
Sbjct: 492 YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL------PPRSESFSIS 545

Query: 587 VFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-R 645
              P  ++   +L P+      L+ V+ Q      +Q+   +P + +   Q  +   S R
Sbjct: 546 GVQP--ARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 603

Query: 646 DLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
             +   NS+ +    PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 604 VEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 960  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1017

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1018 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1077

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1078 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1129

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1130 EIYAWAPK---------------------------------------PYHKF-------- 1142

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1143 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1201

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1202 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1261

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1262 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1317



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 41/190 (21%), Positives = 81/190 (42%), Gaps = 21/190 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457

Query: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI 822
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++    +     ++
Sbjct: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK-----EV 508

Query: 823 RQRSSQNRQN 832
            +RS  NRQ+
Sbjct: 509 EERSRLNRQS 518


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score =  409 bits (1050), Expect = e-113
 Identities = 268/717 (37%), Positives = 386/717 (53%), Gaps = 73/717 (10%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ----- 530
                   Q    + L+ Q Q    ++ Q Q  + +D   V  + Q Q+Q P ++     
Sbjct: 442 ------HEQEYKRKQLEEQRQA---ERLQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYH 491

Query: 531 -RQGQAPEQQQRHNQVPEQ--ELEQNQAPEQP-EVQEQAAEPAQAETEAEEPESLRVNAQ 586
            ++G +P ++    +  E+   L +  +P  P +V  + ++P         P S   +  
Sbjct: 492 YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL------PPRSESFSIS 545

Query: 587 VFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-R 645
              P  ++   +L P+      L+ V+ Q      +Q+   +P + +   Q  +   S R
Sbjct: 546 GVQP--ARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 603

Query: 646 DLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
             +   NS+ +    PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 604 VEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 968  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1025

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1026 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1085

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1086 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1137

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1138 EIYAWAPK---------------------------------------PYHKF-------- 1150

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1151 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1209

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1210 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1269

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1270 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1325



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 41/190 (21%), Positives = 81/190 (42%), Gaps = 21/190 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457

Query: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI 822
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++    +     ++
Sbjct: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK-----EV 508

Query: 823 RQRSSQNRQN 832
            +RS  NRQ+
Sbjct: 509 EERSRLNRQS 518


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score =  408 bits (1048), Expect = e-113
 Identities = 260/673 (38%), Positives = 365/673 (54%), Gaps = 75/673 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           M  P   R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +
Sbjct: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61  ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+V+ T   +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 97  NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R   P +KS  WS+KF +F++ C IK +L 
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +L+ PF+RD   ER V   L  H   I + R+K+G     E+EE  + +Y+   
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327

Query: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420
               S                    HGE  +P  +     P    L+      R F+ LQ
Sbjct: 328 EEDDS--------------------HGEEGEPSSI--MNVPGESTLR------REFLRLQ 359

Query: 421 ALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRRAAR 476
             + S  + LK Q Q  Q+ Q      +     Q Q + +  K  + +++   R  R  R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419

Query: 477 VLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP 536
            L   + Q R   +  ++ +  ++Q  + Q  + + L++  +  + Q Q+ ++    ++ 
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479

Query: 537 EQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLPLLS 593
           +QQQ+  Q+ +Q+ +Q    ++  +    +   PA     A E  E  R+N Q   PL  
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539

Query: 594 QDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPP--QAIGSVQALIEGLSRDLLRAP 651
                  P     +  IP        P +Q   ++ P     G  ++L +  +R+L   P
Sbjct: 540 SK-----PGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFP 594

Query: 652 NSNNSKPLGPLQT 664
            S++  P  P  T
Sbjct: 595 ASHDPDPAIPAPT 607



 Score =  282 bits (721), Expect = 2e-75
 Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)

Query: 986  EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
            EAP  P+ +   D S   +  + S   EE   G G    +R   G  +  D  ++     
Sbjct: 792  EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 848

Query: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
            H     +  +   G G   V RT EE   L L+ + N   T+ P + +P+    E  + +
Sbjct: 849  HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 906

Query: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
                 + S    S     AP   S    +     Q              G S D+   +A
Sbjct: 907  SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 953

Query: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
            ++      + +     ++ S VNVNP       + P I  Y+K F SEI C +LWGVNLL
Sbjct: 954  LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1013

Query: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
            +GT + L L+DRSG+  +  LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1014 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1073

Query: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
            IL+NDPE +++Q            +  + GC H+ V+++E   ++ IALKSS+ +YAWAP
Sbjct: 1074 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1125

Query: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
            K                                       P ++F         +  K F
Sbjct: 1126 K---------------------------------------PYHKF---------MAFKSF 1137

Query: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
              L H+P+ VDL +   +RLK+ + S+ G+H +D +S    D+ +P +    I P  II 
Sbjct: 1138 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1197

Query: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
            LP+  G+ M+L +  E + V    ++ K ++  W ++P+S+A+ C+ +  GWG+KAIE+R
Sbjct: 1198 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1257

Query: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            S+++  L+     +  ++L+FLC R DK+FF S      S+VYFMTL +
Sbjct: 1258 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1306



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)

Query: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L R+ LR    N +NS+ L   Q L           Q +Q R+ ++ +  L     +R+ 
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
            ++   +     ++ E    + + + +QRR ED+   + EEE RQ ++++E +    +E 
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459

Query: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
             S + + Q++    Y+ +       ++++ Q++   +P ++   +H            +
Sbjct: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511

Query: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
             A KP   R+   + R N         ++ SP+   +  S+ P   I Q
Sbjct: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score =  406 bits (1044), Expect = e-113
 Identities = 270/708 (38%), Positives = 376/708 (53%), Gaps = 81/708 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQV-RAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQ 534
                ++ Q+    R L++  Q    +QA     + + L++  +  + Q Q+ +Q+R   
Sbjct: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQL-KQERDYL 500

Query: 535 APEQQQRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQ 594
              Q QR  Q P   +E+       E    + +PA A+   E P  + V +Q      SQ
Sbjct: 501 VSLQHQRQEQRP---VEKKPLYHYKEGMSPSEKPAWAK---EIPHLVAVKSQGPALTASQ 554

Query: 595 DHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSN 654
             H               E  T+G               G  +AL     R  +   NS+
Sbjct: 555 SVH---------------EQPTKG-------------LSGFQEALNVTSHRVEMPRQNSD 586

Query: 655 NSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
            +    PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 587 PTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 634



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 934  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 991

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 992  LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1051

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1052 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1103

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1104 EIYAWAPK---------------------------------------PYHKF-------- 1116

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1117 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1175

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1176 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1235

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1236 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1291



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKE 750
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score =  406 bits (1044), Expect = e-113
 Identities = 270/708 (38%), Positives = 376/708 (53%), Gaps = 81/708 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381

Query: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441

Query: 476 RVLMPLQAQV-RAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQ 534
                ++ Q+    R L++  Q    +QA     + + L++  +  + Q Q+ +Q+R   
Sbjct: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQL-KQERDYL 500

Query: 535 APEQQQRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQ 594
              Q QR  Q P   +E+       E    + +PA A+   E P  + V +Q      SQ
Sbjct: 501 VSLQHQRQEQRP---VEKKPLYHYKEGMSPSEKPAWAK---EIPHLVAVKSQGPALTASQ 554

Query: 595 DHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSN 654
             H               E  T+G               G  +AL     R  +   NS+
Sbjct: 555 SVH---------------EQPTKG-------------LSGFQEALNVTSHRVEMPRQNSD 586

Query: 655 NSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
            +    PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 587 PTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 634



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 942  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 999

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1000 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1059

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1060 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1111

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1112 EIYAWAPK---------------------------------------PYHKF-------- 1124

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1125 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1183

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1184 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1243

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1244 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1299



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKE 750
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score =  405 bits (1041), Expect = e-112
 Identities = 245/598 (40%), Positives = 339/598 (56%), Gaps = 68/598 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           M  P   R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +
Sbjct: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61  ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+V+ T   +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 97  NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R   P +KS  WS+KF +F++ C IK +L 
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +L+ PF+RD   ER V   L  H   I + R+K+G     E+EE  + +Y+   
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327

Query: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420
               S                    HGE  +P  +     P    L+      R F+ LQ
Sbjct: 328 EEDDS--------------------HGEEGEPSSI--MNVPGESTLR------REFLRLQ 359

Query: 421 ALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRRAAR 476
             + S  + LK Q Q  Q+ Q      +     Q Q + +  K  + +++   R  R  R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419

Query: 477 VLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP 536
            L   + Q R   +  ++ +  ++Q  + Q  + + L++  +  + Q Q+ ++    ++ 
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479

Query: 537 EQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLPL 591
           +QQQ+  Q+ +Q+ +Q    ++  +    +   PA     A E  E  R+N Q   PL
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPL 537



 Score =  282 bits (721), Expect = 2e-75
 Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)

Query: 986  EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
            EAP  P+ +   D S   +  + S   EE   G G    +R   G  +  D  ++     
Sbjct: 783  EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 839

Query: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
            H     +  +   G G   V RT EE   L L+ + N   T+ P + +P+    E  + +
Sbjct: 840  HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 897

Query: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
                 + S    S     AP   S    +     Q              G S D+   +A
Sbjct: 898  SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 944

Query: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
            ++      + +     ++ S VNVNP       + P I  Y+K F SEI C +LWGVNLL
Sbjct: 945  LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1004

Query: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
            +GT + L L+DRSG+  +  LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1005 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1064

Query: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
            IL+NDPE +++Q            +  + GC H+ V+++E   ++ IALKSS+ +YAWAP
Sbjct: 1065 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1116

Query: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
            K                                       P ++F         +  K F
Sbjct: 1117 K---------------------------------------PYHKF---------MAFKSF 1128

Query: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
              L H+P+ VDL +   +RLK+ + S+ G+H +D +S    D+ +P +    I P  II 
Sbjct: 1129 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1188

Query: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
            LP+  G+ M+L +  E + V    ++ K ++  W ++P+S+A+ C+ +  GWG+KAIE+R
Sbjct: 1189 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1248

Query: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            S+++  L+     +  ++L+FLC R DK+FF S      S+VYFMTL +
Sbjct: 1249 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1297



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)

Query: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L R+ LR    N +NS+ L   Q L           Q +Q R+ ++ +  L     +R+ 
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
            ++   +     ++ E    + + + +QRR ED+   + EEE RQ ++++E +    +E 
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459

Query: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
             S + + Q++    Y+ +       ++++ Q++   +P ++   +H            +
Sbjct: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511

Query: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
             A KP   R+   + R N         ++ SP+   +  S+ P   I Q
Sbjct: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score =  405 bits (1041), Expect = e-112
 Identities = 245/598 (40%), Positives = 339/598 (56%), Gaps = 68/598 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           M  P   R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +
Sbjct: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61  ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+V+ T   +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 97  NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R   P +KS  WS+KF +F++ C IK +L 
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +L+ PF+RD   ER V   L  H   I + R+K+G     E+EE  + +Y+   
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327

Query: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420
               S                    HGE  +P  +     P    L+      R F+ LQ
Sbjct: 328 EEDDS--------------------HGEEGEPSSI--MNVPGESTLR------REFLRLQ 359

Query: 421 ALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRRAAR 476
             + S  + LK Q Q  Q+ Q      +     Q Q + +  K  + +++   R  R  R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419

Query: 477 VLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP 536
            L   + Q R   +  ++ +  ++Q  + Q  + + L++  +  + Q Q+ ++    ++ 
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479

Query: 537 EQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLPL 591
           +QQQ+  Q+ +Q+ +Q    ++  +    +   PA     A E  E  R+N Q   PL
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPL 537



 Score =  282 bits (721), Expect = 2e-75
 Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)

Query: 986  EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
            EAP  P+ +   D S   +  + S   EE   G G    +R   G  +  D  ++     
Sbjct: 812  EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 868

Query: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
            H     +  +   G G   V RT EE   L L+ + N   T+ P + +P+    E  + +
Sbjct: 869  HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 926

Query: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
                 + S    S     AP   S    +     Q              G S D+   +A
Sbjct: 927  SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 973

Query: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
            ++      + +     ++ S VNVNP       + P I  Y+K F SEI C +LWGVNLL
Sbjct: 974  LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1033

Query: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
            +GT + L L+DRSG+  +  LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1034 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1093

Query: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
            IL+NDPE +++Q            +  + GC H+ V+++E   ++ IALKSS+ +YAWAP
Sbjct: 1094 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1145

Query: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
            K                                       P ++F         +  K F
Sbjct: 1146 K---------------------------------------PYHKF---------MAFKSF 1157

Query: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
              L H+P+ VDL +   +RLK+ + S+ G+H +D +S    D+ +P +    I P  II 
Sbjct: 1158 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1217

Query: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
            LP+  G+ M+L +  E + V    ++ K ++  W ++P+S+A+ C+ +  GWG+KAIE+R
Sbjct: 1218 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1277

Query: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            S+++  L+     +  ++L+FLC R DK+FF S      S+VYFMTL +
Sbjct: 1278 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1326



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)

Query: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L R+ LR    N +NS+ L   Q L           Q +Q R+ ++ +  L     +R+ 
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
            ++   +     ++ E    + + + +QRR ED+   + EEE RQ ++++E +    +E 
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459

Query: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
             S + + Q++    Y+ +       ++++ Q++   +P ++   +H            +
Sbjct: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511

Query: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
             A KP   R+   + R N         ++ SP+   +  S+ P   I Q
Sbjct: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score =  405 bits (1041), Expect = e-112
 Identities = 245/598 (40%), Positives = 339/598 (56%), Gaps = 68/598 (11%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           M  P   R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +
Sbjct: 1   MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61  ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+V+ T   +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 97  NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R   P +KS  WS+KF +F++ C IK +L 
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +L+ PF+RD   ER V   L  H   I + R+K+G     E+EE  + +Y+   
Sbjct: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327

Query: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ 420
               S                    HGE  +P  +     P    L+      R F+ LQ
Sbjct: 328 EEDDS--------------------HGEEGEPSSI--MNVPGESTLR------REFLRLQ 359

Query: 421 ALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRRAAR 476
             + S  + LK Q Q  Q+ Q      +     Q Q + +  K  + +++   R  R  R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419

Query: 477 VLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP 536
            L   + Q R   +  ++ +  ++Q  + Q  + + L++  +  + Q Q+ ++    ++ 
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479

Query: 537 EQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLPL 591
           +QQQ+  Q+ +Q+ +Q    ++  +    +   PA     A E  E  R+N Q   PL
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPL 537



 Score =  282 bits (721), Expect = 2e-75
 Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)

Query: 986  EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
            EAP  P+ +   D S   +  + S   EE   G G    +R   G  +  D  ++     
Sbjct: 775  EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 831

Query: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
            H     +  +   G G   V RT EE   L L+ + N   T+ P + +P+    E  + +
Sbjct: 832  HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 889

Query: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
                 + S    S     AP   S    +     Q              G S D+   +A
Sbjct: 890  SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 936

Query: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
            ++      + +     ++ S VNVNP       + P I  Y+K F SEI C +LWGVNLL
Sbjct: 937  LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 996

Query: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
            +GT + L L+DRSG+  +  LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 997  VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1056

Query: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
            IL+NDPE +++Q            +  + GC H+ V+++E   ++ IALKSS+ +YAWAP
Sbjct: 1057 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1108

Query: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
            K                                       P ++F         +  K F
Sbjct: 1109 K---------------------------------------PYHKF---------MAFKSF 1120

Query: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
              L H+P+ VDL +   +RLK+ + S+ G+H +D +S    D+ +P +    I P  II 
Sbjct: 1121 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1180

Query: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
            LP+  G+ M+L +  E + V    ++ K ++  W ++P+S+A+ C+ +  GWG+KAIE+R
Sbjct: 1181 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1240

Query: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            S+++  L+     +  ++L+FLC R DK+FF S      S+VYFMTL +
Sbjct: 1241 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1289



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)

Query: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L R+ LR    N +NS+ L   Q L           Q +Q R+ ++ +  L     +R+ 
Sbjct: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
            ++   +     ++ E    + + + +QRR ED+   + EEE RQ ++++E +    +E 
Sbjct: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459

Query: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
             S + + Q++    Y+ +       ++++ Q++   +P ++   +H            +
Sbjct: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511

Query: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
             A KP   R+   + R N         ++ SP+   +  S+ P   I Q
Sbjct: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score =  405 bits (1040), Expect = e-112
 Identities = 240/586 (40%), Positives = 336/586 (57%), Gaps = 55/586 (9%)

Query: 14  DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
           DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +             
Sbjct: 14  DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60

Query: 74  KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
                      DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG   QLW+VME C 
Sbjct: 61  -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109

Query: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
           AGS+TD+V+ T   +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169

Query: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
           VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+WS GITAIEMAEG
Sbjct: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229

Query: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           APPLC++ P+ ALF+I R   P +KS  WS+KF +F+E C +KN++ RP++  +L+HPF+
Sbjct: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289

Query: 314 RDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRRFRG-PSCTHELLR 372
           RD  NER V   L  H+    KKR +K     +E   + +E+  V    G PS    ++ 
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKD-ETEYEYSGSEEEEEEVPEQEGEPS---SIVN 345

Query: 373 LPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKPLK 430
           +P  S  R   LR+      +   L  ++  Q Q L++ +   R     Q L    K ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKR-----QLLAERQKRIE 400

Query: 431 GQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAPRL 490
            Q +  +RL+   R       + +A+  +  + + +     RR   +    + +    R 
Sbjct: 401 QQKEQRRRLEEQQR------REREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA 454

Query: 491 LQVQSQVSKKQQ-AQTQTSEPQDLDQVPEEFQGQDQV--------PEQQRQGQAPEQQQR 541
            + + +V ++Q+  + Q  E Q   +V ++   Q+Q         P  Q   Q P  QQ 
Sbjct: 455 EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQE 514

Query: 542 HNQ----VPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRV 583
            ++     PE +     A    EV+++  +   +  EA+  ++ RV
Sbjct: 515 RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRV 560



 Score =  280 bits (717), Expect = 6e-75
 Identities = 155/424 (36%), Positives = 238/424 (56%), Gaps = 58/424 (13%)

Query: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
            SPS G+ +++   F+   +    +   ++  ++ S VNVNP    P    P I  Y+K F
Sbjct: 841  SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 898

Query: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
             SEI C +LWGVNLL+GT S L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG 
Sbjct: 899  NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 958

Query: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
            K++LRVY+L+WLRNKIL+NDPE +++Q            +  L GC H+ V+++E   ++
Sbjct: 959  KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 1010

Query: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
             IALKSS+ +YAWAPK                                       P ++F
Sbjct: 1011 VIALKSSVEVYAWAPK---------------------------------------PYHKF 1031

Query: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
                     +  K F  L HKP+ VDL +   +RLK+ + S  G+H +D +S  + D+ L
Sbjct: 1032 ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1082

Query: 1449 PKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFEC 1508
            P +    I P  IIILP+  G+ +++ +  E + V    ++ K ++  W ++P+S+A+  
Sbjct: 1083 PTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1142

Query: 1509 TQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFM 1568
            + +T GWG+KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+VYFM
Sbjct: 1143 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1202

Query: 1569 TLGK 1572
            TLG+
Sbjct: 1203 TLGR 1206



 Score = 34.7 bits (78), Expect = 0.75
 Identities = 59/233 (25%), Positives = 93/233 (39%), Gaps = 50/233 (21%)

Query: 643 LSRDLLRAPNSNN--SKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L RD LR    N   S+ L   Q L E           +Q RE++      RQ LA+R  
Sbjct: 352 LRRDFLRLQQENKERSEALRRQQLLQE-----------QQLREQEEYK---RQLLAERQK 397

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQ--RRQRRWEDIFNQHEEELRQVDKDKEDESSDNDE 758
               + +   R E+ +  + EARRQ  R QRR E    +  EEL +  K++E+     +E
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457

Query: 759 VFHSIQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQ----------DHAH-HVKFSSSV 807
                  + ++E  + YI   +++E ++R   V   Q          DH   H + S   
Sbjct: 458 -------KRRVEREQEYIR--RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQP 508

Query: 808 PQRSLLEQAQKP----------IDIRQRSSQNRQNWLAASESSSEEESPVTGR 850
           P     ++  KP           +   R+ +    +   + SS E +S  TGR
Sbjct: 509 PPPQ--QERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGR 559


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  402 bits (1034), Expect = e-111
 Identities = 241/591 (40%), Positives = 330/591 (55%), Gaps = 101/591 (17%)

Query: 14  DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
           DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+  +             
Sbjct: 14  DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60

Query: 74  KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
                      DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG   QLW+VME C 
Sbjct: 61  -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109

Query: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
           AGS+TD+V+ T   +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169

Query: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
           VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YDYRSD+WS GITAIEMAEG
Sbjct: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229

Query: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           APPLC++ P+ ALF+I R   P +KS  WS+KF +F+E C +KN++ RP++  +L+HPF+
Sbjct: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289

Query: 314 RDIKNERHVVESLTRHLTGIIKKRQKKG-----IPLIFEREEAIKEQYTVRRFRGPSCTH 368
           RD  NER V   L  H+    KKR +K           E EE + EQ             
Sbjct: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQ------------- 336

Query: 369 ELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKP 428
                             GEPS    +P                 R F+ LQ      + 
Sbjct: 337 -----------------EGEPSSIVNVPGEST-----------LRRDFLRLQ------QE 362

Query: 429 LKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAP 488
            K +++A +R Q      +  Q + K +     Q +I+     RR       L+ Q R  
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR------LEEQQRRE 416

Query: 489 RLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP--------EQQQ 540
           R  + Q +  ++++ Q +    ++L++  +E + + +  E++R+ +          E++Q
Sbjct: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476

Query: 541 RHNQVPEQELEQNQA-------PEQPEVQEQAAEPAQAETE----AEEPES 580
           RH +V +Q+L Q QA          P+  +Q   P Q  ++    A EP++
Sbjct: 477 RHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKA 527



 Score =  279 bits (714), Expect = 1e-74
 Identities = 158/432 (36%), Positives = 241/432 (55%), Gaps = 66/432 (15%)

Query: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
            SPS G+ +++   F+   +    +   ++  ++ S VNVNP    P    P I  Y+K F
Sbjct: 787  SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 844

Query: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
             SEI C +LWGVNLL+GT S L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG 
Sbjct: 845  NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 904

Query: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
            K++LRVY+L+WLRNKIL+NDPE +++Q            +  L GC H+ V+++E   ++
Sbjct: 905  KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 956

Query: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
             IALKSS+ +YAWAPK                                       P ++F
Sbjct: 957  VIALKSSVEVYAWAPK---------------------------------------PYHKF 977

Query: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
                     +  K F  L HKP+ VDL +   +RLK+ + S  G+H +D +S  + D+ L
Sbjct: 978  ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1028

Query: 1449 P----KNPLEI----IIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI 1500
            P    KNP  +    I P  IIILP+  G+ +++ +  E + V    ++ K ++  W ++
Sbjct: 1029 PTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEM 1088

Query: 1501 PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN 1560
            P+S+A+  + +T GWG+KAIE+RS+++  L+     +  ++L+FLC R DK+FF S    
Sbjct: 1089 PTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1148

Query: 1561 HHSRVYFMTLGK 1572
              S+VYFMTLG+
Sbjct: 1149 GSSQVYFMTLGR 1160



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 81/374 (21%), Positives = 130/374 (34%), Gaps = 55/374 (14%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L    LR       + L   Q  +E     R   + +Q RE++++    R+   +    K
Sbjct: 376 LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEK 435

Query: 703 R-FRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFH 761
           R        R E+ E    E  ++R +R  E I  Q EEE R ++  ++    +   + H
Sbjct: 436 RRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLH 495

Query: 762 SIQAE----------VQIEPLKPYISNPKK---IEVQERSPSVP---------------- 792
             +             Q E  KP    P+     E  +R+  VP                
Sbjct: 496 DHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSP 555

Query: 793 -----NNQDHAHHVKFSSSVPQRSLLEQAQKPID---IRQRSSQNRQNWLAASESSSEEE 844
                     A     +SS+  R L E+ +K +        S  +       S   S+  
Sbjct: 556 LQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSG 615

Query: 845 SPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFRNDW 904
           S    R   SS    +  Q+L   +  P+  K  ++  P+    E V   AL++  R   
Sbjct: 616 SGERFRVRSSSKSEGSPSQRLENAVKKPEDKK--EVFRPLKPAGE-VDLTALAKELR--- 669

Query: 905 LTPAPVIQPPEEDGDYVELYDASADTDGDDD-------DESNDTFEDTYDHANGNDDLDN 957
                 ++PP +  DY    + S  TD +DD       DES    EDT   A  + +L N
Sbjct: 670 --AVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDT--RAASSLNLSN 725

Query: 958 QVDQANDVCKDHDD 971
              ++      HDD
Sbjct: 726 GETESVKTMIVHDD 739



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 18/120 (15%)

Query: 643 LSRDLLRAPNSNN--SKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
           L RD LR    N   S+ L   Q L E           +Q RE++      RQ LA+R  
Sbjct: 352 LRRDFLRLQQENKERSEALRRQQLLQE-----------QQLREQEEYK---RQLLAERQK 397

Query: 701 PKRFRAKSSWRPEKLELSDLEARRQ--RRQRRWEDIFNQHEEELRQVDKDKEDESSDNDE 758
               + +   R E+ +  + EARRQ  R QRR E    +  EEL +  K++E+     +E
Sbjct: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457



 Score = 31.6 bits (70), Expect = 6.4
 Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 13/130 (10%)

Query: 485 VRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ-RQGQAPEQQQRHN 543
           +R  +LLQ Q    +++  +   +E Q   ++ ++ + + ++ EQQ R+ +A  QQ+R  
Sbjct: 370 LRRQQLLQEQQLREQEEYKRQLLAERQK--RIEQQKEQRRRLEEQQRREREARRQQEREQ 427

Query: 544 QVPEQE----LEQNQAPEQPEVQEQAAEPAQAETEAEEP------ESLRVNAQVFLPLLS 593
           +  EQE    LE+ +   + E + + AE  +   E E+       E  + + +V    L 
Sbjct: 428 RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLL 487

Query: 594 QDHHVLLPLH 603
           Q+  +LL  H
Sbjct: 488 QEQAMLLHDH 497


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  400 bits (1028), Expect = e-111
 Identities = 250/704 (35%), Positives = 366/704 (51%), Gaps = 102/704 (14%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPL 419
             G PS    +L LP  S  R                                 R F+ L
Sbjct: 334 DSGEPS---SILNLPGESTLR---------------------------------RDFLRL 357

Query: 420 QALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLM 479
           Q  +      K +++A +R Q        L+ Q +       Q+  +   R+        
Sbjct: 358 QLAN------KERSEALRRQQ--------LEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403

Query: 480 PLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQ 539
            L+ Q R  + L+ Q +  +++  + Q    ++  +   E + + +  E+QRQ +  ++Q
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463

Query: 540 QRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVL 599
            +  +     L+  +  ++P  ++      +  + +E+P   +                 
Sbjct: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK----------------- 506

Query: 600 LPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-RDLLRAPNSNNSKP 658
                +   L+ V+ Q      +Q+   +P + +   Q  +   S R  +   NS+ +  
Sbjct: 507 -----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE 561

Query: 659 LGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
             PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 562 NPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 905  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 962

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 963  LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1022

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1023 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1074

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1075 EIYAWAPK---------------------------------------PYHKF-------- 1087

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1088 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1146

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1147 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1206

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1207 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1262



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 36/168 (21%), Positives = 71/168 (42%), Gaps = 16/168 (9%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457

Query: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQR 810
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++
Sbjct: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEK 501


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  400 bits (1028), Expect = e-111
 Identities = 250/704 (35%), Positives = 366/704 (51%), Gaps = 102/704 (14%)

Query: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59

Query: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96

Query: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156

Query: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216

Query: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276

Query: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333

Query: 361 FRG-PSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPL 419
             G PS    +L LP  S  R                                 R F+ L
Sbjct: 334 DSGEPS---SILNLPGESTLR---------------------------------RDFLRL 357

Query: 420 QALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLM 479
           Q  +      K +++A +R Q        L+ Q +       Q+  +   R+        
Sbjct: 358 QLAN------KERSEALRRQQ--------LEQQQRENEEHKRQLLAERQKRIEEQKEQRR 403

Query: 480 PLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQ 539
            L+ Q R  + L+ Q +  +++  + Q    ++  +   E + + +  E+QRQ +  ++Q
Sbjct: 404 RLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQ 463

Query: 540 QRHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVL 599
            +  +     L+  +  ++P  ++      +  + +E+P   +                 
Sbjct: 464 LKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK----------------- 506

Query: 600 LPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-RDLLRAPNSNNSKP 658
                +   L+ V+ Q      +Q+   +P + +   Q  +   S R  +   NS+ +  
Sbjct: 507 -----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE 561

Query: 659 LGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
             PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 562 NPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 913  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 970

Query: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 971  LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1030

Query: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1031 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1082

Query: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
             +YAWAPK                                       P ++F        
Sbjct: 1083 EIYAWAPK---------------------------------------PYHKF-------- 1095

Query: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1096 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1154

Query: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1155 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1214

Query: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1215 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1270



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 36/168 (21%), Positives = 71/168 (42%), Gaps = 16/168 (9%)

Query: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401

Query: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457

Query: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQR 810
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++
Sbjct: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEK 501


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  255 bits (652), Expect = 2e-67
 Identities = 132/320 (41%), Positives = 196/320 (61%), Gaps = 28/320 (8%)

Query: 17  HLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQ 76
           + PDP+  + + +TIG GTYG+++  L++K G   AVK+++    P+ +I          
Sbjct: 13  NFPDPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILD----PIHDI---------- 58

Query: 77  KSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGS 136
                     +E++  E N+L+  S H N+V FYG +FK        +LW+V+ELC+ GS
Sbjct: 59  ----------DEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNG-DKLWLVLELCSGGS 107

Query: 137 VTDVVR--MTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLV 194
           VTD+V+  +   + + E  IAYI  E L GL HLH ++ IHRD+KG N+LLT    VKLV
Sbjct: 108 VTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLV 167

Query: 195 DFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGA 254
           DFGVSAQ++ T  RRN+ +GTP+WMAPEVI C++    +YD R D WS+GITAIE+ +G 
Sbjct: 168 DFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGD 227

Query: 255 PPLCNLQPLEALFVILRESAPTVKSSG-WSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           PPL +L P+ ALF I R   P ++    WS +F++F+ KC  K++  RPT + +LQH F+
Sbjct: 228 PPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287

Query: 314 RDIKNERHVVESLTRHLTGI 333
             I+ +  +++       GI
Sbjct: 288 TQIEGKDVMLQKQLTEFIGI 307


>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
          Length = 1314

 Score =  251 bits (641), Expect = 4e-66
 Identities = 139/339 (41%), Positives = 203/339 (59%), Gaps = 32/339 (9%)

Query: 15  LGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNK 74
           L  LPDPT  + + +TIG GTYG++Y   +++ G+  AVK+++                 
Sbjct: 17  LESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDP---------------- 60

Query: 75  YQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAA 134
                    SD +E++  E N+L+    H N+V FYG F+K +      QLW+V+ELC  
Sbjct: 61  --------VSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYK-ADHCVGGQLWLVLELCNG 111

Query: 135 GSVTDVVR--MTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVK 192
           GSVT++V+  +   Q L E  I+YI    L GL HLH +R+IHRD+KG N+LLT    VK
Sbjct: 112 GSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVK 171

Query: 193 LVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAE 252
           LVDFGVSAQ++ T  RRN+ +GTP+WMAPEVI C++    SYD R DVWS+GITAIE+ +
Sbjct: 172 LVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGD 231

Query: 253 GAPPLCNLQPLEALFVILRESAPT-VKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHP 311
           G PPL ++ P++ LF I R   PT +    W  +F++F+ +C IK+F  RP+  ++L HP
Sbjct: 232 GDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHP 291

Query: 312 FVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE 350
           F++ +  +   V  L + L  +++  QK   P+   R E
Sbjct: 292 FIKGVHGK---VLFLQKQLAKVLQD-QKHQNPVAKTRHE 326


>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
          Length = 1341

 Score =  251 bits (641), Expect = 4e-66
 Identities = 139/339 (41%), Positives = 203/339 (59%), Gaps = 32/339 (9%)

Query: 15  LGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNK 74
           L  LPDPT  + + +TIG GTYG++Y   +++ G+  AVK+++                 
Sbjct: 17  LESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDP---------------- 60

Query: 75  YQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAA 134
                    SD +E++  E N+L+    H N+V FYG F+K +      QLW+V+ELC  
Sbjct: 61  --------VSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYK-ADHCVGGQLWLVLELCNG 111

Query: 135 GSVTDVVR--MTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVK 192
           GSVT++V+  +   Q L E  I+YI    L GL HLH +R+IHRD+KG N+LLT    VK
Sbjct: 112 GSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVK 171

Query: 193 LVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAE 252
           LVDFGVSAQ++ T  RRN+ +GTP+WMAPEVI C++    SYD R DVWS+GITAIE+ +
Sbjct: 172 LVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGD 231

Query: 253 GAPPLCNLQPLEALFVILRESAPT-VKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHP 311
           G PPL ++ P++ LF I R   PT +    W  +F++F+ +C IK+F  RP+  ++L HP
Sbjct: 232 GDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHP 291

Query: 312 FVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREE 350
           F++ +  +   V  L + L  +++  QK   P+   R E
Sbjct: 292 FIKGVHGK---VLFLQKQLAKVLQD-QKHQNPVAKTRHE 326


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score =  206 bits (525), Expect = 1e-52
 Identities = 112/295 (37%), Positives = 167/295 (56%), Gaps = 32/295 (10%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           +P   + +   +G G +G++Y   +++T    A KV++ +                    
Sbjct: 29  NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS------------------- 69

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                +E ED   E+++L     H NIV    AF+        + LW+++E CA G+V D
Sbjct: 70  ----EEELEDYMVEIDILASCD-HPNIVKLLDAFY------YENNLWILIEFCAGGAV-D 117

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
            V +   + L E  I  +C++ L  L +LH +++IHRD+K  N+L T + ++KL DFGVS
Sbjct: 118 AVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS 177

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           A+ +RT  RR+SFIGTPYWMAPEV+ C+    R YDY++DVWS+GIT IEMAE  PP   
Sbjct: 178 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE 237

Query: 260 LQPLEALFVILRESAPTV-KSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           L P+  L  I +   PT+ + S WS  F +F++KC  KN   R T++ +LQHPFV
Sbjct: 238 LNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  206 bits (524), Expect = 1e-52
 Identities = 119/320 (37%), Positives = 183/320 (57%), Gaps = 40/320 (12%)

Query: 21  PTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVG 80
           P  +F + + +G G+YG +Y  +H++TG   A+K +                        
Sbjct: 26  PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--------------------- 64

Query: 81  WRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDV 140
              SD +E ++ E++++++     ++V +YG++FK +       LW+VME C AGSV+D+
Sbjct: 65  ---SDLQEIIK-EISIMQQCD-SPHVVKYYGSYFKNT------DLWIVMEYCGAGSVSDI 113

Query: 141 VRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSA 200
           +R+  N++L ED IA I +  L+GL +LH  R IHRDIK  N+LL      KL DFGV+ 
Sbjct: 114 IRLR-NKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAG 172

Query: 201 QVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNL 260
           Q++ T  +RN+ IGTP+WMAPEVI         Y+  +D+WS+GITAIEMAEG PP  ++
Sbjct: 173 QLTDTMAKRNTVIGTPFWMAPEVIQ-----EIGYNCVADIWSLGITAIEMAEGKPPYADI 227

Query: 261 QPLEALFVILRESAPTV-KSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNE 319
            P+ A+F+I     PT  K   WS  F +F+++C +K+   R T+  +LQHPFVR  K  
Sbjct: 228 HPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGV 287

Query: 320 RHVVESLTRHLTGIIKKRQK 339
             ++  L      +  KRQ+
Sbjct: 288 -SILRDLINEAMDVKLKRQE 306


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  206 bits (524), Expect = 1e-52
 Identities = 122/314 (38%), Positives = 176/314 (56%), Gaps = 42/314 (13%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           +P   F L + IG GTYG +Y   +  TG   A+KV+                       
Sbjct: 11  NPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEP------------------- 51

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
           G  ++  ++++     ++ K   H NIV+++G++ +      R +LW+ ME C  GS+ D
Sbjct: 52  GEDFAVVQQEI-----IMMKDCKHPNIVAYFGSYLR------RDKLWICMEFCGGGSLQD 100

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           +  +T    L E  IAY+ RE LQGL +LH+   +HRDIKG N+LLT N  VKL DFGVS
Sbjct: 101 IYHVTG--PLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVS 158

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           AQ++ T  +R SFIGTPYWMAPEV   +   +  Y+   D+W+VGITAIE+AE  PP+ +
Sbjct: 159 AQITATIAKRKSFIGTPYWMAPEVAAVER--KGGYNQLCDLWAVGITAIELAELQPPMFD 216

Query: 260 LQPLEALFVILRES--APTVKSS-GWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDI 316
           L P+ ALF++ + +   P +K    WS  FH+F++    KN   RPT+  +LQHPFV   
Sbjct: 217 LHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV--- 273

Query: 317 KNERHVVESLTRHL 330
              +H+  SL   L
Sbjct: 274 --TQHLTRSLAIEL 285


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  202 bits (514), Expect = 2e-51
 Identities = 117/336 (34%), Positives = 192/336 (57%), Gaps = 39/336 (11%)

Query: 21  PTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSVG 80
           P  +F + + +G G+YG ++  +H+++G   A+K +                        
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--------------------- 61

Query: 81  WRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTDV 140
              SD +E ++ E++++++      +V +YG++FK +       LW+VME C AGSV+D+
Sbjct: 62  ---SDLQEIIK-EISIMQQCD-SPYVVKYYGSYFKNT------DLWIVMEYCGAGSVSDI 110

Query: 141 VRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSA 200
           +R+  N++L ED IA I +  L+GL +LH  R IHRDIK  N+LL      KL DFGV+ 
Sbjct: 111 IRLR-NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAG 169

Query: 201 QVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCNL 260
           Q++ T  +RN+ IGTP+WMAPEVI         Y+  +D+WS+GIT+IEMAEG PP  ++
Sbjct: 170 QLTDTMAKRNTVIGTPFWMAPEVIQ-----EIGYNCVADIWSLGITSIEMAEGKPPYADI 224

Query: 261 QPLEALFVILRESAPTV-KSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDIKNE 319
            P+ A+F+I     PT  K   WS  F +F++KC +KN   R T+  +LQHPF+++ K  
Sbjct: 225 HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPV 284

Query: 320 RHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQ 355
             + + +T  +    K+ +++   L  E E + +++
Sbjct: 285 SILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDE 320


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  202 bits (514), Expect = 2e-51
 Identities = 153/438 (34%), Positives = 220/438 (50%), Gaps = 64/438 (14%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           DP   + L + +G GTYG ++    + +G   A+K++                       
Sbjct: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP------------------- 52

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                D+   L+ E+ L+ K   H NIV+++G++  L       +LW+ ME C AGS+ D
Sbjct: 53  ----DDDVSTLQKEI-LILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQD 101

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           + ++T   SL E  I+Y+CRE+LQGLA+LH+ + IHRDIKG N+L+    EV+L DFG+S
Sbjct: 102 IYQVTG--SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGIS 159

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           AQ+  T  RR SFIGTPYWMAPEV       +  Y+   D+WS+GITAIE+AE  PPL +
Sbjct: 160 AQIGATLARRLSFIGTPYWMAPEV--AAVALKGGYNELCDIWSLGITAIELAELQPPLFD 217

Query: 260 LQPLEALFVILRE--SAPTVKSSG-WSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDI 316
           + PL  LF++ +     P +K  G WS  FHNF++    K+   RP++  ML H  V   
Sbjct: 218 VHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQP 277

Query: 317 KNERHVVESLTRHLTGIIKKRQKKGIPLI--FEREEAIKEQYTVRRFRGPSCTH--ELLR 372
              R ++  L   L     K   KG P I   E EE        RR R    TH    L 
Sbjct: 278 GLNRGLILDLLDKL-----KNPGKG-PSIGDIEDEEPELPPAIPRRIRS---THRSSSLG 328

Query: 373 LPTSSRCR---PLRVLHGEPSQP-----RWLPDREEPQVQALQQLQGAA-----RVFMPL 419
           +P +  CR     R L G  ++P     R  P R+       +QL  ++      V +P 
Sbjct: 329 IPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPT 388

Query: 420 QALDSAPK-PLKGQAQAP 436
            A D+ P  P K + ++P
Sbjct: 389 PAEDTPPPLPPKPKFRSP 406


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score =  202 bits (514), Expect = 2e-51
 Identities = 153/438 (34%), Positives = 220/438 (50%), Gaps = 64/438 (14%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           DP   + L + +G GTYG ++    + +G   A+K++                       
Sbjct: 12  DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP------------------- 52

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                D+   L+ E+ L+ K   H NIV+++G++  L       +LW+ ME C AGS+ D
Sbjct: 53  ----DDDVSTLQKEI-LILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQD 101

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           + ++T   SL E  I+Y+CRE+LQGLA+LH+ + IHRDIKG N+L+    EV+L DFG+S
Sbjct: 102 IYQVTG--SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGIS 159

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           AQ+  T  RR SFIGTPYWMAPEV       +  Y+   D+WS+GITAIE+AE  PPL +
Sbjct: 160 AQIGATLARRLSFIGTPYWMAPEV--AAVALKGGYNELCDIWSLGITAIELAELQPPLFD 217

Query: 260 LQPLEALFVILRE--SAPTVKSSG-WSRKFHNFMEKCTIKNFLFRPTSANMLQHPFVRDI 316
           + PL  LF++ +     P +K  G WS  FHNF++    K+   RP++  ML H  V   
Sbjct: 218 VHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQP 277

Query: 317 KNERHVVESLTRHLTGIIKKRQKKGIPLI--FEREEAIKEQYTVRRFRGPSCTH--ELLR 372
              R ++  L   L     K   KG P I   E EE        RR R    TH    L 
Sbjct: 278 GLNRGLILDLLDKL-----KNPGKG-PSIGDIEDEEPELPPAIPRRIRS---THRSSSLG 328

Query: 373 LPTSSRCR---PLRVLHGEPSQP-----RWLPDREEPQVQALQQLQGAA-----RVFMPL 419
           +P +  CR     R L G  ++P     R  P R+       +QL  ++      V +P 
Sbjct: 329 IPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPT 388

Query: 420 QALDSAPK-PLKGQAQAP 436
            A D+ P  P K + ++P
Sbjct: 389 PAEDTPPPLPPKPKFRSP 406


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  201 bits (510), Expect = 6e-51
 Identities = 114/311 (36%), Positives = 180/311 (57%), Gaps = 39/311 (12%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           DP  +F+    IG G++G +Y G+   T    A+K+++  +                   
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEA------------------ 56

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                DE ED++ E+ +L +      I  ++G++ K +      +LW++ME    GS  D
Sbjct: 57  ----EDEIEDIQQEITVLSQCD-SPYITRYFGSYLKST------KLWIIMEYLGGGSALD 105

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           +++      L+E +IA I REIL+GL +LH+ R IHRDIK  NVLL+   +VKL DFGV+
Sbjct: 106 LLKPGP---LEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVA 162

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
            Q++ T  +RN+F+GTP+WMAPEVI      + +YD+++D+WS+GITAIE+A+G PP  +
Sbjct: 163 GQLTDTQIKRNTFVGTPFWMAPEVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSD 217

Query: 260 LQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV-RDIKN 318
           L P+  LF+I + S PT++    S+ F  F+E C  K+  FRPT+  +L+H F+ R  K 
Sbjct: 218 LHPMRVLFLIPKNSPPTLEGQ-HSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 276

Query: 319 ERHVVESLTRH 329
              + E + R+
Sbjct: 277 TSFLTELIDRY 287


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score =  199 bits (505), Expect = 2e-50
 Identities = 111/318 (34%), Positives = 176/318 (55%), Gaps = 32/318 (10%)

Query: 8   RDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIG 67
           + RE   +    DP  ++ +   +G G +G++Y   +++TGA  A KV+  +        
Sbjct: 19  KSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKS------- 71

Query: 68  RRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWM 127
                            +E ED   E+ +L     H  IV   GA++         +LW+
Sbjct: 72  ----------------EEELEDYIVEIEILATCD-HPYIVKLLGAYY------HDGKLWI 108

Query: 128 VMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTH 187
           ++E C  G+V D + +  ++ L E  I  +CR++L+ L  LH+ R+IHRD+K  NVL+T 
Sbjct: 109 MIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL 167

Query: 188 NAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITA 247
             +++L DFGVSA+  +T  +R+SFIGTPYWMAPEV+ C+      YDY++D+WS+GIT 
Sbjct: 168 EGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITL 227

Query: 248 IEMAEGAPPLCNLQPLEALFVILRESAPTVKS-SGWSRKFHNFMEKCTIKNFLFRPTSAN 306
           IEMA+  PP   L P+  L  I +   PT+ + S WS +F +F++    KN   RP++A 
Sbjct: 228 IEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQ 287

Query: 307 MLQHPFVRDIKNERHVVE 324
           +L+HPFV  I + + + E
Sbjct: 288 LLEHPFVSSITSNKALRE 305


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  199 bits (505), Expect = 2e-50
 Identities = 113/297 (38%), Positives = 170/297 (57%), Gaps = 37/297 (12%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           +P   + L + +G GTYG +Y   +  TG   AVK++                       
Sbjct: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------------------- 55

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                D+   ++ E+ ++++   H NIV+++G++        R +LW+ ME C  GS+ D
Sbjct: 56  ----GDDFSLIQQEIFMVKECK-HCNIVAYFGSYLS------REKLWICMEYCGGGSLQD 104

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           +  +T    L E  IAY+CRE LQGLA+LH    +HRDIKG N+LLT + +VKL DFGV+
Sbjct: 105 IYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           A+++ T  +R SFIGTPYWMAPEV   +++    Y+   D+W+VGITAIE+ E  PP+ +
Sbjct: 163 AKITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFD 220

Query: 260 LQPLEALFVILRES--APTVK-SSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           L P+ ALF++ + +   P +K  + WS  FHNF++    KN   RPT+  +L H FV
Sbjct: 221 LHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  199 bits (505), Expect = 2e-50
 Identities = 113/297 (38%), Positives = 170/297 (57%), Gaps = 37/297 (12%)

Query: 20  DPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQKSV 79
           +P   + L + +G GTYG +Y   +  TG   AVK++                       
Sbjct: 15  NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEP------------------- 55

Query: 80  GWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSVTD 139
                D+   ++ E+ ++++   H NIV+++G++        R +LW+ ME C  GS+ D
Sbjct: 56  ----GDDFSLIQQEIFMVKECK-HCNIVAYFGSYLS------REKLWICMEYCGGGSLQD 104

Query: 140 VVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVS 199
           +  +T    L E  IAY+CRE LQGLA+LH    +HRDIKG N+LLT + +VKL DFGV+
Sbjct: 105 IYHVTG--PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVA 162

Query: 200 AQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPLCN 259
           A+++ T  +R SFIGTPYWMAPEV   +++    Y+   D+W+VGITAIE+ E  PP+ +
Sbjct: 163 AKITATIAKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFD 220

Query: 260 LQPLEALFVILRES--APTVK-SSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
           L P+ ALF++ + +   P +K  + WS  FHNF++    KN   RPT+  +L H FV
Sbjct: 221 LHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  198 bits (504), Expect = 3e-50
 Identities = 113/298 (37%), Positives = 164/298 (55%), Gaps = 37/298 (12%)

Query: 18  LPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVNKYQK 77
           L DP   F L + +G GTYG +Y      T    AVK++                     
Sbjct: 9   LQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDP----------------- 51

Query: 78  SVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCAAGSV 137
                  D+   L+ E+ +LR+   H N+V++ G++ +        +LW+ ME C  GS+
Sbjct: 52  ------GDDISSLQQEITILRECR-HPNVVAYIGSYLR------NDRLWICMEFCGGGSL 98

Query: 138 TDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFG 197
            ++   T    L+E  IAY+CRE L+GL HLH+   IHRDIKG N+LLT   +VKL DFG
Sbjct: 99  QEIYHATG--PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFG 156

Query: 198 VSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEGAPPL 257
           VS +++ +  +R SFIGTPYWMAPEV   +   +  Y+   DVW++GITAIE+ E  PPL
Sbjct: 157 VSGELTASVAKRRSFIGTPYWMAPEVAAVER--KGGYNELCDVWALGITAIELGELQPPL 214

Query: 258 CNLQPLEALFVILRESAPTVK---SSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPF 312
            +L P+ AL ++ + S    K    + W++ FH+F++    KN   RPT+  +LQHPF
Sbjct: 215 FHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,186,641
Number of Sequences: 37866
Number of extensions: 3171776
Number of successful extensions: 21426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 748
Number of HSP's successfully gapped in prelim test: 642
Number of HSP's that attempted gapping in prelim test: 12648
Number of HSP's gapped (non-prelim): 5119
length of query: 1582
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1466
effective length of database: 13,855,062
effective search space: 20311520892
effective search space used: 20311520892
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.