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Search of human proteins with 10863935
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10863935 reticulon 1 isoform A [Homo sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10863935 reticulon 1 isoform A [Homo sapiens] 1540 0.0
gi|45827778 reticulon 1 isoform B [Homo sapiens] 701 0.0
gi|45827776 reticulon 1 isoform C [Homo sapiens] 364 e-100
gi|24431933 reticulon 4 isoform B [Homo sapiens] 287 3e-77
gi|47519490 reticulon 4 isoform D [Homo sapiens] 286 7e-77
gi|47519562 reticulon 4 isoform E [Homo sapiens] 271 2e-72
gi|5902016 reticulon 4 isoform C [Homo sapiens] 271 2e-72
gi|24431935 reticulon 4 isoform A [Homo sapiens] 271 2e-72
gi|5174655 reticulon 3 isoform a [Homo sapiens] 238 2e-62
gi|41393604 reticulon 3 isoform c [Homo sapiens] 235 1e-61
gi|41393608 reticulon 3 isoform b [Homo sapiens] 233 4e-61
gi|46255005 reticulon 2 isoform B [Homo sapiens] 211 3e-54
gi|41393606 reticulon 3 isoform d [Homo sapiens] 204 2e-52
gi|5032055 reticulon 2 isoform A [Homo sapiens] 197 3e-50
gi|46255007 reticulon 2 isoform C [Homo sapiens] 197 3e-50
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 5e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 57 5e-08
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 57 5e-08
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 57 5e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 57 5e-08
gi|163965366 nascent polypeptide-associated complex alpha subuni... 55 2e-07
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 55 2e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 54 7e-07
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 52 2e-06
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 52 3e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 52 3e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 52 3e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 52 3e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 52 3e-06
gi|150170670 piccolo isoform 2 [Homo sapiens] 51 4e-06
>gi|10863935 reticulon 1 isoform A [Homo sapiens]
Length = 776
Score = 1540 bits (3986), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAAS 60
MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAAS
Sbjct: 1 MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAAS 60
Query: 61 REAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDS 120
REAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDS
Sbjct: 61 REAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDS 120
Query: 121 TYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNK 180
TYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNK
Sbjct: 121 TYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNK 180
Query: 181 ILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPD 240
ILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPD
Sbjct: 181 ILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPD 240
Query: 241 KPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKT 300
KPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKT
Sbjct: 241 KPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKT 300
Query: 301 PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAI 360
PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAI
Sbjct: 301 PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAI 360
Query: 361 KEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDP 420
KEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDP
Sbjct: 361 KEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDP 420
Query: 421 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 480
MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES
Sbjct: 421 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 480
Query: 481 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 540
PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD
Sbjct: 481 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 540
Query: 541 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 600
GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ
Sbjct: 541 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 600
Query: 601 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 660
TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY
Sbjct: 601 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 660
Query: 661 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 720
LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN
Sbjct: 661 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 720
Query: 721 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
Sbjct: 721 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
>gi|45827778 reticulon 1 isoform B [Homo sapiens]
Length = 356
Score = 701 bits (1808), Expect = 0.0
Identities = 356/356 (100%), Positives = 356/356 (100%)
Query: 421 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 480
MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES
Sbjct: 1 MAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES 60
Query: 481 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 540
PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD
Sbjct: 61 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 120
Query: 541 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 600
GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ
Sbjct: 121 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQ 180
Query: 601 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 660
TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY
Sbjct: 181 TGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAY 240
Query: 661 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 720
LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN
Sbjct: 241 LELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFN 300
Query: 721 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
Sbjct: 301 GLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
>gi|45827776 reticulon 1 isoform C [Homo sapiens]
Length = 208
Score = 364 bits (935), Expect = e-100
Identities = 189/191 (98%), Positives = 190/191 (99%)
Query: 586 KQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 645
K +AIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL
Sbjct: 18 KSQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 77
Query: 646 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 705
QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF
Sbjct: 78 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 137
Query: 706 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 765
AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ
Sbjct: 138 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 197
Query: 766 AKIPGAKRHAE 776
AKIPGAKRHAE
Sbjct: 198 AKIPGAKRHAE 208
>gi|24431933 reticulon 4 isoform B [Homo sapiens]
Length = 373
Score = 287 bits (734), Expect = 3e-77
Identities = 171/361 (47%), Positives = 218/361 (60%), Gaps = 28/361 (7%)
Query: 441 PPSPASPSIQYSILRE----EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD 496
PP P P+ +Y +RE E E E + E E + E P + P+ P+A
Sbjct: 16 PPRP-QPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPV-PTAPA 73
Query: 497 AIREETGVRAEERAPSRRG---LAEPGSFLDYPSTEPQPGPELPPGDGAL---------- 543
A + P+ RG A P + PS +P P P L
Sbjct: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKL 133
Query: 544 --EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKA------IDLLYW 595
+ E P P P S S Q+ P P P APP K++ +DLLYW
Sbjct: 134 PEDDEPPARPPPPPPASVSPQAEPVWTPPAP-APAAPPSTPAAPKRRGSSGSVVVDLLYW 192
Query: 596 RDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGH 655
RDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGH
Sbjct: 193 RDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGH 252
Query: 656 PFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYV 715
PF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYV
Sbjct: 253 PFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYV 312
Query: 716 GALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHA 775
GALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR A
Sbjct: 313 GALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKA 372
Query: 776 E 776
E
Sbjct: 373 E 373
Score = 33.1 bits (74), Expect = 1.0
Identities = 38/145 (26%), Positives = 58/145 (40%), Gaps = 24/145 (16%)
Query: 193 AYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEG--VREPDKPAPVEGKII 250
A+KY + PE+ + +E+ E ED+DL+ + + KP P AP G +
Sbjct: 22 AFKYQFVREPEDEEEEEEEEEEDEDEDLE---ELEVLERKPAAGLSAAPVPTAPAAGAPL 78
Query: 251 KDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKP 310
D + +D R P P E +PS + + T P
Sbjct: 79 MD----------FGNDFVPPAPRGPLPAAPP--VAPERQPSWDPSPVSSTVP------AP 120
Query: 311 SPDTVPTVTVSE-PEDDSPGSITPP 334
SP + V+ S+ PEDD P + PP
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPP 145
>gi|47519490 reticulon 4 isoform D [Homo sapiens]
Length = 392
Score = 286 bits (731), Expect = 7e-77
Identities = 182/429 (42%), Positives = 237/429 (55%), Gaps = 72/429 (16%)
Query: 380 LADRPEVKARSGPPT---------IPSPLDHEASSAESGDSE------IELVSEDPMAAE 424
L P V + PP + P D E E + E +E++ P A
Sbjct: 4 LDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGL 63
Query: 425 DALP--------SGYVSFGHVGGPP----PSPASPSIQYSILREEREAELDSELIIESCD 472
A P + + FG+ PP P PA+P + ER+ D + +
Sbjct: 64 SAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVA-----PERQPSWDPSPVSSTVP 118
Query: 473 ASS---ASEESPKR--EQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPS 527
A S A+ SP + E D PP +P S AEP
Sbjct: 119 APSPLSAAAVSPSKLPEDDEPPARPPP-------------PPPASVSPQAEP------VW 159
Query: 528 TEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQ 587
T P P P PP TP P++ S +++ A P A P++
Sbjct: 160 TPPAPAPAAPPS-------TPAAPKRRGSSGSVDETLFAL-------PAASEPVI--RSS 203
Query: 588 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 647
+DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA
Sbjct: 204 AVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQA 263
Query: 648 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 707
+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAV
Sbjct: 264 IQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV 323
Query: 708 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 767
LMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAK
Sbjct: 324 LMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAK 383
Query: 768 IPGAKRHAE 776
IPG KR AE
Sbjct: 384 IPGLKRKAE 392
Score = 34.7 bits (78), Expect = 0.35
Identities = 45/179 (25%), Positives = 73/179 (40%), Gaps = 13/179 (7%)
Query: 193 AYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEG--VREPDKPAPVEGKII 250
A+KY + PE+ + +E+ E ED+DL+ + KP P AP G +
Sbjct: 22 AFKYQFVREPEDEEEEEEEEEEDEDEDLEELEV---LERKPAAGLSAAPVPTAPAAGAPL 78
Query: 251 KDHLLEESTFAPYIDDLSEEQRRAPQIT-----TPVKITLTEIEP-SVETTTQEKTPEKQ 304
D + AP L AP+ +PV T+ P S + K PE
Sbjct: 79 MDFGNDFVPPAPR-GPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDD 137
Query: 305 DICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEA 363
+ +P P +V+ +P + P + + P+A + +G S S DE + A+ A
Sbjct: 138 EPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG-SSGSVDETLFALPAA 195
>gi|47519562 reticulon 4 isoform E [Homo sapiens]
Length = 986
Score = 271 bits (692), Expect = 2e-72
Identities = 222/654 (33%), Positives = 323/654 (49%), Gaps = 81/654 (12%)
Query: 141 EELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDIT 200
E TP P LPD+ + L S+ P+ V + + PL+ A + Y
Sbjct: 396 ESEATPSPVLPDI--VMEAPLNSA------VPSAGASVIQPSSSPLE---ASSVNY---- 440
Query: 201 RPEEVKHQEQHHPELEDKDLDFKNKDTDISIKP-EGVREPDKPAPVEGKIIKDHLLEEST 259
E +KH+ ++ P E+ +S+K G++E K E + I L E T
Sbjct: 441 --ESIKHEPENPPPYEEA--------MSVSLKKVSGIKEEIK----EPENINAALQE--T 484
Query: 260 FAPYID---DLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVP 316
APYI DL +E + + + + S ++ P+ ++ SPD+ P
Sbjct: 485 EAPYISIACDLIKETKLSAEPAPDFS------DYSEMAKVEQPVPDHSELVEDSSPDSEP 538
Query: 317 TVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISE------DELITAIKEAKGLSYET 370
S DDS + T ES + S E ++A+ G Y
Sbjct: 539 VDLFS---DDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE 595
Query: 371 A-----ENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAED 425
+ +N + L D EV S IP ++ +++ S D +S++ E
Sbjct: 596 SFKLSLDNTKDT-LLPD--EVSTLSKKEKIPLQMEELSTAVYSNDDLF--ISKEAQIRET 650
Query: 426 ALPSGYVSFGHVGGPPPSPASPSIQYSIL-REEREAELDSELIIESCDASSASEESPKRE 484
S + P +S + +S L RE + E+ + I + + S +
Sbjct: 651 ETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELP 710
Query: 485 QDSP--PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGA 542
D ++P + I A S+ L P + +T+ + + P
Sbjct: 711 HDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPD--VSALATQAEIESIVKPKVLV 768
Query: 543 LEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTG 602
E E + P + ++SP+A L+K +DLLYWRDIK+TG
Sbjct: 769 KEAEKKL----PSDTEKEDRSPSAIFSAE------------LSKTSVVDLLYWRDIKKTG 812
Query: 603 IVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLE 662
+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGHPF+AYLE
Sbjct: 813 VVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLE 872
Query: 663 LEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGL 722
E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYVGALFNGL
Sbjct: 873 SEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGL 932
Query: 723 TLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
TLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR AE
Sbjct: 933 TLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 986
Score = 34.3 bits (77), Expect = 0.45
Identities = 80/371 (21%), Positives = 131/371 (35%), Gaps = 84/371 (22%)
Query: 217 DKDLDFKNKDTDISIKPEGVRE---------PDKPAPVEGKIIKDHLLEESTFAPYIDDL 267
+KD + N DT PEG+++ P PA E + P + D
Sbjct: 229 EKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATES--------IATNIFPLLGDP 280
Query: 268 SEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPS-PDTVPTVTVSEPEDD 326
+ E + T KI + + E T KT + + S D V T +++ ++
Sbjct: 281 TSENK-----TDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEE 335
Query: 327 SPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEV 386
++ G P + + ++E +T K ++YET + L EV
Sbjct: 336 VVANM---PEGLTPDLVQEACESELNE---VTGTK----IAYETKMD------LVQTSEV 379
Query: 387 KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
S P E S A ++V E P+ A+PS S V P SP
Sbjct: 380 MQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPL--NSAVPSAGAS---VIQPSSSP-- 432
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD-AIREETGVR 505
+ASS + ES K E ++PP A+ ++++ +G++
Sbjct: 433 ------------------------LEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIK 468
Query: 506 AEERAPSRRGLAEPGSFLDYPS----------TEPQPGPELPPGDGALEPETPMLPRKPE 555
E + P A + Y S +P P+ + E P +P E
Sbjct: 469 EEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQP-VPDHSE 527
Query: 556 --EDSSSNQSP 564
EDSS + P
Sbjct: 528 LVEDSSPDSEP 538
>gi|5902016 reticulon 4 isoform C [Homo sapiens]
Length = 199
Score = 271 bits (692), Expect = 2e-72
Identities = 130/191 (68%), Positives = 161/191 (84%)
Query: 586 KQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVL 645
K K +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+
Sbjct: 9 KDKVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVI 68
Query: 646 QAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKF 705
QA+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKF
Sbjct: 69 QAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKF 128
Query: 706 AVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQ 765
AVLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQ
Sbjct: 129 AVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQ 188
Query: 766 AKIPGAKRHAE 776
AKIPG KR AE
Sbjct: 189 AKIPGLKRKAE 199
>gi|24431935 reticulon 4 isoform A [Homo sapiens]
Length = 1192
Score = 271 bits (692), Expect = 2e-72
Identities = 222/654 (33%), Positives = 323/654 (49%), Gaps = 81/654 (12%)
Query: 141 EELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDIT 200
E TP P LPD+ + L S+ P+ V + + PL+ A + Y
Sbjct: 602 ESEATPSPVLPDI--VMEAPLNSA------VPSAGASVIQPSSSPLE---ASSVNY---- 646
Query: 201 RPEEVKHQEQHHPELEDKDLDFKNKDTDISIKP-EGVREPDKPAPVEGKIIKDHLLEEST 259
E +KH+ ++ P E+ +S+K G++E K E + I L E T
Sbjct: 647 --ESIKHEPENPPPYEEA--------MSVSLKKVSGIKEEIK----EPENINAALQE--T 690
Query: 260 FAPYID---DLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVP 316
APYI DL +E + + + + S ++ P+ ++ SPD+ P
Sbjct: 691 EAPYISIACDLIKETKLSAEPAPDFS------DYSEMAKVEQPVPDHSELVEDSSPDSEP 744
Query: 317 TVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISE------DELITAIKEAKGLSYET 370
S DDS + T ES + S E ++A+ G Y
Sbjct: 745 VDLFS---DDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE 801
Query: 371 A-----ENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAED 425
+ +N + L D EV S IP ++ +++ S D +S++ E
Sbjct: 802 SFKLSLDNTKDT-LLPD--EVSTLSKKEKIPLQMEELSTAVYSNDDLF--ISKEAQIRET 856
Query: 426 ALPSGYVSFGHVGGPPPSPASPSIQYSIL-REEREAELDSELIIESCDASSASEESPKRE 484
S + P +S + +S L RE + E+ + I + + S +
Sbjct: 857 ETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELP 916
Query: 485 QDSP--PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGA 542
D ++P + I A S+ L P + +T+ + + P
Sbjct: 917 HDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPD--VSALATQAEIESIVKPKVLV 974
Query: 543 LEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTG 602
E E + P + ++SP+A L+K +DLLYWRDIK+TG
Sbjct: 975 KEAEKKL----PSDTEKEDRSPSAIFSAE------------LSKTSVVDLLYWRDIKKTG 1018
Query: 603 IVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLE 662
+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGHPF+AYLE
Sbjct: 1019 VVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLE 1078
Query: 663 LEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGL 722
E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYVGALFNGL
Sbjct: 1079 SEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGL 1138
Query: 723 TLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 776
TLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR AE
Sbjct: 1139 TLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 1192
Score = 41.2 bits (95), Expect = 0.004
Identities = 69/328 (21%), Positives = 127/328 (38%), Gaps = 32/328 (9%)
Query: 193 AYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEG--VREPDKPAPVEGKII 250
A+KY + PE+ + +E+ E ED+DL+ + + KP P AP G +
Sbjct: 22 AFKYQFVREPEDEEEEEEEEEEDEDEDLE---ELEVLERKPAAGLSAAPVPTAPAAGAPL 78
Query: 251 KDHLLEESTFAPY----IDDLSEEQRRAPQITTPVKITLTEIEP-SVETTTQEKTPEKQD 305
D + AP +R+ +PV T+ P S + K PE +
Sbjct: 79 MDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDE 138
Query: 306 ICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKG 365
+P P +V+ +P + P + + P+A + +G ++ L ++
Sbjct: 139 PPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
Query: 366 LSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAED 425
+ +AEN L ++P +G PS L A+S L S P++A
Sbjct: 199 VIRSSAENM----DLKEQPGNTISAGQEDFPSVLLETAAS---------LPSLSPLSAAS 245
Query: 426 ALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQ 485
Y+ G++ P ++Q ++ +E ++ ++ D + SE
Sbjct: 246 FKEHEYL--GNLS--TVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMG 301
Query: 486 DSPPMKPSALDAI-----REETGVRAEE 508
S + P A A+ REE V+ ++
Sbjct: 302 SSFSVSPKAESAVIVANPREEIIVKNKD 329
Score = 34.3 bits (77), Expect = 0.45
Identities = 80/371 (21%), Positives = 131/371 (35%), Gaps = 84/371 (22%)
Query: 217 DKDLDFKNKDTDISIKPEGVRE---------PDKPAPVEGKIIKDHLLEESTFAPYIDDL 267
+KD + N DT PEG+++ P PA E + P + D
Sbjct: 435 EKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATES--------IATNIFPLLGDP 486
Query: 268 SEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPS-PDTVPTVTVSEPEDD 326
+ E + T KI + + E T KT + + S D V T +++ ++
Sbjct: 487 TSENK-----TDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEE 541
Query: 327 SPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEV 386
++ G P + + ++E +T K ++YET + L EV
Sbjct: 542 VVANM---PEGLTPDLVQEACESELNE---VTGTK----IAYETKMD------LVQTSEV 585
Query: 387 KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
S P E S A ++V E P+ A+PS S V P SP
Sbjct: 586 MQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPL--NSAVPSAGAS---VIQPSSSP-- 638
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD-AIREETGVR 505
+ASS + ES K E ++PP A+ ++++ +G++
Sbjct: 639 ------------------------LEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIK 674
Query: 506 AEERAPSRRGLAEPGSFLDYPS----------TEPQPGPELPPGDGALEPETPMLPRKPE 555
E + P A + Y S +P P+ + E P +P E
Sbjct: 675 EEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQP-VPDHSE 733
Query: 556 --EDSSSNQSP 564
EDSS + P
Sbjct: 734 LVEDSSPDSEP 744
Score = 32.0 bits (71), Expect = 2.2
Identities = 42/158 (26%), Positives = 56/158 (35%), Gaps = 22/158 (13%)
Query: 441 PPSPASPSIQYSILRE----EREAELDSELIIESCDASSASEESPKREQDSPPMKPSALD 496
PP P P+ +Y +RE E E E + E E + E P + P+ P+A
Sbjct: 16 PPRP-QPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPV-PTAPA 73
Query: 497 AIREETGVRAEERAPSRRG---LAEPGSFLDYPSTEPQPGPELPPGDGAL---------- 543
A + P+ RG A P + PS +P P P L
Sbjct: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKL 133
Query: 544 --EPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPP 579
+ E P P P S S Q+ P P P APP
Sbjct: 134 PEDDEPPARPPPPPPASVSPQAEPVWTPPAP-APAAPP 170
>gi|5174655 reticulon 3 isoform a [Homo sapiens]
Length = 236
Score = 238 bits (606), Expect = 2e-62
Identities = 123/223 (55%), Positives = 164/223 (73%), Gaps = 6/223 (2%)
Query: 558 SSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAI---DLLYWRDIKQTGIVFGSFLLLLFS 614
SS P+A G G PGA P L + + DL++WRD+K+TG VFG+ L++L S
Sbjct: 16 SSFGAEPSAPGGGG--SPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLS 73
Query: 615 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK 674
L FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPFKAYL+++ITLS E
Sbjct: 74 LAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHN 133
Query: 675 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT 734
Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA+FNG+TLL++A + +F+
Sbjct: 134 YMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFS 193
Query: 735 LPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG-AKRHAE 776
+P+VY K++ QID Y+G+ R ++V KIQAK+PG AK+ AE
Sbjct: 194 VPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 236
>gi|41393604 reticulon 3 isoform c [Homo sapiens]
Length = 255
Score = 235 bits (600), Expect = 1e-61
Identities = 120/240 (50%), Positives = 166/240 (69%), Gaps = 10/240 (4%)
Query: 538 PGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRD 597
PG G P L K S ++ +++ P+ + + DL++WRD
Sbjct: 25 PGGGGSPGACPALGTKSCSSSCADSFVSSSSSQ---------PVSLFSTSQVHDLIFWRD 75
Query: 598 IKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPF 657
+K+TG VFG+ L++L SL FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPF
Sbjct: 76 VKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPF 135
Query: 658 KAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGA 717
KAYL+++ITLS E Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA
Sbjct: 136 KAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGA 195
Query: 718 LFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG-AKRHAE 776
+FNG+TLL++A + +F++P+VY K++ QID Y+G+ R ++V KIQAK+PG AK+ AE
Sbjct: 196 VFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 255
>gi|41393608 reticulon 3 isoform b [Homo sapiens]
Length = 1013
Score = 233 bits (595), Expect = 4e-61
Identities = 112/187 (59%), Positives = 150/187 (80%), Gaps = 1/187 (0%)
Query: 591 DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQK 650
DL++WRD+K+TG VFG+ L++L SL FSV+SVV+YL LA LS TISFRIYKSV+QAVQK
Sbjct: 827 DLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQK 886
Query: 651 TDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMW 710
++EGHPFKAYL+++ITLS E Y + ++N LK + RLFLV+DLVDSLK AV MW
Sbjct: 887 SEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMW 946
Query: 711 LLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPG 770
L+TYVGA+FNG+TLL++A + +F++P+VY K++ QID Y+G+ R ++V KIQAK+PG
Sbjct: 947 LMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPG 1006
Query: 771 -AKRHAE 776
AK+ AE
Sbjct: 1007 IAKKKAE 1013
>gi|46255005 reticulon 2 isoform B [Homo sapiens]
Length = 472
Score = 211 bits (536), Expect = 3e-54
Identities = 126/314 (40%), Positives = 185/314 (58%), Gaps = 29/314 (9%)
Query: 470 SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 529
S + SS S +P +D P +P+ L ETG EE R L PS+
Sbjct: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
Query: 530 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP--------- 580
P+L PG G + TP P + + +S + P + GP P
Sbjct: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDST 259
Query: 581 --LLFLNKQKAI--DLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATI 636
L F + + + DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TI
Sbjct: 260 DQLEFTVEPRLLVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTI 319
Query: 637 SFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLV 696
S R+Y+ VLQAV + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV
Sbjct: 320 SLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLV 379
Query: 697 QDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTH 756
+DLVDSLK A+L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV
Sbjct: 380 EDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQ 439
Query: 757 INAVVAKIQAKIPG 770
++ + AKI+AKIPG
Sbjct: 440 LSHIKAKIRAKIPG 453
>gi|41393606 reticulon 3 isoform d [Homo sapiens]
Length = 241
Score = 204 bits (520), Expect = 2e-52
Identities = 105/189 (55%), Positives = 140/189 (74%), Gaps = 5/189 (2%)
Query: 558 SSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAI---DLLYWRDIKQTGIVFGSFLLLLFS 614
SS P+A G G PGA P L + + DL++WRD+K+TG VFG+ L++L S
Sbjct: 16 SSFGAEPSAPGGGG--SPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLS 73
Query: 615 LTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQK 674
L FSV+SVV+YL LA LS TISFRIYKSV+QAVQK++EGHPFKAYL+++ITLS E
Sbjct: 74 LAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHN 133
Query: 675 YTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFT 734
Y + ++N LK + RLFLV+DLVDSLK AV MWL+TYVGA+FNG+TLL++A + +F+
Sbjct: 134 YMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFS 193
Query: 735 LPVVYVKHQ 743
+P+VY K++
Sbjct: 194 VPIVYEKYK 202
>gi|5032055 reticulon 2 isoform A [Homo sapiens]
Length = 545
Score = 197 bits (501), Expect = 3e-50
Identities = 94/183 (51%), Positives = 137/183 (74%)
Query: 588 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 647
K DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TIS R+Y+ VLQA
Sbjct: 344 KVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQA 403
Query: 648 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 707
V + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV+DLVDSLK A+
Sbjct: 404 VHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLAL 463
Query: 708 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 767
L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV ++ + AKI+AK
Sbjct: 464 LFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAK 523
Query: 768 IPG 770
IPG
Sbjct: 524 IPG 526
Score = 31.2 bits (69), Expect = 3.8
Identities = 30/106 (28%), Positives = 43/106 (40%), Gaps = 16/106 (15%)
Query: 470 SCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTE 529
S + SS S +P +D P +P+ L ETG EE R L PS+
Sbjct: 156 SGEDSSTSSSTPL--EDEEPQEPNRL-----ETGEAGEELDLRLR--------LAQPSSP 200
Query: 530 PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGP 575
P+L PG G + TP P + + +S + P + GP
Sbjct: 201 EVLTPQLSPGSGTPQAGTPS-PSRSRDSNSGPEEPLLEEEEKQWGP 245
>gi|46255007 reticulon 2 isoform C [Homo sapiens]
Length = 205
Score = 197 bits (501), Expect = 3e-50
Identities = 94/183 (51%), Positives = 137/183 (74%)
Query: 588 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 647
K DLLYW+D + +G+VF ++ L L FS+VSV A+LAL L TIS R+Y+ VLQA
Sbjct: 4 KVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQA 63
Query: 648 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 707
V + D +PF+AYL++++TL++EQ ++ + + V S +LR FLV+DLVDSLK A+
Sbjct: 64 VHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLAL 123
Query: 708 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 767
L ++LT+VGA+FNGLTLL++ V+ +FT+P++Y +HQAQIDQY+GLV ++ + AKI+AK
Sbjct: 124 LFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAK 183
Query: 768 IPG 770
IPG
Sbjct: 184 IPG 186
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 63.9 bits (154), Expect = 5e-10
Identities = 95/417 (22%), Positives = 157/417 (37%), Gaps = 42/417 (10%)
Query: 162 FSSDSGIEMTPAESTEVNKILADP----LDQMKAEAYKYIDITRPEEVKHQEQHHPELED 217
FS G+ P+ ST + K+ ++ +++ + E + T +V + E E
Sbjct: 420 FSLPEGLPKIPSVSTHI-KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEA 478
Query: 218 KDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQI 277
K+ + K ++ + EG E K P E E+ +P + EE + +
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP----EKEAKSP----VKEEAKSPAEA 530
Query: 278 TTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPED-DSPGSITPPSS 336
+P K ++ + K+PEK K + P E E+ SP + P
Sbjct: 531 KSPEK-------EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEK 583
Query: 337 GTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRP-EVKARSGPPTI 395
P+ E++ E A K + AE PV + A P EVK+ P
Sbjct: 584 AKSPAKEEAKSPAEAKSPE--KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS---PEKA 638
Query: 396 PSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPA-SPSIQYSIL 454
SP EA S E S + ++ P A+ + + S P + A SP S +
Sbjct: 639 KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 455 REEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRR 514
+EE ++ ++ S EE+ E+ P+K A + ++ V+ E ++P +
Sbjct: 699 KEEAKSPEKAK--------SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 515 GLAEPGSFLDYPSTEPQ-PGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGP 570
E LD S E + P E PE P K E +SP K P
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV-----KSPEKAKSP 802
Score = 54.3 bits (129), Expect = 4e-07
Identities = 89/408 (21%), Positives = 156/408 (38%), Gaps = 37/408 (9%)
Query: 177 EVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGV 236
E K A+ K EA ++ PE+ K + + + K+ + + + P V
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP---EAKSPEKEEAKSPAEV 578
Query: 237 REPDK---PAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVE 293
+ P+K PA E K + E +P + EE + + +PVK + V+
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSP----VKEEAKSPAEAKSPVKEE-AKSPAEVK 633
Query: 294 TTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISE 353
+ + K+P K++ SP+ + E + + P A+S K
Sbjct: 634 SPEKAKSPTKEEA---KSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 354 DELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSG-------PPTIPSPLDHEASSA 406
E + + + S E A++P V + A PE KA+S P SP+ EA S
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSP--VKEEAKSPE-KAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Query: 407 ESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSEL 466
E S + + D + E P+ + P SP ++EE ++ ++
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP------VKEEVKSPEKAKS 801
Query: 467 IIESCDASSASEESPKREQDSPPMKPSALD---AIREETGVRAEERAPSRRGLAE--PGS 521
++ DA + +E PK+E+ P+K ++E EE+AP+ E
Sbjct: 802 PLKE-DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK 860
Query: 522 FLDYPSTE-PQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATK 568
+ P E P+P E +P+ + K EE + P K
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK 908
Score = 37.7 bits (86), Expect = 0.041
Identities = 75/344 (21%), Positives = 122/344 (35%), Gaps = 54/344 (15%)
Query: 243 APVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPE 302
A +EG ++ L E F +D LSE + + +TE ++ T E
Sbjct: 276 AQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELE-- 333
Query: 303 KQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQG-----KGSISEDELI 357
LK + D++ SE ED I + AE + + E + +
Sbjct: 334 ----ALKSTKDSLERQR-SELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDL 388
Query: 358 TAIKEAKGLSYETAENPRPVGQLADRPEVKARSGP---------PTIPSPLDHEASSAES 408
+K A L E A +L + E + GP P IPS H +E
Sbjct: 389 LNVKMA--LDIEIA----AYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEE 442
Query: 409 GDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELII 468
+E ++ + E+ V + + +E +E E E
Sbjct: 443 KIKVVEKSEKETVIVEEQTEETQV-------------TEEVTEEEEKEAKEEEGKEEEGG 489
Query: 469 ESCDASSASEE--SPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYP 526
E +A EE SP E+ + P K A ++EE AE ++P + P + P
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEK-EAKSPVKEEAKSPAEAKSPEKEEAKSPAE-VKSP 547
Query: 527 STEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGP 570
P E E ++P + PE++ + +SPA K P
Sbjct: 548 EKAKSPAKE--------EAKSPPEAKSPEKEEA--KSPAEVKSP 581
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/444 (18%), Positives = 156/444 (35%), Gaps = 54/444 (12%)
Query: 145 TPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEE 204
TP P + D G GL + D + +T+ NK+ P IT +
Sbjct: 79 TPKPPVVDEAG---SGLDNGDFKVTTPDTSTTQHNKVSTSP------------KITTAKP 123
Query: 205 VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYI 264
+ + P + + + +++ + +K +GK E++T A
Sbjct: 124 INPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK-------EKTTSAKET 176
Query: 265 DDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEK---TPEKQDICLKPSPDTVPTVTVS 321
+ ++ + + P L + P ETTT+ TP++ P+P T +
Sbjct: 177 QSI---EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE------PTPTTPKEPAST 227
Query: 322 EPEDDSPGSI-TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQL 380
P++ +P +I + P++ EP+ ++ + ++ T KE + T + P P
Sbjct: 228 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP---APTTPKEPAPTTTK 284
Query: 381 ADRPEV-KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGG 439
P K+ P P+P + + + ++P P+
Sbjct: 285 EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 344
Query: 440 PP-PSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAI 498
P P+P +P +E E ++ E SP ++ P +
Sbjct: 345 PKEPAPTAPKKPAPTTPKEPAPTTPKEPA-----PTTTKEPSPTTPKEPAPTTTKSAPTT 399
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPE--TPMLPRKPEE 556
+E + AP+ EP P+T +P P P P+ P P++P
Sbjct: 400 TKEPAPTTTKSAPTTP--KEPS-----PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 452
Query: 557 DSSSNQSPAATKGPGPLGPGAPPP 580
+ +P TK P P P P P
Sbjct: 453 TTPKEPAPTTTKKPAPTTPKEPAP 476
Score = 55.1 bits (131), Expect = 2e-07
Identities = 120/554 (21%), Positives = 173/554 (31%), Gaps = 72/554 (12%)
Query: 34 TPKG--ATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDH 91
TPK T P P +E AS + P +P +++A T +
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPAS----TTPKEPTPTTIKSAPTTPKEPAPTTTK 253
Query: 92 TFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLP 151
+ TT K+ T+ P+E + T KE T +P P P+ P
Sbjct: 254 SAPTTPKE---PAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTP 306
Query: 152 DVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQH 211
P + + + E TP E +P T P+E
Sbjct: 307 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP------------TTPKEPAPTAPK 354
Query: 212 HPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQ 271
P + K P +PAP K +E AP +
Sbjct: 355 KP-------------APTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTT 399
Query: 272 RRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSI 331
+ P TT T EPS TTT+E P +P+P T + P++ +P +
Sbjct: 400 TKEPAPTTTKSAPTTPKEPS-PTTTKEPAPTTPK---EPAPTTPKKPAPTTPKEPAPTTP 455
Query: 332 TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSG 391
P+ T A + K TA K L+ T E P PE A
Sbjct: 456 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT-----TPEKPA--- 507
Query: 392 PPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQY 451
PT P L + + E P AA P P+P +P
Sbjct: 508 -PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK-----------EPAPTTPKEPA 555
Query: 452 SILREEREAELDSELI--IESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEER 509
+E E A + +E P K A +E T ++
Sbjct: 556 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 615
Query: 510 APSR-RGLAEPGSFLDYPSTEPQPGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAA 566
AP+ +G A P+T +P P P G L+ P P+KP + +P
Sbjct: 616 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTT 672
Query: 567 TKGPGPLGPGAPPP 580
TKGP P P
Sbjct: 673 TKGPTSTTSDKPAP 686
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/309 (20%), Positives = 114/309 (36%), Gaps = 37/309 (11%)
Query: 278 TTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITP---- 333
TTP K+T T E TT ++ P + +P+ T EP +P + P
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 544
Query: 334 ---PSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS 390
P++ EP+ + + E TA KG + T + P P P+ A
Sbjct: 545 EPAPTTPKEPAPTTPKEPAPTTPKE--TAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-- 600
Query: 391 GPPTIPSP----LDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
P T P D A + G + P ++ P+ P+P +
Sbjct: 601 -PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 659
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRA 506
P ++ EL + + ++++ + +P +++ P P +E
Sbjct: 660 P-------KKPAPKEL-APTTTKGPTSTTSDKPAPTTPKETAPTTP------KEPAPTTP 705
Query: 507 EERAPSRRGLAEP-GSFLDYPSTEPQP-----GPELPPGDGALEPETPMLPRKPEEDS-S 559
++ AP+ P S + P+T +P P+ + + EP L P+E
Sbjct: 706 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 765
Query: 560 SNQSPAATK 568
+ ++PAATK
Sbjct: 766 TTKTPAATK 774
Score = 33.1 bits (74), Expect = 1.0
Identities = 50/225 (22%), Positives = 80/225 (35%), Gaps = 22/225 (9%)
Query: 129 KENGHVTISE-SPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLD 187
KE T E +P P P+ P+ P + S+ T E T ++K +
Sbjct: 690 KETAPTTPKEPAPTTPKKPAPTTPETPPPTT-----SEVSTPTTTKEPTTIHKSPDESTP 744
Query: 188 QMKAEAYKYIDITRPEE-----VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKP 242
++ AE P+E K PE+ D K + D+ PE K
Sbjct: 745 ELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD-KTTERDLRTTPETTTAAPKM 803
Query: 243 APVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITL---TEIEPSVETTTQEK 299
E++T + ++ Q TTP KIT T + P V TT +K
Sbjct: 804 TKETATTT-----EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV--TTTKK 856
Query: 300 TPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAE 344
T +I KP P + + +P P + +P++ +
Sbjct: 857 TITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 901
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/444 (18%), Positives = 156/444 (35%), Gaps = 54/444 (12%)
Query: 145 TPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEE 204
TP P + D G GL + D + +T+ NK+ P IT +
Sbjct: 120 TPKPPVVDEAG---SGLDNGDFKVTTPDTSTTQHNKVSTSP------------KITTAKP 164
Query: 205 VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYI 264
+ + P + + + +++ + +K +GK E++T A
Sbjct: 165 INPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK-------EKTTSAKET 217
Query: 265 DDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEK---TPEKQDICLKPSPDTVPTVTVS 321
+ ++ + + P L + P ETTT+ TP++ P+P T +
Sbjct: 218 QSI---EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE------PTPTTPKEPAST 268
Query: 322 EPEDDSPGSI-TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQL 380
P++ +P +I + P++ EP+ ++ + ++ T KE + T + P P
Sbjct: 269 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP---APTTPKEPAPTTTK 325
Query: 381 ADRPEV-KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGG 439
P K+ P P+P + + + ++P P+
Sbjct: 326 EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 385
Query: 440 PP-PSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAI 498
P P+P +P +E E ++ E SP ++ P +
Sbjct: 386 PKEPAPTAPKKPAPTTPKEPAPTTPKEPA-----PTTTKEPSPTTPKEPAPTTTKSAPTT 440
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPE--TPMLPRKPEE 556
+E + AP+ EP P+T +P P P P+ P P++P
Sbjct: 441 TKEPAPTTTKSAPTTP--KEPS-----PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 493
Query: 557 DSSSNQSPAATKGPGPLGPGAPPP 580
+ +P TK P P P P P
Sbjct: 494 TTPKEPAPTTTKKPAPTTPKEPAP 517
Score = 55.1 bits (131), Expect = 2e-07
Identities = 120/554 (21%), Positives = 173/554 (31%), Gaps = 72/554 (12%)
Query: 34 TPKG--ATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDH 91
TPK T P P +E AS + P +P +++A T +
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPAS----TTPKEPTPTTIKSAPTTPKEPAPTTTK 294
Query: 92 TFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLP 151
+ TT K+ T+ P+E + T KE T +P P P+ P
Sbjct: 295 SAPTTPKE---PAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTP 347
Query: 152 DVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQH 211
P + + + E TP E +P T P+E
Sbjct: 348 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP------------TTPKEPAPTAPK 395
Query: 212 HPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQ 271
P + K P +PAP K +E AP +
Sbjct: 396 KP-------------APTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTT 440
Query: 272 RRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSI 331
+ P TT T EPS TTT+E P +P+P T + P++ +P +
Sbjct: 441 TKEPAPTTTKSAPTTPKEPS-PTTTKEPAPTTPK---EPAPTTPKKPAPTTPKEPAPTTP 496
Query: 332 TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSG 391
P+ T A + K TA K L+ T E P PE A
Sbjct: 497 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT-----TPEKPA--- 548
Query: 392 PPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQY 451
PT P L + + E P AA P P+P +P
Sbjct: 549 -PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK-----------EPAPTTPKEPA 596
Query: 452 SILREEREAELDSELI--IESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEER 509
+E E A + +E P K A +E T ++
Sbjct: 597 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 656
Query: 510 APSR-RGLAEPGSFLDYPSTEPQPGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAA 566
AP+ +G A P+T +P P P G L+ P P+KP + +P
Sbjct: 657 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTT 713
Query: 567 TKGPGPLGPGAPPP 580
TKGP P P
Sbjct: 714 TKGPTSTTSDKPAP 727
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/309 (20%), Positives = 114/309 (36%), Gaps = 37/309 (11%)
Query: 278 TTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITP---- 333
TTP K+T T E TT ++ P + +P+ T EP +P + P
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 585
Query: 334 ---PSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS 390
P++ EP+ + + E TA KG + T + P P P+ A
Sbjct: 586 EPAPTTPKEPAPTTPKEPAPTTPKE--TAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-- 641
Query: 391 GPPTIPSP----LDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
P T P D A + G + P ++ P+ P+P +
Sbjct: 642 -PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 700
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRA 506
P ++ EL + + ++++ + +P +++ P P +E
Sbjct: 701 P-------KKPAPKEL-APTTTKGPTSTTSDKPAPTTPKETAPTTP------KEPAPTTP 746
Query: 507 EERAPSRRGLAEP-GSFLDYPSTEPQP-----GPELPPGDGALEPETPMLPRKPEEDS-S 559
++ AP+ P S + P+T +P P+ + + EP L P+E
Sbjct: 747 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 806
Query: 560 SNQSPAATK 568
+ ++PAATK
Sbjct: 807 TTKTPAATK 815
Score = 33.1 bits (74), Expect = 1.0
Identities = 50/225 (22%), Positives = 80/225 (35%), Gaps = 22/225 (9%)
Query: 129 KENGHVTISE-SPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLD 187
KE T E +P P P+ P+ P + S+ T E T ++K +
Sbjct: 731 KETAPTTPKEPAPTTPKKPAPTTPETPPPTT-----SEVSTPTTTKEPTTIHKSPDESTP 785
Query: 188 QMKAEAYKYIDITRPEE-----VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKP 242
++ AE P+E K PE+ D K + D+ PE K
Sbjct: 786 ELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD-KTTERDLRTTPETTTAAPKM 844
Query: 243 APVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITL---TEIEPSVETTTQEK 299
E++T + ++ Q TTP KIT T + P V TT +K
Sbjct: 845 TKETATTT-----EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV--TTTKK 897
Query: 300 TPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAE 344
T +I KP P + + +P P + +P++ +
Sbjct: 898 TITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 942
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/444 (18%), Positives = 156/444 (35%), Gaps = 54/444 (12%)
Query: 145 TPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEE 204
TP P + D G GL + D + +T+ NK+ P IT +
Sbjct: 172 TPKPPVVDEAG---SGLDNGDFKVTTPDTSTTQHNKVSTSP------------KITTAKP 216
Query: 205 VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYI 264
+ + P + + + +++ + +K +GK E++T A
Sbjct: 217 INPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK-------EKTTSAKET 269
Query: 265 DDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEK---TPEKQDICLKPSPDTVPTVTVS 321
+ ++ + + P L + P ETTT+ TP++ P+P T +
Sbjct: 270 QSI---EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE------PTPTTPKEPAST 320
Query: 322 EPEDDSPGSI-TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQL 380
P++ +P +I + P++ EP+ ++ + ++ T KE + T + P P
Sbjct: 321 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP---APTTPKEPAPTTTK 377
Query: 381 ADRPEV-KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGG 439
P K+ P P+P + + + ++P P+
Sbjct: 378 EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 437
Query: 440 PP-PSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAI 498
P P+P +P +E E ++ E SP ++ P +
Sbjct: 438 PKEPAPTAPKKPAPTTPKEPAPTTPKEPA-----PTTTKEPSPTTPKEPAPTTTKSAPTT 492
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPE--TPMLPRKPEE 556
+E + AP+ EP P+T +P P P P+ P P++P
Sbjct: 493 TKEPAPTTTKSAPTTP--KEPS-----PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 545
Query: 557 DSSSNQSPAATKGPGPLGPGAPPP 580
+ +P TK P P P P P
Sbjct: 546 TTPKEPAPTTTKKPAPTTPKEPAP 569
Score = 55.1 bits (131), Expect = 2e-07
Identities = 120/554 (21%), Positives = 173/554 (31%), Gaps = 72/554 (12%)
Query: 34 TPKG--ATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDH 91
TPK T P P +E AS + P +P +++A T +
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPAS----TTPKEPTPTTIKSAPTTPKEPAPTTTK 346
Query: 92 TFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLP 151
+ TT K+ T+ P+E + T KE T +P P P+ P
Sbjct: 347 SAPTTPKE---PAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTP 399
Query: 152 DVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQH 211
P + + + E TP E +P T P+E
Sbjct: 400 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP------------TTPKEPAPTAPK 447
Query: 212 HPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQ 271
P + K P +PAP K +E AP +
Sbjct: 448 KP-------------APTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTT 492
Query: 272 RRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSI 331
+ P TT T EPS TTT+E P +P+P T + P++ +P +
Sbjct: 493 TKEPAPTTTKSAPTTPKEPS-PTTTKEPAPTTPK---EPAPTTPKKPAPTTPKEPAPTTP 548
Query: 332 TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSG 391
P+ T A + K TA K L+ T E P PE A
Sbjct: 549 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT-----TPEKPA--- 600
Query: 392 PPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQY 451
PT P L + + E P AA P P+P +P
Sbjct: 601 -PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK-----------EPAPTTPKEPA 648
Query: 452 SILREEREAELDSELI--IESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEER 509
+E E A + +E P K A +E T ++
Sbjct: 649 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 708
Query: 510 APSR-RGLAEPGSFLDYPSTEPQPGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAA 566
AP+ +G A P+T +P P P G L+ P P+KP + +P
Sbjct: 709 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTT 765
Query: 567 TKGPGPLGPGAPPP 580
TKGP P P
Sbjct: 766 TKGPTSTTSDKPAP 779
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/309 (20%), Positives = 114/309 (36%), Gaps = 37/309 (11%)
Query: 278 TTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITP---- 333
TTP K+T T E TT ++ P + +P+ T EP +P + P
Sbjct: 578 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 637
Query: 334 ---PSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS 390
P++ EP+ + + E TA KG + T + P P P+ A
Sbjct: 638 EPAPTTPKEPAPTTPKEPAPTTPKE--TAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-- 693
Query: 391 GPPTIPSP----LDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
P T P D A + G + P ++ P+ P+P +
Sbjct: 694 -PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 752
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRA 506
P ++ EL + + ++++ + +P +++ P P +E
Sbjct: 753 P-------KKPAPKEL-APTTTKGPTSTTSDKPAPTTPKETAPTTP------KEPAPTTP 798
Query: 507 EERAPSRRGLAEP-GSFLDYPSTEPQP-----GPELPPGDGALEPETPMLPRKPEEDS-S 559
++ AP+ P S + P+T +P P+ + + EP L P+E
Sbjct: 799 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 858
Query: 560 SNQSPAATK 568
+ ++PAATK
Sbjct: 859 TTKTPAATK 867
Score = 33.1 bits (74), Expect = 1.0
Identities = 50/225 (22%), Positives = 80/225 (35%), Gaps = 22/225 (9%)
Query: 129 KENGHVTISE-SPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLD 187
KE T E +P P P+ P+ P + S+ T E T ++K +
Sbjct: 783 KETAPTTPKEPAPTTPKKPAPTTPETPPPTT-----SEVSTPTTTKEPTTIHKSPDESTP 837
Query: 188 QMKAEAYKYIDITRPEE-----VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKP 242
++ AE P+E K PE+ D K + D+ PE K
Sbjct: 838 ELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD-KTTERDLRTTPETTTAAPKM 896
Query: 243 APVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITL---TEIEPSVETTTQEK 299
E++T + ++ Q TTP KIT T + P V TT +K
Sbjct: 897 TKETATTT-----EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV--TTTKK 949
Query: 300 TPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAE 344
T +I KP P + + +P P + +P++ +
Sbjct: 950 TITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 994
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 57.4 bits (137), Expect = 5e-08
Identities = 84/444 (18%), Positives = 156/444 (35%), Gaps = 54/444 (12%)
Query: 145 TPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEE 204
TP P + D G GL + D + +T+ NK+ P IT +
Sbjct: 213 TPKPPVVDEAG---SGLDNGDFKVTTPDTSTTQHNKVSTSP------------KITTAKP 257
Query: 205 VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYI 264
+ + P + + + +++ + +K +GK E++T A
Sbjct: 258 INPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK-------EKTTSAKET 310
Query: 265 DDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEK---TPEKQDICLKPSPDTVPTVTVS 321
+ ++ + + P L + P ETTT+ TP++ P+P T +
Sbjct: 311 QSI---EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE------PTPTTPKEPAST 361
Query: 322 EPEDDSPGSI-TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQL 380
P++ +P +I + P++ EP+ ++ + ++ T KE + T + P P
Sbjct: 362 TPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP---APTTPKEPAPTTTK 418
Query: 381 ADRPEV-KARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGG 439
P K+ P P+P + + + ++P P+
Sbjct: 419 EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 478
Query: 440 PP-PSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAI 498
P P+P +P +E E ++ E SP ++ P +
Sbjct: 479 PKEPAPTAPKKPAPTTPKEPAPTTPKEPA-----PTTTKEPSPTTPKEPAPTTTKSAPTT 533
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPE--TPMLPRKPEE 556
+E + AP+ EP P+T +P P P P+ P P++P
Sbjct: 534 TKEPAPTTTKSAPTTP--KEPS-----PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 586
Query: 557 DSSSNQSPAATKGPGPLGPGAPPP 580
+ +P TK P P P P P
Sbjct: 587 TTPKEPAPTTTKKPAPTTPKEPAP 610
Score = 55.1 bits (131), Expect = 2e-07
Identities = 120/554 (21%), Positives = 173/554 (31%), Gaps = 72/554 (12%)
Query: 34 TPKG--ATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDH 91
TPK T P P +E AS + P +P +++A T +
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPAS----TTPKEPTPTTIKSAPTTPKEPAPTTTK 387
Query: 92 TFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLP 151
+ TT K+ T+ P+E + T KE T +P P P+ P
Sbjct: 388 SAPTTPKE---PAPTTTKEPAPTTPKEPAPTTT----KEPAPTTTKSAPTTPKEPAPTTP 440
Query: 152 DVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQH 211
P + + + E TP E +P T P+E
Sbjct: 441 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP------------TTPKEPAPTAPK 488
Query: 212 HPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQ 271
P + K P +PAP K +E AP +
Sbjct: 489 KP-------------APTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP--APTTTKSAPTT 533
Query: 272 RRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSI 331
+ P TT T EPS TTT+E P +P+P T + P++ +P +
Sbjct: 534 TKEPAPTTTKSAPTTPKEPS-PTTTKEPAPTTPK---EPAPTTPKKPAPTTPKEPAPTTP 589
Query: 332 TPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSG 391
P+ T A + K TA K L+ T E P PE A
Sbjct: 590 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT-----TPEKPA--- 641
Query: 392 PPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQY 451
PT P L + + E P AA P P+P +P
Sbjct: 642 -PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK-----------EPAPTTPKEPA 689
Query: 452 SILREEREAELDSELI--IESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEER 509
+E E A + +E P K A +E T ++
Sbjct: 690 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKP 749
Query: 510 APSR-RGLAEPGSFLDYPSTEPQPGPELPPGDG--ALEPETPMLPRKPEEDSSSNQSPAA 566
AP+ +G A P+T +P P P G L+ P P+KP + +P
Sbjct: 750 APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP---APKELAPTT 806
Query: 567 TKGPGPLGPGAPPP 580
TKGP P P
Sbjct: 807 TKGPTSTTSDKPAP 820
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/309 (20%), Positives = 114/309 (36%), Gaps = 37/309 (11%)
Query: 278 TTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITP---- 333
TTP K+T T E TT ++ P + +P+ T EP +P + P
Sbjct: 619 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 678
Query: 334 ---PSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS 390
P++ EP+ + + E TA KG + T + P P P+ A
Sbjct: 679 EPAPTTPKEPAPTTPKEPAPTTPKE--TAPTTPKGTAPTTLKEPAPTTPKKPAPKELA-- 734
Query: 391 GPPTIPSP----LDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPAS 446
P T P D A + G + P ++ P+ P+P +
Sbjct: 735 -PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT 793
Query: 447 PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRA 506
P ++ EL + + ++++ + +P +++ P P +E
Sbjct: 794 P-------KKPAPKEL-APTTTKGPTSTTSDKPAPTTPKETAPTTP------KEPAPTTP 839
Query: 507 EERAPSRRGLAEP-GSFLDYPSTEPQP-----GPELPPGDGALEPETPMLPRKPEEDS-S 559
++ AP+ P S + P+T +P P+ + + EP L P+E
Sbjct: 840 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVP 899
Query: 560 SNQSPAATK 568
+ ++PAATK
Sbjct: 900 TTKTPAATK 908
Score = 33.1 bits (74), Expect = 1.0
Identities = 50/225 (22%), Positives = 80/225 (35%), Gaps = 22/225 (9%)
Query: 129 KENGHVTISE-SPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLD 187
KE T E +P P P+ P+ P + S+ T E T ++K +
Sbjct: 824 KETAPTTPKEPAPTTPKKPAPTTPETPPPTT-----SEVSTPTTTKEPTTIHKSPDESTP 878
Query: 188 QMKAEAYKYIDITRPEE-----VKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKP 242
++ AE P+E K PE+ D K + D+ PE K
Sbjct: 879 ELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD-KTTERDLRTTPETTTAAPKM 937
Query: 243 APVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITL---TEIEPSVETTTQEK 299
E++T + ++ Q TTP KIT T + P V TT +K
Sbjct: 938 TKETATTT-----EKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKV--TTTKK 990
Query: 300 TPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAE 344
T +I KP P + + +P P + +P++ +
Sbjct: 991 TITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 1035
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 55.5 bits (132), Expect = 2e-07
Identities = 73/309 (23%), Positives = 102/309 (33%), Gaps = 38/309 (12%)
Query: 294 TTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSG--TEPSAAESQGKGSI 351
TT P + PSP PT + P G TPP G T P+A KG +
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGL 1278
Query: 352 SEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGP-PTIPSPLDHEASSAESGD 410
+ A A P P G A P A + P T PSP + G
Sbjct: 1279 ATPPHKGAPNPA------VVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGA 1332
Query: 411 SEIELVSEDPMAAEDALPS-------GYVSFGHVGGPPPSPASPSIQYSILREEREAELD 463
V+ LP+ G + GP P A+PS
Sbjct: 1333 PTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPS------------HKG 1380
Query: 464 SELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPG--- 520
+ + SPK + SP + P + R PS+ L P
Sbjct: 1381 GPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTP 1440
Query: 521 -SFLDYPSTE-PQPGPELPPGDG-----ALEPETPMLPRKPEEDSSSNQSPAATKGPGPL 573
S P+T P+ GP P G A+ P +P P P++ ++S+ A P P+
Sbjct: 1441 VSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM 1500
Query: 574 GPGAPPPLL 582
G P ++
Sbjct: 1501 GAPTLPAVI 1509
Score = 51.6 bits (122), Expect = 3e-06
Identities = 69/292 (23%), Positives = 94/292 (32%), Gaps = 48/292 (16%)
Query: 294 TTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSG--TEPSAAESQGKGSI 351
TT P + P P PT + P G TPP G T P+A KG +
Sbjct: 1127 TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1186
Query: 352 SEDELITAIKEAKGL-SYETAENPRPVGQLADRPEVKARSGP-PTIPSPLDHEASSAESG 409
A KG + A P P G LA A + P T PSP A+ + G
Sbjct: 1187 -------ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKG 1239
Query: 410 DSEIELVSEDPMAAEDALPSGYVSFGHVGGP-PPSPASPSIQYSILREEREAELDSELII 468
P A + G + G P PP+ PS++ + + + ++
Sbjct: 1240 ------APTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVT 1293
Query: 469 ESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPST 528
+ PK P P PS +G P T
Sbjct: 1294 PPSPKGGPATSPPKGAPTPPAATP------------------PSPKG---------SPGT 1326
Query: 529 EPQPGPELPPGDGALEPE-TPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPP 579
P G PP P+ TP LP +P++ +GP P P A P
Sbjct: 1327 PPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTP--PAATP 1376
Score = 48.1 bits (113), Expect = 3e-05
Identities = 94/395 (23%), Positives = 123/395 (31%), Gaps = 52/395 (13%)
Query: 231 IKPEGVREPDKPAPVEGKIIKDHLLEESTF-----APYIDDLSEEQRRAPQITTPVKITL 285
+ P+GV P K P + E AP + S ++A P I
Sbjct: 873 LSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPA 932
Query: 286 TEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSG--TEPSAA 343
+ T P + PSP PT + P G TP G T P+A
Sbjct: 933 SPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAAT 992
Query: 344 ESQGKGSISEDELITAIKEAKGLSYETAENP-RPVGQLADRPEVKARSGPP--TIPSPLD 400
KG A KG A P P G A P K S PP T PSP
Sbjct: 993 PPSPKGG-------PATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKG 1045
Query: 401 HEAS----------------SAESGDSEIELV-SEDPMAAEDALPSGYVSFGHVGGPPPS 443
A+ S + G + L + P AA P G + G P
Sbjct: 1046 SPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMP 1105
Query: 444 PAS--PSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSP---PMKPSALDAI 498
PA+ PS + + + + + PK +P P P A
Sbjct: 1106 PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLAT 1165
Query: 499 REETGVRAEERA--PSRRG-LAEP---GSFLDYPSTEPQP-------GPELPPGDGALEP 545
G A PS +G LA P G+ +T P P P+ P A P
Sbjct: 1166 PPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP 1225
Query: 546 ETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 580
+P + +PAAT GP PPP
Sbjct: 1226 PSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPP 1260
Score = 35.8 bits (81), Expect = 0.16
Identities = 114/562 (20%), Positives = 186/562 (33%), Gaps = 119/562 (21%)
Query: 35 PKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFS 94
PKGA P A PSP G+ P + +P G T
Sbjct: 1306 PKGAPTPPAATPPSP----------KGSPGTPPPKGAPTPPAVTPPSPKGTP-----TLP 1350
Query: 95 TTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVP 154
T+ +G T + PP ++ + G SP+ GP++P
Sbjct: 1351 ATTPSSKGGPTTPSSKEGPTPPAATPSH-------KGGPAMTPPSPKR----GPAIP--- 1396
Query: 155 GIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEV-----KHQE 209
+G +S + I ++P K A P+ + A D+T P K
Sbjct: 1397 --SPKGDPTSPAVIPLSP------KKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPA 1448
Query: 210 QHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSE 269
P+ K T ++ P +EP PAP + +T AP
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKEP--PAPKQVATSSSPKKAPATPAP------- 1499
Query: 270 EQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTV--------PTVTVS 321
AP + + + E+ P+ ++ ++ + K +P T+ P +TV
Sbjct: 1500 --MGAPTLPAVIPSSPKEV-PATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVP 1556
Query: 322 EPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRP--VGQ 379
P+ +P TP + PS+ E+ +++ +Y+ A +P+ +
Sbjct: 1557 SPK-KTPAIPTPKEAPATPSSKEASSPPAVTPS------------TYKGAPSPKELLIPP 1603
Query: 380 LADRPEVKARSGPPTI--PSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHV 437
P K PP + PSP A+ A G V+ P + +D+
Sbjct: 1604 AVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVT--PSSLKDS----------- 1650
Query: 438 GGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDA 497
P SPAS + + AS+ P ++ + +K +
Sbjct: 1651 ---PTSPASVTCKM------------------GATVPQASKGLPAKKGPT-ALKEVLVAP 1688
Query: 498 IREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEED 557
E T + AP+R+G S P P P + G L P P P +
Sbjct: 1689 APESTPIIT---APTRKGPQTKKSSATSPPICPDPSAK-NGSKGPLSTVAP-APLLPVQK 1743
Query: 558 SSSNQSPAATKGPGPLGPGAPP 579
SS + P GP APP
Sbjct: 1744 DSSKTAKGKDASHSPKGPLAPP 1765
Score = 34.3 bits (77), Expect = 0.45
Identities = 71/338 (21%), Positives = 113/338 (33%), Gaps = 68/338 (20%)
Query: 274 APQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITP 333
A +T+P+ + + SV T P+ LK S T PTV E P + P
Sbjct: 605 ASSMTSPLGVNSSA---SVIKTDSYAGPDSAGPLLKSSLIT-PTVAAFPLESADPAGVAP 660
Query: 334 PSS---------------GTEPSAAESQG--KGSISEDELITAIKEAKGLSYETAENPRP 376
++ GT A ++ +G+++ L+ E ++ P
Sbjct: 661 TTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAP 720
Query: 377 VGQLADRPEVKARSGPPTIPSP-----------LDHEASSAESGDSEIELVSEDPMAAED 425
+ L PE+ P++P + H ++ A S E +ED A+
Sbjct: 721 LATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASAT 780
Query: 426 ALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQ 485
A G +++ PSP S+ R + SA ++P
Sbjct: 781 ASSKGTLTYL---ADSPSPLGVSVSPQTKRPPTKK-------------GSAGPDTPIGNL 824
Query: 486 DSP--PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGAL 543
SP P++ S L L+ GS D P+T P P P G
Sbjct: 825 SSPVSPVEASFLP----------------ENSLSFQGS-KDSPATTHSPTPPSPKGAPTP 867
Query: 544 EPETPMLPRKPEEDSSSNQSPAATKGPGPL-GPGAPPP 580
TP+ P+ +P+ P P GP P P
Sbjct: 868 SAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAP 905
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 55.1 bits (131), Expect = 2e-07
Identities = 126/504 (25%), Positives = 183/504 (36%), Gaps = 89/504 (17%)
Query: 117 QEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAEST 176
+ D+ Y Q + GHVT S P+E PGP ++ +G+++ P
Sbjct: 384 EPDALYVACQGQPKGGHVT-SMQPKE---PGP-------LQCEAKPLGKAGVQLEPQLEA 432
Query: 177 EVNK---ILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPEL------EDKDLDFKNKDT 227
+N+ +L P + + + + P E EL E L +++
Sbjct: 433 PLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEES 492
Query: 228 DISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKIT--L 285
+S PE P P P LEES +P EE +P + TP+
Sbjct: 493 PLSPPPE--ESPLSPPPESSPFSP---LEESPLSP-----PEESPPSPALETPLSPPPEA 542
Query: 286 TEIEPSVETTTQEKTPEKQDIC-------LKPSPDTVPTVTVSEPEDDSPGSITPPSSGT 338
+ + P E + PE+ L P P+ P +S P ++SP S P +S
Sbjct: 543 SPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESP---MSPPPEESPMSPPPEASRL 599
Query: 339 EPSAAESQGKGSISEDELITAIKEAKGLS------------YETAENPRP-VGQLADRPE 385
P ES E+ ++ EA LS E+ +P P V +L+ P
Sbjct: 600 FPPFEESP-LSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPV 658
Query: 386 VKARSGPPTIPSPLDHEAS-SAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPP-- 442
V +R PP SPL S S E +S P ED+ S PPP
Sbjct: 659 V-SRLSPPPEESPLSPPPEESPTSPPPEASRLSPPP---EDSPTS----------PPPED 704
Query: 443 SPASPSIQYSI----LREEREAELDSELIIESCDASSASEESPKREQD--SPPMKPSALD 496
SPASP + S+ L E L E + C S SP+ E+ SP + L
Sbjct: 705 SPASPPPEDSLMSLPLEESPLLPLPEEP--QLCPRSEGPHLSPRPEEPHLSPRPEEPHLS 762
Query: 497 AIREETGVRAEERAPSRRGLAEPGSF---LDYPSTEPQP-----GPELPPGDGALEPETP 548
EE + + P + E + P PQP P+ + PE P
Sbjct: 763 PQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEP 822
Query: 549 MLPRKPEEDSSSNQSPAATKGPGP 572
L +PEE S QS P P
Sbjct: 823 CLSPQPEESHLSPQSEEPCLSPRP 846
Score = 50.4 bits (119), Expect = 6e-06
Identities = 86/322 (26%), Positives = 120/322 (37%), Gaps = 72/322 (22%)
Query: 287 EIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQ 346
++EP +E E+ P L P P+ P +S P ++SP S P +S P E
Sbjct: 425 QLEPQLEAPLNEEMP------LLPPPEESP---LSPPPEESPTSPPPEASRLSPPPEELP 475
Query: 347 GKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSA 406
+ + EA LS E+P L+ PE S PP
Sbjct: 476 A----------SPLPEALHLSRPLEESP-----LSPPPEESPLSPPPE------------ 508
Query: 407 ESGDSEIELVSEDPMAA-EDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSE 465
S + E P++ E++ PS + P SP SP + S L E EL +
Sbjct: 509 ---SSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPE-ELPTS 564
Query: 466 LIIESCDASSASEESP-----KREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEP- 519
E+ S EESP + SPP + S L EE+ + P L+ P
Sbjct: 565 PPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPP---PEESPLSPPP 621
Query: 520 -GSFLDYP------STEPQPGPELPPGD----------GALEP---ETPMLPRKPEEDSS 559
S L P S P+ P PP + L P E+P+ P PEE +
Sbjct: 622 EASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSP-PPEESPT 680
Query: 560 SNQSPAATKGPGPL-GPGAPPP 580
S A+ P P P +PPP
Sbjct: 681 SPPPEASRLSPPPEDSPTSPPP 702
Score = 45.1 bits (105), Expect = 3e-04
Identities = 97/460 (21%), Positives = 148/460 (32%), Gaps = 85/460 (18%)
Query: 139 SPEELGTPGPSL-----------PDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLD 187
SP E P P+L P P E L S E+ + E +++ P +
Sbjct: 521 SPPEESPPSPALETPLSPPPEASPLSPPFEESPL--SPPPEELPTSPPPEASRLSPPPEE 578
Query: 188 QMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVR-------EPD 240
+ + ++ P E P E+ L +++ +S PE R P
Sbjct: 579 SPMSPPPEESPMSPPPEASRL---FPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPM 635
Query: 241 KPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKT 300
P P E + + + P + LS +P + P E +
Sbjct: 636 SPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESP------------LSPPPEESPTSPP 683
Query: 301 PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAI 360
PE L P P+ PT S P +DSP S PP E + E+ +
Sbjct: 684 PEASR--LSPPPEDSPT---SPPPEDSPAS-PPPEDSLMSLPLEESPLLPLPEEPQLCPR 737
Query: 361 KEAKGLSYETAE---NPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVS 417
E LS E +PRP + P + ++ P + + A + + +
Sbjct: 738 SEGPHLSPRPEEPHLSPRP-----EEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQA 792
Query: 418 EDPMAA---EDALPSGYVSFGHVGGPPPSPA-SPSIQYSILREEREAELDSELIIESCDA 473
E P + E+ S H+ P P SP + S L + E E C +
Sbjct: 793 EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSE---------EPCLS 843
Query: 474 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAP--------------SRRGLAEP 519
E E + PP+ P E A E P L+EP
Sbjct: 844 PRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEP 903
Query: 520 GS---------FLDYPSTEPQPGPELPPGDGALEPETPML 550
G PS EP P+L P D P +P++
Sbjct: 904 GEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPII 943
Score = 34.7 bits (78), Expect = 0.35
Identities = 74/348 (21%), Positives = 123/348 (35%), Gaps = 49/348 (14%)
Query: 256 EESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTP----EKQDICLKPS 311
E++T P + S E P + + S+ T E P + Q + ++P
Sbjct: 4025 EQNTVDPAV---SSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQ 4081
Query: 312 PDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGK-GSISEDELITAIKEAKGLSYET 370
P P+ +P PG S + S G+ GS S E A + +
Sbjct: 4082 PQPQPSSLQLQPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSE-------ASSVPHLL 4134
Query: 371 AENPRPVGQLADRPEVKARS--GP--PTIPSPLDHEASSAESGDSEIELVSEDPMAAEDA 426
A+ P L D+P ++ GP P + P+ + + L S +
Sbjct: 4135 AQ---PSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPV-LQSGQGLPGVGI 4190
Query: 427 LPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQD 486
+P+ G + + + Q L +++ +L + L+ S A ++P ++
Sbjct: 4191 MPT----VGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQE- 4245
Query: 487 SPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALE-- 544
P + S L + P L E G+ PQ P LP GAL
Sbjct: 4246 -PGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGA-----GPRPQGPPRLPAPPGALSTG 4299
Query: 545 -----------PETPMLPRKPEE-DSSSNQSPAATKGPGPLGPGAPPP 580
P +P P++P + S S+Q P + P P PG P P
Sbjct: 4300 PVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLP-PTHPGTPKP 4346
Score = 33.9 bits (76), Expect = 0.59
Identities = 78/330 (23%), Positives = 121/330 (36%), Gaps = 49/330 (14%)
Query: 257 ESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTV- 315
E F D E AP + TP+ P T E P + L PSP +
Sbjct: 958 EYPFGAKGDSDPESPLAAPILETPISPP-----PEANCTDPEPVPP---MILPPSPGSPV 1009
Query: 316 ----PTVTVSEPEDDSP---GSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSY 368
P + P SP S+ P +S P + S +S ++ I + G+S
Sbjct: 1010 GPASPILMEPLPPQCSPLLQHSLVPQNS---PPSQCSPPALPLSVPSPLSPIGKVVGVSD 1066
Query: 369 ETAENPRPVGQLADRPEVKARSGPPT--IPSPLDHEASSAESGDSEIELVSEDPMAAEDA 426
E AE + PE A T +PSP+ + A S ++ S ED
Sbjct: 1067 E-AELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSG---LGEDT 1122
Query: 427 LP-SGYVSFGHVGGPPPSPASPSIQYS----ILREEREAELDSELIIESCDASSASEESP 481
P G + G P +P S + + +L E A + + C +A + SP
Sbjct: 1123 APLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECK-QTAGQGSP 1181
Query: 482 KREQDSP--PMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPG 539
EQ+ P P+ P+ I+ + L++ + +P +EP G P G
Sbjct: 1182 CEEQEEPRAPVAPTPPTLIKSDI-------VNEISNLSQGDASASFPGSEPLLGSPDPEG 1234
Query: 540 DGALEPETPMLPRKPEEDSSSNQSPAATKG 569
G+L E + S++ SPA +G
Sbjct: 1235 GGSLSMELGV---------STDVSPARDEG 1255
Score = 33.5 bits (75), Expect = 0.77
Identities = 45/187 (24%), Positives = 67/187 (35%), Gaps = 15/187 (8%)
Query: 397 SPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPP--SPASPSIQYSI- 453
+P+ S E GD+ + +A + G+V+ P P A P + +
Sbjct: 366 TPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQ 425
Query: 454 LREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSR 513
L + EA L+ E+ + S P+ SPP + S L EE +P
Sbjct: 426 LEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPA-----SPLP 480
Query: 514 RGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPL 573
L L P E P PP + L P P P E+S + + P
Sbjct: 481 EAL-----HLSRPLEESPLSP--PPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALE 533
Query: 574 GPGAPPP 580
P +PPP
Sbjct: 534 TPLSPPP 540
Score = 31.6 bits (70), Expect = 2.9
Identities = 43/161 (26%), Positives = 59/161 (36%), Gaps = 28/161 (17%)
Query: 439 GPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAI 498
G P P SP + L + A++ S+ A P PP PS A
Sbjct: 2148 GSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPY-PSPTGAP 2206
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETP---MLPRKPE 555
+ + A SR G +PG F PPG +P TP + PR P
Sbjct: 2207 AQPPMLGAS----SRPGAGQPGEF-----------HTTPPGTPRHQPSTPDPFLKPRCPS 2251
Query: 556 EDSSSNQSPAATKGPGPLGPGAPPPLL----FLNKQKAIDL 592
D+ A + PG G A PLL F +KA+++
Sbjct: 2252 LDNL-----AVPESPGVGGGKASEPLLSPPPFGESRKALEV 2287
Score = 30.0 bits (66), Expect = 8.5
Identities = 56/256 (21%), Positives = 84/256 (32%), Gaps = 37/256 (14%)
Query: 269 EEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPE---D 325
+E +R Q+ +P TE + T TP+ Q L+P P V +
Sbjct: 4315 QEPKRPSQLPSPSSQLPTEAQLP---PTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFS 4371
Query: 326 DSPGSITPPSSGTEPSAAESQGKGSISEDELI-TAIKEAKGLSYETAENPRPVGQLADRP 384
G PP + E E D++ + EA LS + P A
Sbjct: 4372 KGLGPWDPPDNLAETQKPEQSSLVPGHLDQVNGQVVPEASQLSIKQEPREEPCALGAQSV 4431
Query: 385 EVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSP 444
+ +A P P +H + ++ L+ + A L +G S G
Sbjct: 4432 KREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEG--------- 4482
Query: 445 ASPSIQYSILREEREAELDSELI------------IESCDASSASEESPKREQDSPPMKP 492
LR E +DS+L E A PKR Q +
Sbjct: 4483 ---------LRAEINGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLV 4533
Query: 493 SALDAIREETGVRAEE 508
S+ +R+E GVRA E
Sbjct: 4534 SSRKKLRKEDGVRASE 4549
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 53.5 bits (127), Expect = 7e-07
Identities = 91/455 (20%), Positives = 169/455 (37%), Gaps = 46/455 (10%)
Query: 138 ESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYI 197
++ E G P DV E+ G +S TP EV ++ + +AE
Sbjct: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE-SEGAEAPEAEKEAQP 1917
Query: 198 DITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEE 257
+ E ++ + + PE E + + + + + EG +P+ +E + ++ E
Sbjct: 1918 ETESVEALETEGEDEPESEGAEAQ---EAEEAAQEAEGQTQPESEV-IESQEAEEEAQPE 1973
Query: 258 STFAPYIDDLSEEQRRAPQITTPVK-ITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVP 316
S ++ E Q + + + E E ++ +E PE + +P +
Sbjct: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033
Query: 317 TVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRP 376
V + G P S G E AE + + + E ++EA+G ++ +E+
Sbjct: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGE------VQEAEGEAHPESED--- 2084
Query: 377 VGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGH 436
D E + + P E+ E+ ++E E + + A + G
Sbjct: 2085 ----VDAQEAEGEAQP---------ESEGVEAPEAEGEAQKAEGIEAPET--EGEAQPES 2129
Query: 437 VGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEES-PKREQDSPPMKPSAL 495
G P + S E ++AE +++ E +A A EE+ P+ E P
Sbjct: 2130 EGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEG-- 2187
Query: 496 DAIREETGVRAE----ERAPSRRGLAEPGSFLDYPSTEPQP-GPELPPGDGALEPETPML 550
+A E G+ A E P G+ P + +P+P G E P +G +PE+
Sbjct: 2188 EAQPESEGIEAPEAEGEAQPELEGVEAPEA---EEEAQPEPEGVETPEAEGEAQPESEGE 2244
Query: 551 PR-----KPEEDSSSNQSPAATKGPGPLGPGAPPP 580
+ P+ QS A++ P+ P P
Sbjct: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP 2279
Score = 48.5 bits (114), Expect = 2e-05
Identities = 123/597 (20%), Positives = 210/597 (35%), Gaps = 65/597 (10%)
Query: 26 GEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGV 85
G+G +G A +P GA EA E + P + A E
Sbjct: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE 1864
Query: 86 SSAMDHTFSTTSKDGEGSCYTSLISDICYPPQE----DSTYFTGILQKENGHVTISESPE 141
A + + + EG D+ P E + + E +ES E
Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPES-EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE 1923
Query: 142 ELGTPGPSLPDVPGIESRGLFSSDSGIE-MTPAESTEVNKILADPLDQMKAEAYKYIDIT 200
L T G P+ G E++ + E T ES + A+ Q ++E + +++
Sbjct: 1924 ALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV- 1982
Query: 201 RPEEVKHQE---QHHPELEDKDL-----DFKNKDTDISIKPEGVREPDKPAPVEGKIIKD 252
EV+ QE + PE ED + + + + + + +GV K E + ++
Sbjct: 1983 ---EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG 2039
Query: 253 HLLE-ESTFAPYIDDLS--EEQRRAPQITTPVKITLTEIEPSVETTTQEKT-----PEKQ 304
+ E P D + E + A + V+ E P E ++ PE +
Sbjct: 2040 ETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESE 2099
Query: 305 DI-CLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGK----GSISEDELITA 359
+ + + + PE + G P S G E AE + + G ++D A
Sbjct: 2100 GVEAPEAEGEAQKAEGIEAPETE--GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEA 2157
Query: 360 IKEAKGL-SYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVS- 417
E++G+ + E E +P + + PE + + P + EA AE G+++ EL
Sbjct: 2158 QPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI----EAPEAE-GEAQPELEGV 2212
Query: 418 EDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSAS 477
E P A E+A P G P + S + E + ++ + + AS
Sbjct: 2213 EAPEAEEEAQPEPE------GVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEAS 2266
Query: 478 EESPKREQDSPPMKPS-ALDAIREETGVR---AEERAPSRRGLAEPGSFLDY-------- 525
E S +D P PS D + G + + RA S + S D+
Sbjct: 2267 ESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSP 2326
Query: 526 -------PSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGP 575
P E + P + + E P+ R PE+ +S + G L P
Sbjct: 2327 DAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAP 2383
Score = 30.4 bits (67), Expect = 6.5
Identities = 36/175 (20%), Positives = 64/175 (36%), Gaps = 5/175 (2%)
Query: 402 EASSAESGDSEIELVSEDPMAA--EDALPSGYVSFGHVGGPPPSPASPSIQYSILREERE 459
E + ++++E + E E+ + V G GG ++ L EE
Sbjct: 1345 EGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGS 1404
Query: 460 AELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEP 519
S D + E+ P +E+++ SA E G PS +P
Sbjct: 1405 VHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAE--GTEEPTEPPSHLSETDP 1462
Query: 520 GSFLDYPSTEPQPGPELPPGDGALEPE-TPMLPRKPEEDSSSNQSPAATKGPGPL 573
+ ++ +PG E PPG + E T P + + SS+ + +A P+
Sbjct: 1463 SASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPI 1517
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 52.0 bits (123), Expect = 2e-06
Identities = 116/555 (20%), Positives = 188/555 (33%), Gaps = 88/555 (15%)
Query: 27 EGENEAVTP---KGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVA 83
E E E P K A PA + G P A+A E++S E S + + GV
Sbjct: 92 EEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVK 151
Query: 84 GVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEEL 143
+ A K + S S S PP+ T + K +++P +
Sbjct: 152 PQAKAA----KAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ-----TKAPPKP 202
Query: 144 GTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEA-YKYIDITRP 202
P + + S SS S + + E P Q+ A+A K
Sbjct: 203 ARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR 262
Query: 203 EEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAP 262
+ ++ E E++ KNK S P P P P +
Sbjct: 263 KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPP----PSAPPPKKSLG------------- 305
Query: 263 YIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSE 322
++ ++A + PV+ + + S ++ +EK P + + K + P +E
Sbjct: 306 -----TQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 323 PEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLAD 382
DS S +E A S+ G+ A+ A +PVG
Sbjct: 361 SSSDS-----SDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK 415
Query: 383 RPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPP 442
KA S S + E+SS+E ++ + + P A A S
Sbjct: 416 LLTRKADS------SSSEEESSSSEEEKTKKMVATTKPKATAKAALS------------- 456
Query: 443 SPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREET 502
PA + Q S R++ DS D+SS+ EE K + + KP +
Sbjct: 457 LPAKQAPQGS-----RDSSSDS-------DSSSSEEEEEKTSKSAVKKKPQKVAG----- 499
Query: 503 GVRAEERAPSRRGLAEP--GSFLDYPSTEPQ--------PGPELPPGDG--ALEPETPML 550
G + A +++G AE S D S E + P P+ P +G AL +
Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKA 559
Query: 551 PRKPEEDSSSNQSPA 565
+ EE+ + A
Sbjct: 560 AKNSEEEEEEKKKAA 574
Score = 52.0 bits (123), Expect = 2e-06
Identities = 65/295 (22%), Positives = 121/295 (41%), Gaps = 54/295 (18%)
Query: 293 ETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSIS 352
+++++++ P+ Q K +P TV T + P+ P P + + +++ S S S
Sbjct: 172 DSSSEDEPPKNQKP--KITPVTVKAQTKAPPK---PARAAPKIANGKAASSSSSSSSSSS 226
Query: 353 EDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSE 412
D+ +E K + T + P Q+ + VKA + P ++SS+E S+
Sbjct: 227 SDDS----EEEKAAA--TPKKTVPKKQVVAKAPVKAATTPT-------RKSSSSEDSSSD 273
Query: 413 IELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCD 472
E + PM + P Y S P P++P + S+ + + ++ + +ES +
Sbjct: 274 EEEEQKKPMKNK---PGPYSSV-------PPPSAPPPKKSLGTQPPKKAVEKQQPVESSE 323
Query: 473 ASSASEESPKREQDSPPMK----------PSALDAIR-----EETGVRAEERAPS----- 512
SS +S E+ PP K P A A ++ ++ APS
Sbjct: 324 DSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGT 383
Query: 513 -RRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAA 566
+ +P P+ +P P+ P G G +L RK + SS +S ++
Sbjct: 384 TKNSSNKPAVTTKSPAVKPAAAPKQPVGGG-----QKLLTRKADSSSSEEESSSS 433
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 51.6 bits (122), Expect = 3e-06
Identities = 75/295 (25%), Positives = 116/295 (39%), Gaps = 64/295 (21%)
Query: 116 PQEDSTYFTGILQKENGHV-----TISESPEELGTPGPSLPD--------VPGIESRGLF 162
P + Y G + + H+ + S+SPE L PGP+L D VPG++ R
Sbjct: 1298 PSGNGKYLPGAITSPDEHILTPDSSFSKSPESL--PGPALEDIAIKWEDKVPGLKDR--- 1352
Query: 163 SSDSGIEMTPAES-------TEVNKILADPLD----------QMKAEAYKYIDITRPEEV 205
+S+ E P + T +K + +P D +K EA K D ++
Sbjct: 1353 TSEQKKEPEPKDEVLQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKG 1412
Query: 206 KHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKII--KDHLLEESTFA-- 261
+ EQ LE KD + KD D+ K + + + DK + K + KD LE+ A
Sbjct: 1413 RDLEQKDTALEQKDKALEPKDKDLEEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALE 1472
Query: 262 PYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTV----PT 317
P DL ++ R Q +EK PE++D L +V P
Sbjct: 1473 PKDKDLEQKDRVLEQ--------------------KEKIPEEKDKALDQKVRSVEHKAPE 1512
Query: 318 VTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAE 372
TV+E +D T + + A E + K S +D+ + A G E E
Sbjct: 1513 DTVAEMKDRDLEQ-TDKAPEQKHQAQEQKDKVSEKKDQALEQKYWALGQKDEALE 1566
Score = 37.7 bits (86), Expect = 0.041
Identities = 74/316 (23%), Positives = 111/316 (35%), Gaps = 43/316 (13%)
Query: 279 TPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGT 338
+P+ + E E + + P+K K P+ + +EPE P P
Sbjct: 1903 SPLGKDYRKAEGEREEEGRAEAPDKSSHSSKV-PEASKSHATTEPEQTEPEQREPTPYPD 1961
Query: 339 EPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSP 398
E S + I E ++T GL P+G D P P
Sbjct: 1962 ERSFQYAD----IYEQMMLT------GLGPACPTREPPLGAAGDWP-----------PCL 2000
Query: 399 LDHEASSAESGDSEIELVSE-DPMAAEDALPSGYVSFGHVGGP--PPSPA-SPSIQYS-- 452
EA++ + +E EL S P + + P+ S+ + GP PP P PS++ S
Sbjct: 2001 STKEAAAGRNTSAEKELSSPISPKSLQSDTPT--FSYAALAGPTVPPRPEPGPSMEPSLT 2058
Query: 453 ---------ILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETG 503
IL + L+ ++ S D S S + R S L+ E
Sbjct: 2059 PPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQP 2118
Query: 504 VRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQS 563
+ E ++PS GS +P TE P L D L P P L S+
Sbjct: 2119 EK-EAQSPSPPHPIPMGSPTLWPETEAHVSPPL---DSHLGPARPSLDFPASAFGFSSLQ 2174
Query: 564 PAATKGPGPLGPGAPP 579
PA + P P P + P
Sbjct: 2175 PAPPQLPSPAEPRSAP 2190
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 51.6 bits (122), Expect = 3e-06
Identities = 79/305 (25%), Positives = 107/305 (35%), Gaps = 81/305 (26%)
Query: 316 PTVTVSEPEDDSPGSITPPSSGTE-PSAAESQGKGSISEDELITAIKEAKGLSYETAENP 374
P +PE++S S S E P+ SQ K S ++ A AKG + A P
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA-TP 317
Query: 375 RPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVS- 433
P G+ A + ++G P D E+SS ES DSE E + + A SG S
Sbjct: 318 APPGK-AGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAKALLQAKA--SGKTSQ 370
Query: 434 FGHVGGP------------PPSPASPSIQYSILREEREAELDSELIIESCDASSASEESP 481
G P PP P++ + + E D+ S+SEES
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE------------DSQSSSEESD 418
Query: 482 KREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDG 541
E+ KPS +AP R + P + P P P G
Sbjct: 419 SEEEAPAQAKPSG--------------KAPQVRAASAPAK--ESPRKGAAPAPPRKTGPA 462
Query: 542 ALEPETPMLPRKPEEDSSSNQS---------------------------PAATKGPGPLG 574
A + + K EEDS S+ PA+T G GPLG
Sbjct: 463 AAQVQVG----KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 575 PGAPP 579
GA P
Sbjct: 519 KGAGP 523
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/307 (26%), Positives = 113/307 (36%), Gaps = 58/307 (18%)
Query: 291 SVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSP--GSITPPSSGTEPSAAESQGK 348
S E+ ++E+ P + KPS S P +SP G+ P T P+AA+ Q
Sbjct: 414 SEESDSEEEAPAQA----KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-V 468
Query: 349 GSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS----GP------------ 392
G ED ++ + A N V L P+VK S GP
Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 393 --PTIPSPL------DHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHV--GGPPP 442
P PS D E+SS ES D S D P+ S G++ P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSD------SSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 443 SPASPSIQYS---ILREEREAELDSELIIESCDASSASEESP---KREQDSPPMKPSALD 496
SPA Q + ++ + E +D+ E S+ SEE+P Q P +K
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 497 AIREETGVRAEER-APSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 555
A ++T A + AP R G P T P P G + +P
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRK----AGTATSPAGSSPAVAGGTQ--------RPA 690
Query: 556 EDSSSNQ 562
EDSSS++
Sbjct: 691 EDSSSSE 697
Score = 41.2 bits (95), Expect = 0.004
Identities = 85/393 (21%), Positives = 133/393 (33%), Gaps = 66/393 (16%)
Query: 239 PDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQE 298
P K P ++ K E+S + D E Q+ T VK T + P+
Sbjct: 744 PGKTGPTVTQV-KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802
Query: 299 KTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTE--------PSAAESQGKGS 350
K +P V T ++ + SP + PP + P++ S GK
Sbjct: 803 KGTIS-------APGKVVTAA-AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 351 ISEDELITAIKEAKGLSYETAENP---------RPVGQ-------LADRPEVKARSGPPT 394
+ + T +E G S E +++ +P G+ LA E + PT
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 395 IPSPLDHEASSA----ESGDSEIELVS--EDPMAAEDA-LPSGYVSFGHVGGPPPSPASP 447
P A+ A +SG S E S E P A A + + F P PA+
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 448 SIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMK------PSALDAIREE 501
Q R+A S S + P + +P ++ P+A I +
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034
Query: 502 TGVRAEERAPSRRGLAE------PGSFLD-----YPSTEPQPGPELPPGDGALE----PE 546
+ + +++ P + +D P+T PQ G L PE
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPE 1094
Query: 547 TPMLPRKPE-----EDSSSNQSPAATKGPGPLG 574
+ PE EDSS + S + G GP G
Sbjct: 1095 VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQG 1127
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 51.6 bits (122), Expect = 3e-06
Identities = 79/305 (25%), Positives = 107/305 (35%), Gaps = 81/305 (26%)
Query: 316 PTVTVSEPEDDSPGSITPPSSGTE-PSAAESQGKGSISEDELITAIKEAKGLSYETAENP 374
P +PE++S S S E P+ SQ K S ++ A AKG + A P
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA-TP 317
Query: 375 RPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVS- 433
P G+ A + ++G P D E+SS ES DSE E + + A SG S
Sbjct: 318 APPGK-AGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAKALLQAKA--SGKTSQ 370
Query: 434 FGHVGGP------------PPSPASPSIQYSILREEREAELDSELIIESCDASSASEESP 481
G P PP P++ + + E D+ S+SEES
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE------------DSQSSSEESD 418
Query: 482 KREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDG 541
E+ KPS +AP R + P + P P P G
Sbjct: 419 SEEEAPAQAKPSG--------------KAPQVRAASAPAK--ESPRKGAAPAPPRKTGPA 462
Query: 542 ALEPETPMLPRKPEEDSSSNQS---------------------------PAATKGPGPLG 574
A + + K EEDS S+ PA+T G GPLG
Sbjct: 463 AAQVQVG----KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 575 PGAPP 579
GA P
Sbjct: 519 KGAGP 523
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/307 (26%), Positives = 113/307 (36%), Gaps = 58/307 (18%)
Query: 291 SVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSP--GSITPPSSGTEPSAAESQGK 348
S E+ ++E+ P + KPS S P +SP G+ P T P+AA+ Q
Sbjct: 414 SEESDSEEEAPAQA----KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-V 468
Query: 349 GSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS----GP------------ 392
G ED ++ + A N V L P+VK S GP
Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 393 --PTIPSPL------DHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHV--GGPPP 442
P PS D E+SS ES D S D P+ S G++ P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSD------SSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 443 SPASPSIQYS---ILREEREAELDSELIIESCDASSASEESP---KREQDSPPMKPSALD 496
SPA Q + ++ + E +D+ E S+ SEE+P Q P +K
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 497 AIREETGVRAEER-APSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 555
A ++T A + AP R G P T P P G + +P
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRK----AGTATSPAGSSPAVAGGTQ--------RPA 690
Query: 556 EDSSSNQ 562
EDSSS++
Sbjct: 691 EDSSSSE 697
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/295 (25%), Positives = 114/295 (38%), Gaps = 44/295 (14%)
Query: 308 LKPSPDTVPTVTVSEPEDDSP--GSITPPSSGTEPSAAES---QGKGSISEDE------- 355
+KPS T P +SP G+ P T PSAA++ GS SE+
Sbjct: 887 VKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAP 946
Query: 356 -LITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIE 414
+T+ + K N P G A + +A S P + S+A S SE E
Sbjct: 947 AAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA----SESTARSSSSESE 1002
Query: 415 LVSEDPMAAEDALPSGYVSFGHVGGPPPSPA-SPSIQYSILREEREAELDSELIIESCDA 473
ED + A L G + V P P +P + +E+ S+ + A
Sbjct: 1003 --DEDVIPATQCLTPG-IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPA 1059
Query: 474 SSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLD-----YPST 528
+ S+++P S P+ +AL + ++ +E + P R +P S +D P+T
Sbjct: 1060 TQVSKKNPA----SLPLTQAALKVLAQKA---SEAQPPVAR--TQPSSGVDSAVGTLPAT 1110
Query: 529 EPQPGPELPPGDGALE----PETPMLPRKPE-----EDSSSNQSPAATKGPGPLG 574
PQ G L PE + PE EDSS + S + G GP G
Sbjct: 1111 SPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQG 1165
Score = 35.0 bits (79), Expect = 0.27
Identities = 57/232 (24%), Positives = 87/232 (37%), Gaps = 45/232 (19%)
Query: 333 PPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGP 392
PP + T+PS+ G++ + +AKG T + +P PEV+ +
Sbjct: 1089 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKG----TNKLRKP-----KLPEVQQATKA 1139
Query: 393 PTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYS 452
P S D E SS S SE + E P A+ A H GP PS +
Sbjct: 1140 P--ESSDDSEDSSDSSSGSEED--GEGPQGAKSA---------HTLGPTPS------RTE 1180
Query: 453 ILREEREAELDSELIIESCDA--------------SSASEESPKREQDSPPMKPSALDAI 498
L EE AE + ++ + S AS+ +PK DS P S L A
Sbjct: 1181 TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK--LDSSPSVSSTL-AA 1237
Query: 499 REETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPML 550
+++ + E + G+ P + ++ P P GA P+ L
Sbjct: 1238 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTL 1289
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 51.6 bits (122), Expect = 3e-06
Identities = 79/305 (25%), Positives = 107/305 (35%), Gaps = 81/305 (26%)
Query: 316 PTVTVSEPEDDSPGSITPPSSGTE-PSAAESQGKGSISEDELITAIKEAKGLSYETAENP 374
P +PE++S S S E P+ SQ K S ++ A AKG + A P
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA-TP 317
Query: 375 RPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVS- 433
P G+ A + ++G P D E+SS ES DSE E + + A SG S
Sbjct: 318 APPGK-AGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAKALLQAKA--SGKTSQ 370
Query: 434 FGHVGGP------------PPSPASPSIQYSILREEREAELDSELIIESCDASSASEESP 481
G P PP P++ + + E D+ S+SEES
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE------------DSQSSSEESD 418
Query: 482 KREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDG 541
E+ KPS +AP R + P + P P P G
Sbjct: 419 SEEEAPAQAKPSG--------------KAPQVRAASAPAK--ESPRKGAAPAPPRKTGPA 462
Query: 542 ALEPETPMLPRKPEEDSSSNQS---------------------------PAATKGPGPLG 574
A + + K EEDS S+ PA+T G GPLG
Sbjct: 463 AAQVQVG----KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 575 PGAPP 579
GA P
Sbjct: 519 KGAGP 523
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/307 (26%), Positives = 113/307 (36%), Gaps = 58/307 (18%)
Query: 291 SVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSP--GSITPPSSGTEPSAAESQGK 348
S E+ ++E+ P + KPS S P +SP G+ P T P+AA+ Q
Sbjct: 414 SEESDSEEEAPAQA----KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-V 468
Query: 349 GSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS----GP------------ 392
G ED ++ + A N V L P+VK S GP
Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 393 --PTIPSPL------DHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHV--GGPPP 442
P PS D E+SS ES D S D P+ S G++ P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSD------SSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 443 SPASPSIQYS---ILREEREAELDSELIIESCDASSASEESP---KREQDSPPMKPSALD 496
SPA Q + ++ + E +D+ E S+ SEE+P Q P +K
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 497 AIREETGVRAEER-APSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 555
A ++T A + AP R G P T P P G + +P
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRK----AGTATSPAGSSPAVAGGTQ--------RPA 690
Query: 556 EDSSSNQ 562
EDSSS++
Sbjct: 691 EDSSSSE 697
Score = 41.2 bits (95), Expect = 0.004
Identities = 85/393 (21%), Positives = 133/393 (33%), Gaps = 66/393 (16%)
Query: 239 PDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQE 298
P K P ++ K E+S + D E Q+ T VK T + P+
Sbjct: 744 PGKTGPTVTQV-KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802
Query: 299 KTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTE--------PSAAESQGKGS 350
K +P V T ++ + SP + PP + P++ S GK
Sbjct: 803 KGTIS-------APGKVVTAA-AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
Query: 351 ISEDELITAIKEAKGLSYETAENP---------RPVGQ-------LADRPEVKARSGPPT 394
+ + T +E G S E +++ +P G+ LA E + PT
Sbjct: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT 914
Query: 395 IPSPLDHEASSA----ESGDSEIELVS--EDPMAAEDA-LPSGYVSFGHVGGPPPSPASP 447
P A+ A +SG S E S E P A A + + F P PA+
Sbjct: 915 PPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 448 SIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMK------PSALDAIREE 501
Q R+A S S + P + +P ++ P+A I +
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPK 1034
Query: 502 TGVRAEERAPSRRGLAE------PGSFLD-----YPSTEPQPGPELPPGDGALE----PE 546
+ + +++ P + +D P+T PQ G L PE
Sbjct: 1035 ASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPE 1094
Query: 547 TPMLPRKPE-----EDSSSNQSPAATKGPGPLG 574
+ PE EDSS + S + G GP G
Sbjct: 1095 VQQATKAPESSDDSEDSSDSSSGSEEDGEGPQG 1127
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 51.6 bits (122), Expect = 3e-06
Identities = 79/305 (25%), Positives = 107/305 (35%), Gaps = 81/305 (26%)
Query: 316 PTVTVSEPEDDSPGSITPPSSGTE-PSAAESQGKGSISEDELITAIKEAKGLSYETAENP 374
P +PE++S S S E P+ SQ K S ++ A AKG + A P
Sbjct: 259 PAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA-TP 317
Query: 375 RPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVS- 433
P G+ A + ++G P D E+SS ES DSE E + + A SG S
Sbjct: 318 APPGK-AGAVASQTKAGKPEE----DSESSSEESSDSEEETPAAKALLQAKA--SGKTSQ 370
Query: 434 FGHVGGP------------PPSPASPSIQYSILREEREAELDSELIIESCDASSASEESP 481
G P PP P++ + + E D+ S+SEES
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE------------DSQSSSEESD 418
Query: 482 KREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDG 541
E+ KPS +AP R + P + P P P G
Sbjct: 419 SEEEAPAQAKPSG--------------KAPQVRAASAPAK--ESPRKGAAPAPPRKTGPA 462
Query: 542 ALEPETPMLPRKPEEDSSSNQS---------------------------PAATKGPGPLG 574
A + + K EEDS S+ PA+T G GPLG
Sbjct: 463 AAQVQVG----KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 575 PGAPP 579
GA P
Sbjct: 519 KGAGP 523
Score = 48.5 bits (114), Expect = 2e-05
Identities = 80/307 (26%), Positives = 113/307 (36%), Gaps = 58/307 (18%)
Query: 291 SVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSP--GSITPPSSGTEPSAAESQGK 348
S E+ ++E+ P + KPS S P +SP G+ P T P+AA+ Q
Sbjct: 414 SEESDSEEEAPAQA----KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ-V 468
Query: 349 GSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARS----GP------------ 392
G ED ++ + A N V L P+VK S GP
Sbjct: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 393 --PTIPSPL------DHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHV--GGPPP 442
P PS D E+SS ES D S D P+ S G++ P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSD------SSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 443 SPASPSIQYS---ILREEREAELDSELIIESCDASSASEESP---KREQDSPPMKPSALD 496
SPA Q + ++ + E +D+ E S+ SEE+P Q P +K
Sbjct: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 497 AIREETGVRAEER-APSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 555
A ++T A + AP R G P T P P G + +P
Sbjct: 643 ACPKKTNTTASAKVAPVRVGTQAPRK----AGTATSPAGSSPAVAGGTQ--------RPA 690
Query: 556 EDSSSNQ 562
EDSSS++
Sbjct: 691 EDSSSSE 697
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 51.2 bits (121), Expect = 4e-06
Identities = 106/463 (22%), Positives = 159/463 (34%), Gaps = 65/463 (14%)
Query: 139 SPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILA--------DPLDQMK 190
S ++L PS + +SR + M P +EVN + A +P D +
Sbjct: 121 SEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLIS 180
Query: 191 AEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKII 250
+ T+ ++V +EQ PE IKP ++P KP P +
Sbjct: 181 DSEASQEETTKKQKVVQKEQGKPEG--------------IIKPPLQQQPPKPIPKQQGPG 226
Query: 251 KDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVET--TTQEKTPEKQDICL 308
+D L ++ T E+ + P T I+ +T T K P ++D
Sbjct: 227 RDPLQQDGTPKSISSQQPEKIKSQPPGTGK------PIQGPTQTPQTDHAKLPLQRDAS- 279
Query: 309 KPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKG-SISEDELITAIKEAKGLS 367
+P V + P PP P +Q G S+ + GL+
Sbjct: 280 RPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLT 339
Query: 368 YETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDAL 427
A+ P V +P V+ PL A+ SE + SE P A
Sbjct: 340 KPLAQQPGTV-----KPPVQPPGTTKPPAQPLGPAKPPAQQTGSE-KPSSEQPGPKALAQ 393
Query: 428 PSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDS 487
P G G P PA P Q + L + S A P +
Sbjct: 394 PPGV---GKTPAQQPGPAKPPTQ--------QVGTPKPLAQQPGLQSPAKAPGPTKTPVQ 442
Query: 488 PPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEP--QPGPELPPGD--GAL 543
P P + A + G + ++ G +P S L P+ P QPGP PP G+
Sbjct: 443 QP-GPGKIPAQQAGPGKTSAQQT----GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSA 497
Query: 544 EP------ETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 580
+P T P++P S Q P +TK P PG+ P
Sbjct: 498 KPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ-QPGSAKP 539
Score = 45.4 bits (106), Expect = 2e-04
Identities = 126/617 (20%), Positives = 208/617 (33%), Gaps = 110/617 (17%)
Query: 16 GPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSG----PARQS 71
GP + G + + P A P+ Q P+ ++ + S + GSG P S
Sbjct: 515 GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS-QTGSGKPLQPPTVS 573
Query: 72 PVAMETASTGV-------AGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFT 124
P A + S G+ + + H + + C T++ S + P T
Sbjct: 574 PSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLT--- 630
Query: 125 GILQKENGHVTISESPEELG---TPGPSLPDVPGIESRGLFSSDSGIEMTPA-ESTEVNK 180
+ + + LG P PS P P +++ + ++ + + +P + T K
Sbjct: 631 ---EVKEWLCLNCQMKRALGGDLAPVPSSPQ-PKLKTAPVTTTSAVSKSSPQPQQTSPKK 686
Query: 181 ILADPLDQMKAEAYKYIDITRPEEVKHQEQH-HPELEDKDLDFKNKDTDISIKPEGVREP 239
A D KA K P VK H P + K + + D KP +EP
Sbjct: 687 DAAPKQDLSKAPEPK----KPPPLVKQPTLHGSPSAKAK----QPPEADSLSKPAPPKEP 738
Query: 240 DKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPS-----VET 294
P+ E AP DD ++ + T V + +P V++
Sbjct: 739 SVPS-------------EQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQS 785
Query: 295 TTQEKT--PEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSIS 352
+EKT P K D KPS PT P D +I P+S ++ + S
Sbjct: 786 QAEEKTTPPLKTDSA-KPSQSFPPTGEKVSPFDSK--AIPRPASDSKIISHPGPSSESKG 842
Query: 353 EDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPP--------TIPSPLDHEAS 404
+ ++ K+ + +T +P+P +P K PP T+P+P
Sbjct: 843 QKQVDPVQKKEEPKKAQTKMSPKPDA----KPMPKGSPTPPGPRPTAGQTVPTPQQSPKP 898
Query: 405 SAESGDSEIELVS------EDPMAAEDALPSGYVSFGH------------VGGPPP---- 442
+S + L S P ++ + FG G P P
Sbjct: 899 QEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQS 958
Query: 443 SPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREET 502
P +P ++A S+ S+ PK +PP ++ +E
Sbjct: 959 GPGAPM---------KQAPAPSQ--------PPTSQGPPKSTGQAPPAPAKSIPVKKETK 1001
Query: 503 GVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQ 562
AE+ P AE + TE +P P EP+ +LP K E+
Sbjct: 1002 APAAEKLEPK----AEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057
Query: 563 SPAATKGPGPLGPGAPP 579
+ K +G PP
Sbjct: 1058 TCPLCKTELNIGSKDPP 1074
Score = 44.3 bits (103), Expect = 4e-04
Identities = 78/379 (20%), Positives = 131/379 (34%), Gaps = 67/379 (17%)
Query: 261 APYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTV 320
AP + + AP +TT ++ + +P +T+ ++ KQD+ P P P +
Sbjct: 651 APVPSSPQPKLKTAP-VTTTSAVSKSSPQPQ-QTSPKKDAAPKQDLSKAPEPKKPPPLVK 708
Query: 321 SEPEDDSPG----------SITPPSSGTEPSAAESQGKGSISEDE-----LITAIKEAKG 365
SP S++ P+ EPS Q K +++D+ ++ +
Sbjct: 709 QPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVS 768
Query: 366 LSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAED 425
S T + P ++ + E K T P A ++S E VS A
Sbjct: 769 SSSATTKPDIPSSKVQSQAEEK------TTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIP 822
Query: 426 ALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQ 485
S H G P S + Q ++++ E + + DA + PK
Sbjct: 823 RPASDSKIISHPG--PSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDA----KPMPKGSP 876
Query: 486 DSPPMKPSALDAI-REETGVRAEERAPSRRGLAEPGSFLDYPSTEP-------------- 530
P +P+A + + + +E+ SRR GS D P ++P
Sbjct: 877 TPPGPRPTAGQTVPTPQQSPKPQEQ--SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGF 934
Query: 531 ----------------QPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLG 574
QPGP G GA + P + P ++Q P + G P
Sbjct: 935 GASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPP-----TSQGPPKSTGQAPPA 989
Query: 575 PGAPPPLLFLNKQKAIDLL 593
P P+ K A + L
Sbjct: 990 PAKSIPVKKETKAPAAEKL 1008
Score = 35.0 bits (79), Expect = 0.27
Identities = 72/340 (21%), Positives = 117/340 (34%), Gaps = 57/340 (16%)
Query: 261 APYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTV 320
A D S P + + EIE T + T E Q+I S +T
Sbjct: 2114 ASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVT---DYTREIQEIIAHESL----ILTY 2166
Query: 321 SEPEDDS---PGSITPPSSGTEPSAAESQGKGSISE-DELITAIKEAKGL------SYET 370
SEP + + P S TP + + S + I+ D + T E + S E
Sbjct: 2167 SEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMITKFEDSEEI 2226
Query: 371 AENPRPVGQLADRPEVKA----RSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDA 426
+ + G + D PE + R+ PP + DH S S I E
Sbjct: 2227 SSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSI---------IESV 2277
Query: 427 LPSGYVSFGHVGGPPPSPASPSIQYSILREEREA------ELDSELIIESCDASSASEES 480
+P P P + ++ +L E++ E + +I+E +A
Sbjct: 2278 VPK-----------PEGPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYR----- 2321
Query: 481 PKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGD 540
K+E ++ K S + + + + P + L+ + +P +LP G
Sbjct: 2322 DKKELEAERTKSSLSETVFDHPP-SSVIALPMKEQLSTTYFTSGETFGQEKPASQLPSGS 2380
Query: 541 GALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPP 580
P LP KP S+ + + P P P PPP
Sbjct: 2381 ----PSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPP 2416
Score = 34.7 bits (78), Expect = 0.35
Identities = 72/285 (25%), Positives = 106/285 (37%), Gaps = 53/285 (18%)
Query: 242 PAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTP 301
PAP + +K + T AP + L + +AP VK T TE +P ++ T
Sbjct: 988 PAPAKSIPVK-----KETKAPAAEKLEPKAEQAPT----VKRTETEKKPPPIKDSKSLTA 1038
Query: 302 EKQDICLKPSPDTVPTVTVSEPEDDSP--------GSITPPSSGTEPSAAESQ-GKGSIS 352
E Q L + P +PE P GS PP+ T +
Sbjct: 1039 EPQKAVLPTKLEKSP-----KPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFN 1093
Query: 353 EDELITAIKEAKGLSYETAENPRPVGQLAD-RPEVKARSGPPTIPSPLDHEASSAESG-D 410
+T I+E L+ +T GQL D R A SGP P P+ E+SS ++
Sbjct: 1094 PTPHLTEIQEWLCLNCQTQRAIS--GQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVP 1151
Query: 411 SEIELV----SEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSEL 466
+++LV E AE + + PP + Q EE + E D
Sbjct: 1152 PQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQ-----EESKLEKDK-- 1204
Query: 467 IIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAP 511
AS+ E+ P E+ I EE +R+EE+ P
Sbjct: 1205 ------ASALQEKKPLPEEKK---------LIPEEEKIRSEEKKP 1234
Score = 31.2 bits (69), Expect = 3.8
Identities = 79/412 (19%), Positives = 142/412 (34%), Gaps = 85/412 (20%)
Query: 233 PEGVREPDKPAPVEG-----------KIIKDHLLEESTFAPYI------DDLSEEQRRAP 275
P G + P P E K++K E T A + + LS E + P
Sbjct: 1129 PSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSME-KIPP 1187
Query: 276 QITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTV------PTVTVSEPEDDSPG 329
+TT K +++E + QEK P ++ L P + + P + +P +
Sbjct: 1188 MVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDK- 1246
Query: 330 SITPPSSGTEPSAAES---QGKGSISEDEL---ITAIKEAKGLSYETAENPRPVGQLADR 383
+ P + + P + + + I+E++L + +G +T P G
Sbjct: 1247 KLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSL 1306
Query: 384 PE--------VKARSGPPTIPSPLDHEASSAES---GDSEIELVSEDPMAAEDALPSGYV 432
P+ +K + PP P E ++ D S+ P + + +GY
Sbjct: 1307 PKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYS 1366
Query: 433 SFG---HVGGPPP----------------------SPASPS----IQYSILR--EEREAE 461
S G +G P SP+SPS ++ ++L E + +
Sbjct: 1367 SDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQAST 1426
Query: 462 LDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERA----------- 510
L E + S E PK ++ + + + I EE ++E
Sbjct: 1427 LADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQD 1486
Query: 511 -PSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSN 561
PS + E F+D +T +P + + P R+ SSS+
Sbjct: 1487 IPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSS 1538
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.130 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,780,445
Number of Sequences: 37866
Number of extensions: 2221111
Number of successful extensions: 15915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 939
Number of HSP's that attempted gapping in prelim test: 11899
Number of HSP's gapped (non-prelim): 4358
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.