Search of human proteins with 116256350

Search of human proteins with 116256350

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
         (1740 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]           3450   0.0  
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]           3429   0.0  
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]           3416   0.0  
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2...   101   7e-21
gi|118600961 akt substrate AS250 [Homo sapiens]                       101   7e-21
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1...   100   2e-20
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi...    73   2e-12
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi...    73   2e-12
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi...    73   2e-12
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ...    68   9e-11
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ...    68   9e-11
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa...    67   2e-10
gi|112421013 signal-induced proliferation-associated 1 like 2 [H...    67   2e-10
gi|206725526 signal-induced proliferation-associated protein 1 [...    65   8e-10
gi|206725523 signal-induced proliferation-associated protein 1 [...    65   8e-10
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom...    65   8e-10
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho...    63   2e-09
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]            42   0.004
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       42   0.007
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                 41   0.012
gi|145199237 transcription elongation factor B polypeptide 3 bin...    41   0.012
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           40   0.020
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        40   0.020
gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap...    40   0.026
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         39   0.034
gi|223718207 ets variant gene 3 isoform 1 [Homo sapiens]               39   0.044
gi|33620755 YEATS domain containing 2 [Homo sapiens]                   39   0.044
gi|163965366 nascent polypeptide-associated complex alpha subuni...    39   0.044
gi|157738619 smoothelin-like 1 [Homo sapiens]                          39   0.044
gi|110611914 progesterone receptor [Homo sapiens]                      38   0.075

>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
          Length = 1740

 Score = 3450 bits (8947), Expect = 0.0
 Identities = 1740/1740 (100%), Positives = 1740/1740 (100%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD 960
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD 960

Query: 961  ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN 1020
            ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
Sbjct: 961  ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN 1020

Query: 1021 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA 1080
            KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
Sbjct: 1021 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA 1080

Query: 1081 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA 1140
            RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
Sbjct: 1081 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA 1140

Query: 1141 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH 1200
            AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
Sbjct: 1141 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH 1200

Query: 1201 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD 1260
            RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD
Sbjct: 1201 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD 1260

Query: 1261 RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS 1320
            RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS
Sbjct: 1261 RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS 1320

Query: 1321 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS 1380
            SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS
Sbjct: 1321 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS 1380

Query: 1381 SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS 1440
            SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS
Sbjct: 1381 SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS 1440

Query: 1441 PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG 1500
            PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG
Sbjct: 1441 PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG 1500

Query: 1501 SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT 1560
            SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT
Sbjct: 1501 SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT 1560

Query: 1561 KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC 1620
            KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC
Sbjct: 1561 KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC 1620

Query: 1621 RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI 1680
            RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI
Sbjct: 1621 RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI 1680

Query: 1681 KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1740
            KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
Sbjct: 1681 KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1740


>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
          Length = 1784

 Score = 3429 bits (8892), Expect = 0.0
 Identities = 1740/1784 (97%), Positives = 1740/1784 (97%), Gaps = 44/1784 (2%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK               
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960

Query: 946  -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976
                                         RIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020

Query: 977  ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036
            ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080

Query: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096
            LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140

Query: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156
            ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200

Query: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216
            RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260

Query: 1217 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1276
            AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE
Sbjct: 1261 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1320

Query: 1277 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1336
            EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD
Sbjct: 1321 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1380

Query: 1337 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1396
            KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI
Sbjct: 1381 KADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTI 1440

Query: 1397 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1456
            SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE
Sbjct: 1441 SDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNE 1500

Query: 1457 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1516
            SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE
Sbjct: 1501 SQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIE 1560

Query: 1517 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1576
            LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN
Sbjct: 1561 LKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1620

Query: 1577 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1636
            DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV
Sbjct: 1621 DFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIV 1680

Query: 1637 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1696
            SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP
Sbjct: 1681 SDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNP 1740

Query: 1697 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1740
            SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
Sbjct: 1741 SLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV 1784


>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
          Length = 1807

 Score = 3416 bits (8858), Expect = 0.0
 Identities = 1740/1807 (96%), Positives = 1740/1807 (96%), Gaps = 67/1807 (3%)

Query: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60
            MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
Sbjct: 1    MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM 60

Query: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120
            IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
Sbjct: 61   IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR 120

Query: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180
            ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
Sbjct: 121  ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL 180

Query: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240
            VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
Sbjct: 181  VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI 240

Query: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300
            VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
Sbjct: 241  VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG 300

Query: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360
            MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
Sbjct: 301  MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI 360

Query: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420
            LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
Sbjct: 361  LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE 420

Query: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480
            SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
Sbjct: 421  SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY 480

Query: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540
            EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
Sbjct: 481  EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS 540

Query: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600
            PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
Sbjct: 541  PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH 600

Query: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660
            SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
Sbjct: 601  SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS 660

Query: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720
            GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
Sbjct: 661  GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK 720

Query: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780
            VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
Sbjct: 721  VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL 780

Query: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840
            DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
Sbjct: 781  DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA 840

Query: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900
            VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
Sbjct: 841  VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC 900

Query: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK--------------- 945
            RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK               
Sbjct: 901  RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNS 960

Query: 946  -----------------------------RIQTSLTSASLGSADENSVAQADDSLKNLHL 976
                                         RIQTSLTSASLGSADENSVAQADDSLKNLHL
Sbjct: 961  PPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHL 1020

Query: 977  ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1036
            ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL
Sbjct: 1021 ELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSL 1080

Query: 1037 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1096
            LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG
Sbjct: 1081 LGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVG 1140

Query: 1097 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1156
            ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR
Sbjct: 1141 ALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVR 1200

Query: 1157 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1216
            RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST
Sbjct: 1201 RPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAST 1260

Query: 1217 AKPPPLPRSNT-----------------------DSAVVMEEGSPGEVPVLVEPPGLEDV 1253
            AKPPPLPRSNT                       DSAVVMEEGSPGEVPVLVEPPGLEDV
Sbjct: 1261 AKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGSPGEVPVLVEPPGLEDV 1320

Query: 1254 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1313
            EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ
Sbjct: 1321 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1380

Query: 1314 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1373
            PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ
Sbjct: 1381 PLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQ 1440

Query: 1374 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1433
            PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV
Sbjct: 1441 PEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFV 1500

Query: 1434 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1493
            FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA
Sbjct: 1501 FLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELA 1560

Query: 1494 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1553
            ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH
Sbjct: 1561 ILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFH 1620

Query: 1554 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1613
            IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC
Sbjct: 1621 IATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYEC 1680

Query: 1614 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1673
            NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW
Sbjct: 1681 NLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKW 1740

Query: 1674 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1733
            IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV
Sbjct: 1741 IARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSV 1800

Query: 1734 EDFTEFV 1740
            EDFTEFV
Sbjct: 1801 EDFTEFV 1807


>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
            [Homo sapiens]
          Length = 2083

 Score =  101 bits (251), Expect = 7e-21
 Identities = 71/266 (26%), Positives = 130/266 (48%), Gaps = 13/266 (4%)

Query: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512
            L  +++   R ++ LD     +THKIAV YV EGQ +   +IL+N  GS  Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843

Query: 1513 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571
              + L + C     ++GGL      G  T  +    ++ +FH++T MP+ D D     K 
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898

Query: 1572 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1631
            RHLGND V IV+++   D++ G I  +F  V +++ P+      + +  + ++       
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958

Query: 1632 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1691
               IV+ + LP + R  A++A+ A +      +   +Y + +  R R+++ + Q   E  
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012

Query: 1692 AYSNPSLPLVHPPSHSKAPAQTPAEP 1717
             + + +  +  P  +   P+   + P
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPSDAGSYP 2038


>gi|118600961 akt substrate AS250 [Homo sapiens]
          Length = 1873

 Score =  101 bits (251), Expect = 7e-21
 Identities = 66/211 (31%), Positives = 108/211 (51%), Gaps = 7/211 (3%)

Query: 1446 ESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYT 1505
            +  K   L  ++    R ++ LD     +THKIAV Y+ EGQ + + +ILSNE GS  Y 
Sbjct: 1617 DRRKNFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQED-KCSILSNERGSQAYE 1675

Query: 1506 EFLTGLGRLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVD 1564
            +F+ GLG  ++L   C     ++GGL   G  GQ    +    ++ +FH++T MP+ D D
Sbjct: 1676 DFVAGLGWEVDLSTHCG----FMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPS-DSD 1730

Query: 1565 KHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDM 1624
                 K RHLGND V IV+++   D++ G I   F  V +I+ P+      +++  + ++
Sbjct: 1731 DSLTKKLRHLGNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEV 1790

Query: 1625 EGLVDTSVAKIVSDRNLPFVARQMALHANMA 1655
                      IVS + LP +     ++A+ A
Sbjct: 1791 PFFGPLFDGAIVSGKLLPSLVCATCINASRA 1821


>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
            [Homo sapiens]
          Length = 2036

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 70/260 (26%), Positives = 128/260 (49%), Gaps = 13/260 (5%)

Query: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512
            L  +++   R ++ LD     +THKIAV YV EGQ +   +IL+N  GS  Y +F+ GLG
Sbjct: 1785 LLKKNEKLLRELRNLDSRQCRETHKIAVFYVAEGQEDKH-SILTNTGGSQAYEDFVAGLG 1843

Query: 1513 RLIELKD-CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571
              + L + C     ++GGL      G  T  +    ++ +FH++T MP+ D D     K 
Sbjct: 1844 WEVNLTNHCG----FMGGLQKNKSTGLTTPYFATSTVEVIFHVSTRMPS-DSDDSLTKKL 1898

Query: 1572 RHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTS 1631
            RHLGND V IV+++   D++ G I  +F  V +++ P+      + +  + ++       
Sbjct: 1899 RHLGNDEVHIVWSEHTRDYRRGIIPTEFGDVLIVIYPMKNHMFSIQIMKKPEVPFFGPLF 1958

Query: 1632 VAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEA 1691
               IV+ + LP + R  A++A+ A +      +   +Y + +  R R+++ + Q   E  
Sbjct: 1959 DGAIVNGKVLPIMVRATAINASRALK------SLIPLYQNFYEERARYLQTIVQHHLEPT 2012

Query: 1692 AYSNPSLPLVHPPSHSKAPA 1711
             + + +  +  P  +   P+
Sbjct: 2013 TFEDFAAQVFSPAPYHHLPS 2032


>gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens]
          Length = 663

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1450 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1509
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 171  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225

Query: 1510 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1567
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 226  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281

Query: 1568 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1606
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 282  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320


>gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens]
          Length = 727

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1450 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1509
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 235  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 289

Query: 1510 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1567
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 290  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 345

Query: 1568 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1606
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 346  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 384


>gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens]
          Length = 681

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 51/159 (32%), Positives = 82/159 (51%), Gaps = 11/159 (6%)

Query: 1450 PILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1509
            P+L P  S    R +   D+    +  K  V+Y   GQ++ E    +NE  S  + EFL 
Sbjct: 171  PVLYPKAS----RLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEE-SPAFVEFLE 225

Query: 1510 GLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTKDVDKHR 1567
             LG+ ++L+D    K + GGLDV  G+ G +  YC   +  + +FH++T +P  + D  +
Sbjct: 226  FLGQKVKLQDF---KGFRGGLDVTHGQTGTESVYCNFRN-KEIMFHVSTKLPYTEGDAQQ 281

Query: 1568 CDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1606
              +KRH+GND V++V+ D    F    I   F   +V+V
Sbjct: 282  LQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVV 320


>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
            [Homo sapiens]
          Length = 715

 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)

Query: 1450 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1503
            P+L P  SQ           I SYD H      K  V+Y    Q+  E  +  N   S  
Sbjct: 223  PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 271

Query: 1504 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1561
            + EFL  LG  I L+D    K + GGLDV  G+ G +  Y    D  + +FH++T +P  
Sbjct: 272  FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 327

Query: 1562 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1606
            D D  +  +KRH+GND V+I++ +    F    I   F   +++V
Sbjct: 328  DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 372


>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
            [Homo sapiens]
          Length = 730

 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 53/165 (32%), Positives = 77/165 (46%), Gaps = 23/165 (13%)

Query: 1450 PILLPNESQSFERSVQLLDQIPSYDTH------KIAVLYVGEGQSNSELAILSNEHGSYR 1503
            P+L P  SQ           I SYD H      K  V+Y    Q+  E  +  N   S  
Sbjct: 238  PVLYPKASQ----------MIVSYDEHEVNNTFKFGVIYQKARQTLEE-ELFGNNEESPA 286

Query: 1504 YTEFLTGLGRLIELKDCQPDKVYLGGLDVC-GEDG-QFTYCWHDDIMQAVFHIATLMPTK 1561
            + EFL  LG  I L+D    K + GGLDV  G+ G +  Y    D  + +FH++T +P  
Sbjct: 287  FKEFLDLLGDTITLQDF---KGFRGGLDVTHGQTGVESVYTTFRD-REIMFHVSTKLPFT 342

Query: 1562 DVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV 1606
            D D  +  +KRH+GND V+I++ +    F    I   F   +++V
Sbjct: 343  DGDAQQLQRKRHIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVV 387


>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
            sapiens]
          Length = 1013

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 47/153 (30%), Positives = 76/153 (49%), Gaps = 14/153 (9%)

Query: 1461 ERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDC 1520
            ++ + +L++       K  VL+  +GQ   +  + SNE GS  + +FL  LG  I LK  
Sbjct: 188  QKDLLVLEEQEGSVNFKFGVLFAKDGQLTDD-EMFSNEIGSEPFQKFLNLLGDTITLKGW 246

Query: 1521 QPDKVYLGGLDV----CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGN 1576
                 Y GGLD      G    +T     +IM   FH++T++P    +K + ++KRH+GN
Sbjct: 247  TG---YRGGLDTKNDTTGIHSVYTVYQGHEIM---FHVSTMLPYSKENKQQVERKRHIGN 300

Query: 1577 DFVSIVYNDSGED---FKLGTIKGQFNFVHVIV 1606
            D V+IV+ +  E    FK   I+  F  +  +V
Sbjct: 301  DIVTIVFQEGEESSPAFKPSMIRSHFTHIFALV 333


>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
            sapiens]
          Length = 1722

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)

Query: 1455 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1514
            N  +  E+ ++L +Q  S+  HKI +LY   GQS  E  + +NE     + EFL  LG+ 
Sbjct: 587  NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644

Query: 1515 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1573
            + LK     +  L    D  G    +T     ++M   FH++TL+P    ++ +  +KRH
Sbjct: 645  VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701

Query: 1574 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1606
            +GND V+IV+ + G   F   +I+  F  V VIV
Sbjct: 702  IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735


>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)

Query: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512
            L + S    R++  LD+       K+ +LY   GQ + E  + +N+     + +FLT LG
Sbjct: 310  LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368

Query: 1513 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571
             ++ LK  +  +  L    D  G    +T     +IM   FH++T++P    ++ +  +K
Sbjct: 369  DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425

Query: 1572 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1606
            RH+GND V+IV+ + G + F   TI+  F  V ++V
Sbjct: 426  RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461


>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 6/156 (3%)

Query: 1453 LPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLG 1512
            L + S    R++  LD+       K+ +LY   GQ + E  + +N+     + +FLT LG
Sbjct: 310  LGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEE-EMYNNQEAGPAFMQFLTLLG 368

Query: 1513 RLIELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKK 1571
             ++ LK  +  +  L    D  G    +T     +IM   FH++T++P    ++ +  +K
Sbjct: 369  DVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIM---FHVSTMLPYTPNNQQQLLRK 425

Query: 1572 RHLGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1606
            RH+GND V+IV+ + G + F   TI+  F  V ++V
Sbjct: 426  RHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVV 461


>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
            sapiens]
          Length = 1804

 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 48/154 (31%), Positives = 78/154 (50%), Gaps = 7/154 (4%)

Query: 1455 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1514
            N  +  E+ ++L +Q  +Y   K+ ++Y   GQS  E  + +NE     + EFL  LG  
Sbjct: 591  NTPKVTEQLMKLDEQGLNYQ-QKVGIMYCKAGQSTEE-EMYNNESAGPAFEEFLQLLGER 648

Query: 1515 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1573
            + LK  +  +  L    D  G    +T     +IM   FH++T++P    +K +  +KRH
Sbjct: 649  VRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIM---FHVSTMLPYTPNNKQQLLRKRH 705

Query: 1574 LGNDFVSIVYNDSG-EDFKLGTIKGQFNFVHVIV 1606
            +GND V+IV+ + G + F    I+  F  V VIV
Sbjct: 706  IGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIV 739


>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
            sapiens]
          Length = 1781

 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 12/136 (8%)

Query: 1476 HKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV--- 1532
            HK+ +LY   GQS+ E  + +NE     + EFL+ +G  + LK       Y   LDV   
Sbjct: 623  HKVGILYCKAGQSSEE-EMYNNEEAGPAFEEFLSLIGEKVCLKGFTK---YAAQLDVKTD 678

Query: 1533 -CGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGE-DF 1590
              G    +T     +IM   FH++TL+P    ++ +  +KRH+GND V+I++ + G   F
Sbjct: 679  STGTHSLYTMYQDYEIM---FHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPF 735

Query: 1591 KLGTIKGQFNFVHVIV 1606
                I+  F  V +IV
Sbjct: 736  TPKNIRSHFQHVFIIV 751


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score = 42.4 bits (98), Expect = 0.004
 Identities = 52/229 (22%), Positives = 86/229 (37%), Gaps = 35/229 (15%)

Query: 1046 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQF 1105
            S P SSS+P        ++        G +   G R R++  S      V    +P    
Sbjct: 236  SSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETS------VAPFALPTVSL 289

Query: 1106 LGSATS--PGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVP---------LLTQGWAEIL 1154
            L + T   P P  A + +    + G R P+    +   ++P          L      IL
Sbjct: 290  LPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPIL 349

Query: 1155 VRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE---HRDTALYKSLSV 1211
            +  P+G+ + L+++          +  +P    + +LM  ER      H   +  +S  +
Sbjct: 350  LLDPSGSHAPLLTVPG--------LGPLPFH-FAQSLMTTERLSGSGLHWPLSRTRSEPL 400

Query: 1212 PAASTAKPPPLPRS------NTDSAVVMEEGSPGEVPVLVEPPGLEDVE 1254
            P ++TA PPP P         T   V+     P E P L + P  ED+E
Sbjct: 401  PPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLE 449


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 67/283 (23%), Positives = 98/283 (34%), Gaps = 27/283 (9%)

Query: 1106 LGSATSPGPRTAPAAKPEKASAGT-RVPVQEKTNLAAYVPLLTQGWAEILVRRPT--GNT 1162
            + S  S  P   P + P   S+ T   PV          PL    W+ +    P     T
Sbjct: 846  ISSQVSSNPSPHPTSSPLPFSSSTPEFPV----------PLSQCPWSSLPTTSPPTFSPT 895

Query: 1163 SWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPL 1222
               ++L +P  P     ++ P    +  L  A  F     T     LS      ++ PP 
Sbjct: 896  CSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPA 955

Query: 1223 PRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHA 1282
            P S   S  +    +PG            + EA+    R     +R + +S + +     
Sbjct: 956  PPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGK----- 1010

Query: 1283 EELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGR 1342
             +LVGR     +V SS+   P+  L  QP+ P    S  P    L     D  D A  G 
Sbjct: 1011 PQLVGR----FQVTSSK--EPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGP 1064

Query: 1343 LSPEVKARSQSGTLDGESAAWSASGEDSRGQPEG--PLPSSSP 1383
             + E  A S     +G  A     G+D +    G  P P S P
Sbjct: 1065 ETREALAESDRAA-EGLGAGVEEEGDDGKEPQVGGSPQPLSHP 1106


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score = 40.8 bits (94), Expect = 0.012
 Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 8/127 (6%)

Query: 1299 EGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPE-VKARSQSGTLD 1357
            +G R  + L      P  +  S   +Q +  + G+ G+K D G   P+ +     S   D
Sbjct: 1488 DGPRGEIGLPGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRD 1547

Query: 1358 GESAAWSASGED-SRGQPEGPLPSSSPRSP------SGLRPRGYTISDSAPSRRGKRVER 1410
            G        G+D S G P  P P   P +P        + P+G       P  +G+R ER
Sbjct: 1548 GSPGQRGLPGKDGSSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGER 1607

Query: 1411 DALKSRA 1417
              L+S+A
Sbjct: 1608 GDLQSQA 1614


>gi|145199237 transcription elongation factor B polypeptide 3 binding
            protein 1 [Homo sapiens]
          Length = 1221

 Score = 40.8 bits (94), Expect = 0.012
 Identities = 93/419 (22%), Positives = 143/419 (34%), Gaps = 68/419 (16%)

Query: 1053 SPGVHVRQTKEA-----PAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALD-VPASQFL 1106
            SPG H   + +A     P    ++ G + S  + DR +   GG G   GAL+ VP +   
Sbjct: 152  SPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGG---GALEYVPKA--- 205

Query: 1107 GSATSPGPRTAPAAKPEKASAGTRVPVQEK----TNLAAYVPLLTQGWAEILVRRPTGNT 1162
               + P   + P    +     +R P   +    +N +A          E   +RP G+ 
Sbjct: 206  --VSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSR 263

Query: 1163 SWLMSLENPLSPFSSDINNMPLQELSNALMAAE-RFKEHRDTALYKSLSVPAASTAKPPP 1221
                    P +P          ++L +   + + RF +  D A     + P  ++     
Sbjct: 264  G-----SEPYTPAP--------KKLCDPFGSCDARFSDSEDEAATVPGNEPTTAST---- 306

Query: 1222 LPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLH 1281
             P++  D           E+    +PP  E +EA  G  R T   +    V   +     
Sbjct: 307  -PKARADP----------EIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAK 355

Query: 1282 AEELVGRGIPIERVVSSEGG-----RPSVDLSFQPSQPLSKSSSSPELQTLQDILGDP-- 1334
                     P +   S +GG     +P    +  P  P  K  +  + +T     G P  
Sbjct: 356  PAS------PAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVE 409

Query: 1335 ---GDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRP 1391
                DK      SP  KA    GT    S+A   +    +G+P+ P    SP S    RP
Sbjct: 410  KPRADKKGPQASSPRRKAERPEGTKKKPSSATPVA-TSGKGRPDRPARRPSPTSGDS-RP 467

Query: 1392 ---RGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDES 1447
               RG       P R+  +     L  R   S  E      P      L H+  FGDES
Sbjct: 468  AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES 526


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 40.0 bits (92), Expect = 0.020
 Identities = 89/356 (25%), Positives = 130/356 (36%), Gaps = 55/356 (15%)

Query: 1097 ALDVPASQFLGSATSPGPRTAPA-AKPEKASAGTRVPVQEKT-NLAAYVPLLTQGWAEIL 1154
            +LD PAS F  S+  P P   P+ A+P  A  G+     ++   LA   P  T+    + 
Sbjct: 2160 SLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLE 2219

Query: 1155 VRRPTGNTSWLMSLENPLSPFSSDINNMP------LQELSNA-------LMAAERFKEHR 1201
            V +     S L  L +P SP +  ++N+P      L E S++          AERF    
Sbjct: 2220 VTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFSPSL 2279

Query: 1202 DTALYKSLSV-----PAAST----AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLED 1252
            + A  +S  +     PAA +        P P ++ D A+      PG++   + P  LE 
Sbjct: 2280 EAAEQESGELDPGMEPAAHSLWDLTPLSPAPPASLDLALAPAPSLPGDMGDGILPCHLEC 2339

Query: 1253 VEAALGMDRRTDAYSRSSSVSSQEEKS--------LHAEELVGRGIPI-ERVVSSEGGRP 1303
             EAA          S   + +   E S          AE       P  ER    EG   
Sbjct: 2340 SEAATEKPSPFQVPSEDCAANGPTETSPNPPGPAPAKAENEEAAACPAWERGAWPEGAER 2399

Query: 1304 S--VDLSFQPSQPL--------SKSSSSPELQT-LQDILGDPGDKADVGRLSPEVKARSQ 1352
            S   D    P QP+          SS+SPE++   Q    +P  +   G LSP       
Sbjct: 2400 SSRPDTLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATEP--RPHRGELSPSFLNPPL 2457

Query: 1353 SGTLDGESAAWS---ASGEDSR------GQPEGPLPSSSPRSPSGLRPRGYTISDS 1399
              ++D    +       G   R      G   GP P +    P+     G + SDS
Sbjct: 2458 PPSIDDRDLSTEEVRLVGRGGRRRVGGPGTTGGPCPVTDETPPTSASDSGSSQSDS 2513


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 40.0 bits (92), Expect = 0.020
 Identities = 130/575 (22%), Positives = 189/575 (32%), Gaps = 94/575 (16%)

Query: 903  PFRKD-FVPFITKGLRSNVLLSFDDT----PEKDSFRARSTSLNERPKRIQTSLTSASLG 957
            P +KD F PF  +  R    L F DT    P + S    S    E+   + TS     L 
Sbjct: 1181 PRQKDKFSPFPVQD-RPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELM 1239

Query: 958  SADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPK--RSPVGEFLLAGGRTKT 1015
               E S   A   L +L  EL E           SNF + P+    P     L   +++ 
Sbjct: 1240 EVVEKSEEPAGQILSHLSSELKEMST--------SNFESSPEVEERPAVSLTLDQSQSQA 1291

Query: 1016 WLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQ 1075
             L   ++ ++ +S G    S    +  EL + P   +S G  +      P       G +
Sbjct: 1292 SLEAVEVPSMASSWGGPHFSP---EHKELSNSPLRENSFGSPLEFRNSGPL------GTE 1342

Query: 1076 VSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGT------ 1129
            ++ G    V+    G  L     D        S  S G  ++  +      AG       
Sbjct: 1343 MNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSI 1402

Query: 1130 ---------RVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDIN 1180
                     R P +E+++ A+  P +  G      RR    +S          P   D +
Sbjct: 1403 SSPVLDAVPRTPSRERSSSASS-PEMKDGLPRTPSRRSRSGSS----------PGLRDGS 1451

Query: 1181 NMPLQE-LSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVME----- 1234
              P +  LS +    +           +  S P        P PRS + S+  +      
Sbjct: 1452 GTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLT 1511

Query: 1235 --------EGSPGEVPVLVEPPGLEDVEAA---LGMDRRTDAYSRSSSVSSQEEKSLHAE 1283
                    E S  +  V   P G      +   L +        RS S SS + K+    
Sbjct: 1512 PQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRT 1571

Query: 1284 ELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDIL--------GDPG 1335
             L  R        S  G  P VD   + S   S+S SSPE++                P 
Sbjct: 1572 PLRQR--------SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPE 1623

Query: 1336 DKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYT 1395
             KA   R  P       S    G S   S+S E S   PE P  S + R  S   P   T
Sbjct: 1624 PKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESS---PEHPPKSRTARRGSRSSPEPKT 1680

Query: 1396 ISDSAPSRRGKRVE-------RDALKSRATASNAE 1423
             S + P RR  R         R + +SR+ +S+ E
Sbjct: 1681 KSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPE 1715



 Score = 38.5 bits (88), Expect = 0.058
 Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 28/208 (13%)

Query: 1233 MEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPI 1292
            M  G   EV   +  P L  +E    +D +  + +RSS  SS E   L  + +   G+  
Sbjct: 1343 MNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQS-TRSSGHSSSE---LSPDAVEKAGMSS 1398

Query: 1293 ERVVSSEGGRPSVD-LSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARS 1351
             + +SS    P +D +   PS+  S S+SSPE++      G P   +   R       R 
Sbjct: 1399 NQSISS----PVLDAVPRTPSRERSSSASSPEMKD-----GLPRTPSRRSRSGSSPGLRD 1449

Query: 1352 QSGTLDGESAAWSASG------EDSRGQPE---GPLPSSSPRSPSGLRPRGYTISDSAPS 1402
             SGT    S + S+ G        SRG+ E    P P + P++P   RPR  + S S+P 
Sbjct: 1450 GSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTP---RPR--SRSPSSPE 1504

Query: 1403 RRGKRVERDALKSRATASNAEKVPGINP 1430
               K +     +S + +S  +K     P
Sbjct: 1505 LNNKCLTPQRERSGSESSVDQKTVARTP 1532



 Score = 33.9 bits (76), Expect = 1.4
 Identities = 80/345 (23%), Positives = 120/345 (34%), Gaps = 48/345 (13%)

Query: 1109 ATSP----GPRTAPAAKPEKASAGTRVPVQEKTNL-------AAYVPLLTQGWAEILVRR 1157
            AT+P    G RTA A  P   ++    P     NL       +AY  +  +    +L R 
Sbjct: 2346 ATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRA 2405

Query: 1158 -----PTGNTSWLMSLENPLSPFSSDINNMPLQEL------------SNALMAAERFKEH 1200
                 P+  +   M+ E   SP SS +   P Q L             +A     R    
Sbjct: 2406 RSRTPPSAPSQSRMTSERAPSP-SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA 2464

Query: 1201 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSP----GEVPVLV---EPPGLEDV 1253
            + T +  S S+ + + A        +     V   G P    GE P      +P  L  +
Sbjct: 2465 QTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL 2524

Query: 1254 EAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ 1313
            + A   +RR+ + S SSS SS    S  +          +   SS   +P V L   PS 
Sbjct: 2525 QPA--KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582

Query: 1314 PLSKSSSSPELQTLQDILGDPGDK--ADVGRLSPEVKARSQSGTLDGESAAWSASGEDSR 1371
              +   +  E        G P +   A   R S    + S S +    S++ S+S   S 
Sbjct: 2583 TPAPKEAVRE--------GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2634

Query: 1372 GQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR 1416
                    SSS  SPS  +P    +   A  ++    ER +   R
Sbjct: 2635 SSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPR 2679



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 108/468 (23%), Positives = 160/468 (34%), Gaps = 50/468 (10%)

Query: 1047 GPESSSSPGVHVRQTKEAPAKLESQAGQQV-SRGARDRVRSMSGGHG-----LRVGALDV 1100
            G   S +P    R     PA+   ++  +  +R  R R R+   G       +R G    
Sbjct: 656  GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHS 715

Query: 1101 PASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1160
               Q  G + S   R   +   ++ S     P  +K+ +++             +  P  
Sbjct: 716  RTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSR--------RSRSLSSPRS 767

Query: 1161 NTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVP--AASTAK 1218
                 +SL   LS  S      P Q+         R +        KS + P  + S++ 
Sbjct: 768  KAKSRLSLRRSLSGSSP----CPKQKSQTP---PRRSRSGSSQPKAKSRTPPRRSRSSSS 820

Query: 1219 PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSS--QE 1276
            PPP  +S T S       SP        PP    + +    ++      RS   SS   E
Sbjct: 821  PPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPE 880

Query: 1277 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1336
             KS         G    RV SS   R S   S  P QP  K+  SP  Q        P  
Sbjct: 881  LKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSP-QPKVKAIISPR-QRSHSGSSSPSP 938

Query: 1337 KADVGRLSPEVKARSQSGTLDGES---AAWSASGE---DSRGQPEGPLPSSSPRSPSGLR 1390
                 R +P  ++RS S   + ES     +S SG    D++ +PE P P  S        
Sbjct: 939  SRVTSRTTPR-RSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETP-PRQSHSGSISPY 996

Query: 1391 PRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKP 1450
            P+    +   PS  G +      KS+   S  +  PG            S   G +S+ P
Sbjct: 997  PKVKAQTPPGPSLSGSKSPCPQEKSK--DSLVQSCPG----------SLSLCAGVKSSTP 1044

Query: 1451 ILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNE 1498
               P ES     S+QL  Q  +   H+         QS+SE   L ++
Sbjct: 1045 ---PGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSK 1089


>gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens]
          Length = 1268

 Score = 39.7 bits (91), Expect = 0.026
 Identities = 61/244 (25%), Positives = 88/244 (36%), Gaps = 19/244 (7%)

Query: 952  TSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGG 1011
            +S  L S  +N +     SL   +   T T  D ++  V  N    PK SPV   +L+G 
Sbjct: 263  SSPGLPSTQDNLIRNHTGSLAVANNNPTITVADSLSCPVMQNVQP-PKSSPVVSTVLSGS 321

Query: 1012 R----TKTWLVGNKLVTVTTSVGTGTRSLL--GLDSGELQSGPESSSSPGVHVRQTKEAP 1065
                 T+T    N  V   TSV   +  L   G+  GE  +   SS+   +      E  
Sbjct: 322  SGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGVQYGEYVNNQASSAPTPLSSTSDDEEE 381

Query: 1066 AKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL-DVPASQFLGSATSPGPRTAPAAKPEK 1124
             + + +AG   S          +    L  G+  D+ +S     A  P P   PA+ P  
Sbjct: 382  EEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAPAP 441

Query: 1125 ASAGTRVPVQEKTNLAAY---VPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINN 1181
            ASA   V  Q       +    P L  G+           T+ L+S   P +P  S    
Sbjct: 442  ASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNA--------TAPLISGVQPSNPVYSGFQQ 493

Query: 1182 MPLQ 1185
             P Q
Sbjct: 494  YPQQ 497


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 39.3 bits (90), Expect = 0.034
 Identities = 80/344 (23%), Positives = 118/344 (34%), Gaps = 55/344 (15%)

Query: 1101 PASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1160
            PA      AT P P+ A AA+ E  + G R P +E               AE+LV+    
Sbjct: 2424 PAPLITMPATRPKPKKARAAE-ESGAKGPRRPGEE---------------AELLVK---- 2463

Query: 1161 NTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPP 1220
                 +  E   SP S       L          +  K       Y     PAA +++P 
Sbjct: 2464 -----LDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYP----PAAGSSEPK 2514

Query: 1221 -PLPRSNTDSAVVMEEG------------SPGEVPVLVEPPGLEDVEAALGMDRRTDAYS 1267
             P P++ TD  +  E G            SP +     E  G E+ E++      + + S
Sbjct: 2515 APWPKA-TDGDLAQEPGPGLTFEDSGNPKSPDKAQA--EQDGAEESESSSSSSSGSSSSS 2571

Query: 1268 RSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTL 1327
             SSS S  E +     +  G G          GGR     S + + P S SSSS    + 
Sbjct: 2572 SSSSSSGSETEGEEEGDKNGDG------GCGTGGRNCSAASSRAASPASSSSSSSSSSSS 2625

Query: 1328 QDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPS 1387
                      +     S    + S S +    S++ S+S   S         S S    +
Sbjct: 2626 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEA 2685

Query: 1388 GLRPRGYTISDSAPSRRGKRVERDALKSRATA-SNAEKVPGINP 1430
               P   T   SA +    +  + A K+R +A S  +K P   P
Sbjct: 2686 APAP---TAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQP 2726


>gi|223718207 ets variant gene 3 isoform 1 [Homo sapiens]
          Length = 512

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 87/357 (24%), Positives = 123/357 (34%), Gaps = 73/357 (20%)

Query: 1046 SGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMS----GGHGLRVGALDVP 1101
            SG ESS+         K   ++LE  +     RG  D V S +    GG G +    D+ 
Sbjct: 177  SGQESSNGT-----DRKTELSELEDGSAADWRRGV-DPVSSRNAIGGGGIGHQKRKPDIM 230

Query: 1102 ASQFLGSATSPGPRTAPAAKPEKASAGT-RVPVQEKTNLAAYVPLLTQGWAEILVRRPTG 1160
               F      P P +  A  P     G   VP+    +L                     
Sbjct: 231  LPLFARPGMYPDPHSPFAVSPIPGRGGVLNVPISPALSLTP------------------- 271

Query: 1161 NTSWLMSLENPLSPF-SSDINNMPLQELSNAL--MAAERFKEH---RDTALYKSLSVPAA 1214
             T +  S    LSPF SS   +   +E+ + L   A   F  H   R    Y  L VP  
Sbjct: 272  -TIFSYSPSPGLSPFTSSSCFSFNPEEMKHYLHSQACSVFNYHLSPRTFPRYPGLMVPPL 330

Query: 1215 STA-------------KPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDR 1261
                            +PPP+ R N +     EE +P   P +   P    VE A   D 
Sbjct: 331  QCQMHPEESTQFSIKLQPPPVGRKNRERVESSEESAPVTTPTMASIPPRIKVEPASEKD- 389

Query: 1262 RTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGG----RPSVDLSFQPSQPLSK 1317
                    S   S  EK  H +E    G    R +  E G    RP+      PS P+S 
Sbjct: 390  ------PESLRQSAREKEEHTQE---EGTVPSRTIEEEKGTIFARPAAP-PIWPSVPIST 439

Query: 1318 SSSSPELQTLQDILGDPG------DKADVGRLSPEVKARSQSGTLDGESAAWSASGE 1368
             S  P L+  +D    PG      +K +   + P+++ + +    D E+   S SG+
Sbjct: 440  PSGEP-LEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRWND-DPEARELSKSGK 494


>gi|33620755 YEATS domain containing 2 [Homo sapiens]
          Length = 1422

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 42/170 (24%), Positives = 68/170 (40%), Gaps = 22/170 (12%)

Query: 1174 PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVM 1233
            P +S    +P  ++ N     + F+    T   K +S    ST  P PLPR+ T + V +
Sbjct: 429  PIASSCKIVPQSQVPNPESPGKSFQPI--TMSCKIVSGSPISTPSPSPLPRTPTSTPVHV 486

Query: 1234 EEGSPGEV-----PVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGR 1288
            ++G+ G V      ++ + PG             T+  S +S VS             G 
Sbjct: 487  KQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQ------------GT 534

Query: 1289 GIPIERVVSSEGGRPSV---DLSFQPSQPLSKSSSSPELQTLQDILGDPG 1335
            G P+ ++  S     +V   D  F    PL    S P++Q+ + I G  G
Sbjct: 535  GSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLG 584


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 75/340 (22%), Positives = 115/340 (33%), Gaps = 31/340 (9%)

Query: 1107 GSATSPGPR---TAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTS 1163
            G  T+P  +   T PAA P         P   K   A   P        ++   P    +
Sbjct: 1358 GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPA 1417

Query: 1164 WLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLP 1223
              ++ E   +P   D+    +  +S  L  A      +      S        A  PP P
Sbjct: 1418 TPVTREGAATPSKGDLTPPAVTPVS--LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSP 1475

Query: 1224 RSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEA----------ALGMDRRTDAYSRSSSVS 1273
            +       V    SP + P    P G   + A          A    RR      ++ +S
Sbjct: 1476 KEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLS 1535

Query: 1274 SQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQ-PSQPLSKSSSSPELQTLQDILG 1332
             +   +L  +E +   IP    V S    P++    + P+ P SK +SSP   T     G
Sbjct: 1536 KKTPATLAPKEAL---IPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKG 1592

Query: 1333 DPGDK---ADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGP--LPSS---SPR 1384
             P  K         SP  K       +   S     +    +G P  P   PSS   SP 
Sbjct: 1593 APSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652

Query: 1385 SPSGLRPR-GYTI---SDSAPSRRGKRVERDALKSRATAS 1420
            SP+ +  + G T+   S   P+++G    ++ L + A  S
Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPES 1692



 Score = 32.0 bits (71), Expect = 5.4
 Identities = 71/349 (20%), Positives = 126/349 (36%), Gaps = 36/349 (10%)

Query: 1045 QSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQ 1104
            + GP + SS G         P+  E  A +QV+  +  +    +      +GA  +PA  
Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP---MGAPTLPA-- 1507

Query: 1105 FLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSW 1164
             + S+    P T  + +   A   T +  +    LA    L+      + V  P    + 
Sbjct: 1508 VIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPA---MTVPSPKKTPAI 1564

Query: 1165 LMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPL-- 1222
                E P +P S + ++ P    S    A       ++  +  +++ P+   A  PP   
Sbjct: 1565 PTPKEAPATPSSKEASSPPAVTPSTYKGAPSP----KELLIPPAVTSPSPKEAPTPPAVT 1620

Query: 1223 -PRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLH 1281
             P      A    +G+P   PV   P  L+D   +           +  +   Q  K L 
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVT--PSSLKDSPTS-----PASVTCKMGATVPQASKGLP 1673

Query: 1282 AEELVGRGIPIERVVSSEGGRPSVDLSFQPSQ--PLSKSSSSPELQTLQDILGDPGDKAD 1339
            A+    +G    + V       S  +   P++  P +K SS+       D     G K  
Sbjct: 1674 AK----KGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGP 1729

Query: 1340 VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPL--PSSSPRSP 1386
            +  ++P      Q      + ++ +A G+D+   P+GPL  P S   +P
Sbjct: 1730 LSTVAPAPLLPVQ------KDSSKTAKGKDASHSPKGPLAPPESKASTP 1772


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 84/376 (22%), Positives = 129/376 (34%), Gaps = 45/376 (11%)

Query: 1047 GPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFL 1106
            G    S      R+  E      S+ G  VS  A +    MSGG     GA         
Sbjct: 4    GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNP--EMSGG-----GAPAEETKGTA 56

Query: 1107 GSATSPGPRTAPAAKPEKASA--GTRVPVQEKTNLAAYVPLLTQGWA------EILVRRP 1158
            G A + GP T  + K EKA A  G    +Q + N    V + +Q  A      E  +++ 
Sbjct: 57   GKAINEGPPTE-SGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKE 115

Query: 1159 TGNTSWLMSLENPLSPFSSDINNMPLQ-ELSNALMAAERFK-EHRDTALYKSLSVPAAST 1216
             G           ++    +  + P + E   + +A+E+ K E ++          A   
Sbjct: 116  DGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDR 175

Query: 1217 AKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE 1276
             KP P      + A    +   G+       P           ++ TD  +++ S  +  
Sbjct: 176  DKPEPKATVEEEDAKTASQEETGQRKECSTEP----------KEKATDEEAKAESQKAVV 225

Query: 1277 EKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGD 1336
            E    AE     G    +  +  G +   D   +          SP  +  QD+  +P  
Sbjct: 226  EDEAKAEPKEPDG----KEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281

Query: 1337 KADVGRLSPEVKARSQSG-----TLDGESAAWSASGEDSRGQPE---GPLPSSSPRSPSG 1388
             A V   SPE    S +G     + DG      ASG+ S    E     +P S P SPS 
Sbjct: 282  GAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSS 341

Query: 1389 LRPRGYTISDSAPSRR 1404
               +     + AP RR
Sbjct: 342  GEKK-----EKAPERR 352


>gi|110611914 progesterone receptor [Homo sapiens]
          Length = 933

 Score = 38.1 bits (87), Expect = 0.075
 Identities = 70/298 (23%), Positives = 107/298 (35%), Gaps = 44/298 (14%)

Query: 1106 LGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWL 1165
            LG A + G   A A  P  A+ G  +  +E +  +A    L +  A +   R        
Sbjct: 244  LGGAAAGGG--AAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGR-------- 293

Query: 1166 MSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRS 1225
                +PL+    D  ++P+  L++AL+AA R ++  +   Y   +  A++ A P   P +
Sbjct: 294  ----SPLATTVMDFIHVPILPLNHALLAA-RTRQLLEDESYDGGAGAASAFAPPRSSPCA 348

Query: 1226 NTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEEL 1285
            ++    V      G+ P    PP  E          + DAY   S       K    EE 
Sbjct: 349  SSTPVAV------GDFPDCAYPPDAEP---------KDDAYPLYSDFQPPALKIKEEEEG 393

Query: 1286 VGRGIPIERVVSSEGGRPSV--DLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA-DVGR 1342
                    R     G  P+   D    P  PL   ++             PG+ A     
Sbjct: 394  AEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSR----------PGEAAVTAAP 443

Query: 1343 LSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSA 1400
             S  V + S SG+   E   + A G   +  P  P P  +P +   L PR    S SA
Sbjct: 444  ASASVSSASSSGSTL-ECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSA 500


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,346,718
Number of Sequences: 37866
Number of extensions: 3397826
Number of successful extensions: 17362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 206
Number of HSP's that attempted gapping in prelim test: 16586
Number of HSP's gapped (non-prelim): 1122
length of query: 1740
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1624
effective length of database: 13,855,062
effective search space: 22500620688
effective search space used: 22500620688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.