Search of human proteins with 23308553

Search of human proteins with 23308553

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23308553 spermatogenesis associated 13 [Homo sapiens]
         (652 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23308553 spermatogenesis associated 13 [Homo sapiens]             1336   0.0  
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   694   0.0  
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   657   0.0  
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]             641   0.0  
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          208   1e-53
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          208   1e-53
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   202   6e-52
gi|71274148 pleckstrin homology domain containing, family G (wit...   128   2e-29
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom...   124   4e-28
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom...   124   4e-28
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo...   124   4e-28
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom...   122   8e-28
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ...   122   8e-28
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   122   1e-27
gi|163644325 MCF.2 cell line derived transforming sequence-like ...   114   3e-25
gi|163644323 MCF.2 cell line derived transforming sequence-like ...   114   3e-25
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo...   112   8e-25
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   109   9e-24
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   109   9e-24
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   105   1e-22
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...   104   2e-22
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...   103   6e-22
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               102   1e-21
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...   100   5e-21
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    99   9e-21
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    99   9e-21
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    99   9e-21
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    99   1e-20
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ...    98   3e-20
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     97   4e-20

>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 1336 bits (3458), Expect = 0.0
 Identities = 652/652 (100%), Positives = 652/652 (100%)

Query: 1   MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQV 60
           MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQV
Sbjct: 1   MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQV 60

Query: 61  PPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSY 120
           PPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSY
Sbjct: 61  PPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSY 120

Query: 121 EDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEAS 180
           EDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEAS
Sbjct: 121 EDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEAS 180

Query: 181 NKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQM 240
           NKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQM
Sbjct: 181 NKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQM 240

Query: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300
           RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL
Sbjct: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300

Query: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEA 360
           KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEA
Sbjct: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEA 360

Query: 361 CRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL 420
           CRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL
Sbjct: 361 CRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL 420

Query: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD 480
           INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD
Sbjct: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD 480

Query: 481 HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYL 540
           HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYL
Sbjct: 481 HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYL 540

Query: 541 FCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCP 600
           FCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCP
Sbjct: 541 FCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCP 600

Query: 601 VAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK 652
           VAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
Sbjct: 601 VAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK 652


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score =  694 bits (1791), Expect = 0.0
 Identities = 353/586 (60%), Positives = 435/586 (74%), Gaps = 17/586 (2%)

Query: 71  RPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRY 130
           R    SQS P GL+ +G       + +  DG  + +   D+ GSEED  Y+DL  +S  Y
Sbjct: 118 RSHPLSQSAPTGLNHMGWPEHTPGTAMP-DGALDTAVCADEVGSEEDL-YDDLHSSSHHY 175

Query: 131 LQPGG--EQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGR 188
             PGG  EQLAINELISDG+VVCAEALWDHVTMDDQELGFKAGDVI+V++A+N++WWWGR
Sbjct: 176 SHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGR 235

Query: 189 SEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREI 248
             D E WFPASFVRLRVNQ+E +++ +        E+          +K QMRTNVI EI
Sbjct: 236 VADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQ---SSKDQMRTNVINEI 292

Query: 249 MDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYN 308
           + TER YIKHLRDICEGY+RQCRK   MF+  QL TIFGNIEDIY+ Q+ F+K LE+++N
Sbjct: 293 LSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFN 352

Query: 309 KEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMI 368
           +E PHLSE+G+CFL++Q  F IYSEYCNNHP AC+EL+ L K  KY +FFEACRLLQ+MI
Sbjct: 353 RERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI 412

Query: 369 DIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKL 428
           DI++DGFLLTPVQKICKYPLQLAELLKYT  +H D+ +++AA  AMKNVA LINERKR+L
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472

Query: 429 ESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITK-QGKSQQRTFFLFDHQLVSCK 487
           E+IDKIA+WQ SI  WEG D+L RSSELI+SGELT++T+ Q KSQQR FFLFDHQL+ CK
Sbjct: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532

Query: 488 KDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQE 547
           KDLLRRD+LYYKGRLDMD +E+VDL DG+D+D ++S+KNAF+L    T + +L C +K E
Sbjct: 533 KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592

Query: 548 DKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAG-HGKSKGYNRCPVAPPHQ 606
            K RWL+A A ER +VQ D+E G  I+E Q+K AMLNA K    GK K   R        
Sbjct: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGR-------- 644

Query: 607 GLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK 652
             +   Q+H  +P++ PQQQV  LAEP+RK S FWH+ +RL PFRK
Sbjct: 645 PCYLTRQKHPALPSNRPQQQVLVLAEPRRKPSTFWHSISRLAPFRK 690


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score =  657 bits (1694), Expect = 0.0
 Identities = 337/560 (60%), Positives = 413/560 (73%), Gaps = 13/560 (2%)

Query: 71  RPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRY 130
           R    SQS P GL+ +G       + +  DG  + +   D+ GSEED  Y+DL  +S  Y
Sbjct: 118 RSHPLSQSAPTGLNHMGWPEHTPGTAMP-DGALDTAVCADEVGSEEDL-YDDLHSSSHHY 175

Query: 131 LQPGG--EQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGR 188
             PGG  EQLAINELISDG+VVCAEALWDHVTMDDQELGFKAGDVI+V++A+N++WWWGR
Sbjct: 176 SHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGR 235

Query: 189 SEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREI 248
             D E WFPASFVRLRVNQ+E +++ +        E+          +K QMRTNVI EI
Sbjct: 236 VADGEGWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQ---SSKDQMRTNVINEI 292

Query: 249 MDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYN 308
           + TER YIKHLRDICEGY+RQCRK   MF+  QL TIFGNIEDIY+ Q+ F+K LE+++N
Sbjct: 293 LSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFN 352

Query: 309 KEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMI 368
           +E PHLSE+G+CFL++Q  F IYSEYCNNHP AC+EL+ L K  KY +FFEACRLLQ+MI
Sbjct: 353 RERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMI 412

Query: 369 DIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKL 428
           DI++DGFLLTPVQKICKYPLQLAELLKYT  +H D+ +++AA  AMKNVA LINERKR+L
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472

Query: 429 ESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITK-QGKSQQRTFFLFDHQLVSCK 487
           E+IDKIA+WQ SI  WEG D+L RSSELI+SGELT++T+ Q KSQQR FFLFDHQL+ CK
Sbjct: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532

Query: 488 KDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQE 547
           KDLLRRD+LYYKGRLDMD +E+VDL DG+D+D ++S+KNAF+L    T + +L C +K E
Sbjct: 533 KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592

Query: 548 DKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAG-HGKSKGYNRCPVAPPHQ 606
            K RWL+A A ER +VQ D+E G  I+E Q+K AMLNA K    GK KG       P   
Sbjct: 593 QKQRWLKAFAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKGRRTAAPPPRLP 652

Query: 607 GLHPIHQRHITMPTSVPQQQ 626
           G +P       +P S PQ Q
Sbjct: 653 GPYPAD----IIPFSEPQSQ 668


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score =  641 bits (1654), Expect = 0.0
 Identities = 318/520 (61%), Positives = 395/520 (75%), Gaps = 17/520 (3%)

Query: 143 LISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202
           LI+  ++V AEA+WDHVTM ++EL FKAGDVI+VL+ASNKDWWWG+ +D+E WFPASFVR
Sbjct: 4   LITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVR 63

Query: 203 LRVNQEELSENSSSTPSEEQDEEASQSRHRHC-----ENKQQMRTNVIREIMDTERVYIK 257
           L VNQE+  E     PS+ Q+     +    C     +N+ QMR NVI EIM TER YIK
Sbjct: 64  LWVNQEDEVEEG---PSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK 120

Query: 258 HLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEI 317
           HL+DICEGY++QCRK   MF+  QL  IFGNIEDIY+FQ  F++DLEKQYN ++PHLSEI
Sbjct: 121 HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI 180

Query: 318 GSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLL 377
           G CFL++Q+GF IYSEYCNNH  AC+EL+ LMK  +Y+HFFEACRLLQQMIDIAIDGFLL
Sbjct: 181 GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL 240

Query: 378 TPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARW 437
           TPVQKICKYPLQLAELLKYT Q+H DY  + AA   M+NV   INERKR+LE+IDKIA+W
Sbjct: 241 TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW 300

Query: 438 QVSIVGWEGLDILDRSSELIHSGELTKITK-QGKSQQRTFFLFDHQLVSCKKDLLRRDML 496
           Q S++ WEG DILDRSSELI++GE+  I +  G++QQR FFLFDHQ+V CKKDL+RRD+L
Sbjct: 301 QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL 360

Query: 497 YYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQAC 556
           YYKGR+DMD+ E+VD+ DGRD D N+S+KNAFKL ++ T+E++LF AKK E+K RWL+A 
Sbjct: 361 YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF 420

Query: 557 ADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRC----PVAPPHQGLHPIH 612
            +ER+ VQED+++G EISENQK+ A +  +K    K KG N      P  PP Q   P++
Sbjct: 421 REERKMVQEDEKIGFEISENQKRQAAMTVRKV--PKQKGVNSARSVPPSYPPPQ--DPLN 476

Query: 613 QRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK 652
                +P  + Q QVF   EPKR  S FW  F+RLTPF+K
Sbjct: 477 HGQYLVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKK 516


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  208 bits (529), Expect = 1e-53
 Identities = 135/387 (34%), Positives = 210/387 (54%), Gaps = 28/387 (7%)

Query: 219 SEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR---QCR--KH 273
           SE+   ++     +  E + ++R  V+ E+  TER Y+  L  +   ++    QC   K 
Sbjct: 2   SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV 61

Query: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSE 333
               T   +  +F NIEDI    ++FLK +E+  + E     E+G+CFL  ++ F IY E
Sbjct: 62  DKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDE 121

Query: 334 YCNNHPGACLELANLMKQGKYRHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLA 391
           YC+NH  A   L  L K    R F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L 
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181

Query: 392 ELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILD 451
           ELLK T ++H DY+ +  A +AMK V   INE KR++E ++ +  WQ  I GWEG +I D
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITD 241

Query: 452 RSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLR---------RDMLYYKGRL 502
             +E++  G L KI+  G  Q+R FFLFD+ LV CK+   R              ++GR+
Sbjct: 242 TCTEMLMCGVLLKIS-SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300

Query: 503 DMDEMELVDLGDGRDKDCNLS---VKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADE 559
           + + ME+ ++ DG   D + S   V N +K+ +   ++ ++  AK  E+K  W +A   E
Sbjct: 301 NTEVMEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359

Query: 560 RRRVQEDKEMGME------ISENQKKL 580
           R R ++  ++GME      ISE  +KL
Sbjct: 360 RER-RKGLKLGMEQDTWVMISEQGEKL 385


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  208 bits (529), Expect = 1e-53
 Identities = 135/387 (34%), Positives = 210/387 (54%), Gaps = 28/387 (7%)

Query: 219 SEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR---QCR--KH 273
           SE+   ++     +  E + ++R  V+ E+  TER Y+  L  +   ++    QC   K 
Sbjct: 2   SEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKV 61

Query: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSE 333
               T   +  +F NIEDI    ++FLK +E+  + E     E+G+CFL  ++ F IY E
Sbjct: 62  DKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDE 121

Query: 334 YCNNHPGACLELANLMKQGKYRHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLA 391
           YC+NH  A   L  L K    R F   C LL  ++  D+ ++G+L+TP+Q+ICKYPL L 
Sbjct: 122 YCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILK 181

Query: 392 ELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILD 451
           ELLK T ++H DY+ +  A +AMK V   INE KR++E ++ +  WQ  I GWEG +I D
Sbjct: 182 ELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITD 241

Query: 452 RSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLR---------RDMLYYKGRL 502
             +E++  G L KI+  G  Q+R FFLFD+ LV CK+   R              ++GR+
Sbjct: 242 TCTEMLMCGVLLKIS-SGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRI 300

Query: 503 DMDEMELVDLGDGRDKDCNLS---VKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADE 559
           + + ME+ ++ DG   D + S   V N +K+ +   ++ ++  AK  E+K  W +A   E
Sbjct: 301 NTEVMEVENVDDG-TADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKE 359

Query: 560 RRRVQEDKEMGME------ISENQKKL 580
           R R ++  ++GME      ISE  +KL
Sbjct: 360 RER-RKGLKLGMEQDTWVMISEQGEKL 385


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  202 bits (515), Expect = 6e-52
 Identities = 128/378 (33%), Positives = 208/378 (55%), Gaps = 31/378 (8%)

Query: 232 RHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-----FTVAQLATIF 286
           R  E + ++R  V+ EI+ TER Y+  LR +   ++ + R++         T   +  +F
Sbjct: 41  RESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLF 100

Query: 287 GNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELA 346
            NIEDI +  + FL  LE   + E     E+G+ FL+ ++ F +Y EYC+NH  A   L 
Sbjct: 101 SNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLV 160

Query: 347 NLMKQGKYRHFFEACRLL--QQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDY 404
            L K    R F  +C LL  ++  DI ++G+LL+P+Q+ICKYPL L EL K T  +H D+
Sbjct: 161 ELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDH 220

Query: 405 SNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTK 464
             +++A +AMK V   INE KR++E ++ + + Q  I GWEG ++ D  ++L+  G L K
Sbjct: 221 PAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLK 280

Query: 465 ITKQGKSQQRTFFLFDHQLVSCKK--------------DLLRRDMLYYKGRLDMDEMELV 510
           I+  G  Q+R FFLFD+ LV CK+                +   +  ++GR++ + ME+ 
Sbjct: 281 IS-AGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVE 339

Query: 511 DLGDG-RDKDCN-LSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKE 568
           ++ DG  D   N  +V N +K+ +   ++ ++  AK  E+K +WL A   ER + +E  +
Sbjct: 340 NVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQ-RESLK 398

Query: 569 MGME------ISENQKKL 580
           +GME      I+E  +KL
Sbjct: 399 LGMERDAYVMIAEKGEKL 416


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  128 bits (321), Expect = 2e-29
 Identities = 89/272 (32%), Positives = 135/272 (49%), Gaps = 17/272 (6%)

Query: 244 VIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-FTVAQLATIFGNIEDIYKFQRKFLKD 302
           V++EI++TER Y++ L+ I E Y+   R  T +     + + +FGNI+DIY F  + L+D
Sbjct: 117 VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQD 176

Query: 303 LEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACR 362
           LE   N        I  CF+   E F IY++YC N+P +   L   M+      FF   R
Sbjct: 177 LENCENDPVA----IAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFF---R 229

Query: 363 LLQQMI--DIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL 420
             Q+ +   + +  +LL PVQ+I KY L L E+  +  ++   Y  +  A + M+ VA  
Sbjct: 230 ERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWH 289

Query: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD 480
           IN+ KRK E   ++   Q  +  W+G D L    EL+  G       Q    +RT FLFD
Sbjct: 290 INDMKRKHEHAVRLQEIQSLLTNWKGPD-LTSYGELVLEG---TFRIQRAKNERTLFLFD 345

Query: 481 HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDL 512
             L+  KK   R D   YK  +    + LV++
Sbjct: 346 KLLLITKK---RDDTFTYKAHILCGNLMLVEV 374


>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
           sapiens]
          Length = 753

 Score =  124 bits (310), Expect = 4e-28
 Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)

Query: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
           G+  +++   +  N +   A ++    ++ EL F  GDVI V       WW G    +  
Sbjct: 122 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 181

Query: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
           WFP+++VR ++ +++ +S  S +  S  +  + +        NK      V++ I++TE 
Sbjct: 182 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 234

Query: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
            Y K L+ +   Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E  
Sbjct: 235 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 293

Query: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
              +G CFL        +Y  YC NHP A   L    ++     F E        I +  
Sbjct: 294 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 350

Query: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
            G L  P  ++ KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +
Sbjct: 351 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 409

Query: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
             +     +I  WEG DI    +    S  L +     +  +R   LF + L+       
Sbjct: 410 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 465

Query: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
           R     Y+G+L    M +  L D  +       +NAF++     + + + C   Q+D   
Sbjct: 466 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 518

Query: 552 WLQ 554
           W++
Sbjct: 519 WVE 521


>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
           sapiens]
          Length = 803

 Score =  124 bits (310), Expect = 4e-28
 Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)

Query: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
           G+  +++   +  N +   A ++    ++ EL F  GDVI V       WW G    +  
Sbjct: 172 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 231

Query: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
           WFP+++VR ++ +++ +S  S +  S  +  + +        NK      V++ I++TE 
Sbjct: 232 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 284

Query: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
            Y K L+ +   Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E  
Sbjct: 285 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 343

Query: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
              +G CFL        +Y  YC NHP A   L    ++     F E        I +  
Sbjct: 344 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 400

Query: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
            G L  P  ++ KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +
Sbjct: 401 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 459

Query: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
             +     +I  WEG DI    +    S  L +     +  +R   LF + L+       
Sbjct: 460 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 515

Query: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
           R     Y+G+L    M +  L D  +       +NAF++     + + + C   Q+D   
Sbjct: 516 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 568

Query: 552 WLQ 554
           W++
Sbjct: 569 WVE 571


>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
           sapiens]
          Length = 782

 Score =  124 bits (310), Expect = 4e-28
 Identities = 104/423 (24%), Positives = 183/423 (43%), Gaps = 26/423 (6%)

Query: 135 GEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEA 194
           G+  +++   +  N +   A ++    ++ EL F  GDVI V       WW G    +  
Sbjct: 151 GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTG 210

Query: 195 WFPASFVR-LRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTER 253
           WFP+++VR ++ +++ +S  S +  S  +  + +        NK      V++ I++TE 
Sbjct: 211 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETEN 263

Query: 254 VYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPH 313
            Y K L+ +   Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E  
Sbjct: 264 EYSKELQTVLSTYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ 322

Query: 314 LSEIGSCFLQNQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAI 372
              +G CFL        +Y  YC NHP A   L    ++     F E        I +  
Sbjct: 323 -QRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLT 379

Query: 373 DGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESI 431
            G L  P  ++ KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +
Sbjct: 380 TG-LSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELEL 438

Query: 432 DKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLL 491
             +     +I  WEG DI    +    S  L +     +  +R   LF + L+       
Sbjct: 439 QILTE---AIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-P 494

Query: 492 RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKAR 551
           R     Y+G+L    M +  L D  +       +NAF++     + + + C   Q+D   
Sbjct: 495 RMSGFIYQGKLPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQE 547

Query: 552 WLQ 554
           W++
Sbjct: 548 WVE 550


>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  122 bits (307), Expect = 8e-28
 Identities = 103/413 (24%), Positives = 178/413 (43%), Gaps = 26/413 (6%)

Query: 145 SDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR-L 203
           +  N +   A ++    ++ EL F  GDVI V       WW G    +  WFP+++VR +
Sbjct: 4   NSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63

Query: 204 RVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDIC 263
           + +++ +S  S +  S  +  + +        NK      V++ I++TE  Y K L+ + 
Sbjct: 64  KASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETENEYSKELQTVL 116

Query: 264 EGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQ 323
             Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E     +G CFL 
Sbjct: 117 STYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLN 174

Query: 324 NQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQK 382
                  +Y  YC NHP A   L    ++     F E        I +   G L  P  +
Sbjct: 175 LMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLTTG-LSKPFMR 231

Query: 383 ICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSI 441
           + KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +  +     +I
Sbjct: 232 LDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTE---AI 288

Query: 442 VGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGR 501
             WEG DI    +    S  L +     +  +R   LF + L+       R     Y+G+
Sbjct: 289 RNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGK 347

Query: 502 LDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554
           L    M +  L D  +       +NAF++     + + + C   Q+D   W++
Sbjct: 348 LPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQEWVE 393


>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
           sapiens]
          Length = 646

 Score =  122 bits (307), Expect = 8e-28
 Identities = 103/413 (24%), Positives = 178/413 (43%), Gaps = 26/413 (6%)

Query: 145 SDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR-L 203
           +  N +   A ++    ++ EL F  GDVI V       WW G    +  WFP+++VR +
Sbjct: 4   NSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63

Query: 204 RVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDIC 263
           + +++ +S  S +  S  +  + +        NK      V++ I++TE  Y K L+ + 
Sbjct: 64  KASEKPVSPKSGTLKSPPKGFDTT------AINKSYYNV-VLQNILETENEYSKELQTVL 116

Query: 264 EGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQ 323
             Y+R  +  +   + A ++ + GN+E+I  FQ+  ++ LE+     E     +G CFL 
Sbjct: 117 STYLRPLQT-SEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ-QRVGGCFLN 174

Query: 324 NQEGF-AIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQK 382
                  +Y  YC NHP A   L    ++     F E        I +   G L  P  +
Sbjct: 175 LMPQMKTLYLTYCANHPSAVNVLTEHSEE--LGEFMETKGASSPGILVLTTG-LSKPFMR 231

Query: 383 ICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSI 441
           + KYP  L EL ++    H D  +I+ +  A KN++    E RKRK   +  +     +I
Sbjct: 232 LDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTE---AI 288

Query: 442 VGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGR 501
             WEG DI    +    S  L +     +  +R   LF + L+       R     Y+G+
Sbjct: 289 RNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSAS-PRMSGFIYQGK 347

Query: 502 LDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554
           L    M +  L D  +       +NAF++     + + + C   Q+D   W++
Sbjct: 348 LPTTGMTITKLEDSENH------RNAFEISGSMIERILVSC-NNQQDLQEWVE 393


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  122 bits (306), Expect = 1e-27
 Identities = 105/324 (32%), Positives = 149/324 (45%), Gaps = 40/324 (12%)

Query: 244 VIREIMDTERVYIKHLRDICEGYIRQCRKHTGM-FTVAQLATIFGNIEDIYKFQRKFLKD 302
           V REI++TER Y++ LR I E Y+        +  +V Q+ T+F NIEDIY+F  + L+D
Sbjct: 106 VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLED 165

Query: 303 LEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACR 362
           LE   +        I  CF+Q  E F IY+ YC N+P +   L  L        + +  R
Sbjct: 166 LENSSS-----AGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQE-R 219

Query: 363 LLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSN--IKAAYEAMKNVACL 420
             Q    + +  FLL PVQ+I KY L L EL K+  +  G      ++ A  +M  VA  
Sbjct: 220 QAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWY 279

Query: 421 INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQG---KSQQRTFF 477
           IN+ KRK E   ++   Q  + GW G + L    EL+  G        G   +  +R  F
Sbjct: 280 INDMKRKQEHAARLQEVQRRLGGWTGPE-LSAFGELVLEGAFRGGGGGGPRLRGGERLLF 338

Query: 478 LFDHQLVSCKKDLLRRDMLY-YKGRLDMDEMELVDLGDGRDKDCNLSVKNA------FKL 530
           LF   L+  K    RR + Y YKG +                 CNLSV  +      FK+
Sbjct: 339 LFSRMLLVAK----RRGLEYTYKGHIFC---------------CNLSVSESPRDPLGFKV 379

Query: 531 VSRTTDE-VYLFCAKKQEDKARWL 553
              T  +  +L  AK QE+K  W+
Sbjct: 380 SDLTIPKHRHLLQAKNQEEKRLWI 403


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score =  114 bits (285), Expect = 3e-25
 Identities = 125/460 (27%), Positives = 202/460 (43%), Gaps = 98/460 (21%)

Query: 211  SENSSST-------PSEEQDEEASQSRH------RHCENKQQMRTNVIREIMDTERVYIK 257
            SENSSS        P      E S+SR          E+   +R +V+ E++DTER Y++
Sbjct: 616  SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE 675

Query: 258  HLRDICEGYIRQCRK-------HTGMFTVAQLATIFGNIEDIYKFQRK-FLKDLEKQYNK 309
             L  + EGY  +           TG+     +  +FGN+E+IY F  + FL++LE   + 
Sbjct: 676  ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV--LFGNMEEIYHFHNRIFLRELENYTDC 733

Query: 310  EEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMID 369
             E     +G CFL+  E F IY +YC N P +     +L +Q     FF+ C   Q+ +D
Sbjct: 734  PEL----VGRCFLERMEDFQIYEKYCQNKPRS----ESLWRQCSDCPFFQEC---QRKLD 782

Query: 370  --IAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRK 427
              +++D +LL PVQ+I KY L L E+LKY+        N + A +  + ++ ++   K  
Sbjct: 783  HKLSLDSYLLKPVQRITKYQLLLKEMLKYS-------RNCEGAEDLQEALSSILGILKAV 835

Query: 428  LESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKIT--KQG----------KSQQRT 475
             +S+  IA     I G++G   L    +L+  G  +  T  K+G          K  QR 
Sbjct: 836  NDSMHLIA-----ITGYDG--NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRH 888

Query: 476  FFLFDHQLVSCKK------DLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFK 529
             FL +  ++ CKK         +     YK  L+M  + + +   G  K         F+
Sbjct: 889  LFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAK--------KFE 940

Query: 530  LVSRTTDEVYLFCAKKQEDKARW-----------LQAC--ADERRRVQEDKEMGMEISE- 575
            +     +EVY+  A   E KA W           LQAC  A + R +++ + + +     
Sbjct: 941  IWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTS 1000

Query: 576  ------NQKKLAMLNAQKAGHGKSKGY-NRCPVA-PPHQG 607
                  N + +  L  +K      +GY +  P+  PP +G
Sbjct: 1001 TSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKG 1040



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 2/75 (2%)

Query: 157  DHVTMDDQELGFKAGDVIQVLEASNKDWWWGR--SEDKEAWFPASFVRLRVNQEELSENS 214
            DH       L  ++GDV+++++  ++  W+ R  +  KE W PAS + +R+     ++  
Sbjct: 1092 DHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCL 1151

Query: 215  SSTPSEEQDEEASQS 229
            SS+ S       S S
Sbjct: 1152 SSSESSPGSAVLSNS 1166


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score =  114 bits (285), Expect = 3e-25
 Identities = 125/460 (27%), Positives = 202/460 (43%), Gaps = 98/460 (21%)

Query: 211 SENSSST-------PSEEQDEEASQSRH------RHCENKQQMRTNVIREIMDTERVYIK 257
           SENSSS        P      E S+SR          E+   +R +V+ E++DTER Y++
Sbjct: 563 SENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE 622

Query: 258 HLRDICEGYIRQCRK-------HTGMFTVAQLATIFGNIEDIYKFQRK-FLKDLEKQYNK 309
            L  + EGY  +           TG+     +  +FGN+E+IY F  + FL++LE   + 
Sbjct: 623 ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV--LFGNMEEIYHFHNRIFLRELENYTDC 680

Query: 310 EEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMID 369
            E     +G CFL+  E F IY +YC N P +     +L +Q     FF+ C   Q+ +D
Sbjct: 681 PEL----VGRCFLERMEDFQIYEKYCQNKPRS----ESLWRQCSDCPFFQEC---QRKLD 729

Query: 370 --IAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRK 427
             +++D +LL PVQ+I KY L L E+LKY+        N + A +  + ++ ++   K  
Sbjct: 730 HKLSLDSYLLKPVQRITKYQLLLKEMLKYS-------RNCEGAEDLQEALSSILGILKAV 782

Query: 428 LESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKIT--KQG----------KSQQRT 475
            +S+  IA     I G++G   L    +L+  G  +  T  K+G          K  QR 
Sbjct: 783 NDSMHLIA-----ITGYDG--NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRH 835

Query: 476 FFLFDHQLVSCKK------DLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFK 529
            FL +  ++ CKK         +     YK  L+M  + + +   G  K         F+
Sbjct: 836 LFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAK--------KFE 887

Query: 530 LVSRTTDEVYLFCAKKQEDKARW-----------LQAC--ADERRRVQEDKEMGMEISE- 575
           +     +EVY+  A   E KA W           LQAC  A + R +++ + + +     
Sbjct: 888 IWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTS 947

Query: 576 ------NQKKLAMLNAQKAGHGKSKGY-NRCPVA-PPHQG 607
                 N + +  L  +K      +GY +  P+  PP +G
Sbjct: 948 TSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKG 987



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 2/75 (2%)

Query: 157  DHVTMDDQELGFKAGDVIQVLEASNKDWWWGR--SEDKEAWFPASFVRLRVNQEELSENS 214
            DH       L  ++GDV+++++  ++  W+ R  +  KE W PAS + +R+     ++  
Sbjct: 1039 DHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCL 1098

Query: 215  SSTPSEEQDEEASQS 229
            SS+ S       S S
Sbjct: 1099 SSSESSPGSAVLSNS 1113


>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
           sapiens]
          Length = 776

 Score =  112 bits (281), Expect = 8e-25
 Identities = 104/447 (23%), Positives = 192/447 (42%), Gaps = 42/447 (9%)

Query: 162 DDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEE 221
           ++ EL    GD+I V       WW G    +  WFP+++VR    + + SE   S  + +
Sbjct: 175 NEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVR----EIKSSERPLSPKAVK 230

Query: 222 QDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQ 281
             E A  +++ +        T V++ I+DTE+ Y K L+ +   Y+R  + +  + TV +
Sbjct: 231 GFETAPLTKNYY--------TVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTV-E 281

Query: 282 LATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGF-AIYSEYCNNHPG 340
           + ++ GN E++  FQ+   + LE + +K   +  ++G C L     F ++Y  YC NHP 
Sbjct: 282 VTSLLGNFEEVCTFQQTLCQALE-ECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPS 340

Query: 341 ACLELANLMKQ--GKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTT 398
           A     N++ Q   +   F E        I + +   L  P  ++ KY   L EL ++  
Sbjct: 341 A----VNVLTQHSDELEQFMENQGASSPGI-LILTTNLSKPFMRLEKYVTLLQELERHME 395

Query: 399 QEHGDYSNIKAAYEAMKNVACLINE-RKRKLESIDKIARWQVSIVGWEGLDILDRSSELI 457
             H D+ +I  A  A K +     + RKRK   +  ++     I  WEG DI +  + + 
Sbjct: 396 DTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSE---PIQAWEGEDIKNLGNVIF 452

Query: 458 HSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRD 517
            S  + +     + ++R   LF + L+       R     Y+G++ +    +  L +   
Sbjct: 453 MSQVMVQYGACEEKEERYLMLFSNVLIMLSAS-PRMSGFIYQGKIPIAGTVVTRLDEIEG 511

Query: 518 KDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQ 577
            DC       F++   T + + + C   Q D   WL    ++  R+         +S+  
Sbjct: 512 NDC------TFEITGNTVERIVVHCNNNQ-DFQEWL----EQLNRLIRGPASCSSLSKTS 560

Query: 578 KKLAMLNAQKAGHGKSKGYNRCPVAPP 604
                 ++  +  G+ +G    P+ PP
Sbjct: 561 SSSCSAHSSFSSTGQPRG----PLEPP 583


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  109 bits (272), Expect = 9e-24
 Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 28/343 (8%)

Query: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
            A++D+   ++ EL F  G +I V+   + DWW G        FP+++V++  +    S+ 
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD----SDP 1162

Query: 214  SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
            S    ++ Q  +  Q   R        R   I E++ TE  Y+  L+ + E + ++  + 
Sbjct: 1163 SQQWCADLQTLDTMQPIERK-------RQGYIHELIQTEERYMADLQLVVEVFQKRMAE- 1214

Query: 274  TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQEGFAIY 331
            +G  T  ++A IF N +++     K LK L   K+   E+  +  IG            Y
Sbjct: 1215 SGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAY 1274

Query: 332  SEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQL 390
              +C+    GA L      +   ++ F +      +   + +  FLL P+Q+I +YPL +
Sbjct: 1275 IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLI 1334

Query: 391  AELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGL--D 448
              +L+ T + H D+S++K A E  + +   +NE  R+ E+ D++  W  + V  EGL   
Sbjct: 1335 RSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQ 1393

Query: 449  ILDRS-------SELIHSGELTKITKQGKSQQRTFFLFDHQLV 484
            ++  S        +L+HSG+L K TK  K      FLF+  L+
Sbjct: 1394 LIFNSLTNCLGPRKLLHSGKLYK-TKSNKELHG--FLFNDFLL 1433



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 14/121 (11%)

Query: 92  MRASNVSSD--GGTEPSALVD-DNGSEEDFSYEDLCQ---ASPRYLQPGGEQLAINELIS 145
           + A++ SS+     +P+++ D  N S  + +     Q   A  R + PG    +++ +  
Sbjct: 811 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPG----SVSPIHG 866

Query: 146 DGNVV---CAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202
            G VV    A+AL       D  L F   D+I VLE   ++WW+G       WFP S+V+
Sbjct: 867 QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVK 925

Query: 203 L 203
           +
Sbjct: 926 I 926



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)

Query: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
            AL+ + +++  +L F  G+ I V +    +WW G   D+   FP+++V+ + +QE     
Sbjct: 961  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVKPK-DQESFGSA 1018

Query: 214  SSSTPSEEQDEEA 226
            S S  S ++ E A
Sbjct: 1019 SKSGASNKKPEIA 1031



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 154 ALWDHVTMDDQELGFKAGDVIQVLE--ASNKDWWWGRSEDKEAWFPASFVRLRVNQE 208
           AL+     +  E+ F +GD+IQV E       W +G  +    WFP ++V    + E
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 793


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  109 bits (272), Expect = 9e-24
 Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 28/343 (8%)

Query: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
            A++D+   ++ EL F  G +I V+   + DWW G        FP+++V++  +    S+ 
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD----SDP 1189

Query: 214  SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
            S    ++ Q  +  Q   R        R   I E++ TE  Y+  L+ + E + ++  + 
Sbjct: 1190 SQQWCADLQTLDTMQPIERK-------RQGYIHELIQTEERYMADLQLVVEVFQKRMAE- 1241

Query: 274  TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQEGFAIY 331
            +G  T  ++A IF N +++     K LK L   K+   E+  +  IG            Y
Sbjct: 1242 SGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAY 1301

Query: 332  SEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQL 390
              +C+    GA L      +   ++ F +      +   + +  FLL P+Q+I +YPL +
Sbjct: 1302 IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLI 1361

Query: 391  AELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGL--D 448
              +L+ T + H D+S++K A E  + +   +NE  R+ E+ D++  W  + V  EGL   
Sbjct: 1362 RSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQ 1420

Query: 449  ILDRS-------SELIHSGELTKITKQGKSQQRTFFLFDHQLV 484
            ++  S        +L+HSG+L K TK  K      FLF+  L+
Sbjct: 1421 LIFNSLTNCLGPRKLLHSGKLYK-TKSNKELHG--FLFNDFLL 1460



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 14/121 (11%)

Query: 92  MRASNVSSD--GGTEPSALVD-DNGSEEDFSYEDLCQ---ASPRYLQPGGEQLAINELIS 145
           + A++ SS+     +P+++ D  N S  + +     Q   A  R + PG    +++ +  
Sbjct: 838 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPG----SVSPIHG 893

Query: 146 DGNVV---CAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202
            G VV    A+AL       D  L F   D+I VLE   ++WW+G       WFP S+V+
Sbjct: 894 QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVK 952

Query: 203 L 203
           +
Sbjct: 953 I 953



 Score = 36.2 bits (82), Expect = 0.097
 Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)

Query: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
            AL+ + +++  +L F  G+ I V +    +WW G   D+   FP+++V+ + +QE     
Sbjct: 988  ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVKPK-DQESFGSA 1045

Query: 214  SSSTPSEEQDEEA 226
            S S  S ++ E A
Sbjct: 1046 SKSGASNKKPEIA 1058



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 154 ALWDHVTMDDQELGFKAGDVIQVLE--ASNKDWWWGRSEDKEAWFPASFVRLRVNQE 208
           AL+     +  E+ F +GD+IQV E       W +G  +    WFP ++V    + E
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 820


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score =  105 bits (262), Expect = 1e-22
 Identities = 86/318 (27%), Positives = 144/318 (45%), Gaps = 20/318 (6%)

Query: 244 VIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDL 303
           +++EI+ TER Y+K L  I   +     K   M     +  +F NI+ IY+F R FL+++
Sbjct: 539 IVKEILATERTYLKDLEVITVWFRSAVVKEDAM-PATLMTLLFSNIDPIYEFHRGFLREV 597

Query: 304 EKQY----NKEEPHLS----EIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYR 355
           E++        + H       IG   L+N      ++ Y   H     EL    K+ K  
Sbjct: 598 EQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKL 657

Query: 356 HFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMK 415
                   LQ++  + ++ FLL P+Q++  Y L L  L  + +  H DY++   A +A+ 
Sbjct: 658 EAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAIT 717

Query: 416 NVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRT 475
            V   +     +LE++ K+   Q  +VG E L  +    E I  G L K+TK+G  QQR 
Sbjct: 718 EVTTTLQHILIRLENLQKLTELQRDLVGIENL--IAPGREFIREGCLHKLTKKG-LQQRM 774

Query: 476 FFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTT 535
           FFLF   L+   K +        +G L +  M LV+     + D   SV + F + +   
Sbjct: 775 FFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGM-LVE-----ESDNEWSVPHCFTIYA--A 826

Query: 536 DEVYLFCAKKQEDKARWL 553
            +  +  A  + +K +W+
Sbjct: 827 QKTIVVAASTRLEKEKWM 844


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score =  104 bits (260), Expect = 2e-22
 Identities = 94/338 (27%), Positives = 158/338 (46%), Gaps = 29/338 (8%)

Query: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300
           R   + EI +TE  Y + L DI + Y+   R    + + A +A +F N+ED+ K    FL
Sbjct: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHHSFL 255

Query: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFE 359
           + ++         L+++   FL  +E   IY EYC++   A   L  L+   + +R   E
Sbjct: 256 RAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVE 312

Query: 360 ACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVAC 419
            C L  Q     +   L+ P+Q++ KY L L ELL ++  E  +   +K A EAM+++A 
Sbjct: 313 ECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAM 371

Query: 420 LINERKRKLESIDKIARWQVSIVGWEGLDI-LDRSSELIHSGEL-TKITKQGKSQQRTFF 477
            INE KR  E++ KI+ +Q SI   E L + L+        GEL  +       Q R  F
Sbjct: 372 YINEVKRDKETLRKISEFQSSI---ENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLF 428

Query: 478 LFDHQLVSCK--------KDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFK 529
           LFD  ++ CK        K+++  ++L++K  +  D M   D+     K  +      F 
Sbjct: 429 LFDKVVIVCKRKGYSYELKEII--ELLFHK--MTDDPMNNKDVKKSHGKMWSY----GFY 480

Query: 530 LVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDK 567
           L+     + + F  K ++ K +W++        ++ DK
Sbjct: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 518



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 152 AEALWDHVTMDDQELGFKAGDVIQVLEASNKD--WWWGRSEDKEAWFPASFV 201
           A A ++    D +EL  + GDV+++      D  WW G +  +  WFP+++V
Sbjct: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score =  103 bits (256), Expect = 6e-22
 Identities = 93/336 (27%), Positives = 156/336 (46%), Gaps = 30/336 (8%)

Query: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300
           R   + EI +TE  Y + L DI + Y+   R    + + A +A +F N+ED+ K    FL
Sbjct: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHHSFL 250

Query: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFE 359
           + ++         L+++   FL  +E   IY EYC++   A   L  L+   + +R   E
Sbjct: 251 RAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVE 307

Query: 360 ACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVAC 419
            C L  Q     +   L+ P+Q++ KY L L ELL ++  E  +   +K A EAM+++A 
Sbjct: 308 ECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAM 366

Query: 420 LINERKRKLESIDKIARWQVSIVGWEGLDI-LDRSSELIHSGEL-TKITKQGKSQQRTFF 477
            INE KR  E++ KI+ +Q SI   E L + L+        GEL  +       Q R  F
Sbjct: 367 YINEVKRDKETLRKISEFQSSI---ENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLF 423

Query: 478 LFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKN------AFKLV 531
           LFD  ++ CK+          KG    +  E+++L   +  D  ++ K+       F L+
Sbjct: 424 LFDKVVIVCKR----------KG-YSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLI 472

Query: 532 SRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDK 567
                + + F  K ++ K +W++        ++ DK
Sbjct: 473 HLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 508



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 152 AEALWDHVTMDDQELGFKAGDVIQVLEASNKD--WWWGRSEDKEAWFPASFV 201
           A A ++    D +EL  + GDV+++      D  WW G +  +  WFP+++V
Sbjct: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  102 bits (253), Expect = 1e-21
 Identities = 85/350 (24%), Positives = 159/350 (45%), Gaps = 44/350 (12%)

Query: 155  LWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENS 214
            ++D+   +D EL F  G +I VL   + DWW G    +   FP+++V+L  + +   +  
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWC 1222

Query: 215  SS-------TPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYI 267
            S        TP+E +                  R   I E++ TE  Y+  L+ + E + 
Sbjct: 1223 SDLHLLDMLTPTERK------------------RQGYIHELIVTEENYVNDLQLVTEIFQ 1264

Query: 268  RQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQ 325
            +   + + + T  ++A IF N +++     K LK L   K+ + E+  +  IG       
Sbjct: 1265 KPLME-SELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQL 1323

Query: 326  EGFAIYSEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKIC 384
                 Y  +C+    GA L      +   ++ F +   +  +   + +  F+L P+Q++ 
Sbjct: 1324 PHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVT 1383

Query: 385  KYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGW 444
            +YPL +  +L+ T + H D+S++K A E  + +   +NE  R+ E+ D++  W  + V  
Sbjct: 1384 RYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRL-EWIQAHVQC 1442

Query: 445  EGL--DILDRS-------SELIHSGELTKITKQGKSQQRTF-FLFDHQLV 484
            EGL   ++  S        + +HSG+L K     KS +  + FLF+  L+
Sbjct: 1443 EGLSEQLVFNSVTNCLGPRKFLHSGKLYK----AKSNKELYGFLFNDFLL 1488



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 25/69 (36%), Positives = 35/69 (50%), Gaps = 1/69 (1%)

Query: 152 AEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELS 211
           A+AL+      D  L F   DVI VLE  +  WW+G  + ++ WFP S+V+L       S
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKS 976

Query: 212 ENSSSTPSE 220
            +  S  SE
Sbjct: 977 TSMDSGSSE 985



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 3/75 (4%)

Query: 154  ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
            A++ + + +  +L F+ GDVI V +    DWW G   DK   FP+++VRL+    E S  
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKKDG-DWWTGTVGDKAGVFPSNYVRLK--DSEGSGT 1065

Query: 214  SSSTPSEEQDEEASQ 228
            +  T S  +  E +Q
Sbjct: 1066 AGKTGSLGKKPEIAQ 1080



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 20/86 (23%), Positives = 34/86 (39%), Gaps = 13/86 (15%)

Query: 149 VVCAEALWDHVTMDDQELGFKAGDVIQVL-------EASNKDWWWGRSEDKEAWFPASFV 201
           VV   AL+   +    E+  + GD++ V        +     W  G  + K  WFPA++ 
Sbjct: 742 VVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYA 801

Query: 202 RLRVNQEELSENSSSTPSEEQDEEAS 227
                 E++ EN    P +   +  S
Sbjct: 802 ------EKIPENEVPAPVKPVTDSTS 821



 Score = 30.0 bits (66), Expect = 7.0
 Identities = 48/206 (23%), Positives = 92/206 (44%), Gaps = 16/206 (7%)

Query: 392 ELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILD 451
           ELL    +E  D   +KA  + ++     +N++K +LE   +  R +++    E ++  +
Sbjct: 456 ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQE-IESTN 514

Query: 452 RSSELIHSGELTKITKQGKSQQRTF-------FLFDHQLVSCKKDLLRRDMLY-YKGRLD 503
           +S EL    E+T + +Q +  Q+          + + QL   +++ L RD L   K  L+
Sbjct: 515 KSREL-RIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALE 573

Query: 504 MDEMELVDLGDGRD--KDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERR 561
             E+    L D  D  +    S      + +    E+     K+Q  K + ++A   ER 
Sbjct: 574 AKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEA---ERL 630

Query: 562 RVQEDKEMGMEISENQKKLAMLNAQK 587
           + +E +   +E+ E QK+ A   AQ+
Sbjct: 631 KQKEQERKIIEL-EKQKEEAQRRAQE 655


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
          Length = 1591

 Score =  100 bits (248), Expect = 5e-21
 Identities = 77/295 (26%), Positives = 136/295 (46%), Gaps = 22/295 (7%)

Query: 214  SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
            S  +PS +       +  R   +  ++R  VI E+++TER Y+K L  + E Y++  +K 
Sbjct: 1015 SDQSPSPQDSTGPQLATMRQLSDADKLR-KVICELLETERTYVKDLNCLMERYLKPLQKE 1073

Query: 274  TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE------------KQYNKEEPHLSEIGSCF 321
            T   T  +L  +FGN+ ++ +FQ +FLK LE            ++ ++ +  L  +G  F
Sbjct: 1074 T-FLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSF 1132

Query: 322  LQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQ 381
            L   + F +YS +C +H      L        ++ F +A    QQ     ++ +L+ P+Q
Sbjct: 1133 LYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPKQQHSS-TLESYLIKPIQ 1191

Query: 382  KICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSI 441
            +I KYPL L EL   T  E  ++ ++  A + M  VA  INE ++  E    +    ++ 
Sbjct: 1192 RILKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAE 1251

Query: 442  VGWEGLDILDRS--SELIHSGEL-----TKITKQGKSQQRTFFLFDHQLVSCKKD 489
               E  ++ D S    L+H+  +       + K  K  +   F+F   +V   KD
Sbjct: 1252 QTGEKKEVADLSMGDLLLHTTVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKD 1306


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 84/335 (25%), Positives = 160/335 (47%), Gaps = 15/335 (4%)

Query: 222 QDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQ 281
           +D   ++  H+    +  +R+  + EI  TE  Y + L  I + ++   ++     T A+
Sbjct: 174 EDLMKAEEAHQPKCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKR---FLTAAE 230

Query: 282 LATIFGNIEDIYKFQRKFLKDLEKQY-NKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPG 340
             ++F NI ++ K  R  ++++     NK + +L ++   F+  +E   IY +YC+    
Sbjct: 231 FDSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQV---FINYKERLVIYGQYCSGVES 287

Query: 341 ACLELANLMKQGK-YRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQ 399
           A   L  + K  +  +   E C          +   L+ P+Q++ KY L L EL+K+TT 
Sbjct: 288 AISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTT- 346

Query: 400 EHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHS 459
           +  + +N+K A +AMK++A  +NE KR  E++ +I ++Q+SI       +L    +    
Sbjct: 347 DPTEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGE 406

Query: 460 GELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKD 519
             +T + K  K Q+R  FLFD  ++ CK+   + D    K  +D+ + ++ +     DK+
Sbjct: 407 IRITTLDKHTK-QERHIFLFDLAVIVCKR---KGDNYEMKEIIDLQQYKIAN-NPTTDKE 461

Query: 520 CNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQ 554
            N      F L+         F  K ++ K +WL+
Sbjct: 462 -NKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLE 495



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 1/62 (1%)

Query: 141 NELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQV-LEASNKDWWWGRSEDKEAWFPAS 199
           N L+S   +  A A +D    D +EL    GDV+++  + S   WW G    +  WFP++
Sbjct: 782 NSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPST 841

Query: 200 FV 201
           +V
Sbjct: 842 YV 843


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 100/383 (26%), Positives = 171/383 (44%), Gaps = 68/383 (17%)

Query: 209 ELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR 268
           +  E  SS PS   D   S            ++ +V+ E++ TERVY++ L  +  GY R
Sbjct: 533 DCQEKRSSGPSSSLDNGNSLD---------VLKNHVLNELIQTERVYVRELYTVLLGY-R 582

Query: 269 QCRKHTGMFTVA------QLATIFGNIEDIYKFQRK-FLKDLEKQYNKEEPHLSEIGSCF 321
               +  MF +       +   +FGN+ +IY+F    FL  LE   +  E     +G CF
Sbjct: 583 AEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCF 638

Query: 322 LQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEAC-RLLQQMIDIAIDGFLLTPV 380
           L+ ++ F +Y++YC N P +      + ++     FF+ C R L+  +   +D +LL PV
Sbjct: 639 LERKDDFQMYAKYCQNKPRS----ETIWRKYSECAFFQECQRKLKHRL--RLDSYLLKPV 692

Query: 381 QKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440
           Q+I KY L L ELLKY+    G  + +K A +AM ++   +N+           +  Q++
Sbjct: 693 QRITKYQLLLKELLKYSKDCEGS-ALLKKALDAMLDLLKSVND-----------SMHQIA 740

Query: 441 IVGWEGLDILDRSSELIHSGELT------------KITKQGKSQQRTFFLFDHQLVSCKK 488
           I G+ G   L+   ++I  G  +            K   + K  QR  FL++  +V CK+
Sbjct: 741 INGYIG--NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKR 798

Query: 489 DLL------RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFC 542
            +       R     +K    MDE+ + +   G ++         F++     +EVY+  
Sbjct: 799 RVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQ 850

Query: 543 AKKQEDKARWLQACADERRRVQE 565
           A   + K  WL+   +   + QE
Sbjct: 851 ASNVDVKMTWLKEIRNILLKQQE 873


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 100/383 (26%), Positives = 171/383 (44%), Gaps = 68/383 (17%)

Query: 209 ELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIR 268
           +  E  SS PS   D   S            ++ +V+ E++ TERVY++ L  +  GY R
Sbjct: 473 DCQEKRSSGPSSSLDNGNSLD---------VLKNHVLNELIQTERVYVRELYTVLLGY-R 522

Query: 269 QCRKHTGMFTVA------QLATIFGNIEDIYKFQRK-FLKDLEKQYNKEEPHLSEIGSCF 321
               +  MF +       +   +FGN+ +IY+F    FL  LE   +  E     +G CF
Sbjct: 523 AEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPE----RVGPCF 578

Query: 322 LQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEAC-RLLQQMIDIAIDGFLLTPV 380
           L+ ++ F +Y++YC N P +      + ++     FF+ C R L+  +   +D +LL PV
Sbjct: 579 LERKDDFQMYAKYCQNKPRS----ETIWRKYSECAFFQECQRKLKHRL--RLDSYLLKPV 632

Query: 381 QKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440
           Q+I KY L L ELLKY+    G  + +K A +AM ++   +N+           +  Q++
Sbjct: 633 QRITKYQLLLKELLKYSKDCEGS-ALLKKALDAMLDLLKSVND-----------SMHQIA 680

Query: 441 IVGWEGLDILDRSSELIHSGELT------------KITKQGKSQQRTFFLFDHQLVSCKK 488
           I G+ G   L+   ++I  G  +            K   + K  QR  FL++  +V CK+
Sbjct: 681 INGYIG--NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKR 738

Query: 489 DLL------RRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFC 542
            +       R     +K    MDE+ + +   G ++         F++     +EVY+  
Sbjct: 739 RVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNR--------KFEIWYGEKEEVYIVQ 790

Query: 543 AKKQEDKARWLQACADERRRVQE 565
           A   + K  WL+   +   + QE
Sbjct: 791 ASNVDVKMTWLKEIRNILLKQQE 813


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 79/296 (26%), Positives = 137/296 (46%), Gaps = 23/296 (7%)

Query: 213  NSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRK 272
            N    P E QD    +   RH  +  ++R  VI+E++DTE+ Y+K L  + E Y+   + 
Sbjct: 1074 NGMEGPRENQDPPP-RPLARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPLQN 1131

Query: 273  HTGMFTVAQLATIFGNIEDIYKFQRKFLKDLE------KQYNKEEPH------LSEIGSC 320
             T   T  ++ ++FG++ ++ +FQ+ FL+ LE        +N  E        L  +G  
Sbjct: 1132 ET-FLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGS 1190

Query: 321  FLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPV 380
            FL   + F +YS +C NH      L        ++ F +A    +Q     ++ +L+ PV
Sbjct: 1191 FLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIKPV 1249

Query: 381  QKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVS 440
            Q++ KYPL L EL+  T QE  ++ ++  A +AM+ VA  INE ++  E    +    V+
Sbjct: 1250 QRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVA 1309

Query: 441  IVGWEGLDI--LDRSSELIHS-----GELTKITKQGKSQQRTFFLFDHQLVSCKKD 489
                   ++  L     L+HS          + K  K  + T F+F   ++   K+
Sbjct: 1310 EQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKE 1365


>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
           [Homo sapiens]
          Length = 626

 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 78/291 (26%), Positives = 136/291 (46%), Gaps = 23/291 (7%)

Query: 218 PSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMF 277
           P E QD    +   RH  +  ++R  VI+E++DTE+ Y+K L  + E Y+   +  T   
Sbjct: 4   PRENQDPPP-RPLARHLSDADRLR-KVIQELVDTEKSYVKDLSCLFELYLEPLQNET-FL 60

Query: 278 TVAQLATIFGNIEDIYKFQRKFLKDLE------KQYNKEEPH------LSEIGSCFLQNQ 325
           T  ++ ++FG++ ++ +FQ+ FL+ LE        +N  E        L  +G  FL   
Sbjct: 61  TQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYA 120

Query: 326 EGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICK 385
           + F +YS +C NH      L        ++ F +A    +Q     ++ +L+ PVQ++ K
Sbjct: 121 DHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSS-TLESYLIKPVQRVLK 179

Query: 386 YPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWE 445
           YPL L EL+  T QE  ++ ++  A +AM+ VA  INE ++  E    +    V+     
Sbjct: 180 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 239

Query: 446 GLDI--LDRSSELIHS-----GELTKITKQGKSQQRTFFLFDHQLVSCKKD 489
             ++  L     L+HS          + K  K  + T F+F   ++   K+
Sbjct: 240 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKE 290


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 85/319 (26%), Positives = 149/319 (46%), Gaps = 29/319 (9%)

Query: 245 IREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLE 304
           +REI  TE  Y   L  I + +++  ++         +  IF NIED+ +    FLK+++
Sbjct: 199 LREIQQTEEKYTDTLGSIQQHFLKPLQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMK 255

Query: 305 KQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFEACRL 363
           +      P  + +   F++ +E F +Y  YC+    A   L  +    +  +   E C  
Sbjct: 256 EALGT--PGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQ 313

Query: 364 LQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE 423
                   +   L+ P+Q++ KY L L EL+K+T QE  +  N++ A +AM+++A  +NE
Sbjct: 314 RANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALDAMRDLAQCVNE 372

Query: 424 RKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSG--------ELTKITKQGKSQQRT 475
            KR  E++ +I  +Q+SI   E LD       L H G        ++T + ++ K   R 
Sbjct: 373 VKRDNETLRQITNFQLSI---ENLD-----QSLAHYGRPKIDGELKITSVERRSK-MDRY 423

Query: 476 FFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTT 535
            FL D  L+ CK+   R D    K  +++   ++ D   G D+D N    + F L+    
Sbjct: 424 AFLLDKALLICKR---RGDSYDLKDFVNLHSFQVRDDSSG-DRD-NKKWSHMFLLIEDQG 478

Query: 536 DEVYLFCAKKQEDKARWLQ 554
            + Y    K +E K +W++
Sbjct: 479 AQGYELFFKTRELKKKWME 497



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 14/135 (10%)

Query: 79  TPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQL 138
           T  GL R+  ++  R       G TE       N  ++ F   D     P + +P    +
Sbjct: 722 TAEGLYRITEKKAFR-------GLTELVEFYQQNSLKDCFKSLDTTLQFP-FKEPEKRTI 773

Query: 139 AINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWW-GRSEDKEAWFP 197
           +   + S      A+A +D    D  EL  K GD+I++L    +  WW G    +  WFP
Sbjct: 774 SRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFP 833

Query: 198 ASFVRLRVNQEELSE 212
           A++V     +E+ SE
Sbjct: 834 ANYV-----EEDYSE 843


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,750,819
Number of Sequences: 37866
Number of extensions: 1194937
Number of successful extensions: 5231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 4557
Number of HSP's gapped (non-prelim): 581
length of query: 652
length of database: 18,247,518
effective HSP length: 109
effective length of query: 543
effective length of database: 14,120,124
effective search space: 7667227332
effective search space used: 7667227332
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.