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Search of human proteins with 23110942
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
(241 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 472 e-133
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 157 6e-39
gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 152 3e-37
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 151 6e-37
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 133 2e-31
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 129 3e-30
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 129 3e-30
gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 126 1e-29
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] 122 3e-28
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 121 6e-28
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 121 6e-28
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 120 1e-27
gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 115 4e-26
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 79 4e-15
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] 78 8e-15
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 66 3e-11
gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom... 54 9e-08
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo... 54 9e-08
gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens] 49 3e-06
gi|153791216 proteasome beta 11 subunit [Homo sapiens] 47 1e-05
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens] 47 2e-05
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] 42 5e-04
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] 42 5e-04
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] 42 5e-04
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo... 41 0.001
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ... 41 0.001
gi|221316624 dystonin isoform 4 [Homo sapiens] 32 0.49
gi|221316622 dystonin isoform 3 [Homo sapiens] 32 0.49
gi|221316618 dystonin isoform 2 [Homo sapiens] 32 0.49
gi|34577047 dystonin isoform 1 [Homo sapiens] 32 0.49
>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
Length = 241
Score = 472 bits (1214), Expect = e-133
Identities = 241/241 (100%), Positives = 241/241 (100%)
Query: 1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME 60
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
Sbjct: 1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME 60
Query: 61 PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA 120
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
Sbjct: 61 PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA 120
Query: 121 LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS 180
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
Sbjct: 121 LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS 180
Query: 181 LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD 240
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
Sbjct: 181 LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD 240
Query: 241 I 241
I
Sbjct: 241 I 241
>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
Length = 250
Score = 157 bits (398), Expect = 6e-39
Identities = 90/239 (37%), Positives = 144/239 (60%), Gaps = 10/239 (4%)
Query: 6 SEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65
S YDR + FSP+G LFQVEYA EA+K GSTA+GI+ + V L VEK+ + L + ++
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
Query: 66 KIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGE 125
KI +D H+ A +GL ADA+ +I++ARVE Q+H T + +TVE +T+ ++ L ++ +
Sbjct: 63 KICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 122
Query: 126 EDADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEV 184
+ RPFG++ L G D+ G +L+ DPSGT+ A AIG +++ + L++
Sbjct: 123 SNG-----RRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKN 177
Query: 185 YHKSMTL--KEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241
Y + EAIK ++ L +V++ NIELA ++ Q MF+ +E+E + +I
Sbjct: 178 YTEDAIASDSEAIKLAIKALLEVVQS--GGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234
>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
Length = 248
Score = 152 bits (384), Expect = 3e-37
Identities = 87/240 (36%), Positives = 143/240 (59%), Gaps = 16/240 (6%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67
YDR + FSP+G LFQVEYA EA+K GSTA+G++ + V L VEK+ + L + ++ KI
Sbjct: 3 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62
Query: 68 VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127
+D ++ A +GL ADA+ +I++ARVE Q+H T + +TVE +T+ +++L ++ + +
Sbjct: 63 CALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSN 122
Query: 128 ADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYH 186
RPFG++ L G D G P+L+ DPSGT+ A AIG ++ + L++ Y
Sbjct: 123 G-----RRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNY- 176
Query: 187 KSMTLKEAIKSSLIILKQVMEEKLNAT-----NIELATVQPGQNFHMFTKEELEEVIKDI 241
EAI++ + +K V++ L NIELA ++ Q+ + EE+E+ + +I
Sbjct: 177 ----TDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEI 232
>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
Length = 256
Score = 151 bits (381), Expect = 6e-37
Identities = 90/245 (36%), Positives = 144/245 (58%), Gaps = 16/245 (6%)
Query: 6 SEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65
S YDR + FSP+G LFQVEYA EA+K GSTA+GI+ + V L VEK+ + L + ++
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
Query: 66 KIVEIDAHIGCAMS------GLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNL 119
KI +D H+ A + GL ADA+ +I++ARVE Q+H T + +TVE +T+ ++ L
Sbjct: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
Query: 120 ALQFGEEDADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQ 178
++ + + RPFG++ L G D+ G +L+ DPSGT+ A AIG +++ +
Sbjct: 123 KQKYTQSNG-----RRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVR 177
Query: 179 SSLQEVYHKSMTL--KEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEE 236
L++ Y + EAIK ++ L +V++ NIELA ++ Q MF+ +E+E
Sbjct: 178 EFLEKNYTEDAIASDSEAIKLAIKALLEVVQS--GGKNIELAIIRRNQPLKMFSAKEVEL 235
Query: 237 VIKDI 241
+ +I
Sbjct: 236 YVTEI 240
>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
Length = 234
Score = 133 bits (334), Expect = 2e-31
Identities = 74/234 (31%), Positives = 127/234 (54%), Gaps = 6/234 (2%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67
Y + TFSP G+L Q+EYA+ A+ G+ ++GI+ + GV LA EK+ S L + S+ K+
Sbjct: 6 YSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKV 65
Query: 68 VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127
I HIG SG+ D + L+ +AR Q ++ Y E + + Q V+++ ++ +
Sbjct: 66 EPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSG 125
Query: 128 ADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHK 187
RPFGV+LL G +E P LF DPSG + A A+G ++ L++ Y++
Sbjct: 126 G-----VRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180
Query: 188 SMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241
+ L++AI ++++ LK+ E ++ NIE+ F T E+++ + I
Sbjct: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEA-GFRRLTPTEVKDYLAAI 233
>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 129 bits (323), Expect = 3e-30
Identities = 88/242 (36%), Positives = 140/242 (57%), Gaps = 18/242 (7%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKR-ITSPLMEPSSIEK 66
YD FSPEGRL+QVEYA+EAI T +GI ++GV LA E+R I L E EK
Sbjct: 5 YDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEK 64
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA---LQF 123
I +++ + C+++G+ +DA L ++ R+ Q + Y E + E + A+ ++ QF
Sbjct: 65 IYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQF 124
Query: 124 GEEDADPGAMSRPFGVALLFGGVDEK-GPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQ 182
G + RPFGV+LL+ G D+ G QL+ DPSG + A IG+ S A S L+
Sbjct: 125 GGK--------RPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLK 176
Query: 183 EVYHK-SMTLKEAIKSSLIILKQVME-EKLNATNIELATV--QPGQN-FHMFTKEELEEV 237
+ Y + MTLK A+ ++ +L + M+ KL+A +E+AT+ + G+ + ++E+E++
Sbjct: 177 QDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQL 236
Query: 238 IK 239
IK
Sbjct: 237 IK 238
>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 129 bits (323), Expect = 3e-30
Identities = 88/242 (36%), Positives = 140/242 (57%), Gaps = 18/242 (7%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKR-ITSPLMEPSSIEK 66
YD FSPEGRL+QVEYA+EAI T +GI ++GV LA E+R I L E EK
Sbjct: 5 YDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEK 64
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA---LQF 123
I +++ + C+++G+ +DA L ++ R+ Q + Y E + E + A+ ++ QF
Sbjct: 65 IYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQF 124
Query: 124 GEEDADPGAMSRPFGVALLFGGVDEK-GPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQ 182
G + RPFGV+LL+ G D+ G QL+ DPSG + A IG+ S A S L+
Sbjct: 125 GGK--------RPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLK 176
Query: 183 EVYHK-SMTLKEAIKSSLIILKQVME-EKLNATNIELATV--QPGQN-FHMFTKEELEEV 237
+ Y + MTLK A+ ++ +L + M+ KL+A +E+AT+ + G+ + ++E+E++
Sbjct: 177 QDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQL 236
Query: 238 IK 239
IK
Sbjct: 237 IK 238
>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
Length = 255
Score = 126 bits (317), Expect = 1e-29
Identities = 76/215 (35%), Positives = 121/215 (56%), Gaps = 7/215 (3%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67
YD +TFSP+GR+FQVEYA++A++ STAIGI+ +GV VEK + S L E S +++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 68 VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127
+D H+G A++GL+ADA++L D AR E N + + ++ + V+ +
Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
Query: 128 ADPGAMSRPFGVALLFGGVD-EKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYH 186
A RPFG + + G G QL+ +DPSG AIG A + A++ ++++
Sbjct: 128 A-----VRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQM 182
Query: 187 KSMTLKEAIKSSLIILKQVMEE-KLNATNIELATV 220
K MT ++ +K I+ V +E K A +EL+ V
Sbjct: 183 KEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWV 217
>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
Length = 248
Score = 122 bits (306), Expect = 3e-28
Identities = 75/214 (35%), Positives = 120/214 (56%), Gaps = 12/214 (5%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67
YD +TFSP+GR+FQVEYA++A++ STAIGI+ +GV VEK + S L E S +++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 68 VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127
+D H+G A++GL+ADA++L D AR E N + + ++ + V+ +
Sbjct: 68 FNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYS 127
Query: 128 ADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHK 187
A RPFG ++ G QL+ +DPSG AIG A + A++ ++++ K
Sbjct: 128 A-----VRPFGCSV------NDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMK 176
Query: 188 SMTLKEAIKSSLIILKQVMEE-KLNATNIELATV 220
MT ++ +K I+ V +E K A +EL+ V
Sbjct: 177 EMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWV 210
>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
Length = 263
Score = 121 bits (303), Expect = 6e-28
Identities = 74/243 (30%), Positives = 126/243 (51%), Gaps = 15/243 (6%)
Query: 5 RSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI 64
R++YD V +SP+GR+ Q+EYA+EA+K GS +G+++ L KR S L +
Sbjct: 3 RNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQ 60
Query: 65 EKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFG 124
+KI+ +D HIG +++GL ADA+ L + R E + F ++ + VS L G
Sbjct: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPL-------PVSRLVSLIG 113
Query: 125 EEDADPGAM--SRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQ 182
+ P RP+GV LL G D+ GP +F PS + C A +IG+ S+ A++ L+
Sbjct: 114 SKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 173
Query: 183 EVYHKSM--TLKEAIKSSLIILKQVM--EEKLNATNIELATVQPGQNFHMFTKEELEEVI 238
+ M L E +K L L++ + E+ L N+ + V F ++ +++ +
Sbjct: 174 RHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFL 233
Query: 239 KDI 241
+ +
Sbjct: 234 EGL 236
>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
Length = 269
Score = 121 bits (303), Expect = 6e-28
Identities = 74/243 (30%), Positives = 126/243 (51%), Gaps = 15/243 (6%)
Query: 5 RSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI 64
R++YD V +SP+GR+ Q+EYA+EA+K GS +G+++ L KR S L +
Sbjct: 9 RNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQ 66
Query: 65 EKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFG 124
+KI+ +D HIG +++GL ADA+ L + R E + F ++ + VS L G
Sbjct: 67 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPL-------PVSRLVSLIG 119
Query: 125 EEDADPGAM--SRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQ 182
+ P RP+GV LL G D+ GP +F PS + C A +IG+ S+ A++ L+
Sbjct: 120 SKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLE 179
Query: 183 EVYHKSM--TLKEAIKSSLIILKQVM--EEKLNATNIELATVQPGQNFHMFTKEELEEVI 238
+ M L E +K L L++ + E+ L N+ + V F ++ +++ +
Sbjct: 180 RHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFL 239
Query: 239 KDI 241
+ +
Sbjct: 240 EGL 242
>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
Length = 212
Score = 120 bits (300), Expect = 1e-27
Identities = 79/239 (33%), Positives = 124/239 (51%), Gaps = 48/239 (20%)
Query: 6 SEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65
S YDR + FSP+G LFQVEYA EA+K GSTA+GI+
Sbjct: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIR------------------------ 38
Query: 66 KIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGE 125
GL ADA+ +I++ARVE Q+H T + +TVE +T+ ++ L ++ +
Sbjct: 39 --------------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQ 84
Query: 126 EDADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEV 184
+ RPFG++ L G D+ G +L+ DPSGT+ A AIG +++ + L++
Sbjct: 85 SNG-----RRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKN 139
Query: 185 YHKSMTL--KEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241
Y + EAIK ++ L +V++ NIELA ++ Q MF+ +E+E + +I
Sbjct: 140 YTEDAIASDSEAIKLAIKALLEVVQS--GGKNIELAIIRRNQPLKMFSAKEVELYVTEI 196
>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
Length = 246
Score = 115 bits (287), Expect = 4e-26
Identities = 63/233 (27%), Positives = 127/233 (54%), Gaps = 10/233 (4%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGS-TAIGIQTSEGVCLAVEKRITSPLMEPSSIEK 66
+DR + FSPEGRL+QVEYA +AI G T++ ++ + + +K++ L++ S++
Sbjct: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEE 126
+ +I +IGC M+G+ AD+++ + +AR E N + Y + V+ + + +++++ + +
Sbjct: 69 LFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ- 127
Query: 127 DADPGAMSRPFGVALLFGGVD-EKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
A RP G ++ G+D E+GPQ++ DP+G + A A G + S L++
Sbjct: 128 ----NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKV 183
Query: 186 HKSM--TLKEAIKSSLIILKQVMEEKLNATNIELATVQ-PGQNFHMFTKEELE 235
K T ++ +++++ L V+ + IE+ V F + T+ E++
Sbjct: 184 KKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEID 236
>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
Length = 190
Score = 79.0 bits (193), Expect = 4e-15
Identities = 56/175 (32%), Positives = 99/175 (56%), Gaps = 17/175 (9%)
Query: 74 IGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA---LQFGEEDADP 130
+ C+++G+ +DA L ++ R+ Q + Y E + E + A+ ++ QFG +
Sbjct: 1 MACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGK---- 56
Query: 131 GAMSRPFGVALLFGGVDEK-GPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHK-S 188
RPFGV+LL+ G D+ G QL+ DPSG + A IG+ S A S L++ Y +
Sbjct: 57 ----RPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGE 112
Query: 189 MTLKEAIKSSLIILKQVME-EKLNATNIELATV--QPGQN-FHMFTKEELEEVIK 239
MTLK A+ ++ +L + M+ KL+A +E+AT+ + G+ + ++E+E++IK
Sbjct: 113 MTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIK 167
>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
Length = 130
Score = 77.8 bits (190), Expect = 8e-15
Identities = 40/117 (34%), Positives = 68/117 (58%), Gaps = 2/117 (1%)
Query: 5 RSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI 64
R++YD V +SP+GR+ Q+EYA+EA+K GS +G+++ L KR S L +
Sbjct: 3 RNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSEL--AAHQ 60
Query: 65 EKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLAL 121
+KI+ +D HIG +++GL ADA+ L + R E + F ++ + V + + + L
Sbjct: 61 KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSSIL 117
>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
Length = 273
Score = 65.9 bits (159), Expect = 3e-11
Identities = 46/166 (27%), Positives = 79/166 (47%), Gaps = 11/166 (6%)
Query: 30 AIKLGSTAIGIQTSEGVCLAVEKRITSP-LMEPSSIEKIVEIDAHIGCAMSGLIADAKTL 88
A K G+T G+ +GV L + R T+ ++ S EKI I I C +G+ ADA+
Sbjct: 35 ARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMT 94
Query: 89 IDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDE 148
+ + H + V +VT+ + ++ G +L+ GGVD
Sbjct: 95 TRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGH----------VGASLIVGGVDL 144
Query: 149 KGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
GPQL+ + P G++ + A+GS + A + L++ + +MTL+ A
Sbjct: 145 TGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAA 190
>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
sapiens]
Length = 276
Score = 54.3 bits (129), Expect = 9e-08
Identities = 38/162 (23%), Positives = 77/162 (47%), Gaps = 10/162 (6%)
Query: 34 GSTAIGIQTSEGVCLAVEKRITS-PLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKA 92
G+T + + GV AV+ R ++ + + K++EI+ ++ MSG AD +
Sbjct: 72 GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 131
Query: 93 RVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQ 152
E + ++ E ++V + ++ +SN+ Q+ G+M G D+KGP
Sbjct: 132 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSM---------ICGWDKKGPG 182
Query: 153 LFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
L+++D GT + + + GS + A + Y +++ +EA
Sbjct: 183 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEA 224
>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
sapiens]
Length = 272
Score = 54.3 bits (129), Expect = 9e-08
Identities = 38/162 (23%), Positives = 77/162 (47%), Gaps = 10/162 (6%)
Query: 34 GSTAIGIQTSEGVCLAVEKRITS-PLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKA 92
G+T + + GV AV+ R ++ + + K++EI+ ++ MSG AD +
Sbjct: 68 GTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLL 127
Query: 93 RVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQ 152
E + ++ E ++V + ++ +SN+ Q+ G+M G D+KGP
Sbjct: 128 AKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSM---------ICGWDKKGPG 178
Query: 153 LFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
L+++D GT + + + GS + A + Y +++ +EA
Sbjct: 179 LYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEA 220
>gi|4506203 proteasome beta 7 subunit proprotein [Homo sapiens]
Length = 277
Score = 49.3 bits (116), Expect = 3e-06
Identities = 42/191 (21%), Positives = 77/191 (40%), Gaps = 12/191 (6%)
Query: 32 KLGSTAIGIQTSEGVCLAVEKRITSPLM-EPSSIEKIVEIDAHIGCAMSGLIADAKTLID 90
K G+T G+ +G+ L + R T ++ + KI I +I C +G AD
Sbjct: 41 KTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQ 100
Query: 91 KARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKG 150
+ H + V + + + + ++ G AL+ GGVD G
Sbjct: 101 LISSNLELHSLSTGRLPRVVTANRMLKQMLFRY----------QGYIGAALVLGGVDVTG 150
Query: 151 PQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEAIK-SSLIILKQVMEEK 209
P L+ + P G+ + +GS S A + ++ + M +EA S I + +
Sbjct: 151 PHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDL 210
Query: 210 LNATNIELATV 220
+ +NI+L +
Sbjct: 211 GSGSNIDLCVI 221
>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
Length = 300
Score = 47.0 bits (110), Expect = 1e-05
Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 12/163 (7%)
Query: 34 GSTAIGIQTSEGVCLAVEKRIT--SPLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDK 91
G+T + + GV A + R + S + P+S K++ + H+ SG AD T
Sbjct: 49 GTTTLAFRFRHGVIAAADTRSSCGSYVACPASC-KVIPVHQHLLGTTSGTSADCATWYRV 107
Query: 92 ARVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGP 151
+ E + + +V S + +S + Q+ D VA G D GP
Sbjct: 108 LQRELRLRELREGQLPSVASAAKLLSAMMSQYRGLD---------LCVATALCGWDRSGP 158
Query: 152 QLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
+LF++ GT +Q D ++GS S A L Y M+ +EA
Sbjct: 159 ELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEA 201
>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
Length = 263
Score = 46.6 bits (109), Expect = 2e-05
Identities = 33/162 (20%), Positives = 74/162 (45%), Gaps = 10/162 (6%)
Query: 34 GSTAIGIQTSEGVCLAVEKRITS-PLMEPSSIEKIVEIDAHIGCAMSGLIADAKTLIDKA 92
G+T + + GV +A + R T+ + +++K++EI+ ++ M+G AD
Sbjct: 59 GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118
Query: 93 RVETQNHWFTYNETMTVESVTQAVSNLALQFGEEDADPGAMSRPFGVALLFGGVDEKGPQ 152
+ + + E ++V + ++ ++N+ Q+ G M G D++GP
Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTM---------ICGWDKRGPG 169
Query: 153 LFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKEA 194
L+++D G + ++GS S A + Y + +++A
Sbjct: 170 LYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQA 211
>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 42.0 bits (97), Expect = 5e-04
Identities = 23/92 (25%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGS-TAIGIQTSEGVCLAVEKRITSPLMEPSSIEK 66
+DR + FSP+ +L+QV+YA +AI G T++ ++ + + K + L++ S
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SRTH 150
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQN 98
+ ++ + G ++G+ AD+++ +A+ + N
Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAAN 182
>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 42.0 bits (97), Expect = 5e-04
Identities = 23/92 (25%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGS-TAIGIQTSEGVCLAVEKRITSPLMEPSSIEK 66
+DR + FSP+ +L+QV+YA +AI G T++ ++ + + K + L++ S
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SRTH 150
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQN 98
+ ++ + G ++G+ AD+++ +A+ + N
Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAAN 182
>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 42.0 bits (97), Expect = 5e-04
Identities = 23/92 (25%), Positives = 52/92 (56%), Gaps = 3/92 (3%)
Query: 8 YDRGVNTFSPEGRLFQVEYAIEAIKLGS-TAIGIQTSEGVCLAVEKRITSPLMEPSSIEK 66
+DR + FSP+ +L+QV+YA +AI G T++ ++ + + K + L++ S
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLD--SRTH 150
Query: 67 IVEIDAHIGCAMSGLIADAKTLIDKARVETQN 98
+ ++ + G ++G+ AD+++ +A+ + N
Sbjct: 151 LFKMTKNTGRVITGVTADSRSREQRAQYKAAN 182
>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
sapiens]
Length = 209
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/97 (22%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 31 IKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI-EKIVEIDAHIGCAMSGLIADAKTLI 89
+ G+T + ++ GV + + R+++ + + +K+ + I CA+SG ADA+ +
Sbjct: 7 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVA 66
Query: 90 DKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEE 126
D A + + H E V + V N++ ++ E+
Sbjct: 67 DMAAYQLELHGIELEEPPLVLAAANVVRNISYKYRED 103
>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
sapiens]
Length = 219
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/97 (22%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 31 IKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSI-EKIVEIDAHIGCAMSGLIADAKTLI 89
+ G+T + ++ GV + + R+++ + + +K+ + I CA+SG ADA+ +
Sbjct: 17 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVA 76
Query: 90 DKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEE 126
D A + + H E V + V N++ ++ E+
Sbjct: 77 DMAAYQLELHGIELEEPPLVLAAANVVRNISYKYRED 113
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 32.0 bits (71), Expect = 0.49
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 126 EDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
E+A A+ G+ +F VD G +L M P GT D + E + E Y
Sbjct: 4206 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT----DLETVKQQIEELKQFKSEAY 4261
Query: 186 HKSMTLKEAIKSSLIILKQVMEE 208
+ + ++ + ++LK+V EE
Sbjct: 4262 QQQIEMERLNHQAELLLKKVTEE 4284
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 32.0 bits (71), Expect = 0.49
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 126 EDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
E+A A+ G+ +F VD G +L M P GT D + E + E Y
Sbjct: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT----DLETVKQQIEELKQFKSEAY 4272
Query: 186 HKSMTLKEAIKSSLIILKQVMEE 208
+ + ++ + ++LK+V EE
Sbjct: 4273 QQQIEMERLNHQAELLLKKVTEE 4295
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 32.0 bits (71), Expect = 0.49
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 126 EDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
E+A A+ G+ +F VD G +L M P GT D + E + E Y
Sbjct: 4355 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT----DLETVKQQIEELKQFKSEAY 4410
Query: 186 HKSMTLKEAIKSSLIILKQVMEE 208
+ + ++ + ++LK+V EE
Sbjct: 4411 QQQIEMERLNHQAELLLKKVTEE 4433
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 32.0 bits (71), Expect = 0.49
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 126 EDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVY 185
E+A A+ G+ +F VD G +L M P GT D + E + E Y
Sbjct: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT----DLETVKQQIEELKQFKSEAY 4232
Query: 186 HKSMTLKEAIKSSLIILKQVMEE 208
+ + ++ + ++LK+V EE
Sbjct: 4233 QQQIEMERLNHQAELLLKKVTEE 4255
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,005,530
Number of Sequences: 37866
Number of extensions: 307628
Number of successful extensions: 839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 769
Number of HSP's gapped (non-prelim): 47
length of query: 241
length of database: 18,247,518
effective HSP length: 99
effective length of query: 142
effective length of database: 14,498,784
effective search space: 2058827328
effective search space used: 2058827328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.