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Search of human proteins with 22779877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22779877 connexin 46 [Homo sapiens]
(435 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22779877 connexin 46 [Homo sapiens] 890 0.0
gi|55953076 connexin 50 [Homo sapiens] 340 1e-93
gi|32483412 connexin 40 [Homo sapiens] 307 1e-83
gi|6631083 connexin 40 [Homo sapiens] 307 1e-83
gi|62865885 connexin 37 [Homo sapiens] 304 9e-83
gi|4504001 connexin 43 [Homo sapiens] 300 2e-81
gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens] 284 1e-76
gi|14211941 gap junction protein, alpha 10 [Homo sapiens] 281 6e-76
gi|122939172 connexin 45 [Homo sapiens] 244 1e-64
gi|69122473 connexin 45 [Homo sapiens] 244 1e-64
gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens] 238 1e-62
gi|42558283 gap junction protein beta 2 [Homo sapiens] 229 3e-60
gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens] 215 7e-56
gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens] 215 7e-56
gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens] 215 7e-56
gi|159032020 gap junction protein, beta 6 [Homo sapiens] 214 9e-56
gi|158966714 gap junction protein, beta 6 [Homo sapiens] 214 9e-56
gi|158966717 gap junction protein, beta 6 [Homo sapiens] 214 9e-56
gi|40254837 gap junction protein, beta 6 [Homo sapiens] 214 9e-56
gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens] 208 9e-54
gi|23397464 gap junction protein, beta 4 [Homo sapiens] 198 9e-51
gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens] 194 1e-49
gi|54607056 connexin 31 [Homo sapiens] 186 5e-47
gi|13128960 connexin 31 [Homo sapiens] 186 5e-47
gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens] 184 2e-46
gi|145699105 connexin40.1 [Homo sapiens] 153 3e-37
gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens] 150 2e-36
gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens] 94 2e-19
gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens] 94 2e-19
gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens] 94 2e-19
>gi|22779877 connexin 46 [Homo sapiens]
Length = 435
Score = 890 bits (2300), Expect = 0.0
Identities = 435/435 (100%), Positives = 435/435 (100%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
Sbjct: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP
Sbjct: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
Query: 121 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 180
SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR
Sbjct: 121 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 180
Query: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP 240
CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP
Sbjct: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP 240
Query: 241 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL 300
DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL
Sbjct: 241 DASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLL 300
Query: 301 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP 360
ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP
Sbjct: 301 ALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSP 360
Query: 361 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA 420
PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA
Sbjct: 361 PLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKA 420
Query: 421 SRASSGRARPEDLAI 435
SRASSGRARPEDLAI
Sbjct: 421 SRASSGRARPEDLAI 435
>gi|55953076 connexin 50 [Homo sapiens]
Length = 433
Score = 340 bits (872), Expect = 1e-93
Identities = 201/445 (45%), Positives = 245/445 (55%), Gaps = 22/445 (4%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDWSFLG +LE EHSTVIG+VWLTVLFIFRIL+LG AAE VWGDEQSDF CNTQQPG
Sbjct: 1 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEE--QLKRE 118
CENVCYD AFPISHIR W LQIIFVSTP+L+Y+GH +H VRMEEK+K RE EE Q
Sbjct: 61 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 120
Query: 119 SPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPL 178
+ P + S + R+ G LLRTY+ +IIFKTLFEVGFI G YFLYGF + PL
Sbjct: 121 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL 180
Query: 179 YRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRL 238
YRC RWPCPN VDCF+SRPTEKTIFI+FML+VA SL LN++E+ HLG K ++ + +
Sbjct: 181 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV 240
Query: 239 GPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFK 298
E P + + + + PL + V +P PA F
Sbjct: 241 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPFN 298
Query: 299 LLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALKAYPAASTPAAPSPVGS 357
E G L G+ L + Q E + PPA + P
Sbjct: 299 --QFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPA----EEGAEPEVGEKKEE 352
Query: 358 SSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PPLP 410
+ E E A P +G G G EE + + + P L
Sbjct: 353 AERLTTEEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELT 409
Query: 411 LGDPGRASKASRASSGRARPEDLAI 435
D S+ S+ASS RAR +DL +
Sbjct: 410 TDDARPLSRLSKASS-RARSDDLTV 433
>gi|32483412 connexin 40 [Homo sapiens]
Length = 358
Score = 307 bits (786), Expect = 1e-83
Identities = 142/236 (60%), Positives = 177/236 (75%), Gaps = 4/236 (1%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDWSFLG LE +HSTV+GKVWLTVLFIFR+LVLG AAE WGDEQ+DF C+T QPG
Sbjct: 1 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
C+NVCYD+AFPISHIR+W LQIIFVSTP+L+Y+GH +H VRM+EK+K RE E +
Sbjct: 61 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 120
Query: 121 SPKEPPQDNPSS----RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK 176
E P + + GR+ + G LL TYV +I+ +T EVGFI GQYF+YG L
Sbjct: 121 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 180
Query: 177 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ 232
L+ C R PCP+ V+C++SRPTEK +FI+FMLAVA SLLL++ E+YHLGWKK++Q
Sbjct: 181 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ 236
>gi|6631083 connexin 40 [Homo sapiens]
Length = 358
Score = 307 bits (786), Expect = 1e-83
Identities = 142/236 (60%), Positives = 177/236 (75%), Gaps = 4/236 (1%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDWSFLG LE +HSTV+GKVWLTVLFIFR+LVLG AAE WGDEQ+DF C+T QPG
Sbjct: 1 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
C+NVCYD+AFPISHIR+W LQIIFVSTP+L+Y+GH +H VRM+EK+K RE E +
Sbjct: 61 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 120
Query: 121 SPKEPPQDNPSS----RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELK 176
E P + + GR+ + G LL TYV +I+ +T EVGFI GQYF+YG L
Sbjct: 121 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 180
Query: 177 PLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ 232
L+ C R PCP+ V+C++SRPTEK +FI+FMLAVA SLLL++ E+YHLGWKK++Q
Sbjct: 181 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ 236
>gi|62865885 connexin 37 [Homo sapiens]
Length = 333
Score = 304 bits (779), Expect = 9e-83
Identities = 172/374 (45%), Positives = 224/374 (59%), Gaps = 62/374 (16%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDW FL +LL+ QEHSTV+GK+WLTVLFIFRIL+LG A E VWGDEQSDF CNT QPG
Sbjct: 1 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
C NVCYD+AFPISHIR+W LQ +FVSTPTL+YLGHV+++ R EE+ +++E E R P
Sbjct: 61 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQKEGE---LRALP 117
Query: 121 SPKEPPQDNPSSRDDR----------GRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFL 170
+ K+P + + +R GR+R+ GAL+ TYV +++ K++ E GF+ GQ+ L
Sbjct: 118 A-KDPQVERALAAVERQMAKISVAEDGRLRIRGALMGTYVASVLCKSVLEAGFLYGQWRL 176
Query: 171 YGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKL 230
YG+ ++P++ C R PCP VDCF+SRPTEKTIFIIFML V SL+LN+LE+ HL + L
Sbjct: 177 YGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRCL 236
Query: 231 KQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGA 290
+G+ +R G DA PP SS P + F P+GQ P +
Sbjct: 237 SRGMRARQGQDA---------PPTQGTSSDPYTDQVFF-------YLPVGQG-----PSS 275
Query: 291 PPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWAN-----QAAERQPPALKAYPA 345
PP YNG L +EQNWAN + A +PP P
Sbjct: 276 PP-------------------CPTYNG---LSSSEQNWANLTTEERLASSRPPLFLDPPP 313
Query: 346 ASTPAAPSPVGSSS 359
+ PS SS+
Sbjct: 314 QNGQKPPSRPSSSA 327
>gi|4504001 connexin 43 [Homo sapiens]
Length = 382
Score = 300 bits (768), Expect = 2e-81
Identities = 175/446 (39%), Positives = 238/446 (53%), Gaps = 75/446 (16%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDWS LG+LL+ Q +ST GKVWL+VLFIFRIL+LG A E WGDEQS F CNTQQPG
Sbjct: 1 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
CENVCYD++FPISH+RFW LQIIFVS PTL+YL HV +++R EEK ++EEE ++ +
Sbjct: 61 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG 120
Query: 121 SPKEPPQDNPSSR------DDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFE 174
+ + ++ G+V+M G LLRTY+ +I+FK++FEV F+ Q+++YGF
Sbjct: 121 VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS 180
Query: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV 234
L +Y C R PCP+ VDCF+SRPTEKTIFIIFML V+ SL LN++E++++ +K +K V
Sbjct: 181 LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV 240
Query: 235 TSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPY-----YAHTAAPLGQARAVGYPG 289
G +DP + PA G Y + APL GY
Sbjct: 241 K------------GKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGY-- 286
Query: 290 APPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTP 349
L S + YN +EQNWAN +AE+ +++
Sbjct: 287 -----------KLVTGDRNNSSCRNYNKQ----ASEQNWANYSAEQNRMGQAGSTISNSH 331
Query: 350 AAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPL 409
A P P++ + + AA PL
Sbjct: 332 AQPFDF-----------------------------------PDDNQNSKKLAAGHELQPL 356
Query: 410 PLGDPGRASKASRASSGRARPEDLAI 435
+ D +S+AS +S R RP+DL I
Sbjct: 357 AIVDQRPSSRASSRASSRPRPDDLEI 382
>gi|31542845 gap junction protein, alpha 9, 59kDa [Homo sapiens]
Length = 515
Score = 284 bits (726), Expect = 1e-76
Identities = 132/242 (54%), Positives = 180/242 (74%), Gaps = 8/242 (3%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDW+ LG LE HST+IGK+WLT+LFIFR+LVLG AAEDVW DEQS F CNT+QPG
Sbjct: 1 MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKE------REEEEQ 114
C NVCYD+AFPIS IR+W LQ+IFVS+P+L+Y+GH L+ +R+ E++++ R E E+
Sbjct: 61 CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEE 120
Query: 115 LKRESPSPKEPPQDNPSSRDDR--GRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYG 172
++ E P + + + R + + G LL TYV +I +++ EVGF+ GQY LYG
Sbjct: 121 VEFEMPRDRRRLEQELCQLEKRKLNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLYG 180
Query: 173 FELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ 232
F L+PL++C PCPN +DCF+SRPTEKTIF++FM ++A SL LN+LEI+HLG+KK+K+
Sbjct: 181 FHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIKR 240
Query: 233 GV 234
G+
Sbjct: 241 GL 242
>gi|14211941 gap junction protein, alpha 10 [Homo sapiens]
Length = 543
Score = 281 bits (720), Expect = 6e-76
Identities = 135/259 (52%), Positives = 184/259 (71%), Gaps = 14/259 (5%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MGDW+ LG +LE HST++GK+WLT+LFIFR+LVL AAEDVW DEQS F CNT+QPG
Sbjct: 1 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
C N+CYD AFPIS IRFW LQIIFVS+P+L+Y+GH L+ +R EK ++R ++ L+ +
Sbjct: 61 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQR-KKSHLRAQME 119
Query: 121 SPKEPPQDNPSSRDDR-----------GRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYF 169
+P ++ R DR +V + G LLRTYV +I+ +++ EVGF+ GQY
Sbjct: 120 NPDLDLEE--QQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI 177
Query: 170 LYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKK 229
LYGF++ PLY+C + PCPN VDCF+SRPTEKTIF++FM ++A SLLLN+LEI+HLG +K
Sbjct: 178 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK 237
Query: 230 LKQGVTSRLGPDASEAPLG 248
+ + + + + E G
Sbjct: 238 IMRTLYKKSSSEGIEDETG 256
>gi|122939172 connexin 45 [Homo sapiens]
Length = 396
Score = 244 bits (622), Expect = 1e-64
Identities = 131/289 (45%), Positives = 172/289 (59%), Gaps = 38/289 (13%)
Query: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
Query: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKER--------- 109
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R
Sbjct: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
Query: 110 -----EEEEQLKRESP------------SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFN 152
EE E+ E P KE Q P D R R+R G L++ YV
Sbjct: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKP-KHDGRRRIREDG-LMKIYVLQ 180
Query: 153 IIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVAC 212
++ +T+FEVGF+ GQYFLYGF++ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 213 ASLLLNMLEIYHLGWKKLKQGVTSRL----GPDASEAPLGTADPPPLPP 257
LLLN+ E+ HLG+ ++ + S+ P A P T + P PP
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPP 288
>gi|69122473 connexin 45 [Homo sapiens]
Length = 396
Score = 244 bits (622), Expect = 1e-64
Identities = 131/289 (45%), Positives = 172/289 (59%), Gaps = 38/289 (13%)
Query: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
WSFL RLLE HST +GK+WLTVL +FRI++ E ++ DEQS F CNT+QPGCEN
Sbjct: 3 WSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCEN 62
Query: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLH-IVRME----EKKKER--------- 109
VCYD P+SH+RFW QII V+TP+++YLG+ +H I +ME +KK R
Sbjct: 63 VCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWK 122
Query: 110 -----EEEEQLKRESP------------SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFN 152
EE E+ E P KE Q P D R R+R G L++ YV
Sbjct: 123 QHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKP-KHDGRRRIREDG-LMKIYVLQ 180
Query: 153 IIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVAC 212
++ +T+FEVGF+ GQYFLYGF++ P Y C R PCP+ +DCFISRPTEKTIF++ M V
Sbjct: 181 LLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTG 240
Query: 213 ASLLLNMLEIYHLGWKKLKQGVTSRL----GPDASEAPLGTADPPPLPP 257
LLLN+ E+ HLG+ ++ + S+ P A P T + P PP
Sbjct: 241 LCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPF-TWNTPSAPP 288
>gi|45439367 gap junction protein, gamma 2, 47kDa [Homo sapiens]
Length = 439
Score = 238 bits (606), Expect = 1e-62
Identities = 162/450 (36%), Positives = 214/450 (47%), Gaps = 91/450 (20%)
Query: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
WSFL RLLE HST +GKVWLTVL +FRI++ E ++ DEQ+ FTCNT+QPGC+N
Sbjct: 6 WSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQPGCDN 65
Query: 64 VCYDRAFPISHIRFWALQIIFVSTPTLI---YLGHVLHIVRMEEKKK------------- 107
VCYD P+SH+RFW QI+ +STP+++ Y H L +E+++
Sbjct: 66 VCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRAPR 125
Query: 108 --------------------------EREEEEQLKRESPSPKEPPQDNPSS--------- 132
E EEEE+ + +E +
Sbjct: 126 AHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTKAVGAD 185
Query: 133 ------------RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 180
D R R++ G L+R YV ++ + FEV F+ GQY LYGFE++P +
Sbjct: 186 GKAAGTPGPTGQHDGRRRIQREG-LMRVYVAQLVARAAFEVAFLVGQYLLYGFEVRPFFP 244
Query: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGP 240
C R PCP+ VDCF+SRPTEKT+F++ M V+C LLLN+ E+ HLG + V R GP
Sbjct: 245 CSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGP 304
Query: 241 DASEAPLGTADPPPLPPSSRPPAVAIGF--PPYYAHTAAPLGQARAVGYPGAPPPAADFK 298
AS AP P P PP PA A G PP Y+ +ARA A+
Sbjct: 305 PAS-APA----PAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARA-----HDQNLANLA 354
Query: 299 LLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPS--PVG 356
L AL + G + + L AA R PP A PA+ T +A S VG
Sbjct: 355 LQALRDGAAAGDRDRDSSPCVGL---------PAASRGPPRAGA-PASRTGSATSAGTVG 404
Query: 357 SSSPPLAHEAEAGAAPLL--LDGSGSSLEG 384
P HE GA P GS SS +G
Sbjct: 405 EQGRPGTHE-RPGAKPRAGSEKGSASSRDG 433
>gi|42558283 gap junction protein beta 2 [Homo sapiens]
Length = 226
Score = 229 bits (585), Expect = 3e-60
Identities = 111/224 (49%), Positives = 151/224 (67%), Gaps = 13/224 (5%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L +L +HST IGK+WLTVLFIFRI++L AA++VWGDEQ+DF CNT QPGC+
Sbjct: 2 DWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCK 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSP 122
NVCYD FPISHIR WALQ+IFVSTP L+ +H+ +KK + + ++K E
Sbjct: 62 NVCYDHYFPISHIRLWALQLIFVSTPALLV---AMHVAYRRHEKKRKFIKGEIKSEFKDI 118
Query: 123 KEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYRC 181
+E +VR+ G+L TY +I F+ +FE F+ Y +Y GF ++ L +C
Sbjct: 119 EEIKTQ---------KVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKC 169
Query: 182 DRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
+ WPCPNTVDCF+SRPTEKT+F +FM+AV+ +LLN+ E+ +L
Sbjct: 170 NAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYL 213
>gi|148233402 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 215 bits (547), Expect = 7e-56
Identities = 108/225 (48%), Positives = 145/225 (64%), Gaps = 16/225 (7%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
+W+ L LL HST IG+VWL+V+FIFRI+VL AAE VWGDE+S F CNT QPGC
Sbjct: 2 NWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCN 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKERE-EEEQLKRESPS 121
+VCYD+ FPISH+R W+LQ+I VSTP L+ HV H +E+K E + L E
Sbjct: 62 SVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVK 121
Query: 122 PKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYR 180
R +V ++G L TYV +++F+ LFE F+ Y LY G+ + L +
Sbjct: 122 --------------RHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVK 167
Query: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
CD +PCPNTVDCF+SRPTEKT+F +FMLA + ++LN+ E+ +L
Sbjct: 168 CDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYL 212
>gi|4504005 gap junction protein, beta 1, 32kDa [Homo sapiens]
Length = 283
Score = 215 bits (547), Expect = 7e-56
Identities = 108/225 (48%), Positives = 145/225 (64%), Gaps = 16/225 (7%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
+W+ L LL HST IG+VWL+V+FIFRI+VL AAE VWGDE+S F CNT QPGC
Sbjct: 2 NWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCN 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKERE-EEEQLKRESPS 121
+VCYD+ FPISH+R W+LQ+I VSTP L+ HV H +E+K E + L E
Sbjct: 62 SVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVK 121
Query: 122 PKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYR 180
R +V ++G L TYV +++F+ LFE F+ Y LY G+ + L +
Sbjct: 122 --------------RHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVK 167
Query: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
CD +PCPNTVDCF+SRPTEKT+F +FMLA + ++LN+ E+ +L
Sbjct: 168 CDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYL 212
>gi|10190698 gap junction protein, delta 2, 36kDa [Homo sapiens]
Length = 321
Score = 215 bits (547), Expect = 7e-56
Identities = 112/284 (39%), Positives = 164/284 (57%), Gaps = 50/284 (17%)
Query: 1 MGDWSFLGRLLENA-QEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQP 59
MG+W+ L RLLE A Q+HST+IG++ LTV+ IFRIL++ E V+ DEQ+ F CNT QP
Sbjct: 1 MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGETVYDDEQTMFVCNTLQP 60
Query: 60 GCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKK--------EREE 111
GC CYDRAFPISHIR+W QII V TP+L ++ + +H + +++ +R+
Sbjct: 61 GCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSAKQRERRYSTVFLALDRDP 120
Query: 112 EEQL--------------KRESP----------------SPKEPPQD---------NPSS 132
E + KRE + KE D +PS
Sbjct: 121 PESIGGPGGTGGGGSGGGKREDKKLQNAIVNGVLQNTENTSKETEPDCLEVKELTPHPSG 180
Query: 133 --RDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTV 190
+ ++R + R Y+ ++F+ E+GF+ GQYFLYGF + LY C+R+PC V
Sbjct: 181 LRTASKSKLRRQEGISRFYIIQVVFRNALEIGFLVGQYFLYGFSVPGLYECNRYPCIKEV 240
Query: 191 DCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV 234
+C++SRPTEKT+F++FM AV+ ++LN+ E+ HLGW+K+K V
Sbjct: 241 ECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLGWRKIKLAV 284
>gi|159032020 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 214 bits (546), Expect = 9e-56
Identities = 107/231 (46%), Positives = 146/231 (63%), Gaps = 27/231 (11%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L + +HST IGKVW+TV+FIFR+++L AA++VWGDEQ DF CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-------VRMEEKKKEREEEEQL 115
NVCYD FP+SHIR WALQ+IFVSTP L+ HV + R EK+ + ++ E +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDI 121
Query: 116 KRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFE 174
K++ +VR+ G+L TY +I F+ +FE F+ YFLY G+
Sbjct: 122 KKQ-------------------KVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYH 162
Query: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
L + +C PCPN VDCFISRPTEKT+F IFM++ + +LLN+ E+ +L
Sbjct: 163 LPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|158966714 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 214 bits (546), Expect = 9e-56
Identities = 107/231 (46%), Positives = 146/231 (63%), Gaps = 27/231 (11%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L + +HST IGKVW+TV+FIFR+++L AA++VWGDEQ DF CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-------VRMEEKKKEREEEEQL 115
NVCYD FP+SHIR WALQ+IFVSTP L+ HV + R EK+ + ++ E +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDI 121
Query: 116 KRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFE 174
K++ +VR+ G+L TY +I F+ +FE F+ YFLY G+
Sbjct: 122 KKQ-------------------KVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYH 162
Query: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
L + +C PCPN VDCFISRPTEKT+F IFM++ + +LLN+ E+ +L
Sbjct: 163 LPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|158966717 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 214 bits (546), Expect = 9e-56
Identities = 107/231 (46%), Positives = 146/231 (63%), Gaps = 27/231 (11%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L + +HST IGKVW+TV+FIFR+++L AA++VWGDEQ DF CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-------VRMEEKKKEREEEEQL 115
NVCYD FP+SHIR WALQ+IFVSTP L+ HV + R EK+ + ++ E +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDI 121
Query: 116 KRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFE 174
K++ +VR+ G+L TY +I F+ +FE F+ YFLY G+
Sbjct: 122 KKQ-------------------KVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYH 162
Query: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
L + +C PCPN VDCFISRPTEKT+F IFM++ + +LLN+ E+ +L
Sbjct: 163 LPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|40254837 gap junction protein, beta 6 [Homo sapiens]
Length = 261
Score = 214 bits (546), Expect = 9e-56
Identities = 107/231 (46%), Positives = 146/231 (63%), Gaps = 27/231 (11%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L + +HST IGKVW+TV+FIFR+++L AA++VWGDEQ DF CNT QPGC+
Sbjct: 2 DWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCK 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHI-------VRMEEKKKEREEEEQL 115
NVCYD FP+SHIR WALQ+IFVSTP L+ HV + R EK+ + ++ E +
Sbjct: 62 NVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDI 121
Query: 116 KRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFE 174
K++ +VR+ G+L TY +I F+ +FE F+ YFLY G+
Sbjct: 122 KKQ-------------------KVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYH 162
Query: 175 LKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
L + +C PCPN VDCFISRPTEKT+F IFM++ + +LLN+ E+ +L
Sbjct: 163 LPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYL 213
>gi|148839378 gap junction protein, delta 3, 31.9kDa [Homo sapiens]
Length = 294
Score = 208 bits (529), Expect = 9e-54
Identities = 120/308 (38%), Positives = 162/308 (52%), Gaps = 20/308 (6%)
Query: 1 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 60
MG+W+FLG LL+ Q S ++G++WL V+ IFRILVL V+ DEQ +F CNT QPG
Sbjct: 1 MGEWAFLGSLLDAVQLQSPLVGRLWLVVMLIFRILVLATVGGAVFEDEQEEFVCNTLQPG 60
Query: 61 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 120
C CYDRAFP+SH RFW I+ +S P ++++ + +H KE E + +P
Sbjct: 61 CRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVVYSMH-----RAGKEAGGAEAAAQCAP 115
Query: 121 SPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYR 180
E + R R R R Y+ ++ + L E+ F+ GQ LYGF + P +
Sbjct: 116 GLPEAQCAPCALRARRAR--------RCYLLSVALRLLAELTFLGGQALLYGFRVAPHFA 167
Query: 181 CDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWK-KLKQGVTSRLG 239
C PCP+TVDCF+SRPTEKT+F++F AV S LL++ E+ HL WK + + G
Sbjct: 168 CAGPPCPHTVDCFVSRPTEKTVFVLFYFAVGLLSALLSVAELGHLLWKGRPRAGERDNRC 227
Query: 240 PDASEAPLGTADPPPLPP-----SSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPA 294
A E PPP PP SR P PP YAH AP G PA
Sbjct: 228 NRAHEEAQKLLPPPPPPPPPPALPSRRPGPEPCAPPAYAH-PAPASLRECGSGRGKASPA 286
Query: 295 ADFKLLAL 302
+ LA+
Sbjct: 287 TGRRDLAI 294
>gi|23397464 gap junction protein, beta 4 [Homo sapiens]
Length = 266
Score = 198 bits (503), Expect = 9e-51
Identities = 99/228 (43%), Positives = 144/228 (63%), Gaps = 18/228 (7%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
+W+FL LL ++STV+ ++WL+V+FIFR+LV AAE+VW DEQ DF CNT+QPGC
Sbjct: 2 NWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPGCP 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSP 122
NVCYD FP+SH+R WALQ+I V+ P+L+ + HV + ++ERE + LK +P
Sbjct: 62 NVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAY-------REERERKHHLKHGPNAP 114
Query: 123 KEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYRC 181
DN S + G L TY+ ++IFK + GF+ + LY +++ + C
Sbjct: 115 S--LYDNLSKK--------RGGLWWTYLLSLIFKAAVDAGFLYIFHRLYKDYDMPRVVAC 164
Query: 182 DRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKK 229
PCP+TVDC+ISRPTEK +F FM+ A +LLN+ E+++L K+
Sbjct: 165 SVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKR 212
>gi|38348412 gap junction protein, beta 7, 25kDa [Homo sapiens]
Length = 223
Score = 194 bits (493), Expect = 1e-49
Identities = 100/223 (44%), Positives = 139/223 (62%), Gaps = 25/223 (11%)
Query: 4 WSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCEN 63
W FL LL ++ST G +WL V+F+FR+LV AAE VW DEQ +F CN++QPGC+N
Sbjct: 3 WMFLRDLLSGVNKYSTGTGWIWLAVVFVFRLLVYMVAAEHVWKDEQKEFECNSRQPGCKN 62
Query: 64 VCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPK 123
VC+D FPIS +R WALQ+I VSTP+L+ VLH+ E ++K ++ +
Sbjct: 63 VCFDDFFPISQVRLWALQLIMVSTPSLLV---VLHVAYHEGREKRHRKKLYV-------- 111
Query: 124 EPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYRCD 182
+P + D G L Y+ ++I KT FE+GF+ Y LY GF + L +CD
Sbjct: 112 -----SPGTMD--------GGLWYAYLISLIVKTGFEIGFLVLFYKLYDGFSVPYLIKCD 158
Query: 183 RWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHL 225
PCPNTVDCFIS+PTEKTIFI+F++ +C ++LN +E+ L
Sbjct: 159 LKPCPNTVDCFISKPTEKTIFILFLVITSCLCIVLNFIELSFL 201
>gi|54607056 connexin 31 [Homo sapiens]
Length = 270
Score = 186 bits (471), Expect = 5e-47
Identities = 99/234 (42%), Positives = 142/234 (60%), Gaps = 19/234 (8%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L LL ++ST G++WL+V+F+FR+LV AAE VWGDEQ DF CNT+QPGC
Sbjct: 2 DWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCT 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSP 122
NVCYD FPIS+IR WALQ+IFV+ P+L+ + HV + ++ERE + K
Sbjct: 62 NVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAY-------REERERRHRQKHGDQCA 114
Query: 123 KEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFL-YGFELKPLYRC 181
K DN + G L TY+F++IFK + E F+ + L +GF + L +C
Sbjct: 115 K--LYDNAGKKH--------GGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQC 164
Query: 182 -DRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV 234
+ PCPN VDC+I+RPTEK IF FM+ + ++L + E+ +L ++ +G+
Sbjct: 165 ANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGL 218
>gi|13128960 connexin 31 [Homo sapiens]
Length = 270
Score = 186 bits (471), Expect = 5e-47
Identities = 99/234 (42%), Positives = 142/234 (60%), Gaps = 19/234 (8%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
DW L LL ++ST G++WL+V+F+FR+LV AAE VWGDEQ DF CNT+QPGC
Sbjct: 2 DWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCT 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSP 122
NVCYD FPIS+IR WALQ+IFV+ P+L+ + HV + ++ERE + K
Sbjct: 62 NVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAY-------REERERRHRQKHGDQCA 114
Query: 123 KEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFL-YGFELKPLYRC 181
K DN + G L TY+F++IFK + E F+ + L +GF + L +C
Sbjct: 115 K--LYDNAGKKH--------GGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQC 164
Query: 182 -DRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGV 234
+ PCPN VDC+I+RPTEK IF FM+ + ++L + E+ +L ++ +G+
Sbjct: 165 ANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGL 218
>gi|10835079 gap junction protein, beta 5, 31.1kDa [Homo sapiens]
Length = 273
Score = 184 bits (466), Expect = 2e-46
Identities = 93/236 (39%), Positives = 140/236 (59%), Gaps = 18/236 (7%)
Query: 3 DWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCE 62
+WS LL ++ST G++WL+++FIFR+LV AE VW D+ DF CNT+QPGC
Sbjct: 2 NWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCS 61
Query: 63 NVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSP 122
NVC+D FP+SH+R WALQ+I V+ P+L+ + HV + RE +E+ RE+
Sbjct: 62 NVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAY----------REVQEKRHREA--- 108
Query: 123 KEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLY-GFELKPLYRC 181
S R + G L TYV +++FK ++ F+ + Y + L P+ +C
Sbjct: 109 ----HGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKC 164
Query: 182 DRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR 237
PCPN VDCFIS+P+EK IF +FM+A A +LLN++E+ +L K+ + + +R
Sbjct: 165 HADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAAR 220
>gi|145699105 connexin40.1 [Homo sapiens]
Length = 370
Score = 153 bits (386), Expect = 3e-37
Identities = 112/373 (30%), Positives = 167/373 (44%), Gaps = 44/373 (11%)
Query: 7 LGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCY 66
LG L+ + T++GK+W + + R+LV+ A V+ DEQ F CNT QPGC NVCY
Sbjct: 7 LGFLIITLNCNVTMVGKLWFVLTMLLRMLVIVLAGRPVYQDEQERFVCNTLQPGCANVCY 66
Query: 67 DRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPP 126
D P+SH+RFW +Q + V P+ ++ +VLH + R P P+EP
Sbjct: 67 DVFSPVSHLRFWLIQGVCVLLPSAVFSVYVLH--------RGATLAALGPRRCPDPREPA 118
Query: 127 QDN---PSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDR 183
P +RG +++ Y+ +++ +TL E F A YFL+GF + C R
Sbjct: 119 SGQRRCPRPFGERGGLQVPD-FSAGYIIHLLLRTLLEAAFGALHYFLFGFLAPKKFPCTR 177
Query: 184 WPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDAS 243
PC VDC++SRPTEK++ ++F+ AV+ S LL + ++ L++ + R G
Sbjct: 178 PPCTGVVDCYVSRPTEKSLLMLFLWAVSALSFLLGLADLV----CSLRRRMRRRPG---- 229
Query: 244 EAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALT 303
PP PS R + A G G G P APP A A
Sbjct: 230 ---------PPTSPSIRKQSGASGHAE--GRRTDEEGGREEEGAP-APPGAR-----AGG 272
Query: 304 EARGKGQSAKLYNGHHHLLMTEQNWANQAAE----RQPPALKAYPAASTPAAPSPVGSSS 359
E G + +GH + +++ +A RQP + P P GS
Sbjct: 273 EGAGSPRRTSRVSGHTKIPDEDESEVTSSASEKLGRQP---RGRPHREAAQDPRGSGSEE 329
Query: 360 PPLAHEAEAGAAP 372
P A + A P
Sbjct: 330 QPSAAPSRLAAPP 342
Score = 28.9 bits (63), Expect = 9.6
Identities = 25/79 (31%), Positives = 38/79 (48%), Gaps = 12/79 (15%)
Query: 356 GSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAG---TPEEEEQAVTTAAQMHQPPLPLG 412
G+ +PP A AG +G+GS S ++G P+E+E VT++A P G
Sbjct: 261 GAPAPP---GARAGG-----EGAGSPRRTSRVSGHTKIPDEDESEVTSSASEKLGRQPRG 312
Query: 413 DPGR-ASKASRASSGRARP 430
P R A++ R S +P
Sbjct: 313 RPHREAAQDPRGSGSEEQP 331
>gi|31559821 gap junction protein, gamma 3, 30.2kDa [Homo sapiens]
Length = 279
Score = 150 bits (380), Expect = 2e-36
Identities = 89/236 (37%), Positives = 132/236 (55%), Gaps = 17/236 (7%)
Query: 6 FLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVC 65
FL RLL ST +G++ L VL FR+++L A+ V+GDEQS+F C+TQQPGC+ C
Sbjct: 5 FLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAAC 64
Query: 66 YDRAFPISHIRFWALQIIFVSTPTLIYLGHVL-HIVRMEEKKKEREEEEQLKRESPSPKE 124
+D P+S +RFW Q+I V+ P+ +Y+G L H++ E + +EEE L + +E
Sbjct: 65 FDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIWHWELSGKGKEEETLIQ----GRE 120
Query: 125 PPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRW 184
D P + G +R LL YV + + + E + QY LYGF++ + C R
Sbjct: 121 GNTDVPGA----GSLR----LLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACRRE 172
Query: 185 PCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLG----WKKLKQGVTS 236
PC ++ C +SRP+EKTIF+ M V+ LL LE+ LG W+ K +S
Sbjct: 173 PCLGSITCNLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGLGRWWRTWKHKSSS 228
>gi|169171704 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 94.4 bits (233), Expect = 2e-19
Identities = 39/86 (45%), Positives = 60/86 (69%)
Query: 10 LLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRA 69
LL HST +G++ VL FR+++L A+ V+GDEQS+F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHIRFWALQIIFVSTPTLIYLGH 95
P+S +RFW Q+I V+ P+++Y+G+
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171845 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 94.4 bits (233), Expect = 2e-19
Identities = 39/86 (45%), Positives = 60/86 (69%)
Query: 10 LLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRA 69
LL HST +G++ VL FR+++L A+ V+GDEQS+F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHIRFWALQIIFVSTPTLIYLGH 95
P+S +RFW Q+I V+ P+++Y+G+
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
>gi|169171183 PREDICTED: similar to hCG1770601 [Homo sapiens]
Length = 222
Score = 94.4 bits (233), Expect = 2e-19
Identities = 39/86 (45%), Positives = 60/86 (69%)
Query: 10 LLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRA 69
LL HST +G++ VL FR+++L A+ V+GDEQS+F C+TQQPGC+ C+D
Sbjct: 28 LLAEESWHSTPVGRLLFPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGCKAACFDAF 87
Query: 70 FPISHIRFWALQIIFVSTPTLIYLGH 95
P+S +RFW Q+I V+ P+++Y+G+
Sbjct: 88 HPLSPLRFWVFQVILVAVPSVLYMGY 113
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,475,848
Number of Sequences: 37866
Number of extensions: 1143136
Number of successful extensions: 15266
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 564
Number of HSP's that attempted gapping in prelim test: 12339
Number of HSP's gapped (non-prelim): 3119
length of query: 435
length of database: 18,247,518
effective HSP length: 105
effective length of query: 330
effective length of database: 14,271,588
effective search space: 4709624040
effective search space used: 4709624040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.