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Search of human proteins with 22035679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035679 AT rich interactive domain 4B isoform 2 [Homo
sapiens]
(1226 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens] 2425 0.0
gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens] 2327 0.0
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 813 0.0
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 742 0.0
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 689 0.0
gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo sapi... 92 4e-18
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 88 4e-17
gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo s... 86 2e-16
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 82 2e-15
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 82 2e-15
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 82 3e-15
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 82 3e-15
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 80 2e-14
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 79 3e-14
gi|47078224 AT rich interactive domain 5A [Homo sapiens] 77 1e-13
gi|5453638 AT rich interactive domain 3B [Homo sapiens] 76 2e-13
gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein ... 72 3e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 70 2e-11
gi|87299628 biorientation of chromosomes in cell division 1-like... 66 2e-10
gi|221219020 NYD-SP11 protein [Homo sapiens] 65 4e-10
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 65 4e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 4e-10
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ... 65 4e-10
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ... 65 4e-10
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 64 1e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 64 1e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 63 2e-09
gi|104526627 triadin [Homo sapiens] 63 2e-09
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 63 2e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 62 3e-09
>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
Length = 1226
Score = 2425 bits (6284), Expect = 0.0
Identities = 1226/1226 (100%), Positives = 1226/1226 (100%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
Query: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK
Sbjct: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
Query: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE
Sbjct: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
Query: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA
Sbjct: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
Query: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC
Sbjct: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP
Sbjct: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
Query: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVR 540
THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVR
Sbjct: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVR 540
Query: 541 PADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTD 600
PADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTD
Sbjct: 541 PADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTD 600
Query: 601 AKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRN 660
AKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRN
Sbjct: 601 AKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRN 660
Query: 661 DLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKD 720
DLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKD
Sbjct: 661 DLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKD 720
Query: 721 VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE 780
VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE
Sbjct: 721 VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE 780
Query: 781 EETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKD 840
EETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKD
Sbjct: 781 EETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKD 840
Query: 841 VWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEK 900
VWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEK
Sbjct: 841 VWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEK 900
Query: 901 PPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVT 960
PPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVT
Sbjct: 901 PPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVT 960
Query: 961 VSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP 1020
VSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP
Sbjct: 961 VSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP 1020
Query: 1021 EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITK 1080
EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITK
Sbjct: 1021 EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITK 1080
Query: 1081 SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN 1140
SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN
Sbjct: 1081 SQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLEN 1140
Query: 1141 MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI 1200
MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI
Sbjct: 1141 MTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSI 1200
Query: 1201 TAAVMLTLAEPSMSSASQNGMSVECR 1226
TAAVMLTLAEPSMSSASQNGMSVECR
Sbjct: 1201 TAAVMLTLAEPSMSSASQNGMSVECR 1226
>gi|22035677 AT rich interactive domain 4B isoform 1 [Homo sapiens]
Length = 1312
Score = 2327 bits (6031), Expect = 0.0
Identities = 1199/1312 (91%), Positives = 1209/1312 (92%), Gaps = 86/1312 (6%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL
Sbjct: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL
Sbjct: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD
Sbjct: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVD 180
Query: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK
Sbjct: 181 YISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPK 240
Query: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE
Sbjct: 241 PDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEE 300
Query: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA
Sbjct: 301 EIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGA 360
Query: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC
Sbjct: 361 VWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKEC 420
Query: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP
Sbjct: 421 ENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIP 480
Query: 481 THSDQEKEVNI------------------------------------------------- 491
THSDQEKEVNI
Sbjct: 481 THSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDE 540
Query: 492 ---KKPEDNENLDDKDDDTTRVDESLN-----IKVEAEEEKAKSG--------------- 528
++ E+ E +D+DDD +E +KV+ + K+
Sbjct: 541 EAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGG 600
Query: 529 --------------YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 574
YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC
Sbjct: 601 EVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 660
Query: 575 KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE 634
KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE
Sbjct: 661 KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQE 720
Query: 635 DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE 694
DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE
Sbjct: 721 DERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPE 780
Query: 695 RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG 754
RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG
Sbjct: 781 RLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPG 840
Query: 755 KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE 814
KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE
Sbjct: 841 KKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSE 900
Query: 815 VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP 874
VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP
Sbjct: 901 VAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAP 960
Query: 875 EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL 934
EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL
Sbjct: 961 EEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVL 1020
Query: 935 NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD 994
NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD
Sbjct: 1021 NTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD 1080
Query: 995 LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1054
LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV
Sbjct: 1081 LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1140
Query: 1055 VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK 1114
VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK
Sbjct: 1141 VNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDK 1200
Query: 1115 DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR 1174
DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR
Sbjct: 1201 DPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRR 1260
Query: 1175 RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1226
RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
Sbjct: 1261 RKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1312
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 813 bits (2101), Expect = 0.0
Identities = 556/1341 (41%), Positives = 752/1341 (56%), Gaps = 199/1341 (14%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNI---------------------IPRE 451
V ++ K+ E E +K + E + E+K E E NI I R+
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARD 476
Query: 452 EKPIEDEIER---KENIKPSLGSKKNLLESIPT-------------HSDQEKEVNIKKPE 495
I+ EIE ++ +K + K++ + T ++ ++KE IKK E
Sbjct: 477 VNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQE 536
Query: 496 DNENLDDKDDDTTRVDESLNIKVEAEEE---------------KAKSG------------ 528
D++ D++++ ++ E K ++E E K K G
Sbjct: 537 DSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASI 596
Query: 529 ----------------------YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD 566
YDEW+KAD+I+ P DK PK K +KK KNK D E KD
Sbjct: 597 KSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSE--KD 654
Query: 567 EKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASES 626
EK + K +R +PP ++ S M L T N S+S
Sbjct: 655 EKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSEGKSDS 695
Query: 627 SAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS 686
+ DSE ED E++ I+ + +++L E N L EEN IS
Sbjct: 696 CSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENP-----KIS 740
Query: 687 KPVSKSPERLR-KDIEVLSEDTDYEEDEV------TKKRKDVKKDTTDKSSKPQIKRGKR 739
+ K +R + + +E L + E V +K ++VKK+ +KS K + +R K
Sbjct: 741 AHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKE-AEKSPKGKGRRSKT 799
Query: 740 RYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMTPTK-K 792
+ + E +K S G+ E +A + E ++N + SS+ EDE + K K K
Sbjct: 800 KDLSL-EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRK 858
Query: 793 YNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSIQGQWP 850
G K +R + V+++R S+ + L + +R++
Sbjct: 859 ILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAES 918
Query: 851 KKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSK 909
+ +++L S+ D+ A + P E+ E+++ + E V+L+ D
Sbjct: 919 NQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD--EKDKT 973
Query: 910 PIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQ 969
IE+ VE SS SNS+++ PP P Q + +V+ PL +Q
Sbjct: 974 SIEDVAVE---------SSESNSLVSIPPALPPV-----------VQHNFSVASPLTLSQ 1013
Query: 970 EEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEHPEKAC 1027
+E RS+KSE+D TIEVDS+A E Q+ E S GF+ +V+S + + E E EK
Sbjct: 1014 DESRSVKSESDITIEVDSIAEESQEGLCE-RESANGFETNVASGTCSIIVQERESREK-- 1070
Query: 1028 TGQKRVKDAQGGGSSSKKQKRSHKAT--VVNNKKKGKGTNSSDSEELSAGESITKSQPVK 1085
GQKR D G +KKQKR+ K T N+K G G SSDSE+L ++ +K PVK
Sbjct: 1071 -GQKRPSDG-NSGLMAKKQKRTPKRTSAAAKNEKNGTG-QSSDSEDLPVLDNSSKCTPVK 1127
Query: 1086 SVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAE 1145
++ +SPAR SP K+G+KD ++ N P+ YKWSFQ+++L+NM S E
Sbjct: 1128 HLNVSKPQKLARSPARI-SPHI--KDGEKDKHREKHPNSSPRTYKWSFQLNELDNMNSTE 1184
Query: 1146 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVM 1205
RI+ LQEKLQEIRK+Y+SLKSEVA+IDRRRKRLKKK+RE + +S SS SS
Sbjct: 1185 RISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSD------- 1237
Query: 1206 LTLAEPSMSSASQNGMSVECR 1226
T PS SS QN ++VECR
Sbjct: 1238 -TGMSPSSSSPPQNVLAVECR 1257
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 742 bits (1916), Expect = 0.0
Identities = 528/1339 (39%), Positives = 711/1339 (53%), Gaps = 264/1339 (19%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALP-EKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNI---------------------IPRE 451
V ++ K+ E E +K + E + E+K E E NI I R+
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARD 476
Query: 452 EKPIEDEIERK---ENIKPSLGSKKNLLESIPT-------------HSDQEKEVNIKKPE 495
I+ EIE + + +K + K++ + T ++ ++KE IKK E
Sbjct: 477 VNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQE 536
Query: 496 DNENLDDKDDDTTRVDESLNIKVEAEEE---------------KAKSG------------ 528
D++ D++++ ++ E K ++E E K K G
Sbjct: 537 DSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASI 596
Query: 529 ----------------------YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD 566
YDEW+KAD+I+ P DK PK K +KK KNK D EKD
Sbjct: 597 KSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKD-- 654
Query: 567 EKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASES 626
EK + K +R +PP ++ S M L T N S+S
Sbjct: 655 EKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSEGKSDS 695
Query: 627 SAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS 686
+ DSE ED E++ I+ + +++L E N L EEN IS
Sbjct: 696 CSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENPK-----IS 740
Query: 687 KPVSKSPERLR-KDIEVLSEDTDYEEDEVT------KKRKDVKKDTTDKSSKPQIKRGKR 739
+ K +R + + +E L + E V +K ++VKK+ +KS K + +R K
Sbjct: 741 AHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEA-EKSPKGKGRRSKT 799
Query: 740 RYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMTPTK-K 792
+ + E +K S G+ E +A + E ++N + SS+ EDE + K K K
Sbjct: 800 KDLSLE-IIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRK 858
Query: 793 YNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSIQGQWP 850
G K +R + V+++R S+ + L + +R++
Sbjct: 859 ILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAES 918
Query: 851 KKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSK 909
+ +++L S+ D+ A + P E+ E+++ + E V+L+ D
Sbjct: 919 NQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD--EKDKT 973
Query: 910 PIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQ 969
IE+ VE SS SNS+++ PP P Q + +V+ PL +Q
Sbjct: 974 SIEDVAVE---------SSESNSLVSIPPALPPVV-----------QHNFSVASPLTLSQ 1013
Query: 970 EEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEHPEKAC 1027
+E RS+KSE+D TIEVDS+A E Q+ E S+ GF+ +V+S + + E E EK
Sbjct: 1014 DESRSVKSESDITIEVDSIAEESQEGLCERESAN-GFETNVASGTCSIIVQERESREK-- 1070
Query: 1028 TGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSV 1087
GQKR D G +KKQK
Sbjct: 1071 -GQKRPSDGNSG-LMAKKQK---------------------------------------- 1088
Query: 1088 STGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERI 1147
++P RT + K KNG +L+NM S ERI
Sbjct: 1089 ---------RTPKRTSAAAKNEKNGT----------------------DELDNMNSTERI 1117
Query: 1148 TILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLT 1207
+ LQEKLQEIRK+Y+SLKSEVA+IDRRRKRLKKK+RE + +S SS SS T
Sbjct: 1118 SFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSD--------T 1169
Query: 1208 LAEPSMSSASQNGMSVECR 1226
PS SS QN ++VECR
Sbjct: 1170 GMSPSSSSPPQNVLAVECR 1188
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 689 bits (1778), Expect = 0.0
Identities = 506/1341 (37%), Positives = 698/1341 (52%), Gaps = 253/1341 (18%)
Query: 1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPL 60
MKA DEP YLTVGTDVSAKYRGAFCEAKIKT KRLVKVKV + D++T VQDD +KGPL
Sbjct: 1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGPL 60
Query: 61 KVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETL 120
+VGAIVE + DG++QEA+I+KLTDASWYTVVFDDGDE+TLRR+SLCLKGERHFAESETL
Sbjct: 61 RVGAIVETRTSDGSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETL 120
Query: 121 DQLPLTNPEHFGTPVIGKKTNRGRRSNHIP---EEESSSSSSDEDEDDRKQIDELLGKVV 177
DQLPLTNPEHFGTPVI KKTNRGRRS+ +P +E+ SS +EDED R+ DELLGKVV
Sbjct: 121 DQLPLTNPEHFGTPVIAKKTNRGRRSS-LPVTEDEKEEESSEEEDEDKRRLNDELLGKVV 179
Query: 178 CVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDT 237
V + ++ W+PALV+ P C+D+I VKKD LVRSF D KF S+ RKD+ E+
Sbjct: 180 SVVSAT---ERTEWYPALVISPSCNDDITVKKDQCLVRSFIDSKFYSIARKDIKEVDILN 236
Query: 238 APKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEE---EEEDDEKEKEDN 294
P+ + K ++A F K+R +P NWK ++ E SS +++E+ EE D+EKEKE
Sbjct: 237 LPESELSTKPGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAK 296
Query: 295 SSEEE-EEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGF 353
+EEE E E PEER+NFLQQLYKFMEDRGTPINK PVLGY++LNLFKLFRLV+ GG
Sbjct: 297 KTEEEVPEEELDPEERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGC 356
Query: 354 DNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQ-MALPEKV 412
DNI+SGAVWKQ+Y DLGIP+LNSAA YNVK AY+KYLYGFEEYCRSANI+F+ + E
Sbjct: 357 DNIDSGAVWKQIYMDLGIPILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPK 416
Query: 413 VNKQCKECENVKEIKVKEENETEIKEIKMEEERNI---------------------IPRE 451
V ++ K+ E E +K + E + E+K E E NI I R+
Sbjct: 417 VKEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPRGRRRIARD 476
Query: 452 EKPIEDEIER---KENIKPSLGSKKNLLESIPT-------------HSDQEKEVNIKKPE 495
I+ EIE ++ +K + K++ + T ++ ++KE IKK E
Sbjct: 477 VNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKKIKKQE 536
Query: 496 DNENLDDKDDDTTRVDESLNIKVEAEEE---------------KAKSG------------ 528
D++ D++++ ++ E K ++E E K K G
Sbjct: 537 DSDKDSDEEEEKSQEREETESKCDSEGEEDEEDMEPCLTGTKVKVKYGRGKTQKIYEASI 596
Query: 529 ----------------------YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD 566
YDEW+KAD+I+ P DK PK K +KK KNK D E KD
Sbjct: 597 KSTEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSE--KD 654
Query: 567 EKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASES 626
EK + K +R +PP ++ S M L T N S+S
Sbjct: 655 EKRDEERQKSKR-GRPPLKSTLSSNMPYGLSKT------------------ANSEGKSDS 695
Query: 627 SAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS 686
+ DSE ED E++ I+ + +++L E N L EEN IS
Sbjct: 696 CSSDSETED----------ALEKNLINEELSLKDELEKNENLNDDKLDEENP-----KIS 740
Query: 687 KPVSKSPERLR-KDIEVLSEDTDYEEDEV------TKKRKDVKKDTTDKSSKPQIKRGKR 739
+ K +R + + +E L + E V +K ++VKK+ +KS K + +R K
Sbjct: 741 AHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKE-AEKSPKGKGRRSKT 799
Query: 740 RYCNTEECLKTGSPGKKEE------KAKNKESLCMENSSNSSSDEDEEETKAKMTPTK-K 792
+ + E +K S G+ E +A + E ++N + SS+ EDE + K K K
Sbjct: 800 KDLSL-EIIKISSFGQNEAGSEPHIEAHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRK 858
Query: 793 YNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSD--ERLQNSRAKDRKDVWSSIQGQWP 850
G K +R + V+++R S+ + L + +R++
Sbjct: 859 ILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAES 918
Query: 851 KKTLKELFSDS-DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSK 909
+ +++L S+ D+ A + P E+ E+++ + E V+L+ D
Sbjct: 919 NQCIQQLTSERFDSPAEETVNIPLKED---EDAMPLIGPETLVCHEVDLDDLD--EKDKT 973
Query: 910 PIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQ 969
IE+ VE SS SNS+++ PP P Q + +V+ PL +Q
Sbjct: 974 SIEDVAVE---------SSESNSLVSIPPALPPV-----------VQHNFSVASPLTLSQ 1013
Query: 970 EEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSN--QPEPEHPEKAC 1027
+E RS+KSE+D TIEVDS+A E Q+ E S GF+ +V+S + + E E EK
Sbjct: 1014 DESRSVKSESDITIEVDSIAEESQEGLCE-RESANGFETNVASGTCSIIVQERESREK-- 1070
Query: 1028 TGQKRVKDAQGGGSSSKKQKRSHKAT--VVNNKKKGKGTNSSDSEELSAGESITKSQPVK 1085
GQKR D G +KKQKR+ K T N+K G G SSDSE+L ++ + +
Sbjct: 1071 -GQKRPSDG-NSGLMAKKQKRTPKRTSAAAKNEKNGTG-QSSDSEDLPVLDNSNELDNMN 1127
Query: 1086 SVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAE 1145
S ++ L+E + K Y M+
Sbjct: 1128 ST-------------------------ERISFLQEKLQEIRKYY-----------MSLKS 1151
Query: 1146 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVM 1205
+ + + + ++K K+RE + +S SS SS
Sbjct: 1152 EVATIDRRRKRLKK---------------------KDREVSHAGASMSSASSD------- 1183
Query: 1206 LTLAEPSMSSASQNGMSVECR 1226
T PS SS QN ++VECR
Sbjct: 1184 -TGMSPSSSSPPQNVLAVECR 1203
>gi|74136549 AT rich interactive domain 5B (MRF1-like) [Homo
sapiens]
Length = 1188
Score = 91.7 bits (226), Expect = 4e-18
Identities = 60/237 (25%), Positives = 123/237 (51%), Gaps = 12/237 (5%)
Query: 295 SSEEEEEI---EPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLG 351
S+EE+ ++ E + + FL LYK+M++R TPI + P LG++ +NL+ +F+ KLG
Sbjct: 304 SNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLG 363
Query: 352 GFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEK 411
G++ I + WK +Y +LG +++A + Y++ + +E + + + + +
Sbjct: 364 GYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPR 423
Query: 412 VVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGS 471
+E EN ++ + + EI + K E+E P++ + E E+++ +L S
Sbjct: 424 KQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQE---TLIS 480
Query: 472 KKNLLESIPTHSDQEKEVN-----IKKPEDNENLDDKDDDTTRVDESLNIKVEAEEE 523
+K++ E +P +D +K++ KP + +KD++T + S + EA E+
Sbjct: 481 QKSIPEPLPA-ADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEK 536
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 88.2 bits (217), Expect = 4e-17
Identities = 149/652 (22%), Positives = 257/652 (39%), Gaps = 72/652 (11%)
Query: 366 YQDLGIPVLNSAAGYNVK-CAYKKYLYGFEEYCRSANIEFQMALPEKV-----VNKQCKE 419
YQDL LN +++ AY+K L G E CR +LPE + V+ K
Sbjct: 385 YQDL----LNVKMALDIEIAAYRKLLEG--EECRIGFGPIPFSLPEGLPKIPSVSTHIK- 437
Query: 420 CENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE-- 477
++ ++IKV E++E E ++ + E + E E++ ++E K G ++ E
Sbjct: 438 VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 478 -----SIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEW 532
S P E K P E + + +E+ + EKAKS E
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 533 IKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEM 592
K+ + +K K K K K K+E SP K +K P +
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKA-KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616
Query: 593 VSKLDLTDAKNSDTAHIKSIEITSILNGLQA-SESSAEDSEQEDERGAQDMDNNGKEESK 651
+K + + S A +KS E +A S A+ E+E+ + + + K E+K
Sbjct: 617 EAKSPVKEEAKS-PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675
Query: 652 IDHLTNNRNDLISKEEQNSSSLLEENKVHADLVIS--KPVSKSPERLRKDIEVLSEDTDY 709
+ +K + + S ++E + S K +KSPE+ + ++ ++ +
Sbjct: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735
Query: 710 EEDEVTKKRKDVKK-DTTDKSSKPQIKRGKRRYCNTEECL--------KTGSPGKKEEKA 760
+ V ++ K +K + +K+ +K + + EE K SP K+E K+
Sbjct: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKS 795
Query: 761 KNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRI 820
K ++ + + E ++ + K +P K+ EEK + EV K
Sbjct: 796 PEKAKSPLKEDAKAPEKEIPKKEEVK-SPVKE----EEKPQ------------EVKVKEP 838
Query: 821 KLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAE 880
++ + +++KD S + + PKK + + E A P + E E
Sbjct: 839 PKKAEEEKAPATPKTEEKKD---SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895
Query: 881 ESLQTVAEEESCSPSVELEKPPPVNV--DSKPIEEKTV---EVNDRKAEFPS------SG 929
E AE++ P+ E E P V V D+KP E+ V E +D KA+ PS
Sbjct: 896 E-----AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 930 SNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVS-EPLAPNQEEVRSIKSETD 980
+ +T + P TE ++ T+S EP P E+ S TD
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEK-SSSTD 1001
Score = 72.0 bits (175), Expect = 3e-12
Identities = 127/547 (23%), Positives = 209/547 (38%), Gaps = 53/547 (9%)
Query: 392 GFEEYCRSANIEFQMALPEKVVNKQCKE-CENVKEIKVKEENETEIK-EIKMEEERNIIP 449
G EE +S E + A PEK KE ++ E K E+ E + E+K E+
Sbjct: 496 GGEEETKSPPAE-EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 450 REE--KPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDT 507
+EE P E + KE K K P + + K PE ++ K++
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKS-PVKEEAK 613
Query: 508 TRVDESLNIKVEAEE-------EKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 560
+ + +K EA+ EKAKS E K+ + + +K + K +K K+ +
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE--EAKSPEKAKSPV- 670
Query: 561 KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNG 620
K E SP+ K P SPE +AK+ + A S +
Sbjct: 671 ----KAEAKSPEKAK-----SPVKAEAKSPEKAKSPVKEEAKSPEKA-------KSPVKE 714
Query: 621 LQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNN---RNDLISKEEQNSSSLLEEN 677
S A+ +E+ + + + KEE+K + L K + + EE
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEA 774
Query: 678 KVHADLVISKPVS------KSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSK 731
+ AD K S KSPE+ + L ED E E+ KK + K + K
Sbjct: 775 RSPADKFPEKAKSPVKEEVKSPEKAKSP---LKEDAKAPEKEIPKKEE--VKSPVKEEEK 829
Query: 732 PQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTK 791
PQ + K EE +P +E+K KE + + +E +E K +K
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 792 KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWP- 850
+E K++ + A ++++ ++ + + AK D + + P
Sbjct: 890 ----VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Query: 851 -KKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVN-VDS 908
KK D+ E A P E A+E +T+++E S + + EK + DS
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Query: 909 KPIEEKT 915
KP E+ T
Sbjct: 1006 KPPEKAT 1012
Score = 62.8 bits (151), Expect = 2e-09
Identities = 104/491 (21%), Positives = 187/491 (38%), Gaps = 72/491 (14%)
Query: 409 PEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPS 468
PEK + +E ++ E K E+ ++ +KE E + P+++E + +K
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKE-----EAKSPAEAKSPVKEEAKSPAEVKSP 635
Query: 469 LGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE-EKAKS 527
+K PT + + K PE K++ + +K EA+ EKAKS
Sbjct: 636 EKAKS------PTKEEAKSPEKAKSPE-------KEEAKSPEKAKSPVKAEAKSPEKAKS 682
Query: 528 GYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTN 587
+KA+ + +K +K K K K K+E SP+ K P +
Sbjct: 683 P----VKAE--AKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEKAK-----SPVKEEA 730
Query: 588 PSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGK 647
+PE +AK+ + A T + +A + E++ ++ + + K
Sbjct: 731 KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790
Query: 648 EESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP---ERLRKDIEVLS 704
EE K E+ S L E+ K + K KSP E ++++V
Sbjct: 791 EEVK-------------SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 705 EDTDYEEDEV-----TKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEK 759
EE++ T+++KD KK+ K P+ K +++ E+ ++ KKEE
Sbjct: 838 PPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 760 AKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKR 819
K+ E + + + E+ + T K + K K S+ AEK+
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP---------SKPAEKK 948
Query: 820 IKLLNNSDERLQNSRAKDRK----------DVWSSIQGQWPKKTLKELFSDSDTEAAASP 869
D + + ++ + K D S + PK E S +D + + P
Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD-QKDSKP 1007
Query: 870 PHPAPEEGVAE 880
P A E+ A+
Sbjct: 1008 PEKATEDKAAK 1018
Score = 57.0 bits (136), Expect = 1e-07
Identities = 74/373 (19%), Positives = 146/373 (39%), Gaps = 33/373 (8%)
Query: 409 PEKV---VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENI 465
PEK V + K E K E E + ++EE + + P+++E + E
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 466 KPSLGSKKNLLESI--PTHSDQEKEVNIKKPEDNENLDDKDDDT-TRVDESLNIKVEAEE 522
K + + E P + + K PE + LD K + T E +
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782
Query: 523 EKAKSGYDEWIKA-DKIVRPA-------DKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNC 574
EKAKS E +K+ +K P +K +PK ++++K+ + +E+ E +
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK---KEEVKSPVKEEEKPQEVKVKEPP 839
Query: 575 KLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQAS-ESSAEDSEQ 633
K K P + SK + K + ++ + ++ ++ E+ E++E
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED 899
Query: 634 EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSK-- 691
+ + + + K E K D + ++ KE ++ + SKP K
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP----------SKPAEKKE 949
Query: 692 -SPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKT 750
+PE+ KD + E+ + K K+ K + + SKP+ ++ ++ ++ K
Sbjct: 950 AAPEK--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007
Query: 751 GSPGKKEEKAKNK 763
+++ AK K
Sbjct: 1008 PEKATEDKAAKGK 1020
Score = 50.4 bits (119), Expect = 1e-05
Identities = 72/300 (24%), Positives = 107/300 (35%), Gaps = 41/300 (13%)
Query: 862 DTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPP-----PVNVDSK-PIEEKT 915
+ E A EEG EE + EE P+ E P PV ++K P E K+
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532
Query: 916 VEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEP---LAPNQEEV 972
E + K+ + +SP E +S V P +P +EE
Sbjct: 533 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592
Query: 973 RSIKSETDSTIEVDSVAGELQDLQSEGNS-------SPAGFDASVSSSSSNQPEPEHPEK 1025
+S +E S + S E +E S SPA + + S + E + PEK
Sbjct: 593 KS-PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651
Query: 1026 ACTGQK-RVKDAQGGGSSSKKQKRS-----------------HKATVVNNKKKGKGTNSS 1067
A + +K K + S K + +S K+ V K + S
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 1068 DSEELSAGESITKSQPVKSVSTGMKSHS-----TKSPARTQSPGKCGKNGDKDPDLKEPS 1122
EE + E KS + T K+ S KSP + +SP K K P+ K P+
Sbjct: 712 VKEEAKSPEK-AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Score = 37.0 bits (84), Expect = 0.12
Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 9/96 (9%)
Query: 218 KDGKFTSVPRKD-----VHEITSDTAPKPDAVLKQAFEQALEFHKSRTIP---ANWKTEL 269
KD K P+K+ V E KP +A ++ E K P A K E+
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916
Query: 270 KEDSSSSE-AEEEEEEEDDEKEKEDNSSEEEEEIEP 304
KED+ E E ++E DD K KE + E++E P
Sbjct: 917 KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Score = 36.6 bits (83), Expect = 0.15
Identities = 33/173 (19%), Positives = 66/173 (38%), Gaps = 8/173 (4%)
Query: 1058 KKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMK------SHSTKSPARTQSPGKCGKN 1111
+++GK + EE GE TKS P + ++ K KSPA +SP K +
Sbjct: 480 EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK--EE 537
Query: 1112 GDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASI 1171
++K P + + + ++ E + + K E K +++ +
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597
Query: 1172 DRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVE 1224
+ ++ K +E A + + + SP + + E + S + S E
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE 650
Score = 34.7 bits (78), Expect = 0.57
Identities = 26/89 (29%), Positives = 45/89 (50%), Gaps = 5/89 (5%)
Query: 225 VPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEE 284
+P+K+ + KP V + + E K+ PA KTE K+DS EA ++E
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA---PATPKTEEKKDSKKEEAPKKEAP 870
Query: 285 EDDEKEKEDNSSE--EEEEIEPFPEEREN 311
+ +EK++ + E +E ++E EE E+
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAED 899
Score = 32.7 bits (73), Expect = 2.2
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 2/61 (3%)
Query: 251 QALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERE 310
+ +E + T+ +TE E + E EEEE+E E+E ++ EEEE E EE +
Sbjct: 445 KVVEKSEKETVIVEEQTE--ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETK 502
Query: 311 N 311
+
Sbjct: 503 S 503
Score = 31.2 bits (69), Expect = 6.3
Identities = 38/165 (23%), Positives = 69/165 (41%), Gaps = 18/165 (10%)
Query: 151 EEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKD 210
EE++ ++ E++ D K+ +E K + K+ A+ P ++ KK+
Sbjct: 844 EEKAPATPKTEEKKDSKK-EEAPKKEAPKPKVEEKKEPAVEKPK-------ESKVEAKKE 895
Query: 211 NILVRSFKDGKFTSVPRKDVH---EITSDTAPKPDA-VLKQAFEQALEFHKSRTIPANWK 266
+D K P K+ E+ D PK V K+ + A S+
Sbjct: 896 EA-----EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 267 TELKEDSSSSEAEEEEEEEDDE-KEKEDNSSEEEEEIEPFPEERE 310
K+D+ +A++ EE+ E K KED+ + +E +P E+ E
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
>gi|62865637 AT rich interactive domain 3C (BRIGHT- like) [Homo
sapiens]
Length = 412
Score = 85.9 bits (211), Expect = 2e-16
Identities = 50/152 (32%), Positives = 79/152 (51%), Gaps = 35/152 (23%)
Query: 278 AEEEEEEEDDEKEKEDNSSEEE--EEIEP---------------FPEE------------ 308
AEEEE+ E+DE+++E+ +EEE EE P P E
Sbjct: 50 AEEEEDAEEDEEKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYE 109
Query: 309 ------RENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVW 362
R+ FL L+ FM+ RGTP+N+ P++ + L+L+ LFRLV GG + + VW
Sbjct: 110 LDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVW 169
Query: 363 KQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFE 394
++V + L +P ++A + ++ Y KYLY +E
Sbjct: 170 REVTRGLSLPTTITSAAFTLRTQYMKYLYPYE 201
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 82.4 bits (202), Expect = 2e-15
Identities = 157/771 (20%), Positives = 297/771 (38%), Gaps = 119/771 (15%)
Query: 409 PEKVVNKQCKECEN---VKEIKVKEENETEIKEIKM--EEERNIIPREE-KPIEDEIERK 462
P K +K KE + VKE KVK++ ++K K+ +EE+ P E+ KP++++ E++
Sbjct: 1054 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1113
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
+ G K+ ES + + I KP ++ + R E I + A
Sbjct: 1114 KRKTEEKGVDKDF-ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPA 1172
Query: 523 EKAKSGYDEWIKADKIVRPADKNVPKIK--------HRKKIKNKLDKEKDKDEKYSPKNC 574
+K K + K ++ P K ++K+K K+ ++ E S
Sbjct: 1173 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLV 1232
Query: 575 KLRRLSKPPFQTNPSPEMVSKLDLTDAK-----------NSDTAHIKSIEITSILNGLQA 623
S T SP S+ + TD K N +TA + + I +Q
Sbjct: 1233 DYTSTSS----TGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIM-----IQV 1282
Query: 624 SESSAE----DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI---SKEEQNSSSLLEE 676
+S + +SE+ED + Q + + GK S I +++ ++++ KE + S + +
Sbjct: 1283 PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKF 1342
Query: 677 NKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 736
K + +I V KS + + ++D DY E K+ + +K++T + + R
Sbjct: 1343 TKDVSHEIIQHEV-KSSKNSASSEKGKTKDRDYSVLE--KENPEKRKNSTQPEKESNLDR 1399
Query: 737 GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMT--PTKKYN 794
N + K+ S KE + +K +S+ +SS++D + K T T++Y+
Sbjct: 1400 -----LNEQGNFKSLSQSSKEARTSDK-----HDSTRASSNKDFTPNRDKKTDYDTREYS 1449
Query: 795 GLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERL-QNSRAKDRKDVWSSIQGQWPKKT 853
+ + + +E+ ++ N D Q ++ ++ +D+ PKK
Sbjct: 1450 SSKRRDEK----------NELTRRKDSPSRNKDSASGQKNKPREERDL--------PKKG 1491
Query: 854 LKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEE 913
+ + + + PH A ++ P+ E + +VD P ++
Sbjct: 1492 TGDSKKSNSSPSRDRKPH------------DHKATYDTKRPNEETK-----SVDKNPCKD 1534
Query: 914 KTVEVNDRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEV 972
+ V + + SSG+ + + PP T +T G +S+V P +
Sbjct: 1535 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT---GQIDKSTV------KPKPQLS 1585
Query: 973 RSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKR 1032
S + +D T E D A E +S+ S+ + + S + S + + EKA
Sbjct: 1586 HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDT 1645
Query: 1033 VKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMK 1092
Q G S ++ + ++ G T S S SA +K + K K
Sbjct: 1646 AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK 1705
Query: 1093 SHS---------------TKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKV 1128
H KS K KN DK+ + ++ ++ V
Sbjct: 1706 KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1756
Score = 72.0 bits (175), Expect = 3e-12
Identities = 155/810 (19%), Positives = 309/810 (38%), Gaps = 103/810 (12%)
Query: 418 KECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE 477
KE EN +++ K K EE + E +E + G ++N +
Sbjct: 885 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL------LETSRKSREPTGVEENKTD 938
Query: 478 SIPTHSDQEKEVNIK-KPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKAD 536
S+ ++ ++ +P D E++ K E K + ++ K K+ K +
Sbjct: 939 SLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKE 998
Query: 537 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL 596
IV+PA K + K+D E+++ SP+ S+PP + + E K
Sbjct: 999 NIVKPA----------KGPQEKVDGERER----SPR-------SEPPIK--KAKEETPKT 1035
Query: 597 DLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLT 656
D T + +S K + G S E ++ + ++ E+ K D+
Sbjct: 1036 DNTKSSSSSQKDEK-------ITGTPRKAHSKSAKEHQETKPVKE------EKVKKDYSK 1082
Query: 657 NNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTK 716
+ +++ ++ +E+ + E+N KP+ E+ ++ E D D+E +
Sbjct: 1083 DVKSEKLTTKEEKAKKPNEKN---------KPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1133
Query: 717 KRKDVK---KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSN 773
+ +V K + + +P ++ R + L + K + K+ EN SN
Sbjct: 1134 SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1193
Query: 774 SSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNS 833
+ ++ E+ + +K G + +RK T G S + V S R
Sbjct: 1194 TKEPSEKLESTSSKVKQEKVKG-KVRRKVTGTEG--SSSTLVDYTSTSSTGGSPVRKSEE 1250
Query: 834 RAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAA-ASPPHPAPEEGVAEESLQTVAEE-ES 891
+ ++ V KT++E +D+ A P+ ++ ++ E+ +S
Sbjct: 1251 KTDTKRTV---------IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKS 1301
Query: 892 CSPSVELEKPPPV--NVDSKP-----IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESP 944
P + KP V NV +KP EK E +++ +F S+ ++ S
Sbjct: 1302 TQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ--HEVKSSK 1359
Query: 945 SSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPA 1004
+S + +G + +V E P + + S + E +S ++ + G + L +
Sbjct: 1360 NSASSEKGKTKDRDYSVLEKENPEKRK-NSTQPEKESNLDRLNEQGNFKSLSQSSKEART 1418
Query: 1005 GFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS----HKATVVNNKKK 1060
+ +SSN+ + +K K D + SS ++ +++ K + NK
Sbjct: 1419 SDKHDSTRASSNKDFTPNRDK-----KTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS 1473
Query: 1061 GKGTNSSDSEELSAGESIT--KSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDP-- 1116
G + EE + T + S S K H K+ T+ P + K+ DK+P
Sbjct: 1474 ASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK 1533
Query: 1117 -----DLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASI 1171
L+ +N+ K + ++ E E+IT +I K + K +++
Sbjct: 1534 DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT------GQIDKSTVKPKPQLSHS 1587
Query: 1172 DRRRKRLKKKERESAATSSSSSSPSSSSIT 1201
R L ++ E+A + S S S+++
Sbjct: 1588 SRLSSDLTRETDEAAFEPDYNESDSESNVS 1617
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 82.4 bits (202), Expect = 2e-15
Identities = 157/771 (20%), Positives = 297/771 (38%), Gaps = 119/771 (15%)
Query: 409 PEKVVNKQCKECEN---VKEIKVKEENETEIKEIKM--EEERNIIPREE-KPIEDEIERK 462
P K +K KE + VKE KVK++ ++K K+ +EE+ P E+ KP++++ E++
Sbjct: 1088 PRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKR 1147
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
+ G K+ ES + + I KP ++ + R E I + A
Sbjct: 1148 KRKTEEKGVDKDF-ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPA 1206
Query: 523 EKAKSGYDEWIKADKIVRPADKNVPKIK--------HRKKIKNKLDKEKDKDEKYSPKNC 574
+K K + K ++ P K ++K+K K+ ++ E S
Sbjct: 1207 KKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLV 1266
Query: 575 KLRRLSKPPFQTNPSPEMVSKLDLTDAK-----------NSDTAHIKSIEITSILNGLQA 623
S T SP S+ + TD K N +TA + + I +Q
Sbjct: 1267 DYTSTSS----TGGSPVRKSE-EKTDTKRTVIKTMEEYNNDNTAPAEDVIIM-----IQV 1316
Query: 624 SESSAE----DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI---SKEEQNSSSLLEE 676
+S + +SE+ED + Q + + GK S I +++ ++++ KE + S + +
Sbjct: 1317 PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKF 1376
Query: 677 NKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 736
K + +I V KS + + ++D DY E K+ + +K++T + + R
Sbjct: 1377 TKDVSHEIIQHEV-KSSKNSASSEKGKTKDRDYSVLE--KENPEKRKNSTQPEKESNLDR 1433
Query: 737 GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMT--PTKKYN 794
N + K+ S KE + +K +S+ +SS++D + K T T++Y+
Sbjct: 1434 -----LNEQGNFKSLSQSSKEARTSDK-----HDSTRASSNKDFTPNRDKKTDYDTREYS 1483
Query: 795 GLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERL-QNSRAKDRKDVWSSIQGQWPKKT 853
+ + + +E+ ++ N D Q ++ ++ +D+ PKK
Sbjct: 1484 SSKRRDEK----------NELTRRKDSPSRNKDSASGQKNKPREERDL--------PKKG 1525
Query: 854 LKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEE 913
+ + + + PH A ++ P+ E + +VD P ++
Sbjct: 1526 TGDSKKSNSSPSRDRKPH------------DHKATYDTKRPNEETK-----SVDKNPCKD 1568
Query: 914 KTVEVNDRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEV 972
+ V + + SSG+ + + PP T +T G +S+V P +
Sbjct: 1569 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT---GQIDKSTV------KPKPQLS 1619
Query: 973 RSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKR 1032
S + +D T E D A E +S+ S+ + + S + S + + EKA
Sbjct: 1620 HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDT 1679
Query: 1033 VKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMK 1092
Q G S ++ + ++ G T S S SA +K + K K
Sbjct: 1680 AAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHK 1739
Query: 1093 SHS---------------TKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKV 1128
H KS K KN DK+ + ++ ++ V
Sbjct: 1740 KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVKSV 1790
Score = 72.0 bits (175), Expect = 3e-12
Identities = 155/810 (19%), Positives = 309/810 (38%), Gaps = 103/810 (12%)
Query: 418 KECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLE 477
KE EN +++ K K EE + E +E + G ++N +
Sbjct: 919 KESENAPGDGKGNKHKKHRKRRKGEESEGFLNPEL------LETSRKSREPTGVEENKTD 972
Query: 478 SIPTHSDQEKEVNIK-KPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKAD 536
S+ ++ ++ +P D E++ K E K + ++ K K+ K +
Sbjct: 973 SLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAVSKKE 1032
Query: 537 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKL 596
IV+PA K + K+D E+++ SP+ S+PP + + E K
Sbjct: 1033 NIVKPA----------KGPQEKVDGERER----SPR-------SEPPIK--KAKEETPKT 1069
Query: 597 DLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLT 656
D T + +S K + G S E ++ + ++ E+ K D+
Sbjct: 1070 DNTKSSSSSQKDEK-------ITGTPRKAHSKSAKEHQETKPVKE------EKVKKDYSK 1116
Query: 657 NNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTK 716
+ +++ ++ +E+ + E+N KP+ E+ ++ E D D+E +
Sbjct: 1117 DVKSEKLTTKEEKAKKPNEKN---------KPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1167
Query: 717 KRKDVK---KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSN 773
+ +V K + + +P ++ R + L + K + K+ EN SN
Sbjct: 1168 SKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1227
Query: 774 SSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNS 833
+ ++ E+ + +K G + +RK T G S + V S R
Sbjct: 1228 TKEPSEKLESTSSKVKQEKVKG-KVRRKVTGTEG--SSSTLVDYTSTSSTGGSPVRKSEE 1284
Query: 834 RAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAA-ASPPHPAPEEGVAEESLQTVAEE-ES 891
+ ++ V KT++E +D+ A P+ ++ ++ E+ +S
Sbjct: 1285 KTDTKRTV---------IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKS 1335
Query: 892 CSPSVELEKPPPV--NVDSKP-----IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESP 944
P + KP V NV +KP EK E +++ +F S+ ++ S
Sbjct: 1336 TQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQ--HEVKSSK 1393
Query: 945 SSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPA 1004
+S + +G + +V E P + + S + E +S ++ + G + L +
Sbjct: 1394 NSASSEKGKTKDRDYSVLEKENPEKRK-NSTQPEKESNLDRLNEQGNFKSLSQSSKEART 1452
Query: 1005 GFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS----HKATVVNNKKK 1060
+ +SSN+ + +K K D + SS ++ +++ K + NK
Sbjct: 1453 SDKHDSTRASSNKDFTPNRDK-----KTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS 1507
Query: 1061 GKGTNSSDSEELSAGESIT--KSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDP-- 1116
G + EE + T + S S K H K+ T+ P + K+ DK+P
Sbjct: 1508 ASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK 1567
Query: 1117 -----DLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASI 1171
L+ +N+ K + ++ E E+IT +I K + K +++
Sbjct: 1568 DREKHVLEARNNKESSGNKLLYILNPPETQVEKEQIT------GQIDKSTVKPKPQLSHS 1621
Query: 1172 DRRRKRLKKKERESAATSSSSSSPSSSSIT 1201
R L ++ E+A + S S S+++
Sbjct: 1622 SRLSSDLTRETDEAAFEPDYNESDSESNVS 1651
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 82.0 bits (201), Expect = 3e-15
Identities = 160/693 (23%), Positives = 270/693 (38%), Gaps = 127/693 (18%)
Query: 401 NIEFQMALPEKV--VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDE 458
N+E + EK + K K+ ++ KE V +E + + K+++E REEK I+D
Sbjct: 689 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDL 747
Query: 459 IERKENIKPSLGSKKNLL------ESIPTHSDQEKEVNIKK-----------PEDNENLD 501
E +ENI S+ L ESI H EKE++I+K PE +
Sbjct: 748 KEERENIPTDKDSEFTSLGMSAIEESIGLHL-VEKEIDIEKQEKHIKESKEKPEKRSQIK 806
Query: 502 DKDDDTTR---VDESLNIKVEAEEEKAKSGYDEWI----KADKIVR----------PADK 544
+KD + ++ IK E + EK K E + + DK+ K
Sbjct: 807 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 866
Query: 545 NVPKIKH-------RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLD 597
N IK R+K+ K DKEK + E++ ++ + + K Q++ S S+
Sbjct: 867 NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKG 926
Query: 598 LTDAKN-----------------SDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQ 640
K+ +++ HI+ + +SI++G +A S +E +
Sbjct: 927 KNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEP 985
Query: 641 DMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDI 700
+GKE+ K D + + +++ + L + K AD K S + K+
Sbjct: 986 LKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1045
Query: 701 EVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKA 760
++++D E KD++ + K K +IK+ ++ CL E K
Sbjct: 1046 RLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCL--------ELKI 1097
Query: 761 KNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRI 820
K+KE K K TPT E K K L S SEV +
Sbjct: 1098 KDKE-------------------KTKHTPT------ESKNKELTR----SKSSEVTDAYT 1128
Query: 821 KLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAE 880
K D S++ D K+V TL + SD SP + G++
Sbjct: 1129 KEKQPKDAVSNRSQSVDTKNV----------MTLGKSSFVSDNSLNRSPRSENEKPGLSS 1178
Query: 881 ESLQTV---AEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTP 937
S+ + + E+SC +V + PPV DS + +E ++ + F S S+ +P
Sbjct: 1179 RSVSMISVASSEDSCHTTVTTPR-PPVEYDS----DFMLESSESQMSFSQSPFLSIAKSP 1233
Query: 938 PT-TPESPSSVTVTEGSR--QQSSVTVSEPLAPNQEEVRSIKSETDSTIEV------DSV 988
E S + E + + ++ S + + E+V+ I SE TIEV +
Sbjct: 1234 ALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVI 1293
Query: 989 AGELQDLQSEGNSSPAGFDASVSSSSSNQPEPE 1021
+ Q+ S G +V +S P+PE
Sbjct: 1294 CEHTKQFQTISEESNQGSLLTVPGDTSPSPKPE 1326
Score = 54.7 bits (130), Expect = 5e-07
Identities = 155/830 (18%), Positives = 337/830 (40%), Gaps = 100/830 (12%)
Query: 432 NETEIKEIKMEEERNIIP--REEKPIEDEIERKENIKPSLGSKKNLLESIP--THSDQEK 487
+E + +K E + + E ++ ++ R +N + + + ++S S +K
Sbjct: 528 SEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQK 587
Query: 488 EVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVP 547
+ +++ E + N KD+D + E+ + ++ +++ K+ +K K+ K
Sbjct: 588 DFHLEFGEKS-NAKIKDEDHSPTFENSDCTLKKMDKEGKT-----LKKHKLKH---KERE 638
Query: 548 KIKHRKKIKNKLDKEKDKDE-KYSPKNCKL-RRLSKPPFQTNPSPEMVSKLDLTDAKNSD 605
K KH+K+I+ + +K K KD K ++ + R K F + E L L S
Sbjct: 639 KEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE---DLFLNMEHESL 695
Query: 606 TAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKE------ESKIDHLTNNR 659
T KS + ++ +S+ E ++ ++ D KE E KI L R
Sbjct: 696 TLEKKS----KLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 751
Query: 660 NDLISKEEQNSSSL----LEE----NKVHADLVISKP---VSKSPERLRKDIEVLSEDTD 708
++ + ++ +SL +EE + V ++ I K + +S E+ K ++ +D +
Sbjct: 752 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE 811
Query: 709 YEEDEVTKKRKDVK------KDTTDKSS-KPQIKRGKRRYC-NTEECLKTGSPGKK---- 756
E + +K K +K KD D S +IK + Y +TE+C K G K
Sbjct: 812 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 871
Query: 757 ---EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS 813
+++ K++E + + D+++ E + + +K+ + +E+K K S +S
Sbjct: 872 KKTDDREKSREKM------DRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN----SEYS 921
Query: 814 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA 873
+ + + K + ++ + SR K+ ++ +S Q KK+ S D A +
Sbjct: 922 KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKS-----SIVDGNKAQHEKPLS 976
Query: 874 PEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV 933
+E +E L+T +E ++++ + I+ ++ +A+ P S+
Sbjct: 977 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1036
Query: 934 LNTPPTTPESPSSV------TVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDS 987
+ T P+ V T E + + + ++E+++ + E + +
Sbjct: 1037 --SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK--QKEKERLRNRNC 1092
Query: 988 VAGELQDLQSEGNSSPAGFDASVSSSSSNQ-----PEPEHPEKACTGQKRVKDAQG---- 1038
+ +++D + ++ + ++ S S++ + + P+ A + + + D +
Sbjct: 1093 LELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTL 1152
Query: 1039 GGSSSKKQKRSHKATVVNNKKKGKGTNS------SDSEELSAGESITKSQPVKSVSTGMK 1092
G SS +++ N+K G + S + SE+ T PV+ S M
Sbjct: 1153 GKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFML 1212
Query: 1093 SHSTKSPARTQSP----GKCGKNGDKDPD-LKEPSNRLPKVYKWSFQMSDLENMTSAERI 1147
S + +QSP K +++ D L + R+ Y S L + + +
Sbjct: 1213 ESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVK 1272
Query: 1148 TILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERE-SAATSSSSSSPS 1196
I+ E I S+ S + ++ + + ++ + S T +SPS
Sbjct: 1273 LIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPS 1322
Score = 44.3 bits (103), Expect = 7e-04
Identities = 146/783 (18%), Positives = 308/783 (39%), Gaps = 138/783 (17%)
Query: 452 EKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVD 511
E+P++ + E ++ L + L + +++D E+ ++ +EN+D + + + +
Sbjct: 262 ERPVD--VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLIC 319
Query: 512 ESLNI-------KVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKE-- 562
ES I +E + K DE I +K++ D+++ + + RK+ + + +K
Sbjct: 320 ESKQILPSKTPLPSALDEYEFKDDDDEEI--NKMI--DDRHILRKEQRKENEPEAEKTHL 375
Query: 563 -KDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 621
+++ + PK+ K ++ KP S++ + ++SD +++ +I++ + +
Sbjct: 376 FAKQEKAFYPKSFKSKK-QKP-----------SRVLYSSTESSDEEALQNKKISTSCSVI 423
Query: 622 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 681
+ +S +++E + K++ K+ N+N +NK +
Sbjct: 424 PETSNSDMQTKKE-----YVVSGEHKQKGKVKRKLKNQN---------------KNKENQ 463
Query: 682 DLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKP----QIKRG 737
+L K + E R I L+ +T + E T++ + +K + K I G
Sbjct: 464 EL---KQEKEGKENTR--ITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTG 518
Query: 738 K--RRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE----EETKAKMTP-T 790
K + C E K +P K+E C+ S+ S + + + T+++ P +
Sbjct: 519 KSPKHSCGLSE--KQSTPLKQEH-----TKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 571
Query: 791 KKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWP 850
+ K KS F+ F E + +IK ++S +NS
Sbjct: 572 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHS-PTFENSDC--------------- 615
Query: 851 KKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKP 910
TLK++ + T H E+ ++ ++ E+ S + E V D +
Sbjct: 616 --TLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREF 672
Query: 911 IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVT---EGSRQQSSVTVSEPLAP 967
+E + ++ + F + S+ T E S + + S ++ V+
Sbjct: 673 WKENFFKSDETEDLFLNMEHESL------TLEKKSKLEKNIKDDKSTKEKHVSKERNF-- 724
Query: 968 NQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP----EHP 1023
+EE IK E++ + + +++DL+ E + P D+ +S + E
Sbjct: 725 -KEERDKIKKESEKSFREE----KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV 779
Query: 1024 EKACTGQKRVKDAQGGGSSSKKQKRSH---------KATVVNNKKKGKGTNSSDSEELSA 1074
EK +K+ K + S K +KRS + +KK K + S+ ++L
Sbjct: 780 EKEIDIEKQEKHIK--ESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDL 837
Query: 1075 GESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPD---LKEPSNRLPKVYKW 1131
E + K + + SH T+ KC K G+K + +K+ +R K
Sbjct: 838 SECVDKIKE----KDKLYSHHTE---------KCHKEGEKSKNTAAIKKTDDREKSREKM 884
Query: 1132 SFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSS 1191
+ D E + +EK +K+ S SE + ++ + + K +E + S
Sbjct: 885 D-RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRD 943
Query: 1192 SSS 1194
S
Sbjct: 944 KES 946
Score = 42.4 bits (98), Expect = 0.003
Identities = 112/544 (20%), Positives = 201/544 (36%), Gaps = 79/544 (14%)
Query: 256 HKSRTIPANWKTE--LKEDSSSSEAEEEEE----EEDDEKEKEDNSSEEEEEIEPFPEER 309
H+S T+ K E +K+D S+ E +E EE D+ +KE S EE+I+ EER
Sbjct: 692 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 751
Query: 310 ENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDL 369
EN P +K + +L G IE V +++
Sbjct: 752 ENI-------------PTDKDS--EFTSL-------------GMSAIEESIGLHLVEKEI 783
Query: 370 GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEI--K 427
I + + K+ ++ + F+ K +K K+ ++ E K
Sbjct: 784 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 843
Query: 428 VKEENET---EIKEIKMEEERNIIPREEKPIEDEIERKENI-----KPSLGSKKNLLESI 479
+KE+++ ++ E E++ K +D + +E + K +++L ES
Sbjct: 844 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 903
Query: 480 PTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEA-EEEKAKSGYDEWIKADKI 538
H ++K K+ +++E + D L+ K ++ ++E + I+ +K
Sbjct: 904 EKHLMEKKN---KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK 960
Query: 539 VRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDL 598
D N K +H K + KEK KDE P +T E K
Sbjct: 961 SSIVDGN--KAQHEKPLSL---KEKTKDE---------------PLKTPDGKEKDKKDKD 1000
Query: 599 TDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNN 658
D H I+I S+L +S A+ + + ++D K D + +
Sbjct: 1001 IDRYKERDKHKDKIQINSLLK----LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1056
Query: 659 RNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKR 718
++S ++ +++K K K ERLR + + D E+ + T
Sbjct: 1057 FERMLSLKDLEIEQWHKKHK-------EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1109
Query: 719 KDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDE 778
K+ T KSS+ K + ++ S K K S +NS N S
Sbjct: 1110 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1169
Query: 779 DEEE 782
+ E+
Sbjct: 1170 ENEK 1173
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 82.0 bits (201), Expect = 3e-15
Identities = 160/693 (23%), Positives = 270/693 (38%), Gaps = 127/693 (18%)
Query: 401 NIEFQMALPEKV--VNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDE 458
N+E + EK + K K+ ++ KE V +E + + K+++E REEK I+D
Sbjct: 712 NMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK-IKDL 770
Query: 459 IERKENIKPSLGSKKNLL------ESIPTHSDQEKEVNIKK-----------PEDNENLD 501
E +ENI S+ L ESI H EKE++I+K PE +
Sbjct: 771 KEERENIPTDKDSEFTSLGMSAIEESIGLHL-VEKEIDIEKQEKHIKESKEKPEKRSQIK 829
Query: 502 DKDDDTTR---VDESLNIKVEAEEEKAKSGYDEWI----KADKIVR----------PADK 544
+KD + ++ IK E + EK K E + + DK+ K
Sbjct: 830 EKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSK 889
Query: 545 NVPKIKH-------RKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLD 597
N IK R+K+ K DKEK + E++ ++ + + K Q++ S S+
Sbjct: 890 NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKG 949
Query: 598 LTDAKN-----------------SDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQ 640
K+ +++ HI+ + +SI++G +A S +E +
Sbjct: 950 KNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPL-SLKEKTKDEP 1008
Query: 641 DMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDI 700
+GKE+ K D + + +++ + L + K AD K S + K+
Sbjct: 1009 LKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1068
Query: 701 EVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKA 760
++++D E KD++ + K K +IK+ ++ CL E K
Sbjct: 1069 RLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCL--------ELKI 1120
Query: 761 KNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRI 820
K+KE K K TPT E K K L S SEV +
Sbjct: 1121 KDKE-------------------KTKHTPT------ESKNKELTR----SKSSEVTDAYT 1151
Query: 821 KLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAE 880
K D S++ D K+V TL + SD SP + G++
Sbjct: 1152 KEKQPKDAVSNRSQSVDTKNV----------MTLGKSSFVSDNSLNRSPRSENEKPGLSS 1201
Query: 881 ESLQTV---AEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTP 937
S+ + + E+SC +V + PPV DS + +E ++ + F S S+ +P
Sbjct: 1202 RSVSMISVASSEDSCHTTVTTPR-PPVEYDS----DFMLESSESQMSFSQSPFLSIAKSP 1256
Query: 938 PT-TPESPSSVTVTEGSR--QQSSVTVSEPLAPNQEEVRSIKSETDSTIEV------DSV 988
E S + E + + ++ S + + E+V+ I SE TIEV +
Sbjct: 1257 ALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVKLIISEGRPTIEVRRCSMPSVI 1316
Query: 989 AGELQDLQSEGNSSPAGFDASVSSSSSNQPEPE 1021
+ Q+ S G +V +S P+PE
Sbjct: 1317 CEHTKQFQTISEESNQGSLLTVPGDTSPSPKPE 1349
Score = 54.7 bits (130), Expect = 5e-07
Identities = 155/830 (18%), Positives = 337/830 (40%), Gaps = 100/830 (12%)
Query: 432 NETEIKEIKMEEERNIIP--REEKPIEDEIERKENIKPSLGSKKNLLESIP--THSDQEK 487
+E + +K E + + E ++ ++ R +N + + + ++S S +K
Sbjct: 551 SEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYDNTESEFLPESSSVKSCKHKEKSKHQK 610
Query: 488 EVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVP 547
+ +++ E + N KD+D + E+ + ++ +++ K+ +K K+ K
Sbjct: 611 DFHLEFGEKS-NAKIKDEDHSPTFENSDCTLKKMDKEGKT-----LKKHKLKH---KERE 661
Query: 548 KIKHRKKIKNKLDKEKDKDE-KYSPKNCKL-RRLSKPPFQTNPSPEMVSKLDLTDAKNSD 605
K KH+K+I+ + +K K KD K ++ + R K F + E L L S
Sbjct: 662 KEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETE---DLFLNMEHESL 718
Query: 606 TAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKE------ESKIDHLTNNR 659
T KS + ++ +S+ E ++ ++ D KE E KI L R
Sbjct: 719 TLEKKS----KLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
Query: 660 NDLISKEEQNSSSL----LEE----NKVHADLVISKP---VSKSPERLRKDIEVLSEDTD 708
++ + ++ +SL +EE + V ++ I K + +S E+ K ++ +D +
Sbjct: 775 ENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIE 834
Query: 709 YEEDEVTKKRKDVK------KDTTDKSS-KPQIKRGKRRYC-NTEECLKTGSPGKK---- 756
E + +K K +K KD D S +IK + Y +TE+C K G K
Sbjct: 835 KMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAI 894
Query: 757 ---EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS 813
+++ K++E + + D+++ E + + +K+ + +E+K K S +S
Sbjct: 895 KKTDDREKSREKM------DRKHDKEKPEKERHLAESKEKHLMEKKNKQSDN----SEYS 944
Query: 814 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPA 873
+ + + K + ++ + SR K+ ++ +S Q KK+ S D A +
Sbjct: 945 KSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKS-----SIVDGNKAQHEKPLS 999
Query: 874 PEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSV 933
+E +E L+T +E ++++ + I+ ++ +A+ P S+
Sbjct: 1000 LKEKTKDEPLKTPDGKEKDKKDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPA 1059
Query: 934 LNTPPTTPESPSSV------TVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDS 987
+ T P+ V T E + + + ++E+++ + E + +
Sbjct: 1060 --SKDTRPKEKRLVNDDLMQTSFERMLSLKDLEIEQWHKKHKEKIK--QKEKERLRNRNC 1115
Query: 988 VAGELQDLQSEGNSSPAGFDASVSSSSSNQ-----PEPEHPEKACTGQKRVKDAQG---- 1038
+ +++D + ++ + ++ S S++ + + P+ A + + + D +
Sbjct: 1116 LELKIKDKEKTKHTPTESKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTL 1175
Query: 1039 GGSSSKKQKRSHKATVVNNKKKGKGTNS------SDSEELSAGESITKSQPVKSVSTGMK 1092
G SS +++ N+K G + S + SE+ T PV+ S M
Sbjct: 1176 GKSSFVSDNSLNRSPRSENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPPVEYDSDFML 1235
Query: 1093 SHSTKSPARTQSP----GKCGKNGDKDPD-LKEPSNRLPKVYKWSFQMSDLENMTSAERI 1147
S + +QSP K +++ D L + R+ Y S L + + +
Sbjct: 1236 ESSESQMSFSQSPFLSIAKSPALHERELDSLADLPERIKPPYANRLSTSHLRSSSVEDVK 1295
Query: 1148 TILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERE-SAATSSSSSSPS 1196
I+ E I S+ S + ++ + + ++ + S T +SPS
Sbjct: 1296 LIISEGRPTIEVRRCSMPSVICEHTKQFQTISEESNQGSLLTVPGDTSPS 1345
Score = 44.3 bits (103), Expect = 7e-04
Identities = 146/783 (18%), Positives = 308/783 (39%), Gaps = 138/783 (17%)
Query: 452 EKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVD 511
E+P++ + E ++ L + L + +++D E+ ++ +EN+D + + + +
Sbjct: 285 ERPVD--VAETEELELLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLIC 342
Query: 512 ESLNI-------KVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKE-- 562
ES I +E + K DE I +K++ D+++ + + RK+ + + +K
Sbjct: 343 ESKQILPSKTPLPSALDEYEFKDDDDEEI--NKMI--DDRHILRKEQRKENEPEAEKTHL 398
Query: 563 -KDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGL 621
+++ + PK+ K ++ KP S++ + ++SD +++ +I++ + +
Sbjct: 399 FAKQEKAFYPKSFKSKK-QKP-----------SRVLYSSTESSDEEALQNKKISTSCSVI 446
Query: 622 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA 681
+ +S +++E + K++ K+ N+N +NK +
Sbjct: 447 PETSNSDMQTKKE-----YVVSGEHKQKGKVKRKLKNQN---------------KNKENQ 486
Query: 682 DLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKP----QIKRG 737
+L K + E R I L+ +T + E T++ + +K + K I G
Sbjct: 487 EL---KQEKEGKENTR--ITNLTVNTGLDCSEKTREEGNFRKSFSPKDDTSLHLFHISTG 541
Query: 738 K--RRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE----EETKAKMTP-T 790
K + C E K +P K+E C+ S+ S + + + T+++ P +
Sbjct: 542 KSPKHSCGLSE--KQSTPLKQEH-----TKTCLSPGSSEMSLQPDLVRYDNTESEFLPES 594
Query: 791 KKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWP 850
+ K KS F+ F E + +IK ++S +NS
Sbjct: 595 SSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHS-PTFENSDC--------------- 638
Query: 851 KKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKP 910
TLK++ + T H E+ ++ ++ E+ S + E V D +
Sbjct: 639 --TLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAK-ELQRSVEFDREF 695
Query: 911 IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVT---EGSRQQSSVTVSEPLAP 967
+E + ++ + F + S+ T E S + + S ++ V+
Sbjct: 696 WKENFFKSDETEDLFLNMEHESL------TLEKKSKLEKNIKDDKSTKEKHVSKERNF-- 747
Query: 968 NQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEP----EHP 1023
+EE IK E++ + + +++DL+ E + P D+ +S + E
Sbjct: 748 -KEERDKIKKESEKSFREE----KIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLV 802
Query: 1024 EKACTGQKRVKDAQGGGSSSKKQKRSH---------KATVVNNKKKGKGTNSSDSEELSA 1074
EK +K+ K + S K +KRS + +KK K + S+ ++L
Sbjct: 803 EKEIDIEKQEKHIK--ESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDL 860
Query: 1075 GESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPD---LKEPSNRLPKVYKW 1131
E + K + + SH T+ KC K G+K + +K+ +R K
Sbjct: 861 SECVDKIKE----KDKLYSHHTE---------KCHKEGEKSKNTAAIKKTDDREKSREKM 907
Query: 1132 SFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSS 1191
+ D E + +EK +K+ S SE + ++ + + K +E + S
Sbjct: 908 D-RKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRD 966
Query: 1192 SSS 1194
S
Sbjct: 967 KES 969
Score = 42.4 bits (98), Expect = 0.003
Identities = 112/544 (20%), Positives = 201/544 (36%), Gaps = 79/544 (14%)
Query: 256 HKSRTIPANWKTE--LKEDSSSSEAEEEEE----EEDDEKEKEDNSSEEEEEIEPFPEER 309
H+S T+ K E +K+D S+ E +E EE D+ +KE S EE+I+ EER
Sbjct: 715 HESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEER 774
Query: 310 ENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDL 369
EN P +K + +L G IE V +++
Sbjct: 775 ENI-------------PTDKDS--EFTSL-------------GMSAIEESIGLHLVEKEI 806
Query: 370 GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEI--K 427
I + + K+ ++ + F+ K +K K+ ++ E K
Sbjct: 807 DIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDK 866
Query: 428 VKEENET---EIKEIKMEEERNIIPREEKPIEDEIERKENI-----KPSLGSKKNLLESI 479
+KE+++ ++ E E++ K +D + +E + K +++L ES
Sbjct: 867 IKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESK 926
Query: 480 PTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEA-EEEKAKSGYDEWIKADKI 538
H ++K K+ +++E + D L+ K ++ ++E + I+ +K
Sbjct: 927 EKHLMEKKN---KQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKK 983
Query: 539 VRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDL 598
D N K +H K + KEK KDE P +T E K
Sbjct: 984 SSIVDGN--KAQHEKPLSL---KEKTKDE---------------PLKTPDGKEKDKKDKD 1023
Query: 599 TDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNN 658
D H I+I S+L +S A+ + + ++D K D + +
Sbjct: 1024 IDRYKERDKHKDKIQINSLLK----LKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1079
Query: 659 RNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKR 718
++S ++ +++K K K ERLR + + D E+ + T
Sbjct: 1080 FERMLSLKDLEIEQWHKKHK-------EKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1132
Query: 719 KDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDE 778
K+ T KSS+ K + ++ S K K S +NS N S
Sbjct: 1133 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1192
Query: 779 DEEE 782
+ E+
Sbjct: 1193 ENEK 1196
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 79.7 bits (195), Expect = 2e-14
Identities = 125/538 (23%), Positives = 205/538 (38%), Gaps = 86/538 (15%)
Query: 622 QASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNR-----NDLISKEEQNSSSLLEE 676
+AS S +EDS +E+E +K L + ++ S EE + E+
Sbjct: 81 KASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 677 NKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 736
K KP +K+ + K + S D+D + + K+ K T + K Q K
Sbjct: 141 QKKQPVQKGVKPQAKAAKAPPKKAK--SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKA 198
Query: 737 GKRRYCNTEECLKTGSPGKKEEKAKN-KESLCMENSSNSSSDEDEEETKAKMTPTK---- 791
+ P + K N K + +SS+SSS +D EE KA TP K
Sbjct: 199 PPK-------------PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK 245
Query: 792 KYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSI---QGQ 848
K + K+ T S SE + ++ +E Q K++ +SS+
Sbjct: 246 KQVVAKAPVKAATTPTRKSSSSEDS-------SSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
Query: 849 WPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDS 908
PKK+L PP A E+ ES + + +ES S S E +KPP V S
Sbjct: 299 PPKKSL-----------GTQPPKKAVEKQQPVESSED-SSDESDSSSEEEKKPPTKAVVS 346
Query: 909 KPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPL--- 965
K + + AE S S+S + P P+ T + S + +VT P
Sbjct: 347 KATTKPPPA--KKAAESSSDSSDSDSSEDDEAPSKPAGTT--KNSSNKPAVTTKSPAVKP 402
Query: 966 --APNQ-----EEVRSIKSETDSTIEVDSVAGELQD----------------LQSEGNSS 1002
AP Q +++ + K+++ S+ E S + E + L +
Sbjct: 403 AAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQA 462
Query: 1003 PAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGK 1062
P G S S S S+ E E + + + K+ GG++ K + K ++
Sbjct: 463 PQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS 522
Query: 1063 GTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKE 1120
+S + EE G+ + Q K+ T A T GK KN +++ + K+
Sbjct: 523 DDSSEEEEEKLKGKGSPRPQAPKANGTS---------ALTAQNGKAAKNSEEEEEEKK 571
Score = 56.6 bits (135), Expect = 1e-07
Identities = 79/359 (22%), Positives = 130/359 (36%), Gaps = 76/359 (21%)
Query: 519 EAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRR 578
++EEEKA + + + ++V A RK ++ +++E+ P K
Sbjct: 229 DSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGP 288
Query: 579 LSKPPFQTNPSPE-----------------MVSKLDLTDAKNSDTAHIKSIEITSILNGL 621
S P + P P+ + S D +D +S + K ++++
Sbjct: 289 YSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKA 348
Query: 622 ------------QASESSAEDSEQEDERGAQDMDNNGKEESKI----------------- 652
+S+SS DS ++DE ++ +K
Sbjct: 349 TTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQ 408
Query: 653 -----DHLTNNRNDLISKEEQNSSSLLEENK---------VHADLVISKPVSKSPERLRK 698
L + D S EE++SSS E+ K A +S P ++P+ R
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRD 468
Query: 699 DIEVLSEDTDYEEDEVTKK----RKDVKKDTTDKSSKP-QIKRGKRRYCNT--------- 744
+ EE+E T K +K K SKP K+GK N+
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528
Query: 745 -EECLK-TGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRK 801
EE LK GSP + KA +L +N + + E+EEE K K +G +KRK
Sbjct: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRK 587
Score = 43.9 bits (102), Expect = 0.001
Identities = 108/606 (17%), Positives = 204/606 (33%), Gaps = 79/606 (13%)
Query: 262 PANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFME 321
P + E SSS E+ ++++EED +K+ + + + P ++
Sbjct: 116 PGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSS 175
Query: 322 DRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYN 381
+ P N++P + + K + P + N
Sbjct: 176 EDEPPKNQKPKI------------------------TPVTVKAQTKAPPKPARAAPKIAN 211
Query: 382 VKCAYKKYLYGFEEYCRSANIEFQMALPEKVV-NKQCKECENVKEIKVKEENETEIKEIK 440
K A + E A P+K V KQ VK + ++
Sbjct: 212 GKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSS 271
Query: 441 MEEERNIIPREEKPIEDEIERKENIKP-SLGSKKNLLESIPTHSDQEKEVNIKKPEDNEN 499
+EE ++KP++++ ++ P S K L + P EK+ ++ ED+ +
Sbjct: 272 SDEEEE----QKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSD 327
Query: 500 LDDKDDDTTRVDESLNI--KVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKN 557
D + + + + K + AK + + D P K KN
Sbjct: 328 ESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPS-KPAGTTKN 386
Query: 558 KLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI 617
+K + + K + Q + + S ++ +S+ K + T+
Sbjct: 387 SSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTK 446
Query: 618 LNGLQASESS--AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLE 675
+ S A+ + Q + D D++ EE +EE+ S S ++
Sbjct: 447 PKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE---------------EEEKTSKSAVK 491
Query: 676 EN--KVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQ 733
+ KV SKP S + S+D+ EE+E K + S +PQ
Sbjct: 492 KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG---------SPRPQ 542
Query: 734 IKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKY 793
+ T + K ++EE+ K K ++ + S + + E K TP K
Sbjct: 543 APKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKK 602
Query: 794 ------NGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRK-DVWSSIQ 846
N +++K + S F V E+ I++ +SR D D
Sbjct: 603 IKLQTPNTFPKRKKGEKRAS--SPFRRVREEEIEV---------DSRVADNSFDAKRGAA 651
Query: 847 GQWPKK 852
G W ++
Sbjct: 652 GDWGER 657
Score = 39.7 bits (91), Expect = 0.018
Identities = 44/171 (25%), Positives = 74/171 (43%), Gaps = 16/171 (9%)
Query: 1042 SSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVST-----GMKSHST 1096
S+K +R +A KK K +SSDSE+ S E + P K + G+
Sbjct: 60 SAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKA 119
Query: 1097 KSPARTQSPGKCGKNGDKDPDLKE--------PSNRLPKVYKWSFQMSDLENMTSAERIT 1148
+ A S + + D + D K+ P + K + SD ++ +S+E
Sbjct: 120 AAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEP 179
Query: 1149 ILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSS 1199
K Q+ + +++K++ + + + K AA+SSSSSS SSSS
Sbjct: 180 ---PKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
Score = 37.4 bits (85), Expect = 0.088
Identities = 62/320 (19%), Positives = 111/320 (34%), Gaps = 61/320 (19%)
Query: 813 SEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKE---LFSDSDTEAAASP 869
SEVA K K + + S D W + P++ L+ + + +A++S
Sbjct: 28 SEVANKFAKATGATQQDANASSLLDIYSFWLK-SAKVPERKLQANGPVAKKAKKKASSSD 86
Query: 870 PHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSG 929
+ EE EE +Q +++ P+ + PP + A S
Sbjct: 87 SEDSSEE---EEEVQGPPAKKAAVPAKRVGLPP-----------------GKAAAKASES 126
Query: 930 SNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVA 989
S+S ++ E V +G + Q+ + P ++ +S S++DS+ E +
Sbjct: 127 SSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPP-----KKAKSSDSDSDSSSEDEPPK 181
Query: 990 GELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS 1049
N P +V + + P+P K + SSS
Sbjct: 182 ----------NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSS------ 225
Query: 1050 HKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCG 1109
+S DSEE A + K+ P K V + +P R S +
Sbjct: 226 ---------------SSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE-D 269
Query: 1110 KNGDKDPDLKEPSNRLPKVY 1129
+ D++ + K+P P Y
Sbjct: 270 SSSDEEEEQKKPMKNKPGPY 289
Score = 33.1 bits (74), Expect = 1.7
Identities = 37/162 (22%), Positives = 62/162 (38%), Gaps = 32/162 (19%)
Query: 134 PVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFP 193
PV G + R+++ EE SSSS E+E +K + K +SL K+A
Sbjct: 409 PVGGGQKLLTRKADSSSSEEESSSS--EEEKTKKMVATTKPKATAKAALSLPAKQA---- 462
Query: 194 ALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQAL 253
P S + + D+ ++ S +K ++ AP A K+
Sbjct: 463 -----PQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG----- 512
Query: 254 EFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNS 295
K +SS+S + ++ EE++EK K S
Sbjct: 513 ----------------KAESSNSSSSDDSSEEEEEKLKGKGS 538
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 79.0 bits (193), Expect = 3e-14
Identities = 159/812 (19%), Positives = 306/812 (37%), Gaps = 119/812 (14%)
Query: 407 ALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIK 466
A EK V K+ K VK KEE E KE+ +E++ I +EEKP ++E+++
Sbjct: 632 AAKEKTVKKETK----VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKK----- 682
Query: 467 PSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK 526
E + IKK E E + +T + +K E ++E K
Sbjct: 683 -------------------EVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKK 723
Query: 527 SGYDEWIKADKIVRPADKNVPKIKHRKK---IKNKLDKEKDKDEKYS-----PKNCKLRR 578
+ + K+ + A K+ + KK +K K+ K+++ +K S PK +
Sbjct: 724 EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIK 783
Query: 579 LSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERG 638
+ K + + T A A I +I L ++ SS ED
Sbjct: 784 VIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDL------- 836
Query: 639 AQDMDNNGKEESKIDHLTNNRNDLISKEEQ-NSSSLLEENKVHADLVISKPVSKSPERLR 697
+D + EE + + +LI EE+ + +E + + ++K ++SP
Sbjct: 837 TKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESP---- 892
Query: 698 KDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKK- 756
D + + + + E ++ ++ + V+K D I++ + EE +TG +K
Sbjct: 893 -DEGITTTEGEGECEQTPEELEPVEKQGVD-----DIEKFEDEGAGFEESSETGDYEEKA 946
Query: 757 -----EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSG 811
EE ++ E ++S S EDEE KA+ + EKR+S+ SG
Sbjct: 947 ETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAY-----IREKRESVA-----SG 996
Query: 812 FSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQW-PKKTLKELFSDSDTEAAASPP 870
E + + + A + + + ++ P+K E + + + AA
Sbjct: 997 DDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAA--- 1053
Query: 871 HPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGS 930
E G AEE + +P+ +L P + I ++T+ S S
Sbjct: 1054 ----EAGGAEEQYGFLT-----TPTKQLGAQSPGREPASSIHDETLP--------GGSES 1096
Query: 931 NSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEV-RSIKSETDSTIEVDSVA 989
+ + + P T T G Q + SEP ++ R + S+ + E +S +
Sbjct: 1097 EATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPS 1156
Query: 990 GELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS 1049
E ++ +++S+ S ++P P + + G ++ S
Sbjct: 1157 QEFVNITK--------YESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTIS 1208
Query: 1050 HKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCG 1109
+++ +K + E+ A ++ + +VS+ S S KSP+ + SP
Sbjct: 1209 PPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPS-KSPSLSPSP---- 1263
Query: 1110 KNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVA 1169
P E + + +S ++++ AE + E QE+ + + + +
Sbjct: 1264 ------PSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPED-- 1315
Query: 1170 SIDRRRKRLKKKERESAATSSSSSSPSSSSIT 1201
K L+ + T S+ +P S T
Sbjct: 1316 ------KTLEVVSPSQSVTGSAGHTPYYQSPT 1341
Score = 73.9 bits (180), Expect = 9e-13
Identities = 158/743 (21%), Positives = 277/743 (37%), Gaps = 162/743 (21%)
Query: 408 LPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKP 467
LP K V K+ KE + +V + N E K K+E + ++ +++KPI+ E KP
Sbjct: 552 LPSKSVRKESKE----ETPEVTKVNHVE-KPPKVESKEKVMVKKDKPIKTET------KP 600
Query: 468 SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKS 527
S+ K+ +P+ ++E + K E E +A + K K+
Sbjct: 601 SVTEKE-----VPS----KEEPSPVKAEVAEK-------------------QATDVKPKA 632
Query: 528 GYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD--------------------KEKDKDE 567
++ +K + V+P DK K K +K++ K D KE K+E
Sbjct: 633 AKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEE 692
Query: 568 KYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESS 627
K PK K + PP + + K ++ + IK + + + SE+
Sbjct: 693 KKEPK--KEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAK 750
Query: 628 AEDS-----EQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHA- 681
+ +++E +D GK + K + +I KE + + ++ A
Sbjct: 751 KPAALKPKVPKKEESVKKDSVAAGKPKEK------GKIKVIKKEGKAAEAVAAAVGTGAT 804
Query: 682 -----------------DLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKD 724
+L + + SPE L KD E L EE +VT
Sbjct: 805 TAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKA----EEVDVT--------- 851
Query: 725 TTDKSSKPQIKRGKRRYCNTEECLKTGSP------GKKEEKAKNKESLCMENSSNSSSDE 778
K KPQ++ EE LK P K+ E K E + + +
Sbjct: 852 ---KDIKPQLE-----LIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG 903
Query: 779 DEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDR 838
+ E+T ++ P +K G+++ K G +GF E +E E +
Sbjct: 904 ECEQTPEELEPVEK-QGVDDIEK-FEDEG--AGFEESSETGDYEEKAETEEAEEPEEDGE 959
Query: 839 KDVWSSIQGQWPKKTLKELFSDSDT------EAAASPPHPAPEE-------GVAEESLQT 885
+ V S P + + +++D E+ AS A E+ G AE+S +
Sbjct: 960 EHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE 1019
Query: 886 VAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTP---- 941
EE+ + E E P + E+ + V D+ AE + T PT
Sbjct: 1020 ADEEDKAEDAREEEYEP----EKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQ 1075
Query: 942 ----ESPSSV---TVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQD 994
E SS+ T+ GS +++ + E EE + T STIE+ S + +
Sbjct: 1076 SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE 1135
Query: 995 LQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1054
+ S+P V S +N E E P + + + + S++ + T
Sbjct: 1136 M-----STP----RDVMSDETNNEETESPSQEFVNITKYESS----LYSQEYSKPADVTP 1182
Query: 1055 VNNKKKGKGTNSSDSEELSAGES 1077
+N +G T+++D ++ +A S
Sbjct: 1183 LNGFSEGSKTDATDGKDYNASAS 1205
Score = 57.8 bits (138), Expect = 6e-08
Identities = 169/901 (18%), Positives = 320/901 (35%), Gaps = 120/901 (13%)
Query: 197 VCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFH 256
V P + E VKK+ + K + P+K+V + T K + E
Sbjct: 628 VKPKAAKEKTVKKETKVKPEDKKEE-KEKPKKEVAKKEDKTPIKKE-----------EKP 675
Query: 257 KSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQL 316
K + K E+K++ +E ++E ++ K++ EE++E++ +E + +++L
Sbjct: 676 KKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKL 735
Query: 317 YKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHK--LGGFDNIESGAVWKQVYQDLGIPVL 374
K + TP+++ + K V K + E G + + +
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAV 795
Query: 375 NSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMAL---PEKVVNKQCKECENVK--EIKVK 429
+A G A G + +E + +L PE + K+ E +K E+ V
Sbjct: 796 AAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLT----KDFEELKAEEVDVT 851
Query: 430 EENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEV 489
++ + +++ I+ EE+ +E +P+E + +KE + + G ++ E I T ++ E E
Sbjct: 852 KDIKPQLELIEDEEKL----KETEPVEAYVIQKER-EVTKGPAESPDEGITT-TEGEGEC 905
Query: 490 NIKKPEDNENLDDK--DDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVP 547
+ PE+ E ++ + DD DE EE Y+E + ++ P +
Sbjct: 906 E-QTPEELEPVEKQGVDDIEKFEDEGAGF----EESSETGDYEEKAETEEAEEPEEDGE- 959
Query: 548 KIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTA 607
+H +K +D++ + + +R E V+ D ++ D A
Sbjct: 960 --EHVCVSASKHSPTEDEESAKAEADAYIRE----------KRESVASGDDRAEEDMDEA 1007
Query: 608 HIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEE 667
K Q+ E + E+ + ED R + + E + + + + EE
Sbjct: 1008 IEKG-------EAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
Query: 668 QNSSSLLEENKVHADLVISKPVSKSPERLR---KDIEVLSEDTDYEEDE---------VT 715
Q ++ A +P S + + E + D + ED+ T
Sbjct: 1061 QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYT 1120
Query: 716 KKRKDVKKDTT--DKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSN 773
+ ++ + T D+ S P+ N EE T SP ++ ES +
Sbjct: 1121 QSTIEISSEPTPMDEMSTPRDVMSDET--NNEE---TESPSQEFVNITKYESSLYSQEYS 1175
Query: 774 SSSDED-----EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDE 828
+D E +K T K YN S T S E R L +
Sbjct: 1176 KPADVTPLNGFSEGSKTDATDGKDYNA------SASTISPPSSMEEDKFSRSALRDAYCS 1229
Query: 829 RLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAE 888
++ S D KD S++ + ++ + SPP P + + E S+
Sbjct: 1230 EVKASTTLDIKDSISAVSSE-------KVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLT 1282
Query: 889 EESCSPSVELEKPP-PVNVDSKPIEEKTVEVNDRKAEFPSSGSN---------------- 931
S E E P V + +EE D+ E S +
Sbjct: 1283 PNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTD 1342
Query: 932 --------SVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTI 983
V+ PP P S + + + S + EP+ ++ + + S S
Sbjct: 1343 EKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPP 1402
Query: 984 EVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEH--PEKACTGQKRVKDAQGGGS 1041
+ S + L ++ +S G ++ S Q P+ P T +D Q G S
Sbjct: 1403 LIGSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKS 1462
Query: 1042 S 1042
+
Sbjct: 1463 T 1463
Score = 48.9 bits (115), Expect = 3e-05
Identities = 100/537 (18%), Positives = 196/537 (36%), Gaps = 80/537 (14%)
Query: 705 EDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKE 764
+++ E EVTK K + K +K+ K T+ + KEE + K
Sbjct: 559 KESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKA 618
Query: 765 SLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLN 824
+ + +++ +E+T K T K + EEK K + EVA+K K
Sbjct: 619 EVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKK---------EVAKKEDKTPI 669
Query: 825 NSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQ 884
+E+ + K K+V I+ + K+ KE+ + +PP +E EE +
Sbjct: 670 KKEEKPKKEEVK--KEVKKEIKKEEKKEPKKEVKKE-------TPPKEVKKEVKKEEKKE 720
Query: 885 TVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESP 944
EE+ P E++K P + +K+ P S + P P+
Sbjct: 721 VKKEEK--EPKKEIKKLPK---------------DAKKSSTPLSEAKKPAALKPKVPKKE 763
Query: 945 SSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPA 1004
SV ++ SV +P + +++ IK E + V + G G ++ A
Sbjct: 764 ESV-------KKDSVAAGKP--KEKGKIKVIKKEGKAAEAVAAAVG-------TGATTAA 807
Query: 1005 GFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGT 1064
A+ ++ P K ++ + + + ++ ++ + V + K
Sbjct: 808 VMAAAGIAAIG-------PAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK----- 855
Query: 1065 NSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPAR--------TQSPGKCGKNGDK-D 1115
E + E + +++PV++ + TK PA T+ G+C + ++ +
Sbjct: 856 --PQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELE 913
Query: 1116 PDLKEPSNRLPKV------YKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVA 1169
P K+ + + K ++ S + D E E +E +E S S
Sbjct: 914 PVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTE 973
Query: 1170 SIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR 1226
+ + RE + +S + + A+ AE S A + + + R
Sbjct: 974 DEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 1030
Score = 44.7 bits (104), Expect = 6e-04
Identities = 64/313 (20%), Positives = 128/313 (40%), Gaps = 41/313 (13%)
Query: 908 SKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGS--RQQSSVTVSEPL 965
+KP+ K+V + K E P + + PP ES V V + + ++ +V+E
Sbjct: 549 AKPLPSKSVR-KESKEETPEVTKVNHVEKPPKV-ESKEKVMVKKDKPIKTETKPSVTEKE 606
Query: 966 APNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEK 1025
P++EE +K+ E+ + Q+ A + +V + +PE + EK
Sbjct: 607 VPSKEEPSPVKA-------------EVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEK 653
Query: 1026 ACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVK 1085
++ K + + KK+++ K V KK E+ + + K P K
Sbjct: 654 EKPKKEVAK--KEDKTPIKKEEKPKKEEVKKEVKK----EIKKEEKKEPKKEVKKETPPK 707
Query: 1086 SVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAE 1145
V +K K K +K+P K+ +LPK K S ++ A+
Sbjct: 708 EVKKEVKKEEKKEV----------KKEEKEP--KKEIKKLPKDAKKS-----STPLSEAK 750
Query: 1146 RITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVM 1205
+ L+ K+ + ++ + S A + + ++K ++E A + +++ + + TAAVM
Sbjct: 751 KPAALKPKVPK-KEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVM 809
Query: 1206 LTLAEPSMSSASQ 1218
++ A +
Sbjct: 810 AAAGIAAIGPAKE 822
>gi|47078224 AT rich interactive domain 5A [Homo sapiens]
Length = 594
Score = 77.0 bits (188), Expect = 1e-13
Identities = 53/157 (33%), Positives = 79/157 (50%), Gaps = 8/157 (5%)
Query: 289 KEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVH 348
++ + E EEE E EE + FL LYKFM++R TPI + P LG++ +NL+K+++ V
Sbjct: 40 EDSPEAGGEREEEQER--EEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVE 97
Query: 349 KLGGFDNIESGAVWKQVYQDL-GIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMA 407
KLG ++ + +WK VY +L G P SAA C + Y Y R E
Sbjct: 98 KLGAYELVTGRRLWKNVYDELGGSPGSTSAA----TCTRRHYERLVLPYVRHLKGEDDKP 153
Query: 408 LPEKVVNKQCKEC-ENVKEIKVKEENETEIKEIKMEE 443
LP KQ K EN + E + +E +M++
Sbjct: 154 LPTSKPRKQYKMAKENRGDDGATERPKKAKEERRMDQ 190
>gi|5453638 AT rich interactive domain 3B [Homo sapiens]
Length = 560
Score = 76.3 bits (186), Expect = 2e-13
Identities = 36/103 (34%), Positives = 64/103 (62%), Gaps = 2/103 (1%)
Query: 308 ERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ 367
ER+ FL L+ FM+ RGTPIN+ P++ + L+L+ L++LV + GG I + +W+++ +
Sbjct: 217 ERKEFLDDLFVFMQKRGTPINRIPIMAKQILDLYMLYKLVTEKGGLVEIINKKIWREITK 276
Query: 368 DLGIPVLNSAAGYNVKCAYKKYLYGF--EEYCRSANIEFQMAL 408
L +P ++A + ++ Y KYLY + E+ S+ E Q A+
Sbjct: 277 GLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQAAI 319
>gi|4885193 AT rich interactive domain 3A (BRIGHT- like) protein
[Homo sapiens]
Length = 593
Score = 72.0 bits (175), Expect = 3e-12
Identities = 30/87 (34%), Positives = 56/87 (64%)
Query: 308 ERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQ 367
+R+ FL L+ FM+ RGTP+N+ P++ + L+LF L+ LV + GG + + +W+++ +
Sbjct: 240 KRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITK 299
Query: 368 DLGIPVLNSAAGYNVKCAYKKYLYGFE 394
L +P ++A + ++ Y KYLY +E
Sbjct: 300 GLNLPTSITSAAFTLRTQYMKYLYPYE 326
Score = 33.5 bits (75), Expect = 1.3
Identities = 19/36 (52%), Positives = 22/36 (61%), Gaps = 3/36 (8%)
Query: 271 EDSSSSEAEEEEEE---EDDEKEKEDNSSEEEEEIE 303
ED EEE EE ED+E+E+ED EEEEE E
Sbjct: 121 EDMKPKWEEEEMEEDLGEDEEEEEEDYEDEEEEEDE 156
Score = 33.1 bits (74), Expect = 1.7
Identities = 13/29 (44%), Positives = 20/29 (68%)
Query: 265 WKTELKEDSSSSEAEEEEEEEDDEKEKED 293
W+ E E+ + EEEEE+ +DE+E+ED
Sbjct: 127 WEEEEMEEDLGEDEEEEEEDYEDEEEEED 155
Score = 31.6 bits (70), Expect = 4.9
Identities = 12/26 (46%), Positives = 20/26 (76%)
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKED 293
E++ED E EEEE+ ED+E+E+++
Sbjct: 131 EMEEDLGEDEEEEEEDYEDEEEEEDE 156
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 69.7 bits (169), Expect = 2e-11
Identities = 114/626 (18%), Positives = 224/626 (35%), Gaps = 32/626 (5%)
Query: 595 KLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDH 654
K D +D+ +SD+++ +S + ++ SS DS D + D D++ S
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 655 LTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEV 714
+++ +D S +S S + +K +D S S S + D S+ +D
Sbjct: 606 DSSDSSDS-SDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664
Query: 715 TKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNS 774
+ D D++D SS +++ S + + +S +SSNS
Sbjct: 665 SSDSSD-SSDSSDSSSSSDSSNSSDSSDSSDS--SNSSESSDSSDSSDSDSSDSSDSSNS 721
Query: 775 SSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSR 834
+S + + + + + + + S + S S+ ++ +NS + +S
Sbjct: 722 NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS----SDSSDSSDS-----SNSSDSSDSSD 772
Query: 835 AKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSP 894
+ D D +S + SDS + +S + + + +S + + + S S
Sbjct: 773 SSDSSDSSNSSDSNDSSNSSDS--SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830
Query: 895 SVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSR 954
+ DS + + + +++ +S +S + + +S S E S
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890
Query: 955 QQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSS 1014
S S + + + +DS+ DS S + S D+S SS S
Sbjct: 891 SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950
Query: 1015 SNQPEPEH-PEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELS 1073
SN + + + + + ++ SS S + ++ +NSSDS + S
Sbjct: 951 SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010
Query: 1074 AGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSF 1133
+ S S S+ S S + S + D + SN S
Sbjct: 1011 DSSDSSNS----SDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD-----SS 1061
Query: 1134 QMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSS 1193
SD + + + + + + S S +S S ++ SS S
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSE-------SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1114
Query: 1194 SPSSSSITAAVMLTLAEPSMSSASQN 1219
S SS S ++ ++ S SS S N
Sbjct: 1115 SDSSDSSNSSDSSDSSDSSDSSDSSN 1140
Score = 66.2 bits (160), Expect = 2e-10
Identities = 111/649 (17%), Positives = 211/649 (32%), Gaps = 32/649 (4%)
Query: 468 SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDD-DTTRVDESLNIKVEAEEEKAK 526
S SK + +S SD + + + +++ D+ D D++ S + ++ +
Sbjct: 619 SSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSS 678
Query: 527 SGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQT 586
S D +D N + D D S + S +
Sbjct: 679 SSSDSSNSSDSSDSSDSSNSSESS---------DSSDSSDSDSSDSSDSSNSNSSDSDSS 729
Query: 587 NPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNG 646
N S S + +SD+++ +S + S S++ S+ D + D +++
Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789
Query: 647 KEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSED 706
D ++ + S +S S ++ +D S S S + S D
Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD---SSNSSDSSDSSNSSDSSDSSD 846
Query: 707 TDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESL 766
+ D + R D + S + S + + +S
Sbjct: 847 SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSS 906
Query: 767 CMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNS 826
NSS+SS + ++ + N + S + S S + N+S
Sbjct: 907 DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966
Query: 827 DERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTV 886
D +S + D D +S SDS + +S + + + +S +
Sbjct: 967 DS--SDSNSSDSSDSSNS--------------SDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010
Query: 887 AEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSS 946
+S + S N + + +D SS S++ ++ ++ S SS
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1070
Query: 947 VTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGF 1006
+ SS + + N + +DS+ DS S + S
Sbjct: 1071 DSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1130
Query: 1007 DASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNS 1066
D+S SS SSN + ++ + D+ SS S + N+ ++S
Sbjct: 1131 DSSDSSDSSNSSDSSDSSES-SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189
Query: 1067 SDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKD 1115
SDS + S +S S S + S S+ S + S N D
Sbjct: 1190 SDSSDSS--DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Score = 65.9 bits (159), Expect = 2e-10
Identities = 158/808 (19%), Positives = 282/808 (34%), Gaps = 110/808 (13%)
Query: 456 EDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDD---KDDDTTRVDE 512
+DE E N K S + K E + + + +I + D++ D K+D VD
Sbjct: 261 DDEDEEAGNGKDSSNNSKGQ-EGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDG 319
Query: 513 SLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHR--KKIKNKLDKE-------- 562
K E+ +G E + +I ++ K+ HR K+++N++ KE
Sbjct: 320 DKTSK----SEENSAGIPEDNGSQRI-----EDTQKLNHRESKRVENRITKESETHAVGK 370
Query: 563 -KDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEI------- 614
+DK + + R ++K + N E + + K + + + I
Sbjct: 371 SQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKS 430
Query: 615 -----TSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQN 669
N S S DS D++ Q D N +ES N ND + E N
Sbjct: 431 EPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDES-------NGNDDANSESDN 483
Query: 670 SSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKS 729
+SS + ++D KD S+ E+D+ D DT +
Sbjct: 484 NSSSRGDASYNSDE-------------SKDNGNGSDSKGAEDDD-----SDSTSDTNNSD 525
Query: 730 SKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTP 789
S G ++ K+ S GK + + + +S NSS+SS D + +
Sbjct: 526 SNGNGNNGN------DDNDKSDS-GKGKSDSSDSDSSDSSNSSDSSDSSDSDSS------ 572
Query: 790 TKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQW 849
+ S + S S+ ++ +NS + +S + D D S +
Sbjct: 573 --------DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 850 PKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSK 909
+ SDSD+++ +S + + ++ S + + S S + DS
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD---------SSDSS 675
Query: 910 PIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQ 969
+ N + S SNS ++ + S ++ S SS + S + +
Sbjct: 676 DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Query: 970 EEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTG 1029
+ S S S S + + D + +SS + D+S SS SSN + +
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS-DSSDSSDSSNSSDSNDSSNSSDS 794
Query: 1030 QKRVKDAQGGGSS----------SKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESIT 1079
+ SS S S + ++ ++SSDS + S G
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 1080 KSQPVKSVSTGMKSHSTKSPARTQSPGKCGKN-GDKDPDLKEPSNRLPKVYKWSFQMSDL 1138
S S ++ S S+ S + S N D + SN S SD
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 1139 ENMTSAERITILQEKLQEIRKHYLSLKSEVA-------SIDRRRKRLKKKERESAATSSS 1191
+ +++ + S S+ + S D +S+ ++SS
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974
Query: 1192 SSSPSSSSITAAVMLTLAEPSMSSASQN 1219
SS SS+S ++ ++ S SS S N
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002
Score = 62.0 bits (149), Expect = 3e-09
Identities = 105/642 (16%), Positives = 209/642 (32%), Gaps = 50/642 (7%)
Query: 483 SDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPA 542
SD N + D+ + D D + D S + +++ + D +D
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSS-DSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSD 748
Query: 543 DKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRL-----SKPPFQTNPSPEMVSKLD 597
N N D D S + S ++ S + + D
Sbjct: 749 SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD 808
Query: 598 LTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTN 657
+D+ +S + + +S + S +S++ S+ D D D++ + +S ++
Sbjct: 809 SSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSS 868
Query: 658 NRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKK 717
+ +D + + + SS E+ +D S S S + D S+ +D + +
Sbjct: 869 DSSDSSNSSDSSDSSDSNESSNSSD---SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925
Query: 718 RKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSD 777
+ ++ S + S + + S +SSNSS
Sbjct: 926 SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985
Query: 778 EDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKD 837
D ++ + N + S + S S +NS + +S + D
Sbjct: 986 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS----------SNSSDSSNSSDSSD 1035
Query: 838 RKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVE 897
D S SDS + +S + + + +S + +S S
Sbjct: 1036 SSDSSDSSDS-----------SDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Query: 898 LEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQS 957
+ N + + +D SS S+ N+ ++ S SS + + S
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144
Query: 958 SVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQ 1017
S + E +DS+ DS S+ + S D+S SS SS+
Sbjct: 1145 S---------DSSESSDSSDSSDSSDSSDS---------SDSSDSSDSSDSSNSSDSSDS 1186
Query: 1018 PEPEHPEKA--CTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAG 1075
+ + + D+ SS S + ++ + ++SSDS + S
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246
Query: 1076 ESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPD 1117
+ + S S + +S ++++S D D D
Sbjct: 1247 SNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSD 1288
Score = 61.6 bits (148), Expect = 4e-09
Identities = 104/646 (16%), Positives = 204/646 (31%), Gaps = 41/646 (6%)
Query: 483 SDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKI-VRP 541
SD + D+ N D D + + S E+ + S D +D
Sbjct: 669 SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS-----ESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 542 ADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDA 601
+D + N D D S + S ++ S + D +D+
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD----SSDSSNSSDSSDSSDSSDSSDS 779
Query: 602 KNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRND 661
NS ++ S +S+SS + + + D++ +S + +++ N
Sbjct: 780 SNSSDSNDSS----------NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829
Query: 662 LISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDV 721
S + NSS +D S S S R D S+ +D + + D
Sbjct: 830 SDSSDSSNSSD-------SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS 882
Query: 722 KKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEE 781
+S ++ + + + + ES ++SNSS +
Sbjct: 883 SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942
Query: 782 ETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDV 841
++ + + S + S S+ ++ +NS + +S + D D
Sbjct: 943 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS-----SNSSDSSDSSDSSDSSDS 997
Query: 842 WSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKP 901
S + SDS + +S + + + +S + +S S +
Sbjct: 998 SDSSNSSDSSDS-----SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 902 PPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTV 961
N + + +D SS S+ ++ ++ S SS + SS +
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1112
Query: 962 SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPE 1021
+ + +DS+ DS SE + S D+S SS SS+ +
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172
Query: 1022 HPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKS 1081
+ D+ SS S + ++ ++SSDS + S + S
Sbjct: 1173 DSSDSSNS----SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1228
Query: 1082 QPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPK 1127
S S + + + + D D + S+ K
Sbjct: 1229 SDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSK 1274
Score = 61.2 bits (147), Expect = 6e-09
Identities = 125/623 (20%), Positives = 226/623 (36%), Gaps = 42/623 (6%)
Query: 619 NGLQASESSAEDSEQEDERG-AQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLE-- 675
NG E ++++E G +D NN K + DH + +D + +S +
Sbjct: 249 NGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPE 308
Query: 676 -----ENKVHADLVISK-------PVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKK 723
N+V D P +R+ ++ ++ E+ +TK+ +
Sbjct: 309 GKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKE-SETHA 367
Query: 724 DTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEET 783
+ +IK N + + G+ G KE+K ++ L N + E
Sbjct: 368 VGKSQDKGIEIKGPSSGNRNITKEVGKGNEG-KEDKGQHGMILGKGNVKTQGEVVNIEGP 426
Query: 784 KAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWS 843
K P K G + G+ S + + N+SDE N A D S
Sbjct: 427 GQKSEPGNKV-GHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNS 485
Query: 844 SIQG--QWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKP 901
S +G + K+ + SD++ A + + +S + + K
Sbjct: 486 SSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKG 545
Query: 902 PPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPT-TPESPSSVTVTEGSRQQSSVT 960
+ DS + + ++ SS SNS ++ + + S SS + + S S +
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 961 VSEPLAPNQEEVRSIKSETDST-IEVDSVAGELQDLQSEGNSSPA--GFDASVSSSSSNQ 1017
S + + + S S++DS+ E DS + + S+ NSS + D+S SS+SSN
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 1018 PEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGES 1077
+ + D+ SS S + N+ + ++SSDS+ + +S
Sbjct: 666 SDSSDSSDS-------SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDS 718
Query: 1078 ITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSD 1137
+ S S S+ S S + S N D + SN S SD
Sbjct: 719 -SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSN--------SSDSSD 769
Query: 1138 LENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSS 1197
+ + + + + S S S D +S+ + SS+SS SS
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSN--SSDSSNSSDSSDSSDSSDSDSSNSSDSS 827
Query: 1198 SSITAAVMLTLAEPSMSSASQNG 1220
+S ++ ++ S SS S +G
Sbjct: 828 NSSDSSDSSNSSDSSDSSDSSDG 850
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 66.2 bits (160), Expect = 2e-10
Identities = 158/772 (20%), Positives = 300/772 (38%), Gaps = 108/772 (13%)
Query: 410 EKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNII----PREEKPI---EDEIERK 462
E + ++ K + I + ET+ +++K + ER+ I P+++K E +++
Sbjct: 647 ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
Query: 463 ENIKPSLGS-KKNLLESIPTHSDQEK-----EVNIKKPEDNENLDDKDDDTTRVDESLNI 516
++ P L S K ++S ++EK ++++K + + D+T +
Sbjct: 707 DSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGL 766
Query: 517 KVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIK-NKLDKEKDKDEKYSPKNCK 575
KV EE K + +D DK K KHR + K + L K+ +Y K +
Sbjct: 767 KV--EENIQKQSQQTKLSSD------DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE 818
Query: 576 LRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQED 635
R + S E +K + ++SD + I+ + S +G+ S SE +
Sbjct: 819 NVRKENNKKERRLSAEK-TKAEHKSRRSSD-SKIQKDSLGSKQHGITLQRRSESYSEDKC 876
Query: 636 ERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPER 695
+ + +MD+N K E +++ KE++ + SLLEE ++ K SK+ +
Sbjct: 877 DMDSTNMDSNLKPE-----------EVVHKEKRRTKSLLEEK------LVLKSKSKTQGK 919
Query: 696 LRKDIEVLSEDTDYEEDEVTK--KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSP 753
K +E ++ ++ K K K+ +++ ++K K +++ E L+T S
Sbjct: 920 QVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASS 979
Query: 754 G----KKEEKAKNKESLCMENSSNSSSDEDEEETKAK-------MTPTKKYNGLEEKRKS 802
+K+ + K L E SD+D T+ + + + K++ + K+K
Sbjct: 980 SAHSTQKDSSHRAKLPLAKE---KYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKD 1036
Query: 803 LRTTGFYSGFSEVAEKRIKLLNNS---DERLQNSRAKDRKDVWSSIQGQWPKKTLKELFS 859
+ G EV K NS +++L ++R+ S + +K S
Sbjct: 1037 ENKSDDKDG-KEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLS 1095
Query: 860 DSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKP-------PPVNVDSKPIE 912
+ P + E+ + E E+ K ++DS+ ++
Sbjct: 1096 TPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMK 1155
Query: 913 EKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSV------------TVTEGSRQQSSVT 960
+KT +K E + ++S P P + V T+T+ QS+V+
Sbjct: 1156 QKT-SATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVS 1214
Query: 961 -----VSEPLAPNQEEVRSIKSET------DSTIEVDSVAGELQDLQSEGNSSPAGFDAS 1009
EP+ EV +I SET + E D V L++ +E + +
Sbjct: 1215 KMNPGEKEPIHRGTTEV-NIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATLE 1273
Query: 1010 VSSSSSNQP-----------EPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNK 1058
S++ + P E P+ KR +G +S+ S
Sbjct: 1274 HSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTV-LEGSTASTSPADHSALPNQSLTV 1332
Query: 1059 KKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGK 1110
++ + +SDS+E GE T P K+ T K H ++ T GK GK
Sbjct: 1333 RESEVLKTSDSKE--GGEGFTVDTPAKASITS-KRHIPEAHQATLLDGKQGK 1381
Score = 55.8 bits (133), Expect = 2e-07
Identities = 155/792 (19%), Positives = 274/792 (34%), Gaps = 146/792 (18%)
Query: 436 IKEIK-MEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEV----- 489
++EIK +E N + K ++ E ++N G KK ++KE
Sbjct: 287 VEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKF 346
Query: 490 -NIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAK---------------------- 526
+ KK ED + + D+ + ESL + E KAK
Sbjct: 347 DHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDI 406
Query: 527 ----------SGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKL 576
S ++E + +++V +I + KNK +K K + S K
Sbjct: 407 TVSSVHTSDLSSFEEDTE-EEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKS 465
Query: 577 RR---LSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQ 633
R + KP + + +L + + S E L Q + E+ +
Sbjct: 466 VRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAK-----EKEERLLRRQINREKLEEKRK 520
Query: 634 EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSP 693
+ + G+ S +D L + + + +L+E K V+ K V+ S
Sbjct: 521 QKAEKTKSSKTKGQGRSSVD-LEESSTKSLEPKAARIKEVLKERK-----VLEKKVALSK 574
Query: 694 ERLRKDIEVLSEDT----DYEED--EVTKKRKDVKKDTTDKS-------SKPQIKRGKRR 740
+R +KD + E++ YEED E K + +K+ S +K + + RR
Sbjct: 575 KR-KKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARR 633
Query: 741 YCNTEECL---KTGSPGKKEEKAKNKESLCMENSSNSSSDED-----EEETKAKMTPTKK 792
+ + K S ++E K + + ME + D E P K+
Sbjct: 634 LSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQ 693
Query: 793 YNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKK 852
+ L+ ++ + + +K +K ER + + ++D+ V +G K
Sbjct: 694 KSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPER-EKTPSEDKLSVKHKYKGDCMHK 752
Query: 853 TLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVA----EEESCSPSVELEKPPPVNVDS 908
T +TE +S EE + ++S QT + E S K + D
Sbjct: 753 T------GDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDG 806
Query: 909 KPIEEKTVEVNDR-----------------KAEFPSSGSNSVLNTPPTTPESPSSVTVTE 951
KP+ E ++ ++ KAE S S+ + +T+
Sbjct: 807 KPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQR 866
Query: 952 GSRQQS-------SVTVSEPLAPNQEEVRSIKSETDSTIE---------------VDSVA 989
S S S + L P +E V K T S +E V V
Sbjct: 867 RSESYSEDKCDMDSTNMDSNLKP-EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVE 925
Query: 990 GELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKA------CTGQKRVKDAQGGGSSS 1043
ELQ+ ++ ++P ++ N E + K TG + V + + S
Sbjct: 926 TELQEGATKQATTPK--PDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHS 983
Query: 1044 KKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQ 1103
++ SH+A + K+K K S S L + +S G KS S K ++
Sbjct: 984 TQKDSSHRAKLPLAKEKYKSDKDSTSTRLE-----------RKLSDGHKSRSLKHSSKDI 1032
Query: 1104 SPGKCGKNGDKD 1115
K+ DKD
Sbjct: 1033 KKKDENKSDDKD 1044
Score = 46.2 bits (108), Expect = 2e-04
Identities = 73/386 (18%), Positives = 155/386 (40%), Gaps = 75/386 (19%)
Query: 439 IKMEEERNI--IPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPED 496
+ + E N+ I EE P+ N+ L K NL S++EK I P +
Sbjct: 2640 VTVSSEENVCDIGNEESPL--------NVLGGLKLKANLKMEAYVPSEEEKNGEILAPPE 2691
Query: 497 N------ENLDDKDDDTTRVDESLNIK---VEAEEEKAKSGYDEW--------------- 532
+ + + + V+ESLN++ EE Y++
Sbjct: 2692 SLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISG 2751
Query: 533 --IKAD-KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPS 589
++AD K V ++++PK RK+ ++ L E + D+ + ++ + +T P
Sbjct: 2752 HSVEADPKEVEEEERHMPK---RKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPH 2808
Query: 590 PEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEE 649
D K ++ ++ + TS + + +++ E++DE + + E+
Sbjct: 2809 ----------DTKEENSRDLEELPKTSS----ETNSTTSRVMEEKDEYSSSETTGEKPEQ 2854
Query: 650 SKIDHLTNNRND--LISKEE---------QNSSSLLEENKVHADLVISKPVSKSPERLRK 698
+ D + + D +I K + + + + +++K +V V +SP +
Sbjct: 2855 NDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVT---VEQSPSSSK- 2910
Query: 699 DIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKR--RYCNTEECLKTGSPGKK 756
++V+ D +E ++R D +K +RG++ R + ++ P +K
Sbjct: 2911 -LKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERK 2969
Query: 757 EEKAKNKESLCMENSSNSSSDEDEEE 782
+K+ + +E+ SDE+EEE
Sbjct: 2970 RQKSVSDP---VEDKKEQESDEEEEE 2992
Score = 31.2 bits (69), Expect = 6.3
Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 6/42 (14%)
Query: 269 LKEDSSSSEAEEEEEE------EDDEKEKEDNSSEEEEEIEP 304
+ +D+ SSE E + ++ ED ++++ D EEEEE EP
Sbjct: 2957 VSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEP 2998
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 65.1 bits (157), Expect = 4e-10
Identities = 130/649 (20%), Positives = 238/649 (36%), Gaps = 154/649 (23%)
Query: 265 WKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRG 324
W+ E + + A+EEE ++++ + + EE E +RE +++ K + R
Sbjct: 1758 WQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817
Query: 325 TPIN------KRPVLGYRNLNL----------------------FKLFRLVH-------- 348
IN K ++ Y+ NL + RL H
Sbjct: 1818 RWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQV 1877
Query: 349 --KLGGFDNI----------ESGAVWKQVY-----QDLGIPVLNSAAGYNVKCAYKKYLY 391
KLG F+ I E V K+ + + V +S A K A +K
Sbjct: 1878 KNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKL 1937
Query: 392 GFEEYC----RSANIEFQMALPEKVVNKQCKEC--ENVKEIKVKE--------------- 430
E+ + E +A EK +N + K E ++ ++ KE
Sbjct: 1938 ALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRK 1997
Query: 431 --ENETEIKEIKMEEERNIIPREEKPI---EDEIERKE------------------NIKP 467
+ E E+ E K+ E I+ E++ + E EI + +
Sbjct: 1998 MTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASR 2057
Query: 468 SLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE-EKAK 526
L K+ L P ++ + K D L ++ T++ +L +K E++K
Sbjct: 2058 KLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSK 2117
Query: 527 SGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQT 586
EW ++K + ++K+ NK+ + +K+EK + + KL R
Sbjct: 2118 LDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKH------ 2171
Query: 587 NPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNG 646
S++ L D + I+ E+ L A+ ++ E+ + +D
Sbjct: 2172 -------SEVILDDEEEGG---IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVE 2221
Query: 647 KEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSED 706
EE H + L+ + E+ S EE + + + E +R++ E E+
Sbjct: 2222 SEE----HFSEEMESLLDELEKQESLSSEEEEEREE-----EEEREEEEVREEEEERKEE 2272
Query: 707 TDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESL 766
+ EE +V K+ ++ KK +K K +++ +KEE + KE +
Sbjct: 2273 EEGEEKQVEKEEEEKKKKKKEKK-KEEVQ-------------------EKEEVFEEKEEI 2312
Query: 767 CMENSSNSSSDEDEEE-----------TKAKMTPTKKYNGLEEKRKSLR 804
E + S SDE+EEE K + K++ E++RKSLR
Sbjct: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLR 2361
Score = 45.8 bits (107), Expect = 2e-04
Identities = 112/546 (20%), Positives = 232/546 (42%), Gaps = 61/546 (11%)
Query: 265 WKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKF--MED 322
WK ++ E+ SS+++E++ ++++E E+ S E EE E E + +Q+ +K+ +
Sbjct: 1521 WK-QVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHR 1579
Query: 323 RGTPINKRPVLGYRNL--NLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGY 380
+ K+ R L KL + +L + + A K D A
Sbjct: 1580 KRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDD------REMAQA 1633
Query: 381 NVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIK 440
K A K+ E + Q A EK+ K+ K + +++ +EE + K K
Sbjct: 1634 EGKFAQKE-----ETLAQRGEKLSQEA--EKLAQKRKKLAKKWEKV-AREEEKLAKKGGK 1685
Query: 441 MEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENL 500
+ E +NI+ ++ +E+ +R++N+ +K L + + +E++ K+ E N+
Sbjct: 1686 LAEVKNILAQK---VEELPQREQNLD---WQEKELAQELEELEWDMEELSWKEEELNQ-- 1737
Query: 501 DDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 560
++ V+E + AEEE+A + E + ++ + A + I+ ++K+ +
Sbjct: 1738 ----EEGKLVEEKKKL---AEEEEALAWQREKLSEEE-TKLAQEEELLIQEKEKLAQHKE 1789
Query: 561 KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNG 620
K +++E+ K +L K + S +LT KN + K N
Sbjct: 1790 KMPEEEERLGRKREQLIE-KKMKLAQKRERWINSMEELT--KNKMILYQKK-------NL 1839
Query: 621 LQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVH 680
Q ++ A++ E+ +R + N + LT+++ L+ Q + L NK+
Sbjct: 1840 AQEKKNLAQEKEKLAQRKENLLYNK-------ERLTHSKKQLV----QVKNKLGMFNKIL 1888
Query: 681 ADLVISKPVSKSPERLRKDIEVLSEDTD---YEEDEVTKKRKDVKKDTTDKSSKPQIKRG 737
A + + +++ E + K E L+E ED + KK++ + ++ + + + +G
Sbjct: 1889 AQ--VEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQG 1946
Query: 738 KRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLE 797
K+R + K E K +E + + + S + ET + T+ L
Sbjct: 1947 KKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELF 2006
Query: 798 EKRKSL 803
E++ SL
Sbjct: 2007 ERKLSL 2012
Score = 43.5 bits (101), Expect = 0.001
Identities = 79/456 (17%), Positives = 181/456 (39%), Gaps = 58/456 (12%)
Query: 424 KEIKVKEENETEIKEIK-----MEEERNI------IPREEKPIEDEIERKENIKPSLGSK 472
KEI KEE +T K K +++ER + + +EE+ + +E+E ++ + +
Sbjct: 1385 KEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQ 1444
Query: 473 KN---LLESIPT--------------HSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLN 515
+ ++E P+ H + K K E + L +++ + E L+
Sbjct: 1445 EGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLS 1504
Query: 516 IKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCK 575
+ E +E K ++EW + + + + + K +++ + + ++ +EK +
Sbjct: 1505 PEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEE 1564
Query: 576 LRRLS----------KPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASE 625
R + K + KL + K + + E +
Sbjct: 1565 QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKIT 1624
Query: 626 SSAEDSEQEDERGAQDMDNNGKEESKI----DHLTNNRNDLISKEEQ---NSSSLLEENK 678
+ Q + + AQ + + K+ + L R L K E+ L ++
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGG 1684
Query: 679 VHADL--VISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKR 736
A++ ++++ V + P+R ++ D++E E+ ++ ++++ D + S K + +
Sbjct: 1685 KLAEVKNILAQKVEELPQR--------EQNLDWQEKELAQELEELEWDMEELSWKEE-EL 1735
Query: 737 GKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGL 796
+ EE K ++E A +E L E + + +E + K K+ K+
Sbjct: 1736 NQEEGKLVEEKKKLAE--EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPE 1793
Query: 797 EEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQN 832
EE+R + ++A+KR + +N+ +E +N
Sbjct: 1794 EEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN 1829
Score = 36.2 bits (82), Expect = 0.20
Identities = 108/541 (19%), Positives = 188/541 (34%), Gaps = 82/541 (15%)
Query: 674 LEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQ 733
+EE V++ S V K L KD++ +D + +T KR +D DK +
Sbjct: 1131 MEEASVYSQWSSSTSVIK----LSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKA--- 1183
Query: 734 IKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKY 793
T KK+ K K KE+ + N + ++ TK +
Sbjct: 1184 ----------------TAQKLKKKHKKKGKEAKVI-NEETTPPVMEQPVTKKVKIQGRGA 1226
Query: 794 NGLEEKRKSLRTTGFYSGFSE---------VAEKRIKLLNNSDERL---QNSRAKDRKDV 841
+G+ +R T G S + + ++ + K+ N + L DR
Sbjct: 1227 SGISGRRS---TAGDGSSWRDDLCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPS 1283
Query: 842 WSSIQGQWP--KKTLKELFSDSDTEAAASPPHPAP----EEGVAEESLQTVAEEESCSPS 895
W Q P KK K L D D + PP P E + E+ +Q V +E
Sbjct: 1284 WELFQEICPLLKKESKVLLEDLDWDVV--PPEKKPIFIQEGAIREDMIQGVTQEVIRHKE 1341
Query: 896 V---ELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEG 952
V E E+ D +EE V + K N + + E + +
Sbjct: 1342 VMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKTF---QK 1398
Query: 953 SRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAG-ELQDLQSEGNSSPAGFDASVS 1011
S +Q V + + + K E D + EV+ +A E + ++ EG
Sbjct: 1399 SPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGK----------L 1448
Query: 1012 SSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEE 1071
P + +KA K+V + K++ + K G S EE
Sbjct: 1449 VMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEE 1508
Query: 1072 LSAGESITKSQPVKSV-----STGMKSHSTKSPARTQSPGKCGKNG-DKDPDLKEPSNRL 1125
+ + K + K V S+ K K + + G +K+ + E +
Sbjct: 1509 MLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHI 1568
Query: 1126 PKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERES 1185
+ +KW+ +R +++ QE RK L E + + ++L ++ER+
Sbjct: 1569 QEEHKWA--------RIHRKRARAEKKRAQEERK----LAQEEEKLAQEERQLAQEERKL 1616
Query: 1186 A 1186
A
Sbjct: 1617 A 1617
Score = 35.0 bits (79), Expect = 0.44
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Query: 253 LEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDN--SSEEEEEIEPFPEERE 310
LE +S + + E +E+ E EEEEE +E+E E+ EEEE+ + E+++
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
Query: 311 NFLQQLYKFMEDR 323
+Q+ + E++
Sbjct: 2297 EEVQEKEEVFEEK 2309
Score = 33.9 bits (76), Expect = 0.98
Identities = 21/66 (31%), Positives = 32/66 (48%)
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEP 304
LK+ + + E + + +++ E S EE E DE EK+++ S EEEE
Sbjct: 2193 LKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEERE 2252
Query: 305 FPEERE 310
EERE
Sbjct: 2253 EEEERE 2258
Score = 33.1 bits (74), Expect = 1.7
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 3/92 (3%)
Query: 227 RKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEED 286
R++ E + + V K+ E+ + + + K E+ E+ +EEE E
Sbjct: 2263 REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLS 2322
Query: 287 DEKEKEDNSSEEEE---EIEPFPEERENFLQQ 315
DE+E+E++ S EEE E E +E++ LQ+
Sbjct: 2323 DEEEEEESCSLEEEVDREKEILKKEKQFKLQE 2354
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 65.1 bits (157), Expect = 4e-10
Identities = 199/1035 (19%), Positives = 372/1035 (35%), Gaps = 133/1035 (12%)
Query: 223 TSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTE---LKEDSSSSEAE 279
T P+K H I SDT+ + DA + + L +P + E K+ ++ +
Sbjct: 396 TIAPKKASHRILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVK 455
Query: 280 EEEEEEDDEKE--------KEDNSSEEEEEIEPFPEERENFLQQ--------------LY 317
++ ++E +E K +S E E E ++R++ L+
Sbjct: 456 KKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLF 515
Query: 318 KFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQV--YQDLGIPVLN 375
+ T + +N + + + I S A W +V D L
Sbjct: 516 SSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPA-WSEVSSLSDSTRTRLT 574
Query: 376 SAAGYNVKCAYKKYLYGF---EEYCRSANIEFQ----MALPEKVVNKQCKECENVKEIKV 428
S + Y+ + + + L +E+ + A++ + ++ E V K KE + VK+ K
Sbjct: 575 SESDYSSEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKT 634
Query: 429 KEENETEIK---EIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNL--LESIPTHS 483
K +++ + K I E + E + + + ++ ++ L ++ L L+ H
Sbjct: 635 KHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHF 694
Query: 484 DQEKEVNIKKPEDNENLDDKDDDTTRV-DESLNIKVEAEEEKAKSGYDEWIKADKIVRPA 542
+E++++ K E+ E L + R+ D + +I EEK +S E ++ K P
Sbjct: 695 KKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPK 754
Query: 543 DKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAK 602
++ + K +K K+K D+ ++K K K+ + + F+ E KL
Sbjct: 755 EEKLRLYKEERKKKSK-DRPSKLEKKNDLKEDKISKEKEKIFK-----EDKEKLKKEKVY 808
Query: 603 NSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDL 662
D+A + L S ++D D + K E D + D+
Sbjct: 809 REDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDM 868
Query: 663 ISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVK 722
S A L++ S ER R+D E DY E KK +D
Sbjct: 869 KSDSV-------------AKLILETVKEDSKER-RRDSRA-REKRDYREPFFRKKDRDYL 913
Query: 723 KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEE 782
++K K Q ++ K PG EK K + S+ + D +
Sbjct: 914 DKNSEKR-KEQTEKHK------------SVPGYLSEKDKKRRE-----SAEAGRDRKDAL 955
Query: 783 TKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVW 842
K + E R+ L+ G SGF + ++ ER +R K++KD
Sbjct: 956 ESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKEKKD-- 1013
Query: 843 SSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPP 902
P K KE + +S ++ +E+S+ E C E +K
Sbjct: 1014 ------GPDKERKEKTKPERYKEKSS------DKDKSEKSIL-----EKCQKDKEFDKCF 1056
Query: 903 PVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVS 962
D+K + T + + G P S + ++ S ++
Sbjct: 1057 KEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIA 1116
Query: 963 EPLAPNQEEVRSIKSETDSTIEVDSVAGELQDL-QSEG-NSSPAGFDASVSSSSSNQPEP 1020
+ E+ R DS + GE DL +++G G +A S +
Sbjct: 1117 DIFTDESEDDR------DSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDK 1170
Query: 1021 EHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDS-EELSAGESIT 1079
+HPE+ + R + G + + + K K V K+ K S++ ++ S+
Sbjct: 1171 QHPERQKDKEPRDRRKDRGAADAGRDK---KEKVFEKHKEKKDKESTEKYKDRKDRASVD 1227
Query: 1080 KSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLE 1139
+Q K+ + K A ++ K + DK+ + S+R K + LE
Sbjct: 1228 STQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEK--SLLEKLE 1285
Query: 1140 NMTSAERITILQEKLQEIRKHYLSLKSEVASI--------------DRRRK------RLK 1179
E +K+ E+ + + + + D+ R+ +LK
Sbjct: 1286 EEALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLK 1345
Query: 1180 KKERESAATSSSSSS 1194
+KER ++SSS S
Sbjct: 1346 EKERHRHSSSSSKKS 1360
Score = 50.8 bits (120), Expect = 8e-06
Identities = 210/1024 (20%), Positives = 371/1024 (36%), Gaps = 177/1024 (17%)
Query: 215 RSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSS 274
RSF++ K S + + + +PK + L+ E+ + K R K +LKED
Sbjct: 730 RSFREEKDRS-NKAEKERSLKEKSPKEEK-LRLYKEERKKKSKDRPSKLEKKNDLKEDKI 787
Query: 275 SSEAEE--EEEEEDDEKEK---EDNSSEE--------EEEIEPF---PEERENFLQQLYK 318
S E E+ +E++E +KEK ED++ +E E E F ++R+ + L
Sbjct: 788 SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDDQRDRWFSDLSD 847
Query: 319 FMED-RGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIE----SGAVWKQVY------- 366
D +G PV YR++ + +L+ + D+ E S A K+ Y
Sbjct: 848 SSFDFKGEDSWDSPVTDYRDMKSDSVAKLILETVKEDSKERRRDSRAREKRDYREPFFRK 907
Query: 367 QDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEI 426
+D NS +K E + + K + CKE + +
Sbjct: 908 KDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRDRKDALESCKERRDGR-A 966
Query: 427 KVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQE 486
K +E + E+KE E + + +E E P+ +K D+E
Sbjct: 967 KPEEAHREELKECGCES--GFKDKSDGDFGKGLEPWERHHPAREKEKK------DGPDKE 1018
Query: 487 KEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNV 546
++ K E DKD + ++S+ K + ++E +D+ K K + K+
Sbjct: 1019 RKEKTKPERYKEKSSDKD----KSEKSILEKCQKDKE-----FDKCFKEKKDTKEKHKDT 1069
Query: 547 -PKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSD 605
K K RK LD+ K+K EK P ++S+ D ++ K+
Sbjct: 1070 HGKDKERKA---SLDQGKEKKEK-------------------AFPGIISE-DFSEKKDDK 1106
Query: 606 TAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISK 665
KS I I E ED+R +G + + L + L K
Sbjct: 1107 KGKEKSWYIADIFT-----------DESEDDR--DSCMGSGFKMGEASDLPRT-DGLQEK 1152
Query: 666 EEQNSSSLLEENKVHADLV-ISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKD 724
EE + + ++ +D + K P RKD D ++++V +K K+ K
Sbjct: 1153 EEGREAYASDRHRKSSDKQHPERQKDKEPRDRRKDRGAADAGRD-KKEKVFEKHKEKK-- 1209
Query: 725 TTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETK 784
DK S + K K R S ++K KNK+ L E + + ED+ ++K
Sbjct: 1210 --DKESTEKYKDRKDR----------ASVDSTQDK-KNKQKL-PEKAEKKHAAEDKAKSK 1255
Query: 785 AKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSS 844
K K+++ ++RKS R+ A+ LL +E + +D D
Sbjct: 1256 HKEKSDKEHS---KERKSSRS----------ADAEKSLLEKLEEEALHEYREDSND---- 1298
Query: 845 IQGQWPKKTLKELFSDSDTEAAASPPHPA-PEEGVAEESLQTVAEEESCSPSVELEK--- 900
+ E+ SDS T+ P A E E E +C P EK
Sbjct: 1299 --------KISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKERH 1350
Query: 901 -----PPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQ 955
+ D + +++ E ++ ++ GS + +
Sbjct: 1351 RHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRK------------------DSGQY 1392
Query: 956 QSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSV-AGELQDLQSEGNS------SPAGFDA 1008
+ ++ + I+ E D TIE+ S + D + E + P G +
Sbjct: 1393 EKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYG-SS 1451
Query: 1009 SVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKK--KGKGTNS 1066
+++ + +H EK ++R +D G R H+ ++ + + + T
Sbjct: 1452 AINILKEKKKREKHREKWRDEKERHRDRHADG-----LLRHHRDELLRHHRDEQKPATRD 1506
Query: 1067 SDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLP 1126
DS + P + + + P K DK K+P +
Sbjct: 1507 KDSPPRVLKDKSRDEGPRLGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDA 1566
Query: 1127 KVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRL---KKKER 1183
+ + DL MTS ER +L +K EI + + K + +++ R R K KE+
Sbjct: 1567 RPREKLLGDGDL-MMTSFER--MLSQKDLEIEERHKRHKERMKQMEKLRHRSGDPKLKEK 1623
Query: 1184 ESAA 1187
A
Sbjct: 1624 AKPA 1627
Score = 44.7 bits (104), Expect = 6e-04
Identities = 145/716 (20%), Positives = 244/716 (34%), Gaps = 143/716 (19%)
Query: 449 PREEKPIEDEIERKENIKPSLG--SKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDD 506
P +K E RK+ G K+ + E D+E K +D ++D D
Sbjct: 1173 PERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYKDRKDRASVDSTQDK 1232
Query: 507 TTRVDESLNIKVE---AEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKE- 562
+ + L K E A E+KAKS + E K+DK K+ K + KL++E
Sbjct: 1233 KNK--QKLPEKAEKKHAAEDKAKSKHKE--KSDKEHSKERKSSRSADAEKSLLEKLEEEA 1288
Query: 563 -----KDKDEKYS-------------PKNCKLRRLS--KPPFQTNPS-----PEMVSKLD 597
+D ++K S P +S +PP P PE + + +
Sbjct: 1289 LHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEKE 1348
Query: 598 L------TDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKE--- 648
+ K+ D K + G E + + E+ + D G
Sbjct: 1349 RHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYNM 1408
Query: 649 --------ESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDI 700
+ I+ + + D E + S + +E K + I+ + K ++ K
Sbjct: 1409 KADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAIN--ILKEKKKREKHR 1466
Query: 701 EVLSEDTD------------YEEDEVTKKRKDVKKDTT-DKSSKPQIKRGKRRYCNTEEC 747
E ++ + + DE+ + +D +K T DK S P++ + K R
Sbjct: 1467 EKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSR------- 1519
Query: 748 LKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTG 807
G + AK KE +D E K K P K NG +K + G
Sbjct: 1520 ----DEGPRLGDAKLKEKF-----------KDGAE-KEKGDPVKMSNG-NDKVAPSKDPG 1562
Query: 808 FYSGFSEVAEKRIKLLNNSDERLQN-SRAKDRKDVWSSIQGQWPKKTLKEL------FSD 860
+ A R KLL + D + + R +KD+ + + K+ +K++ D
Sbjct: 1563 -----KKDARPREKLLGDGDLMMTSFERMLSQKDLEIEERHKRHKERMKQMEKLRHRSGD 1617
Query: 861 SDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPP---PVNVDSKPIEEKTVE 917
+ A P ++G+ + +KPP P D K E +
Sbjct: 1618 PKLKEKAKPADDGRKKGL----------------DIPAKKPPGLDPPFKDKKLKESTPIP 1661
Query: 918 VNDRKAEFPSSGSNSV--LNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSI 975
P+SG++S L P P+S + S P+ EEV
Sbjct: 1662 PAAENKLHPASGADSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSYEEVMHT 1721
Query: 976 KSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQ--KRV 1033
+ A + DL FD + S S+ P P P AC+ R
Sbjct: 1722 PRTPSCS------ADDYADLV---------FDCADSQHST--PVPTAPTSACSPSFFDRF 1764
Query: 1034 KDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVST 1089
A G S + Q + + + + EE S G+ + + Q V + S+
Sbjct: 1765 SVASSGLSENASQAPARPLSTNLYRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASS 1820
Score = 33.9 bits (76), Expect = 0.98
Identities = 33/166 (19%), Positives = 67/166 (40%), Gaps = 11/166 (6%)
Query: 138 KKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVV 197
K T + H ++E +S E K ++ + K+ W+ A +
Sbjct: 1060 KDTKEKHKDTHGKDKERKASLDQGKEKKEKAFPGIISEDFSEKKDDKKGKEKSWYIADIF 1119
Query: 198 CPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSD--TAPKPDAVLKQAFEQALEF 255
+ D+ +D+ + FK G+ + +PR D + + A D K + +Q E
Sbjct: 1120 TDESEDD----RDSCMGSGFKMGEASDLPRTDGLQEKEEGREAYASDRHRKSSDKQHPER 1175
Query: 256 HKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE 301
K + + ++D +++A +++E+ EK KE E E+
Sbjct: 1176 QKDKE-----PRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEK 1216
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.1 bits (157), Expect = 4e-10
Identities = 192/978 (19%), Positives = 396/978 (40%), Gaps = 140/978 (14%)
Query: 230 VHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEK 289
+ E+ T K D +KQ ++L S + A K L+E+ S + + ++ +++ E
Sbjct: 668 IEEMNEKTLEKLD--VKQTELESLSSELSEVLKARHK--LEEELSVLKDQTDKMKQELEA 723
Query: 290 EKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHK 349
+ ++ + +++++ +E E +Q+ K ++D+ + +L R+ +L + V
Sbjct: 724 KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL--LLKERDKHLKEHQAHVEN 781
Query: 350 LGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALP 409
L D S +Q L + +A + AY++ L ++ E ++ L
Sbjct: 782 LEA-DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE-RILLT 839
Query: 410 EKVVNKQCKE---CENVKEIKVKEEN---ETEIKEIKMEEE-RNIIPREEKPIEDEIERK 462
++V + ++ C + K++ ++ + E + +ME++ +++ E +ED + +
Sbjct: 840 KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
Query: 463 ENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEE 522
E K L K+N++ + Q+KE+ I + L K+D S++I E E
Sbjct: 900 EQTKQILVEKENMI--LQMREGQKKEIEIL----TQKLSAKED-------SIHILNEEYE 946
Query: 523 EKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKP 582
K K+ +K + K+K + K + K+K D++ KL++ +
Sbjct: 947 TKFKN--------------QEKKMEKVKQKAKEMQETLKKKLLDQE-----AKLKKELE- 986
Query: 583 PFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDM 642
N + E+ K +AK + A S I+ ++ L+ ++ +S E R
Sbjct: 987 ----NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR----- 1037
Query: 643 DNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEV 702
ND+IS E+ + EE + ++ + + + E +K +
Sbjct: 1038 --------------RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Query: 703 LSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAK- 761
E + ++ K + VK+DTT + Q+K ++ S + E K K
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK---------QKSAHVNSLAQDETKLKA 1134
Query: 762 --NKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTG-FYSGFSEVAEK 818
K + + S ++ E+ + KM + + E L+TT + EK
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 819 RIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLK----EL--FSDSDTEAAASP-PH 871
K L D+ L+ + + + I + + L+ EL S S T A S H
Sbjct: 1195 SNKSL--EDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 872 PAPEEGVAEESLQ----TVAEEESCSPSVELEKPPPVNVD----SKPIEEKTVEVNDRKA 923
+E+L TV+E E+ + E+ +N+ + +EEK ++ KA
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQL-TEEQNTLNISFQQATHQLEEKENQIKSMKA 1311
Query: 924 EFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVT-VSEPLAPNQEEVRSIKSE-TDS 981
+ S L T + S ++S +T + + L+ N V +K E +
Sbjct: 1312 DIES------LVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
Query: 982 TIEVDSVAGELQDL--QSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGG 1039
+E+ S++ +L DL Q + + S + +A++SS ++ E+ C +V+D
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL-----RKQYDEEKCELLDQVQDLSFK 1420
Query: 1040 GSSSKKQK---------RSHKATVVNNKKKGKGTNSSDSE-------ELSAGESITKSQP 1083
+ K+K S+K + K + + T ++ EL + E+ K +
Sbjct: 1421 VDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQ 1480
Query: 1084 VKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTS 1143
+ + + + + K DK K+ SN ++ + ++ +LE+ +
Sbjct: 1481 INLLKEELDQQNKRFDCL-----KGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 1144 AERITILQEKLQEIRKHY 1161
+ I I E L E+ K+Y
Sbjct: 1536 QKTIEI--ESLNEVLKNY 1551
Score = 37.4 bits (85), Expect = 0.088
Identities = 94/502 (18%), Positives = 199/502 (39%), Gaps = 47/502 (9%)
Query: 266 KTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGT 325
K EL+ + S +++EEE + +++ + +++++ E ++ +QL ME++
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664
Query: 326 PINK--RPVLGYRNLNLFKLFRLVHKLGG-FDNIESGAVWKQVYQDLGIPVLNSAAGYNV 382
K L N L + R VH L ++ES Q + V SA
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS-------QSETLIVPRSAKNV-- 1715
Query: 383 KCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKME 442
AY + + C E ++++ ++ + ++ K + V + KEE + E++ +
Sbjct: 1716 -AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ--EKEETVSSHFEMRCQ 1772
Query: 443 EERNIIPREEKPIEDEIERKE--NIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENL 500
+ +I E + ++ +++ L +KN S+ EKE + +NL
Sbjct: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEEL-EEKNKKYSLIVAQHVEKEGGKNNIQAKQNL 1831
Query: 501 DDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLD 560
++ DD + + + + E+K K D + K V + K+ K +
Sbjct: 1832 ENVFDDVQKTLQEKELTCQILEQKIKE-LDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
Query: 561 KEKDKDEKYSPKNCKLR---RLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSI 617
++K + +N + + L +P +N + + L+ A EI +
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH-NDLEFKLAGAEREKQKLGKEIVRL 1949
Query: 618 LNGLQASESSAE----------DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEE 667
L+ + D E+E++ + D K S + L N ++++E
Sbjct: 1950 QKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE 2009
Query: 668 QNSSSLLEE-----NKVHADLVIS---------KPVSKSPERLRKDIEVLSEDTDYEEDE 713
Q ++E +V A+L+ S K +++ + L++ + E D E+E
Sbjct: 2010 QELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEE 2069
Query: 714 VTKKRKDVKKDTTDKSSKPQIK 735
+T K +D++ + K Q K
Sbjct: 2070 MTAKVRDLQTQLEELQKKYQQK 2091
>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 [Homo
sapiens]
Length = 2191
Score = 65.1 bits (157), Expect = 4e-10
Identities = 35/121 (28%), Positives = 68/121 (56%), Gaps = 6/121 (4%)
Query: 279 EEEEEEEDDEKEKEDNSSEEEEEIEPFPE-----ERENFLQQLYKFMEDRGTPINKRPVL 333
EE + + + +K +S+ E+I E ER+ ++ + FME+RG+P++ P +
Sbjct: 976 EEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAV 1035
Query: 334 GYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGF 393
G + L+LF+L+ V ++GG + W+++ +L + +SAA ++K Y +YL+ F
Sbjct: 1036 GKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAAS-SLKKQYIQYLFAF 1094
Query: 394 E 394
E
Sbjct: 1095 E 1095
Score = 31.2 bits (69), Expect = 6.3
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 5/96 (5%)
Query: 270 KEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINK 329
+E+ + ++EE+EED+E++ E S+E+ I + ++ K + + +K
Sbjct: 1673 EEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPK----QASKFDK 1728
Query: 330 RPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQV 365
P+ + NLF + R KLG SG + Q+
Sbjct: 1729 LPIKIVKKNNLFVVDR-SDKLGRVQEFNSGLLHWQL 1763
>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 [Homo
sapiens]
Length = 2178
Score = 65.1 bits (157), Expect = 4e-10
Identities = 35/121 (28%), Positives = 68/121 (56%), Gaps = 6/121 (4%)
Query: 279 EEEEEEEDDEKEKEDNSSEEEEEIEPFPE-----ERENFLQQLYKFMEDRGTPINKRPVL 333
EE + + + +K +S+ E+I E ER+ ++ + FME+RG+P++ P +
Sbjct: 963 EEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAV 1022
Query: 334 GYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGF 393
G + L+LF+L+ V ++GG + W+++ +L + +SAA ++K Y +YL+ F
Sbjct: 1023 GKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAAS-SLKKQYIQYLFAF 1081
Query: 394 E 394
E
Sbjct: 1082 E 1082
Score = 31.2 bits (69), Expect = 6.3
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 5/96 (5%)
Query: 270 KEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINK 329
+E+ + ++EE+EED+E++ E S+E+ I + ++ K + + +K
Sbjct: 1660 EEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPK----QASKFDK 1715
Query: 330 RPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQV 365
P+ + NLF + R KLG SG + Q+
Sbjct: 1716 LPIKIVKKNNLFVVDR-SDKLGRVQEFNSGLLHWQL 1750
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 63.5 bits (153), Expect = 1e-09
Identities = 151/813 (18%), Positives = 299/813 (36%), Gaps = 143/813 (17%)
Query: 451 EEKPIEDEIERKENIKPSLGSKKNLLESIPTHSD---QEKEVNIKKPEDNENLDDKDDDT 507
E + E+E++ +G+ + + IP D E E + KK DN+ K+ T
Sbjct: 775 ESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQG--HKNLKT 832
Query: 508 TRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDE 567
++ S + + + E E S K I+ D+ +PK + + +DK K++
Sbjct: 833 SQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR-LPKKQQASASTDGVDKLSGKEQ 891
Query: 568 KYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESS 627
++ + ++R++++ + H+K+ + +GL
Sbjct: 892 SFT--SLEVRKVAE--------------------TKEKSKHLKTKTCKKVQDGLSDIAEK 929
Query: 628 AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK 687
+Q DE D + K + ++ + +I E+Q SS S
Sbjct: 930 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESS-------------SD 976
Query: 688 PVSKSPER-----LRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYC 742
K PER K I+ + T E + K R K + S + GK C
Sbjct: 977 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1036
Query: 743 NTEECLKT--GSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKR 800
++ E K+ G+ G+++++ K + SSSD T+KY+ E+
Sbjct: 1037 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD------------TEKYSMKEDG- 1083
Query: 801 KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSD 860
N+SD+RL+ ++R+++ S K+ KE+ S
Sbjct: 1084 ----------------------CNSSDKRLKRIELRERRNLSS-------KRNTKEIQSG 1114
Query: 861 SDTEAA--ASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEV 918
S + A +S + ++ + + + +E+ + K ++ S + ++
Sbjct: 1115 SSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITS----SSSSDI 1170
Query: 919 NDRKAEFPSSGSNSVLNTPPTTP----ESPSSVTVTEGSRQQSS---VTVSEPLAPNQEE 971
D GS+ P T S + + G S VTV + N E
Sbjct: 1171 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE 1230
Query: 972 VR------------SIKSETDSTIEVDSVAGELQ-DLQSEGNSSPAGFDASVSSSSSNQP 1018
R ++ S+ D + + + G+ + Q+E N V+S S +
Sbjct: 1231 NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDS 1290
Query: 1019 E----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSD------ 1068
E P + + + V D + G K + + HK N++K +S D
Sbjct: 1291 EESKKPRYRHRLLRHKLTVSDGE-SGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQES 1349
Query: 1069 --SEELSAGES----ITKSQPVKSVSTGMKSHSTKSPAR-----TQSPGKCGKNGDKDPD 1117
SEE+S E T+S + +S+ K R S + N +++ +
Sbjct: 1350 GVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEE 1409
Query: 1118 LKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKR 1177
KE + + + + ++ + + +++ L++ K ++ + + RRKR
Sbjct: 1410 EKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKD-DKLRTETQNALKEEEERRKR 1468
Query: 1178 LKKKERE----SAATSSSSSSPSSSSITAAVML 1206
+ ++ERE +SP+ IT ++L
Sbjct: 1469 IAEREREREKLREVIEIEDASPTKCPITTKLVL 1501
Score = 53.1 bits (126), Expect = 2e-06
Identities = 109/527 (20%), Positives = 201/527 (38%), Gaps = 61/527 (11%)
Query: 717 KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSS 776
++KD+ K S K + TEE S G + +K+ KE E ++ S
Sbjct: 415 EKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSED 474
Query: 777 DEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 836
+ + + P + LE + + S E+ ++ +S +L N +K
Sbjct: 475 LDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE---SSSVKL-NISSK 530
Query: 837 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 896
D + I+ + K KEL+ + ++ P + +E Q +SC +
Sbjct: 531 DNR---GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD---CQEVPQDKDGYKSCGLNP 584
Query: 897 ELEKPP--PVNVDSKPIEEKTV----EVND--RKAEFPSSGSNSVLNTPPTTPESPSSVT 948
+LEK N D++ + E V E +D R ++ T P T S
Sbjct: 585 KLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 644
Query: 949 VTEGSRQQSSVTV--------SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGN 1000
T +Q+ SV V S+ N + + KS+ T++ +S + E+ + E +
Sbjct: 645 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 704
Query: 1001 --SSPAGFDASVSSSSSNQPE----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1054
S + D ++ +N K G+++ K + G K+ +S K+++
Sbjct: 705 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 764
Query: 1055 VNNKKKGKGTNSS--DSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNG 1112
++ KK+ + SS DSE +S++K ++ + + + + K G +
Sbjct: 765 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 824
Query: 1113 DKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEV---A 1169
+LK TS E + E+ QE R+ + S + V
Sbjct: 825 QGHKNLK----------------------TSQEGSSDDAERKQE-RETFSSAEGTVDKDT 861
Query: 1170 SIDRRRKRLKKKERESAATSS-SSSSPSSSSITAAVMLTLAEPSMSS 1215
+I R RL KK++ SA+T S S T+ + +AE S
Sbjct: 862 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 908
Score = 47.0 bits (110), Expect = 1e-04
Identities = 141/706 (19%), Positives = 268/706 (37%), Gaps = 93/706 (13%)
Query: 477 ESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKAD 536
+ +P D K + + L ++ D + E+ +V E++ +K
Sbjct: 568 QEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN---EVSLLLEESDLRRSPRVKTT 624
Query: 537 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMV--S 594
+ RP + N P + + N+ KEK K P K +R S NP P + S
Sbjct: 625 PLRRPTETN-PVTSNSDEECNETVKEKQKLSV--PVRKKDKRNSSDSAIDNPKPNKLPKS 681
Query: 595 KLDLTDAKNSDTAHIKSIEITSILNGL-QASESSAEDSEQEDERGAQDMDNNGKEESKID 653
K T +NSD S E+ +IL + + S SS+ D++ ++ N K + D
Sbjct: 682 KQSETVDQNSD-----SDEMLAILKEVSRMSHSSSSDTD------INEIHTNHK--TLYD 728
Query: 654 HLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVS-KSPERLRKDIEVLSEDTDYEED 712
T D K ++ SS+ +D K S KS +K + SE ++Y+
Sbjct: 729 LKTQAGKDDKGKRKRKSSTS------GSDFDTKKGKSAKSSIISKKKRQTQSESSNYDS- 781
Query: 713 EVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSS 772
E+ K+ K + K +++K +I K + +E K G + KN ++ S
Sbjct: 782 ELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE--KHSKKGMDNQGHKN-----LKTSQ 834
Query: 773 NSSSDEDEEETKAK------------MTPTKKYNGLEEKRKSLRTT-------GFYSGFS 813
SSD+ E + + + T + + L +K+++ +T G F+
Sbjct: 835 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894
Query: 814 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSD-------TEAA 866
+ +++ + L+ K +D S I ++ KK + S+ D TE
Sbjct: 895 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK 954
Query: 867 ASPPHPAPEEGVAEESLQTVAE--------EESCSPSVELEKPPPVNVD----SKPIEEK 914
P + E+ ++ ++ EE C +++ D SK I +K
Sbjct: 955 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDK 1014
Query: 915 TVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRS 974
T + D +++ + + E S G R++ + + +++ S
Sbjct: 1015 TSKKKDELSDYAEKSTGK--GDSCDSSEDKKSKNGAYG-REKKRCKLLGKSSRKRQDCSS 1071
Query: 975 IKSETDSTIEVDSVAGELQ----DLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQ 1030
+E S E + + + +L+ N S + S SS+ E E +
Sbjct: 1072 SDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED--NKK 1129
Query: 1031 KRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSS-----DSEELSAGESITKSQPVK 1085
K+ + + + K+K+ + +K+ T+SS D ++ S GE + Q +K
Sbjct: 1130 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1189
Query: 1086 SVSTGMKSHSTKSPARTQSPGKCGKN----GDKDPDLKEPSNRLPK 1127
V+ + S ++ K+ D D D +P NR+ K
Sbjct: 1190 PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1235
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 17/179 (9%)
Query: 134 PVIGKKTNRGRRSNHIPEEES-------SSSSSDEDEDDRKQIDELLGKVVCVDYISLDK 186
P GKK + + +EE+ S S S+E + R + L K+ D S ++
Sbjct: 1258 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1317
Query: 187 KKALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFT-SVPRKDVHEITSDTAPKPDAV 244
KK P E+ + + + +D F S ++V E + P+ +
Sbjct: 1318 KKTK--------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1369
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIE 303
K E+ +K + K + S + EEEEEE +E+E+E+ EEEEE E
Sbjct: 1370 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Score = 43.1 bits (100), Expect = 0.002
Identities = 122/646 (18%), Positives = 248/646 (38%), Gaps = 113/646 (17%)
Query: 95 DGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEES 154
DG EK R +C HF + + T+ E + K + + + E+ +
Sbjct: 976 DGTEKLPEREEIC-----HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1030
Query: 155 SSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILV 214
S + +D+K + G+ +KK+ +L
Sbjct: 1031 GKGDSCDSSEDKKSKNGAYGR---------EKKRC---------------------KLLG 1060
Query: 215 RSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT-ELKEDS 273
+S + + S + + + D D LK+ +E + R + + T E++ S
Sbjct: 1061 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR-----IELRERRNLSSKRNTKEIQSGS 1115
Query: 274 SSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVL 333
SSS+AEE E D++K+K+ SS+++ I E++ N L+ K + T + +
Sbjct: 1116 SSSDAEESSE--DNKKKKQRTSSKKKAVI--VKEKKRNSLRTSTKRKQADITSSSSSDIE 1171
Query: 334 GYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGF 393
++ + G D + K V ++L VL+S G+ C G
Sbjct: 1172 DDDQNSIGE--------GSSDEQKI----KPVTENL---VLSSHTGF---CQSS----GD 1209
Query: 394 EEYCRSANI----EFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIP 449
E +S + + PE + K+ E +K +E+ + E + ++R
Sbjct: 1210 EALSKSVPVTVDDDDDDNDPENRIAKKML-LEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268
Query: 450 REEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTR 509
EE P ++E + + N + S+++ H ++ + E E K +
Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRY-RHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327
Query: 510 VDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKY 569
V KV +E+ + S + E ++++ D+ P+ + KK + + + ++ +K
Sbjct: 1328 VKGRNRRKVSSEDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELE-ENQRSYKQKK 1385
Query: 570 SPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAE 629
+ K++ S ++N E K + E E
Sbjct: 1386 KRRRIKVQEDSSSENKSNSEEEEEEK--------------------------EEEEEEEE 1419
Query: 630 DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPV 689
+ E+E+E D + GK KI + ++D + E QN+ L+E + + +
Sbjct: 1420 EEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNA---LKEEEERRKRIAER-- 1472
Query: 690 SKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIK 735
+ E+LR+ IE+ ED + +T K + D +++ +P ++
Sbjct: 1473 EREREKLREVIEI--EDASPTKCPITTK---LVLDEDEETKEPLVQ 1513
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 63.5 bits (153), Expect = 1e-09
Identities = 151/813 (18%), Positives = 299/813 (36%), Gaps = 143/813 (17%)
Query: 451 EEKPIEDEIERKENIKPSLGSKKNLLESIPTHSD---QEKEVNIKKPEDNENLDDKDDDT 507
E + E+E++ +G+ + + IP D E E + KK DN+ K+ T
Sbjct: 813 ESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQG--HKNLKT 870
Query: 508 TRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDE 567
++ S + + + E E S K I+ D+ +PK + + +DK K++
Sbjct: 871 SQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR-LPKKQQASASTDGVDKLSGKEQ 929
Query: 568 KYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESS 627
++ + ++R++++ + H+K+ + +GL
Sbjct: 930 SFT--SLEVRKVAE--------------------TKEKSKHLKTKTCKKVQDGLSDIAEK 967
Query: 628 AEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISK 687
+Q DE D + K + ++ + +I E+Q SS S
Sbjct: 968 FLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESS-------------SD 1014
Query: 688 PVSKSPER-----LRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYC 742
K PER K I+ + T E + K R K + S + GK C
Sbjct: 1015 GTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC 1074
Query: 743 NTEECLKT--GSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKR 800
++ E K+ G+ G+++++ K + SSSD T+KY+ E+
Sbjct: 1075 DSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD------------TEKYSMKEDG- 1121
Query: 801 KSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSD 860
N+SD+RL+ ++R+++ S K+ KE+ S
Sbjct: 1122 ----------------------CNSSDKRLKRIELRERRNLSS-------KRNTKEIQSG 1152
Query: 861 SDTEAA--ASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEV 918
S + A +S + ++ + + + +E+ + K ++ S + ++
Sbjct: 1153 SSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITS----SSSSDI 1208
Query: 919 NDRKAEFPSSGSNSVLNTPPTTP----ESPSSVTVTEGSRQQSS---VTVSEPLAPNQEE 971
D GS+ P T S + + G S VTV + N E
Sbjct: 1209 EDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE 1268
Query: 972 VR------------SIKSETDSTIEVDSVAGELQ-DLQSEGNSSPAGFDASVSSSSSNQP 1018
R ++ S+ D + + + G+ + Q+E N V+S S +
Sbjct: 1269 NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDS 1328
Query: 1019 E----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSD------ 1068
E P + + + V D + G K + + HK N++K +S D
Sbjct: 1329 EESKKPRYRHRLLRHKLTVSDGE-SGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQES 1387
Query: 1069 --SEELSAGES----ITKSQPVKSVSTGMKSHSTKSPAR-----TQSPGKCGKNGDKDPD 1117
SEE+S E T+S + +S+ K R S + N +++ +
Sbjct: 1388 GVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEE 1447
Query: 1118 LKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKR 1177
KE + + + + ++ + + +++ L++ K ++ + + RRKR
Sbjct: 1448 EKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKD-DKLRTETQNALKEEEERRKR 1506
Query: 1178 LKKKERE----SAATSSSSSSPSSSSITAAVML 1206
+ ++ERE +SP+ IT ++L
Sbjct: 1507 IAEREREREKLREVIEIEDASPTKCPITTKLVL 1539
Score = 53.1 bits (126), Expect = 2e-06
Identities = 109/527 (20%), Positives = 201/527 (38%), Gaps = 61/527 (11%)
Query: 717 KRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSS 776
++KD+ K S K + TEE S G + +K+ KE E ++ S
Sbjct: 453 EKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSED 512
Query: 777 DEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAK 836
+ + + P + LE + + S E+ ++ +S +L N +K
Sbjct: 513 LDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVE---SSSVKL-NISSK 568
Query: 837 DRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSV 896
D + I+ + K KEL+ + ++ P + +E Q +SC +
Sbjct: 569 DNR---GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGAD---CQEVPQDKDGYKSCGLNP 622
Query: 897 ELEKPP--PVNVDSKPIEEKTV----EVND--RKAEFPSSGSNSVLNTPPTTPESPSSVT 948
+LEK N D++ + E V E +D R ++ T P T S
Sbjct: 623 KLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 682
Query: 949 VTEGSRQQSSVTV--------SEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGN 1000
T +Q+ SV V S+ N + + KS+ T++ +S + E+ + E +
Sbjct: 683 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 742
Query: 1001 --SSPAGFDASVSSSSSNQPE----PEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATV 1054
S + D ++ +N K G+++ K + G K+ +S K+++
Sbjct: 743 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSI 802
Query: 1055 VNNKKKGKGTNSS--DSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNG 1112
++ KK+ + SS DSE +S++K ++ + + + + K G +
Sbjct: 803 ISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDN 862
Query: 1113 DKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEV---A 1169
+LK TS E + E+ QE R+ + S + V
Sbjct: 863 QGHKNLK----------------------TSQEGSSDDAERKQE-RETFSSAEGTVDKDT 899
Query: 1170 SIDRRRKRLKKKERESAATSS-SSSSPSSSSITAAVMLTLAEPSMSS 1215
+I R RL KK++ SA+T S S T+ + +AE S
Sbjct: 900 TIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKS 946
Score = 47.0 bits (110), Expect = 1e-04
Identities = 141/706 (19%), Positives = 268/706 (37%), Gaps = 93/706 (13%)
Query: 477 ESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKAD 536
+ +P D K + + L ++ D + E+ +V E++ +K
Sbjct: 606 QEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVEN---EVSLLLEESDLRRSPRVKTT 662
Query: 537 KIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMV--S 594
+ RP + N P + + N+ KEK K P K +R S NP P + S
Sbjct: 663 PLRRPTETN-PVTSNSDEECNETVKEKQKLSV--PVRKKDKRNSSDSAIDNPKPNKLPKS 719
Query: 595 KLDLTDAKNSDTAHIKSIEITSILNGL-QASESSAEDSEQEDERGAQDMDNNGKEESKID 653
K T +NSD S E+ +IL + + S SS+ D++ ++ N K + D
Sbjct: 720 KQSETVDQNSD-----SDEMLAILKEVSRMSHSSSSDTD------INEIHTNHK--TLYD 766
Query: 654 HLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVS-KSPERLRKDIEVLSEDTDYEED 712
T D K ++ SS+ +D K S KS +K + SE ++Y+
Sbjct: 767 LKTQAGKDDKGKRKRKSSTS------GSDFDTKKGKSAKSSIISKKKRQTQSESSNYDS- 819
Query: 713 EVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSS 772
E+ K+ K + K +++K +I K + +E K G + KN ++ S
Sbjct: 820 ELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE--KHSKKGMDNQGHKN-----LKTSQ 872
Query: 773 NSSSDEDEEETKAK------------MTPTKKYNGLEEKRKSLRTT-------GFYSGFS 813
SSD+ E + + + T + + L +K+++ +T G F+
Sbjct: 873 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932
Query: 814 EVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSD-------TEAA 866
+ +++ + L+ K +D S I ++ KK + S+ D TE
Sbjct: 933 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEK 992
Query: 867 ASPPHPAPEEGVAEESLQTVAE--------EESCSPSVELEKPPPVNVD----SKPIEEK 914
P + E+ ++ ++ EE C +++ D SK I +K
Sbjct: 993 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDK 1052
Query: 915 TVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRS 974
T + D +++ + + E S G R++ + + +++ S
Sbjct: 1053 TSKKKDELSDYAEKSTGK--GDSCDSSEDKKSKNGAYG-REKKRCKLLGKSSRKRQDCSS 1109
Query: 975 IKSETDSTIEVDSVAGELQ----DLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQ 1030
+E S E + + + +L+ N S + S SS+ E E +
Sbjct: 1110 SDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSED--NKK 1167
Query: 1031 KRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSS-----DSEELSAGESITKSQPVK 1085
K+ + + + K+K+ + +K+ T+SS D ++ S GE + Q +K
Sbjct: 1168 KKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIK 1227
Query: 1086 SVSTGMKSHSTKSPARTQSPGKCGKN----GDKDPDLKEPSNRLPK 1127
V+ + S ++ K+ D D D +P NR+ K
Sbjct: 1228 PVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAK 1273
Score = 43.5 bits (101), Expect = 0.001
Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 17/179 (9%)
Query: 134 PVIGKKTNRGRRSNHIPEEES-------SSSSSDEDEDDRKQIDELLGKVVCVDYISLDK 186
P GKK + + +EE+ S S S+E + R + L K+ D S ++
Sbjct: 1296 PEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEE 1355
Query: 187 KKALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFT-SVPRKDVHEITSDTAPKPDAV 244
KK P E+ + + + +D F S ++V E + P+ +
Sbjct: 1356 KKTK--------PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSA 1407
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIE 303
K E+ +K + K + S + EEEEEE +E+E+E+ EEEEE E
Sbjct: 1408 KKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1466
Score = 43.1 bits (100), Expect = 0.002
Identities = 122/646 (18%), Positives = 248/646 (38%), Gaps = 113/646 (17%)
Query: 95 DGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEES 154
DG EK R +C HF + + T+ E + K + + + E+ +
Sbjct: 1014 DGTEKLPEREEIC-----HFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKST 1068
Query: 155 SSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILV 214
S + +D+K + G+ +KK+ +L
Sbjct: 1069 GKGDSCDSSEDKKSKNGAYGR---------EKKRC---------------------KLLG 1098
Query: 215 RSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKT-ELKEDS 273
+S + + S + + + D D LK+ +E + R + + T E++ S
Sbjct: 1099 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKR-----IELRERRNLSSKRNTKEIQSGS 1153
Query: 274 SSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVL 333
SSS+AEE E D++K+K+ SS+++ I E++ N L+ K + T + +
Sbjct: 1154 SSSDAEESSE--DNKKKKQRTSSKKKAVI--VKEKKRNSLRTSTKRKQADITSSSSSDIE 1209
Query: 334 GYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGF 393
++ + G D + K V ++L VL+S G+ C G
Sbjct: 1210 DDDQNSIGE--------GSSDEQKI----KPVTENL---VLSSHTGF---CQSS----GD 1247
Query: 394 EEYCRSANI----EFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIP 449
E +S + + PE + K+ E +K +E+ + E + ++R
Sbjct: 1248 EALSKSVPVTVDDDDDDNDPENRIAKKML-LEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1306
Query: 450 REEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTR 509
EE P ++E + + N + S+++ H ++ + E E K +
Sbjct: 1307 NEENPGDEEAKNQVNSESDSDSEESKKPRY-RHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365
Query: 510 VDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKY 569
V KV +E+ + S + E ++++ D+ P+ + KK + + + ++ +K
Sbjct: 1366 VKGRNRRKVSSEDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELE-ENQRSYKQKK 1423
Query: 570 SPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAE 629
+ K++ S ++N E K + E E
Sbjct: 1424 KRRRIKVQEDSSSENKSNSEEEEEEK--------------------------EEEEEEEE 1457
Query: 630 DSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPV 689
+ E+E+E D + GK KI + ++D + E QN+ L+E + + +
Sbjct: 1458 EEEEEEEDENDDSKSPGKGRKKIRKIL--KDDKLRTETQNA---LKEEEERRKRIAER-- 1510
Query: 690 SKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIK 735
+ E+LR+ IE+ ED + +T K + D +++ +P ++
Sbjct: 1511 EREREKLREVIEI--EDASPTKCPITTK---LVLDEDEETKEPLVQ 1551
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 63.2 bits (152), Expect = 2e-09
Identities = 128/689 (18%), Positives = 253/689 (36%), Gaps = 124/689 (17%)
Query: 450 REEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTR 509
R +K +++ +ER++ P++ L S +D + +K E +E+ ++
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQER------ 159
Query: 510 VDESLNIKVEAEEEKAKSGY-DEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEK 568
++E E KS ++W R A++N K DKEK+++E+
Sbjct: 160 ------YEIEETETVTKSYQKNDW-------RDAEEN-----------KKEDKEKEEEEE 195
Query: 569 YSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSA 628
PK + N MV + T +T + S+ NG +SE
Sbjct: 196 EKPKRGSIGE--------NQVEVMVE--EKTTESQEETV------VMSLKNGQISSEEPK 239
Query: 629 EDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKP 688
+ E+E E+G+ ++ ++ K E + + EE+ ++ K+
Sbjct: 240 Q--EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKI--------- 288
Query: 689 VSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECL 748
+ ER R + E + + E E ++ + +++ + +IK ++R + +
Sbjct: 289 ---ADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI 345
Query: 749 KTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGF 808
K EE+ + KE + +EEE KAK+ K+ LEEK+ +++ T
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE-KAKVEEQKRNKQLEEKKHAMQET-- 402
Query: 809 YSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAAS 868
++ +++ +++++ ++K +Q LK+ + T+ A
Sbjct: 403 -----KIKGEKV------EQKIEGKWVNEKKAQEDKLQ----TAVLKKQGEEKGTKVQA- 446
Query: 869 PPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEK-TVEVNDRKAEFPS 927
+ +E T +EE ++ +K P V S +K EV + EF +
Sbjct: 447 ------KREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMT 500
Query: 928 SGSNSVLNT--------PPTTPESPSSVTVTEGSR----------------------QQS 957
NT T E+ + V G R QQ
Sbjct: 501 HKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQE 560
Query: 958 SVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQ 1017
+ E L +EE R + E + + + +L++ + + ++ Q
Sbjct: 561 AALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQ 620
Query: 1018 PEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGES 1077
PE + +K K GSS K ++R+ NK K + + + +
Sbjct: 621 KMPE--DGLSDDKKPFKCFTPKGSSLKIEERAE----FLNKSVQKSSGVKSTHQAAIVSK 674
Query: 1078 I-TKSQPVKSVSTGMKSHSTKSPARTQSP 1105
I ++ + S G KS PA + P
Sbjct: 675 IDSRLEQYTSAIEGTKSAKPTKPAASDLP 703
Score = 58.9 bits (141), Expect = 3e-08
Identities = 108/607 (17%), Positives = 245/607 (40%), Gaps = 66/607 (10%)
Query: 224 SVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEE 283
S+P + + T++ ++ ++ E ++ T+ +++ D+ ++ +E++E
Sbjct: 131 SLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK-KEDKE 189
Query: 284 EEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKL 343
+E++E+EK S E ++E EE+ Q+ M + I+ +
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE-----------EP 238
Query: 344 FRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIE 403
+ + G D I ++ ++ A ++ ++ + E+ + A+
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERA-----EAERARLEAEERERIKA-EQDKKIADER 292
Query: 404 FQMALPEKVV--NKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDE--- 458
++ EK ++ +E E + ++ +E+ E ++ EEE+ ++ E+E
Sbjct: 293 ARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352
Query: 459 IERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKD---DDTTRVDESLN 515
E ++ IK K+ E +++E++ +++ + N+ L++K +T E +
Sbjct: 353 AEERQRIKEE--EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVE 410
Query: 516 IKVEAEEEKAKSGYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCK 575
K+E + K ++ ++ + + ++ K++ +++ KL ++K +K K+ K
Sbjct: 411 QKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKRE---KLQEDKPTFKKEEIKDEK 467
Query: 576 LRRLSKPPFQTNPSPEMVSKLDLTDAKNSD----TAHIKSIEITSILNGLQAS------- 624
+++ +P + M K T+ K+ + T +K E T G +AS
Sbjct: 468 IKKDKEPKEEVKSF--MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAE 525
Query: 625 -----ESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKV 679
E+ E RG + + K + K +L K E+ L EE +
Sbjct: 526 GAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR 585
Query: 680 HADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKR 739
+ + + E+ R L E+ + E +KR+ + +D KP
Sbjct: 586 RKQEEADRKLREEEEKRR-----LKEEIERRRAEAAEKRQKMPEDGLSDDKKP------- 633
Query: 740 RYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEK 799
C T + GS K EE+A+ ++S S+ + +K + ++Y E
Sbjct: 634 FKCFTPK----GSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKID-SRLEQYTSAIEG 688
Query: 800 RKSLRTT 806
KS + T
Sbjct: 689 TKSAKPT 695
Score = 53.1 bits (126), Expect = 2e-06
Identities = 130/662 (19%), Positives = 251/662 (37%), Gaps = 91/662 (13%)
Query: 245 LKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEI-- 302
L++A E+ EF + T + + + ++E E E+EE E +E EE E +
Sbjct: 111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK 170
Query: 303 ----EPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIES 358
+ + EN + K E+ P KR +G + +
Sbjct: 171 SYQKNDWRDAEENKKEDKEKEEEEEEKP--KRGSIGENQVEVM----------------- 211
Query: 359 GAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCK 418
V ++ + V+ S + K EE + E + +K+
Sbjct: 212 --VEEKTTESQEETVVMSLKNGQISSEEPKQ----EEEREQGSDEISHHEKMEEEDKERA 265
Query: 419 ECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLES 478
E E + + E ++ K+ +ER I EEK E ER+E ++ +
Sbjct: 266 EAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERRE------AEERERMRE 319
Query: 479 IPTHSDQEKEVNIKKPED---NENLDDKDDDTTRVDESLNIKVE---AEEEKAKSGYDEW 532
+ +E++ IK+ E E K+++ +E IK E A EE+ ++ +E
Sbjct: 320 EEKRAAEERQ-RIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378
Query: 533 IKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEM 592
KA + +K + + KH + + K+ EK ++K K ++ + QT
Sbjct: 379 EKAKVEEQKRNKQLEEKKHAMQ-ETKIKGEK-VEQKIEGKWVNEKKAQEDKLQT------ 430
Query: 593 VSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKI 652
A K ++ + LQ + + + E +DE+ +D + KEE K
Sbjct: 431 --------AVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKE--PKEEVK- 479
Query: 653 DHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEED 712
+ + + QN + + K H + S+P ++ ++ + +
Sbjct: 480 -SFMDRKKGFTEVKSQNGEFMTHKLK-HTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 537
Query: 713 EVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAK---NKESLCME 769
E+ ++R + + + +K + Q + EE K K+EE+ K +E +
Sbjct: 538 ELRRRRGETESEEFEKLKQKQ----QEAALELEELKK-----KREERRKVLEEEEQRRKQ 588
Query: 770 NSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFY-----------SGFSEVAEK 818
++ E+EE+ + K ++ EKR+ + G G S E+
Sbjct: 589 EEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEE 648
Query: 819 RIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKT--LKELFSDSDTEAAASPPHPAPEE 876
R + LN S ++ ++ + + S I + + T ++ S T+ AAS P P E
Sbjct: 649 RAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAAS-DLPVPAE 707
Query: 877 GV 878
GV
Sbjct: 708 GV 709
Score = 45.8 bits (107), Expect = 2e-04
Identities = 75/398 (18%), Positives = 162/398 (40%), Gaps = 50/398 (12%)
Query: 209 KDNILVRSFKDGKFTSVPRK--DVHEITSDTAPKPDAVLKQAFEQA------LEFHKSRT 260
++ +V S K+G+ +S K + E SD + + ++ E+A LE +
Sbjct: 220 QEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERER 279
Query: 261 IPANWKTELKEDSSSSEAEEE---EEEEDDEKEKEDNSSEEE----EEIEPFPEERENFL 313
I A ++ ++ + EAEE+ +E E E E+ + EEE EE + EE +
Sbjct: 280 IKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339
Query: 314 QQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPV 373
++ + E+ +R + K + + E V +Q
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEE----KRAAEERQRARAEEEEKAKVEEQ--------- 386
Query: 374 LNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENE 433
N + KK+ + + + + + K VN++ + + ++ +K++ E
Sbjct: 387 -----KRNKQLEEKKHAM---QETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGE 438
Query: 434 -----TEIKEIKMEEERNIIPREE---KPIEDEIERKENIKPSLGSKKNLLE------SI 479
+ K K++E++ +EE + I+ + E KE +K + KK E
Sbjct: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 498
Query: 480 PTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIV 539
TH + E +P ++D K+ + E+ E + ++ +E+ K +
Sbjct: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 558
Query: 540 RPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLR 577
+ A + ++K +++ + K+ +E+++ K + KLR
Sbjct: 559 QEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR 596
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 62.8 bits (151), Expect = 2e-09
Identities = 117/566 (20%), Positives = 220/566 (38%), Gaps = 112/566 (19%)
Query: 490 NIKKPEDNENLD-DKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNVPK 548
+I ED E+ D D+D D +DE K E ++ K +K +P K K
Sbjct: 112 DIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKD----------KTEKQEKPERKIQTK 161
Query: 549 IKHRKKIKNKLD-KEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTA 607
+ H++K K K +EK+K EK + K+ + KP +T + +K A+ S+
Sbjct: 162 VTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK----TAEKSEEK 217
Query: 608 HIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEE 667
K ++ +++ ++ A + K SK + +SK E
Sbjct: 218 TKKEVK---------------GGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHE 262
Query: 668 QNSS----SLLEENKVHADL---------------VISKPVSKSP-------ERLRKDIE 701
Q + + VH DL S+P SP E+ + + +
Sbjct: 263 QKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKK 322
Query: 702 VLSEDTDYEEDEVTKKRK-----DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKK 756
V SE E++++ KK + DV+K K+S + K+G + K KK
Sbjct: 323 VTSETKKKEKEDIKKKSEKETAIDVEKKEPGKAS--ETKQGTVKIAAQAAAKK---DEKK 377
Query: 757 EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVA 816
E+ K K+ +E ++ E+ + +P K+++ +K+ +T V+
Sbjct: 378 EDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVS 437
Query: 817 -------EKRIKLLNNSDERLQNSRA-------KDR-------KDVWSSIQGQWPKKTLK 855
+K K ++ ++ ++ KD+ + V +S++ + P+
Sbjct: 438 IKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKD 497
Query: 856 ELFSDSDTEAAASPP------HPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSK 909
E S + E PP PE + +E+ ++E+ ++ KP K
Sbjct: 498 EKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQ-DIVKPEKTVSHGK 556
Query: 910 PIE-----------EKTVEVN-DRKAEFPSSGSNSV-LNTPPTTPESPSSVTVTEGSRQQ 956
P E EKT + +KAE S+ + P TP+ S VTE +++
Sbjct: 557 PEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSE--VTESGKKK 614
Query: 957 SSVTVSEPLAPNQEEVRSIKSETDST 982
+ +SE + + +++ ++ E ST
Sbjct: 615 TE--ISEKESKEKADMKHLREEKVST 638
Score = 57.4 bits (137), Expect = 8e-08
Identities = 104/555 (18%), Positives = 213/555 (38%), Gaps = 83/555 (14%)
Query: 660 NDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRK 719
+D+IS E++ E+ I +P + E + E + + +VT K K
Sbjct: 111 SDIISSEDEEDDDGDEDTDKGE---IDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEK 167
Query: 720 DVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDED 779
+ K+ + KP+ K + +E +T + K+++KAK ++++
Sbjct: 168 EKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK-------------TAEKS 214
Query: 780 EEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRK 839
EE+TK ++ G +EK K + EV + K D+ ++K
Sbjct: 215 EEKTKKEVK-----GGKQEKVKQTA-----AKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
Query: 840 DVWSSIQGQWPKKTLKELFSDSDTEAAASP--PHPAPEEGVAEESLQTVAEEESCSPSVE 897
D ++ + + ++F D + SP P P P E + + + A EE +
Sbjct: 265 DQYAFC------RYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKK 318
Query: 898 LEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQS 957
EK V ++K E++ ++ K + ++ P S +Q
Sbjct: 319 AEK--KVTSETKKKEKEDIKKKSEK--------ETAIDVEKKEPGKASET-------KQG 361
Query: 958 SVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGF---DASVSSSS 1014
+V ++ A ++E + +T EV+ G+ Q+ + E + PA + SV S
Sbjct: 362 TVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQE-KKEKHVEPAKSPKKEHSVPSDK 420
Query: 1015 SNQPEPEHP---------EKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTN 1065
+ + E +KA G+K K + +K+K ++++ +K+ KG
Sbjct: 421 QVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKE 480
Query: 1066 SSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPS--- 1122
L E TK S K+ P Q GK K +P +K+ +
Sbjct: 481 EKVPASLKEKEPETKKDEKMS-----KAGKEVKPKPPQLQGK--KEEKPEPQIKKEAKPA 533
Query: 1123 -NRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKK 1181
+ +++K +++ E+ + +++ K ++ E + + K+ + +
Sbjct: 534 ISEKVQIHK--------QDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHR 585
Query: 1182 ERESAATSSSSSSPS 1196
ERE + + P+
Sbjct: 586 EREPPSIKTDKPKPT 600
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 62.8 bits (151), Expect = 2e-09
Identities = 128/738 (17%), Positives = 272/738 (36%), Gaps = 79/738 (10%)
Query: 409 PEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPS 468
P + Q + E ++ + +E + + + E R E+ E E ER+
Sbjct: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRE 700
Query: 469 LGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSG 528
++ L ++E+E + D + D++ + R + + EE+ +
Sbjct: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
Query: 529 YDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKD----------EKYSPKNCKLRR 578
E + + R ++ + K R++ ++ DK+K +D E +P++ R
Sbjct: 761 ERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDER 820
Query: 579 LSKPPFQT--NPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDE 636
SK ++ +PSP K + +SD + +S +D ++
Sbjct: 821 KSKKRYRNEGSPSPRQSPKRRREHSPDSD------------------AYNSGDDKNEKHR 862
Query: 637 RGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERL 696
+Q + HLT +R KEE E ++ + + + + VS S ++
Sbjct: 863 LLSQVVRPQESRSLSPSHLTEDRQGR-WKEEDRKPERKESSRRYEEQELKEKVS-SVDKQ 920
Query: 697 RKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKK 756
R+ E+L E + ++ + ++T+D++ K+ K + KK
Sbjct: 921 REQTEIL-ESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQ--------------KK 965
Query: 757 EEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVA 816
K K ++ + +E + ++ ED + K KK +E+KRK + G S+++
Sbjct: 966 PIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKK--SIEKKRKKSK------GDSDIS 1017
Query: 817 EKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEE 876
++ + + ++++ G+ L++ DT + P+
Sbjct: 1018 DEEAAQQSKKKRGPRTPPITTKEELVEMCNGK--NGILEDSQKKEDTAFSDWSDEDVPDR 1075
Query: 877 GVAEESLQT-VAEEESCSP---SVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNS 932
E+ T A +P S L PPPV + T+ A S S
Sbjct: 1076 TEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAI 1135
Query: 933 VLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGEL 992
++T T + ++ E S ++ T R K ET D+ +
Sbjct: 1136 TISTSATPTNTTNNTFANEDSHRKCHRT------------RVEKVETPHVTIEDAQHRKP 1183
Query: 993 QDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRS--- 1049
D + + + S +S P + ++ Q K GS +++ +S
Sbjct: 1184 MDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEI 1243
Query: 1050 --HKATVVNNKKKGKGTNSSDSE-ELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPG 1106
+ + ++ K+G+ + S+ S+ + S S +S P +S S S R Q
Sbjct: 1244 TGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERD 1303
Query: 1107 KCGKNGDKDPDLKEPSNR 1124
+ + +++ + ++ R
Sbjct: 1304 RYEHDRERERERRDTRQR 1321
Score = 42.7 bits (99), Expect = 0.002
Identities = 76/419 (18%), Positives = 157/419 (37%), Gaps = 48/419 (11%)
Query: 395 EYCRSANIEFQ-MALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEK 453
+Y ++E + + +++ + + E +EI +K+E E+ K+ ++ +
Sbjct: 159 DYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKS 218
Query: 454 PIEDEIERKENIKPSLGSKKN----------LLESIPTHSDQEKEVNIKKPEDNENLDDK 503
P +RK + K S SKK+ L + + ++Q K+ + P + +
Sbjct: 219 P-----KRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPED 273
Query: 504 DDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADK---NVPKIKHRKKIKNKLD 560
+ E +K + EEK + G D ++ DK P +H I ++
Sbjct: 274 IALGKKYKEKYKVK-DRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHH 332
Query: 561 KEKDKD----EKYSPKNCKLR-------RLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHI 609
+ +++SP + R R PP + + SP L K S H
Sbjct: 333 SSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR 392
Query: 610 KSIEITSILNGLQASESSAEDSEQ-EDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQ 668
+ + + S+S E+ ED RG +D + + +EE + + ++ D E
Sbjct: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP 452
Query: 669 NSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDK 728
+ + D + R +D+ E DY D TK+ +D + + +
Sbjct: 453 RDGRDRRDARDTRD--------RRELRDSRDMRDSREMRDYSRD--TKESRDPRDSRSTR 502
Query: 729 SSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKM 787
+ R R E+ +E ++ + L E+S +E E+++++
Sbjct: 503 DAHDYRDREGRDTHRKEDTY------PEESRSYGRNHLREESSRTEIRNESRNESRSEI 555
Score = 38.1 bits (87), Expect = 0.052
Identities = 65/329 (19%), Positives = 123/329 (37%), Gaps = 46/329 (13%)
Query: 624 SESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADL 683
+E S+ +E RG + KE+ KI ++ + E + + + ++ D
Sbjct: 105 TEESSSPVRKESSRGR----HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDY 160
Query: 684 VISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCN 743
V + +++++++ L ++ + +E+ K++ + K S R +
Sbjct: 161 VHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPK 220
Query: 744 TEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPT------------K 791
+ K+ S KK+ K S ++ NS +++ ++ K TP+ K
Sbjct: 221 RKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK--KGPRTPSPPPPIPEDIALGK 278
Query: 792 KY-------NGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDR-----K 839
KY + +EEK + + G F EKR K + S +S R
Sbjct: 279 KYKEKYKVKDRIEEKTRDGKDRG--RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSS 336
Query: 840 DVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELE 899
SSIQ P K S S + +PP SL + ++S
Sbjct: 337 QSGSSIQRHSPSPRRKRTPSPS-YQRTLTPPLRRSASPYPSHSLSSPQRKQS-------- 387
Query: 900 KPP----PVNVDSKPIEEKTVEVNDRKAE 924
PP P+ + E+T + +DR+ E
Sbjct: 388 -PPRHRSPMREKGRHDHERTSQSHDRRHE 415
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 62.4 bits (150), Expect = 3e-09
Identities = 121/608 (19%), Positives = 229/608 (37%), Gaps = 86/608 (14%)
Query: 492 KKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADK---IVRPADKN--- 545
KK ++ + D +DD + E L+++ + IKAD+ V+P + N
Sbjct: 43 KKKKEKKKQDFDEDDILKELEELSLEAQG------------IKADRETVAVKPTENNEEE 90
Query: 546 -VPKIKHRKKIKNKLDKEKDKD-EKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKN 603
K K +K K K D D E+ K+ K ++ +KP EM S D D N
Sbjct: 91 FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKV------EMYSGSDDDDDFN 144
Query: 604 SDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLI 663
K + SE ++S++ ER ++++G+ + D +R
Sbjct: 145 KLPKKAKG-KAQKSNKKWDGSEEDEDNSKKIKERSR--INSSGESGDESDEFLQSRKGQK 201
Query: 664 SKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKK 723
++ +E D + +K+ E D EE +K K+ ++
Sbjct: 202 KNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD---EEKAKLRKLKEKEE 258
Query: 724 DTTDKSSKPQIKRGKRRYCNTEECLK------TGSPGKKEEKAKNKESLCMENSSNSSSD 777
T K + + K +R++ EE +K TG EEKA+ ++
Sbjct: 259 LETGKKDQSKQKESQRKF--EEETVKSKVTVDTGVIPASEEKAETP-----------TAA 305
Query: 778 EDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKD 837
ED+ E K KK G +E+++ + G + ++ + L +ER + ++
Sbjct: 306 EDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER----QKRE 361
Query: 838 RKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEES---CSP 894
++ ++ K+ +E E E E L T ++ E+
Sbjct: 362 EEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEA 421
Query: 895 SVELEKPPPVNVDSKP-IEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGS 953
+++L + V V SK + +K D+K + P+ S V+E
Sbjct: 422 TLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK--------------KIPQQLESKEVSESM 467
Query: 954 RQQSSVTVSEPLAPNQEEVRS-IKSETDSTIEV------DSVAGELQDLQSEGNSSPAGF 1006
++V V E P +EE ++ E + E +++A + + + EGN
Sbjct: 468 ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNK----V 523
Query: 1007 DASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNS 1066
V + + E E E+ + ++ +G S+ + K V + K GK +
Sbjct: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEK--VSDEKDSGKTLDK 581
Query: 1067 SDSEELSA 1074
S+E+S+
Sbjct: 582 KPSKEMSS 589
Score = 46.2 bits (108), Expect = 2e-04
Identities = 112/577 (19%), Positives = 208/577 (36%), Gaps = 92/577 (15%)
Query: 403 EFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERK 462
E Q + +K K+ ++ + +K EE E + IK + E + E E+ +
Sbjct: 36 EPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKD 95
Query: 463 ENIKPSLGSKK----NLLESIPTHSDQEKEVNIKKPEDNENLDDKDD------------- 505
+ K G K+ N E + + K+ K E DD DD
Sbjct: 96 KKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQ 155
Query: 506 ------DTTRVDESLNIKVEAEEEKAKSGY-----DEWIKADKIVRPADKNVP------- 547
D + DE + K++ SG DE++++ K + KN P
Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG 215
Query: 548 ------KIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLS-KPPFQTNPSPEMVSKLDLTD 600
K + + K +K++ + +K + KLR+L K +T + K
Sbjct: 216 NEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQK---ES 272
Query: 601 AKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRN 660
+ + +KS ++T + ASE AE ++ DN G ++ K + +
Sbjct: 273 QRKFEEETVKS-KVTVDTGVIPASEEKAETPTAAED------DNEGDKKKK-----DKKK 320
Query: 661 DLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKD 720
KEE+ +E K K + ++ +L+++ E EE+E K+ ++
Sbjct: 321 KKGEKEEKE-----KEKKKGPSKATVKAMQEALAKLKEE----EERQKREEEERIKRLEE 371
Query: 721 VKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDE 780
++ ++ Q KR +++ E + GK K++ + E + +
Sbjct: 372 LEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV 431
Query: 781 EETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFS---------EVAEKRIKLLNNSDERLQ 831
E P K+ ++KRK + S EV E+ + + ++
Sbjct: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVE 491
Query: 832 NSRAKDRKDV----WSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVA 887
+D +D W ++ ++T K + E +P EE EE ++
Sbjct: 492 PEEEEDTEDAGLDDWEAMASD--EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE 549
Query: 888 EEESCSPS-----------VELEKPPPVNVDSKPIEE 913
EEE S V EK +D KP +E
Sbjct: 550 EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKE 586
Score = 44.3 bits (103), Expect = 7e-04
Identities = 56/296 (18%), Positives = 108/296 (36%), Gaps = 24/296 (8%)
Query: 427 KVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQE 486
K K E E + KE K + + ++ + E +E K + LE + +E
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEE 379
Query: 487 KEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGYDEWIKADKIVRPADKNV 546
+ + +K E + + + + + + L K + E + ++A + P+ ++
Sbjct: 380 ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSL 439
Query: 547 PKI------KHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSP-EMVSKLDLT 599
PK K RKKI +L+ ++ + ++ P + P P E + D
Sbjct: 440 PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499
Query: 600 DAKNSDTAHIKSIEITSILNGLQA-----------------SESSAEDSEQEDERGAQDM 642
DA D + S E T + G + E E E+E+E G +
Sbjct: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG 559
Query: 643 DNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRK 698
+E+ K+ ++ L K + SS E + + K+ R+ K
Sbjct: 560 SEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615
Score = 42.4 bits (98), Expect = 0.003
Identities = 25/64 (39%), Positives = 35/64 (54%), Gaps = 6/64 (9%)
Query: 268 ELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPI 327
E+KE+ E EEEEEEED+E E+E+ E E E EE E + +D G +
Sbjct: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEG-DEEDEKVSDE-----KDSGKTL 579
Query: 328 NKRP 331
+K+P
Sbjct: 580 DKKP 583
Score = 36.2 bits (82), Expect = 0.20
Identities = 16/41 (39%), Positives = 25/41 (60%)
Query: 261 IPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEE 301
+ N + E +E+ E EE EEEE++E E E + +EE+E
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
Score = 32.3 bits (72), Expect = 2.8
Identities = 18/50 (36%), Positives = 27/50 (54%), Gaps = 5/50 (10%)
Query: 262 PANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEEREN 311
P + E +E+ E+EEEEEEE E SE +EE E +E+++
Sbjct: 531 PEEEEEEEEEEEEDEESEEEEEEEG-----ESEGSEGDEEDEKVSDEKDS 575
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.124 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,564,299
Number of Sequences: 37866
Number of extensions: 2680303
Number of successful extensions: 43913
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 550
Number of HSP's successfully gapped in prelim test: 1115
Number of HSP's that attempted gapping in prelim test: 18958
Number of HSP's gapped (non-prelim): 17257
length of query: 1226
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1112
effective length of database: 13,930,794
effective search space: 15491042928
effective search space used: 15491042928
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.