Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 22035602
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035602 mitogen-activated protein kinase kinase kinase
kinase 4 isoform 1 [Homo sapiens]
(1166 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 2338 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 2279 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1978 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1546 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1545 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1540 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1539 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1484 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1484 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1459 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1459 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1413 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1410 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1410 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1287 0.0
gi|118600963 Nik related kinase [Homo sapiens] 402 e-112
gi|145275208 myosin IIIA [Homo sapiens] 306 1e-82
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 8e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 8e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 269 1e-71
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 267 4e-71
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 259 8e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 256 7e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 256 7e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 252 1e-66
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 248 2e-65
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 243 1e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 243 1e-63
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 241 2e-63
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 239 1e-62
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 2338 bits (6060), Expect = 0.0
Identities = 1166/1166 (100%), Positives = 1166/1166 (100%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPV 540
VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPV
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPV 540
Query: 541 RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS 600
RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS
Sbjct: 541 RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS 600
Query: 601 NSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVD 660
NSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVD
Sbjct: 601 NSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVD 660
Query: 661 LTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASS 720
LTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASS
Sbjct: 661 LTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASS 720
Query: 721 LNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID 780
LNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID
Sbjct: 721 LNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID 780
Query: 781 PRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 840
PRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY
Sbjct: 781 PRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 840
Query: 841 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 900
KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT
Sbjct: 841 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 900
Query: 901 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 960
ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL
Sbjct: 901 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 960
Query: 961 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1020
KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS
Sbjct: 961 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1020
Query: 1021 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1080
GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD
Sbjct: 1021 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1080
Query: 1081 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1140
VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1081 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1140
Query: 1141 FFASVRSGGSSQVYFMTLGRTSLLSW 1166
FFASVRSGGSSQVYFMTLGRTSLLSW
Sbjct: 1141 FFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 2279 bits (5905), Expect = 0.0
Identities = 1155/1220 (94%), Positives = 1156/1220 (94%), Gaps = 62/1220 (5%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRARE--- 537
VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRARE
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED 540
Query: 538 ------------------------VPVRTTS---------------------------RS 546
VP R+ S RS
Sbjct: 541 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS 600
Query: 547 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 606
PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
Sbjct: 601 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 660
Query: 607 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 666
GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
Sbjct: 661 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 720
Query: 667 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 726
ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
Sbjct: 721 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 780
Query: 727 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 786
ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
Sbjct: 781 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 840
Query: 787 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 846
SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
Sbjct: 841 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 900
Query: 847 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 906
EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
Sbjct: 901 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 960
Query: 907 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 966
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
Sbjct: 961 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1020
Query: 967 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1026
YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
Sbjct: 1021 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1080
Query: 1027 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG 1086
YLPTH IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
Sbjct: 1081 YLPTH--------IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG 1132
Query: 1087 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1146
EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1133 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1192
Query: 1147 SGGSSQVYFMTLGRTSLLSW 1166
SGGSSQVYFMTLGRTSLLSW
Sbjct: 1193 SGGSSQVYFMTLGRTSLLSW 1212
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1978 bits (5124), Expect = 0.0
Identities = 1049/1330 (78%), Positives = 1083/1330 (81%), Gaps = 174/1330 (13%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEA------LRRQQL---------------------------LQEQQLREQE-- 385
QENKERSEA L+ QQL L+EQQ RE+E
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 386 ---------------------------EYKRQLLAERQKRIEQQKEQ-RRRLEEQQR--- 414
E +R+ E ++R+E+++E RR+LEE+QR
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 415 ------------------REREARRQQEREQRRREQ------------------------ 432
RE E RQ ER QR+ +Q
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 433 --------------EEKRRLEELERRRKEEEERRRAEEEKRRVEREQE------------ 466
E K E +R R+ E+ R+ + +Q
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 467 -------------YIRRQLEEEQR--HLEVLQQQLLQEQAMLLHDHRRPHPQ------HS 505
++R E + + HL L+ + H P P+ S
Sbjct: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNV--SPVSRSHSFSDPSPKFAHHHLRS 658
Query: 506 QQPPPPQQ-----ERSKPSFHAPEPK----AHYEPADRAREVPVRTTSRSPVLSRRDSPL 556
Q P PP + + S AP+P + + + VPVRTTSRSPVLSRRDSPL
Sbjct: 659 QDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPL 718
Query: 557 QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGS 616
QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGS
Sbjct: 719 QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGS 778
Query: 617 GERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRP 676
GERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRP
Sbjct: 779 GERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRP 838
Query: 677 PHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIV 736
PHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIV
Sbjct: 839 PHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIV 898
Query: 737 HDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTS 796
HDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTS
Sbjct: 899 HDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTS 958
Query: 797 VVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGV 856
VVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGV
Sbjct: 959 VVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGV 1018
Query: 857 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 916
NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL
Sbjct: 1019 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 1078
Query: 917 RNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHK 976
RNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHK
Sbjct: 1079 RNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHK 1138
Query: 977 FMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNP 1036
FMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTH
Sbjct: 1139 FMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTH----- 1193
Query: 1037 HSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1096
IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR
Sbjct: 1194 ---IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1250
Query: 1097 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1156
SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM
Sbjct: 1251 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1310
Query: 1157 TLGRTSLLSW 1166
TLGRTSLLSW
Sbjct: 1311 TLGRTSLLSW 1320
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1546 bits (4003), Expect = 0.0
Identities = 838/1287 (65%), Positives = 951/1287 (73%), Gaps = 140/1287 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQEQAM----LLHDHRRPHPQHS---------------------------QQPP 509
LQ Q +++ + L H P +QP
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
Query: 510 PP-----------------QQERSKPSFHAPEPKAHYEPADRAR----------EVPVRT 542
++ S P+ P E DR+ +VP RT
Sbjct: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRT 592
Query: 543 TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNS 602
TS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 593 TSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
Query: 603 GSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 658
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 653 SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA-- 710
Query: 659 VDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDT 715
DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + +
Sbjct: 711 -DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIP 769
Query: 716 RAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASS 764
R + + E +V + H S + + S+EGTL++R+T S S+
Sbjct: 770 RLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSN 829
Query: 765 TLQKH-----------------------------------------KSSSSFTPFIDPRL 783
H + +SFTPF+DPR+
Sbjct: 830 GFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRV 889
Query: 784 LQISPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRK 839
Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRK
Sbjct: 890 YQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRK 949
Query: 840 YKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLV 899
YKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLV
Sbjct: 950 YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV 1009
Query: 900 TISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIA 959
TISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIA
Sbjct: 1010 TISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIA 1069
Query: 960 LKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVD 1019
LK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVD
Sbjct: 1070 LKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVD 1129
Query: 1020 SGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITK 1079
SG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITK
Sbjct: 1130 SGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITK 1181
Query: 1080 DVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDK 1139
DVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDK
Sbjct: 1182 DVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDK 1241
Query: 1140 VFFASVRSGGSSQVYFMTLGRTSLLSW 1166
VFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1242 VFFASVRSGGSSQVFFMTLNRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1545 bits (4001), Expect = 0.0
Identities = 838/1292 (64%), Positives = 952/1292 (73%), Gaps = 142/1292 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQEQAM----LLHDHRRPHPQHS---------------------------QQPP 509
LQ Q +++ + L H P +QP
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
Query: 510 PP-----------------QQERSKPSFHAPEPKAHYEPADRAR----------EVPVRT 542
++ S P+ P E DR+ +VP RT
Sbjct: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRT 592
Query: 543 TSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNS 602
TS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 593 TSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTP 652
Query: 603 GSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG- 657
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 653 SSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASY 712
Query: 658 ----EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTS 710
+ DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + +
Sbjct: 713 KKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVA 772
Query: 711 GPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT-------- 759
+ R + + E +V + H S + + S+EGTL++R+T
Sbjct: 773 VSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSG 832
Query: 760 QSASSTLQKH-----------------------------------------KSSSSFTPF 778
S S+ H + +SFTPF
Sbjct: 833 HSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPF 892
Query: 779 IDPRLLQISPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDT 834
+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDT
Sbjct: 893 VDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDT 952
Query: 835 PEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEG 894
PEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEG
Sbjct: 953 PEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEG 1012
Query: 895 LNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIK 954
LNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIK
Sbjct: 1013 LNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIK 1072
Query: 955 FLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFH 1014
FLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH
Sbjct: 1073 FLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFH 1132
Query: 1015 AVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTY 1074
+DVDSG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTY
Sbjct: 1133 VIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1184
Query: 1075 GRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1134
GRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1185 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1244
Query: 1135 ERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
ERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1245 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1540 bits (3986), Expect = 0.0
Identities = 841/1312 (64%), Positives = 955/1312 (72%), Gaps = 161/1312 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEE-RRRAEEEKRRVE----------------- 462
+QQEREQRR +E+ RR EE R E+E RR+ EEE+R++E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 463 -------REQEYIRRQLEEEQRHLEVLQQQLLQEQAM----LLHDHRRPHPQHS------ 505
R+ E ++RQL++E+ +L LQ Q +++ + L H P
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 506 ---------------------QQPPPP-----------------QQERSKPSFHAPEPKA 527
+QP ++ S P+ P
Sbjct: 537 IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPT 596
Query: 528 HYEPADRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 577
E DR+ +VP RTTS SP L+R++SP GS Q S+ +
Sbjct: 597 RIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDL 656
Query: 578 RLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPS 633
R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGSP
Sbjct: 657 RRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPV 716
Query: 634 QRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEES 690
E A KPE+ +++ RP +PA DLTALAKELR + E RP KVTDYSSSSEES
Sbjct: 717 LPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEES 773
Query: 691 GTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMT 747
+++EE++D E E D + + + R + + E +V + H S + +
Sbjct: 774 ESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGS 833
Query: 748 PSKEGTLIVRQT--------QSASSTLQKH------------------------------ 769
S+EGTL++R+T S S+ H
Sbjct: 834 ISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQE 893
Query: 770 -----------KSSSSFTPFIDPRLLQISPS----SGTTVTSVVGFSCDGMRPEAIRQDP 814
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R E + +
Sbjct: 894 MDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNE 953
Query: 815 TRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQ 874
RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQ
Sbjct: 954 ARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQ 1013
Query: 875 GKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWT 934
GKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW
Sbjct: 1014 GKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWI 1073
Query: 935 TVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVD 994
TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVD
Sbjct: 1074 TVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVD 1133
Query: 995 LTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPN 1054
LTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+H++ N I PHAI+ILP
Sbjct: 1134 LTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPK 1185
Query: 1055 TDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE 1114
TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVE
Sbjct: 1186 TDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVE 1245
Query: 1115 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1246 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1539 bits (3984), Expect = 0.0
Identities = 841/1317 (63%), Positives = 956/1317 (72%), Gaps = 163/1317 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEE-RRRAEEEKRRVE----------------- 462
+QQEREQRR +E+ RR EE R E+E RR+ EEE+R++E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 463 -------REQEYIRRQLEEEQRHLEVLQQQLLQEQAM----LLHDHRRPHPQHS------ 505
R+ E ++RQL++E+ +L LQ Q +++ + L H P
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 506 ---------------------QQPPPP-----------------QQERSKPSFHAPEPKA 527
+QP ++ S P+ P
Sbjct: 537 IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPT 596
Query: 528 HYEPADRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 577
E DR+ +VP RTTS SP L+R++SP GS Q S+ +
Sbjct: 597 RIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDL 656
Query: 578 RLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPS 633
R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGSP
Sbjct: 657 RRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPV 716
Query: 634 QRLENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDYSS 685
E A KPE+ +++ RP +PA + DLTALAKELR + E RP KVTDYSS
Sbjct: 717 LPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSS 776
Query: 686 SSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP- 744
SSEES +++EE++D E E D + + + R + + E +V + H S
Sbjct: 777 SSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHAD 836
Query: 745 --AMTPSKEGTLIVRQT--------QSASSTLQKH------------------------- 769
+ + S+EGTL++R+T S S+ H
Sbjct: 837 SFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVS 896
Query: 770 ----------------KSSSSFTPFIDPRLLQISPS----SGTTVTSVVGFSCDGMRPEA 809
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R E
Sbjct: 897 THSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQ 956
Query: 810 IRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLL 869
+ + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLL
Sbjct: 957 AKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLL 1016
Query: 870 DRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEK 929
DRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEK
Sbjct: 1017 DRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEK 1076
Query: 930 KQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHK 989
KQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HK
Sbjct: 1077 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK 1136
Query: 990 PLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAI 1049
PLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+H++ N I PHAI
Sbjct: 1137 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAI 1188
Query: 1050 IILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIE 1109
+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIE
Sbjct: 1189 VILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIE 1248
Query: 1110 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1249 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1484 bits (3843), Expect = 0.0
Identities = 832/1345 (61%), Positives = 942/1345 (70%), Gaps = 201/1345 (14%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ------- 413
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQ
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 414 ---------------RREREARR----------------QQEREQRRREQE--------- 433
RRE E RR Q ER QR+ +QE
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQH 476
Query: 434 ---EKRRLE--------------ELERRRKEEEERRRAEEEK---------RRVE----- 462
E+R +E E KE EER R + R+
Sbjct: 477 QRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLP 536
Query: 463 -REQEY------------IRRQLEEEQRHLEVLQQQ---LLQEQAMLLHDHRRPHP---- 502
R + + + R ++ + HL ++ Q L Q++ H +P
Sbjct: 537 PRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSV----HEQPTKGLSG 592
Query: 503 --------QHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAR----------EVPVRTTS 544
H + P ++ S P+ P E DR+ +VP RTTS
Sbjct: 593 FQEALNVTSHRVEMP---RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 649
Query: 545 RSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGS 604
SP L+R++SP GS Q S+ + R +E + R SGSSS SS S
Sbjct: 650 ISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSS 709
Query: 605 QP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVD 660
QP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA D
Sbjct: 710 QPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---D 766
Query: 661 LTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRA 717
LTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R
Sbjct: 767 LTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRL 826
Query: 718 ASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASS---------- 764
+ + E +V + H S + + S+EGTL++R+T
Sbjct: 827 IPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGF 886
Query: 765 ---------TLQKHK------------------------------SSSSFTPFIDPRLLQ 785
Q H + +SFTPF+DPR+ Q
Sbjct: 887 AGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQ 946
Query: 786 ISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYK 841
SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYK
Sbjct: 947 TSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYK 1006
Query: 842 KRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTI 901
KRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTI
Sbjct: 1007 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTI 1066
Query: 902 SGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALK 961
SGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK
Sbjct: 1067 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALK 1126
Query: 962 SSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSG 1021
++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG
Sbjct: 1127 NAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSG 1186
Query: 1022 SVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1081
+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDV
Sbjct: 1187 NSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDV 1238
Query: 1082 VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1141
VLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
Sbjct: 1239 VLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1298
Query: 1142 FASVRSGGSSQVYFMTLGRTSLLSW 1166
FASVRSGGSSQV+FMTL R S+++W
Sbjct: 1299 FASVRSGGSSQVFFMTLNRNSMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1484 bits (3841), Expect = 0.0
Identities = 832/1350 (61%), Positives = 943/1350 (69%), Gaps = 203/1350 (15%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ------- 413
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQ
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 414 ---------------RREREARR----------------QQEREQRRREQE--------- 433
RRE E RR Q ER QR+ +QE
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQH 476
Query: 434 ---EKRRLE--------------ELERRRKEEEERRRAEEEK---------RRVE----- 462
E+R +E E KE EER R + R+
Sbjct: 477 QRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLP 536
Query: 463 -REQEY------------IRRQLEEEQRHLEVLQQQ---LLQEQAMLLHDHRRPHP---- 502
R + + + R ++ + HL ++ Q L Q++ H +P
Sbjct: 537 PRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSV----HEQPTKGLSG 592
Query: 503 --------QHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAR----------EVPVRTTS 544
H + P ++ S P+ P E DR+ +VP RTTS
Sbjct: 593 FQEALNVTSHRVEMP---RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTS 649
Query: 545 RSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGS 604
SP L+R++SP GS Q S+ + R +E + R SGSSS SS S
Sbjct: 650 ISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSS 709
Query: 605 QP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG--- 657
QP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 710 QPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKK 769
Query: 658 --EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGP 712
+ DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + +
Sbjct: 770 AIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVS 829
Query: 713 EDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASS----- 764
+ R + + E +V + H S + + S+EGTL++R+T
Sbjct: 830 DIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHS 889
Query: 765 --------------TLQKHK------------------------------SSSSFTPFID 780
Q H + +SFTPF+D
Sbjct: 890 DSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVD 949
Query: 781 PRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPE 836
PR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPE
Sbjct: 950 PRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPE 1009
Query: 837 IRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLN 896
IRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLN
Sbjct: 1010 IRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLN 1069
Query: 897 VLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFL 956
VLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFL
Sbjct: 1070 VLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFL 1129
Query: 957 VIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAV 1016
VIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +
Sbjct: 1130 VIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVI 1189
Query: 1017 DVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGR 1076
DVDSG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTYGR
Sbjct: 1190 DVDSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGR 1241
Query: 1077 ITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER 1136
ITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER
Sbjct: 1242 ITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER 1301
Query: 1137 NDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
NDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1302 NDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1459 bits (3778), Expect = 0.0
Identities = 825/1374 (60%), Positives = 942/1374 (68%), Gaps = 230/1374 (16%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRI--------------------- 399
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRI
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 400 -EQQKEQRR------------------------RLEEQQR-------------------- 414
+Q++EQRR +LEE+QR
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 415 -REREARRQQEREQRRREQE------------EKRRLE--------------ELERRRKE 447
++ E +RQ ER QR+ +QE E+R +E E KE
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 448 EEERRRAEEEK---------RRVE------REQEY------------IRRQLEEEQRHLE 480
EER R + R+ R + + + R ++ + HL
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLV 596
Query: 481 VLQQQ---LLQEQAMLLHDHRRPHP------------QHSQQPPPPQQERSKPSFHAPEP 525
++ Q L Q++ H +P H + P ++ S P+ P
Sbjct: 597 AVKSQGPALTASQSV----HEQPTKGLSGFQEALNVTSHRVEMP---RQNSDPTSENPPL 649
Query: 526 KAHYEPADRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSI 575
E DR+ +VP RTTS SP L+R++SP GS Q S+
Sbjct: 650 PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNP 709
Query: 576 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGS 631
+ R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGS
Sbjct: 710 DLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGS 769
Query: 632 PSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSE 688
P E A KPE+ +++ RP +PA DLTALAKELR + E RP KVTDYSSSSE
Sbjct: 770 PVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSE 826
Query: 689 ESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---A 745
ES +++EE++D E E D + + + R + + E +V + H S +
Sbjct: 827 ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFS 886
Query: 746 MTPSKEGTLIVRQTQSASS-------------------TLQKHK---------------- 770
+ S+EGTL++R+T Q H
Sbjct: 887 GSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHS 946
Query: 771 --------------SSSSFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQ 812
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R E +
Sbjct: 947 QEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKL 1006
Query: 813 DPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRS 872
+ RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRS
Sbjct: 1007 NEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS 1066
Query: 873 GQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQG 932
GQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQG
Sbjct: 1067 GQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQG 1126
Query: 933 WTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLL 992
W TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLL
Sbjct: 1127 WITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLL 1186
Query: 993 VDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIIL 1052
VDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+H++ N I PHAI+IL
Sbjct: 1187 VDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVIL 1238
Query: 1053 PNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRS 1112
P TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRS
Sbjct: 1239 PKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRS 1298
Query: 1113 VETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
VETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1299 VETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1459 bits (3776), Expect = 0.0
Identities = 825/1379 (59%), Positives = 943/1379 (68%), Gaps = 232/1379 (16%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRI--------------------- 399
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRI
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 400 -EQQKEQRR------------------------RLEEQQR-------------------- 414
+Q++EQRR +LEE+QR
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 415 -REREARRQQEREQRRREQE------------EKRRLE--------------ELERRRKE 447
++ E +RQ ER QR+ +QE E+R +E E KE
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 448 EEERRRAEEEK---------RRVE------REQEY------------IRRQLEEEQRHLE 480
EER R + R+ R + + + R ++ + HL
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLV 596
Query: 481 VLQQQ---LLQEQAMLLHDHRRPHP------------QHSQQPPPPQQERSKPSFHAPEP 525
++ Q L Q++ H +P H + P ++ S P+ P
Sbjct: 597 AVKSQGPALTASQSV----HEQPTKGLSGFQEALNVTSHRVEMP---RQNSDPTSENPPL 649
Query: 526 KAHYEPADRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSI 575
E DR+ +VP RTTS SP L+R++SP GS Q S+
Sbjct: 650 PTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNP 709
Query: 576 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGS 631
+ R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGS
Sbjct: 710 DLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGS 769
Query: 632 PSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDY 683
P E A KPE+ +++ RP +PA + DLTALAKELR + E RP KVTDY
Sbjct: 770 PVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDY 829
Query: 684 SSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESE 743
SSSSEES +++EE++D E E D + + + R + + E +V + H S
Sbjct: 830 SSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSH 889
Query: 744 P---AMTPSKEGTLIVRQTQSASS-------------------TLQKHK----------- 770
+ + S+EGTL++R+T Q H
Sbjct: 890 ADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGR 949
Query: 771 -------------------SSSSFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRP 807
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R
Sbjct: 950 VSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQ 1009
Query: 808 EAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLM 867
E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLM
Sbjct: 1010 EQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM 1069
Query: 868 LLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEV 927
LLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEV
Sbjct: 1070 LLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEV 1129
Query: 928 EKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELV 987
EKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L
Sbjct: 1130 EKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQ 1189
Query: 988 HKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPH 1047
HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+H++ N I PH
Sbjct: 1190 HKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPH 1241
Query: 1048 AIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKA 1107
AI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKA
Sbjct: 1242 AIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKA 1301
Query: 1108 IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1302 IEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1413 bits (3658), Expect = 0.0
Identities = 796/1325 (60%), Positives = 910/1325 (68%), Gaps = 189/1325 (14%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 -----------------------RQQEREQ--RRREQEEKRR--------------LEEL 441
RQ EREQ +R++ EE+R+ L+ L
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 442 ERRRKEEEERRRAEEEKRRVEREQEYI-------------RRQLEEEQRHLEVLQQQLLQ 488
++++++++ +++ +++ +R+ Y R++EE R + Q L
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTR-MNKQQNSPLA 538
Query: 489 EQAMLLHDHRRPHPQHSQQPP------PPQQERSKPS----------------FHAPEPK 526
+ P PQ S PP PP Q +P + AP P+
Sbjct: 539 KSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR 598
Query: 527 ----------------AHYEPADRAREVPVRTTS-RSPVLSRRDSPL-QGSGQQNSQAGQ 568
A ++P D A P T S R V+ + P +G G +
Sbjct: 599 SQSLQDQPTRNLAAFPASHDP-DPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAW 657
Query: 569 RNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPG----------------- 611
+ P++ +R + + + GS + + S+P
Sbjct: 658 VRPDNEAPPKVP-QRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPA 716
Query: 612 -----SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 666
Q+GS ER RV SSK + SP N K P+D + RP +PA V L K
Sbjct: 717 SHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPADFV----LLK 769
Query: 667 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 726
E E RPP K DYSSSSEE E +D E+EG G DT S +G
Sbjct: 770 ERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRDTPGGRS----DG 821
Query: 727 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA------------------------ 762
+T+SV TM+VHD E P GT++V++T
Sbjct: 822 DTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHS 881
Query: 763 --------------------SSTLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFS 801
S L K SSFT F+D + Q S + +T++VG
Sbjct: 882 PTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG- 940
Query: 802 CDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVG 861
+G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEILCAALWGVNLLVG
Sbjct: 941 -EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVG 998
Query: 862 TESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKIL 921
TE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKIL
Sbjct: 999 TENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKIL 1058
Query: 922 HNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK 981
HNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK
Sbjct: 1059 HNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK 1118
Query: 982 SFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQ 1041
SF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P H IQ
Sbjct: 1119 SFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVH--------IQ 1170
Query: 1042 CSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTM 1101
I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQ M
Sbjct: 1171 SQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIM 1230
Query: 1102 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT 1161
GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTL R
Sbjct: 1231 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRN 1290
Query: 1162 SLLSW 1166
+++W
Sbjct: 1291 CIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1410 bits (3650), Expect = 0.0
Identities = 795/1329 (59%), Positives = 909/1329 (68%), Gaps = 189/1329 (14%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 -----------------------RQQEREQ--RRREQEEKRR--------------LEEL 441
RQ EREQ +R++ EE+R+ L+ L
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 442 ERRRKEEEERRRAEEEKRRVEREQEYI-------------RRQLEEEQRHLEVLQQQLLQ 488
++++++++ +++ +++ +R+ Y R++EE R + Q L
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTR-MNKQQNSPLA 538
Query: 489 EQAMLLHDHRRPHPQHSQQPP------PPQQERSKPS----------------FHAPEPK 526
+ P PQ S PP PP Q +P + AP P+
Sbjct: 539 KSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR 598
Query: 527 ----------------AHYEPADRAREVPVRTTS-RSPVLSRRDSPL-QGSGQQNSQAGQ 568
A ++P D A P T S R V+ + P +G G +
Sbjct: 599 SQSLQDQPTRNLAAFPASHDP-DPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAW 657
Query: 569 RNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPG----------------- 611
+ P++ +R + + + GS + + S+P
Sbjct: 658 VRPDNEAPPKVP-QRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPA 716
Query: 612 -----SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTA--- 663
Q+GS ER RV SSK + SP N K P+D + RP +PA
Sbjct: 717 SHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPASYKRAIGEDF 773
Query: 664 -LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLN 722
L KE E RPP K DYSSSSEE E +D E+EG G DT S
Sbjct: 774 VLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRDTPGGRS-- 827
Query: 723 LSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA-------------------- 762
+G+T+SV TM+VHD E P GT++V++T
Sbjct: 828 --DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQ 885
Query: 763 ------------------------SSTLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSV 797
S L K SSFT F+D + Q S + +T++
Sbjct: 886 PSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITAL 945
Query: 798 VGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVN 857
VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEILCAALWGVN
Sbjct: 946 VGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVN 1002
Query: 858 LLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLR 917
LLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLR
Sbjct: 1003 LLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLR 1062
Query: 918 NKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKF 977
NKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKF
Sbjct: 1063 NKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKF 1122
Query: 978 MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPH 1037
MAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P H
Sbjct: 1123 MAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVH------ 1176
Query: 1038 SMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRS 1097
IQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1177 --IQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1234
Query: 1098 NQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1157
NQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT
Sbjct: 1235 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1294
Query: 1158 LGRTSLLSW 1166
L R +++W
Sbjct: 1295 LNRNCIMNW 1303
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1410 bits (3649), Expect = 0.0
Identities = 803/1346 (59%), Positives = 914/1346 (67%), Gaps = 214/1346 (15%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 -----------------------RQQEREQ----------------RRREQEEKRRLEEL 441
RQ EREQ +R+ Q+E L+ L
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 442 ERRRKEEEERR------------------------------RAEEEKRRVEREQEY---- 467
++++++++ ++ R EE+ R+ ++Q
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
Query: 468 ----------------------------IRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRR 499
++R +E ++ + LQ Q + A H
Sbjct: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLQDQPTRNLAAFPASHDP 599
Query: 500 ----PHPQHS--------QQPPPPQQERSKPSFHAPEPKAHYEPADRAR-EVPVRTTSRS 546
P P + +Q P E PS P P A P + A +VP RT+S +
Sbjct: 600 DPAIPAPTATPSARGAVIRQNSDPTSEGPGPS---PNPPAWVRPDNEAPPKVPQRTSSIA 656
Query: 547 PVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSG 603
L+ + G + +QA + R ++S L R E+ P+P + G N+
Sbjct: 657 TALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNAS 712
Query: 604 SQPG---SHPG---------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPED 645
S P S PG Q+GS ER RV SSK + SP N K P+D
Sbjct: 713 SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDD 771
Query: 646 KKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGA 705
+ RP +PA V L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 772 HRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGE 821
Query: 706 DESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--- 762
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 822 GGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN 877
Query: 763 -----------------------------------------SSTLQKHKSSSSFTPFIDP 781
S L K SSFT F+D
Sbjct: 878 LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDL 937
Query: 782 RLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 840
+ Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKY
Sbjct: 938 GIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKY 994
Query: 841 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 900
KKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+T
Sbjct: 995 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLIT 1054
Query: 901 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 960
ISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIAL
Sbjct: 1055 ISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIAL 1114
Query: 961 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1020
KSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDS
Sbjct: 1115 KSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDS 1174
Query: 1021 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1080
G+ YDIY+P H IQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KD
Sbjct: 1175 GNSYDIYIPVH--------IQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKD 1226
Query: 1081 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1140
VVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1227 VVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1286
Query: 1141 FFASVRSGGSSQVYFMTLGRTSLLSW 1166
FFASVRSGGSSQVYFMTL R +++W
Sbjct: 1287 FFASVRSGGSSQVYFMTLNRNCIMNW 1312
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1287 bits (3331), Expect = 0.0
Identities = 747/1360 (54%), Positives = 878/1360 (64%), Gaps = 222/1360 (16%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEY------EYSGSEEEEEE------VP-------------- 334
QLKDHIDR+RKKRGEK+ETEY E S EE E VP
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 335 -----------------EQEGEPSSIVN-------------------VPGESTLRRDFLR 358
+Q+ +P + + V + R+ +
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 359 LQQENKERS----EALRRQQLLQEQQLREQEEYKRQLLAERQK--RIEQQKEQRRRLEEQ 412
LQ++ ++R +ALRR++ + +Q ++EYKR+ L E+++ R+++Q +Q +
Sbjct: 421 LQEKEQQRRLEDMQALRREE--ERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKS 478
Query: 413 QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE---RRRAEEEKRRVEREQEYIR 469
+++++ ++ Q+++Q++ +++ L R ++ R EE R +++ +
Sbjct: 479 LQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLA 538
Query: 470 R------------------------QLEEEQRHLEVLQ--QQLLQEQAMLLHDHRRPHPQ 503
+ Q QR +E + + L + L + P P+
Sbjct: 539 KSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPR 598
Query: 504 -HSQQPPPPQQERSKPSFHAPEP----------------KAHYEPADRA----------- 535
S Q P + + P+ H P+P + + +P
Sbjct: 599 SQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWV 658
Query: 536 ---REVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLVPRP 591
E P + R+ ++ + G + +QA + R ++S L R E+ P+P
Sbjct: 659 RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKP 718
Query: 592 GSGSSS--GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSKSEGS 631
+ G N+ S P S PG Q+GS ER RV SSK + S
Sbjct: 719 PGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSS 778
Query: 632 PSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESG 691
P N K P+D + RP +PA V L KE E RPP K DYSSSSEE
Sbjct: 779 PVLSPGNKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV- 830
Query: 692 TTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKE 751
E +D E+EG G DT S +G+T+SV TM+VHD E P
Sbjct: 831 ---ESSEDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGG 883
Query: 752 GTLIVRQTQSA--------------------------------------------SSTLQ 767
GT++V++T S L
Sbjct: 884 GTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLV 943
Query: 768 KHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPT 826
K SSFT F+D + Q S + +T++VG +G R + ++ D RKGSVVNVNPT
Sbjct: 944 KAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPT 1000
Query: 827 NTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRF 886
NTR S+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRF
Sbjct: 1001 NTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRF 1060
Query: 887 QQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYK 946
QQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+
Sbjct: 1061 QQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYR 1120
Query: 947 VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVI 1006
VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVI
Sbjct: 1121 VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVI 1180
Query: 1007 YGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYED 1066
YGS AGFHAVDVDSG+ YDIY+P H IQ I PHAII LPNTDGME+L+CYED
Sbjct: 1181 YGSSAGFHAVDVDSGNSYDIYIPVH--------IQSQITPHAIIFLPNTDGMEMLLCYED 1232
Query: 1067 EGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKR 1126
EGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1233 EGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1292
Query: 1127 AQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
AQRLKFLCERNDKVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1293 AQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 402 bits (1034), Expect = e-112
Identities = 241/591 (40%), Positives = 330/591 (55%), Gaps = 101/591 (17%)
Query: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60
DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
Query: 61 -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG QLW+VME C
Sbjct: 74 KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
Query: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169
AGS+TD+V+ T +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
Query: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229
VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+WS GITAIEMAEG
Sbjct: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
Query: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
APPLC++ P+ ALF+I R P +KS WS+KF +F+E C +KN++ RP++ +L+HPF+
Sbjct: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
Query: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQ------------- 336
RD NER V L H+ KKR +K E EE + EQ
Sbjct: 314 RDIKNERHVVESLTRHLTGIIKKRQKKG-----IPLIFEREEAIKEQYTVRRFRGPSCTH 368
Query: 337 -----------------EGEPSSIVNVPGEST-----------LRRDFLRLQ------QE 362
GEPS +P R F+ LQ +
Sbjct: 369 ELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKP 428
Query: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR------LEEQQRRE 416
K +++A +R Q + Q + K + Q +I+ RR L+ Q R
Sbjct: 429 LKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAP 488
Query: 417 REARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476
R + Q + ++++ Q + ++L++ +E + + + E++R+ + E++Q
Sbjct: 489 RLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAP--------EQQQ 540
Query: 477 RHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKA 527
RH +V +Q+L Q QA P+ +Q P Q ++ A EP++
Sbjct: 541 RHNQVPEQELEQNQA-------PEQPEVQEQAAEPAQAETE----AEEPES 580
Score = 279 bits (714), Expect = 1e-74
Identities = 158/432 (36%), Positives = 241/432 (55%), Gaps = 66/432 (15%)
Query: 787 SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 844
SPS G+ +++ F+ + + ++ ++ S VNVNP P P I Y+K F
Sbjct: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
Query: 845 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 904
SEI C +LWGVNLL+GT S L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG
Sbjct: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
Query: 905 KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 956
K++LRVY+L+WLRNKIL+NDPE +++Q + L GC H+ V+++E ++
Sbjct: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
Query: 957 VIALKSSVEVYAWAPK---------------------------------------PYHKF 977
IALKSS+ +YAWAPK P ++F
Sbjct: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
Query: 978 ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1028
+ K F L HKP+ VDL + +RLK+ + S G+H +D +S + D+ L
Sbjct: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
Query: 1029 PTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEM 1088
P KNP + I P IIILP+ G+ +++ + E + V ++ K ++ W ++
Sbjct: 1449 P----KNPLEI----IIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI 1500
Query: 1089 PTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1148
P+S+A+ + +T GWG+KAIE+RS+++ L+ + ++L+FLC R DK+FF S
Sbjct: 1501 PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN 1560
Query: 1149 GSSQVYFMTLGR 1160
S+VYFMTLG+
Sbjct: 1561 HHSRVYFMTLGK 1572
Score = 36.6 bits (83), Expect = 0.14
Identities = 81/374 (21%), Positives = 130/374 (34%), Gaps = 55/374 (14%)
Query: 376 LQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEK 435
L LR + L Q +E R + +Q RE++++ R+ + K
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
Query: 436 RRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLH 495
R R E+ E E ++R +R E I Q EEE R ++ ++ + + H
Sbjct: 703 R-FRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFH 761
Query: 496 DHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSP 555
+ Q E KP P+ E +R+ VP
Sbjct: 762 SIQAE----------VQIEPLKPYISNPKK---IEVQERSPSVP---------------- 792
Query: 556 LQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSG 615
A +SS+ R L E+ +K + S + S S+
Sbjct: 793 -----NNQDHAHHVKFSSSVPQRSLLEQAQKPID---IRQRSSQNRQNWLAASESSSEEE 844
Query: 616 SGERFRVRSSSKSEGSPSQRLENAVKKPEDKK--EVFRPLKPAGE-VDLTALAKELR--- 669
S R SS + Q+L + P+ K ++ P+ E V AL++ R
Sbjct: 845 SPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFRNDW 904
Query: 670 --AVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDT--RAASSLNLSN 725
++PP + DY + S TD +DD DES EDT A + +L N
Sbjct: 905 LTPAPVIQPPEEDGDYVELYDASADTDGDDD-------DESNDTFEDTYDHANGNDDLDN 957
Query: 726 GETESVKTMIVHDD 739
++ HDD
Sbjct: 958 QVDQANDVCKDHDD 971
Score = 33.5 bits (75), Expect = 1.2
Identities = 37/120 (30%), Positives = 53/120 (44%), Gaps = 18/120 (15%)
Query: 352 LRRDFLRLQQENKERSEALRRQQLLQE-----------QQLREQEEYK---RQLLAERQK 397
L RD LR N S+ L Q L E +Q RE++ RQ LA+R
Sbjct: 643 LSRDLLRAPNSNN--SKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
Query: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
+ + R E+ + + EARRQ R QRR E + EEL + K++E+ +E
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQ--RRQRRWEDIFNQHEEELRQVDKDKEDESSDNDE 758
Score = 31.6 bits (70), Expect = 4.6
Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 13/130 (10%)
Query: 370 LRRQQLLQEQQLREQEEYKRQLLAERQK--RIEQQKEQRRRLEEQQRREREARRQQEREQ 427
+R +LLQ Q +++ + +E Q ++ ++ + + ++ EQQ R+ +A QQ+R
Sbjct: 485 VRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ-RQGQAPEQQQRHN 543
Query: 428 RRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLL 487
+ EQE LE+ + + E + + AE + E E+ E + + +V L
Sbjct: 544 QVPEQE----LEQNQAPEQPEVQEQAAEPAQAETEAEEP------ESLRVNAQVFLPLLS 593
Query: 488 QEQAMLLHDH 497
Q+ +LL H
Sbjct: 594 QDHHVLLPLH 603
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (783), Expect = 1e-82
Identities = 157/311 (50%), Positives = 206/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREI 137
N+ +YG + KK + D+LWLV+E C GS+TDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH + IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WS GITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K+Y +RP+ +LL+H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 RKKRGEKDETE 320
K R E+ T+
Sbjct: 315 EKARRERIHTK 325
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 8e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 8e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 269 bits (688), Expect = 1e-71
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
Query: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
Score = 33.1 bits (74), Expect = 1.6
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 678 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 733
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
Query: 734 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 773
MI HDD PS+ GT+++ K + +
Sbjct: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 267 bits (683), Expect = 4e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
Query: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
Query: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
Query: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
Query: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
Query: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
D + Y ++ E V S+ NV E T
Sbjct: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 259 bits (663), Expect = 8e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
Query: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
Query: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
Query: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
Query: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 7e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 7e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 252 bits (644), Expect = 1e-66
Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++D+WS GITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
SK F F+E CL K+ RP+ ++LLKH FI + +L D R K
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
Query: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347
E E S SE+ + + ++GE I P
Sbjct: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 248 bits (633), Expect = 2e-65
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
Query: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
Query: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
Query: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
Query: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
Query: 314 GEKDETEYEYSGSEEEEEE 332
DE++ E S SE E
Sbjct: 299 HSDDESDSEGSDSESTSRE 317
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 297 EQSHDDSSSEDSDAETDGQ 315
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 308
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 309 EQSHDDSSSEDSDAETDGQ 327
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 241 bits (616), Expect = 2e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
Query: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 239 bits (609), Expect = 1e-62
Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)
Query: 10 LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69
+VD D+ + RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ +
Sbjct: 3 VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
Query: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
++ K H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E
Sbjct: 62 EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
Query: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
I+Y+ RE+L+GLA+LH IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FI
Sbjct: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
Query: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248
GTPYWMAPEV A Y+ D+WS GITAIE+AE PPL D+HP+R LFL+ ++
Sbjct: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
Query: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306
PPRLK K KWS F +FI+ L K+ +RPS ++L H + R + + L D +
Sbjct: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
Query: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360
K D E+EE E+P + SS + +P RR +
Sbjct: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389
E +L + LR K+
Sbjct: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
Score = 34.7 bits (78), Expect = 0.54
Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 857 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 916
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
Query: 917 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 963
N I H P K T + D +GC V + FL AL++S
Sbjct: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
Query: 964 VEVYAWAPKPYHKFM 978
V + W +P +KF+
Sbjct: 631 VVLLQWY-QPMNKFL 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,756,480
Number of Sequences: 37866
Number of extensions: 2617510
Number of successful extensions: 85610
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1893
Number of HSP's successfully gapped in prelim test: 1486
Number of HSP's that attempted gapping in prelim test: 17945
Number of HSP's gapped (non-prelim): 22305
length of query: 1166
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1053
effective length of database: 13,968,660
effective search space: 14708998980
effective search space used: 14708998980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.