Search of human proteins with 218749883

Search of human proteins with 218749883

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218749883 alpha 1,2-mannosidase [Homo sapiens]
         (699 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218749883 alpha 1,2-mannosidase [Homo sapiens]                    1445   0.0  
gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]     327   2e-89
gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]      325   1e-88
gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]      319   5e-87
gi|163310725 ER degradation enhancer, mannosidase alpha-like 3 [...   201   2e-51
gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Ho...   188   2e-47
gi|222537737 ER degradation enhancer, mannosidase alpha-like 2 i...   173   6e-43
gi|222537739 ER degradation enhancer, mannosidase alpha-like 2 i...   155   1e-37
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     41   0.003
gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]              40   0.006
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    40   0.006
gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]        38   0.028
gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens]        38   0.028
gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Ho...    38   0.036
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    37   0.062
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]            37   0.062
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    37   0.062
gi|9945318 MAX binding protein [Homo sapiens]                          37   0.081
gi|41406097 dishevelled 3 [Homo sapiens]                               37   0.081
gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]          37   0.081
gi|110349719 titin isoform N2-A [Homo sapiens]                         36   0.11 
gi|157671951 solute carrier family 4, anion exchanger, member 3 ...    36   0.11 
gi|157671953 solute carrier family 4, anion exchanger, member 3 ...    36   0.11 
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    35   0.18 
gi|157738619 smoothelin-like 1 [Homo sapiens]                          35   0.18 
gi|91208420 bassoon protein [Homo sapiens]                             35   0.24 
gi|18959210 WIRE protein [Homo sapiens]                                35   0.24 
gi|58082089 hypothetical protein LOC161394 [Homo sapiens]              35   0.24 
gi|119943102 CREB binding protein isoform b [Homo sapiens]             35   0.31 
gi|119943104 CREB binding protein isoform a [Homo sapiens]             35   0.31 

>gi|218749883 alpha 1,2-mannosidase [Homo sapiens]
          Length = 699

 Score = 1445 bits (3740), Expect = 0.0
 Identities = 699/699 (100%), Positives = 699/699 (100%)

Query: 1   MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY 60
           MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
Sbjct: 1   MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY 60

Query: 61  DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK 120
           DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
Sbjct: 61  DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK 120

Query: 121 MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG 180
           MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
Sbjct: 121 MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG 180

Query: 181 TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ 240
           TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
Sbjct: 181 TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ 240

Query: 241 GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI 300
           GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
Sbjct: 241 GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI 300

Query: 301 LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN 360
           LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
Sbjct: 301 LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN 360

Query: 361 RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA 420
           RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
Sbjct: 361 RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA 420

Query: 421 VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE 480
           VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
Sbjct: 421 VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE 480

Query: 481 TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG 540
           TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
Sbjct: 481 TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG 540

Query: 541 LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET 600
           LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
Sbjct: 541 LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET 600

Query: 601 VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF 660
           VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
Sbjct: 601 VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF 660

Query: 661 LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA 699
           LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
Sbjct: 661 LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA 699


>gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]
          Length = 653

 Score =  327 bits (838), Expect = 2e-89
 Identities = 211/635 (33%), Positives = 338/635 (53%), Gaps = 50/635 (7%)

Query: 80  RLQRNMILFLL--AFLLFC-GLLFYINLADHWKALAFRLEEEQKMRPEIAGLKPANPPVL 136
           RL    +L L+  AF+  C G +F+             L +  K+   ++G+   + P L
Sbjct: 37  RLTEKFVLLLVFSAFITLCFGAIFF-------------LPDSSKL---LSGVLFHSSPAL 80

Query: 137 PAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG------TQEEATKRQE 190
                    P    E +++   R  + G P      P   L+D         E A +  +
Sbjct: 81  QPAADHKPGPGARAEDAAEGRARRREEGAPG----DPEAALEDNLARIRENHERALREAK 136

Query: 191 APVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAE-VPTKPPLPPARTQGTPVHLNYR 249
             +   PE + QR ++  +  V + +   + P R    V   PP+     +     +  +
Sbjct: 137 ETLQKLPE-EIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREK 195

Query: 250 QKGVIDVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG--LGLTLIDALDTMWILGLRK 305
           +  + ++  HAW  Y+ +AWG +ELKP+S+    S  FG   G T++DALDT++I+ ++ 
Sbjct: 196 RAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKH 255

Query: 306 EFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPA 365
           EFEEA+ WV + L F  + ++++FE  IR +GGLLSAY+LSG+ +F +KA + G +L+PA
Sbjct: 256 EFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPA 315

Query: 366 FRTPSKIPYSDVNIGTGVAHPPRWTS--DSTVAEVTSIQLEFRELSRLTGDKKFQEAVEK 423
           F TPS IP++ +N+ +G+     W S   S +AE  ++ LEF  LS L+G+  F E V  
Sbjct: 316 FHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKVMN 375

Query: 424 VTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQL 483
           +   ++ L  K  GL P ++N  SG +    V ++G   DS+YEYLLK W+   K + + 
Sbjct: 376 IRTVLNKLE-KPQGLYPNYLNPSSGQWGQHHV-SVGGLGDSFYEYLLKAWLMSDKTDLEA 433

Query: 484 LEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALG---VYHG 540
            + Y +A++ + THL+R S  S LT++ E   G    KM HL CF  G  ALG      G
Sbjct: 434 KKMYFDAVQAIETHLIRKSS-SGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEG 492

Query: 541 LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET 600
           +   ++EL  E+  TC++   +    L PE   F+     G   +  +  +++ +LRPE 
Sbjct: 493 MAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFD----GGVEAIATRQNEKYYILRPEV 548

Query: 601 VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF 660
           +E+  Y++R+T D KY+ W WE +++     RV +GGYS + +V    +    D  +SFF
Sbjct: 549 METYMYMWRLTHDPKYRKWAWEAVEALENHCRV-NGGYSGLRDVYLLHESYD-DVQQSFF 606

Query: 661 LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
           L ETLKYL+L+FSDD +LL L+ ++FN+EAH LPI
Sbjct: 607 LAETLKYLYLIFSDD-DLLPLEHWIFNSEAHLLPI 640


>gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]
          Length = 641

 Score =  325 bits (832), Expect = 1e-88
 Identities = 216/635 (34%), Positives = 329/635 (51%), Gaps = 71/635 (11%)

Query: 85  MILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQKMRPEI-AGLKPANPPVL----PAP 139
           ++L L AF+  C   F+  L D  K   F L  E  + P + AG    NP V     P  
Sbjct: 39  LLLILSAFITLCFGAFFF-LPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDE 97

Query: 140 QKADTDPENLPEISSQKTQRHIQRGPPHL-----QIRPPSQDLKDGTQEEATKRQEAPVD 194
            +   + E L        ++ ++     L     +IR   Q  K+   +E   ++  P+ 
Sbjct: 98  HRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLP 157

Query: 195 PRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQKGVI 254
           P P  +    ++  RG   +PE                             +  +++ + 
Sbjct: 158 PVPIPN----LVGIRGG--DPEDND--------------------------IREKREKIK 185

Query: 255 DVFLHAWKGYRKFAWGHDELKPVSRS--FSEWFG---LGLTLIDALDTMWILGLRKEFEE 309
           ++  HAW  YR + WGH+EL+P++R       FG   +G T++DALDT++I+GL  EF +
Sbjct: 186 EMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLD 245

Query: 310 ARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFRTP 369
            ++W+   L F  + +V++FE  IR +GGLL+AY+LSG+ +F  KA     +L+PAF TP
Sbjct: 246 GQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTP 305

Query: 370 SKIPYSDVNIGTGVAHPPRWTS--DSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQH 427
           + IP++ VN+ +GV     W S   S +AE  ++ +EF  LS LTGD  + + V     H
Sbjct: 306 TGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKV----MH 361

Query: 428 IHGLSGKKD---GLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLL 484
           I  L  K D   GL P ++N  +G +      ++G   DS+YEYLLK W+   K + +  
Sbjct: 362 IRKLLQKMDRPNGLYPNYLNPRTGRWGQYHT-SVGGLGDSFYEYLLKAWLMSDKTDHEAR 420

Query: 485 EDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLPAS 544
           + Y +AIE +  HL++ S    LTF+GE  +G    KM HL CF  G  ALG   G  A 
Sbjct: 421 KMYDDAIEAIEKHLIKKSR-GGLTFIGEWKNGHLEKKMGHLACFAGGMFALGA-DGSRAD 478

Query: 545 ----HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET 600
               ++EL  E+  TC++   +    L PE   F+         V V+ A+++ +LRPE 
Sbjct: 479 KAGHYLELGAEIARTCHESYDRTALKLGPESFKFD----GAVEAVAVRQAEKYYILRPEV 534

Query: 601 VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF 660
           +E+ +YL+R T D +Y+ WGWE   +  ++ RV +GG+S + +V     P   D  +SFF
Sbjct: 535 IETYWYLWRFTHDPRYRQWGWEAALAIEKYCRV-NGGFSGVKDVYS-STPTHDDVQQSFF 592

Query: 661 LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
           L ETLKYL+LLFS D +LL LD +VFNTEAHPLP+
Sbjct: 593 LAETLKYLYLLFSGD-DLLPLDHWVFNTEAHPLPV 626


>gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]
          Length = 630

 Score =  319 bits (818), Expect = 5e-87
 Identities = 223/631 (35%), Positives = 341/631 (54%), Gaps = 60/631 (9%)

Query: 86  ILFLLAFLLFC-GLLFYINLADHWKALAFRLEEEQ---KMRPEIAGLKPAN---PPVLPA 138
           +LFL   +  C G LF +  +   K L      +Q   ++  EIAG  PA    PP  PA
Sbjct: 26  LLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPA 85

Query: 139 PQK---ADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVD- 194
           P      + DP +    S ++ +  ++R  P             G +EEAT  +   +  
Sbjct: 86  PAAPAPGEDDPSSWA--SPRRRKGGLRRTRP------------TGPREEATAARGNSIPA 131

Query: 195 --PRPEGDPQRTVIS-WRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVHLNYRQK 251
             P  EG P R   + +R  +  P  GT     RA+  ++ P    R Q        R+K
Sbjct: 132 SRPGDEGVPFRFDFNAFRSRLRHPVLGT-----RAD-ESQEPQSQVRAQ--------REK 177

Query: 252 GVIDVFLHAWKGYRKFAWGHDELKPVSRSFSE--WFG--LGLTLIDALDTMWILGLRKEF 307
            + ++   AW+ Y+++A G +EL+P+++   E   FG   G T+ID+LDT++++ L++EF
Sbjct: 178 -IKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEF 236

Query: 308 EEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGNRLMPAFR 367
           +EA+ WV +  H     + +LFE  IR +GGLLSA++L+G+ +F  KA   G +L+PAF 
Sbjct: 237 QEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFN 296

Query: 368 TPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQH 427
           TP+ IP   V+  +G        S S +AE  S+ LEF  L+ L+G++ F E V  + + 
Sbjct: 297 TPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKV 356

Query: 428 IHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDY 487
           +  +  K  GL P F++  SG +    V ++G   DS+YEYL+K W+  GK + +    Y
Sbjct: 357 LRKIE-KPFGLYPNFLSPVSGNWVQHHV-SVGGLGDSFYEYLIKSWLMSGKTDMEAKNMY 414

Query: 488 VEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHGLP---AS 544
            EA+E + T+LL  S P  LT++ E   G    KM HL CF  G +ALG         A 
Sbjct: 415 YEALEAIETYLLNVS-PGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAH 473

Query: 545 HMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPETVESL 604
           + ELA ++ +TC++   + +T L PE   FN     GR  V  + ++ + +LRPE VES 
Sbjct: 474 YRELAAQITKTCHESYARSDTKLGPEAFWFN----SGREAVATQLSESYYILRPEVVESY 529

Query: 605 FYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFFLGET 664
            YL+R T +  Y++WGWE++ +  ++ R    G+S I +V     P   +K +SFFL ET
Sbjct: 530 MYLWRQTHNPIYREWGWEVVLALEKYCRT-EAGFSGIQDVYS-STPNHDNKQQSFFLAET 587

Query: 665 LKYLFLLFSDDPNLLSLDAYVFNTEAHPLPI 695
           LKYL+LLFS+D +LLSL+ +VFNTEAHPLP+
Sbjct: 588 LKYLYLLFSED-DLLSLEDWVFNTEAHPLPV 617


>gi|163310725 ER degradation enhancer, mannosidase alpha-like 3
           [Homo sapiens]
          Length = 932

 Score =  201 bits (510), Expect = 2e-51
 Identities = 152/475 (32%), Positives = 239/475 (50%), Gaps = 62/475 (13%)

Query: 253 VIDVFLHAWKGYRKFAWGHDELKPVS------------RSFSEWFG-LGLTLIDALDTMW 299
           V+++F HA+  Y + A+  DEL P++                +  G   LTLID+LDT+ 
Sbjct: 56  VLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLV 115

Query: 300 ILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLS------GDSL--- 350
           +L   KEFE+A + V + ++ + DV V++FE+ IR+LGGLL  + L+      G+ +   
Sbjct: 116 VLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWY 175

Query: 351 ---FLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWT---SDSTVAEVTSIQLE 404
               L+ A+  G +L+PAF T S +PY  +N+  G+  P   T   +D+  A   ++ LE
Sbjct: 176 NDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILE 235

Query: 405 FRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADS 464
           F  LSR TG   F+E   K    +     +   LV + IN H+G +       +GA  DS
Sbjct: 236 FAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKD-SGVGAGIDS 294

Query: 465 YYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAK--M 522
           YYEYLLK ++  G  +   LE +    + +  ++   S+P  L  V  +     +A+  M
Sbjct: 295 YYEYLLKAYVLLG--DDSFLERFNTHYDAIMRYI---SQPPLLLDV-HIHKPMLNARTWM 348

Query: 523 DHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGR 582
           D L+ F PG   L          +  A E  E  YQ+           I   N  P+   
Sbjct: 349 DALLAFFPGLQVL-------KGDIRPAIETHEMLYQV-----------IKKHNFLPEAFT 390

Query: 583 RDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSIN 642
            D  V  A   + LRPE  ES ++LY+ TGD  Y + G  ++++ +++ RVP G      
Sbjct: 391 TDFRVHWA--QHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCG----FA 444

Query: 643 NVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPNLL-SLDAYVFNTEAHPLPIW 696
            ++D +     D+M+SFFL E  KYL+LLF+D  +++  ++ Y+F TEAH LP+W
Sbjct: 445 AMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLW 499


>gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Homo
           sapiens]
          Length = 657

 Score =  188 bits (477), Expect = 2e-47
 Identities = 158/474 (33%), Positives = 230/474 (48%), Gaps = 66/474 (13%)

Query: 256 VFLHAWKGYRKFAWGHDELKPV-------------SRSFSEWFG-LGLTLIDALDTMWIL 301
           +F+  +  Y   A+  DEL P+             + + ++  G   LTL+DALDT+ I+
Sbjct: 137 MFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIM 196

Query: 302 GLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSL----------- 350
           G   EF++A K V   + F+KD  V +FE+TIR+LG LLSA+ +  DS            
Sbjct: 197 GNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDY 256

Query: 351 ---FLRKAEDFGNRLMPAF-RTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFR 406
               L  A D   RL+PAF  T + IPY  VN+ TGV  PP   +++  A   S+ +EF 
Sbjct: 257 DNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGV--PPDTNNETCTAGAGSLLVEFG 314

Query: 407 ELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYY 466
            LSRL GD  F+    +  + +  L     GL+   +N  +G +       LGA  DS+Y
Sbjct: 315 ILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVG-KQSGLGAGLDSFY 373

Query: 467 EYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLR--------HSEPSKLTFVGELAHGRF 518
           EYLLK +I  G++E   LE +  A + ++ +L R          +P     V   +    
Sbjct: 374 EYLLKSYILFGEKED--LEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLM 431

Query: 519 SAKMDHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYP 578
           +  +D L  F PG   L          +E A  L    Y + ++   G  PE  ++ L  
Sbjct: 432 NTWIDSLQAFFPGLQVL-------IGDVEDAICLHAFYYAIWKRY--GALPERYNWQLQA 482

Query: 579 QPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGY 638
                DV   P      LRPE VES + LY+ T +  Y   G +ILQS  ++T+V   GY
Sbjct: 483 P----DVLFYP------LRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKC-GY 531

Query: 639 SSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDD-PNLLSLDAYVFNTEAH 691
           +++++V D       D+MESFFL ET KYL+LLF +D P   S   Y+F TE H
Sbjct: 532 ATLHHVID---KSTEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGH 582


>gi|222537737 ER degradation enhancer, mannosidase alpha-like 2
           isoform 1 [Homo sapiens]
          Length = 578

 Score =  173 bits (438), Expect = 6e-43
 Identities = 152/492 (30%), Positives = 236/492 (47%), Gaps = 68/492 (13%)

Query: 236 PARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVS-RSFSEWFGLGLTLIDA 294
           P      P   +YR++ V  +F HA+  Y + A+  DEL+P++      W    LTLIDA
Sbjct: 23  PGPDGSAPDPAHYRER-VKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDA 81

Query: 295 LDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSG------- 347
           LDT+ ILG   EF+   + +   + F+ DV+ ++FE+ IR++GGLLSA+ LS        
Sbjct: 82  LDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVE 141

Query: 348 -----DSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQ 402
                    LR AE+   +L+PAF+TP+ +PY  VN+  GV   P  T  +  A + +  
Sbjct: 142 AGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV--NPGETPVTCTAGIGTFI 199

Query: 403 LEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARA 462
           +EF  LS LTGD  F++        +   S    GLV   I+  +G +       +GA  
Sbjct: 200 VEFATLSSLTGDPVFEDVARVALMRLWE-SRSDIGLVGNHIDVLTGKWVAQDA-GIGAGV 257

Query: 463 DSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKM 522
           DSY+EYL+K  I    Q+ +L+  ++E  + +R     ++         ++  G  S  +
Sbjct: 258 DSYFEYLVKGAIL--LQDKKLMAMFLEYNKAIR----NYTRFDDWYLWVQMYKGTVSMPV 311

Query: 523 -DHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPG 581
              L  + PG  +L          ++ A       Y + +Q   G  PE      Y  P 
Sbjct: 312 FQSLEAYWPGLQSL-------IGDIDNAMRTFLNYYTVWKQF--GGLPE-----FYNIPQ 357

Query: 582 RRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSI 641
              VE +       LRPE +ES  YLYR TGD    + G + ++S  + ++V   G+++I
Sbjct: 358 GYTVEKREG---YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVEC-GFATI 413

Query: 642 NNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPN--------------------LLSL 681
            +++D +     ++MESFFL ET+KYL+LLF  DP                     +L  
Sbjct: 414 KDLRDHKLD---NRMESFFLAETVKYLYLLF--DPTNFIHNNGSTFDAVITPYGECILGA 468

Query: 682 DAYVFNTEAHPL 693
             Y+FNTEAHP+
Sbjct: 469 GGYIFNTEAHPI 480


>gi|222537739 ER degradation enhancer, mannosidase alpha-like 2
           isoform 2 [Homo sapiens]
          Length = 541

 Score =  155 bits (392), Expect = 1e-37
 Identities = 137/442 (30%), Positives = 212/442 (47%), Gaps = 66/442 (14%)

Query: 285 FGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYH 344
           +   LTLIDALDT+ ILG   EF+   + +   + F+ DV+ ++FE+ IR++GGLLSA+ 
Sbjct: 35  YSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHL 94

Query: 345 LSG------------DSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSD 392
           LS                 LR AE+   +L+PAF+TP+ +PY  VN+  GV   P  T  
Sbjct: 95  LSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV--NPGETPV 152

Query: 393 STVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTH 452
           +  A + +  +EF  LS LTGD  F++        +   S    GLV   I+  +G +  
Sbjct: 153 TCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWE-SRSDIGLVGNHIDVLTGKWVA 211

Query: 453 LGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGE 512
                +GA  DSY+EYL+K  I    Q+ +L+  ++E  + +R     ++         +
Sbjct: 212 QDA-GIGAGVDSYFEYLVKGAIL--LQDKKLMAMFLEYNKAIR----NYTRFDDWYLWVQ 264

Query: 513 LAHGRFSAKM-DHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEI 571
           +  G  S  +   L  + PG  +L          ++ A       Y + +Q   G  PE 
Sbjct: 265 MYKGTVSMPVFQSLEAYWPGLQSL-------IGDIDNAMRTFLNYYTVWKQF--GGLPE- 314

Query: 572 VHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFT 631
                Y  P    VE +       LRPE +ES  YLYR TGD    + G + ++S  + +
Sbjct: 315 ----FYNIPQGYTVEKREG---YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKIS 367

Query: 632 RVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPN-------------- 677
           +V   G+++I +++D +     ++MESFFL ET+KYL+LLF  DP               
Sbjct: 368 KVEC-GFATIKDLRDHKLD---NRMESFFLAETVKYLYLLF--DPTNFIHNNGSTFDAVI 421

Query: 678 ------LLSLDAYVFNTEAHPL 693
                 +L    Y+FNTEAHP+
Sbjct: 422 TPYGECILGAGGYIFNTEAHPI 443


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 33/124 (26%), Positives = 44/124 (35%), Gaps = 3/124 (2%)

Query: 123 PEIAGLKPANPPVLPAPQ--KADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG 180
           P   G KP  PP    PQ      D    P     K Q    +G    Q  PP      G
Sbjct: 82  PPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 141

Query: 181 TQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPART 239
              +   + + P  P +P+G P +     R +   P +    P +    P  PP PP + 
Sbjct: 142 PPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKP 201

Query: 240 QGTP 243
           QG P
Sbjct: 202 QGPP 205



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 33/127 (25%), Positives = 48/127 (37%), Gaps = 8/127 (6%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPP-----HLQIRPPSQDL 177
           P   G KP  PP    PQ      +N  +  S ++     +GPP       Q  PP    
Sbjct: 205 PPQGGNKPQGPPPPGKPQGPPPQGDNKSQ--SARSPPGKPQGPPPQGGNQPQGPPPPPGK 262

Query: 178 KDGTQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPP 236
             G   +   + + P  P +P+G P +     R +   P +    P +    P  PP PP
Sbjct: 263 PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPP 322

Query: 237 ARTQGTP 243
            + QG P
Sbjct: 323 GKPQGPP 329



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 34/122 (27%), Positives = 43/122 (35%), Gaps = 19/122 (15%)

Query: 123 PEIAGLKPANPPVLPA-PQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGT 181
           P   G KP  PP  P  PQ       N P+            GPP    +P     + G 
Sbjct: 40  PPQGGNKPQGPPSPPGKPQGPPPQGGNQPQ------------GPPPPPGKPQGPPPQGGN 87

Query: 182 QEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQG 241
           + +       P  P P+GD  R+  S  G    P      P +    P  PP PP + QG
Sbjct: 88  KPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP------PPQGGNQPQGPPPPPGKPQG 141

Query: 242 TP 243
            P
Sbjct: 142 PP 143



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 33/125 (26%), Positives = 45/125 (36%), Gaps = 4/125 (3%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQ---KTQRHIQRGPPHLQIRPPSQDLKD 179
           P   G KP  PP    PQ      +N    S     K Q    +G    Q  PP      
Sbjct: 143 PPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 202

Query: 180 GTQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPAR 238
           G   +   + + P  P +P+G P +     + A   P +    P +    P  PP PP +
Sbjct: 203 GPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGK 262

Query: 239 TQGTP 243
            QG P
Sbjct: 263 PQGPP 267



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 32/121 (26%), Positives = 45/121 (37%), Gaps = 9/121 (7%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPP-----HLQIRPPSQDL 177
           P   G KP  PP    PQ     P+   +  S ++     +GPP       Q  PP    
Sbjct: 267 PPQGGNKPQGPPPPGKPQ--GPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGK 324

Query: 178 KDGTQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPP 236
             G   +   + + P  P +P+G P +     R A   P +    P +    P  PP PP
Sbjct: 325 PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP-PP 383

Query: 237 A 237
           A
Sbjct: 384 A 384


>gi|32307128 nuclear receptor coactivator 6 [Homo sapiens]
          Length = 2063

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 15/126 (11%)

Query: 126  AGLKPANPPVLPAPQ--KADTDPENLPEISSQK--------TQRHIQRGPPHL--QIRPP 173
            AGL+ A+ P LP  Q    D     LPE S++          QR +Q+ PP L   + PP
Sbjct: 938  AGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPP 997

Query: 174  SQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQ---GTELPSRRAEVPT 230
             Q  +   Q +  ++Q+ P   +P+   Q+        ++  +Q      LP  +   P 
Sbjct: 998  PQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPP 1057

Query: 231  KPPLPP 236
            + PL P
Sbjct: 1058 RGPLNP 1063



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 43/180 (23%), Positives = 64/180 (35%), Gaps = 35/180 (19%)

Query: 105 ADHWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEI----------SS 154
           +D    L   L  +Q+  P    L P + P+ P       +P N P++            
Sbjct: 214 SDAMDPLLSGLHIQQQSHPS-GSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQ 272

Query: 155 QKTQRHIQRGPPHLQIRPPSQDLK---DGTQEEATKRQEAPVDP----RPEGDPQRTVI- 206
           Q+ Q+  Q+    LQ RPP Q  +    G + + T   + PV P     P G  Q     
Sbjct: 273 QQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQ 332

Query: 207 ----------SWRGAVIEPEQGTELPSR--RAEVPT----KPPLPPARTQGTPVHLNYRQ 250
                      W+ A +      +L +R   A V T     PP P    Q +  H N+ Q
Sbjct: 333 GSLGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQ 392


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 34/124 (27%), Positives = 46/124 (37%), Gaps = 4/124 (3%)

Query: 123 PEIAGLKPANPPVLPAPQ--KADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG 180
           P   G +P  PP    PQ      D    P     K Q    +G    Q  PP      G
Sbjct: 122 PPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 181

Query: 181 TQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPART 239
              +  K+ + P  P +P+G P +   S R +   P +    P +    P  PP PP + 
Sbjct: 182 PPPQGGKKPQGPPPPGKPQGPPPQGDKS-RSSQSPPGKPQGPPPQGGNQPQGPPPPPGKP 240

Query: 240 QGTP 243
           QG P
Sbjct: 241 QGPP 244



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 30/115 (26%), Positives = 42/115 (36%), Gaps = 7/115 (6%)

Query: 129 KPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKR 188
           KP  PP      ++   P   P+    +     Q GPP    +P     + G + +    
Sbjct: 76  KPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQ-GPPPPPGKPQGPPPQGGNRPQGPPP 134

Query: 189 QEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTP 243
              P  P P+GD  R+  S  G    P      P +    P  PP PP + QG P
Sbjct: 135 PGKPQGPPPQGDKSRSPRSPPGKPQGP------PPQGGNQPQGPPPPPGKPQGPP 183



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 25/90 (27%), Positives = 35/90 (38%), Gaps = 6/90 (6%)

Query: 163 RGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELP 222
           +GPP    +P     + G + +       P  P P+GD  R+  S  G    P      P
Sbjct: 48  QGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP------P 101

Query: 223 SRRAEVPTKPPLPPARTQGTPVHLNYRQKG 252
            +    P  PP PP + QG P     R +G
Sbjct: 102 PQGGNQPQGPPPPPGKPQGPPPQGGNRPQG 131



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 33/120 (27%), Positives = 43/120 (35%), Gaps = 8/120 (6%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPH----LQIRPPSQDLK 178
           P   G KP  PP    PQ     P+     SSQ      Q  PP      Q  PP     
Sbjct: 183 PPQGGKKPQGPPPPGKPQ--GPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKP 240

Query: 179 DGTQEEATKRQEAPVDP-RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPA 237
            G   +   + + P  P +P+G P +     + A   P +    P +    P  PP PPA
Sbjct: 241 QGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPP-PPA 299


>gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]
          Length = 755

 Score = 38.1 bits (87), Expect = 0.028
 Identities = 36/126 (28%), Positives = 49/126 (38%), Gaps = 16/126 (12%)

Query: 123 PEIAGLKPANPPVLPAP-QKADTDP-------ENLPEISSQKTQRHIQRGPPHLQIRPPS 174
           P   G   A P + P P  +A TDP        ++P+  +   Q   Q   P L   PP 
Sbjct: 15  PGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPP 74

Query: 175 QDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPL 234
                    E  +  EA V P  E + + +V     A   P+ G ELP   A  P +PP 
Sbjct: 75  PG-------ELARSPEA-VGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPA 126

Query: 235 PPARTQ 240
           P  R +
Sbjct: 127 PEEREE 132


>gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens]
          Length = 560

 Score = 38.1 bits (87), Expect = 0.028
 Identities = 36/126 (28%), Positives = 49/126 (38%), Gaps = 16/126 (12%)

Query: 123 PEIAGLKPANPPVLPAP-QKADTDP-------ENLPEISSQKTQRHIQRGPPHLQIRPPS 174
           P   G   A P + P P  +A TDP        ++P+  +   Q   Q   P L   PP 
Sbjct: 15  PGEGGAGEAEPEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPP 74

Query: 175 QDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPL 234
                    E  +  EA V P  E + + +V     A   P+ G ELP   A  P +PP 
Sbjct: 75  PG-------ELARSPEA-VGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPA 126

Query: 235 PPARTQ 240
           P  R +
Sbjct: 127 PEEREE 132


>gi|37537692 proline-rich protein BstNI subfamily 4 precursor [Homo
           sapiens]
          Length = 247

 Score = 37.7 bits (86), Expect = 0.036
 Identities = 36/118 (30%), Positives = 43/118 (36%), Gaps = 11/118 (9%)

Query: 129 KPANPPVLPAPQKADTDPE-NLPEISSQK--TQRHIQRGPPHLQIRPPSQDLKDGTQEEA 185
           KP  PP     Q   T P    PE    +   Q H    PP    RPP Q    G Q + 
Sbjct: 98  KPERPPPQGGNQSQGTPPPPGKPERPPPQGGNQSHRPPPPPGKPERPPPQG---GNQSQG 154

Query: 186 TKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTP 243
                 P   +PEG P +     R A   P +    P +    P  PP PP + QG P
Sbjct: 155 PP----PHPGKPEGPPPQEGNKSRSARSPPGKPQGPPQQEGNKPQGPP-PPGKPQGPP 207



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 31/123 (25%), Positives = 47/123 (38%), Gaps = 18/123 (14%)

Query: 122 RPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGT 181
           RP+  G +P  PP  P P K    P+  P     ++Q     GPP    +P  +  + G 
Sbjct: 40  RPQ-GGNQPQRPP--PPPGK----PQGPPPQGGNQSQ-----GPPPPPGKPEGRPPQGGN 87

Query: 182 QEEATKRQEA-PVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ 240
           Q +        P  P P+G  Q      +G    P +    P +      +PP PP + +
Sbjct: 88  QSQGPPPHPGKPERPPPQGGNQS-----QGTPPPPGKPERPPPQGGNQSHRPPPPPGKPE 142

Query: 241 GTP 243
             P
Sbjct: 143 RPP 145


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 37.0 bits (84), Expect = 0.062
 Identities = 36/122 (29%), Positives = 44/122 (36%), Gaps = 14/122 (11%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQR------HIQRGPPHLQIRPPS-- 174
           P +A   P  PP  P P      P     + S K  +      H+   PP L + PP   
Sbjct: 213 PVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY 272

Query: 175 QDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPL 234
             LK      A   QE P  P P   P     S R ++  P     LP   +   T PPL
Sbjct: 273 PGLKAEPASPAQDAQEPPAPPPPL--PPYASCSPRASLPAPP----LPGVNSSSETPPPL 326

Query: 235 PP 236
           PP
Sbjct: 327 PP 328


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score = 37.0 bits (84), Expect = 0.062
 Identities = 30/128 (23%), Positives = 50/128 (39%), Gaps = 18/128 (14%)

Query: 130 PANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDL------------ 177
           P   PVLP  ++A   P           Q+    GP  L + PP+ D             
Sbjct: 492 PREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAP 551

Query: 178 KDGTQEEATKRQEAPVDPR-PEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPP 236
               QE  +  Q A +DP+  +  PQ +     G+ +E ++  E   RR+ + +   + P
Sbjct: 552 DSDPQEAESPLQAAAMDPQASDWSPQES-----GSPVETQESPEKAGRRSSLQSPASVAP 606

Query: 237 ARTQGTPV 244
            +  GT +
Sbjct: 607 PQGPGTKI 614


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score = 37.0 bits (84), Expect = 0.062
 Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 16/121 (13%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQ 182
           P   G +   PP  P P K    PE  P     ++Q     GPP    +P     + G Q
Sbjct: 166 PPQGGNQSQGPP--PHPGK----PEGPPPQGGNQSQ-----GPPPRPGKPEGPPPQGGNQ 214

Query: 183 EEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
            +       P   +PEG P +     +G    P +    P +    P +PP PP R QG 
Sbjct: 215 SQGPP----PRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPP-PPGRPQGP 269

Query: 243 P 243
           P
Sbjct: 270 P 270



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 33/121 (27%), Positives = 45/121 (37%), Gaps = 15/121 (12%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQ 182
           P   G +   PP  P P K    PE  P     ++Q     GPP    +P     + G Q
Sbjct: 145 PPQGGNQSQGPP--PRPGK----PEGPPPQGGNQSQ-----GPPPHPGKPEGPPPQGGNQ 193

Query: 183 EEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
            +       P   +PEG P +     +G    P +    PS+    P  PP  P + QG 
Sbjct: 194 SQGPP----PRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGP 249

Query: 243 P 243
           P
Sbjct: 250 P 250



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 32/122 (26%), Positives = 45/122 (36%), Gaps = 15/122 (12%)

Query: 122 RPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGT 181
           RP   G +   PP  P P K    PE  P     ++Q     GPP    +P  Q  + G 
Sbjct: 60  RPPQGGNQSQGPP--PRPGK----PEGPPPQGGNQSQ-----GPPPRPGKPEGQPPQGGN 108

Query: 182 QEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQG 241
           Q +       P   +PEG P +     +G    P +    P +       PP  P + +G
Sbjct: 109 QSQGPP----PRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEG 164

Query: 242 TP 243
            P
Sbjct: 165 PP 166



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 25/104 (24%), Positives = 38/104 (36%), Gaps = 4/104 (3%)

Query: 143 DTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRP---EG 199
           D   E  P + S K +    +G    Q  PP     +G   +   + + P  PRP   EG
Sbjct: 22  DVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQSQGP-PPRPGKPEG 80

Query: 200 DPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTP 243
            P +     +G    P +    P +       PP  P + +G P
Sbjct: 81  PPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPPRPGKPEGPP 124



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 31/122 (25%), Positives = 45/122 (36%), Gaps = 16/122 (13%)

Query: 122 RPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGT 181
           RP+  G +P   P  P P K    PE  P     ++Q     GPP    +P     + G 
Sbjct: 40  RPQ-GGNQPQRTP--PPPGK----PEGRPPQGGNQSQ-----GPPPRPGKPEGPPPQGGN 87

Query: 182 QEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQG 241
           Q +       P   +PEG P +     +G    P +    P +       PP  P + +G
Sbjct: 88  QSQGPP----PRPGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEG 143

Query: 242 TP 243
            P
Sbjct: 144 PP 145



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 30/121 (24%), Positives = 43/121 (35%), Gaps = 15/121 (12%)

Query: 123 PEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQ 182
           P   G +   PP  P P K    PE  P     ++Q     GPP    +P     + G Q
Sbjct: 82  PPQGGNQSQGPP--PRPGK----PEGQPPQGGNQSQ-----GPPPRPGKPEGPPPQGGNQ 130

Query: 183 EEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
            +       P   +PEG P +     +G    P +    P +       PP  P + +G 
Sbjct: 131 SQGPP----PRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKPEGP 186

Query: 243 P 243
           P
Sbjct: 187 P 187


>gi|9945318 MAX binding protein [Homo sapiens]
          Length = 582

 Score = 36.6 bits (83), Expect = 0.081
 Identities = 31/100 (31%), Positives = 40/100 (40%), Gaps = 11/100 (11%)

Query: 164 GPPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVI---EPEQGTE 220
           GPP L  RP  + LK      +T    AP+ P P   P    +      +   +P+Q T 
Sbjct: 351 GPPKLSHRPQPELLKSTLPPPST--TPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTP 408

Query: 221 LPSRRAEVPTKPPLPPART-QGTPVHLNYRQKGVIDVFLH 259
           LP+     P  PP  PA+T    P HL     G   V  H
Sbjct: 409 LPA-----PPPPPAAPAQTLVPAPAHLVATAGGGSTVIAH 443


>gi|41406097 dishevelled 3 [Homo sapiens]
          Length = 716

 Score = 36.6 bits (83), Expect = 0.081
 Identities = 22/52 (42%), Positives = 27/52 (51%), Gaps = 5/52 (9%)

Query: 10  GALGSSQSDFLTP--PVGGAPWAVATTVVMYPPPPPP--PHRDFISVTLSFG 57
           G+ G+S  D L P    G APW +A     YPPPP P  PH  F  +  S+G
Sbjct: 511 GSSGASDQDTLAPLPHPGAAPWPMAFP-YQYPPPPHPYNPHPGFPELGYSYG 561


>gi|210032509 hypothetical protein LOC100130302 [Homo sapiens]
          Length = 887

 Score = 36.6 bits (83), Expect = 0.081
 Identities = 40/141 (28%), Positives = 59/141 (41%), Gaps = 15/141 (10%)

Query: 111 LAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQI 170
           L F L   + +RP      P    VL  PQ+     ++   +S Q+ Q+     PP  Q 
Sbjct: 671 LQFFLNTPEGLRPLTLLQVPQGSAVLTGPQQ-----QSHQLVSLQQLQQPTAAHPP--QP 723

Query: 171 RPPSQDLKDGTQEEATKRQEA----PVDPRP--EGDPQRTVISWRGAVIEPEQGTELPS- 223
            P    L   TQ +A   Q+     P   R   +  PQ  V+S  G+   P+QG +LPS 
Sbjct: 724 GPQGSALGLSTQGQAFPAQQLLKVNPTRARSGLQPQPQPAVLSLLGSAQVPQQGVQLPSV 783

Query: 224 -RRAEVPTKPPLPPARTQGTP 243
            R+ +   +PP    + Q  P
Sbjct: 784 LRQQQPQPQPPKLQLQPQWQP 804


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 32/125 (25%), Positives = 54/125 (43%), Gaps = 14/125 (11%)

Query: 123   PEIAG--LKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG 180
             PEI+   + P  PP    P+K    P  +PE+  +       R P   ++ PP++  +  
Sbjct: 10443 PEISEKIIPPKKPPTKVVPRKEP--PAKVPEVPKKIVVEEKVRVPEEPRV-PPTKVPEVL 10499

Query: 181   TQEEATKRQEAPVDP--RPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPAR 238
               +E    ++ PV P  +PE  P +   + +  V  PE+   +P      P KP +PP +
Sbjct: 10500 PPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVV--PEKKVPVPP-----PKKPEVPPTK 10552

Query: 239   TQGTP 243
                 P
Sbjct: 10553 VPEVP 10557



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 32/134 (23%), Positives = 52/134 (38%), Gaps = 21/134 (15%)

Query: 122   RPEIAGLKPANPPV---------LPAPQKADTDPENLPEISSQKT-QRHIQRGPPHLQIR 171
             +PE+  +K    P          +P P+K +  P  +PE+      ++ +    P     
Sbjct: 10601 KPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPES 10660

Query: 172   PPSQDLKDGTQEEATKRQEAPV--DPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVP 229
             PP +  ++  +E A +   A V  +P P   PQ TV         P++        A V 
Sbjct: 10661 PPPEVFEE-PEEVALEEPPAEVVEEPEPAAPPQVTV--------PPKKPVPEKKAPAVVA 10711

Query: 230   TKPPLPPARTQGTP 243
              KP LPP +    P
Sbjct: 10712 KKPELPPVKVPEVP 10725



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 33/129 (25%), Positives = 54/129 (41%), Gaps = 21/129 (16%)

Query: 118  EQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDL 177
            E+K    +   +PA PP +P   K     E +P   ++K +      PP    + P    
Sbjct: 9326 EEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKE-----APP---AKVPEVQK 9377

Query: 178  KDGTQEE---ATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPL 234
               T+E+    T+R+E+P    PE  P++ V         PE+   +P +  EVP  P +
Sbjct: 9378 GVVTEEKITIVTQREESPPPAVPE-IPKKKV---------PEERKPVPRKEEEVPPPPKV 9427

Query: 235  PPARTQGTP 243
            P    +  P
Sbjct: 9428 PALPKKPVP 9436



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 23/129 (17%)

Query: 129   KPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKR 188
             +PA PP +  P K     +  P + ++K +      PP      P + + +       K+
Sbjct: 10686 EPAAPPQVTVPPKKPVPEKKAPAVVAKKPEL-----PPVKVPEVPKEVVPE-------KK 10733

Query: 189   QEAPVDPRPEGDPQRTVISWRGAVIEPEQGTEL-PSRRAEVPTKPPLPPARTQGTPVHLN 247
                 V  +PE  P +           PE   E+ P ++  VP KP +PPA+    P    
Sbjct: 10734 VPLVVPKKPEAPPAKV----------PEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPV 10783

Query: 248   YRQKGVIDV 256
               +K  + V
Sbjct: 10784 LEEKPAVPV 10792



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 27/110 (24%), Positives = 44/110 (40%), Gaps = 15/110 (13%)

Query: 134   PVLPAPQKADTDP----ENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATK-- 187
             P +P P++A++ P    E   EI+ ++     +  P  +      +       EE  K  
Sbjct: 10788 PAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKII 10847

Query: 188   -RQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPP 236
               ++ PV  +PE  P +          EPE+  E P  +   P  PP PP
Sbjct: 10848 PEKKVPVIKKPEAPPPKEP--------EPEKVIEKPKLKPRPPPPPPAPP 10889



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 7/114 (6%)

Query: 118  EQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDL 177
            E+K+   +A  K A P  +P  QK     E +  +    TQR  +  PP      P + +
Sbjct: 9354 EEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIV----TQR--EESPPPAVPEIPKKKV 9407

Query: 178  KDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTK 231
             +  +    K +E P  P+    P++ V   + AV  P    + P  RAEV  K
Sbjct: 9408 PEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVP-VAKKAPPPRAEVSKK 9460



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 27/134 (20%), Positives = 50/134 (37%), Gaps = 14/134 (10%)

Query: 119   QKMRPEIAGLKPANPP---------VLP-----APQKADTDPENLPEISSQKTQRHIQRG 164
             +K  P +   KP  PP         V+P      P+K +  P  +PE+  +         
Sbjct: 10731 EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAV 10790

Query: 165   PPHLQIRPPSQDLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSR 224
             P   +   P  ++ +  +E A + + AP + +P    +          +  E    +P +
Sbjct: 10791 PVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEK 10850

Query: 225   RAEVPTKPPLPPAR 238
             +  V  KP  PP +
Sbjct: 10851 KVPVIKKPEAPPPK 10864



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 18/137 (13%)

Query: 115   LEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLP--------EISSQKTQRHIQRGPP 166
             L EE+++ PE   + P    VLP  ++   + E +P        E      +  +    P
Sbjct: 10120 LPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVKP 10179

Query: 167   HLQIRPPSQDLKDGTQEEAT---KRQEAP---VDPRPEGDPQRTVISWRGAVIEPEQGTE 220
              + +  P  ++K    E+     K++EAP   V   P+   ++ +I  +   + P + TE
Sbjct: 10180 KVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTE 10239

Query: 221   LPSR----RAEVPTKPP 233
              P        E+P +PP
Sbjct: 10240 EPEEEPISEEEIPEEPP 10256



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 30/122 (24%), Positives = 53/122 (43%), Gaps = 10/122 (8%)

Query: 130   PANPPVLPAPQKADTDPENLPEISSQKTQR------HIQRGPPHLQIRPPSQDL-KDGTQ 182
             P     +P P+K +  P  +PE+  +  ++        ++ PP      P + + ++   
Sbjct: 9959  PEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVP 10018

Query: 183   EEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
                 K+ EAP    PE  P++ V   +  V  P++    P++  EVP K  L P   + T
Sbjct: 10019 VPVPKKVEAPPAKVPE-VPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKK--LIPEEKKPT 10075

Query: 243   PV 244
             PV
Sbjct: 10076 PV 10077



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 25/117 (21%), Positives = 45/117 (38%), Gaps = 4/117 (3%)

Query: 130   PANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDL---KDGTQEEAT 186
             P     +PAP+K +  P  +PE+  +      +  P   ++  P   +   ++       
Sbjct: 10041 PEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVPVA 10100

Query: 187   KRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTP 243
               QE  V    E  P+  V+     V+ PE+   LP     +P +  +PP   +  P
Sbjct: 10101 LPQEEEVLFEEEIVPEEEVLPEEEEVL-PEEEEVLPEEEEVLPEEEEIPPEEEEVPP 10156



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 25/127 (19%)

Query: 130   PANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQ 189
             PA  P  P P+  +   E +PE       + +   PP     PP++  +        K+ 
Sbjct: 10514 PAKKPEAPPPKVPEAPKEVVPE-------KKVPVPPPKKPEVPPTKVPEVPKAAVPEKKV 10566

Query: 190   EAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTK--PPLPPARTQGTPVHLN 247
                + P+PE  P             PE   E+      VP K  P  PP + + TPV + 
Sbjct: 10567 PEAIPPKPESPPPEV----------PEAPKEV------VPEKKVPAAPPKKPEVTPVKVP 10610

Query: 248   YRQKGVI 254
                K V+
Sbjct: 10611 EAPKEVV 10617



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 35/146 (23%), Positives = 52/146 (35%), Gaps = 27/146 (18%)

Query: 116  EEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQ 175
            EE     PE+         +  A  K    P  +PE+  +     +   P   ++ PP  
Sbjct: 9255 EEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPP-- 9312

Query: 176  DLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKP--- 232
                     A K  E P  P PE          +  V  P++    P +  EVP KP   
Sbjct: 9313 ---------APKVPEVPKKPVPEE---------KKPVPVPKKEPAAPPKVPEVPKKPVPE 9354

Query: 233  ---PLPPA-RTQGTPVHLNYRQKGVI 254
               P+P A + +  P  +   QKGV+
Sbjct: 9355 EKIPVPVAKKKEAPPAKVPEVQKGVV 9380



 Score = 29.6 bits (65), Expect = 9.9
 Identities = 27/119 (22%), Positives = 53/119 (44%), Gaps = 15/119 (12%)

Query: 114  RLEEEQKMRPEIAGLKPANPPVLPA-PQKADTDPENLPEISSQKTQRHIQRGPPHLQIRP 172
            ++  E+K+   +   +   PP +P  P+K   + +  P++   +     +    H+QI  
Sbjct: 9586 KIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQI-- 9643

Query: 173  PSQDLKDGTQEE----ATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAE 227
                    TQEE    A  ++EAP   R   +P+R V   +   ++P++  E P++  E
Sbjct: 9644 --------TQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTE 9694


>gi|157671951 solute carrier family 4, anion exchanger, member 3
           isoform 1 [Homo sapiens]
          Length = 1232

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 30/117 (25%), Positives = 44/117 (37%), Gaps = 11/117 (9%)

Query: 136 LPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEA---- 191
           LP P K    P      + +K ++     PP     P  ++   G  EE  + +E     
Sbjct: 89  LPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGES 148

Query: 192 ---PVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVH 245
              PV+P P G PQ+   S      + +    LP R A     P + P  T  +P H
Sbjct: 149 EAEPVEPPPSGTPQKAKFSIGS---DEDDSPGLPGRAAVTKPLPSVGP-HTDKSPQH 201


>gi|157671953 solute carrier family 4, anion exchanger, member 3
           isoform 2 [Homo sapiens]
          Length = 1259

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 30/117 (25%), Positives = 44/117 (37%), Gaps = 11/117 (9%)

Query: 136 LPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATKRQEA---- 191
           LP P K    P      + +K ++     PP     P  ++   G  EE  + +E     
Sbjct: 89  LPPPHKLRRLPPTSARHTRRKRKKEKTSAPPSEGTPPIQEEGGAGVDEEEEEEEEEEGES 148

Query: 192 ---PVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGTPVH 245
              PV+P P G PQ+   S      + +    LP R A     P + P  T  +P H
Sbjct: 149 EAEPVEPPPSGTPQKAKFSIGS---DEDDSPGLPGRAAVTKPLPSVGP-HTDKSPQH 201


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 35.4 bits (80), Expect = 0.18
 Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 9/115 (7%)

Query: 116  EEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHI--QRGPPHLQIRPP 173
            EEE+K RP      P+  P     ++A++  +       Q +Q  +  ++G P +     
Sbjct: 2093 EEERKRRP------PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD 2146

Query: 174  SQDLKDGTQEEATKRQEAPVDPRPEGDPQ-RTVISWRGAVIEPEQGTELPSRRAE 227
            + ++ +G  E+ T  +E+   P P  D + +T +  + A   P +  E PS + E
Sbjct: 2147 TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQME 2201


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 35.4 bits (80), Expect = 0.18
 Identities = 30/105 (28%), Positives = 48/105 (45%), Gaps = 5/105 (4%)

Query: 116 EEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQ 175
           +EE K  P+ A  K +   +    QKA+ + E  PE S QK   +  R  P  +     +
Sbjct: 133 KEETKSEPKEAEEKEST--LASEKQKAE-EKEAKPE-SGQKADAN-DRDKPEPKATVEEE 187

Query: 176 DLKDGTQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTE 220
           D K  +QEE  +R+E   +P+ +   +      + AV+E E   E
Sbjct: 188 DAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAE 232


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 35.0 bits (79), Expect = 0.24
 Identities = 25/99 (25%), Positives = 41/99 (41%), Gaps = 8/99 (8%)

Query: 107  HWKALAFRLEEEQKMRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPP 166
            H    A + + E + +P++ G + A     P PQ++ +         +   Q   Q+   
Sbjct: 3729 HSGPAALQSKAEPQAQPQLQGRQAA-----PGPQQSQSPSSRQIPSGAASRQPQTQQQQQ 3783

Query: 167  HLQIRPPSQDLKDGT---QEEATKRQEAPVDPRPEGDPQ 202
             L ++PP Q L       Q + T R  AP   +P G PQ
Sbjct: 3784 GLGLQPPQQALTQARLQQQSQPTTRGSAPAASQPAGKPQ 3822


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score = 35.0 bits (79), Expect = 0.24
 Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 5/50 (10%)

Query: 22  PPVGGAPWAVATTVVMYPPPPPPP-----HRDFISVTLSFGENYDNSKSW 66
           PP  G P    +     PPPPPPP     HRD I+   SF +++++  S+
Sbjct: 353 PPSRGKPPPPPSRTPAGPPPPPPPPLRNGHRDSITTVRSFLDDFESKYSF 402


>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
          Length = 674

 Score = 35.0 bits (79), Expect = 0.24
 Identities = 38/133 (28%), Positives = 55/133 (41%), Gaps = 26/133 (19%)

Query: 116 EEEQKMRPEIAGLKPANPPVLPAPQKADTDPENL-----------PEISSQKTQRHIQR- 163
           EE  +++ E  GL+P      P   K D   E L           P+++  +T    QR 
Sbjct: 194 EESLRVQHEETGLEP------PEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRE 247

Query: 164 GPPHLQIRPPSQDLKDGTQEEATKR-QEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELP 222
                +  PP Q   +  ++E  K  +EA ++P  E  P+      R A    E+GTELP
Sbjct: 248 STEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKAT--EEKGTELP 305

Query: 223 SRRAEVPTKPPLP 235
            R     TKP  P
Sbjct: 306 ER-----TKPDFP 313


>gi|119943102 CREB binding protein isoform b [Homo sapiens]
          Length = 2404

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 26/122 (21%), Positives = 44/122 (36%), Gaps = 10/122 (8%)

Query: 133  PPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQI-------RPPSQDLKDGTQEEA 185
            PP  P P      P   P ++  +    +  G P  Q+       +PP   ++   Q E 
Sbjct: 1867 PPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIER 1926

Query: 186  TKRQEA---PVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
              +Q+     V+      P RT +   G+ + P         +   P  P +PP + Q  
Sbjct: 1927 EAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQA 1986

Query: 243  PV 244
            P+
Sbjct: 1987 PL 1988



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 14/158 (8%)

Query: 96   CGLLFYINLADHWKA--LAFRLEEEQKMRPEIAGLKPANPP--VLPAPQKADTDPENLPE 151
            C + F +N+    +   +  RL++ Q MR  +A +   N P   LP+P  A         
Sbjct: 1800 CPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQP 1859

Query: 152  ISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEAT-----KRQEAPVDPRPEGDPQRTVI 206
             + Q  Q   Q  P  + + P        TQ   T        + P  P P   P   V 
Sbjct: 1860 STPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVE 1919

Query: 207  SWRGAVIEPEQGTELPSRRAEVPTKPPLPPART-QGTP 243
            + R    E +Q   L      V     +PP RT  GTP
Sbjct: 1920 AARQIEREAQQQQHL----YRVNINNSMPPGRTGMGTP 1953



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 25/108 (23%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 128 LKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATK 187
           L+   PP +  PQ A     + P  SS +T        P       +  ++   Q + T 
Sbjct: 831 LQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTP 890

Query: 188 RQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLP 235
           + + PV P     PQ +         +P  GT L    A +  + P P
Sbjct: 891 QPQTPVQPPSVATPQSSQQQPTPVHAQP-PGTPLSQAAASIDNRVPTP 937


>gi|119943104 CREB binding protein isoform a [Homo sapiens]
          Length = 2442

 Score = 34.7 bits (78), Expect = 0.31
 Identities = 26/122 (21%), Positives = 44/122 (36%), Gaps = 10/122 (8%)

Query: 133  PPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQI-------RPPSQDLKDGTQEEA 185
            PP  P P      P   P ++  +    +  G P  Q+       +PP   ++   Q E 
Sbjct: 1905 PPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIER 1964

Query: 186  TKRQEA---PVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQGT 242
              +Q+     V+      P RT +   G+ + P         +   P  P +PP + Q  
Sbjct: 1965 EAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQA 2024

Query: 243  PV 244
            P+
Sbjct: 2025 PL 2026



 Score = 33.5 bits (75), Expect = 0.69
 Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 14/158 (8%)

Query: 96   CGLLFYINLADHWKA--LAFRLEEEQKMRPEIAGLKPANPP--VLPAPQKADTDPENLPE 151
            C + F +N+    +   +  RL++ Q MR  +A +   N P   LP+P  A         
Sbjct: 1838 CPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQP 1897

Query: 152  ISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEAT-----KRQEAPVDPRPEGDPQRTVI 206
             + Q  Q   Q  P  + + P        TQ   T        + P  P P   P   V 
Sbjct: 1898 STPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVE 1957

Query: 207  SWRGAVIEPEQGTELPSRRAEVPTKPPLPPART-QGTP 243
            + R    E +Q   L      V     +PP RT  GTP
Sbjct: 1958 AARQIEREAQQQQHL----YRVNINNSMPPGRTGMGTP 1991



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 25/108 (23%), Positives = 39/108 (36%), Gaps = 1/108 (0%)

Query: 128 LKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDGTQEEATK 187
           L+   PP +  PQ A     + P  SS +T        P       +  ++   Q + T 
Sbjct: 869 LQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTP 928

Query: 188 RQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLP 235
           + + PV P     PQ +         +P  GT L    A +  + P P
Sbjct: 929 QPQTPVQPPSVATPQSSQQQPTPVHAQP-PGTPLSQAAASIDNRVPTP 975


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,991,952
Number of Sequences: 37866
Number of extensions: 1719124
Number of successful extensions: 10688
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 9985
Number of HSP's gapped (non-prelim): 870
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.