BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens] (247 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens] 496 e-141 gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens] 428 e-120 gi|5031763 hairy and enhancer of split 1 [Homo sapiens] 222 3e-58 gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens] 112 4e-25 gi|145207994 hairy and enhancer of split 7 [Homo sapiens] 96 2e-20 gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ... 92 3e-19 gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens] 89 4e-18 gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens] 89 5e-18 gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i... 87 1e-17 gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i... 85 7e-17 gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho... 84 1e-16 gi|66912172 hairy and enhancer of split 3 [Homo sapiens] 79 3e-15 gi|58219048 hairy and enhancer of split 5 [Homo sapiens] 78 6e-15 gi|13540521 basic helix-loop-helix domain containing, class B, 3... 63 3e-10 gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens] 61 8e-10 gi|71274142 HES/HEY-like transcription factor [Homo sapiens] 49 4e-06 gi|145309322 insulinoma-associated protein IA-6 [Homo sapiens] 42 5e-04 gi|119703742 vitelliform macular dystrophy 2-like 1 [Homo sapiens] 40 0.001 gi|45120115 hypothetical protein LOC56905 [Homo sapiens] 40 0.002 gi|91208437 GEM interacting protein [Homo sapiens] 40 0.002 gi|9945318 MAX binding protein [Homo sapiens] 39 0.003 gi|8924248 SRY-box 18 [Homo sapiens] 39 0.005 gi|29789008 Huntingtin interacting protein C isoform 2 [Homo sap... 39 0.005 gi|72534686 Huntingtin interacting protein C isoform 1 [Homo sap... 39 0.005 gi|192807323 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 gi|192807320 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 gi|192807318 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 gi|192807316 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 gi|192807314 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 gi|192807312 SWI/SNF-related matrix-associated actin-dependent r... 38 0.007 >gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens] Length = 247 Score = 496 bits (1278), Expect = e-141 Identities = 247/247 (100%), Positives = 247/247 (100%) Query: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD 60 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD Sbjct: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD 60 Query: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV Sbjct: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120 Query: 121 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 180 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR Sbjct: 121 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 180 Query: 181 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG 240 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG Sbjct: 181 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG 240 Query: 241 PWRPWLR 247 PWRPWLR Sbjct: 241 PWRPWLR 247 >gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens] Length = 221 Score = 428 bits (1100), Expect = e-120 Identities = 221/247 (89%), Positives = 221/247 (89%), Gaps = 26/247 (10%) Query: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD 60 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRK Sbjct: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRK------------------------ 36 Query: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120 SSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV Sbjct: 37 --SSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 94 Query: 121 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 180 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR Sbjct: 95 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 154 Query: 181 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG 240 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG Sbjct: 155 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGG 214 Query: 241 PWRPWLR 247 PWRPWLR Sbjct: 215 PWRPWLR 221 >gi|5031763 hairy and enhancer of split 1 [Homo sapiens] Length = 280 Score = 222 bits (565), Expect = 3e-58 Identities = 129/243 (53%), Positives = 151/243 (62%), Gaps = 43/243 (17%) Query: 1 MAADTPGKPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPD 60 M AD K S+SP+A PAS + TPDKP++A+EHRK Sbjct: 1 MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRK------------------------ 36 Query: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120 SSKP+MEKRRRARINESL+QLKTLILDAL+K+SSRHSKLEKADILEMTV+HLR+L+R Sbjct: 37 --SSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRA 94 Query: 121 QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSR 180 Q+TAALS DP+VLGKYRAGF EC+ EV RFL+ CEGV +VR+RLLGHLA C+ Q+ Sbjct: 95 QMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMT 154 Query: 181 RPASLSPAAPAEAPAPEVYAGRPLLPSLGGP--FPLLAPPLLPGLTRALPAAPRAGPQGP 238 P PA A P P P GGP P PP L +P A P Sbjct: 155 YPGQPHPALQAPPPPP---------PGPGGPQHAPFAPPPPL------VPIPGGAAPPPG 199 Query: 239 GGP 241 G P Sbjct: 200 GAP 202 >gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens] Length = 173 Score = 112 bits (279), Expect = 4e-25 Identities = 79/186 (42%), Positives = 99/186 (53%), Gaps = 29/186 (15%) Query: 62 QSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQ 121 +S KP++EKRRRARIN+SL+QLK LIL L +E+S SKLEKAD+LEMTVR L+ L Sbjct: 15 KSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQEL---P 71 Query: 122 VTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHL--AACLRQLGPS 179 ++ +A P YR G+ C+A + R L C + V +RLL HL A L Sbjct: 72 ASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGG 131 Query: 180 RRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPG 239 R S P+APA APA P P AP +P P +P GP Sbjct: 132 RAGDSSGPSAPAPAPA-------------SAPEPASAP--VPS-----PPSPPCGP---- 167 Query: 240 GPWRPW 245 G WRPW Sbjct: 168 GLWRPW 173 >gi|145207994 hairy and enhancer of split 7 [Homo sapiens] Length = 225 Score = 96.3 bits (238), Expect = 2e-20 Identities = 80/217 (36%), Positives = 104/217 (47%), Gaps = 37/217 (17%) Query: 61 PQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 120 P+ KP++EKRRR RIN SL +L+ L+L+ R ++ R+ KLEKA+ILE V +LR RV Sbjct: 13 PKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRV 72 Query: 121 Q----VTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQL 176 + + + A+ Y +GF ECL + F + PA R++L L LR Sbjct: 73 EPPGVPRSPVQDAEALASCYLSGFRECLLRLAAF--AHDASPA-ARAQLFSALHGYLRPK 129 Query: 177 GPSRRPA---------SLSPAAPAEAPA----PEVYAGRP-----LLPSL--------GG 210 P +P SL PAAPA PA P V+ G P PSL G Sbjct: 130 PPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLCSPRAGDSGA 189 Query: 211 PFPL--LAPPLLPGLTRALPAAPRAGPQGPGGPWRPW 245 P PL L PP P AP+A P WRPW Sbjct: 190 PAPLTGLLPP--PPPPHRQDGAPKAPLPPPPAFWRPW 224 >gi|7657154 hairy/enhancer-of-split related with YRPW motif-like [Homo sapiens] Length = 328 Score = 92.4 bits (228), Expect = 3e-19 Identities = 74/202 (36%), Positives = 103/202 (50%), Gaps = 28/202 (13%) Query: 49 GREGRGTQ---PVPDPQSS--------KPVMEKRRRARINESLAQLKTLILDALRKESSR 97 G+EG+ +Q P+ P SS + ++EKRRR RIN SL++L+ L+ A K+ S Sbjct: 21 GQEGQLSQMARPLSTPSSSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS- 79 Query: 98 HSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGV 157 SKLEKA++L+MTV HL+ L T A + GF ECL EV R+L EG Sbjct: 80 -SKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGP 138 Query: 158 PA---DVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEAPA--PEVYAGRPLLPSLGGPF 212 + VR RLL HL + ++ PS +P P PA + P LP+L Sbjct: 139 SSRADPVRIRLLSHLNSYAAEMEPSP-----TPTGPLAFPAWPWSFFHSCPGLPALSNQL 193 Query: 213 PLLA---PPLLPGLTRALPAAP 231 +L P+LPG++ PA P Sbjct: 194 AILGRVPSPVLPGVSS--PAYP 213 Score = 28.9 bits (63), Expect = 4.3 Identities = 27/86 (31%), Positives = 32/86 (37%), Gaps = 5/86 (5%) Query: 164 RLLGHLAACLRQLGPSRRPASLSPAAPAEAPA---PEVYAGRPLLPSLGGPFPLLAPPLL 220 R G + R + PSR +S A P E PA P + R S P + P Sbjct: 224 RATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTP 283 Query: 221 PGLT--RALPAAPRAGPQGPGGPWRP 244 PG T A A P PG RP Sbjct: 284 PGPTGSAAYVAVPTPNSSSPGPAGRP 309 >gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens] Length = 222 Score = 89.0 bits (219), Expect = 4e-18 Identities = 69/228 (30%), Positives = 102/228 (44%), Gaps = 35/228 (15%) Query: 41 PGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSK 100 PG R G + G + D ++ KP++EK+RRARINESL +L+ L+ A +K Sbjct: 7 PG-RDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA-------EAK 58 Query: 101 LEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD 160 LE A++LE+TVR ++ + R + ++ AG+ +C+ EV+ F++ C+ + A Sbjct: 59 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 118 Query: 161 VRSRLLGHLAACLRQLGPSRRPASLS----------PAAPAEAPAPEVYAGRPLLPSLGG 210 V + LL HL + P R +S P AP + P A +PS G Sbjct: 119 VAAELLNHLLESM----PLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPG 174 Query: 211 PFPLLAPPLLPGLTRALPAAPRAGP-------------QGPGGPWRPW 245 P L L L AP GP Q WRPW Sbjct: 175 PGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 222 >gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens] Length = 224 Score = 88.6 bits (218), Expect = 5e-18 Identities = 69/228 (30%), Positives = 102/228 (44%), Gaps = 33/228 (14%) Query: 41 PGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSK 100 PG R G + G + D ++ KP++EK+RRARINESL +L+ L+ A +K Sbjct: 7 PG-RDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGA-----EVQAK 60 Query: 101 LEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD 160 LE A++LE+TVR ++ + R + ++ AG+ +C+ EV+ F++ C+ + A Sbjct: 61 LENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT 120 Query: 161 VRSRLLGHLAACLRQLGPSRRPASLS----------PAAPAEAPAPEVYAGRPLLPSLGG 210 V + LL HL + P R +S P AP + P A +PS G Sbjct: 121 VAAELLNHLLESM----PLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPG 176 Query: 211 PFPLLAPPLLPGLTRALPAAPRAGP-------------QGPGGPWRPW 245 P L L L AP GP Q WRPW Sbjct: 177 PGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW 224 >gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 isoform a [Homo sapiens] Length = 304 Score = 87.4 bits (215), Expect = 1e-17 Identities = 74/193 (38%), Positives = 93/193 (48%), Gaps = 21/193 (10%) Query: 67 VMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAAL 126 ++EKRRR RIN SL++L+ L+ A K+ S +KLEKA+IL+MTV HL+ L Sbjct: 56 IIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHTAGGKGYF 113 Query: 127 SADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQLGPSRRPAS 184 A + GF ECLAEV R+L+ EG+ A +R RL+ H L R AS Sbjct: 114 DAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNYASQREAAS 169 Query: 185 LSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTRALPAAP-- 231 + A P V+ P LLP G G A P P L A P AP Sbjct: 170 GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPAL 229 Query: 232 RAGPQGPGGPWRP 244 RA P G GP P Sbjct: 230 RAPPSGSLGPVLP 242 >gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 isoform b [Homo sapiens] Length = 308 Score = 84.7 bits (208), Expect = 7e-17 Identities = 73/195 (37%), Positives = 92/195 (47%), Gaps = 21/195 (10%) Query: 67 VMEKRRRARINESLAQLKTLILDALRKESSRH--SKLEKADILEMTVRHLRSLRRVQVTA 124 ++EKRRR RIN SL++L+ L+ A K+ +KLEKA+IL+MTV HL+ L Sbjct: 56 IIEKRRRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKG 115 Query: 125 ALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQLGPSRRP 182 A + GF ECLAEV R+L+ EG+ A +R RL+ H L R Sbjct: 116 YFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNYASQREA 171 Query: 183 ASLSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTRALPAAP 231 AS + A P V+ P LLP G G A P P L A P AP Sbjct: 172 ASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAP 231 Query: 232 --RAGPQGPGGPWRP 244 RA P G GP P Sbjct: 232 ALRAPPSGSLGPVLP 246 >gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo sapiens] Length = 337 Score = 83.6 bits (205), Expect = 1e-16 Identities = 49/134 (36%), Positives = 76/134 (56%), Gaps = 4/134 (2%) Query: 55 TQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHL 114 T + + + ++EKRRR RIN SL++L+ L+ A K+ S +KLEKA+IL+MTV HL Sbjct: 43 TSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHL 100 Query: 115 RSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAAC 172 + L+ A + GF ECL EV R+L+ EG+ + +R RL+ HL+ C Sbjct: 101 KMLQATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTC 160 Query: 173 LRQLGPSRRPASLS 186 Q + +S++ Sbjct: 161 ATQREAAAMTSSMA 174 >gi|66912172 hairy and enhancer of split 3 [Homo sapiens] Length = 186 Score = 79.3 bits (194), Expect = 3e-15 Identities = 71/189 (37%), Positives = 95/189 (50%), Gaps = 22/189 (11%) Query: 68 MEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALS 127 MEK+RRARIN SL QLK+L L+ R KLEKADILE++V+++RSL+ + Sbjct: 1 MEKKRRARINVSLEQLKSL-LEKHYSHQIRKRKLEKADILELSVKYMRSLQ----NSLQG 55 Query: 128 ADPAVLG-KYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAA--CLRQLGPSRR-PA 183 P G + +GF CL V++ L + V + +R L+ AA + G + PA Sbjct: 56 LWPVPRGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAPA 115 Query: 184 SLSPAAPAE-APAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGP- 241 P PA APAP AG P P P LL P LPG + ++P A + P Sbjct: 116 LFRPCTPAVWAPAPA--AGGPRSP----PPLLLLPESLPGSSASVPPPQPASSRCAESPG 169 Query: 242 -----WRPW 245 WRPW Sbjct: 170 LGLRVWRPW 178 >gi|58219048 hairy and enhancer of split 5 [Homo sapiens] Length = 166 Score = 78.2 bits (191), Expect = 6e-15 Identities = 71/184 (38%), Positives = 88/184 (47%), Gaps = 41/184 (22%) Query: 65 KPVMEKRRRARINESLAQLKTLILDALRKESSRH---SKLEKADILEMTVRHLRSLRRVQ 121 KPV+EK RR RIN S+ QLK L L +E +RH SKLEKADILEM V + L+ + Sbjct: 21 KPVVEKMRRDRINSSIEQLKLL----LEQEFARHQPNSKLEKADILEMAVSY---LKHSK 73 Query: 122 VTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRR 181 A + ++ Y G+ CL E +FL +D + +LL H +R Sbjct: 74 AFVAAAGPKSLHQDYSEGYSWCLQEAVQFLT--LHAASDTQMKLLYHF----------QR 121 Query: 182 PASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGP 241 P PAAPA APA E A P APP P L+ AA A Q G Sbjct: 122 P----PAAPA-APAKEPKA------------PGAAPP--PALSAKATAAAAAAHQPACGL 162 Query: 242 WRPW 245 WRPW Sbjct: 163 WRPW 166 >gi|13540521 basic helix-loop-helix domain containing, class B, 3 [Homo sapiens] Length = 482 Score = 62.8 bits (151), Expect = 3e-10 Identities = 58/186 (31%), Positives = 93/186 (50%), Gaps = 24/186 (12%) Query: 67 VMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSL------RRV 120 ++EK+RR RINE +AQLK L+ + L+ + H LEKA +LE+T++HL++L + Sbjct: 51 LIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHLKALTALTEQQHQ 108 Query: 121 QVTAALSADPAV-------LGKYRAGFHECLAEVNRFLAGCEG-VPADVRS-RLLGHLAA 171 ++ A + + ++ L + +GF C EV ++L+ E P + R +L+ HL A Sbjct: 109 KIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHA 168 Query: 172 CLRQLGPSRRPASLSPAAPAE----APAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRAL 227 Q P+ P L+ P AP+ A P L G LA +P + R Sbjct: 169 VATQFLPT--PQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLA-YCVPVIQRTQ 225 Query: 228 PAAPRA 233 P+A A Sbjct: 226 PSAELA 231 >gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens] Length = 412 Score = 61.2 bits (147), Expect = 8e-10 Identities = 68/233 (29%), Positives = 110/233 (47%), Gaps = 50/233 (21%) Query: 9 PSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKP-- 66 PSA P PA + P EH G PG+ A + + + + + SK Sbjct: 5 PSAQP---PPACLPKAP-----GLEH---GDLPGMYPAHMYQVYKSRRGIKRSEDSKETY 53 Query: 67 -----VMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSL---- 117 ++EK+RR RINE +AQLK L+ + L+ + H LEKA +LE+T++H+++L Sbjct: 54 KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH--LEKAVVLELTLKHVKALTNLI 111 Query: 118 --RRVQVTAALSADPA--VLGK--------YRAGFHECLAEVNRFLAGCEGVPADVRSRL 165 ++ ++ A S A + G+ + +GF C EV ++LA E S+L Sbjct: 112 DQQQQKIIALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQL 171 Query: 166 LGHLAACLRQL---GPSRRPASLSPAAPAEAPAPEV--YAGRPLLPSLGGPFP 213 + HL + +L G SR+P+ PAP+V + +P P+ G P Sbjct: 172 VTHLHRVVSELLQGGTSRKPSD---------PAPKVMDFKEKPSSPAKGSEGP 215 >gi|71274142 HES/HEY-like transcription factor [Homo sapiens] Length = 327 Score = 48.9 bits (115), Expect = 4e-06 Identities = 66/251 (26%), Positives = 90/251 (35%), Gaps = 71/251 (28%) Query: 45 GATGGREGRGTQPVPDPQSSKPV----MEKRRRARINESLAQLKTLILDALRKESSRHS- 99 G G+ GT V + + PV +EKRRR RIN L +L + AL K+ Sbjct: 35 GPMAGKCPHGTLSVEESRVRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQGEPQEA 94 Query: 100 --------------------------------------KLEKADILEMTVRHLRSLR--- 118 KLEKA+ILEMTV++LR+L Sbjct: 95 LAQIRSRVRSLVLSSATVPDQQALGRCEGPFLLLQSSGKLEKAEILEMTVQYLRALHSAD 154 Query: 119 --RVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQL 176 R + A L A+ A + G+HEC+ + +L E + + + + A L+ Sbjct: 155 FPRGREKAELLAEFA--NYFHYGYHECMKNLVHYLTTVERM--ETKDTKYARILAFLQ-- 208 Query: 177 GPSRRPASLSPAAPAEAPAPE---VYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRA 233 S+ PA P PE Y P P G PG P A Sbjct: 209 --SKARLGAEPAFPPLGSLPEPDFSYQLHPAGPEFAGH--------SPGEAAVFPQGSGA 258 Query: 234 GPQGPGGPWRP 244 GP PW P Sbjct: 259 GP----FPWPP 265 >gi|145309322 insulinoma-associated protein IA-6 [Homo sapiens] Length = 566 Score = 42.0 bits (97), Expect = 5e-04 Identities = 29/88 (32%), Positives = 37/88 (42%), Gaps = 8/88 (9%) Query: 2 AADTPGKPSASPMA------GAPASASRTPDKP--RSAAEHRKVGSRPGVRGATGGREGR 53 +A PG A+P G A A+R R+A G R G GGREG Sbjct: 43 SASLPGAERATPPTREEPGKGLTAEAAREQSGSPCRAAGVSPGTGGREGAEWRAGGREGP 102 Query: 54 GTQPVPDPQSSKPVMEKRRRARINESLA 81 G P P P +KP + RRA + L+ Sbjct: 103 GPSPSPSPSPAKPAGAELRRAFLERCLS 130 >gi|119703742 vitelliform macular dystrophy 2-like 1 [Homo sapiens] Length = 509 Score = 40.4 bits (93), Expect = 0.001 Identities = 27/69 (39%), Positives = 29/69 (42%), Gaps = 8/69 (11%) Query: 183 ASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPP-------LLPGLTRALPAAPRAGP 235 AS S A E APE G PLL G P P PP L+PG GP Sbjct: 431 ASCSCAVVPEGAAPECSCGDPLLDP-GLPEPEAPPPAGPEPLTLIPGPVEPFSIVTMPGP 489 Query: 236 QGPGGPWRP 244 +GP PW P Sbjct: 490 RGPAPPWLP 498 >gi|45120115 hypothetical protein LOC56905 [Homo sapiens] Length = 1047 Score = 40.0 bits (92), Expect = 0.002 Identities = 58/229 (25%), Positives = 91/229 (39%), Gaps = 44/229 (19%) Query: 18 PASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDPQSSKPVMEKRRRARIN 77 P SA+ PD + +E G G RG +EG P SKP+ R + Sbjct: 527 PDSATAEPDSAPATSE----GQDKGCRGTLPAQEG--------PSGSKPL-----RGSLK 569 Query: 78 ESLAQLKTLILD-ALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSADPAVLGKY 136 E +A LD ++RK ++ S ++ + RS+ + TAA+ D +G Sbjct: 570 EEVA------LDLSVRKPTAEASPVKAS----------RSVEHAKPTAAM--DVPDVGNM 611 Query: 137 RAGFHECLAEVNRFLAGCEGVPADV----RSRLLGHLAACLRQ---LGPSRRPASLSPAA 189 + L +++ G GVP R+ +A R+ L P+ PA++ P+ Sbjct: 612 VSDLPG-LKKIDTEAPGLPGVPVTTDAMPRTNFHSSVAFMFRKFKILRPAPLPAAVVPST 670 Query: 190 PAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGP 238 P APAP A P +G P + + ALP+ P P Sbjct: 671 PTSAPAPTQPAPTPTSGPIGLRILAQQPLSVTCFSLALPSPPAVAVASP 719 Score = 29.6 bits (65), Expect = 2.5 Identities = 31/98 (31%), Positives = 39/98 (39%), Gaps = 15/98 (15%) Query: 15 AGAPASASRTP--DKPRSAA--------EHRKVGSRPGVRG-----ATGGREGRGTQPVP 59 AGA +S+ T D+P S A + RK G +P G A G E G P P Sbjct: 932 AGAVSSSEPTVARDEPESLALAQKSPAPKVRKPGRKPPTPGPEKAEAAAGEESCGASPTP 991 Query: 60 DPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSR 97 +S P + R R A L L L +SSR Sbjct: 992 ATSASPPGPTLKARFRSLLETAWLNGLALPTWGHKSSR 1029 >gi|91208437 GEM interacting protein [Homo sapiens] Length = 970 Score = 39.7 bits (91), Expect = 0.002 Identities = 58/209 (27%), Positives = 77/209 (36%), Gaps = 44/209 (21%) Query: 48 GGREGRGTQPVPDPQSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADI- 106 G E Q P P + E+RRR+R AQ K +AL + R + + D+ Sbjct: 233 GSPEDSAPQASPGPSKQQ---ERRRRSREE---AQAKAQEAEALYQACVREANARQQDLE 286 Query: 107 --LEMTVRHLRSLRRVQVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPADVRSR 164 + V H+R L D E L V L G G A+ R Sbjct: 287 IAKQRIVSHVRKL-------VFQGD------------EVLRRVTLSLFGLRGAQAERGPR 327 Query: 165 LLGHLAACLRQLGPSRR----PASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPL-----L 215 LA C P +R +L P AP P P ++ + LPSL PL L Sbjct: 328 AFAALAECCAPFEPGQRYQEFVRALRPEAP--PPPPPAFSFQEFLPSLNSS-PLDIRKKL 384 Query: 216 APPLLPGLTRALPAAPRAGP-QGPGGPWR 243 + PL P L + GP + PG WR Sbjct: 385 SGPLPPRLDE---NSAEPGPWEDPGTGWR 410 >gi|9945318 MAX binding protein [Homo sapiens] Length = 582 Score = 39.3 bits (90), Expect = 0.003 Identities = 24/56 (42%), Positives = 28/56 (50%), Gaps = 5/56 (8%) Query: 182 PASLSPAAPAEAPAPEVYAGRPL----LPSL-GGPFPLLAPPLLPGLTRALPAAPR 232 P LSP AP AP P + PL +P + P PL PP LP + LP APR Sbjct: 64 PLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPR 119 Score = 30.4 bits (67), Expect = 1.5 Identities = 31/118 (26%), Positives = 49/118 (41%), Gaps = 22/118 (18%) Query: 3 ADTPG-KPSASPMAGAPASASRTPDKPRSAAEHRKVGSRPGVRGATGGREGRGTQPVPDP 61 A PG +P +P P + P + + RPG G GT+ V + Sbjct: 177 APHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPG---------GIGTREVHNK 227 Query: 62 QSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRR 119 +EK RRA + E LK I + K++S S +L +R+++SL+R Sbjct: 228 ------LEKNRRAHLKECFETLKRNIPNVDDKKTSNLS------VLRTALRYIQSLKR 273 Score = 28.5 bits (62), Expect = 5.6 Identities = 20/65 (30%), Positives = 25/65 (38%), Gaps = 5/65 (7%) Query: 180 RRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPG 239 + PA L PAP + + +P G P PL P T L AP G Q Sbjct: 132 KEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLP-----TPVLTIAPHPGVQPQL 186 Query: 240 GPWRP 244 P +P Sbjct: 187 APQQP 191 >gi|8924248 SRY-box 18 [Homo sapiens] Length = 384 Score = 38.5 bits (88), Expect = 0.005 Identities = 73/270 (27%), Positives = 96/270 (35%), Gaps = 54/270 (20%) Query: 2 AADTPGKPSASPMAGAPASASRTPDKPRS---AAEHRKVGSRPGVRGATGGREGRGTQPV 58 AADT G + APA+ + P RS + E + G P RG R+ + Sbjct: 29 AADTRGLAAGPAALAAPAAPASPPSPQRSPPRSPEPGRYGLSPAGRGE---RQAADESRI 85 Query: 59 PDPQSSKPVMEKRRRARINESLAQLKTLILD-ALRKESSRHSKLEKADILE----MTVRH 113 P ++ V K R R+ + L +L L K + EK +E + V+H Sbjct: 86 RRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQH 145 Query: 114 LRS--------LRRVQVTAALSADPAVL------------------GKYRAGFHECLAEV 147 LR R+ Q A +P +L G RA F E L + Sbjct: 146 LRDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQPPPEPFPAASGSARA-FRE-LPPL 203 Query: 148 NRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAEA---PAPEVYAGRPL 204 G G+P RS L G L P PAAP + P YA L Sbjct: 204 GAEFDGL-GLPTPERSPLDG--------LEPGEAAFFPPPAAPEDCALRPFRAPYAPTEL 254 Query: 205 LPSLGGPFPLLAPPLLPGLTRALPAAPRAG 234 GG + PL L A PAAP AG Sbjct: 255 SRDPGGCY---GAPLAEALRTAPPAAPLAG 281 >gi|29789008 Huntingtin interacting protein C isoform 2 [Homo sapiens] Length = 858 Score = 38.5 bits (88), Expect = 0.005 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 15/66 (22%) Query: 179 SRRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPL-----LAPPLLPGLTRALPAAPRA 233 S+RP ++ P P P P+LP +G P PL + PP++PG+ +PA P Sbjct: 19 SQRPPAIPPMPPGILP--------PMLPPMGAPPPLTQIPGMVPPMMPGM--LMPAVPVT 68 Query: 234 GPQGPG 239 PG Sbjct: 69 AATAPG 74 >gi|72534686 Huntingtin interacting protein C isoform 1 [Homo sapiens] Length = 871 Score = 38.5 bits (88), Expect = 0.005 Identities = 22/66 (33%), Positives = 32/66 (48%), Gaps = 15/66 (22%) Query: 179 SRRPASLSPAAPAEAPAPEVYAGRPLLPSLGGPFPL-----LAPPLLPGLTRALPAAPRA 233 S+RP ++ P P P P+LP +G P PL + PP++PG+ +PA P Sbjct: 25 SQRPPAIPPMPPGILP--------PMLPPMGAPPPLTQIPGMVPPMMPGM--LMPAVPVT 74 Query: 234 GPQGPG 239 PG Sbjct: 75 AATAPG 80 >gi|192807323 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform A [Homo sapiens] Length = 1679 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 >gi|192807320 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform F [Homo sapiens] Length = 1613 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 >gi|192807318 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform E [Homo sapiens] Length = 1614 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 >gi|192807316 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform D [Homo sapiens] Length = 1616 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 >gi|192807314 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform C [Homo sapiens] Length = 1617 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 >gi|192807312 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 isoform B [Homo sapiens] Length = 1647 Score = 38.1 bits (87), Expect = 0.007 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 22/134 (16%) Query: 128 ADPAVLGKYRAG--------FHECLAEVNRF--LAGCEGVPADVRSRLLGHLAAC-LRQL 176 ADP LG+ G H+ A++ + LA + +P ++ + G ++Q Sbjct: 157 ADPQALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQ 216 Query: 177 GPSRRPASLSPAAPAEAPAPEVYAGR-PLLPSLGGPF----PLLAPPLLPGLTRALPAAP 231 P+ P S+S P P P G P P+ P P + PP G+ +P P Sbjct: 217 MPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP 276 Query: 232 RAGPQGPGGPWRPW 245 PGGP +PW Sbjct: 277 ------PGGPPKPW 284 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.134 0.404 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,012,403 Number of Sequences: 37866 Number of extensions: 733739 Number of successful extensions: 8335 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 140 Number of HSP's successfully gapped in prelim test: 570 Number of HSP's that attempted gapping in prelim test: 6538 Number of HSP's gapped (non-prelim): 2343 length of query: 247 length of database: 18,247,518 effective HSP length: 100 effective length of query: 147 effective length of database: 14,460,918 effective search space: 2125754946 effective search space used: 2125754946 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.