Search of human proteins with 21361581

Search of human proteins with 21361581

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361581 solute carrier family 6 (neurotransmitter
transporter, GABA), member 13 [Homo sapiens]
         (602 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361581 solute carrier family 6 (neurotransmitter transporte...  1261   0.0  
gi|171184408 solute carrier family 6 (neurotransmitter transport...   887   0.0  
gi|171184406 solute carrier family 6 (neurotransmitter transport...   887   0.0  
gi|171184404 solute carrier family 6 (neurotransmitter transport...   887   0.0  
gi|7657587 solute carrier family 6 (neurotransmitter transporter...   882   0.0  
gi|197276623 solute carrier family 6 (neurotransmitter transport...   771   0.0  
gi|54607094 solute carrier family 6 (neurotransmitter transporte...   771   0.0  
gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo sapi...   676   0.0  
gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo sa...   657   0.0  
gi|188528618 solute carrier family 6 (neurotransmitter transport...   638   0.0  
gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo sa...   590   e-168
gi|134304856 solute carrier family 6, member 7 [Homo sapiens]         530   e-150
gi|92859670 solute carrier family 6 (neurotransmitter transporte...   528   e-150
gi|4557046 solute carrier family 6 member 2 [Homo sapiens]            514   e-145
gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo sap...   514   e-145
gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo sap...   514   e-145
gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo sap...   514   e-145
gi|4507041 solute carrier family 6 (neurotransmitter transporter...   507   e-143
gi|4507043 solute carrier family 6 member 4 [Homo sapiens]            503   e-142
gi|6005715 solute carrier family 6 (amino acid transporter), mem...   471   e-133
gi|51468073 solute carrier family 6, member 19 [Homo sapiens]         366   e-101
gi|194018524 solute carrier family 6, member 18 [Homo sapiens]        362   e-100
gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo s...   340   2e-93
gi|58219014 solute carrier family 6, member 17 [Homo sapiens]         283   3e-76
gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo s...   281   1e-75
gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo s...   268   8e-72
gi|197276625 solute carrier family 6 (neurotransmitter transport...   232   6e-61
gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo ...   198   1e-50
gi|55749589 solute carrier family 6, member 16 [Homo sapiens]         188   1e-47
gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo s...   180   3e-45

>gi|21361581 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 13 [Homo sapiens]
          Length = 602

 Score = 1261 bits (3264), Expect = 0.0
 Identities = 602/602 (100%), Positives = 602/602 (100%)

Query: 1   MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY 60
           MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY
Sbjct: 1   MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY 60

Query: 61  LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM 120
           LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM
Sbjct: 61  LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM 120

Query: 121 IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT 180
           IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT
Sbjct: 121 IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT 180

Query: 181 SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF 240
           SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF
Sbjct: 181 SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF 240

Query: 241 PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL 300
           PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL
Sbjct: 241 PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL 300

Query: 301 GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI 360
           GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
Sbjct: 301 GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI 360

Query: 361 AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI 420
           AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI
Sbjct: 361 AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI 420

Query: 421 LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI 480
           LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI
Sbjct: 421 LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI 480

Query: 481 EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS 540
           EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
Sbjct: 481 EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS 540

Query: 541 SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES 600
           SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES
Sbjct: 541 SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES 600

Query: 601 HC 602
           HC
Sbjct: 601 HC 602


>gi|171184408 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  887 bits (2292), Expect = 0.0
 Identities = 421/589 (71%), Positives = 486/589 (82%), Gaps = 8/589 (1%)

Query: 21  MEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFT 80
           +++++ED   +RG W NKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY +F F 
Sbjct: 25  LDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 81  CGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYL 140
           CGIPVF LE ALGQYTSQG VTAWRKICP+F+GIG AS +I   LNVYYII+LAWALFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 141 FSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTS-ENATSPVIEFWERRVLKISDGIQ 199
           FSSFT +LPW  C + WNTEHC +F   +G+   T  EN TSPV+EFWERRVL I+ GI 
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH 204

Query: 200 HLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAA 259
            LG+LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV+LLIRGVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 260 QGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCF 319
           QGI +YL P+L RL DPQVWMDAGTQIFFSFAIC GCLTALGSYNKYHNNCY+DCIALCF
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 320 LNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCF 379
           LNS TSFVAGF +FSILGFMSQEQGVPISEVAESGPGLAFIA+P+AV M+P S LW+C F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 380 FFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGG 439
           F M++ LGLDSQFVCVE LVTA +DM+P   RK  RRE+LIL ++V+ +L+GL ++TEGG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 440 MYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFL 499
           MY+FQLFDYYA+SG+CLLF+++FE +C++WVYGA RFYDNIEDMIGYRPWPL+K  WLFL
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 500 TPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGP 559
           TP +C ATFLFSL KYTPL YN  Y YP WG ++GW LALSSMVC+P + +  L   +GP
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 560 FRERIRQLMCPAEDLPQ--RNP-----AGPSAPATPRTSLLRLTELESH 601
           FR+R+RQL+ P   LPQ  ++P     AG +   +P    L   E E+H
Sbjct: 565 FRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETH 613


>gi|171184406 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  887 bits (2292), Expect = 0.0
 Identities = 421/589 (71%), Positives = 486/589 (82%), Gaps = 8/589 (1%)

Query: 21  MEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFT 80
           +++++ED   +RG W NKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY +F F 
Sbjct: 25  LDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 81  CGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYL 140
           CGIPVF LE ALGQYTSQG VTAWRKICP+F+GIG AS +I   LNVYYII+LAWALFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 141 FSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTS-ENATSPVIEFWERRVLKISDGIQ 199
           FSSFT +LPW  C + WNTEHC +F   +G+   T  EN TSPV+EFWERRVL I+ GI 
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH 204

Query: 200 HLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAA 259
            LG+LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV+LLIRGVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 260 QGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCF 319
           QGI +YL P+L RL DPQVWMDAGTQIFFSFAIC GCLTALGSYNKYHNNCY+DCIALCF
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 320 LNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCF 379
           LNS TSFVAGF +FSILGFMSQEQGVPISEVAESGPGLAFIA+P+AV M+P S LW+C F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 380 FFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGG 439
           F M++ LGLDSQFVCVE LVTA +DM+P   RK  RRE+LIL ++V+ +L+GL ++TEGG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 440 MYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFL 499
           MY+FQLFDYYA+SG+CLLF+++FE +C++WVYGA RFYDNIEDMIGYRPWPL+K  WLFL
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 500 TPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGP 559
           TP +C ATFLFSL KYTPL YN  Y YP WG ++GW LALSSMVC+P + +  L   +GP
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 560 FRERIRQLMCPAEDLPQ--RNP-----AGPSAPATPRTSLLRLTELESH 601
           FR+R+RQL+ P   LPQ  ++P     AG +   +P    L   E E+H
Sbjct: 565 FRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETH 613


>gi|171184404 solute carrier family 6 (neurotransmitter transporter,
           betaine/GABA), member 12 [Homo sapiens]
          Length = 614

 Score =  887 bits (2292), Expect = 0.0
 Identities = 421/589 (71%), Positives = 486/589 (82%), Gaps = 8/589 (1%)

Query: 21  MEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFT 80
           +++++ED   +RG W NKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPY +F F 
Sbjct: 25  LDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFV 84

Query: 81  CGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYL 140
           CGIPVF LE ALGQYTSQG VTAWRKICP+F+GIG AS +I   LNVYYII+LAWALFYL
Sbjct: 85  CGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYL 144

Query: 141 FSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTS-ENATSPVIEFWERRVLKISDGIQ 199
           FSSFT +LPW  C + WNTEHC +F   +G+   T  EN TSPV+EFWERRVL I+ GI 
Sbjct: 145 FSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIH 204

Query: 200 HLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAA 259
            LG+LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV+LLIRGVTLPGA 
Sbjct: 205 DLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAY 264

Query: 260 QGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCF 319
           QGI +YL P+L RL DPQVWMDAGTQIFFSFAIC GCLTALGSYNKYHNNCY+DCIALCF
Sbjct: 265 QGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCF 324

Query: 320 LNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCF 379
           LNS TSFVAGF +FSILGFMSQEQGVPISEVAESGPGLAFIA+P+AV M+P S LW+C F
Sbjct: 325 LNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLF 384

Query: 380 FFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGG 439
           F M++ LGLDSQFVCVE LVTA +DM+P   RK  RRE+LIL ++V+ +L+GL ++TEGG
Sbjct: 385 FIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGG 444

Query: 440 MYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFL 499
           MY+FQLFDYYA+SG+CLLF+++FE +C++WVYGA RFYDNIEDMIGYRPWPL+K  WLFL
Sbjct: 445 MYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFL 504

Query: 500 TPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGP 559
           TP +C ATFLFSL KYTPL YN  Y YP WG ++GW LALSSMVC+P + +  L   +GP
Sbjct: 505 TPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGP 564

Query: 560 FRERIRQLMCPAEDLPQ--RNP-----AGPSAPATPRTSLLRLTELESH 601
           FR+R+RQL+ P   LPQ  ++P     AG +   +P    L   E E+H
Sbjct: 565 FRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETH 613


>gi|7657587 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 11 [Homo sapiens]
          Length = 632

 Score =  882 bits (2278), Expect = 0.0
 Identities = 410/579 (70%), Positives = 480/579 (82%), Gaps = 4/579 (0%)

Query: 7   GTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNG 66
           G +S G     +P +  K +    ERGHWNNK+EFVLSVAGEIIGLGNVWRFPYLCYKNG
Sbjct: 27  GCSSGGAAPARHPRV--KRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNG 84

Query: 67  GGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLN 126
           GGAF IPY+VF   CGIPVF LETALGQ+TS+GG+T WRK+CP+FEGIGYA+Q+I   LN
Sbjct: 85  GGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLN 144

Query: 127 VYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGS--LNGTSENATSPVI 184
           VYYII+LAWA+FYL + FT +LPW  C HEWNTE+C+EFQK N S   + + +NATSPV+
Sbjct: 145 VYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVM 204

Query: 185 EFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLM 244
           EFWE RVL ISDGI+H+G LRWELALCLL AW ICYFCIWKG KSTGKVVY TATFPY+M
Sbjct: 205 EFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIM 264

Query: 245 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYN 304
           L++LLIRGVTLPGA++GI+FYLYP+L+RL DPQVW+DAGTQIFFS+AICLGCLTALGSYN
Sbjct: 265 LLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYN 324

Query: 305 KYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPR 364
            Y+NNCYRDCI LC LNSGTSFVAGFAIFS+LGFM+ EQGVPI+EVAESGPGLAFIAYP+
Sbjct: 325 NYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPK 384

Query: 365 AVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVS 424
           AV M+P SPLWA  FF M++ LGLDSQFVCVESLVTA+VDMYP VFR+  RRE+LIL +S
Sbjct: 385 AVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALS 444

Query: 425 VVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 484
           V+S+ +GL+MLTEGGMY+FQLFD YAASGMCLLFVAIFE +C+ WVYG+ RFYDNIEDMI
Sbjct: 445 VISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMI 504

Query: 485 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVC 544
           GYRP  LIK+CW+ +TP +C   F+F LIKY PL YN  YTYP WG  +GWL+ALSSM+C
Sbjct: 505 GYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLC 564

Query: 545 IPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPS 583
           IP W    +   +G   E++++L  P+ DL  R   G S
Sbjct: 565 IPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVS 603


>gi|197276623 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  771 bits (1992), Expect = 0.0
 Identities = 360/554 (64%), Positives = 434/554 (78%), Gaps = 3/554 (0%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E + E    +R  W++K++FVLSVAG  +GLGNVWRFPYLCYKNGGGAF IPY +FLF  
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           G+PVF LE  +GQYTS+GG+T W KICP+F GIGYAS +IV LLNVYYI++LAWA +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 142 SSFTIDLPWGGCYHEWNTEHCME-FQKTNGS--LNGTSENATSPVIEFWERRVLKISDGI 198
            SF  +LPW  C H WNT HCME   + N S  +  +S N TSPVIEFWER VL +S GI
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGI 210

Query: 199 QHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGA 258
            H G+L+W+LALCLLL W++C+FCIWKGV+STGKVVYFTATFP+ ML+VLL+RG+TLPGA
Sbjct: 211 DHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGA 270

Query: 259 AQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALC 318
             GI+FYLYP++TRL DPQVW+DAGTQIFFS+AICLG +T+LGSYNKY  N YRDC+ L 
Sbjct: 271 GAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLG 330

Query: 319 FLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACC 378
            LNSGTSFV+GFAIFSILGFM+QEQGV I++VAESGPGLAFIAYP+AV M+P    W+  
Sbjct: 331 CLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSIL 390

Query: 379 FFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEG 438
           FF M++LLGLDSQFV VE  +T+LVD+YP   RK  RRE+ I  V  +S+L+GL M+TEG
Sbjct: 391 FFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEG 450

Query: 439 GMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLF 498
           GMYVFQLFDYYAASG+CLL+VA FE   +AW+YG    YD IEDMIGYRP P +KY W  
Sbjct: 451 GMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAV 510

Query: 499 LTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKG 558
           +TP +C   F+FSL+KY PLTYNK Y YP W   LGW LALSSM+C+P   + RL   +G
Sbjct: 511 ITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEG 570

Query: 559 PFRERIRQLMCPAE 572
           PF  R++ L+ P E
Sbjct: 571 PFLVRVKYLLTPRE 584


>gi|54607094 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform a [Homo sapiens]
          Length = 620

 Score =  771 bits (1992), Expect = 0.0
 Identities = 360/554 (64%), Positives = 434/554 (78%), Gaps = 3/554 (0%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E + E    +R  W++K++FVLSVAG  +GLGNVWRFPYLCYKNGGGAF IPY +FLF  
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           G+PVF LE  +GQYTS+GG+T W KICP+F GIGYAS +IV LLNVYYI++LAWA +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 142 SSFTIDLPWGGCYHEWNTEHCME-FQKTNGS--LNGTSENATSPVIEFWERRVLKISDGI 198
            SF  +LPW  C H WNT HCME   + N S  +  +S N TSPVIEFWER VL +S GI
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGI 210

Query: 199 QHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGA 258
            H G+L+W+LALCLLL W++C+FCIWKGV+STGKVVYFTATFP+ ML+VLL+RG+TLPGA
Sbjct: 211 DHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGA 270

Query: 259 AQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALC 318
             GI+FYLYP++TRL DPQVW+DAGTQIFFS+AICLG +T+LGSYNKY  N YRDC+ L 
Sbjct: 271 GAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLG 330

Query: 319 FLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACC 378
            LNSGTSFV+GFAIFSILGFM+QEQGV I++VAESGPGLAFIAYP+AV M+P    W+  
Sbjct: 331 CLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSIL 390

Query: 379 FFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEG 438
           FF M++LLGLDSQFV VE  +T+LVD+YP   RK  RRE+ I  V  +S+L+GL M+TEG
Sbjct: 391 FFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEG 450

Query: 439 GMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLF 498
           GMYVFQLFDYYAASG+CLL+VA FE   +AW+YG    YD IEDMIGYRP P +KY W  
Sbjct: 451 GMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAV 510

Query: 499 LTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKG 558
           +TP +C   F+FSL+KY PLTYNK Y YP W   LGW LALSSM+C+P   + RL   +G
Sbjct: 511 ITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEG 570

Query: 559 PFRERIRQLMCPAE 572
           PF  R++ L+ P E
Sbjct: 571 PFLVRVKYLLTPRE 584


>gi|5032097 solute carrier family 6 member 8 isoform 1 [Homo
           sapiens]
          Length = 635

 Score =  676 bits (1743), Expect = 0.0
 Identities = 320/574 (55%), Positives = 403/574 (70%), Gaps = 9/574 (1%)

Query: 32  RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETA 91
           R  W  +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY++     GIP+F LE +
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 92  LGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWG 151
           LGQ+   G +  W  ICP+F+G+GYAS +IV   N YYI+VLAW  +YL  SFT  LPW 
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 152 GCYHEWNTEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGA 203
            C H WNT  C+E  +     N +  N T        SPVIEFWE +VL++S G++  GA
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 204 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQ 263
           L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA  GI 
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 264 FYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 323
           +YL P+ ++L  PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY+D I L  +NSG
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSG 350

Query: 324 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMV 383
           TSF AGF +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA  FFFM+
Sbjct: 351 TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFML 410

Query: 384 VLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVF 443
           +LLGLDSQFV VE  +T L+D+ P  +  + +RE+ +     + F++ L M+T+GGMYVF
Sbjct: 411 LLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVF 470

Query: 444 QLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAV 503
           QLFDYY+ASG  LL+ A +E + VAWVYGA RF D+I  MIGYRP P +K+CW F TP V
Sbjct: 471 QLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLV 530

Query: 504 CTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 563
           C   F+F+++ Y PL YN  Y YPWWG+A+GW  ALSSM+C+P   L  L   KG   ER
Sbjct: 531 CMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 590

Query: 564 IRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTE 597
            + L  P   L         A     T+L  ++E
Sbjct: 591 WQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSE 624


>gi|218563756 solute carrier family 6 member 8 isoform 2 [Homo
           sapiens]
          Length = 625

 Score =  657 bits (1696), Expect = 0.0
 Identities = 315/574 (54%), Positives = 397/574 (69%), Gaps = 19/574 (3%)

Query: 32  RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETA 91
           R  W  +M+F++S  G  +GLGNVWRFPYLCYKNGGG F IPY++     GIP+F LE +
Sbjct: 52  RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEIS 111

Query: 92  LGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWG 151
           LGQ+   G +  W  ICP+F+G+GYAS +IV   N YYI+VLAW  +YL  SFT  LPW 
Sbjct: 112 LGQFMKAGSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWA 170

Query: 152 GCYHEWNTEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGA 203
            C H WNT  C+E  +     N +  N T        SPVIEFWE +VL++S G++  GA
Sbjct: 171 TCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGA 230

Query: 204 LRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQ 263
           L WE+ LCLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA  GI 
Sbjct: 231 LNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGII 290

Query: 264 FYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSG 323
           +YL P+ ++L  PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY          +G
Sbjct: 291 YYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCY----------NG 340

Query: 324 TSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMV 383
           TSF AGF +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA  FFFM+
Sbjct: 341 TSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFML 400

Query: 384 VLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVF 443
           +LLGLDSQFV VE  +T L+D+ P  +  + +RE+ +     + F++ L M+T+GGMYVF
Sbjct: 401 LLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVF 460

Query: 444 QLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAV 503
           QLFDYY+ASG  LL+ A +E + VAWVYGA RF D+I  MIGYRP P +K+CW F TP V
Sbjct: 461 QLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLV 520

Query: 504 CTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRER 563
           C   F+F+++ Y PL YN  Y YPWWG+A+GW  ALSSM+C+P   L  L   KG   ER
Sbjct: 521 CMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAER 580

Query: 564 IRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTE 597
            + L  P   L         A     T+L  ++E
Sbjct: 581 WQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSE 614


>gi|188528618 solute carrier family 6 (neurotransmitter transporter,
           GABA), member 1 [Homo sapiens]
          Length = 599

 Score =  638 bits (1646), Expect = 0.0
 Identities = 302/577 (52%), Positives = 408/577 (70%), Gaps = 12/577 (2%)

Query: 10  SNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGA 69
           +N + K +   ++KK  D   +R  W  + +F++S  G  IGLGNVWRFPYLC KNGGGA
Sbjct: 23  ANDKPKTLVVKVQKKAAD-LPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGA 81

Query: 70  FFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYY 129
           F IPY + L   G+P+FLLE +LGQYTS GG+  W K+ P+F+G+G A+ ++   LN+YY
Sbjct: 82  FLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIYY 140

Query: 130 IIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWER 189
           I++++WA++YL++SFT  LPW  C + WNT+ C     +N S+  T+ N TS V+EFWER
Sbjct: 141 IVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCF----SNYSMVNTT-NMTSAVVEFWER 195

Query: 190 RVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLL 249
            + +++DG+   G +RW LA+ L +AW++ YFCIWKGV  TGKVVYF+AT+PY+ML++L 
Sbjct: 196 NMHQMTDGLDKPGQIRWPLAITLAIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILF 255

Query: 250 IRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNN 309
            RGVTLPGA +GI FY+ PN  +L D +VW+DA TQIFFS+ + LG L ALGSYN +HNN
Sbjct: 256 FRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNN 315

Query: 310 CYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVML 369
            YRD I +C +NS TS  AGF IFSI+GFM+      I++VA SGPGLAF+AYP AV  L
Sbjct: 316 VYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQL 375

Query: 370 PFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFL 429
           P SPLWA  FF M+++LG+DSQF  VE  +TALVD YP + R  NRRE+ I  V ++S+L
Sbjct: 376 PISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLR--NRRELFIAAVCIISYL 433

Query: 430 VGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPW 489
           +GL  +T+GG+YVF+LFDYY+ASGM LLF+  FE + ++W YG  RFYDNI++M+G RP 
Sbjct: 434 IGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPC 493

Query: 490 PLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWS 549
              K CW F TP +    F+FS ++ TPLT    Y +P WG  +GWL+ALSSMV IP + 
Sbjct: 494 IWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMG-NYVFPKWGQGVGWLMALSSMVLIPGYM 552

Query: 550 LYRLGTLKGPFRERIRQLMCPAEDL--PQRNPAGPSA 584
            Y   TLKG  ++RI+ ++ P+ED+  P+  P  P A
Sbjct: 553 AYMFLTLKGSLKQRIQVMVQPSEDIVRPENGPEQPQA 589


>gi|218563758 solute carrier family 6 member 8 isoform 3 [Homo
           sapiens]
          Length = 520

 Score =  590 bits (1520), Expect = e-168
 Identities = 283/507 (55%), Positives = 356/507 (70%), Gaps = 9/507 (1%)

Query: 99  GGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWN 158
           G +  W  ICP+F+G+GYAS +IV   N YYI+VLAW  +YL  SFT  LPW  C H WN
Sbjct: 4   GSINVWN-ICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWN 62

Query: 159 TEHCMEFQKTNGSLNGTSENAT--------SPVIEFWERRVLKISDGIQHLGALRWELAL 210
           T  C+E  +     N +  N T        SPVIEFWE +VL++S G++  GAL WE+ L
Sbjct: 63  TPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTL 122

Query: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270
           CLL  WV+ YFC+WKGVKSTGK+VYFTATFPY++LVVLL+RGV LPGA  GI +YL P+ 
Sbjct: 123 CLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDW 182

Query: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330
           ++L  PQVW+DAGTQIFFS+AI LG LTALGSYN+++NNCY+D I L  +NSGTSF AGF
Sbjct: 183 SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGF 242

Query: 331 AIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDS 390
            +FSILGFM+ EQGV IS+VAESGPGLAFIAYPRAV ++P +PLWA  FFFM++LLGLDS
Sbjct: 243 VVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDS 302

Query: 391 QFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYA 450
           QFV VE  +T L+D+ P  +  + +RE+ +     + F++ L M+T+GGMYVFQLFDYY+
Sbjct: 303 QFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYS 362

Query: 451 ASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLF 510
           ASG  LL+ A +E + VAWVYGA RF D+I  MIGYRP P +K+CW F TP VC   F+F
Sbjct: 363 ASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIF 422

Query: 511 SLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCP 570
           +++ Y PL YN  Y YPWWG+A+GW  ALSSM+C+P   L  L   KG   ER + L  P
Sbjct: 423 NVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQP 482

Query: 571 AEDLPQRNPAGPSAPATPRTSLLRLTE 597
              L         A     T+L  ++E
Sbjct: 483 IWGLHHLEYRAQDADVRGLTTLTPVSE 509


>gi|134304856 solute carrier family 6, member 7 [Homo sapiens]
          Length = 636

 Score =  530 bits (1366), Expect = e-150
 Identities = 273/552 (49%), Positives = 363/552 (65%), Gaps = 10/552 (1%)

Query: 27  DGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVF 86
           D    RG+W  K++F+LS  G  +GLGNVWRFPY  Y NGGGAF +PY + L  CGIP+F
Sbjct: 32  DFAAHRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLF 91

Query: 87  LLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTI 146
            LE +LGQ++S G +  W KI P+F+G G A  +IV L+ +YY +++A+ LFYLF+S T 
Sbjct: 92  FLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTS 150

Query: 147 DLPWGGCYHEWNTEHCMEFQKT---NGSLNGTSENATSPVIEFWERRVLKI--SDGIQHL 201
           DLPW  C + WNTE C+E + +   NG+L        SP  E+W R VL I  S GI   
Sbjct: 151 DLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSP 210

Query: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261
           G +RW L LCLLLAWVI + CI KGVKS+GKVVYFTATFPYL+L++LL+RGVTLPGA +G
Sbjct: 211 GEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKG 270

Query: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321
           IQFYL P    L   +VW++A  QIF+S  +  G L    SYN +H N YRD   +   N
Sbjct: 271 IQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGN 330

Query: 322 SGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFF 381
           + TS +AGFAIFS+LG+MSQE GVP+ +VA++GPGLAF+ YP+A+ MLP SP W+  FFF
Sbjct: 331 AITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFF 390

Query: 382 MVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMY 441
           M++ LGLDSQF  +E++VTA+ D +P+  R K  + V    + V  +L+GLI+ T+GGMY
Sbjct: 391 MLLTLGLDSQFAFLETIVTAVTDEFPYYLRPK--KAVFSGLICVAMYLMGLILTTDGGMY 448

Query: 442 VFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTP 501
              L D Y+AS   L+ V I   L V  VYG +RF  +I  M+G++P    + CWLFL+P
Sbjct: 449 WLVLLDDYSAS-FGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSP 507

Query: 502 AVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFR 561
           A   A  ++S++KY P  Y   Y +P W + LG L+ L S + IPA  L  +   +G   
Sbjct: 508 ATLLALMVYSIVKYQPSEYG-SYRFPPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLW 566

Query: 562 ERIRQLMCPAED 573
           ER++Q   PA D
Sbjct: 567 ERLQQASRPAMD 578


>gi|92859670 solute carrier family 6 (neurotransmitter transporter,
           glycine), member 5 [Homo sapiens]
          Length = 797

 Score =  528 bits (1361), Expect = e-150
 Identities = 265/582 (45%), Positives = 368/582 (63%), Gaps = 35/582 (6%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E ++ D    RG+W++K++F+LS+ G  +GLGNVWRFPYL ++NGGGAF IPYL+ L   
Sbjct: 181 EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA 240

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           G+P+F LE +LGQ+ SQG V+ W+ I P  +G G A  +I +L+ +YY +++ + LFYLF
Sbjct: 241 GLPIFFLEVSLGQFASQGPVSVWKAI-PALQGCGIAMLIISVLIAIYYNVIICYTLFYLF 299

Query: 142 SSFTIDLPWGGCYHEWNTEHCME----------------FQKTNGSL------NGTSENA 179
           +SF   LPWG C + WNT  C +                 Q  N +       N T  N 
Sbjct: 300 ASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNF 359

Query: 180 TSPVI--------EFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTG 231
           TS           E+++  VLKIS GI++ G +RW LALCL LAWVI Y  + KG+K++G
Sbjct: 360 TSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419

Query: 232 KVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFA 291
           KVVYFTATFPY++LV+LLIRGVTLPGA  GI +++ P   +L D  VW DA TQIFFS +
Sbjct: 420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLS 479

Query: 292 ICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVA 351
              G L  L SYNK+HNNCYRD + +   NS TS  AGF IFS++GFM+ E+ V I  VA
Sbjct: 480 AAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVA 539

Query: 352 ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFR 411
           + GPG+AF+ YP A+  LP SP WA  FF M++ LGLD+ F  +E++VT++ D +P   R
Sbjct: 540 DQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLR 599

Query: 412 KKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVY 471
               + V  LG  +  F++G  M+T+GG+Y+FQL D YAAS   L+ +AIFE + +++VY
Sbjct: 600 --THKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVY 656

Query: 472 GAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGD 531
           G +RF ++IE MIG++P    K CW F+TP + T    FS  ++ P+TY   Y YP W  
Sbjct: 657 GLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYG-SYRYPNWSM 715

Query: 532 ALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAED 573
            LGWL+   S++ IP   + ++    G F ER++ +  P  D
Sbjct: 716 VLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPD 757


>gi|4557046 solute carrier family 6 member 2 [Homo sapiens]
          Length = 617

 Score =  514 bits (1323), Expect = e-145
 Identities = 253/548 (46%), Positives = 356/548 (64%), Gaps = 12/548 (2%)

Query: 32  RGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETA 91
           R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF IPY +FL   G+P+F +E A
Sbjct: 56  RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELA 115

Query: 92  LGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWG 151
           LGQY  +G  T W KICP F+G+GYA  +I + +  YY +++AW+L+YLFSSFT++LPW 
Sbjct: 116 LGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWT 174

Query: 152 GCYHEWNTEHCMEFQKTNGSLNGT----SENATSPVIEFWERRVLKI--SDGIQHLGALR 205
            C H WN+ +C + +  NGS+ G     S+   +P  EF+ER VL +  S GI  +G  +
Sbjct: 175 DCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQ 234

Query: 206 WELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFY 265
           W+L LCL++  ++ YF +WKGVK++GKVV+ TAT PY +L VLL+ GVTLPGA+ GI  Y
Sbjct: 235 WQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAY 294

Query: 266 LYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTS 325
           L+ +  RL +  VW+DA TQIFFS     G L A  SYNK+ NNCYRD +    +N  TS
Sbjct: 295 LHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITS 354

Query: 326 FVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVL 385
           FV+GFAIFSILG+M+ E  V I +VA  G GL FI YP A+  L  S  WA  FF M++ 
Sbjct: 355 FVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLA 414

Query: 386 LGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQL 445
           LGLDS    +E+++T L D +  +   K  R++   GV+  +FL+ L  +T+GG+YV  L
Sbjct: 415 LGLDSSMGGMEAVITGLADDFQVL---KRHRKLFTFGVTFSTFLLALFCITKGGIYVLTL 471

Query: 446 FDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCT 505
            D +AA G  +LF  + E++ V+W YG  RF ++I+ M+G+RP    + CW F++PA   
Sbjct: 472 LDTFAA-GTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLL 530

Query: 506 ATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIR 565
              + S+I + PLTY+  Y +P W + +GW +ALSSMV +P + +Y+  + +G   ER+ 
Sbjct: 531 FVVVVSIINFKPLTYD-DYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLA 589

Query: 566 QLMCPAED 573
             + P  +
Sbjct: 590 YGITPENE 597


>gi|67782317 solute carrier family 6 member 9 isoform 3 [Homo
           sapiens]
          Length = 633

 Score =  514 bits (1323), Expect = e-145
 Identities = 250/570 (43%), Positives = 364/570 (63%), Gaps = 24/570 (4%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E  + D  L+RG+W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  PY + L  C
Sbjct: 17  EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFC 76

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           GIP+F +E + GQ+ SQG +  WR I P+F+G+GY   ++   + +YY +V+  A +Y F
Sbjct: 77  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 135

Query: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA---------------TSPVIEF 186
           SS T  LPW  C + WNT  C      +   NG+   A               TSP  E+
Sbjct: 136 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEY 195

Query: 187 WERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV 246
           W   VLK+SD I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTATFPY++L 
Sbjct: 196 WRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLT 255

Query: 247 VLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKY 306
           +L +RGVTL GA  GI +YL P   ++ + +VW DA +QIF+S     G L  + SYNK+
Sbjct: 256 ILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF 315

Query: 307 HNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366
           HNNCYRD + +   N  TS  AGF IFSILGFM+   GV +S VA+ GPGLAF+AYP A+
Sbjct: 316 HNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEAL 375

Query: 367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPH--VFRKKNRREVLILGVS 424
            +LP SPLW+  FFFM++LLGL +QF  +E+LVTA+VD   +  + +KK     + LGV+
Sbjct: 376 TLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKT---YVTLGVA 432

Query: 425 VVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 484
           V  FL+G+ + ++ G+Y   L D YAAS   L+ ++    + + ++YG + ++ +I+ M+
Sbjct: 433 VAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMML 491

Query: 485 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVC 544
           G+ P    + CW F++PA+     +F++I+Y P+TYN  Y YP W  A+G+L+ALSS++C
Sbjct: 492 GFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLC 550

Query: 545 IPAWSLYRLGTLKG-PFRERIRQLMCPAED 573
           IP ++++RL    G    +R++    P+ D
Sbjct: 551 IPLYAMFRLCRTDGDTLLQRLKNATKPSRD 580


>gi|67782315 solute carrier family 6 member 9 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  514 bits (1323), Expect = e-145
 Identities = 250/570 (43%), Positives = 364/570 (63%), Gaps = 24/570 (4%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E  + D  L+RG+W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  PY + L  C
Sbjct: 90  EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFC 149

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           GIP+F +E + GQ+ SQG +  WR I P+F+G+GY   ++   + +YY +V+  A +Y F
Sbjct: 150 GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 208

Query: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA---------------TSPVIEF 186
           SS T  LPW  C + WNT  C      +   NG+   A               TSP  E+
Sbjct: 209 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEY 268

Query: 187 WERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV 246
           W   VLK+SD I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTATFPY++L 
Sbjct: 269 WRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLT 328

Query: 247 VLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKY 306
           +L +RGVTL GA  GI +YL P   ++ + +VW DA +QIF+S     G L  + SYNK+
Sbjct: 329 ILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF 388

Query: 307 HNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366
           HNNCYRD + +   N  TS  AGF IFSILGFM+   GV +S VA+ GPGLAF+AYP A+
Sbjct: 389 HNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEAL 448

Query: 367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPH--VFRKKNRREVLILGVS 424
            +LP SPLW+  FFFM++LLGL +QF  +E+LVTA+VD   +  + +KK     + LGV+
Sbjct: 449 TLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKT---YVTLGVA 505

Query: 425 VVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 484
           V  FL+G+ + ++ G+Y   L D YAAS   L+ ++    + + ++YG + ++ +I+ M+
Sbjct: 506 VAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMML 564

Query: 485 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVC 544
           G+ P    + CW F++PA+     +F++I+Y P+TYN  Y YP W  A+G+L+ALSS++C
Sbjct: 565 GFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLC 623

Query: 545 IPAWSLYRLGTLKG-PFRERIRQLMCPAED 573
           IP ++++RL    G    +R++    P+ D
Sbjct: 624 IPLYAMFRLCRTDGDTLLQRLKNATKPSRD 653


>gi|67782313 solute carrier family 6 member 9 isoform 1 [Homo
           sapiens]
          Length = 652

 Score =  514 bits (1323), Expect = e-145
 Identities = 250/570 (43%), Positives = 364/570 (63%), Gaps = 24/570 (4%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E  + D  L+RG+W N++EFVL+  G  +GLGNVWRFPYLCY+NGGGAF  PY + L  C
Sbjct: 36  EATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFC 95

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           GIP+F +E + GQ+ SQG +  WR I P+F+G+GY   ++   + +YY +V+  A +Y F
Sbjct: 96  GIPLFFMELSFGQFASQGCLGVWR-ISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFF 154

Query: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA---------------TSPVIEF 186
           SS T  LPW  C + WNT  C      +   NG+   A               TSP  E+
Sbjct: 155 SSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEY 214

Query: 187 WERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLV 246
           W   VLK+SD I + G +R  L  CL ++W++ + C+ +GVKS+GKVVYFTATFPY++L 
Sbjct: 215 WRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLT 274

Query: 247 VLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKY 306
           +L +RGVTL GA  GI +YL P   ++ + +VW DA +QIF+S     G L  + SYNK+
Sbjct: 275 ILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKF 334

Query: 307 HNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAV 366
           HNNCYRD + +   N  TS  AGF IFSILGFM+   GV +S VA+ GPGLAF+AYP A+
Sbjct: 335 HNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEAL 394

Query: 367 VMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPH--VFRKKNRREVLILGVS 424
            +LP SPLW+  FFFM++LLGL +QF  +E+LVTA+VD   +  + +KK     + LGV+
Sbjct: 395 TLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKT---YVTLGVA 451

Query: 425 VVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMI 484
           V  FL+G+ + ++ G+Y   L D YAAS   L+ ++    + + ++YG + ++ +I+ M+
Sbjct: 452 VAGFLLGIPLTSQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMML 510

Query: 485 GYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVC 544
           G+ P    + CW F++PA+     +F++I+Y P+TYN  Y YP W  A+G+L+ALSS++C
Sbjct: 511 GFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYN-HYQYPGWAVAIGFLMALSSVLC 569

Query: 545 IPAWSLYRLGTLKG-PFRERIRQLMCPAED 573
           IP ++++RL    G    +R++    P+ D
Sbjct: 570 IPLYAMFRLCRTDGDTLLQRLKNATKPSRD 599


>gi|4507041 solute carrier family 6 (neurotransmitter transporter,
           dopamine), member 3 [Homo sapiens]
          Length = 620

 Score =  507 bits (1306), Expect = e-143
 Identities = 246/548 (44%), Positives = 352/548 (64%), Gaps = 11/548 (2%)

Query: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90
           +R  W  K++F+LSV G  + L NVWRFPYLCYKNGGGAF +PYL+F+   G+P+F +E 
Sbjct: 59  DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMEL 118

Query: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150
           ALGQ+  +G    W KICPI +G+G+   +I + +  +Y +++AWAL YLFSSFT +LPW
Sbjct: 119 ALGQFNREGAAGVW-KICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPW 177

Query: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSEN---ATSPVIEFWERRVLKI--SDGIQHLGALR 205
             C + WN+ +C +    + S + +  N    T+P  E++ER VL +  S GI  LG  R
Sbjct: 178 IHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPR 237

Query: 206 WELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFY 265
           W+L  CL+L  V+ YF +WKGVK++GKVV+ TAT PY++L  LL+RGVTLPGA  GI+ Y
Sbjct: 238 WQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297

Query: 266 LYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTS 325
           L  +  RL +  VW+DA TQ+ FS  +  G L A  SYNK+ NNCYRD I    +NS TS
Sbjct: 298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTS 357

Query: 326 FVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVL 385
           F +GF +FS LG+M+Q+  VPI +VA+ GPGL FI YP A+  LP S  WA  FF M++ 
Sbjct: 358 FSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLT 417

Query: 386 LGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQL 445
           LG+DS    +ES++T L+D +  + R    RE+  L + + +FL+ L  +T GG+YVF L
Sbjct: 418 LGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLATFLLSLFCVTNGGIYVFTL 474

Query: 446 FDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCT 505
            D++AA G  +LF  + E++ VAW YG  +F D+I+ M G RP    + CW  ++P    
Sbjct: 475 LDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL 533

Query: 506 ATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIR 565
              + S++ + P  Y   Y +P W +ALGW++A SSM  +P ++ Y+  +L G FRE++ 
Sbjct: 534 FVVVVSIVTFRPPHYG-AYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLA 592

Query: 566 QLMCPAED 573
             + P +D
Sbjct: 593 YAIAPEKD 600


>gi|4507043 solute carrier family 6 member 4 [Homo sapiens]
          Length = 630

 Score =  503 bits (1296), Expect = e-142
 Identities = 250/554 (45%), Positives = 357/554 (64%), Gaps = 11/554 (1%)

Query: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90
           ER  W  K++F+LSV G  + LGNVWRFPY+CY+NGGGAF +PY +     GIP+F +E 
Sbjct: 78  ERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMEL 137

Query: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150
           ALGQY   G ++ WRKICPIF+GIGYA  +I   +  YY  ++AWAL+YL SSFT  LPW
Sbjct: 138 ALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPW 197

Query: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKI--SDGIQHLGALRWEL 208
             C + WNT +C  +   +      + ++TSP  EF+ R VL+I  S G+Q LG + W+L
Sbjct: 198 TSCKNSWNTGNCTNYFSEDNIT--WTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQL 255

Query: 209 ALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYP 268
           ALC++L + + YF IWKGVK++GKVV+ TATFPY++L VLL+RG TLPGA +G+ FYL P
Sbjct: 256 ALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKP 315

Query: 269 NLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVA 328
           N  +L +  VW+DA  QIFFS     G L A  SYNK++NNCY+D +    +N  TSFV+
Sbjct: 316 NWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVS 375

Query: 329 GFAIFSILGFMSQEQGVPISEVA-ESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLG 387
           GF IF++LG+M++ +   +SEVA ++GP L FI Y  A+  +P S  +A  FF M++ LG
Sbjct: 376 GFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLG 435

Query: 388 LDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFD 447
           LDS F  +E ++TA++D +PHV+ K  RRE  +L V +  F   L+ LT GG YV +L +
Sbjct: 436 LDSTFAGLEGVITAVLDEFPHVWAK--RRERFVLAVVITCFFGSLVTLTFGGAYVVKLLE 493

Query: 448 YYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTAT 507
            Y A+G  +L VA+ E++ V+W YG  +F  ++++M+G+ P    + CW+ ++P +    
Sbjct: 494 EY-ATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISP-LFLLF 551

Query: 508 FLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQL 567
            + S +   P     +Y YP+W   LG+ +  SS +CIP +  YRL    G F+ERI + 
Sbjct: 552 IICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKS 611

Query: 568 MCPAEDLPQRNPAG 581
           + P  + P   P G
Sbjct: 612 ITP--ETPTEIPCG 623


>gi|6005715 solute carrier family 6 (amino acid transporter), member
           14 [Homo sapiens]
          Length = 642

 Score =  471 bits (1213), Expect = e-133
 Identities = 241/583 (41%), Positives = 356/583 (61%), Gaps = 40/583 (6%)

Query: 25  EEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIP 84
           E D   +RG+W+ K +++LS+ G  +GLGNVWRFPYL Y NGGGAF IPY + L   G+P
Sbjct: 29  ENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLP 88

Query: 85  VFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSF 144
           +F LE +LGQ+ S G V+ WR I P+F+G+G    +I I + +YY +++A++L+Y+F+SF
Sbjct: 89  LFFLECSLGQFASLGPVSVWR-ILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASF 147

Query: 145 TIDLPWGGCYHEWNTEHC------------------MEFQKTNGS---------LNGTS- 176
             +LPW  C   W+ ++C                   E  + N S         +NG+  
Sbjct: 148 QSELPWKNC-SSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEI 206

Query: 177 -ENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVY 235
            +    P  ++W +  L+ S G+   G + W LALCLLLAW+I    ++KG+KS+GKVVY
Sbjct: 207 YQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVY 266

Query: 236 FTATFPYLMLVVLLIRGVTLPGAAQGIQFYL--YPNLTRLWDPQVWMDAGTQIFFSFAIC 293
           FTA FPY++L++LL+RG TL GA++GI +Y+    N T+L + +VW DA TQIF+S ++ 
Sbjct: 267 FTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVA 326

Query: 294 LGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAES 353
            G L AL SYNK+ NNC+ D I +C  N  TS  AGFAIFSILG M+   G  +S+V +S
Sbjct: 327 WGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKS 386

Query: 354 GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKK 413
           G  LAFIAYP A+  LP  P W+  FFFM++ LGLDSQF  +E++ T + D++P V +K 
Sbjct: 387 GFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKK- 445

Query: 414 NRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGA 473
             R  + LG  +V FL+GL+ +T+ G+Y   L D++ A G  +L  AI E + + W+YG 
Sbjct: 446 -MRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCA-GWGILIAAILELVGIIWIYGG 503

Query: 474 KRFYDNIEDMIGYRPWPL---IKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWG 530
            RF ++ E MIG + W      + CW  +TP +  A F++SL+++    Y     YP WG
Sbjct: 504 NRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYG-AIPYPDWG 562

Query: 531 DALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAED 573
            ALGW + +  ++ IP  ++ ++   KG   +R+     PA +
Sbjct: 563 VALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASN 605


>gi|51468073 solute carrier family 6, member 19 [Homo sapiens]
          Length = 634

 Score =  366 bits (939), Expect = e-101
 Identities = 207/605 (34%), Positives = 306/605 (50%), Gaps = 82/605 (13%)

Query: 16  PVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYL 75
           P    +E  E++    R  W+NK +++L+  G  +GLGNVWRFPYLC  +GGGAF IP+L
Sbjct: 16  PSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFL 75

Query: 76  VFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAW 135
           + L   GIP+  LE A+GQ   +G +  W  I P  +G+G AS +   ++ +YY  +++W
Sbjct: 76  ILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGLASMLTSFMVGLYYNTIISW 135

Query: 136 ALFYLFSSFTIDLPWGGC-YHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKI 194
            ++YLF+SF   LPW  C  +E  T +  E  ++            SPV  FW R  L I
Sbjct: 136 IMWYLFNSFQEPLPWSDCPLNENQTGYVDECARS------------SPVDYFWYRETLNI 183

Query: 195 SDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVT 254
           S  I   G+++W + LCL  AW + Y C  +G+++TGK VY T+T PY++L + LIRG+T
Sbjct: 184 STSISDSGSIQWWMLLCLACAWSVLYMCTIRGIETTGKAVYITSTLPYVVLTIFLIRGLT 243

Query: 255 LPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDC 314
           L GA  GI F   PN+T L  P  W+DAG Q+FFSF++  G L +  SYN  HNNC +D 
Sbjct: 244 LKGATNGIVFLFTPNVTELAQPDTWLDAGAQVFFSFSLAFGGLISFSSYNSVHNNCEKDS 303

Query: 315 IALCFLNSGTSFVAGFAIFSILGF---------------------------MSQEQGVPI 347
           + +  +N  TS      ++S++GF                           ++QE  V +
Sbjct: 304 VIVSIINGFTSVYVAIVVYSVIGFRATQRYDDCFSTNILTLINGFDLPEGNVTQENFVDM 363

Query: 348 SE-------------------------VAESGPGLAFIAYPRAVVMLPFSPLWACCFFFM 382
            +                          A  G GLAFI +  A+  +P SPLW+  FF M
Sbjct: 364 QQRCNASDPAAYAQLVFQTCDINAFLSEAVEGTGLAFIVFTEAITKMPLSPLWSVLFFIM 423

Query: 383 VVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYV 442
           +  LGL S F  +E +V  L D+   V   K  +EVL   + + +FL+G I     G Y 
Sbjct: 424 LFCLGLSSMFGNMEGVVVPLQDL--RVIPPKWPKEVLTGLICLGTFLIGFIFTLNSGQYW 481

Query: 443 FQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPA 502
             L D YA S + LL +A  E   V +VYG  RF  +IE MIG++P    +  W  ++P 
Sbjct: 482 LSLLDSYAGS-IPLLIIAFCEMFSVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPL 540

Query: 503 VCTATFLFSLI--------------KYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAW 548
           +    FLF  +               Y     ++K +YP W   +  ++A    + IP +
Sbjct: 541 LMLIIFLFFFVVEVSQELTYSIWDPGYEEFPKSQKISYPNWVYVVVVIVAGVPSLTIPGY 600

Query: 549 SLYRL 553
           ++Y+L
Sbjct: 601 AIYKL 605


>gi|194018524 solute carrier family 6, member 18 [Homo sapiens]
          Length = 628

 Score =  362 bits (929), Expect = e-100
 Identities = 219/628 (34%), Positives = 324/628 (51%), Gaps = 83/628 (13%)

Query: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90
           ER  W+NK +++LS  G  +GLGN+WRFPYLC   GGGAF IPY++ L   GIP+F +E 
Sbjct: 17  ERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVEL 76

Query: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150
           A+GQ   +G V  W  I P   G+G     +  L+++YY  ++AW L+YL +SF   LPW
Sbjct: 77  AIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPW 136

Query: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELAL 210
             C  + N    +E  +  GS         S V  FW R+ L I+  I   G+++W L +
Sbjct: 137 SSCPPDLNRTGFVE--ECQGS---------SAVSYFWYRQTLNITADINDSGSIQWWLLI 185

Query: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270
           CL  +W + Y C+ +G+++TGKV+YFTA FPYL+L + LIRG+TLPGA +G+ +   PN+
Sbjct: 186 CLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNM 245

Query: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330
             L +P+VW+DA TQIFFS ++  G   A  SYN   N+C +D + +  +N  TS  A  
Sbjct: 246 HILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASI 305

Query: 331 AIFSILGFMS---------------------QEQGV-----------------------P 346
           A+FS+LGF +                      EQ +                       P
Sbjct: 306 AVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLP 365

Query: 347 IS--------EVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398
           +         + + SGPGLAF+ +    + +P +P+WA  FF M+  LGL + F  VE++
Sbjct: 366 LKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAV 425

Query: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458
           +T L+D+   V  +   +E L   V +V FL       + G Y  ++FD +AAS   LL 
Sbjct: 426 ITPLLDV--GVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPN-LLM 482

Query: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLF-SLIKYTP 517
           +A  E + V +VYG KRF D+I  M G RP P  +  W  ++P + T    +  L+ + P
Sbjct: 483 LAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKP 542

Query: 518 LTY---NKKY---------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT-LKGPFRERI 564
           L Y   N KY          YP W  A   LL+L  ++ +P  +L +L T  +  +R+R 
Sbjct: 543 LRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRD 602

Query: 565 RQLMCPAEDLPQRNPAGPSAPATPRTSL 592
            +   P  D+       P     P T +
Sbjct: 603 AR---PDTDMRPDTDTRPDTDMRPDTDM 627


>gi|11181770 solute carrier family 6, member 20 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  340 bits (872), Expect = 2e-93
 Identities = 204/590 (34%), Positives = 293/590 (49%), Gaps = 89/590 (15%)

Query: 35  WNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQ 94
           W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY++ L   G+P+  LE A+GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 95  YTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCY 154
              QG + AWR I P   G+G AS ++   L++YY ++ AWA +YLF SF   LPW  C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 155 HEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHLGALRWELALCL 212
                         NG+  G  E     S    FW R+ L IS  +Q  G ++WE ALCL
Sbjct: 127 ------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCL 174

Query: 213 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTR 272
           LLAW++ Y CI +G +STGKVVYFTA+ PY +L++ LIRG+TL GA  G+ +   P + +
Sbjct: 175 LLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQ 234

Query: 273 LWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAI 332
           L +P+ W++A TQIFFS  +  G L A  SYN+  NNC +  I +  +NS TS  A    
Sbjct: 235 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVT 294

Query: 333 FSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAYP--------- 363
           FSI GF +                     E G   +   E   G    AYP         
Sbjct: 295 FSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ 354

Query: 364 -------------------------RAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398
                                     A+  +  S LW+  +FFM+++LG+ S      ++
Sbjct: 355 IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 414

Query: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458
           +T L D    +      +E +   V +V+  +G++   E G Y F +F+ YAA+ + LL 
Sbjct: 415 LTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLL 471

Query: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPL 518
           + + E++ V +VYG +RF  +++ M G       K  W  ++P +  + F+F L  Y  L
Sbjct: 472 IVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYI-L 530

Query: 519 TYNKKY-------------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT 555
           T   KY              YP +  A+  LL  SS +CIP   L  LGT
Sbjct: 531 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP---LAALGT 577


>gi|58219014 solute carrier family 6, member 17 [Homo sapiens]
          Length = 727

 Score =  283 bits (724), Expect = 3e-76
 Identities = 133/317 (41%), Positives = 191/317 (60%), Gaps = 13/317 (4%)

Query: 24  KEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGI 83
           +EE    +R  WN+K++++L+  G  +GLGN+WRFPYLC KNGGGA+ +PYLV L   GI
Sbjct: 52  EEELDAEDRPAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGI 111

Query: 84  PVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSS 143
           P+F LE A+GQ   +G +  W  ICP   GIG++S ++ + + +YY +++ W++FY F S
Sbjct: 112 PLFFLELAVGQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKS 171

Query: 144 FTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHL 201
           F   LPW  C               NGS+         +S    FW R  L ISD I   
Sbjct: 172 FQYPLPWSECP-----------VVRNGSVAVVEAECEKSSATTYFWYREALDISDSISES 220

Query: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261
           G L W++ LCLL+AW I    + KG++S+GKV+YF++ FPY++L   L+RG+ L GA  G
Sbjct: 221 GGLNWKMTLCLLVAWSIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDG 280

Query: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321
           I     P L ++ DPQVW +A TQ+FF+  +  G + A  SYNK  NNC+ D   + F+N
Sbjct: 281 ILHMFTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFIN 340

Query: 322 SGTSFVAGFAIFSILGF 338
             TS +A   +F++LGF
Sbjct: 341 FFTSVLATLVVFAVLGF 357



 Score =  116 bits (290), Expect = 7e-26
 Identities = 68/204 (33%), Positives = 108/204 (52%), Gaps = 18/204 (8%)

Query: 354 GPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKK 413
           G GLAFIA+  A+   P SP W+  FF M++ LGL S    +  + T ++D +      K
Sbjct: 437 GTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTF------K 490

Query: 414 NRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGA 473
             +E+  +G  V +FLVGL+ +   G Y   +FD Y+A+ + L  + I E++ VAW+YG 
Sbjct: 491 VPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSAT-LPLTLIVILENIAVAWIYGT 549

Query: 474 KRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN--------KK 523
           K+F   + +M+G+RP+    Y W F++P         S+I+   TP  Y+        ++
Sbjct: 550 KKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAER 609

Query: 524 YTY-PWWGDALGWLLALSSMVCIP 546
           Y Y P W  AL   L + + + IP
Sbjct: 610 YLYFPNWAMALLITLIVVATLPIP 633


>gi|12408638 solute carrier family 6, member 20 isoform 2 [Homo
           sapiens]
          Length = 555

 Score =  281 bits (719), Expect = 1e-75
 Identities = 185/590 (31%), Positives = 267/590 (45%), Gaps = 126/590 (21%)

Query: 35  WNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQ 94
           W N ++FV +     +GLGNVWRFPYLC   GGG+F +PY++ L   G+P+  LE A+GQ
Sbjct: 8   WANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQ 67

Query: 95  YTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCY 154
              QG + AWR I P   G+G AS ++   L++YY ++ AWA +YLF SF   LPW  C 
Sbjct: 68  RMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVC- 126

Query: 155 HEWNTEHCMEFQKTNGSLNGTSENA--TSPVIEFWERRVLKISDGIQHLGALRWELALCL 212
                         NG+  G  E     S    FW R+ L IS  +Q  G ++WE ALCL
Sbjct: 127 ------------PLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCL 174

Query: 213 LLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTR 272
           LLAW++ Y CI +G +STGK+                                      +
Sbjct: 175 LLAWLVVYLCILRGTESTGKI-------------------------------------EQ 197

Query: 273 LWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAI 332
           L +P+ W++A TQIFFS  +  G L A  SYN+  NNC +  I +  +NS TS  A    
Sbjct: 198 LANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVT 257

Query: 333 FSILGFMSQ--------------------EQGVPISEVAESGPGLAFIAYP--------- 363
           FSI GF +                     E G   +   E   G    AYP         
Sbjct: 258 FSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQ 317

Query: 364 -------------------------RAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESL 398
                                     A+  +  S LW+  +FFM+++LG+ S      ++
Sbjct: 318 IKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 377

Query: 399 VTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLF 458
           +T L D    +      +E +   V +V+  +G++   E G Y F +F+ YAA+ + LL 
Sbjct: 378 LTPLTD--SKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLL 434

Query: 459 VAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPL 518
           + + E++ V +VYG +RF  +++ M G       K  W  ++P +  + F+F L  Y  L
Sbjct: 435 IVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYI-L 493

Query: 519 TYNKKY-------------TYPWWGDALGWLLALSSMVCIPAWSLYRLGT 555
           T   KY              YP +  A+  LL  SS +CIP   L  LGT
Sbjct: 494 TGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIP---LAALGT 540


>gi|33354281 solute carrier family 6, member 15 isoform 1 [Homo
           sapiens]
          Length = 730

 Score =  268 bits (686), Expect = 8e-72
 Identities = 124/308 (40%), Positives = 183/308 (59%), Gaps = 9/308 (2%)

Query: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90
           ER  WN+K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PYL+ L   GIP+F LE 
Sbjct: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119

Query: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150
           ++GQ   +G +  W  I P   GIG+AS ++   + +YY +++ W+LFY   SF   LPW
Sbjct: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179

Query: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELAL 210
             C    N  H     +   S         S    +W R  L IS  I   G L W++ +
Sbjct: 180 DQCPLVKNASHTFVEPECEQS---------SATTYYWYREALNISSSISESGGLNWKMTI 230

Query: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNL 270
           CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+  GI+    P L
Sbjct: 231 CLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKL 290

Query: 271 TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGF 330
             + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + F+N  TS +A  
Sbjct: 291 EIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATL 350

Query: 331 AIFSILGF 338
            +F++LGF
Sbjct: 351 VVFAVLGF 358



 Score =  120 bits (300), Expect = 5e-27
 Identities = 69/213 (32%), Positives = 117/213 (54%), Gaps = 18/213 (8%)

Query: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410
           A  G GLAFIA+  A+   P SP W+  FF M+V LGL S F  +E +VT +VD +    
Sbjct: 435 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 490

Query: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470
             K R+E+L +   +++F +GLI +   G Y   +FD Y+A+ + LL V I E++ V +V
Sbjct: 491 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 547

Query: 471 YGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN------- 521
           YG  +F ++++DM+G+ P     Y W +++P +  +  + S++    +P  YN       
Sbjct: 548 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 607

Query: 522 --KKYTYPWWGDALGWLLALSSMVCIPAWSLYR 552
             +  +YP WG  +   L + +++ +P   + R
Sbjct: 608 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 640


>gi|197276625 solute carrier family 6 (neurotransmitter transporter,
           taurine), member 6 isoform b [Homo sapiens]
          Length = 200

 Score =  232 bits (592), Expect = 6e-61
 Identities = 107/170 (62%), Positives = 128/170 (75%), Gaps = 3/170 (1%)

Query: 22  EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTC 81
           E + E    +R  W++K++FVLSVAG  +GLGNVWRFPYLCYKNGGGAF IPY +FLF  
Sbjct: 31  EDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGS 90

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           G+PVF LE  +GQYTS+GG+T W KICP+F GIGYAS +IV LLNVYYI++LAWA +YLF
Sbjct: 91  GLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLF 150

Query: 142 SSFTIDLPWGGCYHEWNTEHCME-FQKTNGS--LNGTSENATSPVIEFWE 188
            SF  +LPW  C H WNT HCME   + N S  +  +S N TSPVIEFWE
Sbjct: 151 QSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWE 200


>gi|226437581 solute carrier family 6, member 15 isoform 3 [Homo
           sapiens]
          Length = 623

 Score =  198 bits (504), Expect = 1e-50
 Identities = 95/257 (36%), Positives = 144/257 (56%), Gaps = 9/257 (3%)

Query: 82  GIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLF 141
           GIP+F LE ++GQ   +G +  W  I P   GIG+AS ++   + +YY +++ W+LFY  
Sbjct: 4   GIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFS 63

Query: 142 SSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHL 201
            SF   LPW  C    N  H     +   S         S    +W R  L IS  I   
Sbjct: 64  QSFQQPLPWDQCPLVKNASHTFVEPECEQS---------SATTYYWYREALNISSSISES 114

Query: 202 GALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQG 261
           G L W++ +CLL AWV+    + KG++S+GK++YF++ FPY++L+  LIR   L G+  G
Sbjct: 115 GGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDG 174

Query: 262 IQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLN 321
           I+    P L  + +P+VW +A TQ+FF+  +  G + A  SYNK  NNC+ D + + F+N
Sbjct: 175 IRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFIN 234

Query: 322 SGTSFVAGFAIFSILGF 338
             TS +A   +F++LGF
Sbjct: 235 FFTSVLATLVVFAVLGF 251



 Score =  120 bits (300), Expect = 5e-27
 Identities = 69/213 (32%), Positives = 117/213 (54%), Gaps = 18/213 (8%)

Query: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410
           A  G GLAFIA+  A+   P SP W+  FF M+V LGL S F  +E +VT +VD +    
Sbjct: 328 AVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIVTPIVDTF---- 383

Query: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWV 470
             K R+E+L +   +++F +GLI +   G Y   +FD Y+A+ + LL V I E++ V +V
Sbjct: 384 --KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSAT-LPLLIVVILENIAVCFV 440

Query: 471 YGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTYN------- 521
           YG  +F ++++DM+G+ P     Y W +++P +  +  + S++    +P  YN       
Sbjct: 441 YGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYNAWIEDKA 500

Query: 522 --KKYTYPWWGDALGWLLALSSMVCIPAWSLYR 552
             +  +YP WG  +   L + +++ +P   + R
Sbjct: 501 SEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVR 533


>gi|55749589 solute carrier family 6, member 16 [Homo sapiens]
          Length = 736

 Score =  188 bits (478), Expect = 1e-47
 Identities = 111/334 (33%), Positives = 168/334 (50%), Gaps = 14/334 (4%)

Query: 8   TTSNGETKPVYP---VMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYK 64
           T S    KP +    + EKKE +  L R  W++K E++L+  G  +    +WRF YL   
Sbjct: 76  TASALNQKPTHEKVQMTEKKESEVLLARPFWSSKTEYILAQVGFSMKPSCLWRFAYLWLN 135

Query: 65  NGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVIL 124
           +GG +F   Y+  LF  G+P+  LE A GQ   QGG+  W+ I P   G+GY+S M+  +
Sbjct: 136 SGGCSFAAIYIFMLFLVGVPLLFLEMAAGQSMRQGGMGVWKIIAPWIGGVGYSSFMVCFI 195

Query: 125 LNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVI 184
           L +Y+ +V +W +FY+  SF   +PW  C    N          +   +   E  T+P I
Sbjct: 196 LGLYFNVVNSWIIFYMSQSFQFPVPWEKCPLTMN----------SSGFDPECER-TTPSI 244

Query: 185 EFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLM 244
            FW ++ LK SD I+  G+  + L L   L W +    +  G+KSTGKV+Y     P  +
Sbjct: 245 YFWYQQALKASDRIEDGGSPVYSLVLPFFLCWCLVGAFMINGLKSTGKVIYVLVLLPCFI 304

Query: 245 LVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYN 304
           +V   IR + L GA  G+Q  +   ++ +++  VW  AG Q+  +  I LG + +L SY 
Sbjct: 305 IVGFFIRTLLLEGAKFGLQQLVVAKISDVYNMSVWSLAGGQVLSNTGIGLGSVASLASYM 364

Query: 305 KYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGF 338
              NNC  D   +  +N  T  V     F +LGF
Sbjct: 365 PQSNNCLSDAFLVSVINLLTLLVFTSFNFCVLGF 398



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 73/254 (28%), Positives = 122/254 (48%), Gaps = 35/254 (13%)

Query: 351 AESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVF 410
           A  GP  AF+++  A+  LP S  W+  FF M++ +GL S    ++ ++T L D +   F
Sbjct: 473 ASEGPKFAFLSFVEAMSFLPPSVFWSFIFFLMLLAMGLSSAIGIMQGIITPLQDTFSF-F 531

Query: 411 RKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLF-DYYAASGMCLLFVAIFESLCVAW 469
           RK  +  +LI+GV ++ F+ GL      G Y  +L  DY+      ++ V +FE++ V+W
Sbjct: 532 RKHTK--LLIVGVFLLMFVCGLFFTRPSGSYFIRLLSDYWIV--FPIIVVVVFETMAVSW 587

Query: 470 VYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIK--YTPLTY------- 520
            YGA+RF  ++  ++G+   P+  + W  L P V    F+  ++     P+TY       
Sbjct: 588 AYGARRFLADLTILLGHPISPIFGWLWPHLCPVVLLIIFVTMMVHLCMKPITYMSWDSST 647

Query: 521 NKKYTYPWWGDALGWLLALSSMVC--IPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRN 578
           +K+   P+   AL  ++ L ++V   IPA+ +Y                 C    +P R 
Sbjct: 648 SKEVLRPYPPWALLLMITLFAIVILPIPAYFVY-----------------CRIHRIPFR- 689

Query: 579 PAGPSAPATPRTSL 592
           P     P T  TSL
Sbjct: 690 PKSGDGPMTASTSL 703


>gi|21361693 solute carrier family 6, member 15 isoform 2 [Homo
           sapiens]
          Length = 289

 Score =  180 bits (457), Expect = 3e-45
 Identities = 86/219 (39%), Positives = 126/219 (57%), Gaps = 12/219 (5%)

Query: 31  ERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLET 90
           ER  WN+K++++L+  G  +GLGNVWRFPYLC KNGGGA+ +PYL+ L   GIP+F LE 
Sbjct: 60  ERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLEL 119

Query: 91  ALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPW 150
           ++GQ   +G +  W  I P   GIG+AS ++   + +YY +++ W+LFY   SF   LPW
Sbjct: 120 SVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPW 179

Query: 151 GGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELAL 210
             C    N  H     +   S         S    +W R  L IS  I   G L W++ +
Sbjct: 180 DQCPLVKNASHTFVEPECEQS---------SATTYYWYREALNISSSISESGGLNWKMTI 230

Query: 211 CLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLL 249
           CLL AWV+    + KG++S+GKV   +   P+L+L++ +
Sbjct: 231 CLLAAWVMVCLAMIKGIQSSGKV---SMLEPFLILLITI 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.143    0.479 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,622,518
Number of Sequences: 37866
Number of extensions: 1052720
Number of successful extensions: 3261
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3111
Number of HSP's gapped (non-prelim): 57
length of query: 602
length of database: 18,247,518
effective HSP length: 108
effective length of query: 494
effective length of database: 14,157,990
effective search space: 6994047060
effective search space used: 6994047060
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.