Guide to the Human Genome
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Search of human proteins with 20357556

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20357556 cortactin isoform b [Homo sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20357556 cortactin isoform b [Homo sapiens]                       1050   0.0  
gi|20357552 cortactin isoform a [Homo sapiens]                       1032   0.0  
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s...   415   e-116
gi|62198235 drebrin-like isoform b [Homo sapiens]                     103   5e-22
gi|21361670 drebrin-like isoform a [Homo sapiens]                     102   6e-22
gi|171906575 drebrin-like isoform c [Homo sapiens]                    100   4e-21
gi|5453710 LIM and SH3 protein 1 [Homo sapiens]                        66   7e-11
gi|115527120 nebulin [Homo sapiens]                                    64   4e-10
gi|24308229 protein kinase C and casein kinase substrate in neur...    62   2e-09
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]         61   2e-09
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]         61   2e-09
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]         61   2e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...    60   4e-09
gi|109689723 abl interactor 2 [Homo sapiens]                           60   5e-09
gi|5453758 nebulette sarcomeric isoform [Homo sapiens]                 59   1e-08
gi|47087157 nebulette non-muscle isoform [Homo sapiens]                59   1e-08
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                58   2e-08
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                58   2e-08
gi|61743948 abl-interactor 1 isoform d [Homo sapiens]                  58   2e-08
gi|61743946 abl-interactor 1 isoform c [Homo sapiens]                  58   2e-08
gi|61743944 abl-interactor 1 isoform b [Homo sapiens]                  58   2e-08
gi|61743942 abl-interactor 1 isoform a [Homo sapiens]                  58   2e-08
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        55   1e-07
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    55   2e-07
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...    55   2e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             55   2e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]             55   2e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]        55   2e-07
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                     55   2e-07
gi|55956916 myosin IE [Homo sapiens]                                   55   2e-07

>gi|20357556 cortactin isoform b [Homo sapiens]
          Length = 513

 Score = 1050 bits (2716), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
           MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
Sbjct: 1   MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60

Query: 61  NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
           NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
Sbjct: 61  NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120

Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
           FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
Sbjct: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180

Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
           KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
Sbjct: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240

Query: 241 DRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKT 300
           DRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKT
Sbjct: 241 DRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKT 300

Query: 301 VPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARA 360
           VPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARA
Sbjct: 301 VPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARA 360

Query: 361 KTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREAS 420
           KTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREAS
Sbjct: 361 KTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREAS 420

Query: 421 SQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDD 480
           SQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDD
Sbjct: 421 SQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDD 480

Query: 481 IITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 513
           IITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
Sbjct: 481 IITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 513


>gi|20357552 cortactin isoform a [Homo sapiens]
          Length = 550

 Score = 1032 bits (2668), Expect = 0.0
 Identities = 513/550 (93%), Positives = 513/550 (93%), Gaps = 37/550 (6%)

Query: 1   MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
           MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
Sbjct: 1   MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60

Query: 61  NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
           NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
Sbjct: 61  NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120

Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
           FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
Sbjct: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180

Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
           KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
Sbjct: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240

Query: 241 DRQDKCALGWDHQEKLQLHESQKDY----------------------------------- 265
           DRQDKCALGWDHQEKLQLHESQKDY                                   
Sbjct: 241 DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ 300

Query: 266 --SKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 323
             SKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
Sbjct: 301 DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 360

Query: 324 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 383
           KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
Sbjct: 361 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 420

Query: 384 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 443
           YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
Sbjct: 421 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 480

Query: 444 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 503
           AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
Sbjct: 481 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 540

Query: 504 FPANYVELRQ 513
           FPANYVELRQ
Sbjct: 541 FPANYVELRQ 550


>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
           sapiens]
          Length = 486

 Score =  415 bits (1066), Expect = e-116
 Identities = 233/547 (42%), Positives = 304/547 (55%), Gaps = 99/547 (18%)

Query: 1   MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
           MWK+  GH VS++ +  G DDW+TDPDFVND+SEKEQRWGAKT++GSG  EHINIH+LR 
Sbjct: 1   MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN 59

Query: 61  NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
            V +EH  L++KE+E+GPKASHGYGG+FGVE+DRMDKSAVGHEY +++ KH SQ D+ +G
Sbjct: 60  KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG 119

Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
           FGGK+GV+ DR D+SAVGF+Y+G+ EKH SQKDYS GFGG+YGV+ D+ DK+A+G+DY+G
Sbjct: 120 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG 179

Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ 239
           +TEKHESQRDY+KGFGG+YGI KD+VDKSAVGF E +  T  ++          G  G++
Sbjct: 180 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLK 239

Query: 240 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK 299
              +         +EK +  E +K                            QV+   Q 
Sbjct: 240 AKFESMA------EEKRKREEEEK--------------------------AQQVARRQQ- 266

Query: 300 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR 359
                                  E++   +R  EA +     +E        +K+  +A 
Sbjct: 267 -----------------------ERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAW 303

Query: 360 AKTQTPPVS---PAPQPTEERLPSSPVYEDAASFKAELSYRGPVS----GTEPEPVYSME 412
               TPP S   P     E  +P  P+ +       E     P +      E EPVY  E
Sbjct: 304 PPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAE 363

Query: 413 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYEN------------------ 454
                E   +       E  YE  E    +  ED    +YE                   
Sbjct: 364 PEPEPEPEPE------PENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSG 417

Query: 455 ----------DLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLF 504
                      LGI+AVALYDYQ  G DE+SFDPDD+IT+IEM+D+GWWRG C G +GLF
Sbjct: 418 CPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLF 477

Query: 505 PANYVEL 511
           PANYV+L
Sbjct: 478 PANYVKL 484


>gi|62198235 drebrin-like isoform b [Homo sapiens]
          Length = 430

 Score =  103 bits (256), Expect = 5e-22
 Identities = 93/307 (30%), Positives = 128/307 (41%), Gaps = 72/307 (23%)

Query: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 322
           +K  G  Y   K+     +  F+DV     V S YQKT  V    S+   +  +      
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183

Query: 323 EKEQEDRR---KAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP---------- 369
           EKE+E+RR   K  AE AQR  ++ + + E R     + R + Q    SP          
Sbjct: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243

Query: 370 -------------------------------APQPTEERLP------SSPVY----EDAA 388
                                          +PQP + R P      + P      E AA
Sbjct: 244 VSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAA 303

Query: 389 SF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAE 445
           +    +A+L    P   T P  V + E A Y E   Q+        V +      H   +
Sbjct: 304 AISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--D 361

Query: 446 DSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLF 504
                +  +  G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG    G +G+F
Sbjct: 362 HHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMF 421

Query: 505 PANYVEL 511
           PANYVEL
Sbjct: 422 PANYVEL 428


>gi|21361670 drebrin-like isoform a [Homo sapiens]
          Length = 431

 Score =  102 bits (255), Expect = 6e-22
 Identities = 93/308 (30%), Positives = 128/308 (41%), Gaps = 73/308 (23%)

Query: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 322
           +K  G  Y   K+     +  F+DV     V S YQKT  V    S+   +  +      
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183

Query: 323 EKEQEDRR---KAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP---------- 369
           EKE+E+RR   K  AE AQR  ++ + + E R     + R + Q    SP          
Sbjct: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243

Query: 370 --------------------------------APQPTEERLP------SSPVY----EDA 387
                                           +PQP + R P      + P      E A
Sbjct: 244 VVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPA 303

Query: 388 ASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPA 444
           A+    +A+L    P   T P  V + E A Y E   Q+        V +      H   
Sbjct: 304 AAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI-- 361

Query: 445 EDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGL 503
           +     +  +  G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG    G +G+
Sbjct: 362 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM 421

Query: 504 FPANYVEL 511
           FPANYVEL
Sbjct: 422 FPANYVEL 429


>gi|171906575 drebrin-like isoform c [Homo sapiens]
          Length = 439

 Score =  100 bits (248), Expect = 4e-21
 Identities = 97/317 (30%), Positives = 130/317 (41%), Gaps = 83/317 (26%)

Query: 266 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 322
           +K  G  Y   K+     +  F+DV     V S YQKT  V    S+   +  +      
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183

Query: 323 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR----------------------- 359
           EKE+E+RR  E  RA+  A+ + EQE   R+L E AR                       
Sbjct: 184 EKEEENRRLEEKRRAEE-AQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQ 242

Query: 360 --------------AKTQTPPVSP-----------------APQPTEERLP------SSP 382
                         A  Q   V P                 +PQP + R P      + P
Sbjct: 243 EVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQP 302

Query: 383 VY----EDAASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYES 435
                 E AA+    +A+L    P   T P  V + E A Y E   Q+        V + 
Sbjct: 303 ETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 362

Query: 436 AEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRG 495
                H   +     +  +  G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG
Sbjct: 363 GAGSEHI--DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420

Query: 496 V-CKGRYGLFPANYVEL 511
               G +G+FPANYVEL
Sbjct: 421 YGPDGHFGMFPANYVEL 437


>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
          Length = 261

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 57/203 (28%), Positives = 88/203 (43%), Gaps = 33/203 (16%)

Query: 332 AEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQ-----PTEERLPSSPVYED 386
           A+     R+ ++ + Q + R K E +         V+  P+      T++++ +   +E+
Sbjct: 66  ADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEE 125

Query: 387 AASFKAELSYRGPVSGT--EPEPVYSMEAADYREASSQQGLAY--ATEAVYESAEAPGHY 442
                 E S  GP  G   EPE   S + + YR    QQ   +   +  VY+    P   
Sbjct: 126 F-----EKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQ---PQQQ 177

Query: 443 PAEDSTYDEYENDLGITAV-------------ALYDYQAAGDDEISFDPDDIITNIEMID 489
           P   S Y  Y+      ++             A+YDY AA +DE+SF   D I N++ ID
Sbjct: 178 PVAQS-YGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQID 236

Query: 490 DGWWRGVCK--GRYGLFPANYVE 510
           DGW  G  +  G  G+ PANYVE
Sbjct: 237 DGWMYGTVERTGDTGMLPANYVE 259


>gi|115527120 nebulin [Homo sapiens]
          Length = 6669

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 13/123 (10%)

Query: 400  VSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESA---EAPGHYPAEDSTYD------ 450
            +SG E +  +S EA D+  ++   G  +A    Y+ A   E P    +  +T        
Sbjct: 6546 ISGGEEKSEHS-EAPDHHLSTYSDGGVFAVSTAYKHAKTTELPQQRSSSVATQQTTVSSI 6604

Query: 451  -EYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCK--GRYGLFPAN 507
              + +  G    A+YDY AA  DE+SF   D I N++ ID+GW  G  +  GR G+ PAN
Sbjct: 6605 PSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPAN 6664

Query: 508  YVE 510
            YVE
Sbjct: 6665 YVE 6667


>gi|24308229 protein kinase C and casein kinase substrate in neurons
           1 [Homo sapiens]
          Length = 444

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 71/265 (26%), Positives = 110/265 (41%), Gaps = 40/265 (15%)

Query: 276 QKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKA--- 332
           QK   DK     +DV +    Y+K +  E V   T     N E + ++ +Q + ++    
Sbjct: 188 QKKLQDKVDKCKQDVQKTQEKYEKVL--EDVGKTTPQYMENMEQVFEQCQQFEEKRLVFL 245

Query: 333 -----EAERAQRMAKERQEQEEARRKLEEQARA----------KTQTPPVSPAPQPTEER 377
                + +R   +A E        R+LE+  R           ++ + P  P   P  E 
Sbjct: 246 KEVLLDIKRHLNLA-ENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEE 304

Query: 378 ----LPSSPVYEDAASFKAE----LSYRGPVSGTEPEPVYSMEAADYREASS-QQGLAYA 428
               LP +   ++    KAE     +  G V  T        +A D    SS  +G  YA
Sbjct: 305 WNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTS-------QAGDRGSVSSYDRGQPYA 357

Query: 429 TEAVYESAEAPGHYPAEDSTYDEYENDL-GITAVALYDYQAAGDDEISFDPDDIITNI-E 486
           TE   + +  P      +   + +E+D  G+   ALYDY     DE+SF   D +T + E
Sbjct: 358 TEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE 417

Query: 487 MIDDGWWRG-VCKGRYGLFPANYVE 510
             + GW RG +  G+ GL+PANYVE
Sbjct: 418 EDEQGWCRGRLDSGQLGLYPANYVE 442


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 26/57 (45%), Positives = 36/57 (63%)

Query: 457 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 513
           G  A ALYD++   +DE+SF   DIIT +E +DD W  G   G+ G+FP NY++  Q
Sbjct: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 729



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)

Query: 325 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 384
           +Q +    E ++ +   +    Q +    L+E  R++   P  S A +P +   P + V 
Sbjct: 387 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 444

Query: 385 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 441
            D  + + +      ++ T  E VY +E  D   YR     Q   +    V    + P  
Sbjct: 445 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 499

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
              +      +    G   VA ++Y     DE+SF   +II   E +++ W RG  +GR 
Sbjct: 500 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 558

Query: 502 GLFPANYVE 510
           G+FP N+VE
Sbjct: 559 GIFPLNFVE 567



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 21/52 (40%), Positives = 35/52 (67%)

Query: 460 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 511
           AV L+D+ A   D+++    +I+  +E ID  W+RG C+ + G+FPANYV++
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 492



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 435 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 493
           S + P     EDS  +   N L      AL+ + A   D++SF   D I  +E +D  W 
Sbjct: 581 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 640

Query: 494 RGVCKGRYGLFPANYV 509
           RG  + R G+FPA +V
Sbjct: 641 RGRLQDREGIFPAVFV 656


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 26/57 (45%), Positives = 36/57 (63%)

Query: 457 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 513
           G  A ALYD++   +DE+SF   DIIT +E +DD W  G   G+ G+FP NY++  Q
Sbjct: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 765



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)

Query: 325 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 384
           +Q +    E ++ +   +    Q +    L+E  R++   P  S A +P +   P + V 
Sbjct: 423 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 480

Query: 385 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 441
            D  + + +      ++ T  E VY +E  D   YR     Q   +    V    + P  
Sbjct: 481 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 535

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
              +      +    G   VA ++Y     DE+SF   +II   E +++ W RG  +GR 
Sbjct: 536 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 594

Query: 502 GLFPANYVE 510
           G+FP N+VE
Sbjct: 595 GIFPLNFVE 603



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 21/52 (40%), Positives = 35/52 (67%)

Query: 460 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 511
           AV L+D+ A   D+++    +I+  +E ID  W+RG C+ + G+FPANYV++
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 528



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 435 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 493
           S + P     EDS  +   N L      AL+ + A   D++SF   D I  +E +D  W 
Sbjct: 617 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 676

Query: 494 RGVCKGRYGLFPANYV 509
           RG  + R G+FPA +V
Sbjct: 677 RGRLQDREGIFPAVFV 692


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 26/57 (45%), Positives = 36/57 (63%)

Query: 457 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 513
           G  A ALYD++   +DE+SF   DIIT +E +DD W  G   G+ G+FP NY++  Q
Sbjct: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 788



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)

Query: 325 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 384
           +Q +    E ++ +   +    Q +    L+E  R++   P  S A +P +   P + V 
Sbjct: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 503

Query: 385 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 441
            D  + + +      ++ T  E VY +E  D   YR     Q   +    V    + P  
Sbjct: 504 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 558

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
              +      +    G   VA ++Y     DE+SF   +II   E +++ W RG  +GR 
Sbjct: 559 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 617

Query: 502 GLFPANYVE 510
           G+FP N+VE
Sbjct: 618 GIFPLNFVE 626



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 21/52 (40%), Positives = 35/52 (67%)

Query: 460 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 511
           AV L+D+ A   D+++    +I+  +E ID  W+RG C+ + G+FPANYV++
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 551



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 435 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 493
           S + P     EDS  +   N L      AL+ + A   D++SF   D I  +E +D  W 
Sbjct: 640 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 699

Query: 494 RGVCKGRYGLFPANYV 509
           RG  + R G+FPA +V
Sbjct: 700 RGRLQDREGIFPAVFV 715


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
           sapiens]
          Length = 665

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 26/52 (50%), Positives = 33/52 (63%)

Query: 458 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYV 509
           + A+  +DYQA  DDE++    +IITNI   D GWW G   GR GLFP N+V
Sbjct: 2   VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 23/51 (45%), Positives = 33/51 (64%), Gaps = 2/51 (3%)

Query: 463 LYDYQAAGDDEISFDPDDIIT--NIEMIDDGWWRGVCKGRYGLFPANYVEL 511
           ++ Y+A  DDE++    DI+T  N + ID GWW G   GR G+FP N+V+L
Sbjct: 275 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 325



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 17/47 (36%), Positives = 29/47 (61%)

Query: 464 YDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
           + Y    DDE+     DII  +  +++GWW GV  G+ G+FP+N+++
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153


>gi|109689723 abl interactor 2 [Homo sapiens]
          Length = 475

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 50/153 (32%), Positives = 61/153 (39%), Gaps = 22/153 (14%)

Query: 366 PVSPAPQPTE--ERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAA------DYR 417
           PVS AP P    +  P  P+    A  +  +S   P      EPV+           DY 
Sbjct: 330 PVSLAPPPPSILQVTPQLPLMGFVARVQENISDTPPPPPPVEEPVFDESPPPPPPPEDYE 389

Query: 418 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 477
           E         A    Y    A    P    +Y E         VA+YDY    +DE+SF 
Sbjct: 390 EEE-------AAVVEYSDPYAEEDPPWAPRSYLE-------KVVAIYDYTKDKEDELSFQ 435

Query: 478 PDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
              II  I+  DDGW+ GV  G  GLFP NYVE
Sbjct: 436 EGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVE 468


>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
          Length = 1014

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)

Query: 418  EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 477
            + S  QG  Y  +    S  +  H P    TY            A+YDY A  +DE+SF 
Sbjct: 929  QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 976

Query: 478  PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 510
              D I N++ IDDGW  G  +  GR G+ PANY+E
Sbjct: 977  DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011


>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
          Length = 270

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)

Query: 418 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 477
           + S  QG  Y  +    S  +  H P    TY            A+YDY A  +DE+SF 
Sbjct: 185 QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 232

Query: 478 PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 510
             D I N++ IDDGW  G  +  GR G+ PANY+E
Sbjct: 233 DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 267


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 23/51 (45%), Positives = 33/51 (64%)

Query: 461  VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 511
            + +YDY A  DDE++F+   II  +   D  WW+G   G+ GLFP+NYV+L
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 59/208 (28%), Positives = 86/208 (41%), Gaps = 22/208 (10%)

Query: 317 FENLAKE------KEQEDRRKA-EAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP 369
           F N  KE      K+Q  ++K+ EAER ++  +ER+  E  ++K E Q RA+ +      
Sbjct: 603 FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLE 662

Query: 370 APQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYAT 429
             Q  +E      ++E+      +L     V   + E     EA D       Q    A 
Sbjct: 663 HVQQEDEHQRPRKLHEEE-----KLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717

Query: 430 EAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDII-TNIEMI 488
            AV          P    T    EN   +   ALY +++   DEI+  P DI+    E +
Sbjct: 718 PAVQAPWSTAEKGPL---TISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774

Query: 489 DD------GWWRGVCKGRYGLFPANYVE 510
           D+      GW  G  KG+ G FPANY E
Sbjct: 775 DESQTGEPGWLGGELKGKTGWFPANYAE 802



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 3/81 (3%)

Query: 431 AVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDD 490
           + +  A A G  P+      + E   G+ A ALY ++A  D+ ++F+ +D+IT +E   D
Sbjct: 891 SAFTPATATGSSPSP--VLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QD 947

Query: 491 GWWRGVCKGRYGLFPANYVEL 511
            WW G  +G+ G FP +YV+L
Sbjct: 948 MWWFGEVQGQKGWFPKSYVKL 968



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 1/52 (1%)

Query: 461  VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELR 512
            +A+Y Y+++   +++F   D+I  +   D  WW G    + G+FP+NYV L+
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPSNYVRLK 1058



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)

Query: 385  EDAASFK--AELSYRGPVSGTEPEPVYSMEAADYREASSQQGLA---------YATEAVY 433
            E  AS K  A  + +  VSG E   +Y+ E+++  + + QQG           + T  V 
Sbjct: 985  ESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVG 1044

Query: 434  ESAEA-PGHY----PAEDSTYDEYENDLGIT---AVALYDYQAAGDDEISFDPDDIITNI 485
            + A   P +Y     +E S        LG     A  +  Y A G ++++  P  +I   
Sbjct: 1045 DKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIR 1104

Query: 486  EMIDDGWWRGVCKGR-----YGLFPANYVEL 511
            +    GWW G  + R      G FPANYV+L
Sbjct: 1105 KKNPGGWWEGELQARGKKRQIGWFPANYVKL 1135



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 8/74 (10%)

Query: 298 QKTVPVEAVTSKTSNI-RANFE------NLAKEKEQEDRRKAEAERAQRMAKERQEQE-E 349
           +K +PV     K  N  R N E       L +++ +E  R A+ ERA++  KER+ QE E
Sbjct: 343 EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQE 402

Query: 350 ARRKLEEQARAKTQ 363
            +R+LE + + + Q
Sbjct: 403 RKRQLELEKQLEKQ 416



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 5/51 (9%)

Query: 318 ENLAKEKE-QEDRRKAEAERAQRMAK----ERQEQEEARRKLEEQARAKTQ 363
           E   KE+E QE  RK + E  +++ K    ERQ +EE R+++E +  AK +
Sbjct: 390 EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRE 440



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 15/38 (39%), Positives = 24/38 (63%)

Query: 320 LAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQ 357
           L  EK+ E +R+ E +R +   KE + +E A+R+LE Q
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQ 444


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 23/51 (45%), Positives = 33/51 (64%)

Query: 461  VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 511
            + +YDY A  DDE++F+   II  +   D  WW+G   G+ GLFP+NYV+L
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 59/208 (28%), Positives = 86/208 (41%), Gaps = 22/208 (10%)

Query: 317 FENLAKE------KEQEDRRKA-EAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP 369
           F N  KE      K+Q  ++K+ EAER ++  +ER+  E  ++K E Q RA+ +      
Sbjct: 603 FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLE 662

Query: 370 APQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYAT 429
             Q  +E      ++E+      +L     V   + E     EA D       Q    A 
Sbjct: 663 HVQQEDEHQRPRKLHEEE-----KLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717

Query: 430 EAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDII-TNIEMI 488
            AV          P    T    EN   +   ALY +++   DEI+  P DI+    E +
Sbjct: 718 PAVQAPWSTAEKGPL---TISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774

Query: 489 DD------GWWRGVCKGRYGLFPANYVE 510
           D+      GW  G  KG+ G FPANY E
Sbjct: 775 DESQTGEPGWLGGELKGKTGWFPANYAE 802



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 3/81 (3%)

Query: 431 AVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDD 490
           + +  A A G  P+      + E   G+ A ALY ++A  D+ ++F+ +D+IT +E   D
Sbjct: 891 SAFTPATATGSSPSP--VLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QD 947

Query: 491 GWWRGVCKGRYGLFPANYVEL 511
            WW G  +G+ G FP +YV+L
Sbjct: 948 MWWFGEVQGQKGWFPKSYVKL 968



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 1/52 (1%)

Query: 461  VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELR 512
            +A+Y Y+++   +++F   D+I  +   D  WW G    + G+FP+NYV L+
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPSNYVRLK 1058



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)

Query: 385  EDAASFK--AELSYRGPVSGTEPEPVYSMEAADYREASSQQGLA---------YATEAVY 433
            E  AS K  A  + +  VSG E   +Y+ E+++  + + QQG           + T  V 
Sbjct: 985  ESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVG 1044

Query: 434  ESAEA-PGHY----PAEDSTYDEYENDLGIT---AVALYDYQAAGDDEISFDPDDIITNI 485
            + A   P +Y     +E S        LG     A  +  Y A G ++++  P  +I   
Sbjct: 1045 DKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIR 1104

Query: 486  EMIDDGWWRGVCKGR-----YGLFPANYVEL 511
            +    GWW G  + R      G FPANYV+L
Sbjct: 1105 KKNPGGWWEGELQARGKKRQIGWFPANYVKL 1135



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 8/74 (10%)

Query: 298 QKTVPVEAVTSKTSNI-RANFE------NLAKEKEQEDRRKAEAERAQRMAKERQEQE-E 349
           +K +PV     K  N  R N E       L +++ +E  R A+ ERA++  KER+ QE E
Sbjct: 343 EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQE 402

Query: 350 ARRKLEEQARAKTQ 363
            +R+LE + + + Q
Sbjct: 403 RKRQLELEKQLEKQ 416



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 5/51 (9%)

Query: 318 ENLAKEKE-QEDRRKAEAERAQRMAK----ERQEQEEARRKLEEQARAKTQ 363
           E   KE+E QE  RK + E  +++ K    ERQ +EE R+++E +  AK +
Sbjct: 390 EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRE 440



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 15/38 (39%), Positives = 24/38 (63%)

Query: 320 LAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQ 357
           L  EK+ E +R+ E +R +   KE + +E A+R+LE Q
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQ 444


>gi|61743948 abl-interactor 1 isoform d [Homo sapiens]
          Length = 476

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/50 (56%), Positives = 32/50 (64%)

Query: 461 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
           VA+YDY    DDE+SF    II  I+  DDGW+ GVC    GLFP NYVE
Sbjct: 420 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 469


>gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
          Length = 452

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/50 (56%), Positives = 32/50 (64%)

Query: 461 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
           VA+YDY    DDE+SF    II  I+  DDGW+ GVC    GLFP NYVE
Sbjct: 396 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445


>gi|61743944 abl-interactor 1 isoform b [Homo sapiens]
          Length = 481

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/50 (56%), Positives = 32/50 (64%)

Query: 461 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
           VA+YDY    DDE+SF    II  I+  DDGW+ GVC    GLFP NYVE
Sbjct: 425 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474


>gi|61743942 abl-interactor 1 isoform a [Homo sapiens]
          Length = 508

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/50 (56%), Positives = 32/50 (64%)

Query: 461 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
           VA+YDY    DDE+SF    II  I+  DDGW+ GVC    GLFP NYVE
Sbjct: 452 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 501


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 2/69 (2%)

Query: 443 PAEDSTYDEYEN--DLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGR 500
           PA+DS  D  E   DL + A   ++Y A  +DE+S      +  +E   DGWWRG   G+
Sbjct: 92  PADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQ 151

Query: 501 YGLFPANYV 509
            G FP+NYV
Sbjct: 152 VGWFPSNYV 160



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 7/57 (12%)

Query: 462 ALYDYQAAGDDEISFDPDDIITNIEM--IDDGWWRGVCK---GRYGLFPANYVELRQ 513
           ALY + ++ D+E++F+  D++  IE    D  WW+  C+   G  GL P NYV + Q
Sbjct: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWK--CRKINGMVGLVPKNYVTVMQ 251



 Score = 29.6 bits (65), Expect = 6.9
 Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 6/56 (10%)

Query: 458 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 510
           +  VA +DY A  + E+    ++    + ++DD   WWR      + G  P+NYVE
Sbjct: 5   VVVVAKFDYVAQQEQELDIKKNE---RLWLLDDSKSWWRVRNSMNKTGFVPSNYVE 57


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 59/239 (24%), Positives = 103/239 (43%), Gaps = 21/239 (8%)

Query: 287  FEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKE--------QEDRRKAEAERAQ 338
            F DV    +  ++  P+ A T++  ++    +NL K+ +         E R KA  ++  
Sbjct: 790  FRDVEDEETWIREKEPIAASTNRGKDL-IGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848

Query: 339  RMAKERQ-EQEEARRKLEE-QARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSY 396
             M +E     E+ + KL E   + +      S   Q  E+ L +   + DA   ++ +  
Sbjct: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908

Query: 397  RGPVSGTEP--EPVYSMEAADYREASSQQGL-AYAT--EAVYESAEAPGHYPAEDSTYDE 451
            + P+ G+    +   S EA   +  +    L AY +  +A+ E A++     A   T DE
Sbjct: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966

Query: 452  YENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
               +L    +ALYDYQ     E++    DI+T +   +  WW+     R G  PA YV+
Sbjct: 967  TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK 1022


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 59/239 (24%), Positives = 103/239 (43%), Gaps = 21/239 (8%)

Query: 287  FEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKE--------QEDRRKAEAERAQ 338
            F DV    +  ++  P+ A T++  ++    +NL K+ +         E R KA  ++  
Sbjct: 790  FRDVEDEETWIREKEPIAASTNRGKDL-IGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848

Query: 339  RMAKERQ-EQEEARRKLEE-QARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSY 396
             M +E     E+ + KL E   + +      S   Q  E+ L +   + DA   ++ +  
Sbjct: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908

Query: 397  RGPVSGTEP--EPVYSMEAADYREASSQQGL-AYAT--EAVYESAEAPGHYPAEDSTYDE 451
            + P+ G+    +   S EA   +  +    L AY +  +A+ E A++     A   T DE
Sbjct: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966

Query: 452  YENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 510
               +L    +ALYDYQ     E++    DI+T +   +  WW+     R G  PA YV+
Sbjct: 967  TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK 1022


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/68 (42%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
           YPA  S  D    DL I A   + Y A  +DE+S      +T +E   DGWWRG   G+ 
Sbjct: 99  YPANGSGADRIY-DLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQI 157

Query: 502 GLFPANYV 509
           G FP+NYV
Sbjct: 158 GWFPSNYV 165



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 7/52 (13%)

Query: 463 LYDYQAAGDDEISFDPDDIITNIEMI--DDGWWRGVCK---GRYGLFPANYV 509
           LY + +  ++E++F+  + +  IE    D  WW+  CK   G+ GL P NYV
Sbjct: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWK--CKNARGQVGLVPKNYV 252



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 6/56 (10%)

Query: 458 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 510
           +  +A +DY A  D E+    ++    + ++DD   WWR      R G  P+NYVE
Sbjct: 5   VIVIAKWDYTAQQDQELDIKKNE---RLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57


>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/68 (42%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
           YPA  S  D    DL I A   + Y A  +DE+S      +T +E   DGWWRG   G+ 
Sbjct: 99  YPANGSGADRIY-DLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQI 157

Query: 502 GLFPANYV 509
           G FP+NYV
Sbjct: 158 GWFPSNYV 165



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 7/52 (13%)

Query: 463 LYDYQAAGDDEISFDPDDIITNIEMI--DDGWWRGVCK---GRYGLFPANYV 509
           LY + +  ++E++F+  + +  IE    D  WW+  CK   G+ GL P NYV
Sbjct: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWK--CKNARGQVGLVPKNYV 252



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 6/56 (10%)

Query: 458 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 510
           +  +A +DY A  D E+    ++    + ++DD   WWR      R G  P+NYVE
Sbjct: 5   VIVIAKWDYTAQQDQELDIKKNE---RLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57


>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
          Length = 540

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 1/68 (1%)

Query: 442 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 501
           YP+  S    ++++ G    A+YD++AA D+E++F   +IIT ++  D  WW+G      
Sbjct: 198 YPSTSSLLTNHQHE-GRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGI 256

Query: 502 GLFPANYV 509
           GLFP+N+V
Sbjct: 257 GLFPSNFV 264


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 7/94 (7%)

Query: 423 QGLAYATEAVYESAE-APGHYPAEDSTYDEYENDLGITA-VALYDYQAAGDDEISFDPDD 480
           +G A AT+    SA  APG   +  ST        G     ALYDY+A G+DE+S     
Sbjct: 4   RGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQ 63

Query: 481 IITNIEMI-----DDGWWRGVCKGRYGLFPANYV 509
           ++  +        D+GWW G  + R G+FPANYV
Sbjct: 64  LVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYV 97



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 17/75 (22%), Positives = 35/75 (46%), Gaps = 1/75 (1%)

Query: 284 ASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE-KEQEDRRKAEAERAQRMAK 342
           A   E +T +  A    +P E+  S   + +   + +  E + +E   ++  E   R A 
Sbjct: 392 ALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAAL 451

Query: 343 ERQEQEEARRKLEEQ 357
           +++ QEE  ++ E+Q
Sbjct: 452 QQKSQEELLKRREQQ 466


>gi|55956916 myosin IE [Homo sapiens]
          Length = 1108

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 25/48 (52%), Positives = 31/48 (64%)

Query: 462  ALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYV 509
            ALY Y A   DE+SF+ +DII  I+    GWW G  +G+ GLFP NYV
Sbjct: 1058 ALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYV 1105


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,070,619
Number of Sequences: 37866
Number of extensions: 992691
Number of successful extensions: 12579
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 416
Number of HSP's successfully gapped in prelim test: 557
Number of HSP's that attempted gapping in prelim test: 6857
Number of HSP's gapped (non-prelim): 4163
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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