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Search of human proteins with 20127452
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
(490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 996 0.0
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 760 0.0
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 577 e-165
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 577 e-165
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 577 e-165
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 225 8e-59
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 223 2e-58
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 223 2e-58
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 223 2e-58
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 219 3e-57
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 219 3e-57
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 181 1e-45
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 181 1e-45
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 176 3e-44
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 166 4e-41
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 157 3e-38
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 156 5e-38
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 152 9e-37
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 151 1e-36
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 151 1e-36
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 148 1e-35
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 148 1e-35
gi|11415052 retinoid X receptor, beta [Homo sapiens] 144 2e-34
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 142 5e-34
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 139 6e-33
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 139 6e-33
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 139 6e-33
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 139 6e-33
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 139 6e-33
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 137 2e-32
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 996 bits (2575), Expect = 0.0
Identities = 490/490 (100%), Positives = 490/490 (100%)
Query: 1 MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
Sbjct: 1 MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
Query: 61 TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
Sbjct: 61 TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
Query: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
Sbjct: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
Query: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
Sbjct: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
Query: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
Sbjct: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
Query: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
Sbjct: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
Query: 361 PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 420
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
Sbjct: 361 PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 420
Query: 421 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC 480
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
Sbjct: 421 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC 480
Query: 481 EDLAGNAASP 490
EDLAGNAASP
Sbjct: 481 EDLAGNAASP 490
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 760 bits (1962), Expect = 0.0
Identities = 370/375 (98%), Positives = 373/375 (99%)
Query: 1 MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
Sbjct: 1 MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
Query: 61 TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
Sbjct: 61 TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
Query: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
Sbjct: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
Query: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
Sbjct: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
Query: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
Sbjct: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
Query: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
Sbjct: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
Query: 361 PHFWPKLLMKEREVQ 375
PHFWPKLLMK +++
Sbjct: 361 PHFWPKLLMKVTDLR 375
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 577 bits (1487), Expect = e-165
Identities = 273/335 (81%), Positives = 308/335 (91%)
Query: 41 GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+ CVID
Sbjct: 95 GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+ +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
T EEW+LI TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
Q+++LLAFEHY+N+RKH++ HFWPKLLMK +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 577 bits (1487), Expect = e-165
Identities = 273/335 (81%), Positives = 308/335 (91%)
Query: 41 GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+ CVID
Sbjct: 95 GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+ +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
T EEW+LI TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
Q+++LLAFEHY+N+RKH++ HFWPKLLMK +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 577 bits (1487), Expect = e-165
Identities = 273/335 (81%), Positives = 308/335 (91%)
Query: 41 GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+ CVID
Sbjct: 95 GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+ +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
T EEW+LI TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
Q+++LLAFEHY+N+RKH++ HFWPKLLMK +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 225 bits (573), Expect = 8e-59
Identities = 127/331 (38%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D CVI+K+TRN+CQ CR
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--IYTCHRDKNCVINKVTRNRCQYCRL 138
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE + + E T E DL
Sbjct: 139 QKCFEVGMSKESVRND-------------RNKKKKETSKQECTESYEMTAELDDLTEKIR 185
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 186 KAHQETFPSLC---QLGKYTTNSSADHRV-------RLDLGLWDKFSELATKCIIKIVEF 235
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DDTE LL A+ L+ DR L K++K QE L A + Y
Sbjct: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
+ R+ + PH +PK+LMK +++ SI KGA
Sbjct: 356 IRKRRPSKPHMFPKILMKITDLR-SISAKGA 385
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 223 bits (569), Expect = 2e-58
Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
V R+ + PH +PK+LMK +++ SI KGA
Sbjct: 363 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 392
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 223 bits (569), Expect = 2e-58
Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 83 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 140
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 141 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 187
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 188 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 237
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
V R+ + PH +PK+LMK +++ SI KGA
Sbjct: 358 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 387
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 223 bits (569), Expect = 2e-58
Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE + TPE +LI
Sbjct: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ ++ + + +D++ + +F+++ T I + V+F
Sbjct: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DD E LL A+ L+ DR L D+++ QE L A + Y
Sbjct: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
V R+ + PH +PK+LMK +++ SI KGA
Sbjct: 363 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 392
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 219 bits (559), Expect = 3e-57
Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 136
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 137 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 183
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 184 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 233
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 234 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 293
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 294 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 353
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
R+ + P+ +P++LMK +++ I KGA
Sbjct: 354 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 383
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 219 bits (559), Expect = 3e-57
Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 195 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 244
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
R+ + P+ +P++LMK +++ I KGA
Sbjct: 365 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 394
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 181 bits (459), Expect = 1e-45
Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)
Query: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 50 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 107
Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 108 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 166
Query: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 167 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 219
Query: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 220 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 279
Query: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 280 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 339
Query: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
Y+ A YV+ H H+ F P++LMK
Sbjct: 340 YVEALHAYVSIHHPHDRLMF-PRMLMK 365
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 181 bits (459), Expect = 1e-45
Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)
Query: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
+E C VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C C +D R +CQ
Sbjct: 95 NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 152
Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
CR +KC GM + VL + +++ +KL Q E+ + Q P+ +PE+
Sbjct: 153 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 211
Query: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
+I A + N + + R + P P+ P + + F+ FT++ +
Sbjct: 212 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 264
Query: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
+ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P S+++T + + RE
Sbjct: 265 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 324
Query: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
GL V + IFE ++++ L+D E ALL A+ + S DR + ++E+ Q
Sbjct: 325 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 384
Query: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
Y+ A YV+ H H+ F P++LMK
Sbjct: 385 YVEALHAYVSIHHPHDRLMF-PRMLMK 410
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 176 bits (447), Expect = 3e-44
Identities = 104/295 (35%), Positives = 158/295 (53%), Gaps = 24/295 (8%)
Query: 89 YSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKE 148
Y+C D CVI+K+TRN+CQ CR +KC VGM+ + V +D R +++KE
Sbjct: 3 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND-------------RNKKKKE 49
Query: 149 EMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD 208
+ + E T E DL +AH+ T Q K+ + +
Sbjct: 50 TSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNSSADHRV------- 99
Query: 209 KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD 268
++DL + +F+++ T I ++V+FAK+LP F+ L DQI LLK C++I+ LR RY
Sbjct: 100 RLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT 159
Query: 269 PESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTD 328
PE DT+T S + + R Q+ N G G ++D +F L +DDTE LL A+ L+ D
Sbjct: 160 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGD 219
Query: 329 RSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
R L K++K QE L A + Y+ R+ + PH +PK+LMK +++ SI KGA
Sbjct: 220 RQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLR-SISAKGA 273
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 166 bits (420), Expect = 4e-41
Identities = 109/329 (33%), Positives = 167/329 (50%), Gaps = 37/329 (11%)
Query: 50 DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
DE CVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK CV+D R +CQ
Sbjct: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNA--VYKCKNGGNCVMDMYMRRKCQE 181
Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKR--KLIEQN-----------RERRRKEEMIRSLQQ 156
CR +KC +GM + +L + + +KR K ++Q+ R+ R+ +S ++
Sbjct: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
Query: 157 RPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFS 216
+ E TP++ L+H +++ N Q + K L ++ E F
Sbjct: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
Query: 217 EFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL 276
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
Query: 277 SGEMAVKREQLKNGGLG-VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCV 335
SG + E+++N G+ +F KS+ + E ALL A++++S DR +
Sbjct: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
Query: 336 DKIEKSQEAYLLAFEHYVN-HRKHNIPHF 363
+ +EK QE L + H+ N HF
Sbjct: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHF 430
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 157 bits (396), Expect = 3e-38
Identities = 100/342 (29%), Positives = 172/342 (50%), Gaps = 35/342 (10%)
Query: 30 NGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTY 89
NG + SG + S+ C +CGD+++G HY +CEGCKGFF+RT++K+L TY
Sbjct: 114 NGVLKVPAHPSGNMASFTK--HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL--TY 169
Query: 90 SCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEE 149
+C+ + C+IDK RN+CQ CR++KC+A+GM + V + E+ R + R E
Sbjct: 170 TCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQE-----------ERQRGKDRNEN 218
Query: 150 MIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDK 209
+ S E P E R A+ + + ++ ++G +P S P+
Sbjct: 219 EVESTSSANEDMPVE-----------RILEAELAVEPKTETYVEANMGLNP--SSPN--- 262
Query: 210 VDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDP 269
+ + + + +V++AK++P FSELP +DQ+ILL+ E++ + R
Sbjct: 263 ---DPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIA 319
Query: 270 ESDTLTLSGEMAVKREQLKNGGLGVVSDAIF-ELGKSLSAFNLDDTEVALLQAVLLMSTD 328
D + L+ + V R + G+G + D + EL + +D TE+ L+A++L + D
Sbjct: 320 VKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPD 379
Query: 329 RSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMK 370
GL ++E +E + E Y H+ P + KLL++
Sbjct: 380 SKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLR 421
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 156 bits (394), Expect = 5e-38
Identities = 109/335 (32%), Positives = 161/335 (48%), Gaps = 25/335 (7%)
Query: 48 DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
D+ CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ PT C + C + K R C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
CR +KC+ GM D++L E RR K+ R+ Q + + E+ +L
Sbjct: 64 PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
I AH T G+ ++Q +F P I P+ ++ L + F I T
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
+ +V+ F K LP+F LP EDQI LLKG +EI + + ++ L G +
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTI 226
Query: 285 EQLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQE 343
E G V + +F +L L + E LL A+ L S DR G+ D+I++ QE
Sbjct: 227 EDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQE 286
Query: 344 AYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
L + Y+ R+ + KLL E++S
Sbjct: 287 EMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 321
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 152 bits (383), Expect = 9e-37
Identities = 110/342 (32%), Positives = 165/342 (48%), Gaps = 35/342 (10%)
Query: 48 DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
D+ CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ PT C + C + K R C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
CR +KC+ GM D++L E RR K+ R+ Q + + E+ +L
Sbjct: 64 PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
I AH T G+ ++Q +F P I P+ ++ L + F I T
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
+ +V+ F K LP+F LP EDQI LLKG +EI + + ++ L G + R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223
Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVD 336
+++G G V + +F +L L + E LL A+ L S DR G+ D
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRD 283
Query: 337 KIEKSQEAYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
+I++ QE L + Y+ R+ + KLL E++S
Sbjct: 284 EIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 325
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 151 bits (382), Expect = 1e-36
Identities = 104/315 (33%), Positives = 152/315 (48%), Gaps = 28/315 (8%)
Query: 48 DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
D+ CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ PT C + C + K R C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
CR +KC+ GM D++L E RR K+ R+ Q + + E+ +L
Sbjct: 64 PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
I AH T G+ ++Q +F P I P+ ++ L + F I T
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
+ +V+ F K LP+F LP EDQI LLKG +EI + + ++ L G +
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTI 226
Query: 285 EQLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMS-----TDRSGLLCVDKI 338
E G V + +F +L L + E LL A+ L S TDR G+ D+I
Sbjct: 227 EDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEI 286
Query: 339 EKSQEAYLLAFEHYV 353
++ QE L + Y+
Sbjct: 287 DQLQEEMALTLQSYI 301
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 151 bits (381), Expect = 1e-36
Identities = 104/317 (32%), Positives = 155/317 (48%), Gaps = 33/317 (10%)
Query: 48 DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
D+ CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ PT C + C + K R C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
CR +KC+ GM D++L E RR K+ R+ Q + + E+ +L
Sbjct: 64 PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
I AH T G+ ++Q +F P I P+ ++ L + F I T
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
+ +V+ F K LP+F LP EDQI LLKG +EI + + ++ L G + R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223
Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVD 336
+++G G V + +F +L L + E LL A+ L S DR G+ D
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRD 283
Query: 337 KIEKSQEAYLLAFEHYV 353
+I++ QE L + Y+
Sbjct: 284 EIDQLQEEMALTLQSYI 300
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 148 bits (373), Expect = 1e-35
Identities = 104/326 (31%), Positives = 158/326 (48%), Gaps = 26/326 (7%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD A HY TCEGCKGFF+RT+QKN Y C + C +DK RN+CQ CRF
Sbjct: 263 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 320
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
+KC+AVGM ++V DS + + +L + + Q P P LI
Sbjct: 321 QKCLAVGMVKEVVRTDSLKGRRGRLPSKPKS-----------PQEPSPPSPPVSLISALV 369
Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
AH +N + R D S GD D + +F ++T ++ + +
Sbjct: 370 RAHVDSNPAMTSLDYSRFQANPDYQMS-------GD--DTQHIQQFYDLLTGSMEIIRGW 420
Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
A+K+P F++LP DQ +L + +E+ LR A R +P L + + R Q G
Sbjct: 421 AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-GF 479
Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
G D+I E +L N+D + + + A L M T+R GL ++E+ Q + + +
Sbjct: 480 GEWIDSIVEFSSNLQNMNIDISAFSCI-AALAMVTERHGLKEPKRVEELQNKIVNCLKDH 538
Query: 353 V--NHRKHNIPHFWPKLLMKEREVQS 376
V N+ N P++ KLL K E+++
Sbjct: 539 VTFNNGGLNRPNYLSKLLGKLPELRT 564
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 148 bits (373), Expect = 1e-35
Identities = 111/347 (31%), Positives = 166/347 (47%), Gaps = 40/347 (11%)
Query: 48 DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
D+ CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ PT C + C + K R C
Sbjct: 6 DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63
Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
CR +KC+ GM D++L E RR K+ R+ Q + + E+ +L
Sbjct: 64 PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113
Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
I AH T G+ ++Q +F P I P+ ++ L + F I T
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
+ +V+ F K LP+F LP EDQI LLKG +EI + + ++ L G + R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223
Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMS-----TDRSG 331
+++G G V + +F +L L + E LL A+ L S TDR G
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPG 283
Query: 332 LLCVDKIEKSQEAYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
+ D+I++ QE L + Y+ R+ + KLL E++S
Sbjct: 284 VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 330
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 144 bits (363), Expect = 2e-34
Identities = 95/321 (29%), Positives = 159/321 (49%), Gaps = 36/321 (11%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C +CGD+++G HY +CEGCKGFF+RTI+K+L TYSC+ + C +DK RN+CQ CR+
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDL--TYSCRDNKDCTVDKRQRNRCQYCRY 262
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRER-RRKEEMIRSLQQRPEPTPEEWDL-IHI 170
+KC+A GM KR+ +++ R+R + K+ PE P + L +
Sbjct: 263 QKCLATGM-------------KREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAEL 309
Query: 171 ATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVV 230
A E +G P+D P+ ++ D + F+ +V
Sbjct: 310 AVEQKSDQGVEGPGGTGGSGSSPND----PVTNICQA--ADKQLFT------------LV 351
Query: 231 DFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNG 290
++AK++P FS LP +DQ+ILL+ E++ + R D + L+ + V R +
Sbjct: 352 EWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSA 411
Query: 291 GLGVVSDAIF-ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAF 349
G+G + D + EL + +D TE+ L+A++L + D GL ++E +E +
Sbjct: 412 GVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASL 471
Query: 350 EHYVNHRKHNIPHFWPKLLMK 370
E Y + + KLL++
Sbjct: 472 ETYCKQKYPEQQGRFAKLLLR 492
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 142 bits (359), Expect = 5e-34
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 17/318 (5%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKY-DSCCVIDKITRNQCQLCR 111
C VCGDKATGYH+ +TCEGCKGFFRR +++N C + C I + TR QCQ CR
Sbjct: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQACR 98
Query: 112 FKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEM--IRSLQQRPEPTPEEWDLIH 169
+KC+ GM ++++ D +R LI++ + R + ++ L T E+ +I
Sbjct: 99 LRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGL------TEEQRMMIR 152
Query: 170 IATEAHRST-NAQGSHWKQRRKFLPDDIGQSPIVS-MPDGDKVDLEAFS---EFTKIITP 224
+A T + SH+K R L + + P D E FS + T
Sbjct: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE-CGRLSYCL 271
Query: 285 EQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
E G ++ + + + L L + E L+QA+ L S DR G+L +++ QE
Sbjct: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
Query: 345 YLLAFEHYVNHRKHNIPH 362
+ + + Y+ + H
Sbjct: 332 FAITLKSYIECNRPQPAH 349
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 139 bits (350), Expect = 6e-33
Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C ++ C I K R CQ CR
Sbjct: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
K+C+ +GM + +L D + KR++I +RKEE RP+ + E+ +I I
Sbjct: 82 KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
Query: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
+AH T + GSH + F D + D
Sbjct: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
Query: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
+D +FS +++ +I +V+ FAK +P F +L
Sbjct: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
Query: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
EDQI+LLK +E++ LR+ + + + T + R + K G + + + +
Sbjct: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
Query: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
L NL + E LL A+ ++S DR G+ IE Q+ + Y+ R H P
Sbjct: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
Query: 363 ---FWPKLLMKEREVQS 376
+ K++ K +++S
Sbjct: 376 SHLLYAKMIQKLADLRS 392
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 139 bits (350), Expect = 6e-33
Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C ++ C I K R CQ CR
Sbjct: 24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
K+C+ +GM + +L D + KR++I +RKEE RP+ + E+ +I I
Sbjct: 82 KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136
Query: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
+AH T + GSH + F D + D
Sbjct: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196
Query: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
+D +FS +++ +I +V+ FAK +P F +L
Sbjct: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256
Query: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
EDQI+LLK +E++ LR+ + + + T + R + K G + + + +
Sbjct: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316
Query: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
L NL + E LL A+ ++S DR G+ IE Q+ + Y+ R H P
Sbjct: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375
Query: 363 ---FWPKLLMKEREVQS 376
+ K++ K +++S
Sbjct: 376 SHLLYAKMIQKLADLRS 392
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 139 bits (350), Expect = 6e-33
Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD A HY TCEGCKGFF+RT+QKN Y C + C +DK RN+CQ CRF
Sbjct: 303 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 360
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
+KC++VGM ++V DS + R R + LQQ P +P+P + +
Sbjct: 361 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 411
Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
T++ R + P D + D E +F ++T +I
Sbjct: 412 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 461
Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
+A+K+P F++LP EDQ +L++ +E+ LR ++R + D + + R Q G
Sbjct: 462 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 520
Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
G D+I + +L + NLD +A L A L M T+R GL ++E+
Sbjct: 521 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 568
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 139 bits (350), Expect = 6e-33
Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD A HY TCEGCKGFF+RT+QKN Y C + C +DK RN+CQ CRF
Sbjct: 292 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 349
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
+KC++VGM ++V DS + R R + LQQ P +P+P + +
Sbjct: 350 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 400
Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
T++ R + P D + D E +F ++T +I
Sbjct: 401 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 450
Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
+A+K+P F++LP EDQ +L++ +E+ LR ++R + D + + R Q G
Sbjct: 451 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 509
Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
G D+I + +L + NLD +A L A L M T+R GL ++E+
Sbjct: 510 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 557
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 139 bits (350), Expect = 6e-33
Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)
Query: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
C VCGD A HY TCEGCKGFF+RT+QKN Y C + C +DK RN+CQ CRF
Sbjct: 292 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 349
Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
+KC++VGM ++V DS + R R + LQQ P +P+P + +
Sbjct: 350 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 400
Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
T++ R + P D + D E +F ++T +I
Sbjct: 401 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 450
Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
+A+K+P F++LP EDQ +L++ +E+ LR ++R + D + + R Q G
Sbjct: 451 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 509
Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
G D+I + +L + NLD +A L A L M T+R GL ++E+
Sbjct: 510 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 557
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 137 bits (346), Expect = 2e-32
Identities = 81/246 (32%), Positives = 131/246 (53%), Gaps = 11/246 (4%)
Query: 138 IEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIG 197
+ +R +++KE + TPE +LI +AH+ T Q K+ ++
Sbjct: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
Query: 198 QSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME 257
+ + +D++ + +F+++ T I + V+FAK+LP F+ L DQI LLK C++
Sbjct: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
Query: 258 IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVA 317
I+ LR RY PE DT+T S + + R Q+ N G G ++D +F L +DD E
Sbjct: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
Query: 318 LLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSS 377
LL A+ L+ DR L D+++ QE L A + YV R+ + PH +PK+LMK +++ S
Sbjct: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR-S 289
Query: 378 ILYKGA 383
I KGA
Sbjct: 290 ISAKGA 295
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,240,243
Number of Sequences: 37866
Number of extensions: 977556
Number of successful extensions: 4254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3856
Number of HSP's gapped (non-prelim): 219
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.