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Search of human proteins with 194473700
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194473700 Src homology 3 domain-containing guanine
nucleotide exchange factor [Homo sapiens]
(871 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 1724 0.0
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 511 e-144
gi|166197690 neuronal guanine nucleotide exchange factor isoform... 317 4e-86
gi|166197688 neuronal guanine nucleotide exchange factor isoform... 317 4e-86
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens] 288 2e-77
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom... 266 5e-71
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens] 242 1e-63
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 115 2e-25
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 112 1e-24
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 112 1e-24
gi|38373682 pleckstrin homology domain containing family G membe... 99 2e-20
gi|111154084 pleckstrin homology domain containing family G memb... 99 2e-20
gi|111154088 pleckstrin homology domain containing family G memb... 99 2e-20
gi|111154080 pleckstrin homology domain containing family G memb... 99 2e-20
gi|111154078 pleckstrin homology domain containing family G memb... 99 2e-20
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 87 5e-17
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 86 1e-16
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 84 7e-16
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 82 2e-15
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 80 6e-15
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 79 2e-14
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 79 2e-14
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 79 2e-14
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 77 9e-14
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 75 3e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 75 3e-13
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 75 3e-13
gi|222080070 pleckstrin homology domain-containing family G memb... 74 6e-13
gi|222080068 pleckstrin homology domain-containing family G memb... 74 6e-13
gi|222080066 pleckstrin homology domain-containing family G memb... 74 6e-13
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 1724 bits (4465), Expect = 0.0
Identities = 871/871 (100%), Positives = 871/871 (100%)
Query: 1 MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLL 60
MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLL
Sbjct: 1 MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLL 60
Query: 61 AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV 120
AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV
Sbjct: 61 AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV 120
Query: 121 PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA 180
PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA
Sbjct: 121 PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA 180
Query: 181 NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP 240
NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP
Sbjct: 181 NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP 240
Query: 241 AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN 300
AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN
Sbjct: 241 AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN 300
Query: 301 DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI 360
DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI
Sbjct: 301 DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI 360
Query: 361 KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ 420
KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ
Sbjct: 361 KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ 420
Query: 421 LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER 480
LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER
Sbjct: 421 LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER 480
Query: 481 HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ 540
HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ
Sbjct: 481 HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ 540
Query: 541 RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS 600
RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS
Sbjct: 541 RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS 600
Query: 601 PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG 660
PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG
Sbjct: 601 PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG 660
Query: 661 ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE 720
ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE
Sbjct: 661 ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE 720
Query: 721 ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS 780
ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS
Sbjct: 721 ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS 780
Query: 781 SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF 840
SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF
Sbjct: 781 SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF 840
Query: 841 PMECAKEITCQATIDKNVERMGRLLGLETNV 871
PMECAKEITCQATIDKNVERMGRLLGLETNV
Sbjct: 841 PMECAKEITCQATIDKNVERMGRLLGLETNV 871
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 511 bits (1316), Expect = e-144
Identities = 313/676 (46%), Positives = 420/676 (62%), Gaps = 44/676 (6%)
Query: 216 PLQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRL 275
P R P E E +VLST SPAALK+G QQ+IPKSLA K +K+ ++ +
Sbjct: 58 PQPRPPGHE----EPWPIVLSTESPAALKLGTQQLIPKSLAVASK-AKTPARHQSFGAAV 112
Query: 276 LK---VRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTS 332
L R + L P + ++D D D G LRR LR+ SYR A+ P
Sbjct: 113 LSREAARRDPKLLPAP---SFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKG---LGKPGG 166
Query: 333 SKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQ-----GTFDGEENAVLYQNYKEKA 387
++S P L+ + E+ + + K K G+ G+F +++ LYQ +E+
Sbjct: 167 QGDAIQLS-PKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSF--KDDPQLYQEIQERG 223
Query: 388 LDIDS-------DEESEPK-EQKSDEKIVIH-HKPLRSTWSQLSAVKRKGLSQTVSQEER 438
L+ DE S P+ QK D IV+ ++P + TWSQL V G+ +S EER
Sbjct: 224 LNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEER 283
Query: 439 KRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFF 498
KRQEA+FE+++SE SY SL IL+ F SKEL T+T+ E HHLFSNI DV AS++FF
Sbjct: 284 KRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFF 343
Query: 499 IELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLS 558
+LE RH+ + ++DISDI+E+H F PY+ YC+NEVYQQRTLQKL+++N +F+E L
Sbjct: 344 EDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALR 403
Query: 559 RIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVR 618
IE C LPM+SFLILPMQRVTRLPLLMDT+C KT S +Y+ RALK +SKLVR
Sbjct: 404 EIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVR 463
Query: 619 LCNEGARKMERTEMMYTINSQLEF-KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTS 677
CNEGA +MER E MYT+++QL+F K+K PL+S+SRWL+KRGEL VE+T LF + S
Sbjct: 464 QCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGEL-FLVEETGLFRKIAS 522
Query: 678 KQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSR 737
+ Y FLFNDVL++TKKKSEESY V DY+ + + VE + EL G N R
Sbjct: 523 RPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLPGGGN-------R 575
Query: 738 QSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS--SGKPPADRTSLTQVE 795
SS H F +T+L N + ++LL +++ S+RARWI AL HS + + + L QVE
Sbjct: 576 SSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQGLSSKGDLPQVE 635
Query: 796 IVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQATID 855
I ++F AKQ DE++LQ ADVVL+ Q+ DGW GERLRDGE GWFP + A+ IT + ++
Sbjct: 636 ITKAFFAKQADEVTLQQADVVLVLQQ-EDGWLYGERLRDGETGWFPEDFARFITSRVAVE 694
Query: 856 KNVERMGRLLGLETNV 871
NV RM R L +ET+V
Sbjct: 695 GNVRRMER-LRVETDV 709
>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 618
Score = 317 bits (811), Expect = 4e-86
Identities = 187/557 (33%), Positives = 303/557 (54%), Gaps = 37/557 (6%)
Query: 328 DSPTSSKKKNRMSQPV-----------LKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEEN 376
DSPT+ + RM P+ + ++ ++ S+L I+ + + D
Sbjct: 56 DSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNG 115
Query: 377 AVLYQNYKEKALDIDSDEE-SEPKEQKSDEKIVIHHKPLR--STWSQLSAVKRKGLSQTV 433
+ ++ E+ + + +EE + P E+K+ +I + P + W L ++ G+ + +
Sbjct: 116 SPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEIL 175
Query: 434 SQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEA 493
EE K QEA+FE+++SE SY SL +L+ F ++ + + +E H LFSN+ DV
Sbjct: 176 QPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAV 235
Query: 494 SKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSF 553
S++F +ELE R + NI I D+ DIV ++ A F Y+ Y +N+ YQ+RT ++LL +F
Sbjct: 236 SERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAF 295
Query: 554 KEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEV 613
+E+++++E CR LP SFLILP QR+TRL LL+ I ++ + S + A KE+
Sbjct: 296 RELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKEL 355
Query: 614 SKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFS 673
+V+ CNEG RKM RTE M +I ++EFKIK P++S SRWL+K+GEL +
Sbjct: 356 EMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRT 415
Query: 674 RRTSK--QQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSS 731
RT K ++Y FLFND+L+I ++ + Y V D + R L VE +++
Sbjct: 416 LRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQ----------- 464
Query: 732 TMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTS- 790
+ +++F L +L N + + +L A +QSE RW+T+L + TS
Sbjct: 465 ------GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSR 518
Query: 791 ---LTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKE 847
QV+ V + A+QPDEL+L++AD++ I + DGW GERL D ERGWFP +E
Sbjct: 519 LLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEE 578
Query: 848 ITCQATIDKNVERMGRL 864
I +N++ R+
Sbjct: 579 ILNPKIRSQNLKECFRV 595
>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 710
Score = 317 bits (811), Expect = 4e-86
Identities = 187/557 (33%), Positives = 303/557 (54%), Gaps = 37/557 (6%)
Query: 328 DSPTSSKKKNRMSQPV-----------LKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEEN 376
DSPT+ + RM P+ + ++ ++ S+L I+ + + D
Sbjct: 148 DSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNG 207
Query: 377 AVLYQNYKEKALDIDSDEE-SEPKEQKSDEKIVIHHKPLR--STWSQLSAVKRKGLSQTV 433
+ ++ E+ + + +EE + P E+K+ +I + P + W L ++ G+ + +
Sbjct: 208 SPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEIL 267
Query: 434 SQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEA 493
EE K QEA+FE+++SE SY SL +L+ F ++ + + +E H LFSN+ DV
Sbjct: 268 QPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAV 327
Query: 494 SKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSF 553
S++F +ELE R + NI I D+ DIV ++ A F Y+ Y +N+ YQ+RT ++LL +F
Sbjct: 328 SERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAF 387
Query: 554 KEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEV 613
+E+++++E CR LP SFLILP QR+TRL LL+ I ++ + S + A KE+
Sbjct: 388 RELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKEL 447
Query: 614 SKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFS 673
+V+ CNEG RKM RTE M +I ++EFKIK P++S SRWL+K+GEL +
Sbjct: 448 EMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRT 507
Query: 674 RRTSK--QQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSS 731
RT K ++Y FLFND+L+I ++ + Y V D + R L VE +++
Sbjct: 508 LRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQ----------- 556
Query: 732 TMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTS- 790
+ +++F L +L N + + +L A +QSE RW+T+L + TS
Sbjct: 557 ------GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSR 610
Query: 791 ---LTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKE 847
QV+ V + A+QPDEL+L++AD++ I + DGW GERL D ERGWFP +E
Sbjct: 611 LLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEE 670
Query: 848 ITCQATIDKNVERMGRL 864
I +N++ R+
Sbjct: 671 ILNPKIRSQNLKECFRV 687
>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
Length = 1597
Score = 288 bits (736), Expect = 2e-77
Identities = 240/792 (30%), Positives = 372/792 (46%), Gaps = 100/792 (12%)
Query: 111 PKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPP---RTPNAPAPCTPEEDLTGLTA 167
PKS ++ GG S + A T PA V P RT PA E T +
Sbjct: 856 PKSRGRSRSTRGGHMNSGGH-AKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSR 914
Query: 168 SPVPSPTANGLAANN----------DSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPL 217
S S + G+A +N +P + G +KD E G+ P+ + E PL
Sbjct: 915 SK--SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKD-EAGVSEHPEAPARE---PL 968
Query: 218 QRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLK 277
+R Q+ + P VG+ + K S + + K+++ PH+R
Sbjct: 969 RRTTPQQG-----------ASGPGRSPVGQARQPEKP--SHLHLEKASSW---PHRR--- 1009
Query: 278 VRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKN 337
G G A SE N G R+GLR R +++ DS + +K+
Sbjct: 1010 --DSGRPPGDSSGQAVAPSEGANK--HKGWSRQGLR----RPSILPEGSSDSRGPAVEKH 1061
Query: 338 RMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKAL--DIDSDEE 395
P VV +K+ +G ++ K + + +LYQ Y + L +I S +
Sbjct: 1062 --PGPSDTVVFREKKPKEVMGGFSRRCSKLINS-----SQLLYQEYSDVVLNKEIQSQQR 1114
Query: 396 SE-------PKEQKSDEKIVIHHKPLR---------STWSQLSAVKRKGLSQTVSQEERK 439
E P + K ++ + S W ++ V+ + +++ E++K
Sbjct: 1115 LESLSETPGPSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQK 1174
Query: 440 RQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFI 499
QE FE+I SE SYL SL I + F+ S L T++ E LFS + DV + S F
Sbjct: 1175 LQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLS 1234
Query: 500 ELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSR 559
+LE +NNIF + D+V H Y+ Y TN+ YQ+RT Q L+ +N +F+EVL +
Sbjct: 1235 DLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEK 1294
Query: 560 IESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRL 619
+ES C+ L + SFLILP QR+TRL LL+ I ++T S + +A + +L+R
Sbjct: 1295 LESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRD 1354
Query: 620 CNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAY-VEDTVLFSRRTSK 678
CN + M RTE + ++ ++EF+ K FPL+S SRWLVK GELTA + R+ +
Sbjct: 1355 CNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNT 1414
Query: 679 QQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQ 738
+ V+ LFND L++++ + + V D++ + E C E P KN
Sbjct: 1415 RPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKC--EMKLHGPHKN--------- 1463
Query: 739 SSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSL------T 792
LF L + N + E L ETQSE+ RWI+AL P + L
Sbjct: 1464 -----LFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALA-----MPREELDLLECYNSP 1513
Query: 793 QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQA 852
QV+ +R++ ++ DEL+L+ ADVV++ Q+ SDGW EG RL DGERGWFP++ + I+
Sbjct: 1514 QVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
Query: 853 TIDKNVERMGRL 864
+N++ R+
Sbjct: 1574 VRAQNLKEAHRV 1585
>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
sapiens]
Length = 802
Score = 266 bits (681), Expect = 5e-71
Identities = 169/519 (32%), Positives = 271/519 (52%), Gaps = 49/519 (9%)
Query: 376 NAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKP---------------------- 413
N+VLYQ Y + A + + +E DE P
Sbjct: 291 NSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGS 350
Query: 414 LRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSD 473
S W + V+ G+ T+S + K QEA FE+I+SE SY+ SL + + F S ELS+
Sbjct: 351 TFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410
Query: 474 TMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYC 533
+ ++ LFS + +V S++F +LE R + ++ + D+V H + Y+ Y
Sbjct: 411 CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470
Query: 534 TNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTIC 593
TN+ YQ+RT Q+LL NP F +L+R+E C+ LP+ SFLILP QR+TRL +L++ I
Sbjct: 471 TNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENIL 530
Query: 594 QKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS 653
++T + S ++ +A + +LV+ CN + M+RTE + ++ ++ F+ K FPL+S +
Sbjct: 531 KRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA 590
Query: 654 RWLVKRGELT--AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQ 711
RWLV+ GEL A + + S + VY LFND L+++++K + V ++ +
Sbjct: 591 RWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAE 650
Query: 712 LLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERA 771
L V + +L PG H+F L +L + K + LL A T+SE+
Sbjct: 651 LQVRDL-SLKLQGIPG---------------HVFLLQLLHGQ-HMKHQFLLRARTESEKQ 693
Query: 772 RWITALGHSSGKPPADRTSLT------QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDG 825
RWI+AL SS P D+ ++ QV+ VR++ A PDEL+L+ D++ + SDG
Sbjct: 694 RWISALCPSS--PQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDG 751
Query: 826 WYEGERLRDGERGWFPMECAKEITCQATIDKNVERMGRL 864
W EG RL DGE+GW P +EI+ + +N+ R+
Sbjct: 752 WLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRV 790
>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
Length = 841
Score = 242 bits (618), Expect = 1e-63
Identities = 242/872 (27%), Positives = 375/872 (43%), Gaps = 94/872 (10%)
Query: 26 PHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVP-TASDSRTVHRSPLLL 84
P + R R ++ QSP P +G + P ++P ++D+ T +P+
Sbjct: 17 PRIIRPRPPSRSRAAQSPG-------PPHNGSS------PQELPRNSNDAPTPMCTPIFW 63
Query: 85 GAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVL 144
++ P AS L SP P + P SP S + + P P P +
Sbjct: 64 EPPAASLKPPALLPPSASRAS--LDSQTSPDSPSSTPTPSPVSRRSAS---PEPAPRSPV 118
Query: 145 RPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQSGRK--AKDPERGL 202
PP+ +P CTP + G+ A S +A G G GR A PE GL
Sbjct: 119 PPPKPSGSP--CTPLLPMAGVLAQN-GSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGL 175
Query: 203 FPGPQKSSSEQKLPLQRLPSQENELLEN--------PSVVLSTNSPAALK---VGKQQII 251
+ E++ PL SQEN + P V +T L+ VG + +
Sbjct: 176 -QARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEV 234
Query: 252 PK--SLASEIKISKSNNQNVE---PHKRLLKVRSMVEGLGGPLGHAGEESEVDNDVDSPG 306
P+ AS ++ S+S P L RS E PL + + V D G
Sbjct: 235 PRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFG 294
Query: 307 SLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLK 366
+ + +G DSP + + P V ++E ++LK
Sbjct: 295 DPPQPDLDLLSEDGIQTG---DSPDEAPQNT----PPATVEGREEEGL--------EVLK 339
Query: 367 GQGTFDGEENAVLYQNYKEKALD-----IDSDEESEPKEQKSDEKIVIHHKPLRSTWSQL 421
Q ++ LYQ Y+ L + D P P + W +L
Sbjct: 340 EQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQEL 399
Query: 422 SAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERH 481
AV+ GL T+S +ER+ QE++FEV++SE SYL SL +L F S+ L DT+T + H
Sbjct: 400 PAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHH 459
Query: 482 HLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQR 541
LFSN+ V S++F L +R +++ I D+ D+V H F YV Y N+ YQ+
Sbjct: 460 TLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEE 519
Query: 542 TLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSP 601
T +L+ TN F L R++S C LP+ SFL+LP QR+TRL +L+ I ++T + S
Sbjct: 520 TYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSS 579
Query: 602 KYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEF-KIKPFPLVSSSRWLVKRG 660
+ E ++AL VSK++ C+ +M++TE + + +L F K+K PLVS SR L +G
Sbjct: 580 RQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQG 639
Query: 661 ELT--AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCD 718
ELT VLF+ R + LF+D+L+IT+ KS + V DY+ R LV++
Sbjct: 640 ELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRS--LVQAQQ 697
Query: 719 NEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALG 778
+ + P F L++LSNH LL A + S+ RW+ A
Sbjct: 698 VPDPSGPP-----------------TFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFP 740
Query: 779 HSSGKPPADRT-----SLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLR 833
P + T +Q S + + SL+ + +GW +
Sbjct: 741 TPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLK----- 795
Query: 834 DGERGWFPMECAKEITCQATIDKNVERMGRLL 865
G G FP + E+T + +++ + RLL
Sbjct: 796 -GLPGAFPAQLVCEVTGEHERRRHLRQNQRLL 826
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 115 bits (288), Expect = 2e-25
Identities = 73/269 (27%), Positives = 140/269 (52%), Gaps = 7/269 (2%)
Query: 429 LSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNIT 488
L ++ ERKRQ I E+I +E +Y+ L+++ +F+ S+ +T+ E +F N
Sbjct: 1227 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWK 1286
Query: 489 DVCEASKKFFIELEARHQ---NNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQK 545
++ + K L R + + + I DI+ PY+++C+ ++ +Q+
Sbjct: 1287 ELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPH-MQPYIRFCSRQLNGAALIQQ 1345
Query: 546 LLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEV 605
P FKE + R+ C+ +P+ SF++ PMQRVTR PL++ I + TP++ P +
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 606 CKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAY 665
K AL++ +L NEG R+ E ++ + I + ++ + LV +S + +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS--VTNCLGPRKF 1463
Query: 666 VEDTVLFSRRTSKQQVYFFLFNDVLIITK 694
+ L+ +++K ++Y FLFND L++T+
Sbjct: 1464 LHSGKLYKAKSNK-ELYGFLFNDFLLLTQ 1491
Score = 43.1 bits (100), Expect = 0.001
Identities = 19/55 (34%), Positives = 33/55 (60%), Gaps = 3/55 (5%)
Query: 795 EIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGER---GWFPMECAK 846
+++ S+TA P++L+L ++LI ++ GW+EGE G++ GWFP K
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVK 1134
Score = 37.0 bits (84), Expect = 0.080
Identities = 36/171 (21%), Positives = 64/171 (37%), Gaps = 16/171 (9%)
Query: 689 VLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLT 748
++ + K+K E + RD+ +E E+ + P K R+ S
Sbjct: 639 IIELEKQKEEAQRRAQE---RDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
Query: 749 VLSNHANEKVEMLLGAETQSER----ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQ 804
A +K+ L + + A W TA + + + F ++
Sbjct: 696 KGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRS 755
Query: 805 PDELSLQVADVVLI-------YQRVSDGWYEGERLRDGERGWFPMECAKEI 848
DE+++Q D+V++ Q GW GE G+ GWFP A++I
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPANYAEKI 804
Score = 32.3 bits (72), Expect = 2.0
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 793 QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT 849
Q + + + AK+ + L+ DV+ + ++ D W+ GE G++GWFP K I+
Sbjct: 917 QAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEV--QGQKGWFPKSYVKLIS 970
Score = 30.0 bits (66), Expect = 9.7
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 790 SLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT 849
++ QV + +TA+ DEL+ ++ + + W++GE +G+ G FP K T
Sbjct: 1156 AVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGE--VNGQVGLFPSNYVKLTT 1213
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 112 bits (280), Expect = 1e-24
Identities = 75/272 (27%), Positives = 137/272 (50%), Gaps = 21/272 (7%)
Query: 432 TVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVC 491
T+ ERKRQ I E+I +E Y+ L++++ +F+ S +T+ E +F N ++
Sbjct: 1175 TMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELI 1234
Query: 492 EASKKFFIELEARHQNN---IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLA 548
++ K L R + + + I DI+ S Y+++C+ ++ LQ+
Sbjct: 1235 MSNTKLLKALRVRKKTGGEKMPVQMIGDILAAEL-SHMQAYIRFCSCQLNGAALLQQKTD 1293
Query: 549 TNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKR 608
+ FKE L ++ S C+ +P+ SFL+ PMQR+TR PLL+ +I + TP+ + K
Sbjct: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
Query: 609 ALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS-------RWLVKRGE 661
AL+ +L NEG R+ E ++ + I + ++ + L+ +S R L+ G+
Sbjct: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
Query: 662 LTAYVEDTVLFSRRTSKQQVYFFLFNDVLIIT 693
L + S ++++ FLFND L++T
Sbjct: 1414 L----------YKTKSNKELHGFLFNDFLLLT 1435
Score = 39.3 bits (90), Expect = 0.016
Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 780 SSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE---RLRDGE 836
S+ K A ++ ++ A ++LSL ++LI ++ + GW++GE R + +
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 837 RGWFPMECAK 846
+GWFP K
Sbjct: 1077 KGWFPASHVK 1086
Score = 32.7 bits (73), Expect = 1.5
Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 799 SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEI 848
S+TAK+ + L+ D++ + ++ + W+ GE G RGWFP K I
Sbjct: 881 SWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSYVKII 927
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 2/79 (2%)
Query: 771 ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE 830
A + LG SS + + QV + + A DELS ++ + + W++GE
Sbjct: 1082 ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1141
Query: 831 RLRDGERGWFPMECAKEIT 849
+G G FP K T
Sbjct: 1142 --INGVTGLFPSNYVKMTT 1158
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 112 bits (280), Expect = 1e-24
Identities = 75/272 (27%), Positives = 137/272 (50%), Gaps = 21/272 (7%)
Query: 432 TVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVC 491
T+ ERKRQ I E+I +E Y+ L++++ +F+ S +T+ E +F N ++
Sbjct: 1202 TMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELI 1261
Query: 492 EASKKFFIELEARHQNN---IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLA 548
++ K L R + + + I DI+ S Y+++C+ ++ LQ+
Sbjct: 1262 MSNTKLLKALRVRKKTGGEKMPVQMIGDILAAEL-SHMQAYIRFCSCQLNGAALLQQKTD 1320
Query: 549 TNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKR 608
+ FKE L ++ S C+ +P+ SFL+ PMQR+TR PLL+ +I + TP+ + K
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
Query: 609 ALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS-------RWLVKRGE 661
AL+ +L NEG R+ E ++ + I + ++ + L+ +S R L+ G+
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
Query: 662 LTAYVEDTVLFSRRTSKQQVYFFLFNDVLIIT 693
L + S ++++ FLFND L++T
Sbjct: 1441 L----------YKTKSNKELHGFLFNDFLLLT 1462
Score = 39.3 bits (90), Expect = 0.016
Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 780 SSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE---RLRDGE 836
S+ K A ++ ++ A ++LSL ++LI ++ + GW++GE R + +
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 837 RGWFPMECAK 846
+GWFP K
Sbjct: 1104 KGWFPASHVK 1113
Score = 32.7 bits (73), Expect = 1.5
Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 799 SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEI 848
S+TAK+ + L+ D++ + ++ + W+ GE G RGWFP K I
Sbjct: 908 SWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSYVKII 954
Score = 31.2 bits (69), Expect = 4.4
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 2/79 (2%)
Query: 771 ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE 830
A + LG SS + + QV + + A DELS ++ + + W++GE
Sbjct: 1109 ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1168
Query: 831 RLRDGERGWFPMECAKEIT 849
+G G FP K T
Sbjct: 1169 --INGVTGLFPSNYVKMTT 1185
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 99.0 bits (245), Expect = 2e-20
Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)
Query: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414
S+ GR KM + +G L + + D DS EE +++ D + L
Sbjct: 261 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 316
Query: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470
+W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E
Sbjct: 317 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 371
Query: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523
S + + E LFSNI ++ + ++ + LE + + D ++ K
Sbjct: 372 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 429
Query: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583
S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T
Sbjct: 430 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 489
Query: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631
+ PLL+ ++ +KT + K V +R + V+ +R E R +++ E
Sbjct: 490 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 549
Query: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680
++ + + +++ +K F P+ +S R L+ G L + + SK
Sbjct: 550 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 602
Query: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713
VY FLF D+L++TK KK+E + + L D+++
Sbjct: 603 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 637
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 99.0 bits (245), Expect = 2e-20
Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)
Query: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414
S+ GR KM + +G L + + D DS EE +++ D + L
Sbjct: 338 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 393
Query: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470
+W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E
Sbjct: 394 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 448
Query: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523
S + + E LFSNI ++ + ++ + LE + + D ++ K
Sbjct: 449 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 506
Query: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583
S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T
Sbjct: 507 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 566
Query: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631
+ PLL+ ++ +KT + K V +R + V+ +R E R +++ E
Sbjct: 567 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 626
Query: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680
++ + + +++ +K F P+ +S R L+ G L + + SK
Sbjct: 627 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 679
Query: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713
VY FLF D+L++TK KK+E + + L D+++
Sbjct: 680 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 714
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 99.0 bits (245), Expect = 2e-20
Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)
Query: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414
S+ GR KM + +G L + + D DS EE +++ D + L
Sbjct: 261 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 316
Query: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470
+W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E
Sbjct: 317 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 371
Query: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523
S + + E LFSNI ++ + ++ + LE + + D ++ K
Sbjct: 372 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 429
Query: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583
S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T
Sbjct: 430 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 489
Query: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631
+ PLL+ ++ +KT + K V +R + V+ +R E R +++ E
Sbjct: 490 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 549
Query: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680
++ + + +++ +K F P+ +S R L+ G L + + SK
Sbjct: 550 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 602
Query: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713
VY FLF D+L++TK KK+E + + L D+++
Sbjct: 603 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 637
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 99.0 bits (245), Expect = 2e-20
Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)
Query: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414
S+ GR KM + +G L + + D DS EE +++ D + L
Sbjct: 261 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 316
Query: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470
+W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E
Sbjct: 317 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 371
Query: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523
S + + E LFSNI ++ + ++ + LE + + D ++ K
Sbjct: 372 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 429
Query: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583
S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T
Sbjct: 430 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 489
Query: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631
+ PLL+ ++ +KT + K V +R + V+ +R E R +++ E
Sbjct: 490 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 549
Query: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680
++ + + +++ +K F P+ +S R L+ G L + + SK
Sbjct: 550 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 602
Query: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713
VY FLF D+L++TK KK+E + + L D+++
Sbjct: 603 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 637
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 99.0 bits (245), Expect = 2e-20
Identities = 97/395 (24%), Positives = 180/395 (45%), Gaps = 54/395 (13%)
Query: 355 SSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPL 414
S+ GR KM + +G L + + D DS EE +++ D + L
Sbjct: 317 SAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACL----RL 372
Query: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK----NSKE 470
+W +L K +++ + +QEA++E++ +E SY+ L ++I +F N +E
Sbjct: 373 EDSWRELIDGHEK-----LTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQE 427
Query: 471 LSDTMTKTERHHLFSNITDVCEASKKFFIE-----LEARHQNNIFIDDISDIVE--KHTA 523
S + + E LFSNI ++ + ++ + LE + + D ++ K
Sbjct: 428 -SGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP-GDFLKGFKMFG 485
Query: 524 STFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVT 583
S F PY++YC E ++ LL N F+ ++ E H C+ L + L P QR+T
Sbjct: 486 SLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLT 545
Query: 584 RLPLLMDTICQKTPKDSPKYEV------CKRALKEVSKLVRLCNEGAR------KMERTE 631
+ PLL+ ++ +KT + K V +R + V+ +R E R +++ E
Sbjct: 546 KYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYE 605
Query: 632 MMYTINSQLEFKIKPF-------PLVSSS----RWLVKRGELTAYVEDTVLFSRRTSKQQ 680
++ + + +++ +K F P+ +S R L+ G L + + SK
Sbjct: 606 VVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLR-------MKEGKDSKMD 658
Query: 681 VYFFLFNDVLIITK--KKSEESYNVNDYSLRDQLL 713
VY FLF D+L++TK KK+E + + L D+++
Sbjct: 659 VYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIV 693
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 87.4 bits (215), Expect = 5e-17
Identities = 72/261 (27%), Positives = 128/261 (49%), Gaps = 18/261 (6%)
Query: 437 ERKRQEAIFEVISSEHSYLLSLEILIRMF--KNSKELSDTMTKTER-HHLFSNITDVCEA 493
E+K + E++ +E +Y+ L++L ++F K +E + E + +FSNI+ +
Sbjct: 204 EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAF 263
Query: 494 SKKFFI-ELEARHQNNIFIDDISDIVEKHTA--STFDPYVKYCTNEVYQQRTLQKLLATN 550
KF + ELE R Q I DI++K + YVK N + + + + +
Sbjct: 264 HSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERI--- 320
Query: 551 PSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRAL 610
P FK V+ I+ + C +L + ++ P+QR+ R +L+ +K P DS + K++L
Sbjct: 321 PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSL 380
Query: 611 KEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTV 670
+ +S N RKME + + I L + +V+ S L+K G++
Sbjct: 381 EIISTAASHSNSAIRKMENLKKLLEIYEMLG---EEEDIVNPSNELIKEGQILK------ 431
Query: 671 LFSRRTSKQQVYFFLFNDVLI 691
L +R TS Q+ Y FLFN++L+
Sbjct: 432 LAARNTSAQERYLFLFNNMLL 452
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 86.3 bits (212), Expect = 1e-16
Identities = 76/315 (24%), Positives = 148/315 (46%), Gaps = 35/315 (11%)
Query: 394 EESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTV----SQEERKRQEAIFEVIS 449
E++ E E + + L S ++LS+ + Q V S + ++ + E++
Sbjct: 53 EKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLE 112
Query: 450 SEHSYLLSLEILIRMF--------KNSKELSDTMTKTERHHLFSNITDVCEASKKFFI-E 500
+E +Y+ L +L ++F ++SK + + + +FSNI+ + + +FF+ E
Sbjct: 113 TEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRV----IFSNISSIYQFHSQFFLPE 168
Query: 501 LEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLAT----NPSFKEV 556
L+ R + I D+++K P++K + V +LLAT +P F+EV
Sbjct: 169 LQRRLDDWTANPRIGDVIQK-----LAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEV 223
Query: 557 LSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKL 616
L+RI+S E +L + ++ P+QR+ R LL+ QK P +P ++AL +
Sbjct: 224 LTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSA 283
Query: 617 VRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRT 676
+ N +MER + ++ + +L + +V S L++ G + + RR
Sbjct: 284 AQHSNAAITEMERLQDLWEVYQRLGLE---DDIVDPSNTLLREGPVLK------ISFRRN 334
Query: 677 SKQQVYFFLFNDVLI 691
+ Y FLFN++L+
Sbjct: 335 DPMERYLFLFNNMLL 349
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 83.6 bits (205), Expect = 7e-16
Identities = 77/353 (21%), Positives = 157/353 (44%), Gaps = 30/353 (8%)
Query: 437 ERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKK 496
E KRQE I E+ +E +++ +L++L ++F ++ +E +FSN+ D+ +
Sbjct: 785 EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844
Query: 497 FFIELEARHQNN--IFIDDISDIVE-----------KHTASTFDPYVKYCTNEVYQQRTL 543
+++A + N ID I + + KH A+TF C+N+ + +
Sbjct: 845 LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATF------CSNQPFALEMI 898
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
+ + F+ + ES+ CR L + + MQR+T+ PLL+D I + T + +
Sbjct: 899 KSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTERE 958
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLE---FKIKPFPLVSSSRWLVKRG 660
+V K+A +++ N+ ++ E + + +L+ K+ +P V R L
Sbjct: 959 KV-KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTK 1017
Query: 661 ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE 720
+ V R +Y L D+L++ +K+ + ++L + D++
Sbjct: 1018 RKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLV----LRCHSKILASTADSK 1073
Query: 721 ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARW 773
S K S+ ++ + LF +++ N A + E++ A+T SE+ W
Sbjct: 1074 HTFSPVIKLSTVLVRQVATDNKALFVISMSDNGA-QIYELV--AQTVSEKTVW 1123
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 82.4 bits (202), Expect = 2e-15
Identities = 98/454 (21%), Positives = 190/454 (41%), Gaps = 39/454 (8%)
Query: 271 PHKRLLKVRSM-VEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDS 329
P +R + + EG GP +++D SLRRG T + G ++D
Sbjct: 13 PRRRSRRASGLSTEGATGPSADTS-----GSELDGRCSLRRGSSFTF----LTPGPNWDF 63
Query: 330 PTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEEN-AVLYQNYKEKAL 388
K++ + V ++ KE + R ++ N AV ++
Sbjct: 64 TLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSF 123
Query: 389 DIDSDEESEPKEQKSDEKIVIHHKPLRST---WSQLSAVKRKGLSQTVSQEERKRQEAIF 445
+ D S QK + + R + WS++ + K ++++ E +RQEAI+
Sbjct: 124 TLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMK---ESLTTREIRRQEAIY 180
Query: 446 EVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARH 505
E+ E + L++ + + + M++ E H+F ++ + +
Sbjct: 181 EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT 240
Query: 506 QNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHED 565
+ + ++ I I+ + Y YC+N++ + L + +P ++ L R
Sbjct: 241 KPDGTVEQIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLESPF 298
Query: 566 CRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGAR 625
R L + SFL +P R+ + PLL+ I + TPK+ P ++ + A+ + ++ N
Sbjct: 299 SRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN---L 355
Query: 626 KMERTEMMYTINSQLEF--KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYF 683
K +E Y I+ +LE+ + + P + +S+ L+ GEL R S ++Y
Sbjct: 356 KKGESECQYYID-KLEYLDEKQRDPRIEASKVLLCHGEL-----------RSKSGHKLYI 403
Query: 684 FLFNDVLIITK---KKSEESYNVNDYSLRDQLLV 714
FLF D+L++T+ + SY V + Q LV
Sbjct: 404 FLFQDILVLTRPVTRNERHSYQVYRQPIPVQELV 437
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 80.5 bits (197), Expect = 6e-15
Identities = 75/337 (22%), Positives = 150/337 (44%), Gaps = 28/337 (8%)
Query: 386 KALDIDSDEESEPKEQKSDEKIVIHHKPLRST---WSQLSAVKRKGLSQTVSQEERKRQE 442
++ + D S QK + + R + WS++ + K ++++ E +RQE
Sbjct: 67 QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMK---ESLTTREIRRQE 123
Query: 443 AIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELE 502
AI+E+ E + L++ + + + M++ E H+F ++ + +
Sbjct: 124 AIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIG 183
Query: 503 ARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIES 562
+ + ++ I I+ + Y YC+N++ + L + +P ++ L R
Sbjct: 184 EATKPDGTVEQIGHILVSWLPR-LNAYRGYCSNQLAAKALLDQK-KQDPRVQDFLQRCLE 241
Query: 563 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNE 622
R L + SFL +P R+ + PLL+ I + TPK+ P ++ + A+ + ++ N
Sbjct: 242 SPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN- 300
Query: 623 GARKMERTEMMYTINSQLEF--KIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQ 680
K +E Y I+ +LE+ + + P + +S+ L+ GEL R S +
Sbjct: 301 --LKKGESECQYYID-KLEYLDEKQRDPRIEASKVLLCHGEL-----------RSKSGHK 346
Query: 681 VYFFLFNDVLIITK---KKSEESYNVNDYSLRDQLLV 714
+Y FLF D+L++T+ + SY V + Q LV
Sbjct: 347 LYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELV 383
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 79.0 bits (193), Expect = 2e-14
Identities = 74/364 (20%), Positives = 157/364 (43%), Gaps = 36/364 (9%)
Query: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCE 492
++Q E RQE I E+ +E S+L +L +L +F + + M + E LF N+ ++ E
Sbjct: 768 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 827
Query: 493 ASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVK---------YCTNEVYQQRTL 543
+ ++ + I +ISD++ + FD + +C+ + +
Sbjct: 828 IHNSWCEAMKKLREEGPIIKEISDLM----LARFDGPAREELQQVAAQFCSYQSIALELI 883
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
+ F+ + ESH CR L + +I MQR+T+ PLL+++I + T + ++
Sbjct: 884 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 943
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLE---FKIKPFPLVS-------SS 653
E RA + ++++ NE ++ E + +L+ + PL + ++
Sbjct: 944 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 1003
Query: 654 RWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLL 713
R ++ G LT + + ++ L D+L++ +K+ E+ +
Sbjct: 1004 RKMIHEGPLTWRIS-------KDKTLDLHVLLLEDLLVLLQKQDEKLL----LKCHSKTA 1052
Query: 714 VESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARW 773
V S D+++ S K ++ ++ S + F + + E++ A T S++ W
Sbjct: 1053 VGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELV--ALTSSDKNTW 1110
Query: 774 ITAL 777
+ L
Sbjct: 1111 MELL 1114
Score = 33.9 bits (76), Expect = 0.67
Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 4/40 (10%)
Query: 121 PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEE 160
P G+P+ + +P+PPPPP L PP+ P P E
Sbjct: 138 PAGAPRITS----VIPSPPPPPPLPPPQRITGPKPLQDPE 173
Score = 30.8 bits (68), Expect = 5.7
Identities = 26/97 (26%), Positives = 38/97 (39%), Gaps = 11/97 (11%)
Query: 131 GAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQ 190
GA +P PPPP R P P P E D S +G + PG G+
Sbjct: 1126 GAAPMPVHPPPPGPREP-AQQGPTPSRVELD---------DSDVFHGEPEPEELPG-GTG 1174
Query: 191 SGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENEL 227
S ++ + + L P++ S ++ L LP L
Sbjct: 1175 SQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSL 1211
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 79.0 bits (193), Expect = 2e-14
Identities = 74/364 (20%), Positives = 157/364 (43%), Gaps = 36/364 (9%)
Query: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCE 492
++Q E RQE I E+ +E S+L +L +L +F + + M + E LF N+ ++ E
Sbjct: 728 LTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIE 787
Query: 493 ASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVK---------YCTNEVYQQRTL 543
+ ++ + I +ISD++ + FD + +C+ + +
Sbjct: 788 IHNSWCEAMKKLREEGPIIKEISDLM----LARFDGPAREELQQVAAQFCSYQSIALELI 843
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
+ F+ + ESH CR L + +I MQR+T+ PLL+++I + T + ++
Sbjct: 844 KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 903
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLE---FKIKPFPLVS-------SS 653
E RA + ++++ NE ++ E + +L+ + PL + ++
Sbjct: 904 EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTT 963
Query: 654 RWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLL 713
R ++ G LT + + ++ L D+L++ +K+ E+ +
Sbjct: 964 RKMIHEGPLTWRIS-------KDKTLDLHVLLLEDLLVLLQKQDEKLL----LKCHSKTA 1012
Query: 714 VESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARW 773
V S D+++ S K ++ ++ S + F + + E++ A T S++ W
Sbjct: 1013 VGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELV--ALTSSDKNTW 1070
Query: 774 ITAL 777
+ L
Sbjct: 1071 MELL 1074
Score = 33.9 bits (76), Expect = 0.67
Identities = 15/40 (37%), Positives = 21/40 (52%), Gaps = 4/40 (10%)
Query: 121 PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEE 160
P G+P+ + +P+PPPPP L PP+ P P E
Sbjct: 138 PAGAPRITS----VIPSPPPPPPLPPPQRITGPKPLQDPE 173
Score = 30.8 bits (68), Expect = 5.7
Identities = 26/97 (26%), Positives = 38/97 (39%), Gaps = 11/97 (11%)
Query: 131 GAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQ 190
GA +P PPPP R P P P E D S +G + PG G+
Sbjct: 1086 GAAPMPVHPPPPGPREP-AQQGPTPSRVELD---------DSDVFHGEPEPEELPG-GTG 1134
Query: 191 SGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENEL 227
S ++ + + L P++ S ++ L LP L
Sbjct: 1135 SQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSL 1171
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 78.6 bits (192), Expect = 2e-14
Identities = 77/309 (24%), Positives = 138/309 (44%), Gaps = 28/309 (9%)
Query: 389 DIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVI 448
++DSD E E E++ +EK PL +++ + TV Q K E++
Sbjct: 334 EVDSDLEEEDDEEEEEEKDREIPVPLME--------RQESVELTVQQ---KVFHIANELL 382
Query: 449 SSEHSYLLSLEILIRMFKNSKELSDTMTKTER-----HHLFSNITDVCEASKKFFI-ELE 502
+E +Y+ L +L ++F ++ L + ++ H +FSNI + ++F + ELE
Sbjct: 383 QTEKAYVSRLHLLDQVFC-ARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELE 441
Query: 503 ARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIES 562
R + I DI++K A Y +Y N + + FK ++ ++
Sbjct: 442 KRMEEWDRYPRIGDILQK-LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQK 500
Query: 563 HEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNE 622
E C NL + ++ P+QR+ R LL+ K P SP + +++L+ ++ N
Sbjct: 501 EEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNA 560
Query: 623 GARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVY 682
RKMER M+ + E +VS ++ L+K G + L ++ + Q Y
Sbjct: 561 AIRKMER---MHKLLKVYELLGGEEDIVSPTKELIKEGHILK------LSAKNGTTQDRY 611
Query: 683 FFLFNDVLI 691
LFND L+
Sbjct: 612 LILFNDRLL 620
Score = 36.6 bits (83), Expect = 0.10
Identities = 47/190 (24%), Positives = 63/190 (33%), Gaps = 40/190 (21%)
Query: 35 PRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANG 94
P+PQ P+ L + P L P P +D R + +A
Sbjct: 157 PKPQVPPKPSYLQMPRMPPP----LEPIPPPPSRPLPADPRVA-----------KGLAPR 201
Query: 95 GTASPEYRAASPRL----RRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTP 150
ASP A S + R P + VPG SP PP PV+ P T
Sbjct: 202 AEASPSSAAVSSLIEKFEREPVIVASDRPVPGPSPG------------PPEPVMLPQPTS 249
Query: 151 NAPAPCTPEEDLTGLTASPVPSPTANGLAANND-------SPGSGSQSGRKAKD--PERG 201
P P PE + + P P N D SP + ++ + D P
Sbjct: 250 QPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHS 309
Query: 202 LFPGPQKSSS 211
L PGP +S
Sbjct: 310 LCPGPPALAS 319
Score = 30.8 bits (68), Expect = 5.7
Identities = 49/212 (23%), Positives = 71/212 (33%), Gaps = 56/212 (26%)
Query: 24 PQPHQVLG------RSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTV 77
PQ H+ L S+PRP +Q N +L+ ++ G +L
Sbjct: 83 PQHHRALRFSYHLEGSQPRPGLHQG-NRILVKSLSLDPGQSL------------------ 123
Query: 78 HRSPLLLGAQR-RAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLP 136
P G QR R+ T +P R P K PG P+ P +
Sbjct: 124 --EPHPEGPQRLRSDPGPPTETPSQR-----------PSPLKRAPGPKPQVPPKPSYLQM 170
Query: 137 APPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA------------NNDS 184
PPP+ P P+ P P P GL SP++ +++ +D
Sbjct: 171 PRMPPPLEPIPPPPSRPLPADPRV-AKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDR 229
Query: 185 PGSGSQSGRKAKDPERGLFPGPQKSSSEQKLP 216
P G G PE + P P +LP
Sbjct: 230 PVPGPSPG----PPEPVMLPQPTSQPPVPQLP 257
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 76.6 bits (187), Expect = 9e-14
Identities = 87/384 (22%), Positives = 163/384 (42%), Gaps = 32/384 (8%)
Query: 428 GLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMF-KNSKELSDTMTKTERHHLFSN 486
G ++ S +++ R I E++S+E Y+ L + + + ++ +D ++ + +F N
Sbjct: 273 GGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGN 332
Query: 487 ITDVCEASKKFFIELEAR-HQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQK 545
I D+ K F LE R ++ + ++ +H A F Y +YC N L +
Sbjct: 333 IEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQAD-FQIYSEYCNNHPNACVELSR 391
Query: 546 L--LATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
L L+ F E ++ D + + FL+ P+Q++ + PL + + + T +
Sbjct: 392 LTKLSKYVYFFEACRLLQKMID---ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDF 448
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELT 663
+ + AL + + +L NE R++E + + S +E LV SS L+ GELT
Sbjct: 449 KDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSE-LIYSGELT 507
Query: 664 AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKK---KSEESYNVNDYSLRDQLLVESCDNE 720
+ + QQ FFLF+ LI KK + + Y + +V+ D +
Sbjct: 508 RVTQP------QAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGLEVVDLEDGK 561
Query: 721 ELNSSPGKNSSTMLYSRQSSASHLFTLTV-------LSNHANEKVEMLLGAET------- 766
+ + ++ L+ + SHL L A E+ ++ L ET
Sbjct: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQETGFSITEL 621
Query: 767 QSERARWITALGHSSGKPPADRTS 790
Q ++A + +GKP RT+
Sbjct: 622 QRKQAMLNASKQQVTGKPKGRRTA 645
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 75.1 bits (183), Expect = 3e-13
Identities = 65/280 (23%), Positives = 122/280 (43%), Gaps = 12/280 (4%)
Query: 422 SAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFK-----NSKELSDTMT 476
S K S V ++ R + E+ +E +Y+ L +I++F+ + +
Sbjct: 404 SCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILA 463
Query: 477 KTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNE 536
E +F +I D+ + K +LE N I DI K++ Y +
Sbjct: 464 PEEIKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFF 523
Query: 537 VYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKT 596
+ T+ K P F L ++ +C ++ LI P+QR+ + LL++ + + T
Sbjct: 524 EMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHT 583
Query: 597 PKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWL 656
++P ++A+ + +++ NE RK E + ++ + +++ P L+SS R L
Sbjct: 584 ADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDG--CPANLLSSHRSL 641
Query: 657 VKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKK 696
V+R E + E +QV FLFND L I +K+
Sbjct: 642 VQRVETISLGEHPC-----DRGEQVTLFLFNDCLEIARKR 676
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 75.1 bits (183), Expect = 3e-13
Identities = 67/272 (24%), Positives = 123/272 (45%), Gaps = 15/272 (5%)
Query: 428 GLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMF-KNSKELSDTMTKTERHHLFSN 486
G ++ S +++ R I E++S+E Y+ L + + + ++ +D ++ + +F N
Sbjct: 273 GGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGN 332
Query: 487 ITDVCEASKKFFIELEAR-HQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQK 545
I D+ K F LE R ++ + ++ +H A F Y +YC N L +
Sbjct: 333 IEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQAD-FQIYSEYCNNHPNACVELSR 391
Query: 546 L--LATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
L L+ F E ++ D + + FL+ P+Q++ + PL + + + T +
Sbjct: 392 LTKLSKYVYFFEACRLLQKMID---ISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDF 448
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELT 663
+ + AL + + +L NE R++E + + S +E LV SS L+ GELT
Sbjct: 449 KDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSE-LIYSGELT 507
Query: 664 AYVEDTVLFSRRTSKQQVYFFLFNDVLIITKK 695
+ + QQ FFLF+ LI KK
Sbjct: 508 RVTQP------QAKSQQRMFFLFDHQLIYCKK 533
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 74.7 bits (182), Expect = 3e-13
Identities = 87/365 (23%), Positives = 164/365 (44%), Gaps = 50/365 (13%)
Query: 438 RKRQEAIFEVISSEHSYLLSLEILIRMFKNS--KELSDTMTK--TERHH--LFSNITDVC 491
R R + E++ +E Y+ +L L F + + ++D++ K TE + LFSNI D+
Sbjct: 48 RLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDIL 107
Query: 492 EASKKFFIELE-ARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATN 550
E K F LE H ++ ++ K F Y +YC+N ++ L+ L+ N
Sbjct: 108 EVHKDFLAALEYCLHPEPQSQHELGNVFLKFK-DKFCVYEEYCSNH---EKALRLLVELN 163
Query: 551 --PSFKEVL--SRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVC 606
P+ + L + ++P+ +L+ P+QR+ + PLL+ + ++TP P +
Sbjct: 164 KIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAV 223
Query: 607 KRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYV 666
+ AL+ + + NE R+ME+ E + + S +E + L L+ +G
Sbjct: 224 QSALQAMKTVCSNINETKRQMEKLEALEQLQSHIE-GWEGSNLTDICTQLLLQG------ 276
Query: 667 EDTVLFSRRTSKQQVYFFLFNDVLIITKKKSE-----------ESYNVNDYSLRDQLLVE 715
T+L + Q+ FFLF+++L+ K+KS +S N + Y R ++ E
Sbjct: 277 --TLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTE 334
Query: 716 SCDNEELNSSPGKNSSTMLYSRQSSASHLFTLT---VLSNHANEKVEMLLGAETQSERAR 772
+ E + S+ +T+T + N A K + + A+T E+ +
Sbjct: 335 VMEVENVEDGTA-----------DYHSNGYTVTNGWKIHNTAKNKWFVCM-AKTAEEKQK 382
Query: 773 WITAL 777
W+ A+
Sbjct: 383 WLDAI 387
>gi|222080070 pleckstrin homology domain-containing family G member
6 isoform b [Homo sapiens]
Length = 758
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 27/288 (9%)
Query: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKN---SKELSDTMTKTERHHLFSNITD 489
+SQE +QEA++E++++E Y+ L+I+ + + + + + LF N+
Sbjct: 123 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 182
Query: 490 VCEASKKFFIE-----LEARHQNNIFIDDISDIVEKHT-ASTFDPYVKYCTNEVYQQRTL 543
+ + F+ E LE + +D I T F PYV+YC
Sbjct: 183 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA 242
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
++ TNP F + E H+ + LI P QR+T+ PLL+ + +++P ++
Sbjct: 243 REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQ 301
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMM---------YTI----NSQLEFKIKPF--- 647
E ++ V +R N R+ E E + Y + + ++E ++PF
Sbjct: 302 EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTL 361
Query: 648 PLVSSSRWLVKRGELTAYVEDTVLFSR-RTSKQQVYFFLFNDVLIITK 694
L S + +E V R K VY FLF+DVL++TK
Sbjct: 362 DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 409
>gi|222080068 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 27/288 (9%)
Query: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKN---SKELSDTMTKTERHHLFSNITD 489
+SQE +QEA++E++++E Y+ L+I+ + + + + + LF N+
Sbjct: 155 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 214
Query: 490 VCEASKKFFIE-----LEARHQNNIFIDDISDIVEKHT-ASTFDPYVKYCTNEVYQQRTL 543
+ + F+ E LE + +D I T F PYV+YC
Sbjct: 215 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA 274
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
++ TNP F + E H+ + LI P QR+T+ PLL+ + +++P ++
Sbjct: 275 REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQ 333
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMM---------YTI----NSQLEFKIKPF--- 647
E ++ V +R N R+ E E + Y + + ++E ++PF
Sbjct: 334 EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTL 393
Query: 648 PLVSSSRWLVKRGELTAYVEDTVLFSR-RTSKQQVYFFLFNDVLIITK 694
L S + +E V R K VY FLF+DVL++TK
Sbjct: 394 DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
>gi|222080066 pleckstrin homology domain-containing family G member
6 isoform a [Homo sapiens]
Length = 790
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/288 (24%), Positives = 123/288 (42%), Gaps = 27/288 (9%)
Query: 433 VSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKN---SKELSDTMTKTERHHLFSNITD 489
+SQE +QEA++E++++E Y+ L+I+ + + + + + LF N+
Sbjct: 155 MSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPS 214
Query: 490 VCEASKKFFIE-----LEARHQNNIFIDDISDIVEKHT-ASTFDPYVKYCTNEVYQQRTL 543
+ + F+ E LE + +D I T F PYV+YC
Sbjct: 215 LIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYA 274
Query: 544 QKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKY 603
++ TNP F + E H+ + LI P QR+T+ PLL+ + +++P ++
Sbjct: 275 REQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSP-EARAQ 333
Query: 604 EVCKRALKEVSKLVRLCNEGARKMERTEMM---------YTI----NSQLEFKIKPF--- 647
E ++ V +R N R+ E E + Y + + ++E ++PF
Sbjct: 334 EALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTL 393
Query: 648 PLVSSSRWLVKRGELTAYVEDTVLFSR-RTSKQQVYFFLFNDVLIITK 694
L S + +E V R K VY FLF+DVL++TK
Sbjct: 394 DLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTK 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,702,400
Number of Sequences: 37866
Number of extensions: 1962812
Number of successful extensions: 20448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 417
Number of HSP's successfully gapped in prelim test: 1295
Number of HSP's that attempted gapping in prelim test: 11038
Number of HSP's gapped (non-prelim): 6197
length of query: 871
length of database: 18,247,518
effective HSP length: 111
effective length of query: 760
effective length of database: 14,044,392
effective search space: 10673737920
effective search space used: 10673737920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.