Search of human proteins with 194248068

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
         (1343 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi...  2716   0.0  
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho...  1073   0.0  
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho...  1019   0.0  
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]   1016   0.0  
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]      967   0.0  
gi|130502162 RAS protein activator like 3 [Homo sapiens]              409   e-114
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]       150   1e-35
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]      150   1e-35
gi|38201692 RAS p21 protein activator 3 [Homo sapiens]                125   2e-28
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...   115   2e-25
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...   115   2e-25
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...   115   2e-25
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...   115   2e-25
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]     115   4e-25
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]     115   4e-25
gi|12545408 RAS p21 protein activator 2 [Homo sapiens]                112   2e-24
gi|4759026 RAS protein activator like 1 [Homo sapiens]                108   3e-23
gi|4557793 neurofibromin isoform 2 [Homo sapiens]                      95   4e-19
gi|109826564 neurofibromin isoform 1 [Homo sapiens]                    91   6e-18
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap...    62   5e-09
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...    62   5e-09
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]            61   8e-09
gi|4507955 YY1 transcription factor [Homo sapiens]                     61   8e-09
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ...    58   5e-08
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ...    58   5e-08
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ...    58   5e-08
gi|55750053 atrophin-1 [Homo sapiens]                                  58   7e-08
gi|55750041 atrophin-1 [Homo sapiens]                                  58   7e-08
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma...    56   2e-07
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s...    55   3e-07

>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
          Length = 1343

 Score = 2716 bits (7040), Expect = 0.0
 Identities = 1343/1343 (100%), Positives = 1343/1343 (100%)

Query: 1    MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLD 60
            MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLD
Sbjct: 1    MSRSRASIHRGSIPAMSYAPFRDVRGPSMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLD 60

Query: 61   EDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEG 120
            EDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEG
Sbjct: 61   EDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEG 120

Query: 121  APAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKES 180
            APAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKES
Sbjct: 121  APAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKES 180

Query: 181  HSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERD 240
            HSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERD
Sbjct: 181  HSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERD 240

Query: 241  KWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRS 300
            KWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRS
Sbjct: 241  KWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRS 300

Query: 301  ASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTE 360
            ASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTE
Sbjct: 301  ASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTE 360

Query: 361  QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEF 420
            QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEF
Sbjct: 361  QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEF 420

Query: 421  AEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMERE 480
            AEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMERE
Sbjct: 421  AEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMERE 480

Query: 481  HLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQ 540
            HLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQ
Sbjct: 481  HLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQ 540

Query: 541  ANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCP 600
            ANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCP
Sbjct: 541  ANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCP 600

Query: 601  AIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSM 660
            AIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSM
Sbjct: 601  AIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSM 660

Query: 661  QQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLND 720
            QQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLND
Sbjct: 661  QQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLND 720

Query: 721  ISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSS 780
            ISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSS
Sbjct: 721  ISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSS 780

Query: 781  MDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKS 840
            MDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKS
Sbjct: 781  MDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKS 840

Query: 841  VSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSIT 900
            VSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSIT
Sbjct: 841  VSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSIT 900

Query: 901  AAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHH 960
            AAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHH
Sbjct: 901  AAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHH 960

Query: 961  HHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRR 1020
            HHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRR
Sbjct: 961  HHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRR 1020

Query: 1021 QLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSA 1080
            QLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSA
Sbjct: 1021 QLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSA 1080

Query: 1081 AQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQT 1140
            AQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQT
Sbjct: 1081 AQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQT 1140

Query: 1141 PSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEE 1200
            PSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEE
Sbjct: 1141 PSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEE 1200

Query: 1201 EIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIK 1260
            EIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIK
Sbjct: 1201 EIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIK 1260

Query: 1261 SIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP 1320
            SIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP
Sbjct: 1261 SIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAP 1320

Query: 1321 PAPPPPPRLQITENGEFRNTADH 1343
            PAPPPPPRLQITENGEFRNTADH
Sbjct: 1321 PAPPPPPRLQITENGEFRNTADH 1343


>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
            sapiens]
          Length = 1132

 Score = 1073 bits (2774), Expect = 0.0
 Identities = 610/1222 (49%), Positives = 791/1222 (64%), Gaps = 137/1222 (11%)

Query: 107  RKSVPGG---KQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRF 163
            R+S+PG    K  SME + A PFR + GFLSRRLK SIKRTKSQPKLDR  SFR ILP F
Sbjct: 23   RRSLPGSLSEKSPSMEPSAATPFRVT-GFLSRRLKGSIKRTKSQPKLDRNHSFRHILPGF 81

Query: 164  RSA-----DHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEF 218
            RSA     D++R+ LM   KES SHESLLSPSSA EAL+L+++E+ +IKPVHSSILGQ++
Sbjct: 82   RSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDY 141

Query: 219  CFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKK 278
            CFEVTTSSG+KCF+CRSAAERDKW+ENL+RAV PNKDNSRRV+++LKLW+IEA++LP KK
Sbjct: 142  CFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKK 201

Query: 279  RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKD 338
            +Y CELCLDD+LYARTT K ++   D VFWGEHFEF+NLP +R + +HLYR++DKK+KK+
Sbjct: 202  KYLCELCLDDVLYARTTGKLKT---DNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKE 258

Query: 339  KAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCP 398
            +  Y+GLV++P A++AGR F E+WYPV  P   GG                    KG  P
Sbjct: 259  RNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGG--------------------KGPGP 298

Query: 399  AVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQST 458
             +R+KARYQT++ILPME+YKEFAE++TNHY  LCA LEP L+ K KEE+ASALVHILQST
Sbjct: 299  MIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQST 358

Query: 459  GKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALY 518
            GK KDFL+D+ MSEVDR  + EHLIFRENTLATKAIEEY++L+GQKYL+DA+GEFI+ALY
Sbjct: 359  GKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALY 418

Query: 519  ESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAE 578
            ES+ENCEVDP KC+A+ L EHQ NL+MCCELA CK++NS+CVFPRELKEVFASWR  C+ 
Sbjct: 419  ESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSS 478

Query: 579  RGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSK 638
            RGR DI++RLISASLFLRFLCPAIMSPSLF L+QEYPD++T+RTLTLIAKV QNLANF+K
Sbjct: 479  RGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK 538

Query: 639  FTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWE 698
            F SKE+++ FMN+FLE EW +MQ+FL EISN +TL+N++ FEGYIDLGRELS+LH+LLWE
Sbjct: 539  FGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWE 598

Query: 699  VLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGY 758
             + QL +  + KLGPLPR+L D+ TAL  P   + P        P      G S+   G 
Sbjct: 599  AVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPG----SGSSSISAGL 654

Query: 759  MMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSP 818
                       +  +   L+  +D  RLPSPT E          KDLF+V+R    + SP
Sbjct: 655  Q----------KMVIENDLSGLIDFTRLPSPTPE---------NKDLFFVTRSSGVQPSP 695

Query: 819  AYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLT 878
            A  +S S+  EP+ +M +  KS+SM+DLQ      R       + A    L    QA+  
Sbjct: 696  ARSSSYSEANEPDLQMANGGKSLSMVDLQ----DARTLDGEAGSPAGPDVLPTDGQAAAA 751

Query: 879  AALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQ-QLRIPLSFQNPLFHMAAD 937
              +   PA A  ++    +++  AG   +  G T++G P + QL  PLSFQNP++ MAA 
Sbjct: 752  QLVAGWPARATPVNLAGLATVRRAGQTPTTPG-TSEGAPGRPQLLAPLSFQNPVYQMAAG 810

Query: 938  GPGPPGGHGGGG--GHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKP 995
             P  P G G  G  GH   SSH                         S SE+L++     
Sbjct: 811  LPLSPRGLGDSGSEGHSSLSSH-------------------------SNSEELAA----- 840

Query: 996  PAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQR----PAPSGPGG 1051
             AA +    + ++E      +  RRQ+SL +       P Q + GPQR    P P  P  
Sbjct: 841  -AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPP-- 897

Query: 1052 GSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPA-RPRQQSLS 1110
                         PPP  RG++    +S  Q PRPSSG L  +     GP+ R RQQS S
Sbjct: 898  ------------PPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSS 945

Query: 1111 KEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIES 1170
             +G               LKP     H Q PS ++P   A +RT AW+  M     + E 
Sbjct: 946  SKGD-----------SPELKPRAV--HKQGPSPVSPN--ALDRTAAWLLTMNAQLLEDEG 990

Query: 1171 AHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQT 1230
               +      ++  +S DE     + + E+++  L+++L +S +KLEEYE     QEE T
Sbjct: 991  LGPDPPH---RDRLRSKDE-----LSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETT 1042

Query: 1231 SKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKR 1290
             K++++YQARLE+ E+RLR+QQ +KD Q+K II RLM VEEEL++DH  M +   + K++
Sbjct: 1043 QKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEM-QAAVDSKQK 1101

Query: 1291 LLDAQERQLPPLGPTNPRVTLA 1312
            ++DAQE+++  L   N R+  A
Sbjct: 1102 IIDAQEKRIASLDAANARLMSA 1123


>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
            sapiens]
          Length = 1065

 Score = 1019 bits (2635), Expect = 0.0
 Identities = 579/1187 (48%), Positives = 759/1187 (63%), Gaps = 141/1187 (11%)

Query: 174  MQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFAC 233
            M   KES SHESLLSPSSA EAL+L+++E+ +IKPVHSSILGQ++CFEVTTSSG+KCF+C
Sbjct: 1    MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60

Query: 234  RSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYAR 293
            RSAAERDKW+ENL+RAV PNKDNSRRV+++LKLW+IEA++LP KK+Y CELCLDD+LYAR
Sbjct: 61   RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120

Query: 294  TTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATL 353
            TT K ++   D VFWGEHFEF+NLP +R + +HLYR++DKK+KK++  Y+GLV++P A++
Sbjct: 121  TTGKLKT---DNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASV 177

Query: 354  AGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILP 413
            AGR F E+WYPV  P   GG                    KG  P +R+KARYQT++ILP
Sbjct: 178  AGRQFVEKWYPVVTPNPKGG--------------------KGPGPMIRIKARYQTITILP 217

Query: 414  MELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEV 473
            ME+YKEFAE++TNHY  LCA LEP L+ K KEE+ASALVHILQSTGK KDFL+D+ MSEV
Sbjct: 218  MEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 277

Query: 474  DRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTA 533
            DR  + EHLIFRENTLATKAIEEY++L+GQKYL+DA+GEFI+ALYES+ENCEVDP KC+A
Sbjct: 278  DRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSA 337

Query: 534  SSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASL 593
            + L EHQ NL+MCCELA CK++NS+CVFPRELKEVFASWR  C+ RGR DI++RLISASL
Sbjct: 338  ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASL 397

Query: 594  FLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFL 653
            FLRFLCPAIMSPSLF L+QEYPD++T+RTLTLIAKV QNLANF+KF SKE+++ FMN+FL
Sbjct: 398  FLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFL 457

Query: 654  ELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGP 713
            E EW +MQ+FL EISN +TL+N++ FEGYIDLGRELS+LH+LLWE + QL +  + KLGP
Sbjct: 458  EHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGP 517

Query: 714  LPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFM 773
            LPR+L D+ TAL  P   + P        P      G S+   G            +  +
Sbjct: 518  LPRILRDVHTALSTPGSGQLPGTNDLASTPG----SGSSSISAGLQ----------KMVI 563

Query: 774  ARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQK 833
               L+  +D  RLPSPT E          KDLF+V+R    + SPA  +S S+  EP+ +
Sbjct: 564  ENDLSGLIDFTRLPSPTPE---------NKDLFFVTRSSGVQPSPARSSSYSEANEPDLQ 614

Query: 834  MLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQ 893
            M +  KS+SM+DLQ      R       + A    L    QA+    +   PA A  ++ 
Sbjct: 615  MANGGKSLSMVDLQ----DARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNL 670

Query: 894  GSGSSITAAGMRLSQMGVTTDGVPAQ-QLRIPLSFQNPLFHMAADGPGPPGGHGGGG--G 950
               +++  AG   +  G T++G P + QL  PLSFQNP++ MAA  P  P G G  G  G
Sbjct: 671  AGLATVRRAGQTPTTPG-TSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEG 729

Query: 951  HGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF 1010
            H   SSH                         S SE+L++      AA +    + ++E 
Sbjct: 730  HSSLSSH-------------------------SNSEELAA------AAKLGSFSTAAEEL 758

Query: 1011 GPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQR----PAPSGPGGGSGGGSGGGGGGQPP 1066
                 +  RRQ+SL +       P Q + GPQR    P P  P               PP
Sbjct: 759  ARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPP--------------PPP 804

Query: 1067 PLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPA-RPRQQSLSKEGSIGGSGGSGGGG 1125
            P  RG++    +S  Q PRPSSG L  +     GP+ R RQQS S +G            
Sbjct: 805  PAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGD----------- 853

Query: 1126 GGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSK 1185
               LKP     H Q PS ++P   A +RT AW+  M     + E    +      ++  +
Sbjct: 854  SPELKPRAV--HKQGPSPVSPN--ALDRTAAWLLTMNAQLLEDEGLGPDPPH---RDRLR 906

Query: 1186 SMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSE 1245
            S DE     + + E+++  L+++L +S +KLEEYE     QEE T K++++YQARLE+ E
Sbjct: 907  SKDE-----LSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGE 961

Query: 1246 KRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPT 1305
            +RLR+QQ +KD Q+K II RLM VEEEL++DH  M +   + K++++DAQE+++  L   
Sbjct: 962  ERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEM-QAAVDSKQKIIDAQEKRIASLDAA 1020

Query: 1306 NPRVTLA----------PPWNGLAPPAPPPPPRLQITENGEFRNTAD 1342
            N R+  A             NG+   +P  P +LQITENGEFRN+++
Sbjct: 1021 NARLMSALTQLKERYSMQARNGI---SPTNPTKLQITENGEFRNSSN 1064


>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
          Length = 1280

 Score = 1016 bits (2627), Expect = 0.0
 Identities = 617/1370 (45%), Positives = 838/1370 (61%), Gaps = 197/1370 (14%)

Query: 17   SYAPFRDVRGPSMHRTQYVHSPY-DRPGWNPRFCIISGNQLLMLDEDEIHPLLI-RDRRS 74
            S+    DV+GP  HR     SPY +   W  ++CI++ +QL++L++++  P+   +++++
Sbjct: 62   SWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQT 121

Query: 75   ESSRNKLLRRTVSVPVEGR-----PHGEHEYHLGRSR---RKSVPGG----KQYSMEGAP 122
            +S++ + LRRTVSVP EG+     P G  +  +   R   R+S+ G     K  SM+ A 
Sbjct: 122  DSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTAN 181

Query: 123  AAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHS 182
             +PF+   GF S+RLK SIKRTKSQ KLDR +SFR  LP  RS D DR+R +   KES S
Sbjct: 182  TSPFKVP-GFFSKRLKGSIKRTKSQSKLDRNTSFR--LPSLRSTD-DRSRGLPKLKESRS 237

Query: 183  HESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKW 242
            HESLLSP S  E L+L   E   +KP+HSSILGQ+FCFEVT  SG+KCF+C SA+ERDKW
Sbjct: 238  HESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKW 297

Query: 243  IENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS 302
            +ENL+R V+PNKDN RR +NVL+LWIIEA++L PKK+Y+CELCLDD L+ARTTSK ++  
Sbjct: 298  MENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKA-- 355

Query: 303  GDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQW 362
             D +FWGEHFEF +LP + ++ +H+Y+D +KK+KKDK  YVGLV +P A++ GR F E+W
Sbjct: 356  -DNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKW 414

Query: 363  YPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAE 422
            YPV+ PT +                    KGK G P++R+K+R+QT++ILPME YKEFAE
Sbjct: 415  YPVSTPTPN--------------------KGKTGGPSIRIKSRFQTITILPMEQYKEFAE 454

Query: 423  YVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL 482
            +VT++Y MLC+VLEP ++V+ KEE+A ALVHILQSTG+AKDFL+D+ MSEVDR  E + L
Sbjct: 455  FVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVL 514

Query: 483  IFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN 542
            IFRENT+ATK+IEEY++L+GQ+YL DA+GEFI+ALYES+ENCEVDP KC++S L +HQ+N
Sbjct: 515  IFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSN 574

Query: 543  LRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAI 602
            L+MCCELA CK++NS+CVFPRELKEVFASW+ +C  RG++DI++RLISASLFLRFLCPAI
Sbjct: 575  LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAI 634

Query: 603  MSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQ 662
            MSPSLF LMQEYPD++TSRTLTLIAKVIQNLANF+KF +KE+++ FMN+FLE EWG M++
Sbjct: 635  MSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKR 694

Query: 663  FLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLNDIS 722
            FL EISN DT++N+  F+GYIDLGRELS LH+LLWEV+ QL K  + KLGPLPR+L DI+
Sbjct: 695  FLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADIT 754

Query: 723  TALRNPN-IQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLN--- 778
             +L NP  IQ+Q  R +E                        NSS ++   ++ GL    
Sbjct: 755  KSLTNPTPIQQQLRRFTEH-----------------------NSSPNVSGSLSSGLQKIF 791

Query: 779  ---SSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKML 835
               +  D+ +L SP+++         GK L  V +     SS +   S  D     +  L
Sbjct: 792  EDPTDSDLHKLKSPSQDN--TDSYFRGKTLLLVQQ----ASSQSMTYSEKD---ERESSL 842

Query: 836  SVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGS 895
               +SVS++DLQ D    ++  +SV  +  V   L  SQ S+T    ++     R +Q +
Sbjct: 843  PNGRSVSLMDLQ-DTHAAQVEHASV--MLDVPIRLTGSQLSITQVASIKQL---RETQST 896

Query: 896  GSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPS 955
              S       L        G+       PLSFQNP++H+    P  P             
Sbjct: 897  PQSAPQVRRPLHPALNQPGGLQ------PLSFQNPVYHLNNPIPAMPKASID-------- 942

Query: 956  SHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF---GP 1012
                                       S  E+LS+   +        S S S++F   GP
Sbjct: 943  ---------------------------SSLENLSTASSR--------SQSNSEDFKLSGP 967

Query: 1013 SGT---DFTRRQLSLQD-NLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGG--GGQPP 1066
            S +   DFT+R    +D + +H +    I +   R   +G         GG G     PP
Sbjct: 968  SNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPP 1027

Query: 1067 PLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGG 1126
             L    S + T S       S  +     EP    +R RQQS S   S            
Sbjct: 1028 SLPHSASLRSTGSM------SVVSAALVAEPVQNGSRSRQQSSSSRES------------ 1069

Query: 1127 GGLKPSITK-QHSQTPSTLNP----TMPASERTVAWVSNMPHLSADIESAHIEREEYKLK 1181
                P +   Q  QT    +P    TM   ERT AWV N      D+E            
Sbjct: 1070 --PVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVE------------ 1115

Query: 1182 EYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARL 1241
            E  +++DE++    ++YE+EI  LKERL +S+R+LEEYERRLL QE+Q  K+L++Y+ARL
Sbjct: 1116 ETEQNLDEAK--HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARL 1173

Query: 1242 EQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPP 1301
            E SE+RLR+QQ EKDSQ+KSII RLM VEEEL++DH  M + + + K++++DAQE+++  
Sbjct: 1174 EDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEM-QAVIDAKQKIIDAQEKRIVS 1232

Query: 1302 LGPTNPRVTLA----------PPWNGLAPPAPPPPPRLQITENGEFRNTA 1341
            L   N R+  A             NG+   +P  P +L ITENGEF+N++
Sbjct: 1233 LDSANTRLMSALTQVKERYSMQVRNGI---SPTNPTKLSITENGEFKNSS 1279


>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
          Length = 1139

 Score =  967 bits (2500), Expect = 0.0
 Identities = 592/1300 (45%), Positives = 787/1300 (60%), Gaps = 205/1300 (15%)

Query: 84   RTVSVPVEGRPHGEHEYHLGRSRRKSVPGG----KQYSMEGAPAAPFRPSQGFLSRRLKS 139
            +T  VP E  P           RR+S+ G     K  SM+ A  +PF+   GF S+RLK 
Sbjct: 2    QTPEVPAERSP-----------RRRSISGTSTSEKPNSMDTANTSPFKVP-GFFSKRLKG 49

Query: 140  SIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELN 199
            SIKRTKSQ KLDR +SFR  LP  RS D DR+R +   KES SHESLLSP S  E L+L 
Sbjct: 50   SIKRTKSQSKLDRNTSFR--LPSLRSTD-DRSRGLPKLKESRSHESLLSPCSTVECLDLG 106

Query: 200  LDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRR 259
              E   +KP+HSSILGQ+FCFEVT  SG+KCF+C SA+ERDKW+ENL+R V+PNKDN RR
Sbjct: 107  RGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRR 166

Query: 260  VDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPA 319
             +NVL+LWIIEA++L PKK+Y+CELCLDD L+ARTTSK ++   D +FWGEHFEF +LP 
Sbjct: 167  AENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKA---DNIFWGEHFEFFSLPP 223

Query: 320  VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGS 379
            + ++ +H+Y+D +KK+KKDK  YVGLV +P A++ GR F E+WYPV+ PT +        
Sbjct: 224  LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPN-------- 275

Query: 380  GGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPAL 439
                        KGK G P++R+K+R+QT++ILPME YKEFAE+VT++Y MLC+VLEP +
Sbjct: 276  ------------KGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVI 323

Query: 440  NVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMR 499
            +V+ KEE+A ALVHILQSTG+AKDFL+D+ MSEVDR  E + LIFRENT+ATK+IEEY++
Sbjct: 324  SVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLK 383

Query: 500  LIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHC 559
            L+GQ+YL DA+GEFI+ALYES+ENCEVDP KC++S L +HQ+NL+MCCELA CK++NS+C
Sbjct: 384  LVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYC 443

Query: 560  VFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQT 619
            VFPRELKEVFASW+ +C  RG++DI++RLISASLFLRFLCPAIMSPSLF LMQEYPD++T
Sbjct: 444  VFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRT 503

Query: 620  SRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSF 679
            SRTLTLIAKVIQNLANF+KF +KE+++ FMN+FLE EWG M++FL EISN DT++N+  F
Sbjct: 504  SRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGF 563

Query: 680  EGYIDLGRELSTLHALLWEVLPQLSK-------EALLKLGPLPRLLNDISTALRNPN-IQ 731
            +GYIDLGRELS LH+LLWEV+ QL K         + KLGPLPR+L DI+ +L NP  IQ
Sbjct: 564  DGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQ 623

Query: 732  RQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLN------SSMDMAR 785
            +Q  R +E                        NSS ++   ++ GL       +  D+ +
Sbjct: 624  QQLRRFTEH-----------------------NSSPNVSGSLSSGLQKIFEDPTDSDLHK 660

Query: 786  LPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLD 845
            L SP+++         GK L  V +     SS +   S  D     +  L   +SVS++D
Sbjct: 661  LKSPSQDN--TDSYFRGKTLLLVQQ----ASSQSMTYSEKD---ERESSLPNGRSVSLMD 711

Query: 846  LQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMR 905
            LQ D    ++  +SV  +  V   L  SQ S+T    ++     R +Q +  S       
Sbjct: 712  LQ-DTHAAQVEHASV--MLDVPIRLTGSQLSITQVASIKQL---RETQSTPQSAPQVRRP 765

Query: 906  LSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHH 965
            L        G+       PLSFQNP++H+    P  P                       
Sbjct: 766  LHPALNQPGGLQ------PLSFQNPVYHLNNPIPAMPKASID------------------ 801

Query: 966  HRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF---GPSGT---DFTR 1019
                             S  E+LS+   +        S S S++F   GPS +   DFT+
Sbjct: 802  -----------------SSLENLSTASSR--------SQSNSEDFKLSGPSNSSMEDFTK 836

Query: 1020 RQLSLQD-NLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGG--GGQPPPLQRGKSQQL 1076
            R    +D + +H +    I +   R   +G         GG G     PP L    S + 
Sbjct: 837  RSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRS 896

Query: 1077 TVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITK- 1135
            T S       S  +     EP    +R RQQS S   S                P +   
Sbjct: 897  TGSM------SVVSAALVAEPVQNGSRSRQQSSSSRES--------------PVPKVRAI 936

Query: 1136 QHSQTPSTLNP----TMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESR 1191
            Q  QT    +P    TM   ERT AWV N      D+E            E  +++DE++
Sbjct: 937  QRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVE------------ETEQNLDEAK 984

Query: 1192 LDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQ 1251
                ++YE+EI  LKERL +S+R+LEEYERRLL QE+Q  K+L++Y+ARLE SE+RLR+Q
Sbjct: 985  --HAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQ 1042

Query: 1252 QAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQERQLPPLGPTNPRVTL 1311
            Q EKDSQ+KSII RLM VEEEL++DH  M + + + K++++DAQE+++  L   N R+  
Sbjct: 1043 QEEKDSQMKSIISRLMAVEEELKKDHAEM-QAVIDAKQKIIDAQEKRIVSLDSANTRLMS 1101

Query: 1312 A----------PPWNGLAPPAPPPPPRLQITENGEFRNTA 1341
            A             NG+   +P  P +L ITENGEF+N++
Sbjct: 1102 ALTQVKERYSMQVRNGI---SPTNPTKLSITENGEFKNSS 1138


>gi|130502162 RAS protein activator like 3 [Homo sapiens]
          Length = 1011

 Score =  409 bits (1052), Expect = e-114
 Identities = 266/648 (41%), Positives = 362/648 (55%), Gaps = 56/648 (8%)

Query: 182 SHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDK 241
           S ESL + S     L+L  + D  I P+H S+LG+  CF+VT + G++CF+CRSAAERD+
Sbjct: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283

Query: 242 WIENLQRAVKPNKDNSRRVDNVLKLWIIEARELP------PKKRYYCELCLDDMLYARTT 295
           WIE+L+R  +P +DN  R +  L +W+ EA+ LP      P  R   EL LD  L ART 
Sbjct: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVR--AELWLDGALLARTA 341

Query: 296 SKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGY-VGLVTVPVATLA 354
             PR+  G  +FW E F F  LP  R L L L           +    +  +  P A  A
Sbjct: 342 --PRAGPGQ-LFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAA 398

Query: 355 GRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPM 414
           G    E+W+P+           +G+  G                A+R + R + + +LP 
Sbjct: 399 G---LERWFPL-----------LGAPAGA---------------ALRARIRARRLRVLPS 429

Query: 415 ELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVD 474
           E YKE AE++T HY  LC  LEPAL  + KEE+A+A+V +L++TG+A+  ++D+  +E+ 
Sbjct: 430 ERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELA 489

Query: 475 RFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTAS 534
           R   RE L+FRENTLATKAI+EYM+L+ Q YL++ +G+ +R L  S E+CEVDP KC AS
Sbjct: 490 RCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPAS 549

Query: 535 SLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLF 594
            L EHQA LR  CE     +++S+  FP EL  VF+SWR  C ERG E +  RL+ ASLF
Sbjct: 550 ELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLF 609

Query: 595 LRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLE 654
           LR LCPAI++PSLFGL  ++P    +RTLTLIAKVIQNLAN + F  KE ++GFMN FLE
Sbjct: 610 LRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLE 669

Query: 655 LEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPL 714
               +MQ FL +++ +D     S ++G  DL  +L+ LHA L  +  +L +     L PL
Sbjct: 670 EHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPL 729

Query: 715 PRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSA-EMQGYMM-RDLNSSIDL--Q 770
           P +L  I      P +   P R    P P   V    SA E  G++  RDL     L  +
Sbjct: 730 PTILRAIEEG--QPVLVSVPMR---LPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISK 784

Query: 771 SFMARGLNSSMDMARLPSPTKEKP-PPPPPGGGKDLFYVSRPPLARSS 817
           S   R +  S   AR P P +E+P   P P        V RP   R S
Sbjct: 785 SQSLRSVRRSESWAR-PRPDEERPLRRPRPVQRTQSVPVRRPARRRQS 831


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score =  150 bits (378), Expect = 1e-35
 Identities = 129/506 (25%), Positives = 234/506 (46%), Gaps = 53/506 (10%)

Query: 209  VHSSILGQEFCFEVTTSSGTK-----CFACRSAAERDKWIENLQ-----RAVKPNKDNSR 258
            VH S+ G+  CF++     ++      FA  +  + + W++ LQ     R   P   N R
Sbjct: 530  VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589

Query: 259  -RVDNVLKLWIIEARELPPKK--RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFN 315
             R  + L L I EA +LP K     YC + L+ +  A+T ++     G    W E F F+
Sbjct: 590  LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR----EGQNPVWSEEFVFD 645

Query: 316  NLPA-VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGS 374
            +LP  +    + L      K KK K   +  +   ++ L   H T++W+   L +     
Sbjct: 646  DLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWF---LLSSHIPL 698

Query: 375  GGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAV 434
             G+  G                  ++R++ARY    I+P E Y EF E +      +   
Sbjct: 699  KGIEPG------------------SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYA 740

Query: 435  LEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL-IFRENTLATKA 493
            L    +V G++    A + +     +  + L    +++ +  ME E   +FR  TLA+  
Sbjct: 741  LS---HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTL 797

Query: 494  IEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN--LRMCCELAL 551
            +E+YM+    +++  A+ + I  + ES+++CE+ P K   +          L +  EL  
Sbjct: 798  MEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE 857

Query: 552  CKVVNSHCVFPRELKEVFASWRLRCAERGRED--IADRLISASLFLRFLCPAIMSPSLFG 609
             K+  +  + P  L+ ++   +     +   +  +  R++S  +FLR +CPAI++P +F 
Sbjct: 858  -KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFN 916

Query: 610  LMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN 669
            ++ + P    +RTL L+AK +QNLAN  +F +KE ++  +N F++     M  FL E+ N
Sbjct: 917  IISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGN 976

Query: 670  LDTLTNSSSFEGYIDLGRELSTLHAL 695
            +  L +++      DL R+L+ LH +
Sbjct: 977  VPELPDTTE-HSRTDLSRDLAALHEI 1001


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score =  150 bits (378), Expect = 1e-35
 Identities = 129/506 (25%), Positives = 234/506 (46%), Gaps = 53/506 (10%)

Query: 209 VHSSILGQEFCFEVTTSSGTK-----CFACRSAAERDKWIENLQ-----RAVKPNKDNSR 258
           VH S+ G+  CF++     ++      FA  +  + + W++ LQ     R   P   N R
Sbjct: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412

Query: 259 -RVDNVLKLWIIEARELPPKK--RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFN 315
            R  + L L I EA +LP K     YC + L+ +  A+T ++     G    W E F F+
Sbjct: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR----EGQNPVWSEEFVFD 468

Query: 316 NLPA-VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGS 374
           +LP  +    + L      K KK K   +  +   ++ L   H T++W+   L +     
Sbjct: 469 DLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWF---LLSSHIPL 521

Query: 375 GGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAV 434
            G+  G                  ++R++ARY    I+P E Y EF E +      +   
Sbjct: 522 KGIEPG------------------SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYA 563

Query: 435 LEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL-IFRENTLATKA 493
           L    +V G++    A + +     +  + L    +++ +  ME E   +FR  TLA+  
Sbjct: 564 LS---HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTL 620

Query: 494 IEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN--LRMCCELAL 551
           +E+YM+    +++  A+ + I  + ES+++CE+ P K   +          L +  EL  
Sbjct: 621 MEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE 680

Query: 552 CKVVNSHCVFPRELKEVFASWRLRCAERGRED--IADRLISASLFLRFLCPAIMSPSLFG 609
            K+  +  + P  L+ ++   +     +   +  +  R++S  +FLR +CPAI++P +F 
Sbjct: 681 -KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFN 739

Query: 610 LMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN 669
           ++ + P    +RTL L+AK +QNLAN  +F +KE ++  +N F++     M  FL E+ N
Sbjct: 740 IISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGN 799

Query: 670 LDTLTNSSSFEGYIDLGRELSTLHAL 695
           +  L +++      DL R+L+ LH +
Sbjct: 800 VPELPDTTE-HSRTDLSRDLAALHEI 824


>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
          Length = 834

 Score =  125 bits (315), Expect = 2e-28
 Identities = 115/406 (28%), Positives = 187/406 (46%), Gaps = 51/406 (12%)

Query: 287 DDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLV 346
           D++ Y   T +P S S  + F  E  + + L     +R+ L+  S+ K   +   ++G +
Sbjct: 195 DEVFYFEVT-RPCSYSKKSHFDFEEEDVDKLE----IRVDLWNASNLKFGDE---FLGEL 246

Query: 347 TVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARY 406
            +P+  L      E WY   L     GS  +     G               ++RL   Y
Sbjct: 247 RIPLKVLRQSSSYEAWY--FLQPRDNGSKSLKPDDLG---------------SLRLNVVY 289

Query: 407 QTMSILPMELYKEFAEYVTNHYRMLCAVLEP----ALNVKG-----KEEVASALVHILQS 457
               +   + Y    + +     +  A +EP    A ++ G     K+E A  LV +   
Sbjct: 290 TEDHVFSSDYYSPLRDLL-----LKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLH 344

Query: 458 TGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRAL 517
            G+   F+S +A +EV R  +  + IFR N+LA+K I+E M+L G  YL   +   I  +
Sbjct: 345 YGRVVPFISAIASAEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEI 403

Query: 518 YESEENCEVDPIKCT-ASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRC 576
            +S + CE+DP+K     +L  +  NLR   +     +  S    P  + ++F S R   
Sbjct: 404 CQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAA 463

Query: 577 AERGRED--IADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLA 634
           A+R ++D  +    +S+ +FLRF  PAI+SP+LF L   + D QTSRTLTLI+K +Q L 
Sbjct: 464 AKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG 523

Query: 635 NFSKFTS---KEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSS 677
           + SK  S   KE ++    EF      + Q++   + N   L +SS
Sbjct: 524 SLSKSKSASFKESYMATFYEFF-----NEQKYADAVKNFLDLISSS 564


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score =  115 bits (289), Expect = 2e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 63  LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 120 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 168

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 169 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 218

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 219 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 277

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 447


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score =  115 bits (289), Expect = 2e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 350 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score =  115 bits (289), Expect = 2e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 63  LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 120 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 168

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 169 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 218

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 219 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 277

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 447


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score =  115 bits (289), Expect = 2e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 350 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score =  115 bits (287), Expect = 4e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 350 KSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score =  115 bits (287), Expect = 4e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191

Query: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240

Query: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290

Query: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349

Query: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 350 KSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409

Query: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469

Query: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519


>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
          Length = 849

 Score =  112 bits (281), Expect = 2e-24
 Identities = 101/354 (28%), Positives = 167/354 (47%), Gaps = 34/354 (9%)

Query: 342 YVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVR 401
           ++G + VPV  L      + WY +  P  +G         G                ++R
Sbjct: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLG----------------SLR 310

Query: 402 LKARYQTMSILPMELYKEFAEYVTNH--YRMLCAVLEPALN--VKGKEEVASALVHILQS 457
           L   Y    +LP E Y      +      + + A     L+   + K +    LV +L  
Sbjct: 311 LNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLH 370

Query: 458 TGKAKDFLSDMAMSEVD-RFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRA 516
             K   F +  A++E+D +  +  + IFR N+LAT+ ++E M+++G  YLK  +   +  
Sbjct: 371 HDKLVPFAT--AVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDE 428

Query: 517 LYESEENCEVDPIKCTASSLAEH-QANLRMCCELALCKVVNSHCVFPRELKEVFASWRLR 575
           + +S ++CE+DPIK       E+ + NLR   +     +V S    P  + ++F S R  
Sbjct: 429 ICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQM 488

Query: 576 CAERGRED--IADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNL 633
             +R   D  +    +S+ +FLRF   A++SP  F L   +PD QT RTLTLI+K IQ L
Sbjct: 489 ATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTL 548

Query: 634 ANFSKFT-SKEDFL-GFMNEFLEL--EWG---SMQQFLYEISNLDTLTNSSSFE 680
            ++   + SK  F   FM EF ++  E G   ++++FL EIS+ +T  +S + E
Sbjct: 549 GSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score =  108 bits (270), Expect = 3e-23
 Identities = 113/444 (25%), Positives = 192/444 (43%), Gaps = 65/444 (14%)

Query: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTV------FWGEHFEFNNL 317
           L+  ++ AR+L P+     ++      +AR     +S    T+       W E  E   +
Sbjct: 135 LRCHVLHARDLAPR-----DISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREM 189

Query: 318 P-AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGG 376
           P A   LR+ L+ D D   K D   ++G+V     TL  +     +  +  P     SGG
Sbjct: 190 PGAPSPLRVELW-DWDMVGKND---FLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGG 245

Query: 377 MGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYR------- 429
                                 A+R+K R     +LP + Y+   E +    +       
Sbjct: 246 -------------------NLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDT 286

Query: 430 -MLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENT 488
               A+LE       ++++A+ LV +    G A  FL  +   EV R M+  + +FR N+
Sbjct: 287 ASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRSNS 345

Query: 489 LATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTAS---------SLAEH 539
           LA+K++E++M+L+G  YL + +   I  ++E ++  E+DP K             +L+E 
Sbjct: 346 LASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEE 405

Query: 540 QANLRMCCELA------LCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLI 589
           Q        L       +  +V S    P  ++  F     R  ER      +D+    I
Sbjct: 406 QMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAI 465

Query: 590 SASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSK--FTSKEDFLG 647
           S  LFLRF  PAI++P LF L  ++ D QTSR+L L+AK +Q++ N  +     KE ++ 
Sbjct: 466 SGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMA 525

Query: 648 FMNEFLELEWGSMQQFLYEISNLD 671
            ++ FL      ++ FL  + ++D
Sbjct: 526 PLHPFLLQCVSRVRDFLDRLVDVD 549


>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
          Length = 2818

 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 78/262 (29%), Positives = 136/262 (51%), Gaps = 16/262 (6%)

Query: 445  EEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQK 504
            +E+A  LV +  S       L +M   EV+   +    +FR N+LA+K +    ++ G  
Sbjct: 1237 DELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNSLASKIMTFCFKVYGAT 1295

Query: 505  YLKDAIGEFIRALYESEE----NCEVDPIKCTAS-SLAEHQANLRMCCELALCKVVNSHC 559
            YL+  +   +R +  S +    + EVDP +   S SL E+Q NL    E     +++S  
Sbjct: 1296 YLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSS 1355

Query: 560  VFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQT 619
             FP +L+ V        ++R  ++    + SA +FLRF+ PAI+SP   G++ + P  + 
Sbjct: 1356 EFPPQLRSVCHCLYQVVSQRFPQNSIGAVGSA-MFLRFINPAIVSPYEAGILDKKPPPRI 1414

Query: 620  SRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN----LDTLTN 675
             R L L++K++Q++AN   FT KE+ +   N+F++  + + ++F  +I++     D + +
Sbjct: 1415 ERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNH 1473

Query: 676  SSSFEGYIDLGRELSTLHALLW 697
            S SF   I  G  L+ LH LLW
Sbjct: 1474 SLSF---ISDGNVLA-LHRLLW 1491


>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
          Length = 2839

 Score = 91.3 bits (225), Expect = 6e-18
 Identities = 78/282 (27%), Positives = 139/282 (49%), Gaps = 35/282 (12%)

Query: 445  EEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQK 504
            +E+A  LV +  S       L +M   EV+   +    +FR N+LA+K +    ++ G  
Sbjct: 1237 DELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNSLASKIMTFCFKVYGAT 1295

Query: 505  YLKDAIGEFIRALYESEE----NCEVDPIKCTAS-SLAEHQANLRMCCELALCKVVNSHC 559
            YL+  +   +R +  S +    + EVDP +   S SL E+Q NL    E     +++S  
Sbjct: 1296 YLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSS 1355

Query: 560  VFPRELKEV-FASWRLRC------------AERGREDIADRL-------ISASLFLRFLC 599
             FP +L+ V    ++  C             E  +  ++ R        + +++FLRF+ 
Sbjct: 1356 EFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFIN 1415

Query: 600  PAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGS 659
            PAI+SP   G++ + P  +  R L L++K++Q++AN   FT KE+ +   N+F++  + +
Sbjct: 1416 PAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLFT-KEEHMRPFNDFVKSNFDA 1474

Query: 660  MQQFLYEISN----LDTLTNSSSFEGYIDLGRELSTLHALLW 697
             ++F  +I++     D + +S SF   I  G  L+ LH LLW
Sbjct: 1475 ARRFFLDIASDCPTSDAVNHSLSF---ISDGNVLA-LHRLLW 1512


>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sapiens]
          Length = 479

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 11/170 (6%)

Query: 1132 SITKQHSQTPSTLNPTMPASERTVAWVSNMP-HLSADIESAHIERE-EYKLKEYSKSMDE 1189
            S+ K  +QT   L P  PA    V  + +   HL  ++ES   + + E +  +    ++ 
Sbjct: 136  SLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNR 195

Query: 1190 SRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLR 1249
             + +R++E EE +H  +ERLH    +L E E RL  QEE+    L + + RL + E+RL 
Sbjct: 196  RQEERLREQEERLHEQEERLHEQEERLCEQEERLCEQEER----LREQEERLREQEERLH 251

Query: 1250 QQQAEKDSQIKSIIGRLMLVEEEL-RRDHPAMAEPLPEPKKRLLDAQERQ 1298
            +Q+     Q +    RL   EE L  ++     E L E  ++LL+ + RQ
Sbjct: 252  EQEERLCEQEE----RLCEQEERLCEQEKLPGQERLLEEVEKLLEQERRQ 297



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 6/98 (6%)

Query: 1176 EEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILM 1235
            +E +L E  + + E   +R++E EE +H  +ERL     +L E E RL  QE+     L 
Sbjct: 225  QEERLCEQEERLREQE-ERLREQEERLHEQEERLCEQEERLCEQEERLCEQEK-----LP 278

Query: 1236 QYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEEL 1273
              +  LE+ EK L Q++ +++ +      RL+   EEL
Sbjct: 279  GQERLLEEVEKLLEQERRQEEQERLLERERLLDEVEEL 316



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 36/145 (24%), Positives = 65/145 (44%), Gaps = 26/145 (17%)

Query: 1169 ESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNR------------KL 1216
            +   +  +E +L+E  + + E   +R+ E EE +   +ERL    +            KL
Sbjct: 232  QEERLREQEERLREQEERLHEQE-ERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKL 290

Query: 1217 EEYERRLLSQEE--QTSKIL-----MQYQARLEQSEKRLRQQQAEKD-SQIKSI-----I 1263
             E ERR   QE   +  ++L     +  Q RL Q ++RL QQ+  ++  +++ +     +
Sbjct: 291  LEQERRQEEQERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLREL 350

Query: 1264 GRLMLVEEELRRDHPAMAEPLPEPK 1288
             RL  +E  L     A+ E   EP+
Sbjct: 351  ERLRELERMLELGWEALYEQRAEPR 375


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 76/288 (26%), Positives = 93/288 (32%), Gaps = 112/288 (38%)

Query: 937  DGPGPPGGHGGG-------GGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLS 989
            DGP PP    G         G  PP+ HH  HHHHHH    PP     P H ++      
Sbjct: 971  DGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHH--APPP----QPHHHHAHP---- 1020

Query: 990  SGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQ------- 1042
               P PP            E G S  D                 PP++ +GPQ       
Sbjct: 1021 ---PHPPEM----------ETGGSPDD----------------PPPRLALGPQPSLRGWR 1051

Query: 1043 ----RPAPSGPGGGSGGGSGGGGG-GQPPPLQ--------------------RGKSQQLT 1077
                 P P  P     G +GGGGG  Q P L+                    RG+   L 
Sbjct: 1052 GGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLV 1111

Query: 1078 VSAAQKPRPSSGNLL---------QSPEPSYGPARPRQQS-------LSKEGSIGGSGGS 1121
                 +  P  G  L          SP+P    A P +++       + K  S   SG S
Sbjct: 1112 KQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRS 1171

Query: 1122 -----------------GGGGGGGLKPSITKQHSQTPSTLNPT-MPAS 1151
                             GGGGGGG  PS     S  P + +P   PAS
Sbjct: 1172 SQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPAS 1219



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 37/126 (29%), Positives = 48/126 (38%), Gaps = 16/126 (12%)

Query: 1011 GPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQR 1070
            GP GT  T     L+ N    ++ P   +     AP     G+ G + G  G   P    
Sbjct: 422  GPPGTGLTVPPALLRANSDTSMALPDWMVFS---APGAASSGAPGPTSGSQGQSQPSAPT 478

Query: 1071 GKSQQLTVSAAQKPRPSSGNLLQSPEPSYGP--------ARPRQQSLSKEGSIGGSGGSG 1122
             K    T+ +A  PR   G   +SP     P         RP      +EG  GG+GGS 
Sbjct: 479  TKLSSGTLRSASSPR---GARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGS- 534

Query: 1123 GGGGGG 1128
             GG GG
Sbjct: 535  -GGPGG 539



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 36/123 (29%), Positives = 51/123 (41%), Gaps = 9/123 (7%)

Query: 1012 PSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRG 1071
            P GTD    ++  + +  H L    I+      + S  GGGS GG GG G G    +  G
Sbjct: 1668 PPGTDSGIEEVDSRSSSDHPLET--ISSASTLSSLSAEGGGSAGGGGGAGAG----VASG 1721

Query: 1072 KSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKP 1131
                 T  A    +   G+   +P P Y P       L +  ++G SGG   G  GGL+ 
Sbjct: 1722 PELLDTYVAYLDGQAFGGS--STPGPPYPPQLMTPSKL-RGRALGASGGLRPGPSGGLRD 1778

Query: 1132 SIT 1134
             +T
Sbjct: 1779 PVT 1781



 Score = 38.1 bits (87), Expect = 0.057
 Identities = 104/443 (23%), Positives = 147/443 (33%), Gaps = 67/443 (15%)

Query: 710  KLGPLPRLLNDISTAL-RNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDLNSSID 768
            K G LP   +  S A  + P     PS ++  P P  ++++ PS    G   +  ++  +
Sbjct: 1122 KGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPT-IIIKAPSTSSSGRSSQGSSTEAE 1180

Query: 769  LQSFM-----ARGLNSSMDMARLPSPTKEKPPPPP----PGGGKDLFYVSRPPLARSSPA 819
              +         G  SS   A   SP    P P P    P G   L + S+   A    A
Sbjct: 1181 PPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAA 1240

Query: 820  YCTSSSDITEPEQKMLSVNKSVSMLDLQGDG-------PGGRLNSSSV--SNLAAVGDLL 870
                        +  L ++      D  GDG       PG RL  S      + +    L
Sbjct: 1241 RREGGWQNEARRRSTLFLSTDAGDED-GGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYL 1299

Query: 871  HSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGV---PAQQLRIPLSF 927
                A   A  G   A +     G GSS   + +    +     G    PA  L + L+ 
Sbjct: 1300 RLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAA 1359

Query: 928  QNPLFHMAADG---PGPPGGHGGGGGHGPPSSHHHHHHHHHHR-----GGEPPGDTFAPF 979
            +      +++G   P PP          PP + HHH  H HH       G  P D     
Sbjct: 1360 RERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRE 1419

Query: 980  HGY-----SKSEDLSSGVPKPPAA--SILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHM- 1031
             GY     S+ + L +    PPAA  S+LH    +      G      QL  +    H  
Sbjct: 1420 LGYRAGLGSQEKSLPA---SPPAARRSLLHRLPPT----APGVGPLLLQLGTEPPAPHPG 1472

Query: 1032 LSPPQITIGPQRP-------------APSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTV 1078
            +S P  +  P+ P              P  P     G     G G PPP  R    +   
Sbjct: 1473 VSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPR----RSVP 1528

Query: 1079 SAAQKPRPSSGN---LLQSPEPS 1098
             +   PR S  N   LL  P P+
Sbjct: 1529 PSPTSPRASEENGLPLLVLPPPA 1551



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 64/274 (23%), Positives = 81/274 (29%), Gaps = 39/274 (14%)

Query: 881  LGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPG 940
            L L P P+ R  +G G S T      S  G    G  + Q      FQ P    AA    
Sbjct: 1039 LALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLP--PRAASAAM 1096

Query: 941  PPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASI 1000
                  G G  GP              GG PP  +             S   P+PP A  
Sbjct: 1097 YVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPS-----------PTSPASPQPPPAVA 1145

Query: 1001 LHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGG 1060
              S   S    P  T   +   +         S  +    P +P P+G         GGG
Sbjct: 1146 APSEKNSI---PIPTIIIKAPSTSSSGRSSQGSSTEAE-PPTQPEPTG--------GGGG 1193

Query: 1061 GGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPA--------------RPRQ 1106
            GG  P P         + S    P   SG         +G A                R+
Sbjct: 1194 GGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRR 1253

Query: 1107 QSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQT 1140
             +L      G   G  GG G G  P    +HS++
Sbjct: 1254 STLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKS 1287



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 85/377 (22%), Positives = 122/377 (32%), Gaps = 107/377 (28%)

Query: 787  PSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDL 846
            P+P    PP PPP             +A + P   +++S +T  + ++ ++ +  S    
Sbjct: 1596 PAPATPLPPVPPPA------------VAAAPPTLDSTASSLTSYDSEVATLTQGAS---- 1639

Query: 847  QGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRL 906
                             AA GD       +  A     P P      G+ S I     R 
Sbjct: 1640 -----------------AAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRS 1682

Query: 907  SQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHH 966
            S         P + +    S  + L  ++A+G G  GG GGG G G  S       +  +
Sbjct: 1683 SS------DHPLETI----SSASTLSSLSAEGGGSAGG-GGGAGAGVASGPELLDTYVAY 1731

Query: 967  RGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQD 1026
              G+  G +  P            G P PP   +  S       G SG         L+ 
Sbjct: 1732 LDGQAFGGSSTP------------GPPYPPQL-MTPSKLRGRALGASG--------GLRP 1770

Query: 1027 NLQHMLSPPQITIGPQRPAPSGPGGG----------SGGGSGGGGGG------QPPPLQR 1070
                 L  P   + P  P  S  G G          SG  + G  GG      + PP+  
Sbjct: 1771 GPSGGLRDP---VTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPL 1827

Query: 1071 GKSQQLTVSAAQKPRPSSGNLLQSPEPSYGP-ARPRQQSL------------SKEGSIGG 1117
              +  L     +K  P        P P  GP A+P+  +L            SK    GG
Sbjct: 1828 PTASSL----PRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGG 1883

Query: 1118 SGGSGG------GGGGG 1128
            S  +GG      GG GG
Sbjct: 1884 SSAAGGALPWARGGSGG 1900



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 40/159 (25%), Positives = 53/159 (33%), Gaps = 43/159 (27%)

Query: 1003 SHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITI------GPQRPAPSGPGGGSGGG 1056
            SH     + P  T   +RQ    D+   +LS P  ++       P  P P+G G      
Sbjct: 1904 SHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAA 1963

Query: 1057 SGGGGGG--------------------QPPPLQRGKSQQLTVSAAQK----PRPSSGNLL 1092
            +  G                       +PP L+R  S  L  ++  K    PRPSS  +L
Sbjct: 1964 AAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPIL 2023

Query: 1093 QSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKP 1131
             S     GP  P        G     G   GG GG   P
Sbjct: 2024 PS-----GPLYP--------GLFDIRGSPTGGAGGSADP 2049


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 58/199 (29%), Positives = 93/199 (46%), Gaps = 41/199 (20%)

Query: 1132 SITKQHSQTPSTLNPTMPASERTVAWVSNMP-HLSADIES------AHIE---------- 1174
            S+ K  +QT   L P  PA    V  + +   HL  ++ES      A +E          
Sbjct: 136  SLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNR 195

Query: 1175 REEYKLKEYSKSM---------DESRL----DRVKEYEEEIHSLKERLHMSNRKLEEYER 1221
            R+E +L+E  + +          E RL    +R++E EE +   +ERL     +L E+E 
Sbjct: 196  RQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEE 255

Query: 1222 RLLSQEEQTSKILMQYQARLEQSEKRLRQQQ---AEKDSQIKSIIGRLMLVEEELRRDHP 1278
            RL  QEE+    L + + RL + E+RL +Q+    E++ +++    RL   EE LR    
Sbjct: 256  RLCEQEER----LCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQE- 310

Query: 1279 AMAEPLPEPKKRLLDAQER 1297
               E L E ++RL + +ER
Sbjct: 311  ---ERLCEQEERLREQEER 326



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 43/130 (33%), Positives = 71/130 (54%), Gaps = 21/130 (16%)

Query: 1176 EEYKLKEYSKSM--DESRL----DRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQ 1229
            +E +L+E+ + +   E RL    +R++E EE +H  +ERL     +L E E RL  QEE+
Sbjct: 246  QEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEER 305

Query: 1230 TSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKK 1289
                L + + RL + E+RLR+Q+ E+  + + + G+  L+EE          E L E ++
Sbjct: 306  ----LREQEERLCEQEERLREQE-ERLCEQEKLPGQERLLEE---------VEKLLEQER 351

Query: 1290 RLLDAQERQL 1299
            R  + QER L
Sbjct: 352  R-QEEQERLL 360



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 11/121 (9%)

Query: 1176 EEYKLKEYSKSMDESRLDRVKEYEEEIHSLK-----ERLHMSNRKLEEYERRLLSQEE-- 1228
            +E +L+E  + + E   +R++E EE +   +     ERL     KL E ERR   QE   
Sbjct: 302  QEERLREQEERLCEQE-ERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLL 360

Query: 1229 QTSKILMQYQARLEQSEKRLRQQQAEK-DSQIKSIIGRLMLVEEELRRDHPAMAEPLPEP 1287
            +  ++L + +  LEQ  +RLRQQ       +    + RL  +E  L     A+ E   EP
Sbjct: 361  ERERLLEEVEELLEQ--ERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQRAEP 418

Query: 1288 K 1288
            +
Sbjct: 419  R 419


>gi|4507955 YY1 transcription factor [Homo sapiens]
          Length = 414

 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 58/212 (27%), Positives = 70/212 (33%), Gaps = 71/212 (33%)

Query: 937  DGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPP 996
            D  G  G HGGGGGHG    HHHHHHHHHH    PP     P             V   P
Sbjct: 51   DEDGGGGDHGGGGGHGHAGHHHHHHHHHHH----PPMIALQPL------------VTDDP 94

Query: 997  AASILHSH-------SYSDEFGPSGTDFTRRQLSLQDNLQHMLSPP------QITIGPQR 1043
                +H H       +  +  G   +D  R +   +D +   +  P       I      
Sbjct: 95   TQ--VHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVT 152

Query: 1044 PAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPAR 1103
             A +G  GG G  S GGG                       R   G   +S + SY    
Sbjct: 153  VAAAGKSGGGGSSSSGGG-----------------------RVKKGGGKKSGKKSY---- 185

Query: 1104 PRQQSLSKEGSIGGSGGSGGGGGGGLKPSITK 1135
                          SGG+G  GGGG  P   K
Sbjct: 186  -------------LSGGAGAAGGGGADPGNKK 204



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 31/102 (30%), Positives = 40/102 (39%), Gaps = 18/102 (17%)

Query: 330 DSDKKRKKDKAGYVGLVTVPVATLAGRH--FTEQWYPVTLPTGSGGSGGMGSGGGG---- 383
           DSD  R +D  G+   + +PV   AG    + EQ        G  G GG  S GGG    
Sbjct: 117 DSDGLRAED--GFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKK 174

Query: 384 GSG----------GGSGGKGKGGCPAVRLKARYQTMSILPME 415
           G G          GG+G  G GG      K   + + I  +E
Sbjct: 175 GGGKKSGKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLE 216


>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 [Homo
            sapiens]
          Length = 2191

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 63/246 (25%), Positives = 78/246 (31%), Gaps = 75/246 (30%)

Query: 953  PPSSHHHHHHHHHHR--------------------------------------------- 967
            PP   HHHHHH HH                                              
Sbjct: 21   PPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNN 80

Query: 968  ------GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF-----GPSG 1014
                  GG P PG D   P HG +K +  + G   PP   +L      D+       P+G
Sbjct: 81   SLGGAGGGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAG 139

Query: 1015 TDFTRRQLSLQDNLQHMLSPPQITIGP------------QRPAPSGPGGGSGGGSGGGGG 1062
              +    L      Q  ++ P    GP              PA  GPGG +G      GG
Sbjct: 140  GRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGG 199

Query: 1063 GQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSG 1122
             Q P    G     + SAA    P S + LQ+    Y  ++            GG GG G
Sbjct: 200  QQSP----GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGG 255

Query: 1123 GGGGGG 1128
            GGGGGG
Sbjct: 256  GGGGGG 261



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 69/249 (27%), Positives = 84/249 (33%), Gaps = 77/249 (30%)

Query: 951  HGPPSSHHHHHH----HHHHR--------------------------------------- 967
            H    +HHHHHH    HHHH                                        
Sbjct: 27   HHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAG 86

Query: 968  GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGP-----SGTDFTRR 1020
            GG P PG D   P HG +K +  + G   PP   +L      D+  P     +G  +   
Sbjct: 87   GGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHP 145

Query: 1021 QLSLQDNLQHMLSPPQITIGPQR------------PAPSGPGGGSGGGSGGGGGGQPPPL 1068
             L      Q  ++ P    GP              PA  GPGG +G      GG Q P  
Sbjct: 146  GLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-- 203

Query: 1069 QRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY---------GPARPRQQSLSKEGSIGGSG 1119
              G     + SAA    P S + LQ+    Y         G +RP        G  GG G
Sbjct: 204  --GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGG-GGGG 260

Query: 1120 GSGGGGGGG 1128
            GSGGGGGGG
Sbjct: 261  GSGGGGGGG 269



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 69/268 (25%), Positives = 92/268 (34%), Gaps = 28/268 (10%)

Query: 872  SSQASLTAALGLRPAPAGRLSQGS--GSSITAAGMR--------LSQMGVTTDGVPAQQL 921
            S+  SL  A G  P P   + Q    G+  +AAG +        LS+ G   D  P    
Sbjct: 77   SNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGE 136

Query: 922  RIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHG 981
                 +++P          P    GGGGG       ++++       G P G     F  
Sbjct: 137  PAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 982  YSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGP 1041
            +        G  + P   ++HS S +    P   D  +       N Q    P     G 
Sbjct: 197  H--------GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-----GY 243

Query: 1042 QRPAPSGPGGGSGGGSG--GGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
             RP   G GGG GGG G  GGGGG       G       +AA     ++G         Y
Sbjct: 244  SRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGG---GGGGGY 300

Query: 1100 GPARPRQQSLSKEGSIGGSGGSGGGGGG 1127
            G +      LS     GG    G GGGG
Sbjct: 301  GGSSAGYGVLSSPRQQGGGMMMGPGGGG 328



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 21/33 (63%), Positives = 22/33 (66%)

Query: 363 YPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKG 395
           YP     G+GG GG G GGGGGSGGG GG G G
Sbjct: 240 YPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 19/30 (63%), Positives = 19/30 (63%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G GG GG G GGG G GGG GG G GG  A
Sbjct: 249 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGA 278



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/36 (58%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 370 GSGGSGGMGSGGGGGSGG-GSGGKGKGGCPAVRLKA 404
           G GG GG GSGGGGG GG G+GG G G   A    A
Sbjct: 253 GGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAA 288



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 19/35 (54%), Positives = 19/35 (54%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKA 404
           G GG GG G G GGG GGG  G G  G  AV   A
Sbjct: 251 GGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAA 285



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 17/27 (62%), Positives = 18/27 (66%)

Query: 373 GSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G+GG G GGGGG GG  GG G GG  A
Sbjct: 247 GAGGGGGGGGGGGGGSGGGGGGGGAGA 273



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 83/347 (23%), Positives = 127/347 (36%), Gaps = 45/347 (12%)

Query: 786  LPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLD 845
            LPS ++++  P      +     S+PPLA   P +     ++ + E+     + S S+ D
Sbjct: 572  LPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNH--EDLNLIQQERPSSLPDLSGSIDD 629

Query: 846  LQGDGPGGRLNS--SSVSNLAAVGDLLHSSQASLTAAL---------GLRPAPAGR---L 891
            L   G    L+S  S+  + ++ GD  + +Q+  +            G  P+P G     
Sbjct: 630  LP-TGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGS 688

Query: 892  SQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFH----MAADGPGPPGGHGG 947
            +Q     I+ A +  SQM     G  ++    P   Q+P+      MA     P     G
Sbjct: 689  NQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYG 748

Query: 948  GGGHGPPSSHHHHHHHHHHRG-----GEPPGDTFAP-FHGYSKSEDLSSGVPKPPAASIL 1001
                GP  S H       H G           T+ P    Y    + S    +PPA S +
Sbjct: 749  PQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS----RPPAYSGV 804

Query: 1002 HSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPP---QITIGPQ-RPAPSG-----PGGG 1052
             S SYS   GP        Q+  Q   Q   + P     + G Q RP P       P   
Sbjct: 805  PSASYSGP-GPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSP 863

Query: 1053 SGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
                 GG G G P P    K+Q+   +  Q    ++ N  QS + S+
Sbjct: 864  GMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ----AAANSAQSRQGSF 906



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 56/240 (23%), Positives = 74/240 (30%), Gaps = 55/240 (22%)

Query: 939  PGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAA 998
            PG  GG GGGGG G  S            GG   G   A   G       ++      AA
Sbjct: 246  PGAGGGGGGGGGGGGGSG-----------GGGGGGGAGAGGAGAGAVAAAAA------AA 288

Query: 999  SILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGS----- 1053
            +          +G S   +             +LS P+   G     P G G  S     
Sbjct: 289  AAAAGGGGGGGYGGSSAGYG------------VLSSPRQQGGGMMMGPGGGGAASLSKAA 336

Query: 1054 -GGGSGG----GGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQS 1108
             G  +GG     G  Q P        QL  S +   R   G+  +   PS  P  P Q  
Sbjct: 337  AGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQ 396

Query: 1109 LSKEGSIGGSGGSGGGGGGGLKPSITKQH----------------SQTPSTLNPTMPASE 1152
                 +   +GG     G GL   +  Q+                + +P T  PTM  S+
Sbjct: 397  SQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQ 456



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 47/207 (22%), Positives = 65/207 (31%), Gaps = 45/207 (21%)

Query: 950  GHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDE 1009
            G  P +  H  HHHHHH          A  H +              A  + H H+   +
Sbjct: 15   GEAPAAPPHQQHHHHHH----------AHHHHHH-------------AHHLHHHHALQQQ 51

Query: 1010 FGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPG-GGSGGGSGGGGGGQPPPL 1068
                   F ++Q   Q   Q            Q P  +    GG+GGG+   G     P 
Sbjct: 52   L----NQFQQQQQQQQQQQQQQQQ-------QQHPISNNNSLGGAGGGAPQPGPDMEQPQ 100

Query: 1069 QRGKSQQLTVSAAQKPRP----SSGNLLQSPEPSYGPARPRQQSLSKEGSIGGS----GG 1120
              G         A  P P      G+   +P     PA  R +     G++G        
Sbjct: 101  HGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGL-GALGTQQPPVAV 159

Query: 1121 SGGGGGGGLKPSITKQH-SQTPSTLNP 1146
             GGGGG    P     + S  P++  P
Sbjct: 160  PGGGGGPAAVPEFNNYYGSAAPASGGP 186



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 16/38 (42%), Positives = 20/38 (52%)

Query: 359 TEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396
           + + YP +      G    G+GGGGG GGG GG   GG
Sbjct: 228 SHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGG 265



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 17/43 (39%), Positives = 18/43 (41%), Gaps = 17/43 (39%)

Query: 370 GSGGSGGMGSGG-----------------GGGSGGGSGGKGKG 395
           G GG GG G+GG                 GGG GGG GG   G
Sbjct: 264 GGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAG 306



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 17/44 (38%), Positives = 19/44 (43%), Gaps = 13/44 (29%)

Query: 369 TGSGGSGGMGSGGGGGSG-------------GGSGGKGKGGCPA 399
           +G GG GG    GG G+G             GG GG G GG  A
Sbjct: 262 SGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSA 305


>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 [Homo
            sapiens]
          Length = 2231

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 63/246 (25%), Positives = 78/246 (31%), Gaps = 75/246 (30%)

Query: 953  PPSSHHHHHHHHHHR--------------------------------------------- 967
            PP   HHHHHH HH                                              
Sbjct: 21   PPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNN 80

Query: 968  ------GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF-----GPSG 1014
                  GG P PG D   P HG +K +  + G   PP   +L      D+       P+G
Sbjct: 81   SLGGAGGGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAG 139

Query: 1015 TDFTRRQLSLQDNLQHMLSPPQITIGP------------QRPAPSGPGGGSGGGSGGGGG 1062
              +    L      Q  ++ P    GP              PA  GPGG +G      GG
Sbjct: 140  GRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGG 199

Query: 1063 GQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSG 1122
             Q P    G     + SAA    P S + LQ+    Y  ++            GG GG G
Sbjct: 200  QQSP----GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGG 255

Query: 1123 GGGGGG 1128
            GGGGGG
Sbjct: 256  GGGGGG 261



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 69/249 (27%), Positives = 84/249 (33%), Gaps = 77/249 (30%)

Query: 951  HGPPSSHHHHHH----HHHHR--------------------------------------- 967
            H    +HHHHHH    HHHH                                        
Sbjct: 27   HHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAG 86

Query: 968  GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGP-----SGTDFTRR 1020
            GG P PG D   P HG +K +  + G   PP   +L      D+  P     +G  +   
Sbjct: 87   GGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHP 145

Query: 1021 QLSLQDNLQHMLSPPQITIGPQR------------PAPSGPGGGSGGGSGGGGGGQPPPL 1068
             L      Q  ++ P    GP              PA  GPGG +G      GG Q P  
Sbjct: 146  GLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-- 203

Query: 1069 QRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY---------GPARPRQQSLSKEGSIGGSG 1119
              G     + SAA    P S + LQ+    Y         G +RP        G  GG G
Sbjct: 204  --GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGG-GGGG 260

Query: 1120 GSGGGGGGG 1128
            GSGGGGGGG
Sbjct: 261  GSGGGGGGG 269



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 69/268 (25%), Positives = 92/268 (34%), Gaps = 28/268 (10%)

Query: 872  SSQASLTAALGLRPAPAGRLSQGS--GSSITAAGMR--------LSQMGVTTDGVPAQQL 921
            S+  SL  A G  P P   + Q    G+  +AAG +        LS+ G   D  P    
Sbjct: 77   SNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGE 136

Query: 922  RIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHG 981
                 +++P          P    GGGGG       ++++       G P G     F  
Sbjct: 137  PAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 982  YSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGP 1041
            +        G  + P   ++HS S +    P   D  +       N Q    P     G 
Sbjct: 197  H--------GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-----GY 243

Query: 1042 QRPAPSGPGGGSGGGSG--GGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
             RP   G GGG GGG G  GGGGG       G       +AA     ++G         Y
Sbjct: 244  SRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGG---GGGGGY 300

Query: 1100 GPARPRQQSLSKEGSIGGSGGSGGGGGG 1127
            G +      LS     GG    G GGGG
Sbjct: 301  GGSSAGYGVLSSPRQQGGGMMMGPGGGG 328



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 21/33 (63%), Positives = 22/33 (66%)

Query: 363 YPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKG 395
           YP     G+GG GG G GGGGGSGGG GG G G
Sbjct: 240 YPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 19/30 (63%), Positives = 19/30 (63%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G GG GG G GGG G GGG GG G GG  A
Sbjct: 249 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGA 278



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/36 (58%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 370 GSGGSGGMGSGGGGGSGG-GSGGKGKGGCPAVRLKA 404
           G GG GG GSGGGGG GG G+GG G G   A    A
Sbjct: 253 GGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAA 288



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 19/35 (54%), Positives = 19/35 (54%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKA 404
           G GG GG G G GGG GGG  G G  G  AV   A
Sbjct: 251 GGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAA 285



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 17/27 (62%), Positives = 18/27 (66%)

Query: 373 GSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G+GG G GGGGG GG  GG G GG  A
Sbjct: 247 GAGGGGGGGGGGGGGSGGGGGGGGAGA 273



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 83/347 (23%), Positives = 127/347 (36%), Gaps = 45/347 (12%)

Query: 786  LPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLD 845
            LPS ++++  P      +     S+PPLA   P +     ++ + E+     + S S+ D
Sbjct: 559  LPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNH--EDLNLIQQERPSSLPDLSGSIDD 616

Query: 846  LQGDGPGGRLNS--SSVSNLAAVGDLLHSSQASLTAAL---------GLRPAPAGR---L 891
            L   G    L+S  S+  + ++ GD  + +Q+  +            G  P+P G     
Sbjct: 617  LP-TGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGS 675

Query: 892  SQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFH----MAADGPGPPGGHGG 947
            +Q     I+ A +  SQM     G  ++    P   Q+P+      MA     P     G
Sbjct: 676  NQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYG 735

Query: 948  GGGHGPPSSHHHHHHHHHHRG-----GEPPGDTFAP-FHGYSKSEDLSSGVPKPPAASIL 1001
                GP  S H       H G           T+ P    Y    + S    +PPA S +
Sbjct: 736  PQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS----RPPAYSGV 791

Query: 1002 HSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPP---QITIGPQ-RPAPSG-----PGGG 1052
             S SYS   GP        Q+  Q   Q   + P     + G Q RP P       P   
Sbjct: 792  PSASYSGP-GPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSP 850

Query: 1053 SGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
                 GG G G P P    K+Q+   +  Q    ++ N  QS + S+
Sbjct: 851  GMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ----AAANSAQSRQGSF 893



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 56/240 (23%), Positives = 74/240 (30%), Gaps = 55/240 (22%)

Query: 939  PGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAA 998
            PG  GG GGGGG G  S            GG   G   A   G       ++      AA
Sbjct: 246  PGAGGGGGGGGGGGGGSG-----------GGGGGGGAGAGGAGAGAVAAAAA------AA 288

Query: 999  SILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGS----- 1053
            +          +G S   +             +LS P+   G     P G G  S     
Sbjct: 289  AAAAGGGGGGGYGGSSAGYG------------VLSSPRQQGGGMMMGPGGGGAASLSKAA 336

Query: 1054 -GGGSGG----GGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQS 1108
             G  +GG     G  Q P        QL  S +   R   G+  +   PS  P  P Q  
Sbjct: 337  AGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQ 396

Query: 1109 LSKEGSIGGSGGSGGGGGGGLKPSITKQH----------------SQTPSTLNPTMPASE 1152
                 +   +GG     G GL   +  Q+                + +P T  PTM  S+
Sbjct: 397  SQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQ 456



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 47/207 (22%), Positives = 65/207 (31%), Gaps = 45/207 (21%)

Query: 950  GHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDE 1009
            G  P +  H  HHHHHH          A  H +              A  + H H+   +
Sbjct: 15   GEAPAAPPHQQHHHHHH----------AHHHHHH-------------AHHLHHHHALQQQ 51

Query: 1010 FGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPG-GGSGGGSGGGGGGQPPPL 1068
                   F ++Q   Q   Q            Q P  +    GG+GGG+   G     P 
Sbjct: 52   L----NQFQQQQQQQQQQQQQQQQ-------QQHPISNNNSLGGAGGGAPQPGPDMEQPQ 100

Query: 1069 QRGKSQQLTVSAAQKPRP----SSGNLLQSPEPSYGPARPRQQSLSKEGSIGGS----GG 1120
              G         A  P P      G+   +P     PA  R +     G++G        
Sbjct: 101  HGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGL-GALGTQQPPVAV 159

Query: 1121 SGGGGGGGLKPSITKQH-SQTPSTLNP 1146
             GGGGG    P     + S  P++  P
Sbjct: 160  PGGGGGPAAVPEFNNYYGSAAPASGGP 186



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 16/38 (42%), Positives = 20/38 (52%)

Query: 359 TEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396
           + + YP +      G    G+GGGGG GGG GG   GG
Sbjct: 228 SHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGG 265



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 17/43 (39%), Positives = 18/43 (41%), Gaps = 17/43 (39%)

Query: 370 GSGGSGGMGSGG-----------------GGGSGGGSGGKGKG 395
           G GG GG G+GG                 GGG GGG GG   G
Sbjct: 264 GGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAG 306



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 17/44 (38%), Positives = 19/44 (43%), Gaps = 13/44 (29%)

Query: 369 TGSGGSGGMGSGGGGGSG-------------GGSGGKGKGGCPA 399
           +G GG GG    GG G+G             GG GG G GG  A
Sbjct: 262 SGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSA 305


>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 [Homo
            sapiens]
          Length = 2178

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 63/246 (25%), Positives = 78/246 (31%), Gaps = 75/246 (30%)

Query: 953  PPSSHHHHHHHHHHR--------------------------------------------- 967
            PP   HHHHHH HH                                              
Sbjct: 21   PPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNN 80

Query: 968  ------GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEF-----GPSG 1014
                  GG P PG D   P HG +K +  + G   PP   +L      D+       P+G
Sbjct: 81   SLGGAGGGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAG 139

Query: 1015 TDFTRRQLSLQDNLQHMLSPPQITIGP------------QRPAPSGPGGGSGGGSGGGGG 1062
              +    L      Q  ++ P    GP              PA  GPGG +G      GG
Sbjct: 140  GRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGG 199

Query: 1063 GQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSG 1122
             Q P    G     + SAA    P S + LQ+    Y  ++            GG GG G
Sbjct: 200  QQSP----GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGG 255

Query: 1123 GGGGGG 1128
            GGGGGG
Sbjct: 256  GGGGGG 261



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 69/249 (27%), Positives = 84/249 (33%), Gaps = 77/249 (30%)

Query: 951  HGPPSSHHHHHH----HHHHR--------------------------------------- 967
            H    +HHHHHH    HHHH                                        
Sbjct: 27   HHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAG 86

Query: 968  GGEP-PG-DTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDEFGP-----SGTDFTRR 1020
            GG P PG D   P HG +K +  + G   PP   +L      D+  P     +G  +   
Sbjct: 87   GGAPQPGPDMEQPQHGGAK-DSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHP 145

Query: 1021 QLSLQDNLQHMLSPPQITIGPQR------------PAPSGPGGGSGGGSGGGGGGQPPPL 1068
             L      Q  ++ P    GP              PA  GPGG +G      GG Q P  
Sbjct: 146  GLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSP-- 203

Query: 1069 QRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY---------GPARPRQQSLSKEGSIGGSG 1119
              G     + SAA    P S + LQ+    Y         G +RP        G  GG G
Sbjct: 204  --GMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGG-GGGG 260

Query: 1120 GSGGGGGGG 1128
            GSGGGGGGG
Sbjct: 261  GSGGGGGGG 269



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 69/268 (25%), Positives = 92/268 (34%), Gaps = 28/268 (10%)

Query: 872  SSQASLTAALGLRPAPAGRLSQGS--GSSITAAGMR--------LSQMGVTTDGVPAQQL 921
            S+  SL  A G  P P   + Q    G+  +AAG +        LS+ G   D  P    
Sbjct: 77   SNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGE 136

Query: 922  RIPLSFQNPLFHMAADGPGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHG 981
                 +++P          P    GGGGG       ++++       G P G     F  
Sbjct: 137  PAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQ 196

Query: 982  YSKSEDLSSGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGP 1041
            +        G  + P   ++HS S +    P   D  +       N Q    P     G 
Sbjct: 197  H--------GGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-----GY 243

Query: 1042 QRPAPSGPGGGSGGGSG--GGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
             RP   G GGG GGG G  GGGGG       G       +AA     ++G         Y
Sbjct: 244  SRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGG---GGGGGY 300

Query: 1100 GPARPRQQSLSKEGSIGGSGGSGGGGGG 1127
            G +      LS     GG    G GGGG
Sbjct: 301  GGSSAGYGVLSSPRQQGGGMMMGPGGGG 328



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 21/33 (63%), Positives = 22/33 (66%)

Query: 363 YPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKG 395
           YP     G+GG GG G GGGGGSGGG GG G G
Sbjct: 240 YPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAG 272



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 19/30 (63%), Positives = 19/30 (63%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G GG GG G GGG G GGG GG G GG  A
Sbjct: 249 GGGGGGGGGGGGGSGGGGGGGGAGAGGAGA 278



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 21/36 (58%), Positives = 22/36 (61%), Gaps = 1/36 (2%)

Query: 370 GSGGSGGMGSGGGGGSGG-GSGGKGKGGCPAVRLKA 404
           G GG GG GSGGGGG GG G+GG G G   A    A
Sbjct: 253 GGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAA 288



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 19/35 (54%), Positives = 19/35 (54%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKA 404
           G GG GG G G GGG GGG  G G  G  AV   A
Sbjct: 251 GGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAA 285



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 17/27 (62%), Positives = 18/27 (66%)

Query: 373 GSGGMGSGGGGGSGGGSGGKGKGGCPA 399
           G+GG G GGGGG GG  GG G GG  A
Sbjct: 247 GAGGGGGGGGGGGGGSGGGGGGGGAGA 273



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 83/347 (23%), Positives = 127/347 (36%), Gaps = 45/347 (12%)

Query: 786  LPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLD 845
            LPS ++++  P      +     S+PPLA   P +     ++ + E+     + S S+ D
Sbjct: 559  LPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNH--EDLNLIQQERPSSLPDLSGSIDD 616

Query: 846  LQGDGPGGRLNS--SSVSNLAAVGDLLHSSQASLTAAL---------GLRPAPAGR---L 891
            L   G    L+S  S+  + ++ GD  + +Q+  +            G  P+P G     
Sbjct: 617  LP-TGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGS 675

Query: 892  SQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFH----MAADGPGPPGGHGG 947
            +Q     I+ A +  SQM     G  ++    P   Q+P+      MA     P     G
Sbjct: 676  NQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYG 735

Query: 948  GGGHGPPSSHHHHHHHHHHRG-----GEPPGDTFAP-FHGYSKSEDLSSGVPKPPAASIL 1001
                GP  S H       H G           T+ P    Y    + S    +PPA S +
Sbjct: 736  PQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYS----RPPAYSGV 791

Query: 1002 HSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPP---QITIGPQ-RPAPSG-----PGGG 1052
             S SYS   GP        Q+  Q   Q   + P     + G Q RP P       P   
Sbjct: 792  PSASYSGP-GPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSP 850

Query: 1053 SGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
                 GG G G P P    K+Q+   +  Q    ++ N  QS + S+
Sbjct: 851  GMSQQGGPGMGPPMPTVNRKAQEAAAAVMQ----AAANSAQSRQGSF 893



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 56/240 (23%), Positives = 74/240 (30%), Gaps = 55/240 (22%)

Query: 939  PGPPGGHGGGGGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAA 998
            PG  GG GGGGG G  S            GG   G   A   G       ++      AA
Sbjct: 246  PGAGGGGGGGGGGGGGSG-----------GGGGGGGAGAGGAGAGAVAAAAA------AA 288

Query: 999  SILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGS----- 1053
            +          +G S   +             +LS P+   G     P G G  S     
Sbjct: 289  AAAAGGGGGGGYGGSSAGYG------------VLSSPRQQGGGMMMGPGGGGAASLSKAA 336

Query: 1054 -GGGSGG----GGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQS 1108
             G  +GG     G  Q P        QL  S +   R   G+  +   PS  P  P Q  
Sbjct: 337  AGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQ 396

Query: 1109 LSKEGSIGGSGGSGGGGGGGLKPSITKQH----------------SQTPSTLNPTMPASE 1152
                 +   +GG     G GL   +  Q+                + +P T  PTM  S+
Sbjct: 397  SQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQ 456



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 47/207 (22%), Positives = 65/207 (31%), Gaps = 45/207 (21%)

Query: 950  GHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKPPAASILHSHSYSDE 1009
            G  P +  H  HHHHHH          A  H +              A  + H H+   +
Sbjct: 15   GEAPAAPPHQQHHHHHH----------AHHHHHH-------------AHHLHHHHALQQQ 51

Query: 1010 FGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPG-GGSGGGSGGGGGGQPPPL 1068
                   F ++Q   Q   Q            Q P  +    GG+GGG+   G     P 
Sbjct: 52   L----NQFQQQQQQQQQQQQQQQQ-------QQHPISNNNSLGGAGGGAPQPGPDMEQPQ 100

Query: 1069 QRGKSQQLTVSAAQKPRP----SSGNLLQSPEPSYGPARPRQQSLSKEGSIGGS----GG 1120
              G         A  P P      G+   +P     PA  R +     G++G        
Sbjct: 101  HGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGL-GALGTQQPPVAV 159

Query: 1121 SGGGGGGGLKPSITKQH-SQTPSTLNP 1146
             GGGGG    P     + S  P++  P
Sbjct: 160  PGGGGGPAAVPEFNNYYGSAAPASGGP 186



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 16/38 (42%), Positives = 20/38 (52%)

Query: 359 TEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396
           + + YP +      G    G+GGGGG GGG GG   GG
Sbjct: 228 SHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGG 265



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 17/43 (39%), Positives = 18/43 (41%), Gaps = 17/43 (39%)

Query: 370 GSGGSGGMGSGG-----------------GGGSGGGSGGKGKG 395
           G GG GG G+GG                 GGG GGG GG   G
Sbjct: 264 GGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAG 306



 Score = 31.2 bits (69), Expect = 7.0
 Identities = 17/44 (38%), Positives = 19/44 (43%), Gaps = 13/44 (29%)

Query: 369 TGSGGSGGMGSGGGGGSG-------------GGSGGKGKGGCPA 399
           +G GG GG    GG G+G             GG GG G GG  A
Sbjct: 262 SGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSA 305


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 122/527 (23%), Positives = 175/527 (33%), Gaps = 85/527 (16%)

Query: 856  NSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDG 915
            +SSS S  A+      SS AS   A    P+        +  S++    + +Q  + +  
Sbjct: 377  SSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQA 436

Query: 916  VPAQQLRIPLSFQNPLFHMAAD-GPGPPGGHGGGGGHGPPSSHHHHH------------- 961
            V +Q    P  +   L +  A  GP PP        H P S+HHHHH             
Sbjct: 437  VWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQ 496

Query: 962  -----HHHHHRGGEPPGDTFAPF--------HGYSKSEDLSSGVPKPPAASIL---HSHS 1005
                  HH + G  PPG    P         H Y+ S  L S  P PP  + L   HS  
Sbjct: 497  QQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556

Query: 1006 YSDEFGPSGTDFTRRQLSLQDNLQ--HMLSPPQITIGPQ-RPAPSGP------------- 1049
               + GP+G   +    S     Q  +  S P  + GPQ  P P  P             
Sbjct: 557  SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLST 616

Query: 1050 ----GGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPR 1105
                   S  G        PPP               K  PS G    +  P Y P  P 
Sbjct: 617  VIATVASSPAGYKTASPPGPPPY-------------GKRAPSPGAYKTATPPGYKPGSP- 662

Query: 1106 QQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLS 1165
              S       G  G S   G G  KP      +  P  L P  P+   ++      P   
Sbjct: 663  -PSFRTGTPPGYRGTSPPAGPGTFKPG---SPTVGPGPLPPAGPSGLPSLPPPPAAPASG 718

Query: 1166 ADIESAHIER---EEYKLKEYSKSMDESRLDRVKEYEEEIH---SLKERLHMSNRKLEEY 1219
              + +  I++   EEY+  E       S     K  +   H   S +   H+ +R     
Sbjct: 719  PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHL-DRGFNSC 777

Query: 1220 ERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPA 1279
             R  L         L + +A L +  +R  +Q+A ++ +           E E  R+   
Sbjct: 778  ARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKE----------REREREREKER 827

Query: 1280 MAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPP 1326
              E   E ++ +  AQE + P   P+   V   PP+   +  A  PP
Sbjct: 828  EREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPP 874



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 43/153 (28%), Positives = 55/153 (35%), Gaps = 28/153 (18%)

Query: 1046 PSGP-GGGSGGGSGGGGGGQ--PPPLQRGKSQQLTVSAAQKPRP-----SSGNLLQSPEP 1097
            P GP GGG+    GG  GG+  PPP           S A   +P       GNL  +P P
Sbjct: 232  PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPP 291

Query: 1098 SYGP-----------ARPRQQSLSKEGSIGGSGGSG--------GGGGGGLKPSITKQHS 1138
            +  P            RP   + +    +G     G        G G GGL P   K  +
Sbjct: 292  ANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPT 351

Query: 1139 QTPSTLNPTMPASERTVAWVSNMPHLSADIESA 1171
              PS  +   PAS    A     P+ S+   SA
Sbjct: 352  LAPSP-HSLPPASSSAPAPPMRFPYSSSSSSSA 383


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 122/527 (23%), Positives = 175/527 (33%), Gaps = 85/527 (16%)

Query: 856  NSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDG 915
            +SSS S  A+      SS AS   A    P+        +  S++    + +Q  + +  
Sbjct: 377  SSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPKYTQPSLPSQA 436

Query: 916  VPAQQLRIPLSFQNPLFHMAAD-GPGPPGGHGGGGGHGPPSSHHHHH------------- 961
            V +Q    P  +   L +  A  GP PP        H P S+HHHHH             
Sbjct: 437  VWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQ 496

Query: 962  -----HHHHHRGGEPPGDTFAPF--------HGYSKSEDLSSGVPKPPAASIL---HSHS 1005
                  HH + G  PPG    P         H Y+ S  L S  P PP  + L   HS  
Sbjct: 497  QQQQQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQV 556

Query: 1006 YSDEFGPSGTDFTRRQLSLQDNLQ--HMLSPPQITIGPQ-RPAPSGP------------- 1049
               + GP+G   +    S     Q  +  S P  + GPQ  P P  P             
Sbjct: 557  SYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPSQGPQGAPYPFPPVPTVTTSSATLST 616

Query: 1050 ----GGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPR 1105
                   S  G        PPP               K  PS G    +  P Y P  P 
Sbjct: 617  VIATVASSPAGYKTASPPGPPPY-------------GKRAPSPGAYKTATPPGYKPGSP- 662

Query: 1106 QQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLS 1165
              S       G  G S   G G  KP      +  P  L P  P+   ++      P   
Sbjct: 663  -PSFRTGTPPGYRGTSPPAGPGTFKPG---SPTVGPGPLPPAGPSGLPSLPPPPAAPASG 718

Query: 1166 ADIESAHIER---EEYKLKEYSKSMDESRLDRVKEYEEEIH---SLKERLHMSNRKLEEY 1219
              + +  I++   EEY+  E       S     K  +   H   S +   H+ +R     
Sbjct: 719  PPLSATQIKQEPAEEYETPESPVPPARSPSPPPKVVDVPSHASQSARFNKHL-DRGFNSC 777

Query: 1220 ERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPA 1279
             R  L         L + +A L +  +R  +Q+A ++ +           E E  R+   
Sbjct: 778  ARSDLYFVPLEGSKLAKKRADLVEKVRREAEQRAREEKE----------REREREREKER 827

Query: 1280 MAEPLPEPKKRLLDAQERQLPPLGPTNPRVTLAPPWNGLAPPAPPPP 1326
              E   E ++ +  AQE + P   P+   V   PP+   +  A  PP
Sbjct: 828  EREKERELERSVKLAQEGRAPVECPSLGPVPHRPPFEPGSAVATVPP 874



 Score = 38.5 bits (88), Expect = 0.044
 Identities = 43/153 (28%), Positives = 55/153 (35%), Gaps = 28/153 (18%)

Query: 1046 PSGP-GGGSGGGSGGGGGGQ--PPPLQRGKSQQLTVSAAQKPRP-----SSGNLLQSPEP 1097
            P GP GGG+    GG  GG+  PPP           S A   +P       GNL  +P P
Sbjct: 232  PMGPKGGGAASSVGGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPP 291

Query: 1098 SYGP-----------ARPRQQSLSKEGSIGGSGGSG--------GGGGGGLKPSITKQHS 1138
            +  P            RP   + +    +G     G        G G GGL P   K  +
Sbjct: 292  ANFPHVTPNLPPPPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPT 351

Query: 1139 QTPSTLNPTMPASERTVAWVSNMPHLSADIESA 1171
              PS  +   PAS    A     P+ S+   SA
Sbjct: 352  LAPSP-HSLPPASSSAPAPPMRFPYSSSSSSSA 383


>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
            [Homo sapiens]
          Length = 526

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 60/193 (31%), Positives = 74/193 (38%), Gaps = 31/193 (16%)

Query: 942  PGGHGGGGGHGPP-SSHHHHHHHHHHRG-GEPPGDTFAPFHGYSKSEDLSSGVPKPPAAS 999
            P G+G  GG+G   SS   +     + G G+ P  +       S S+  S G P+     
Sbjct: 72   PQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQ----- 126

Query: 1000 ILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGG 1059
               S SYS +    G   +  Q       Q   +PPQ   G Q    S  GGG GGG GG
Sbjct: 127  ---SGSYSQQPSYGGQQQSYGQ-------QQSYNPPQ-GYGQQNQYNSSSGGGGGGGGGG 175

Query: 1060 GGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSG 1119
              G            Q ++S+        GN  Q      G     QQ     G  GGSG
Sbjct: 176  NYG----------QDQSSMSSGGGSGGGYGN--QDQSGGGGSGGYGQQDRGGRGR-GGSG 222

Query: 1120 GSGGGGGGGLKPS 1132
            G GGGGGGG   S
Sbjct: 223  GGGGGGGGGYNRS 235



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 4/89 (4%)

Query: 1040 GPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSY 1099
            G  R  P G GG  GGGSGGGG G  P    G   Q      + P P+  N+      S+
Sbjct: 385  GRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENM----NFSW 440

Query: 1100 GPARPRQQSLSKEGSIGGSGGSGGGGGGG 1128
                 + ++   +G  GG GGS  GG  G
Sbjct: 441  RNECNQCKAPKPDGPGGGPGGSHMGGNYG 469



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 18/92 (19%)

Query: 325 LHLYRDSDKKRKKDKAGYVGLVTVPVATLA-----GRHFTEQWYPVTLPT--------GS 371
           ++LY D +  + K +A  V     P A  A     G+ F+     V+  T        G 
Sbjct: 322 INLYTDRETGKLKGEAT-VSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGG 380

Query: 372 GGSGGMGSGG----GGGSGGGSGGKGKGGCPA 399
            G GG G GG    GG  GGGSGG G+GG P+
Sbjct: 381 NGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPS 412



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 19/29 (65%), Positives = 19/29 (65%)

Query: 368 PTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396
           P G GG GG GSGGGG  G  SGG G GG
Sbjct: 391 PMGRGGYGGGGSGGGGRGGFPSGGGGGGG 419



 Score = 37.7 bits (86), Expect = 0.075
 Identities = 18/30 (60%), Positives = 20/30 (66%), Gaps = 3/30 (10%)

Query: 370 GSGGSGGMGSGGGGGSGGGSGG---KGKGG 396
           G GGSGG G GGGGG    SGG   +G+GG
Sbjct: 217 GRGGSGGGGGGGGGGYNRSSGGYEPRGRGG 246



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 18/29 (62%), Positives = 19/29 (65%), Gaps = 1/29 (3%)

Query: 369 TGSGGSGGMGSGGGGGSG-GGSGGKGKGG 396
           +G GGSGG G    GG G GGSGG G GG
Sbjct: 200 SGGGGSGGYGQQDRGGRGRGGSGGGGGGG 228



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 18/32 (56%), Positives = 18/32 (56%), Gaps = 3/32 (9%)

Query: 370 GSGGSGGMGSGG---GGGSGGGSGGKGKGGCP 398
           G GGSGG G GG   GGG GGG    G   CP
Sbjct: 398 GGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCP 429



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 15/25 (60%), Positives = 16/25 (64%)

Query: 372 GGSGGMGSGGGGGSGGGSGGKGKGG 396
           GG G  GSGGGGG GGG   +  GG
Sbjct: 214 GGRGRGGSGGGGGGGGGGYNRSSGG 238



 Score = 34.3 bits (77), Expect = 0.83
 Identities = 21/45 (46%), Positives = 22/45 (48%), Gaps = 17/45 (37%)

Query: 369 TGSGGSGGMGSGG-----------GGGSGGG------SGGKGKGG 396
           + SGG GG G GG           GGGSGGG      SGG G GG
Sbjct: 163 SSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGG 207



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 17/38 (44%), Positives = 23/38 (60%), Gaps = 7/38 (18%)

Query: 366 TLPTGSGGSGGMGS---GGGGGSGG----GSGGKGKGG 396
           ++ +G G  GG G+    GGGGSGG      GG+G+GG
Sbjct: 183 SMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGG 220


>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
            sapiens]
          Length = 2506

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 61/222 (27%), Positives = 84/222 (37%), Gaps = 58/222 (26%)

Query: 958  HHHHHHHHHRGGEPPGDTFA---PFHGYSKSEDL------------------SSGVPKPP 996
            HHHHHHHHH    P  D +A   P HG +++ D                   SS V   P
Sbjct: 2210 HHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSP 2269

Query: 997  AASILHSH--------------------SYSD---EFGPSGTDFTRRQLSLQDNLQHMLS 1033
            A S   +                     SYS    + G SG    ++Q   Q   Q +  
Sbjct: 2270 APSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVAR 2329

Query: 1034 PPQ-ITIGPQR-PAPSG-PGGGSGGGSGGGGGGQPPPLQR---GKSQQLTVSAAQKPR-- 1085
            P +  T GP+R P P+  P  G    +GG   G+ P ++R   G ++  +  A +     
Sbjct: 2330 PGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGAR 2389

Query: 1086 -PSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGG 1126
             P+SG     P  S GP  PR     +      + G G GGG
Sbjct: 2390 WPASG-----PHVSEGPPGPRHHGYYRGSDYDEADGPGSGGG 2426



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 47/187 (25%), Positives = 65/187 (34%), Gaps = 37/187 (19%)

Query: 949  GGHGPPSSHHHHHHHHHHRGGEPPGD--TFAPFHGYSKSEDLSSGVPKPPAASILHSHSY 1006
            GG GPP            +    PG   T  P      + +  +G  +PP     HS   
Sbjct: 2307 GGSGPPQQQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLAG-DRPPTGG--HSSGR 2363

Query: 1007 SDEF-----GPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPA------------PSGP 1049
            S        GP+ ++  R         +   S P ++ GP  P               GP
Sbjct: 2364 SPRMERRVPGPARSESPRA--CRHGGARWPASGPHVSEGPPGPRHHGYYRGSDYDEADGP 2421

Query: 1050 GGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPE-----------PS 1098
            G G G  +  G    PPP+ R  S   T  + + PR +SG    SP            P+
Sbjct: 2422 GSGGGEEAMAGAYDAPPPV-RHASSGATGRSPRTPR-ASGPACASPSRHGRRLPNGYYPA 2479

Query: 1099 YGPARPR 1105
            +G ARPR
Sbjct: 2480 HGLARPR 2486



 Score = 31.6 bits (70), Expect = 5.4
 Identities = 29/88 (32%), Positives = 35/88 (39%), Gaps = 26/88 (29%)

Query: 1040 GPQRPAPSGPGG---------GSGGGSGGGG---GGQPPPLQRGKSQQLTVSAAQKPRPS 1087
            G + PA  G GG         GSGGG G GG   GGQP     G  +    S AQ+ R  
Sbjct: 5    GDEMPARYGGGGSGAAAGVVVGSGGGRGAGGSRQGGQP-----GAQRMYKQSMAQRARTM 59

Query: 1088 SGNLLQSPEPSYGPARPRQQSLSKEGSI 1115
            +          Y P   RQ  L+   S+
Sbjct: 60   A---------LYNPIPVRQNCLTVNRSL 78


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,051,871
Number of Sequences: 37866
Number of extensions: 3775018
Number of successful extensions: 77723
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 656
Number of HSP's successfully gapped in prelim test: 1252
Number of HSP's that attempted gapping in prelim test: 34750
Number of HSP's gapped (non-prelim): 29564
length of query: 1343
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1229
effective length of database: 13,930,794
effective search space: 17120945826
effective search space used: 17120945826
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.