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Search of human proteins with 193211600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
(455 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens] 937 0.0
gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens] 788 0.0
gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens] 657 0.0
gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens] 599 e-171
gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens] 596 e-170
gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens] 595 e-170
gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens] 517 e-147
gi|122937199 protein phosphatase 1B-like [Homo sapiens] 296 3e-80
gi|29558099 protein phosphatase 1B isoform 3 [Homo sapiens] 135 8e-32
gi|4505999 protein phosphatase 1G [Homo sapiens] 130 2e-30
gi|29826282 protein phosphatase 1G [Homo sapiens] 130 2e-30
gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens] 124 2e-28
gi|13540531 integrin-linked kinase-associated protein phosphatas... 120 2e-27
gi|167466276 protein phosphatase 1K (PP2C domain containing) [Ho... 111 1e-24
gi|7661862 protein phosphatase 1F [Homo sapiens] 96 5e-20
gi|30089948 protein phosphatase 1E [Homo sapiens] 94 3e-19
gi|4505997 protein phosphatase 1D [Homo sapiens] 87 3e-17
gi|149944715 protein phosphatase 1H (PP2C domain containing) [Ho... 50 4e-06
gi|171460934 protein phosphatase 1M isoform b [Homo sapiens] 49 7e-06
gi|171460932 protein phosphatase 1M isoform a [Homo sapiens] 49 7e-06
gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo... 48 2e-05
gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit ... 44 3e-04
gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit... 44 3e-04
gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit... 44 3e-04
gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit... 44 3e-04
gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit... 44 3e-04
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 44 4e-04
gi|65506328 protein phosphatase 1J (PP2C domain containing) [Hom... 42 0.001
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens] 42 0.002
gi|5174703 mitogen-activated protein kinase kinase kinase 7 inte... 42 0.002
>gi|193211600 protein phosphatase 1A isoform 3 [Homo sapiens]
Length = 455
Score = 937 bits (2421), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MFCSGRKWVAEATICTKLMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCE 60
MFCSGRKWVAEATICTKLMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCE
Sbjct: 1 MFCSGRKWVAEATICTKLMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCE 60
Query: 61 RKKYETDLEDQDIMGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLP 120
RKKYETDLEDQDIMGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLP
Sbjct: 61 RKKYETDLEDQDIMGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLP 120
Query: 121 SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLE 180
SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLE
Sbjct: 121 SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLE 180
Query: 181 IDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPS 240
IDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPS
Sbjct: 181 IDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPS 240
Query: 241 NPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERS 300
NPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERS
Sbjct: 241 NPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERS 300
Query: 301 EEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVI 360
EEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVI
Sbjct: 301 EEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVI 360
Query: 361 LICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPP 420
LICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPP
Sbjct: 361 LICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPP 420
Query: 421 GGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW 455
GGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW
Sbjct: 421 GGELASKRNVIEAVYNRLNPYKNDDTDSTSTDDMW 455
>gi|10337595 protein phosphatase 1A isoform 1 [Homo sapiens]
Length = 382
Score = 788 bits (2035), Expect = 0.0
Identities = 382/382 (100%), Positives = 382/382 (100%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD
Sbjct: 1 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH 193
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
Sbjct: 61 GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH 120
Query: 194 GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG 253
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG
Sbjct: 121 GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG 180
Query: 254 SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG 313
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
Sbjct: 181 SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG 240
Query: 314 IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 373
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
Sbjct: 241 IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 300
Query: 374 AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA 433
AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA
Sbjct: 301 AVKKEAELDKYLECRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA 360
Query: 434 VYNRLNPYKNDDTDSTSTDDMW 455
VYNRLNPYKNDDTDSTSTDDMW
Sbjct: 361 VYNRLNPYKNDDTDSTSTDDMW 382
>gi|29557855 protein phosphatase 1A isoform 2 [Homo sapiens]
Length = 324
Score = 657 bits (1694), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD
Sbjct: 1 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH 193
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
Sbjct: 61 GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH 120
Query: 194 GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG 253
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG
Sbjct: 121 GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG 180
Query: 254 SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG 313
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
Sbjct: 181 SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG 240
Query: 314 IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 373
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
Sbjct: 241 IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 300
Query: 374 AVKKEAELDKYLECRVE 390
AVKKEAELDKYLECRVE
Sbjct: 301 AVKKEAELDKYLECRVE 317
>gi|29558022 protein phosphatase 1B isoform 2 [Homo sapiens]
Length = 387
Score = 599 bits (1545), Expect = e-171
Identities = 294/388 (75%), Positives = 336/388 (86%), Gaps = 7/388 (1%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPK EKHNA G GNGLRYGLSSMQGWRVEMEDAHTAV+G+P GLE WSFFAVYD
Sbjct: 1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFK-----GSAGAPSVENVKNGIRTGFLEIDEHMRVM 188
GHAGS+VA YC HLL+HIT N+DF+ GSA SVENVKNGIRTGFL+IDE+MR
Sbjct: 61 GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF 120
Query: 189 SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERI 248
S+ ++G DRSGSTAVGV+ISP+H YFINCGDSR +L RN +V F TQDHKP NP EKERI
Sbjct: 121 SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI 180
Query: 249 QNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFII 308
QNAGGSVMIQRVNGSLAVSRALGD+DYKCV GKGPTEQLVSPEPEV++I R+EE D+FII
Sbjct: 181 QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEE-DEFII 239
Query: 309 LACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAP 368
LACDGIWDVM NEELC++V+SRLEV+DDLE VCN VVDTCL+KGSRDNMS++L+CF NAP
Sbjct: 240 LACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAP 299
Query: 369 KVSPEAVKKEAELDKYLECRVEEIIKKQG-EGVPDLVHVMRTLASENIPSLPPGGELASK 427
KVS EAVKK++ELDK+LE RVEEI++K G EG+PDL HVMR L++ENIP+LPPGG LA K
Sbjct: 300 KVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGK 359
Query: 428 RNVIEAVYNRLNPYKNDDTDSTSTDDMW 455
RNVIEAVY+RLNP++ D + +D W
Sbjct: 360 RNVIEAVYSRLNPHRESDGGAGDLEDPW 387
>gi|4505995 protein phosphatase 1B isoform 1 [Homo sapiens]
Length = 479
Score = 596 bits (1536), Expect = e-170
Identities = 293/386 (75%), Positives = 335/386 (86%), Gaps = 7/386 (1%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPK EKHNA G GNGLRYGLSSMQGWRVEMEDAHTAV+G+P GLE WSFFAVYD
Sbjct: 1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFK-----GSAGAPSVENVKNGIRTGFLEIDEHMRVM 188
GHAGS+VA YC HLL+HIT N+DF+ GSA SVENVKNGIRTGFL+IDE+MR
Sbjct: 61 GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF 120
Query: 189 SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERI 248
S+ ++G DRSGSTAVGV+ISP+H YFINCGDSR +L RN +V F TQDHKP NP EKERI
Sbjct: 121 SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI 180
Query: 249 QNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFII 308
QNAGGSVMIQRVNGSLAVSRALGD+DYKCV GKGPTEQLVSPEPEV++I R+EE D+FII
Sbjct: 181 QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEE-DEFII 239
Query: 309 LACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAP 368
LACDGIWDVM NEELC++V+SRLEV+DDLE VCN VVDTCL+KGSRDNMS++L+CF NAP
Sbjct: 240 LACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAP 299
Query: 369 KVSPEAVKKEAELDKYLECRVEEIIKKQG-EGVPDLVHVMRTLASENIPSLPPGGELASK 427
KVS EAVKK++ELDK+LE RVEEI++K G EG+PDL HVMR L++ENIP+LPPGG LA K
Sbjct: 300 KVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGK 359
Query: 428 RNVIEAVYNRLNPYKNDDTDSTSTDD 453
RNVIEAVY+RLNP++ D S ++
Sbjct: 360 RNVIEAVYSRLNPHRESDGASDEAEE 385
>gi|75813620 protein phosphatase 1B isoform 5 [Homo sapiens]
Length = 380
Score = 595 bits (1533), Expect = e-170
Identities = 292/378 (77%), Positives = 332/378 (87%), Gaps = 7/378 (1%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPK EKHNA G GNGLRYGLSSMQGWRVEMEDAHTAV+G+P GLE WSFFAVYD
Sbjct: 1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFK-----GSAGAPSVENVKNGIRTGFLEIDEHMRVM 188
GHAGS+VA YC HLL+HIT N+DF+ GSA SVENVKNGIRTGFL+IDE+MR
Sbjct: 61 GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF 120
Query: 189 SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERI 248
S+ ++G DRSGSTAVGV+ISP+H YFINCGDSR +L RN +V F TQDHKP NP EKERI
Sbjct: 121 SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI 180
Query: 249 QNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFII 308
QNAGGSVMIQRVNGSLAVSRALGD+DYKCV GKGPTEQLVSPEPEV++I R+EE D+FII
Sbjct: 181 QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEE-DEFII 239
Query: 309 LACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAP 368
LACDGIWDVM NEELC++V+SRLEV+DDLE VCN VVDTCL+KGSRDNMS++L+CF NAP
Sbjct: 240 LACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAP 299
Query: 369 KVSPEAVKKEAELDKYLECRVEEIIKKQG-EGVPDLVHVMRTLASENIPSLPPGGELASK 427
KVS EAVKK++ELDK+LE RVEEI++K G EG+PDL HVMR L++ENIP+LPPGG LA K
Sbjct: 300 KVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENIPNLPPGGGLAGK 359
Query: 428 RNVIEAVYNRLNPYKNDD 445
RNVIEAVY+RLNP++ D
Sbjct: 360 RNVIEAVYSRLNPHRESD 377
>gi|75813618 protein phosphatase 1B isoform 4 [Homo sapiens]
Length = 327
Score = 517 bits (1331), Expect = e-147
Identities = 253/322 (78%), Positives = 284/322 (88%), Gaps = 6/322 (1%)
Query: 74 MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYD 133
MGAFLDKPK EKHNA G GNGLRYGLSSMQGWRVEMEDAHTAV+G+P GLE WSFFAVYD
Sbjct: 1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYD 60
Query: 134 GHAGSQVAKYCCEHLLDHITNNQDFK-----GSAGAPSVENVKNGIRTGFLEIDEHMRVM 188
GHAGS+VA YC HLL+HIT N+DF+ GSA SVENVKNGIRTGFL+IDE+MR
Sbjct: 61 GHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNF 120
Query: 189 SEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERI 248
S+ ++G DRSGSTAVGV+ISP+H YFINCGDSR +L RN +V F TQDHKP NP EKERI
Sbjct: 121 SDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERI 180
Query: 249 QNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFII 308
QNAGGSVMIQRVNGSLAVSRALGD+DYKCV GKGPTEQLVSPEPEV++I R+EE D+FII
Sbjct: 181 QNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEE-DEFII 239
Query: 309 LACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAP 368
LACDGIWDVM NEELC++V+SRLEV+DDLE VCN VVDTCL+KGSRDNMS++L+CF NAP
Sbjct: 240 LACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAP 299
Query: 369 KVSPEAVKKEAELDKYLECRVE 390
KVS EAVKK++ELDK+LE RVE
Sbjct: 300 KVSDEAVKKDSELDKHLESRVE 321
>gi|122937199 protein phosphatase 1B-like [Homo sapiens]
Length = 430
Score = 296 bits (758), Expect = 3e-80
Identities = 171/406 (42%), Positives = 232/406 (57%), Gaps = 26/406 (6%)
Query: 35 KREEKKKGGERRRNEKRGNQMKRMCERKKYETDLEDQDIMGAFLDKPKMEK--HNAQGQG 92
K+E +K+G E E+ G +R E + + L P+ + H
Sbjct: 18 KKEREKEGREEEEEEEAG---RRAPEGPR------------SLLTAPRRAQRPHGGAEAS 62
Query: 93 NGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHI 152
GLR+G S+ QGWR MEDAH + LP W+ FAV DGH G++ A++ HL H+
Sbjct: 63 GGLRFGASAAQGWRARMEDAHCTWLSLPGLPPGWALFAVLDGHGGARAARFGARHLPGHV 122
Query: 153 TNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHT 212
Q+ P E V+ +R FL DE +R + + + G TAV +L+SP+
Sbjct: 123 L--QELGPEPSEP--EGVREALRRAFLSADERLRSLWPR---VETGGCTAVVLLVSPRFL 175
Query: 213 YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGD 272
Y +CGDSR +L R V F T+DH+P P E+ERI AGG++ +RV GSLAVSRALGD
Sbjct: 176 YLAHCGDSRAVLSRAGAVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAVSRALGD 235
Query: 273 FDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLE 332
F YK G+ P QLVS EPEV + R E D+F++LA DG+WD + L V SRL
Sbjct: 236 FTYKEAPGRPPELQLVSAEPEVAALARQAE-DEFMLLASDGVWDTVSGAALAGLVASRLR 294
Query: 333 VTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEI 392
+ E +C +++DTCL KGS DNM+ IL+CFP AP+ S EA+++E LD L CR+ E+
Sbjct: 295 LGLAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAALGCRIAEL 354
Query: 393 IKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRL 438
+ P L V RTLASE+IP LPPGG L K VI VY+++
Sbjct: 355 C-ASAQKPPSLNTVFRTLASEDIPDLPPGGGLDCKATVIAEVYSQI 399
>gi|29558099 protein phosphatase 1B isoform 3 [Homo sapiens]
Length = 192
Score = 135 bits (340), Expect = 8e-32
Identities = 65/98 (66%), Positives = 82/98 (83%), Gaps = 1/98 (1%)
Query: 357 MSVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKKQGE-GVPDLVHVMRTLASENI 415
MS++L+CF NAPKVS EAVKK++ELDK+LE RVEEI++K GE G+PDL HVMR L++ENI
Sbjct: 1 MSIVLVCFSNAPKVSDEAVKKDSELDKHLESRVEEIMEKSGEEGMPDLAHVMRILSAENI 60
Query: 416 PSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSTSTDD 453
P+LPPGG LA KRNVIEAVY+RLNP++ D S ++
Sbjct: 61 PNLPPGGGLAGKRNVIEAVYSRLNPHRESDGASDEAEE 98
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 130 bits (328), Expect = 2e-30
Identities = 81/218 (37%), Positives = 124/218 (56%), Gaps = 18/218 (8%)
Query: 180 EIDEHMRV--MSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDH 237
E +E M V M K+ SG+TAV LI + N GDSR ++ K + DH
Sbjct: 307 EEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDH 366
Query: 238 KPSNPLEKERIQNAGGSV-MIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHD 296
KP + +E RI+NAGG V M RVNG L +SRA+GD YK P EQ++S P++
Sbjct: 367 KPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKV 426
Query: 297 IERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDD------LEKVCNEVVDTCLY 350
+ + +D +F+++ACDGIW+VM ++E+ DF++S++ D+ L + E++D CL
Sbjct: 427 LTLT-DDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLA 485
Query: 351 KGSR------DNMSVILICFP--NAPKVSPEAVKKEAE 380
+ DNM+ I+ICF N ++ PE+ K++ E
Sbjct: 486 PDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLE 523
Score = 75.9 bits (185), Expect = 7e-14
Identities = 47/129 (36%), Positives = 65/129 (50%), Gaps = 13/129 (10%)
Query: 74 MGAFLDKPKMEKHNAQGQGNG---LRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFA 130
MGA+L +P K + G G L YG S+MQGWRV MEDAH + L S + F+
Sbjct: 1 MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDS---ETAMFS 57
Query: 131 VYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSE 190
VYDGH G +VA YC ++L D I + + +K ++ + FL ID +
Sbjct: 58 VYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-------KLQKALEDAFLAIDAKLTTEEV 110
Query: 191 KKHGADRSG 199
K A +G
Sbjct: 111 IKELAQIAG 119
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 130 bits (328), Expect = 2e-30
Identities = 81/218 (37%), Positives = 124/218 (56%), Gaps = 18/218 (8%)
Query: 180 EIDEHMRV--MSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDH 237
E +E M V M K+ SG+TAV LI + N GDSR ++ K + DH
Sbjct: 307 EEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDH 366
Query: 238 KPSNPLEKERIQNAGGSV-MIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHD 296
KP + +E RI+NAGG V M RVNG L +SRA+GD YK P EQ++S P++
Sbjct: 367 KPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKV 426
Query: 297 IERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDD------LEKVCNEVVDTCLY 350
+ + +D +F+++ACDGIW+VM ++E+ DF++S++ D+ L + E++D CL
Sbjct: 427 LTLT-DDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLA 485
Query: 351 KGSR------DNMSVILICFP--NAPKVSPEAVKKEAE 380
+ DNM+ I+ICF N ++ PE+ K++ E
Sbjct: 486 PDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLE 523
Score = 75.9 bits (185), Expect = 7e-14
Identities = 47/129 (36%), Positives = 65/129 (50%), Gaps = 13/129 (10%)
Query: 74 MGAFLDKPKMEKHNAQGQGNG---LRYGLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFA 130
MGA+L +P K + G G L YG S+MQGWRV MEDAH + L S + F+
Sbjct: 1 MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDS---ETAMFS 57
Query: 131 VYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSE 190
VYDGH G +VA YC ++L D I + + +K ++ + FL ID +
Sbjct: 58 VYDGHGGEEVALYCAKYLPDIIKDQKAYKEG-------KLQKALEDAFLAIDAKLTTEEV 110
Query: 191 KKHGADRSG 199
K A +G
Sbjct: 111 IKELAQIAG 119
>gi|63003905 protein phosphatase 1 (formerly 2C)-like [Homo sapiens]
Length = 360
Score = 124 bits (311), Expect = 2e-28
Identities = 86/278 (30%), Positives = 141/278 (50%), Gaps = 19/278 (6%)
Query: 101 SMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNN-QDFK 159
S+QG R MED + L + S F ++DGH G A+Y L + + + QD++
Sbjct: 97 SIQGRRDHMEDRFEVLTDLANKTHP-SIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYE 155
Query: 160 GSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGD 219
SV + + + L ID M + + D +G+T + L+S + N GD
Sbjct: 156 KDK-ENSVLSYQTILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLTVANVGD 212
Query: 220 SRGLLC-RNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRALGDFDY 275
SRG+LC ++ + DHKP E++RI+ AGG + RV G LA+SR+LGD+
Sbjct: 213 SRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPL 272
Query: 276 KCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD 335
K ++ +V P+P++ + + +F+ILA DG+WD NEE F++ RL D
Sbjct: 273 KNLN-------VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERL---D 322
Query: 336 DLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE 373
+ +V Y+G DN++V+++ F N+ K +
Sbjct: 323 EPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEQ 360
>gi|13540531 integrin-linked kinase-associated protein phosphatase
2C [Homo sapiens]
Length = 392
Score = 120 bits (302), Expect = 2e-27
Identities = 99/298 (33%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 94 GLRYGLSSMQGWRVEMEDAHTAVIGL------PSGLESW-SFFAVYDGHAGSQVAKYCCE 146
GL+ ++ +G R EM+DAH + + PS L + S+FAV+DGH G + +K+ +
Sbjct: 106 GLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQ 165
Query: 147 HLLDHITNNQDFKGSAGAPSVEN-VKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGV 205
+L ++ KG SVE VK + F DE + + A + GSTA V
Sbjct: 166 NLHQNLIRKFP-KGDV--ISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCV 222
Query: 206 LISPQHTYFINCGDSRGLLCRNRKVH------FFTQDHKPSNPLEKERIQNAGGSVMIQR 259
L Y N GDSR +LCR + +++H P+ E+ RIQ AGG+V R
Sbjct: 223 LAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGR 282
Query: 260 VNGSLAVSRALGDFDYK-CVHGKGPTEQLVSPEPEVHDIERSE--EDDQFIILACDGIWD 316
V G L VSR++GD YK C G T V DI R + +D+FI+LACDG++
Sbjct: 283 VLGVLEVSRSIGDGQYKRC----GVT--------SVPDIRRCQLTPNDRFILLACDGLFK 330
Query: 317 VMGNEELCDFVRSRLE------------VTDDLEKVCNEVVDTCLYKGSRDNMSVILI 362
V EE +F+ S LE E CN + + + +GS DN++V+++
Sbjct: 331 VFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVV 388
>gi|167466276 protein phosphatase 1K (PP2C domain containing) [Homo
sapiens]
Length = 372
Score = 111 bits (278), Expect = 1e-24
Identities = 88/277 (31%), Positives = 130/277 (46%), Gaps = 36/277 (12%)
Query: 98 GLSSMQGWRVEMEDAHTAVIGLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQD 157
G +S G R E ED + +FAVYDGH G A +C H+ I +
Sbjct: 96 GCASQIGKRKENEDR----FDFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDL-- 149
Query: 158 FKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADR----SGSTA-VGVLISPQHT 212
P +N++ + FLEID+ S + AD SG+TA V +L
Sbjct: 150 ------LPKEKNLETLLTLAFLEIDKAFS--SHARLSADATLLTSGTTATVALLRDGIEL 201
Query: 213 YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGG-----SVMIQRVNGSLAVS 267
+ GDSR +LCR K T DH P EKERI+ GG S+ VNG LA++
Sbjct: 202 VVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMT 261
Query: 268 RALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
R++GD D K T +++ EPE I+ DD F++L DGI ++ ++E+CDFV
Sbjct: 262 RSIGDLDLK-------TSGVIA-EPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFV 313
Query: 328 RSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICF 364
D + + V + + G+ DN + +++ F
Sbjct: 314 NQ----CHDPNEAAHAVTEQAIQYGTEDNSTAVVVPF 346
>gi|7661862 protein phosphatase 1F [Homo sapiens]
Length = 454
Score = 96.3 bits (238), Expect = 5e-20
Identities = 83/277 (29%), Positives = 134/277 (48%), Gaps = 37/277 (13%)
Query: 99 LSSMQGWRVEMEDAHTAVIGLPS-----GLE---SWSFFAVYDGHAGSQVAKYCCEHLLD 150
+ +++ R +MED H + LPS GL + ++FAV+DGH G A+Y H+
Sbjct: 159 IHAIRNTRRKMEDRH---VSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHV-- 213
Query: 151 HITNNQDFKGSAGAPSVENVKNG-IRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISP 209
+A P + G +R F D+ + + K +SG+T V LI+
Sbjct: 214 -------HTNAARQPELPTDPEGALREAFRRTDQMF--LRKAKRERLQSGTTGVCALIAG 264
Query: 210 QHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAV 266
+ GDS+ +L + +V + H+P EK RI+ GG V RVNG+LAV
Sbjct: 265 ATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAV 324
Query: 267 SRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDF 326
SRA+GD K VS E + + +D +++LACDG +DV+ ++E+
Sbjct: 325 SRAIGDVFQK---------PYVSGEADAASRALTGSED-YLLLACDGFFDVVPHQEVVGL 374
Query: 327 VRSRLEVTDDLE-KVCNEVVDTCLYKGSRDNMSVILI 362
V+S L +V E+V +GS DN++V+++
Sbjct: 375 VQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVV 411
>gi|30089948 protein phosphatase 1E [Homo sapiens]
Length = 755
Score = 93.6 bits (231), Expect = 3e-19
Identities = 77/274 (28%), Positives = 124/274 (45%), Gaps = 31/274 (11%)
Query: 99 LSSMQGWRVEMEDAHTAVIGLP-----SGLESWSFFAVYDGHAGSQVAKYCCEHLLDHIT 153
+ +++ R +MED H + E ++FAV+DGH G A Y HL ++
Sbjct: 234 IHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLHVNLV 293
Query: 154 NNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTY 213
+ F + + F DE R + + + R G+T V I +
Sbjct: 294 RQEMFP--------HDPAEALCRAFRVTDE--RFVQKAARESLRCGTTGVVTFIRGNMLH 343
Query: 214 FINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVM---IQRVNGSLAVSRAL 270
GDS+ +L R + + HKP EK+RI+ GG V+ RVNGSL+VSRA+
Sbjct: 344 VAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAI 403
Query: 271 GDFDYK-CVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRS 329
GD ++K + G + V + + ++ILACDG +D + +E V
Sbjct: 404 GDAEHKPYICGDADSASTV-----------LDGTEDYLILACDGFYDTVNPDEAVKVVSD 452
Query: 330 RL-EVTDDLEKVCNEVVDTCLYKGSRDNMSVILI 362
L E D V +++V + GS DN++VI++
Sbjct: 453 HLKENNGDSSMVAHKLVASARDAGSSDNITVIVV 486
>gi|4505997 protein phosphatase 1D [Homo sapiens]
Length = 605
Score = 87.0 bits (214), Expect = 3e-17
Identities = 87/292 (29%), Positives = 130/292 (44%), Gaps = 53/292 (18%)
Query: 125 SWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEH 184
S +FFAV DGH G + A++ EHL I + F S A ++ G L + +
Sbjct: 97 SVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKK 156
Query: 185 MRVMSEKKHG-ADRSGSTAVGVLISPQHTYFINCGDSRGLL--CRNRKVHF-----FTQD 236
+ + G SG+TA V+I Y + GDS +L + K F TQD
Sbjct: 157 LAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQD 216
Query: 237 HKPSNPLEKERIQNAGGSVM----IQRV---------NGS------------LAVSRALG 271
HKP P E+ERI+ GGSVM + RV NG LAV+RALG
Sbjct: 217 HKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALG 276
Query: 272 D-FDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSR 330
D + Y G E +VSPEP+ + ++IIL DG+W+++ ++ + +
Sbjct: 277 DLWSYDFFSG----EFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQ 332
Query: 331 LE----VTDDLEKVCNEVVDTCLYKGSR-----DNMSVILICFPNAPKVSPE 373
E + + + +V+ L + + DN S I+IC +SPE
Sbjct: 333 EEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVIC------ISPE 378
>gi|149944715 protein phosphatase 1H (PP2C domain containing) [Homo
sapiens]
Length = 514
Score = 50.1 bits (118), Expect = 4e-06
Identities = 29/80 (36%), Positives = 42/80 (52%), Gaps = 3/80 (3%)
Query: 259 RVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEED---DQFIILACDGIW 315
RV ++ V+R LGD D K + +S PEV + S+ D D +ILA DG+W
Sbjct: 381 RVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYDLSKYDHGSDDVLILATDGLW 440
Query: 316 DVMGNEELCDFVRSRLEVTD 335
DV+ NEE+ + + L D
Sbjct: 441 DVLSNEEVAEAITQFLPNCD 460
>gi|171460934 protein phosphatase 1M isoform b [Homo sapiens]
Length = 247
Score = 49.3 bits (116), Expect = 7e-06
Identities = 27/76 (35%), Positives = 46/76 (60%), Gaps = 3/76 (3%)
Query: 259 RVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVH--DIERSE-EDDQFIILACDGIW 315
R+ G+LAVSR LGD + + + + P+V D+++ E ++D +++A DG+W
Sbjct: 116 RLLGTLAVSRGLGDHQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLW 175
Query: 316 DVMGNEELCDFVRSRL 331
DV+ NE++ VRS L
Sbjct: 176 DVLSNEQVAWLVRSFL 191
>gi|171460932 protein phosphatase 1M isoform a [Homo sapiens]
Length = 298
Score = 49.3 bits (116), Expect = 7e-06
Identities = 53/237 (22%), Positives = 92/237 (38%), Gaps = 64/237 (27%)
Query: 154 NNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQ-HT 212
++ F G + + V + + F E DE V+ + + + G V +S Q
Sbjct: 11 SDPQFVEEKGIRAEDLVIGALESAFQECDE---VIGRELEASGQMGGCTALVAVSLQGKL 67
Query: 213 YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQN---------AGGSVMIQ---RV 260
Y N GDSR +L R ++ + + P E++RIQ AG ++ R+
Sbjct: 68 YMANAGDSRAILVRRDEIRPLSFEFTPET--ERQRIQQLAFVYPELLAGEFTRLEFPRRL 125
Query: 261 NGSLAVSRAL----------------GDFDYKCVHGKGPTEQLVS--------------- 289
G + L D Y +HG+G +L+
Sbjct: 126 KGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGDHQLRV 185
Query: 290 --------------PEPEVHDIERSE-EDDQFIILACDGIWDVMGNEELCDFVRSRL 331
P+ V D+++ E ++D +++A DG+WDV+ NE++ VRS L
Sbjct: 186 LDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRSFL 242
>gi|41349497 pyruvate dehydrogenase phosphatase isoenzyme 2 [Homo
sapiens]
Length = 529
Score = 47.8 bits (112), Expect = 2e-05
Identities = 45/172 (26%), Positives = 65/172 (37%), Gaps = 35/172 (20%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFF-----TQDHKPSNPLEKERIQNAG 252
SG+TA + H + N GD R +L + T+DH N E R++
Sbjct: 265 SGATACMAHVDGIHLHVANAGDCRAILGVQEDNGMWSCLPLTRDHNAWNQAELSRLKREH 324
Query: 253 GS------VMIQRVNGSLAVSRALGDFDYKC-------------------VHGKGPTEQL 287
+M R+ G L RA GD K ++ P
Sbjct: 325 PESEDRTIIMEDRLLGVLIPCRAFGDVQLKWSKELQRSILERGFNTEALNIYQFTPPHYY 384
Query: 288 VSP----EPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTD 335
P EPEV R D+F++LA DG+WD++ NE++ V L D
Sbjct: 385 TPPYLTAEPEV-TYHRLRPQDKFLVLASDGLWDMLSNEDVVRLVVGHLAEAD 435
>gi|45439339 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 36/165 (21%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQ--- 249
SG+TA + + N GDSR +L + + DH N E ER++
Sbjct: 270 SGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEH 329
Query: 250 ---NAGGSVMIQRVNGSLAVSRALGDFDYKC-------VHGKGP---------------- 283
A V R+ G L RA GD +K V GP
Sbjct: 330 PKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNY 389
Query: 284 -TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
T ++ EPEV R D+F++LA DG+W+ M +++ V
Sbjct: 390 HTPPYLTAEPEV-TYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433
>gi|239985428 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 3 precursor [Homo sapiens]
Length = 537
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 36/165 (21%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQ--- 249
SG+TA + + N GDSR +L + + DH N E ER++
Sbjct: 270 SGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEH 329
Query: 250 ---NAGGSVMIQRVNGSLAVSRALGDFDYKC-------VHGKGP---------------- 283
A V R+ G L RA GD +K V GP
Sbjct: 330 PKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNY 389
Query: 284 -TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
T ++ EPEV R D+F++LA DG+W+ M +++ V
Sbjct: 390 HTPPYLTAEPEV-TYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 433
>gi|239985426 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 36/165 (21%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQ--- 249
SG+TA + + N GDSR +L + + DH N E ER++
Sbjct: 295 SGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEH 354
Query: 250 ---NAGGSVMIQRVNGSLAVSRALGDFDYKC-------VHGKGP---------------- 283
A V R+ G L RA GD +K V GP
Sbjct: 355 PKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNY 414
Query: 284 -TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
T ++ EPEV R D+F++LA DG+W+ M +++ V
Sbjct: 415 HTPPYLTAEPEV-TYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 458
>gi|239985422 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 2 [Homo sapiens]
Length = 562
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 36/165 (21%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQ--- 249
SG+TA + + N GDSR +L + + DH N E ER++
Sbjct: 295 SGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEH 354
Query: 250 ---NAGGSVMIQRVNGSLAVSRALGDFDYKC-------VHGKGP---------------- 283
A V R+ G L RA GD +K V GP
Sbjct: 355 PKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNY 414
Query: 284 -TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
T ++ EPEV R D+F++LA DG+W+ M +++ V
Sbjct: 415 HTPPYLTAEPEV-TYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 458
>gi|239985420 pyruvate dehyrogenase phosphatase catalytic subunit 1
isoform 1 [Homo sapiens]
Length = 596
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/165 (26%), Positives = 64/165 (38%), Gaps = 36/165 (21%)
Query: 198 SGSTAVGVLISPQHTYFINCGDSRGLLCRNRK-----VHFFTQDHKPSNPLEKERIQ--- 249
SG+TA + + N GDSR +L + + DH N E ER++
Sbjct: 329 SGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEH 388
Query: 250 ---NAGGSVMIQRVNGSLAVSRALGDFDYKC-------VHGKGP---------------- 283
A V R+ G L RA GD +K V GP
Sbjct: 389 PKSEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNY 448
Query: 284 -TEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFV 327
T ++ EPEV R D+F++LA DG+W+ M +++ V
Sbjct: 449 HTPPYLTAEPEV-TYHRLRPQDKFLVLATDGLWETMHRQDVVRIV 492
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 43.5 bits (101), Expect = 4e-04
Identities = 39/148 (26%), Positives = 66/148 (44%), Gaps = 15/148 (10%)
Query: 216 NCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ-RVNGSLAVSRALGDFD 274
N G + +LCRN K ++ + S E +RI+ + +VNG +R LG
Sbjct: 775 NVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILG--- 831
Query: 275 YKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVT 334
Y +H V P P V + + +D+ F IL G+WD + EE + VR+ +
Sbjct: 832 YTFLHPS------VVPRPHVQSVLLTPQDE-FFILGSKGLWDSLSVEEAVEAVRNVPDAL 884
Query: 335 DDLEKVCNEVVDTCLYKGSRDNMSVILI 362
+K+C G D++S +++
Sbjct: 885 AAAKKLCT----LAQSYGCHDSISAVVV 908
>gi|65506328 protein phosphatase 1J (PP2C domain containing) [Homo
sapiens]
Length = 505
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/227 (22%), Positives = 82/227 (36%), Gaps = 65/227 (28%)
Query: 170 VKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRK 229
V + F +DE M E++ G A+ V+ Y N GDSR ++ RN +
Sbjct: 232 VVGAVENAFQLMDEQMA--RERRGHQVEGGCCALVVIYLLGKVYVANAGDSRAIIVRNGE 289
Query: 230 VHFFTQDHKPSNPLEKERIQNAG-------------------------GSVMIQR----- 259
+ +++ P E++R+Q G G M+ R
Sbjct: 290 IIPMSREFTPET--ERQRLQLLGFLKPELLGSEFTHLEFPRRVLPKELGQRMLYRDQNMT 347
Query: 260 -------------------------VNGSLAVSRALGDFDYKCVHGKGPTEQLVS--PEP 292
V ++ V+R LGD K P + +S PE
Sbjct: 348 GWAYKKIELEDLRFPLVCGEGKKARVMATIGVTRGLGDHSLKVCSSTLPIKPFLSCFPEV 407
Query: 293 EVHDIERSEE-DDQFIILACDGIWDVMGNEELC---DFVRSRLEVTD 335
V+D+ + E D ++L DG+WDV + E+ D V S E D
Sbjct: 408 RVYDLTQYEHCPDDVLVLGTDGLWDVTTDCEVAATVDRVLSAYEPND 454
>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 170
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/57 (35%), Positives = 36/57 (63%)
Query: 17 KLMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCERKKYETDLEDQDI 73
K K++K++ K++ KK K+++KKK +R+R KR + K+ ++KK +T E I
Sbjct: 113 KKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRKKKKKKTGNEGAKI 169
Score = 38.1 bits (87), Expect = 0.017
Identities = 16/44 (36%), Positives = 31/44 (70%)
Query: 20 KREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCERKK 63
K +K++ K++ KK K+++KKK ++++ +KR + KR +RKK
Sbjct: 110 KEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKK 153
Score = 34.7 bits (78), Expect = 0.18
Identities = 14/47 (29%), Positives = 32/47 (68%)
Query: 17 KLMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCERKK 63
K K ++++ K++ KK K+++KKK ++++ +K+ + KR +RK+
Sbjct: 105 KKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKR 151
Score = 33.5 bits (75), Expect = 0.41
Identities = 13/44 (29%), Positives = 29/44 (65%)
Query: 20 KREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCERKK 63
+ EK+ K + KK K+++KKK ++++ +K+ + K+ +RK+
Sbjct: 102 REEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKR 145
Score = 31.6 bits (70), Expect = 1.6
Identities = 12/46 (26%), Positives = 31/46 (67%)
Query: 18 LMKREKRRMGKRRAKKAKREEKKKGGERRRNEKRGNQMKRMCERKK 63
L +RE+++ ++ KK K+++KKK ++++ +K+ + K+ ++K
Sbjct: 99 LPQREEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRK 144
>gi|5174703 mitogen-activated protein kinase kinase kinase 7
interacting protein 1 isoform alpha [Homo sapiens]
Length = 504
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/191 (21%), Positives = 77/191 (40%), Gaps = 28/191 (14%)
Query: 178 FLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNR----KVHFF 233
+ +I E ++ + + G G+ AV ++ Y N G +R LLC++ +V
Sbjct: 148 YQKILERLKTLEREISG----GAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQL 203
Query: 234 TQDHKPSNPLEKERIQNAG---GSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQL--- 287
DH N E R+ G G + + +R +G DYK +G + L
Sbjct: 204 NVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIG--DYKVKYGYTDIDLLSAA 261
Query: 288 ----VSPEPEVHDIERSEEDDQFIILACDGIWDVM--------GNEELCDFVRSRLEVTD 335
+ EPE+H + + F++L +G++ + N+E+ + +
Sbjct: 262 KSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQT 321
Query: 336 DLEKVCNEVVD 346
L+ V VVD
Sbjct: 322 SLDAVAQAVVD 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,250,592
Number of Sequences: 37866
Number of extensions: 923446
Number of successful extensions: 5732
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 4402
Number of HSP's gapped (non-prelim): 1007
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.