Search of human proteins with 18496983

Search of human proteins with 18496983

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
sapiens]
         (547 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap...  1121   0.0  
gi|31982881 CAP-GLY domain containing linker protein family, mem...   496   e-140
gi|38044112 restin isoform b [Homo sapiens]                           173   3e-43
gi|4506751 restin isoform a [Homo sapiens]                            173   3e-43
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ...   171   1e-42
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2...   171   1e-42
gi|171184451 centrosome-associated protein 350 [Homo sapiens]          90   6e-18
gi|46852172 kinesin family member 13B [Homo sapiens]                   78   2e-14
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       77   5e-14
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        75   2e-13
gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]           70   6e-12
gi|118442828 beta-tubulin cofactor E [Homo sapiens]                    50   5e-06
gi|4507375 beta-tubulin cofactor E [Homo sapiens]                      50   5e-06
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...    49   2e-05
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...    49   2e-05
gi|53832024 nuclear factor of kappa light polypeptide gene enhan...    47   3e-05
gi|13899229 nuclear factor of kappa light polypeptide gene enhan...    47   3e-05
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         46   1e-04
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         46   1e-04
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    46   1e-04
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...    45   2e-04
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...    45   2e-04
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    45   2e-04
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    45   2e-04
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    44   3e-04
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...    44   5e-04
gi|109637774 ubiquitin carboxyl-terminal hydrolase CYLD isoform ...    43   6e-04
gi|14165258 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1...    43   6e-04
gi|109637776 ubiquitin carboxyl-terminal hydrolase CYLD isoform ...    43   6e-04
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        43   6e-04

>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
           sapiens]
          Length = 547

 Score = 1121 bits (2899), Expect = 0.0
 Identities = 547/547 (100%), Positives = 547/547 (100%)

Query: 1   MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFF 60
           MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFF
Sbjct: 1   MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFF 60

Query: 61  DPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMT 120
           DPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMT
Sbjct: 61  DPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMT 120

Query: 121 LLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVL 180
           LLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVL
Sbjct: 121 LLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVL 180

Query: 181 LKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPD 240
           LKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPD
Sbjct: 181 LKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPD 240

Query: 241 PMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRV 300
           PMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRV
Sbjct: 241 PMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRV 300

Query: 301 LLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKI 360
           LLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKI
Sbjct: 301 LLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKI 360

Query: 361 SKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGD 420
           SKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGD
Sbjct: 361 SKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDGAKAEVGD 420

Query: 421 QVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPAS 480
           QVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPAS
Sbjct: 421 QVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPAS 480

Query: 481 RIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWM 540
           RIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWM
Sbjct: 481 RIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWM 540

Query: 541 LRAEMQS 547
           LRAEMQS
Sbjct: 541 LRAEMQS 547


>gi|31982881 CAP-GLY domain containing linker protein family, member
           4 [Homo sapiens]
          Length = 705

 Score =  496 bits (1277), Expect = e-140
 Identities = 242/394 (61%), Positives = 302/394 (76%), Gaps = 8/394 (2%)

Query: 41  PVVHPSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIG 100
           PV+   + AP+P D  F+FFDPND +CQEILFDP+T++ ELFAI+RQWVPQVQ  ID+IG
Sbjct: 30  PVIFSISAAPMPSDCEFSFFDPNDASCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIG 89

Query: 101 NEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT 160
           NEIL+RGC+VNDRDGLTDMTLLHY CK+GAHG+GD   AV+ + QL+ LGAD++LRSRWT
Sbjct: 90  NEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWT 149

Query: 161 NMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEH 220
           NMNALHYAAYFDVP+L+RV+LK ++P+ V++TCSDFN G+ALHIAA +LC GA KCLLE 
Sbjct: 150 NMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQ 209

Query: 221 GANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNY 280
           GANPA RN KGQ+PA+VVPDP+DM L+ A+AA  AKE++ +L +AVPLSC + K  LPNY
Sbjct: 210 GANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNY 269

Query: 281 DNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVG 340
           D+V G  ML++LGL+LGDRV++ GQK GTLRFCGTTEFASGQW G+ELDEPEGKN+GSVG
Sbjct: 270 DHVTGKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVG 329

Query: 341 GVRYFICPPKQGLFASVSKISKA------VDAPPSSVTSTP--RTPRMDFSRVTGKGRRE 392
            V+YF C PK G+FA +SKISKA      +   PS+  + P  R+ ++D + VT K    
Sbjct: 330 KVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTG 389

Query: 393 HKGKKKTPSSPSLGSLQQRDGAKAEVGDQVLVAG 426
               KK  +S S  SL   +  K      V + G
Sbjct: 390 LMTSKKDSASESTLSLPPGEELKTVTEKDVALLG 423



 Score =  159 bits (402), Expect = 6e-39
 Identities = 84/208 (40%), Positives = 120/208 (57%), Gaps = 21/208 (10%)

Query: 294 LRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGL 353
           LRLG+RVL+ GQ+ GT+RF GTT FA G W G+EL++P GKNDGSVGGV+YF C P+ G+
Sbjct: 485 LRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGI 544

Query: 354 FASVSKISKAVDAPPS------------------SVTSTPRTPRMDFSRVTGKGRREHKG 395
           FA  S++ +  D+  +                  S ++T  + + + +R     + +   
Sbjct: 545 FAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAAL 604

Query: 396 KKKTPSSPSLGSLQQRDGAKAEVGDQVLV-AGQKQGIVRFYGKTDFAPGYWYGIELDQPT 454
           ++   S+P+ G ++     K   G QVL+ +  + G VR+ G TDFA G W G+EL    
Sbjct: 605 RRSWSSTPTAGGIE--GSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAK 662

Query: 455 GKHDGSVFGVRYFTCPPRHGVFAPASRI 482
           GK+DGSV   RYFTC P HGV    SR+
Sbjct: 663 GKNDGSVGDKRYFTCKPNHGVLVRPSRV 690



 Score =  121 bits (303), Expect = 2e-27
 Identities = 68/176 (38%), Positives = 100/176 (56%), Gaps = 15/176 (8%)

Query: 370 SVTSTPRTPRMDFSRVTGKGRREHKGKKKTPS-SPSLGSL--------------QQRDGA 414
           SV+S   T  ++  +   K +      KKT S SPSL S                 R   
Sbjct: 424 SVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSRCEG 483

Query: 415 KAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHG 474
           +  +G++VLV GQ+ G +RF+G T+FAPGYWYGIEL++P GK+DGSV GV+YF+C PR+G
Sbjct: 484 ELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYG 543

Query: 475 VFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISR 530
           +FAP SR+QR+  S D+  +    K+ H     +   + T+  + K+I   N+ S+
Sbjct: 544 IFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSK 599



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 50/122 (40%), Positives = 77/122 (63%), Gaps = 10/122 (8%)

Query: 417 EVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVF 476
           ++GD+V++AGQK G +RF G T+FA G W GIELD+P GK++GSV  V+YF C P++G+F
Sbjct: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343

Query: 477 APASRIQRIGG---------STDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENS 527
           AP S+I +  G         ST +    + ++K+    +T    T   + + KD ASE++
Sbjct: 344 APLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNT-GLMTSKKDSASEST 402

Query: 528 IS 529
           +S
Sbjct: 403 LS 404



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 33/69 (47%), Positives = 45/69 (65%), Gaps = 1/69 (1%)

Query: 294 LRLGDRVLL-DGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQG 352
           L  G +VLL    + GT+R+ G T+FASG W+G+EL   +GKNDGSVG  RYF C P  G
Sbjct: 623 LHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHG 682

Query: 353 LFASVSKIS 361
           +    S+++
Sbjct: 683 VLVRPSRVT 691


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  173 bits (439), Expect = 3e-43
 Identities = 100/256 (39%), Positives = 142/256 (55%), Gaps = 42/256 (16%)

Query: 295 RLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLF 354
           R+G+RV ++G K G ++F G T+FA GQW G+ LDEP GKNDGSV GVRYF C P +G+F
Sbjct: 59  RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118

Query: 355 ASVSKISKAVDAPP----------------------SSVTSTPRTPRMDFSRVTGK-GRR 391
              SK+++ V A                        S V+S+P TP    S +  K  + 
Sbjct: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTP----SNIPQKPSQP 174

Query: 392 EHKGKKKTP--------SSPSLGSLQQRDGAKA-----EVGDQVLVAGQKQGIVRFYGKT 438
             K    TP        +S S+ +L +    K      ++GD+VLV G K G+VRF G+T
Sbjct: 175 AAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGET 234

Query: 439 DFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIG--GSTDSPGDSV 496
           DFA G W G+ELD+P GK+DG+V G RYF C P++G+FAP  ++ +IG   +T +   + 
Sbjct: 235 DFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN 294

Query: 497 GAKKVHQVTMTQPKRT 512
             ++V   T    KR+
Sbjct: 295 AVRRVMATTSASLKRS 310



 Score =  100 bits (248), Expect = 4e-21
 Identities = 59/146 (40%), Positives = 80/146 (54%), Gaps = 9/146 (6%)

Query: 265 AVPLSCALPKVTLPNYDNVP--GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQ 322
           A P    L K    +  N+   G++      L++GDRVL+ G K G +RF G T+FA G+
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 323 WVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDF 382
           W GVELDEP GKNDG+V G RYF C PK GLFA V K++K     PS+  +  +   +  
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI--GFPSTTPAKAKANAVRR 298

Query: 383 SRVTGKGRREHKGKKKTPSSPSLGSL 408
              T          K++PS+ SL S+
Sbjct: 299 VMATTSA-----SLKRSPSASSLSSM 319


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  173 bits (439), Expect = 3e-43
 Identities = 100/256 (39%), Positives = 142/256 (55%), Gaps = 42/256 (16%)

Query: 295 RLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLF 354
           R+G+RV ++G K G ++F G T+FA GQW G+ LDEP GKNDGSV GVRYF C P +G+F
Sbjct: 59  RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118

Query: 355 ASVSKISKAVDAPP----------------------SSVTSTPRTPRMDFSRVTGK-GRR 391
              SK+++ V A                        S V+S+P TP    S +  K  + 
Sbjct: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTP----SNIPQKPSQP 174

Query: 392 EHKGKKKTP--------SSPSLGSLQQRDGAKA-----EVGDQVLVAGQKQGIVRFYGKT 438
             K    TP        +S S+ +L +    K      ++GD+VLV G K G+VRF G+T
Sbjct: 175 AAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGET 234

Query: 439 DFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIG--GSTDSPGDSV 496
           DFA G W G+ELD+P GK+DG+V G RYF C P++G+FAP  ++ +IG   +T +   + 
Sbjct: 235 DFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN 294

Query: 497 GAKKVHQVTMTQPKRT 512
             ++V   T    KR+
Sbjct: 295 AVRRVMATTSASLKRS 310



 Score =  100 bits (248), Expect = 4e-21
 Identities = 59/146 (40%), Positives = 80/146 (54%), Gaps = 9/146 (6%)

Query: 265 AVPLSCALPKVTLPNYDNVP--GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQ 322
           A P    L K    +  N+   G++      L++GDRVL+ G K G +RF G T+FA G+
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240

Query: 323 WVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDF 382
           W GVELDEP GKNDG+V G RYF C PK GLFA V K++K     PS+  +  +   +  
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI--GFPSTTPAKAKANAVRR 298

Query: 383 SRVTGKGRREHKGKKKTPSSPSLGSL 408
              T          K++PS+ SL S+
Sbjct: 299 VMATTSA-----SLKRSPSASSLSSM 319


>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
           [Homo sapiens]
          Length = 1046

 Score =  171 bits (434), Expect = 1e-42
 Identities = 97/230 (42%), Positives = 134/230 (58%), Gaps = 23/230 (10%)

Query: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355
           +G+RV ++G K G +++ G T+FA GQW GV LD+P GKNDG+VGGVRYF CP  QG+F 
Sbjct: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140

Query: 356 SVSKISKAVDAPPS------------------SVTSTPR-TPRMDFSRVTGKGRREHKGK 396
             SK+++   A  S                  S T+TP  T R+   R +        G 
Sbjct: 141 RPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGN 200

Query: 397 KKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGK 456
           +   +    GS++ R      +GD+VLV G K G+VR+ G+TDFA G W G+ELD+P GK
Sbjct: 201 ESGSNLSDSGSVK-RGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGK 259

Query: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTM 506
           +DG+V G RYF CPP+ G+FAP  ++ RIG  + SP     AKK  ++ M
Sbjct: 260 NDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK---AKKTKRMAM 306



 Score =  106 bits (265), Expect = 5e-23
 Identities = 58/124 (46%), Positives = 75/124 (60%), Gaps = 10/124 (8%)

Query: 285 GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRY 344
           G++      LRLGDRVL+ G KTG +R+ G T+FA G+W GVELDEP GKNDG+V G RY
Sbjct: 210 GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 269

Query: 345 FICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPS 404
           F CPPK GLFA + K+ + +  P +S     +T RM      G     H     +PSS S
Sbjct: 270 FQCPPKFGLFAPIHKVIR-IGFPSTSPAKAKKTKRM----AMGVSALTH-----SPSSSS 319

Query: 405 LGSL 408
           + S+
Sbjct: 320 ISSV 323



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 11/152 (7%)

Query: 388 KGRREHKGKKKTPSSPSLGSLQQRDGAKAE-----------VGDQVLVAGQKQGIVRFYG 436
           +G   HK      SSP+  +  ++ G KA            VG++V V G K G+V++ G
Sbjct: 40  EGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLG 99

Query: 437 KTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSV 496
           +T FAPG W G+ LD P GK+DG+V GVRYF CP   G+F   S++ R   +  S  D+ 
Sbjct: 100 ETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAH 159

Query: 497 GAKKVHQVTMTQPKRTFTTVRTPKDIASENSI 528
             + +    ++    T T   T + I    S+
Sbjct: 160 SVESLTAQNLSLHSGTATPPLTSRVIPLRESV 191


>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
           [Homo sapiens]
          Length = 1011

 Score =  171 bits (434), Expect = 1e-42
 Identities = 97/230 (42%), Positives = 134/230 (58%), Gaps = 23/230 (10%)

Query: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355
           +G+RV ++G K G +++ G T+FA GQW GV LD+P GKNDG+VGGVRYF CP  QG+F 
Sbjct: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140

Query: 356 SVSKISKAVDAPPS------------------SVTSTPR-TPRMDFSRVTGKGRREHKGK 396
             SK+++   A  S                  S T+TP  T R+   R +        G 
Sbjct: 141 RPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGN 200

Query: 397 KKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGK 456
           +   +    GS++ R      +GD+VLV G K G+VR+ G+TDFA G W G+ELD+P GK
Sbjct: 201 ESGSNLSDSGSVK-RGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGK 259

Query: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTM 506
           +DG+V G RYF CPP+ G+FAP  ++ RIG  + SP     AKK  ++ M
Sbjct: 260 NDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK---AKKTKRMAM 306



 Score =  106 bits (265), Expect = 5e-23
 Identities = 58/124 (46%), Positives = 75/124 (60%), Gaps = 10/124 (8%)

Query: 285 GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRY 344
           G++      LRLGDRVL+ G KTG +R+ G T+FA G+W GVELDEP GKNDG+V G RY
Sbjct: 210 GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 269

Query: 345 FICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPS 404
           F CPPK GLFA + K+ + +  P +S     +T RM      G     H     +PSS S
Sbjct: 270 FQCPPKFGLFAPIHKVIR-IGFPSTSPAKAKKTKRM----AMGVSALTH-----SPSSSS 319

Query: 405 LGSL 408
           + S+
Sbjct: 320 ISSV 323



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 11/152 (7%)

Query: 388 KGRREHKGKKKTPSSPSLGSLQQRDGAKAE-----------VGDQVLVAGQKQGIVRFYG 436
           +G   HK      SSP+  +  ++ G KA            VG++V V G K G+V++ G
Sbjct: 40  EGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLG 99

Query: 437 KTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSV 496
           +T FAPG W G+ LD P GK+DG+V GVRYF CP   G+F   S++ R   +  S  D+ 
Sbjct: 100 ETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAH 159

Query: 497 GAKKVHQVTMTQPKRTFTTVRTPKDIASENSI 528
             + +    ++    T T   T + I    S+
Sbjct: 160 SVESLTAQNLSLHSGTATPPLTSRVIPLRESV 191


>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
          Length = 3117

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 48/143 (33%), Positives = 78/143 (54%), Gaps = 6/143 (4%)

Query: 354  FASVSKISKAVDAPPSSVTSTPRTPRM-----DFSRVTGKGRREHKGKKKTPSSPSLGSL 408
            F S  +IS+ +     S+ S   + R+         +  K R + + +++   SPSL S+
Sbjct: 2429 FGSNEEISECLSEKSLSIHSNVHSDRLLELKSPTELMKSKERSDVEHEQQVTESPSLASV 2488

Query: 409  QQRDGA-KAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYF 467
               D      +GD+VL+   + GI+RF G+T FA G+W G+ELD+P G ++G+  G+ YF
Sbjct: 2489 PTADELFDFHIGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYF 2548

Query: 468  TCPPRHGVFAPASRIQRIGGSTD 490
             C  +HG+FAP  +I  I  + D
Sbjct: 2549 ECKEKHGIFAPPQKISHIPENFD 2571



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 36/66 (54%), Positives = 44/66 (66%)

Query: 296  LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355
            +GDRVL+   + G LRF G T FA G W GVELD+PEG N+G+  G+ YF C  K G+FA
Sbjct: 2499 IGDRVLIGNVQPGILRFKGETSFAKGFWAGVELDKPEGNNNGTYDGIAYFECKEKHGIFA 2558

Query: 356  SVSKIS 361
               KIS
Sbjct: 2559 PPQKIS 2564


>gi|46852172 kinesin family member 13B [Homo sapiens]
          Length = 1826

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 44/123 (35%), Positives = 58/123 (47%), Gaps = 15/123 (12%)

Query: 294  LRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGL 353
            LR G+ V +   KTG +R+ G  +F  G WVGVELD P GKNDGS+GG +YF C P  GL
Sbjct: 1701 LREGEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGL 1760

Query: 354  FASVSKISKAV---------------DAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKK 398
                S++ +A                +A  S+  S   T     +    K  R HK  + 
Sbjct: 1761 LVRPSRVRRATGPVRRRSTGLRLGAPEARRSATLSGSATNLASLTAALAKADRSHKNPEN 1820

Query: 399  TPS 401
              S
Sbjct: 1821 RKS 1823



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 32/69 (46%), Positives = 44/69 (63%)

Query: 419  GDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAP 478
            G+ V V   K G+VR+ G  DF  G W G+ELD P+GK+DGS+ G +YF C P +G+   
Sbjct: 1704 GEFVTVGAHKTGVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGLLVR 1763

Query: 479  ASRIQRIGG 487
             SR++R  G
Sbjct: 1764 PSRVRRATG 1772


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 47/117 (40%), Positives = 67/117 (57%), Gaps = 5/117 (4%)

Query: 290 SALGLRLGDRVLLDGQ-KTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICP 348
           SA  LR+G RV + G+   GT+ + G T FA+G+WVGV LDE +GKNDG+V G +YF C 
Sbjct: 23  SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCD 82

Query: 349 PKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGK-KKTPSSPS 404
              G+F   S+I    D    + T++P TP    S+V  +   +   K  K P+ P+
Sbjct: 83  EGHGIFVRQSQIQVFED---GADTTSPETPDSSASKVLKREGTDTTAKTSKLPTRPA 136



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 13/128 (10%)

Query: 398 KTPSSPSLGSLQQRDGAKAEVGDQVLVAGQ-KQGIVRFYGKTDFAPGYWYGIELDQPTGK 456
           +TPS   + +  +       VG +V V G+  +G V + G T FA G W G+ LD+  GK
Sbjct: 11  RTPSGSRMSA--EASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGK 68

Query: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQ--RIGGSTDSP--GDSVGAKKVHQVTMTQPKRT 512
           +DG+V G +YFTC   HG+F   S+IQ    G  T SP   DS  +K      + + + T
Sbjct: 69  NDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASK------VLKREGT 122

Query: 513 FTTVRTPK 520
            TT +T K
Sbjct: 123 DTTAKTSK 130


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 48/128 (37%), Positives = 69/128 (53%), Gaps = 9/128 (7%)

Query: 290 SALGLRLGDRVLLDGQ-KTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICP 348
           SA  LR+G RV + G+   GT+ + G T FA+G+WVGV LDE +GKNDG+V G +YF C 
Sbjct: 23  SARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCD 82

Query: 349 PKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSL 408
              G+F   S+I    D    + T++P TP    S+V      + +G   T  +  L  L
Sbjct: 83  EGHGIFVRQSQIQVFED---GADTTSPETPDSSASKVL-----KREGTDTTAKTSKLRGL 134

Query: 409 QQRDGAKA 416
           + +    A
Sbjct: 135 KPKKAPTA 142



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 13/128 (10%)

Query: 398 KTPSSPSLGSLQQRDGAKAEVGDQVLVAGQ-KQGIVRFYGKTDFAPGYWYGIELDQPTGK 456
           +TPS   + +  +       VG +V V G+  +G V + G T FA G W G+ LD+  GK
Sbjct: 11  RTPSGSRMSA--EASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGK 68

Query: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQ--RIGGSTDSP--GDSVGAKKVHQVTMTQPKRT 512
           +DG+V G +YFTC   HG+F   S+IQ    G  T SP   DS  +K      + + + T
Sbjct: 69  NDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASK------VLKREGT 122

Query: 513 FTTVRTPK 520
            TT +T K
Sbjct: 123 DTTAKTSK 130


>gi|50428925 cytoskeleton associated protein 1 [Homo sapiens]
          Length = 244

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 43/135 (31%), Positives = 69/135 (51%), Gaps = 17/135 (12%)

Query: 352 GLFASVSKISK------AVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSL 405
           G +  VS++ K      A D    +V S  +  ++      G+   E + +++  ++  L
Sbjct: 96  GEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKL------GRYNEEERAQQEAEAAQRL 149

Query: 406 GSLQQRDGAKAEVGD--QVLVAGQ--KQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSV 461
              ++   +   VG   +V  AGQ  ++G V + G TDF PGYW G+  D+P GK+DGSV
Sbjct: 150 AE-EKAQASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSV 208

Query: 462 FGVRYFTCPPRHGVF 476
            G RYF C  ++G F
Sbjct: 209 NGKRYFECQAKYGAF 223



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 30/70 (42%), Positives = 39/70 (55%)

Query: 292 LGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQ 351
           +G R   R      + GT+ + G T+F  G W+GV  DEP GKNDGSV G RYF C  K 
Sbjct: 161 VGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKY 220

Query: 352 GLFASVSKIS 361
           G F   + ++
Sbjct: 221 GAFVKPAVVT 230


>gi|118442828 beta-tubulin cofactor E [Homo sapiens]
          Length = 527

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/72 (41%), Positives = 41/72 (56%), Gaps = 3/72 (4%)

Query: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPE-GKNDGSVGGVRYFIC-PPKQGL 353
           +G RV ++G+   T+RF G     +G W+GVE D PE GK+DGS  G  YF C  P  G 
Sbjct: 10  IGRRVEVNGEHA-TVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 354 FASVSKISKAVD 365
           F   +K++   D
Sbjct: 69  FIRPNKVNFGTD 80



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 29/74 (39%), Positives = 35/74 (47%), Gaps = 4/74 (5%)

Query: 418 VGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPT-GKHDGSVFGVRYFTCPPRHGVF 476
           +G +V V G+    VRF G      G W G+E D P  GKHDGS  G  YF C  RH   
Sbjct: 10  IGRRVEVNGE-HATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKC--RHPTG 66

Query: 477 APASRIQRIGGSTD 490
               R  ++   TD
Sbjct: 67  GSFIRPNKVNFGTD 80


>gi|4507375 beta-tubulin cofactor E [Homo sapiens]
          Length = 527

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 30/72 (41%), Positives = 41/72 (56%), Gaps = 3/72 (4%)

Query: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPE-GKNDGSVGGVRYFIC-PPKQGL 353
           +G RV ++G+   T+RF G     +G W+GVE D PE GK+DGS  G  YF C  P  G 
Sbjct: 10  IGRRVEVNGEHA-TVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGS 68

Query: 354 FASVSKISKAVD 365
           F   +K++   D
Sbjct: 69  FIRPNKVNFGTD 80



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 29/74 (39%), Positives = 35/74 (47%), Gaps = 4/74 (5%)

Query: 418 VGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPT-GKHDGSVFGVRYFTCPPRHGVF 476
           +G +V V G+    VRF G      G W G+E D P  GKHDGS  G  YF C  RH   
Sbjct: 10  IGRRVEVNGE-HATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKC--RHPTG 66

Query: 477 APASRIQRIGGSTD 490
               R  ++   TD
Sbjct: 67  GSFIRPNKVNFGTD 80


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
           isoform b [Homo sapiens]
          Length = 1176

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 49/183 (26%), Positives = 76/183 (41%), Gaps = 42/183 (22%)

Query: 92  VQHKIDVIGNEILRRGC-HVNDRDGLTDMTLLHYACKAG---------AHGVGDPAAA-- 139
           V + ++V    + R GC +  + DG    T LH+A K G         + G  D  A   
Sbjct: 693 VNNHLEVARYMVQRGGCVYSKEEDG---STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 749

Query: 140 --------------VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGAR 185
                         + + + LL  GADVTL     N+  LH+A++     +  VLL    
Sbjct: 750 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLL---- 804

Query: 186 PRVVNSTCS----DFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDP 241
               N+ C     +++  + LHIAA           L  GANP LRN++G    ++ P+ 
Sbjct: 805 ----NARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPER 860

Query: 242 MDM 244
            D+
Sbjct: 861 SDV 863


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
           isoform a [Homo sapiens]
          Length = 1210

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 49/183 (26%), Positives = 76/183 (41%), Gaps = 42/183 (22%)

Query: 92  VQHKIDVIGNEILRRGC-HVNDRDGLTDMTLLHYACKAG---------AHGVGDPAAA-- 139
           V + ++V    + R GC +  + DG    T LH+A K G         + G  D  A   
Sbjct: 727 VNNHLEVARYMVQRGGCVYSKEEDG---STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDS 783

Query: 140 --------------VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGAR 185
                         + + + LL  GADVTL     N+  LH+A++     +  VLL    
Sbjct: 784 GGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENI-CLHWASFTGSAAIAEVLL---- 838

Query: 186 PRVVNSTCS----DFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDP 241
               N+ C     +++  + LHIAA           L  GANP LRN++G    ++ P+ 
Sbjct: 839 ----NARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPER 894

Query: 242 MDM 244
            D+
Sbjct: 895 SDV 897


>gi|53832024 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform b [Homo sapiens]
          Length = 618

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/100 (33%), Positives = 53/100 (53%), Gaps = 7/100 (7%)

Query: 146 LLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNST-CSDFNHGSALHI 204
           L+ +GA V  + R +   ALH AA     +L+R+ L+   P  ++      +N  +ALH+
Sbjct: 498 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE--LPSCLSFVNAKAYNGNTALHV 555

Query: 205 AASSLC----LGAAKCLLEHGANPALRNRKGQVPAEVVPD 240
           AAS       L A + L+  GA+P+ RN + + P  +VPD
Sbjct: 556 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 595


>gi|13899229 nuclear factor of kappa light polypeptide gene enhancer
           in B-cells inhibitor, zeta isoform a [Homo sapiens]
          Length = 718

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 33/100 (33%), Positives = 53/100 (53%), Gaps = 7/100 (7%)

Query: 146 LLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNST-CSDFNHGSALHI 204
           L+ +GA V  + R +   ALH AA     +L+R+ L+   P  ++      +N  +ALH+
Sbjct: 598 LIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLE--LPSCLSFVNAKAYNGNTALHV 655

Query: 205 AASSLC----LGAAKCLLEHGANPALRNRKGQVPAEVVPD 240
           AAS       L A + L+  GA+P+ RN + + P  +VPD
Sbjct: 656 AASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPD 695


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/132 (30%), Positives = 64/132 (48%), Gaps = 24/132 (18%)

Query: 140 VRLSQQLLALGADVTLR--SRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFN 197
           V+  ++L++LGA+V ++  + WT ++      Y+DV  ++  +  GA    VN+   D +
Sbjct: 175 VKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL--IAAGAD---VNTQGLDDD 229

Query: 198 HGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKE 257
             + LH +ASS      K LL HG NP   N+ G+ P +V                  +E
Sbjct: 230 --TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE---------------TEE 272

Query: 258 LRTLLEEAVPLS 269
           L  LL+  VPLS
Sbjct: 273 LELLLKREVPLS 284


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/132 (30%), Positives = 64/132 (48%), Gaps = 24/132 (18%)

Query: 140 VRLSQQLLALGADVTLR--SRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFN 197
           V+  ++L++LGA+V ++  + WT ++      Y+DV  ++  +  GA    VN+   D +
Sbjct: 198 VKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL--IAAGAD---VNTQGLDDD 252

Query: 198 HGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKE 257
             + LH +ASS      K LL HG NP   N+ G+ P +V                  +E
Sbjct: 253 --TPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAE---------------TEE 295

Query: 258 LRTLLEEAVPLS 269
           L  LL+  VPLS
Sbjct: 296 LELLLKREVPLS 307


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 9/108 (8%)

Query: 141 RLSQQLLALGADVTLR--SRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNH 198
           R  ++L++ GADV ++  + WT ++      Y+DV    ++L  GA    VN+   D + 
Sbjct: 182 RRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAK--QLLAAGAE---VNTKGLDDD- 235

Query: 199 GSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSL 246
            + LH AA++      K LL +G NP   NRKG+ P +V   P  ++L
Sbjct: 236 -TPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNL 282


>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 5/98 (5%)

Query: 144 QQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALH 203
           ++LLA GAD+   +    + ALH A   +  D+V+ L++       N    D    + LH
Sbjct: 75  RKLLARGADINTVNV-DGLTALHQACIDENLDMVKFLVENR----ANVNQQDNEGWTPLH 129

Query: 204 IAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDP 241
            AAS   L  A+  + HGA+  + N +G+VP+++  +P
Sbjct: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP 167



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 8/127 (6%)

Query: 143 SQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSAL 202
           ++Q L  G    +R   +   ALH AA     +++R+L++      V     D++  + L
Sbjct: 199 ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ----DYDGWTPL 254

Query: 203 HIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLD----KAEAALVAKEL 258
           H AA      A   L E   +  +RN+ GQ P +V  + +   L+    K       KE 
Sbjct: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKET 314

Query: 259 RTLLEEA 265
           R  L E+
Sbjct: 315 RNKLIES 321


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 5/98 (5%)

Query: 144 QQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALH 203
           ++LLA GAD+   +    + ALH A   +  D+V+ L++       N    D    + LH
Sbjct: 75  RKLLARGADINTVNV-DGLTALHQACIDENLDMVKFLVENR----ANVNQQDNEGWTPLH 129

Query: 204 IAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDP 241
            AAS   L  A+  + HGA+  + N +G+VP+++  +P
Sbjct: 130 AAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEP 167



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 8/127 (6%)

Query: 143 SQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSAL 202
           ++Q L  G    +R   +   ALH AA     +++R+L++      V     D++  + L
Sbjct: 199 ARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQ----DYDGWTPL 254

Query: 203 HIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLD----KAEAALVAKEL 258
           H AA      A   L E   +  +RN+ GQ P +V  + +   L+    K       KE 
Sbjct: 255 HAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKET 314

Query: 259 RTLLEEA 265
           R  L E+
Sbjct: 315 RNKLIES 321


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 39/129 (30%), Positives = 61/129 (47%), Gaps = 17/129 (13%)

Query: 109 HVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYA 168
           +V+DR G    T LH+A  +G HG         + + LL+ GA++    +  +  A+H+A
Sbjct: 134 NVSDRAG---RTALHHAAFSG-HG--------EMVKLLLSRGANINAFDK-KDRRAIHWA 180

Query: 169 AYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRN 228
           AY    ++V++L+          TC D    + LH AASS  +   K LL+ G +    N
Sbjct: 181 AYMGHIEVVKLLVSHG----AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPN 236

Query: 229 RKGQVPAEV 237
             G  P  V
Sbjct: 237 AYGNTPLHV 245



 Score = 32.7 bits (73), Expect = 0.88
 Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 6/74 (8%)

Query: 165 LHYAAYFDVPDLVRVL-LKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGAN 223
           LH AAY    +++ +L L GAR   VN+   D    + LH A +S    A + LL+H A+
Sbjct: 45  LHAAAYLGDAEIIELLILSGAR---VNA--KDSKWLTPLHRAVASCSEEAVQVLLKHSAD 99

Query: 224 PALRNRKGQVPAEV 237
              R++  Q P  +
Sbjct: 100 VNARDKNWQTPLHI 113


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 44/136 (32%), Positives = 66/136 (48%), Gaps = 16/136 (11%)

Query: 140 VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHG 199
           + +++ LL  GADV  + +   +  LH AA +   D+  +L+K      VN+T  D    
Sbjct: 692 LEVAEYLLQHGADVNAQDKG-GLIPLHNAASYGHVDVAALLIK--YNACVNAT--DKWAF 746

Query: 200 SALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELR 259
           + LH AA          LL HGA+P L+N++GQ P ++V      S D   A L A    
Sbjct: 747 TPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV------SADDVSALLTA---- 796

Query: 260 TLLEEAVPLSCALPKV 275
            +   A+P SC  P+V
Sbjct: 797 AMPPSALP-SCYKPQV 811



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 33/101 (32%), Positives = 51/101 (50%), Gaps = 5/101 (4%)

Query: 140 VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHG 199
           V + + LL  GADV  + +   +  LH A  +   ++  +L+K     VVN   +D    
Sbjct: 539 VSVVEYLLQHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVKHGA--VVN--VADLWKF 593

Query: 200 SALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPD 240
           + LH AA+       K LL+HGA+P  +NR G  P ++V D
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD 634



 Score = 38.1 bits (87), Expect = 0.021
 Identities = 43/148 (29%), Positives = 64/148 (43%), Gaps = 26/148 (17%)

Query: 103 ILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNM 162
           +++ G  VN  D L   T LH A   G +          + + LL  GAD T ++R  N 
Sbjct: 578 LVKHGAVVNVAD-LWKFTPLHEAAAKGKY---------EICKLLLQHGADPTKKNRDGNT 627

Query: 163 NA-LHYAAYFDVPDLVR---VLLKGAR------------PRVVNSTCSDFNHGSALHIAA 206
              L      D+ DL+R    LL  A+            P  VN   +   H + LH+AA
Sbjct: 628 PLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAA 687

Query: 207 SSLCLGAAKCLLEHGANPALRNRKGQVP 234
               L  A+ LL+HGA+   +++ G +P
Sbjct: 688 GYNNLEVAEYLLQHGADVNAQDKGGLIP 715



 Score = 37.7 bits (86), Expect = 0.027
 Identities = 48/159 (30%), Positives = 71/159 (44%), Gaps = 25/159 (15%)

Query: 110 VNDRDGL-TDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYA 168
           VN RD      T LH+A   G   V          + LL  GA+V  R     +  LH A
Sbjct: 49  VNSRDTAGRKSTPLHFAAGFGRKDV---------VEYLLQNGANVQARDDG-GLIPLHNA 98

Query: 169 AYFDVPDLVRVLLK-GARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALR 227
             F   ++V +LL+ GA P   ++    +N+ + LH AA    +     LL+HGA P +R
Sbjct: 99  CSFGHAEVVNLLLRHGADPNARDN----WNY-TPLHEAAIKGKIDVCIVLLQHGAEPTIR 153

Query: 228 NRKGQVPAEVVPDPMDMSLDKAEAALVAKELR-TLLEEA 265
           N  G+         +D++   A+A L  +  +  LLE A
Sbjct: 154 NTDGRT-------ALDLADPSAKAVLTGEYKKDELLESA 185



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 40/147 (27%), Positives = 65/147 (44%), Gaps = 11/147 (7%)

Query: 101 NEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDP---AAA---VRLSQQLLALGADVT 154
           +E+L      N+   +  +T L+  C A       P   AA    V++ Q LL  GADV 
Sbjct: 179 DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVH 238

Query: 155 LRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAA 214
            + +  ++  LH A  +   ++  +L+K      VN+   D    + LH AAS   +   
Sbjct: 239 AKDKG-DLVPLHNACSYGHYEVTELLVKHGA--CVNAM--DLWQFTPLHEAASKNRVEVC 293

Query: 215 KCLLEHGANPALRNRKGQVPAEVVPDP 241
             LL +GA+P L N   +   ++ P P
Sbjct: 294 SLLLSYGADPTLLNCHNKSAIDLAPTP 320


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 44/152 (28%), Positives = 70/152 (46%), Gaps = 21/152 (13%)

Query: 140 VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHG 199
           + +++ LL  GADV  + +   +  LH AA +   D+  +L+K      VN+T  D    
Sbjct: 850 LEVAEYLLEHGADVNAQDKG-GLIPLHNAASYGHVDIAALLIK--YNTCVNAT--DKWAF 904

Query: 200 SALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELR 259
           + LH AA          LL HGA+P ++N++GQ P ++                 A ++R
Sbjct: 905 TPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA---------------TADDIR 949

Query: 260 TLLEEAVPLSCALPKVTLPNYDNVPGNLMLSA 291
            LL +A+P   ALP    P    V  +L+  A
Sbjct: 950 ALLIDAMPPE-ALPTCFKPQATVVSASLISPA 980



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 66/267 (24%), Positives = 110/267 (41%), Gaps = 34/267 (12%)

Query: 1   MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFF 60
           ++ +  A +AP P G              + SPT      P    S+ A  P+    +  
Sbjct: 108 VSTSSAAGVAPNPAGSGSNNSPSS-----SSSPTSSSSSSPSSPGSSLAESPEAAGVSST 162

Query: 61  DPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGL-TDM 119
            P  P        P T +P +   +R+ +   ++  DV   + L    +VN +D      
Sbjct: 163 APLGPGAA----GPGTGVPAVSGALRELLEACRNG-DVSRVKRLVDAANVNAKDMAGRKS 217

Query: 120 TLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRV 179
           + LH+A   G   V          + LL +GA+V  R     +  LH A  F   ++V +
Sbjct: 218 SPLHFAAGFGRKDV---------VEHLLQMGANVHARDDG-GLIPLHNACSFGHAEVVSL 267

Query: 180 LL-KGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVV 238
           LL +GA P   ++    +N+ + LH AA    +     LL+HGA+P +RN  G+      
Sbjct: 268 LLCQGADPNARDN----WNY-TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGK------ 316

Query: 239 PDPMDMSLDKAEAALVAKELRTLLEEA 265
              +D++   A+A L  +  +  L EA
Sbjct: 317 -SALDLADPSAKAVLTGEYKKDELLEA 342



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/147 (29%), Positives = 65/147 (44%), Gaps = 11/147 (7%)

Query: 101 NEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDP---AAA---VRLSQQLLALGADVT 154
           +E+L      N+   +  +T L+  C A       P   AA    VR+ Q LL  GADV 
Sbjct: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396

Query: 155 LRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAA 214
            + +   +  LH A  +   ++  +LLK      VN+   D    + LH AAS   +   
Sbjct: 397 AKDKG-GLVPLHNACSYGHYEVTELLLKHGA--CVNAM--DLWQFTPLHEAASKNRVEVC 451

Query: 215 KCLLEHGANPALRNRKGQVPAEVVPDP 241
             LL HGA+P L N  G+   ++ P P
Sbjct: 452 SLLLSHGADPTLVNCHGKSAVDMAPTP 478



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 43/148 (29%), Positives = 64/148 (43%), Gaps = 26/148 (17%)

Query: 103 ILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNM 162
           ++R G  VN  D L   T LH A   G +          + + LL  GAD T ++R  N 
Sbjct: 736 LVRHGASVNVAD-LWKFTPLHEAAAKGKY---------EICKLLLKHGADPTKKNRDGNT 785

Query: 163 NA-LHYAAYFDVPDLVR---VLLKGAR------------PRVVNSTCSDFNHGSALHIAA 206
              L      D+ DL+R    LL  A+            P  +N   +   + + LH+AA
Sbjct: 786 PLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAA 845

Query: 207 SSLCLGAAKCLLEHGANPALRNRKGQVP 234
               L  A+ LLEHGA+   +++ G +P
Sbjct: 846 GYNNLEVAEYLLEHGADVNAQDKGGLIP 873



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 9/118 (7%)

Query: 140 VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLK-GARPRVVNSTCSDFNH 198
           V + + LL  GADV  + +   +  LH A  +   ++  +L++ GA   V     +D   
Sbjct: 697 VSVVEYLLHHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVRHGASVNV-----ADLWK 750

Query: 199 GSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVP--DPMDMSLDKAEAALV 254
            + LH AA+       K LL+HGA+P  +NR G  P ++V   D     L + +AAL+
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALL 808



 Score = 29.6 bits (65), Expect = 7.4
 Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 2/47 (4%)

Query: 190 NSTCSDFN--HGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVP 234
           N  C D    H + LH AA    +   + LL HGA+   +++ G VP
Sbjct: 674 NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP 720


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 43/137 (31%), Positives = 61/137 (44%), Gaps = 12/137 (8%)

Query: 116 LTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPD 175
           L +  L+  A   G     DPAA       L +  AD         ++ALH A   +  +
Sbjct: 64  LDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNAD--------GISALHQACIDENLE 115

Query: 176 LVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPA 235
           +VR L++  +   VN   +D    + LH+AAS   L  A+ LL HGAN A  N  G +P 
Sbjct: 116 VVRFLVE--QGATVNQ--ADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPL 171

Query: 236 EVVPDPMDMSLDKAEAA 252
           ++        L KAE A
Sbjct: 172 DLAESDAMEGLLKAEIA 188



 Score = 30.4 bits (67), Expect = 4.4
 Identities = 37/137 (27%), Positives = 56/137 (40%), Gaps = 14/137 (10%)

Query: 135 DPAAAVRLSQQLLAL--------GADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARP 186
           D  AA R  ++LL          GA    R   T  +ALH AA     +++R+LL+    
Sbjct: 193 DVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAG-- 250

Query: 187 RVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSL 246
              +    D +  + LH AA      A + L EHG         GQ P ++  + +   L
Sbjct: 251 --YDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLL 308

Query: 247 DKAEAALVAKELRTLLE 263
           +  E A   ++LR   E
Sbjct: 309 E--ELARKQEDLRNQKE 323


>gi|109637774 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2
           [Homo sapiens]
          Length = 953

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 18/124 (14%)

Query: 290 SALGLRLGDRVLLDGQKTGTLRFCGTT--EFASGQWVGVELDEPEGKNDGSVGGVRYFIC 347
           S + L++G+ +     ++GT+ FC     + + G +VGV++D P G  DG   GV+  +C
Sbjct: 234 SRVSLKVGETI-----ESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQ--LC 286

Query: 348 PPKQGLFASVSK--ISKAVDAPPSSVTSTPRTPRMDF-SRVTG-KGRREHKGKKKTPSSP 403
                 FA V    +    D  P SVT   R P++ F SR  G KG   H   K T S+ 
Sbjct: 287 S-----FACVESTILLHINDIIPESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTS 341

Query: 404 SLGS 407
             G+
Sbjct: 342 DPGN 345



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 20/111 (18%)

Query: 251 AALVAKELRTL-LEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGD--RVLLDGQKT 307
           A  V +EL T  ++E+ PL  A+P          PGN    + GL +G    V  +    
Sbjct: 439 AQSVMEELNTAPVQESPPL--AMP----------PGN----SHGLEVGSLAEVKENPPFY 482

Query: 308 GTLRFCGTTEFASGQWVGVEL-DEPEGKNDGSVGGVRYFICPPKQGLFASV 357
           G +R+ G     +    G+EL DE  G  DG+  G RYF C  K+ LF  +
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKL 533



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 430 GIVRFYGKTDFAPGYWYGIEL-DQPTGKHDGSVFGVRYFTCPPRHGVF 476
           G++R+ G+         G+EL D+  G  DG+  G RYFTC  +  +F
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALF 530


>gi|14165258 ubiquitin carboxyl-terminal hydrolase CYLD isoform 1
           [Homo sapiens]
          Length = 956

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 39/124 (31%), Positives = 59/124 (47%), Gaps = 15/124 (12%)

Query: 290 SALGLRLGDRVLLDGQKTGTLRFCGTT--EFASGQWVGVELDEPEGKNDGSVGGVRY--F 345
           S + L++G+ +     ++GT+ FC     + + G +VGV++D P G  DG   GV+   F
Sbjct: 234 SRVSLKVGETI-----ESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSF 288

Query: 346 ICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDF-SRVTG-KGRREHKGKKKTPSSP 403
            C     L      I+  + A   SVT   R P++ F SR  G KG   H   K T S+ 
Sbjct: 289 ACVESTILL----HINDIIPALSESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTS 344

Query: 404 SLGS 407
             G+
Sbjct: 345 DPGN 348



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 20/111 (18%)

Query: 251 AALVAKELRTL-LEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGD--RVLLDGQKT 307
           A  V +EL T  ++E+ PL  A+P          PGN    + GL +G    V  +    
Sbjct: 442 AQSVMEELNTAPVQESPPL--AMP----------PGN----SHGLEVGSLAEVKENPPFY 485

Query: 308 GTLRFCGTTEFASGQWVGVEL-DEPEGKNDGSVGGVRYFICPPKQGLFASV 357
           G +R+ G     +    G+EL DE  G  DG+  G RYF C  K+ LF  +
Sbjct: 486 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKL 536



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 430 GIVRFYGKTDFAPGYWYGIEL-DQPTGKHDGSVFGVRYFTCPPRHGVF 476
           G++R+ G+         G+EL D+  G  DG+  G RYFTC  +  +F
Sbjct: 486 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALF 533


>gi|109637776 ubiquitin carboxyl-terminal hydrolase CYLD isoform 2
           [Homo sapiens]
          Length = 953

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 40/124 (32%), Positives = 60/124 (48%), Gaps = 18/124 (14%)

Query: 290 SALGLRLGDRVLLDGQKTGTLRFCGTT--EFASGQWVGVELDEPEGKNDGSVGGVRYFIC 347
           S + L++G+ +     ++GT+ FC     + + G +VGV++D P G  DG   GV+  +C
Sbjct: 234 SRVSLKVGETI-----ESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQ--LC 286

Query: 348 PPKQGLFASVSK--ISKAVDAPPSSVTSTPRTPRMDF-SRVTG-KGRREHKGKKKTPSSP 403
                 FA V    +    D  P SVT   R P++ F SR  G KG   H   K T S+ 
Sbjct: 287 S-----FACVESTILLHINDIIPESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTS 341

Query: 404 SLGS 407
             G+
Sbjct: 342 DPGN 345



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 20/111 (18%)

Query: 251 AALVAKELRTL-LEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGD--RVLLDGQKT 307
           A  V +EL T  ++E+ PL  A+P          PGN    + GL +G    V  +    
Sbjct: 439 AQSVMEELNTAPVQESPPL--AMP----------PGN----SHGLEVGSLAEVKENPPFY 482

Query: 308 GTLRFCGTTEFASGQWVGVEL-DEPEGKNDGSVGGVRYFICPPKQGLFASV 357
           G +R+ G     +    G+EL DE  G  DG+  G RYF C  K+ LF  +
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKL 533



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)

Query: 430 GIVRFYGKTDFAPGYWYGIEL-DQPTGKHDGSVFGVRYFTCPPRHGVF 476
           G++R+ G+         G+EL D+  G  DG+  G RYFTC  +  +F
Sbjct: 483 GVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALF 530


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 35/123 (28%), Positives = 58/123 (47%), Gaps = 16/123 (13%)

Query: 116 LTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPD 175
           L   T LH ACK            +++ + L+  GA +   +  + +  +H AA+    +
Sbjct: 375 LNGFTPLHIACKKNR---------IKVMELLVKYGASIQAITE-SGLTPIHVAAFMGHLN 424

Query: 176 LVRVLLK-GARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVP 234
           +V +LL+ GA P V N         +ALH+AA +  +   +CLL +GA    R R+ Q P
Sbjct: 425 IVLLLLQNGASPDVTN-----IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP 479

Query: 235 AEV 237
             +
Sbjct: 480 LHI 482



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 42/138 (30%), Positives = 62/138 (44%), Gaps = 19/138 (13%)

Query: 102 EILRRGCHVN--DRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRW 159
           E L+ G  +N  +++GL     LH A K G  G         L Q+LL  G+ V   ++ 
Sbjct: 28  EYLKGGIDINTCNQNGLN---ALHLAAKEGHVG---------LVQELLGRGSSVDSATKK 75

Query: 160 TNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLE 219
            N  ALH A+     ++V+VL+K       N      N  + L++AA    +   K LLE
Sbjct: 76  GN-TALHIASLAGQAEVVKVLVKEG----ANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 220 HGANPALRNRKGQVPAEV 237
           +GAN +     G  P  V
Sbjct: 131 NGANQSTATEDGFTPLAV 148



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 43/137 (31%), Positives = 63/137 (45%), Gaps = 19/137 (13%)

Query: 103 ILRRGCHVN--DRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT 160
           +L RG  ++   RDGLT    LH A ++G   V          + LL  GA +  R++  
Sbjct: 264 LLDRGGQIDAKTRDGLTP---LHCAARSGHDQV---------VELLLERGAPLLARTK-N 310

Query: 161 NMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEH 220
            ++ LH AA  D  + V+ LL+   P  V+    D+   +ALH+AA        K LL+ 
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAP--VDDVTLDYL--TALHVAAHCGHYRVTKLLLDK 366

Query: 221 GANPALRNRKGQVPAEV 237
            ANP  R   G  P  +
Sbjct: 367 RANPNARALNGFTPLHI 383



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 14/118 (11%)

Query: 120 TLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRV 179
           T LH A +AG          V + + LL  GA V  R+R      LH A+     ++V++
Sbjct: 445 TALHMAARAGQ---------VEVVRCLLRNGALVDARAR-EEQTPLHIASRLGKTEIVQL 494

Query: 180 LLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEV 237
           LL+     + +   +  N  + LHI+A    +  A  LLE GA  +L  +KG  P  V
Sbjct: 495 LLQ----HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHV 548



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 39/135 (28%), Positives = 57/135 (42%), Gaps = 21/135 (15%)

Query: 120 TLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRV 179
           T LH A K G+  V    A + L ++  A  A          +  LH AA++D   +  +
Sbjct: 544 TPLHVAAKYGSLDV----AKLLLQRRAAADSAGKN------GLTPLHVAAHYDNQKVALL 593

Query: 180 LL-KGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVV 238
           LL KGA P          N  + LHIAA    +  A  LL +GA   +  ++G  P  + 
Sbjct: 594 LLEKGASPHATAK-----NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648

Query: 239 -----PDPMDMSLDK 248
                 D + + LDK
Sbjct: 649 SQEGHTDMVTLLLDK 663



 Score = 33.1 bits (74), Expect = 0.67
 Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 21/135 (15%)

Query: 103 ILRRGC--HVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWT 160
           +L +G   H   ++G T    LH A K            ++++  LL  GA+  + ++  
Sbjct: 594 LLEKGASPHATAKNGYTP---LHIAAKKNQ---------MQIASTLLNYGAETNIVTK-Q 640

Query: 161 NMNALHYAAYFDVPDLVRVLL-KGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLE 219
            +  LH A+     D+V +LL KGA   +  ST S     ++LH+AA    +  A  L +
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHM--STKSGL---TSLHLAAQEDKVNVADILTK 695

Query: 220 HGANPALRNRKGQVP 234
           HGA+     + G  P
Sbjct: 696 HGADQDAHTKLGYTP 710



 Score = 32.7 bits (73), Expect = 0.88
 Identities = 33/124 (26%), Positives = 53/124 (42%), Gaps = 11/124 (8%)

Query: 140 VRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHG 199
           V ++  LL  GA  +L ++      LH AA +   D+ ++LL+    R   +  +  N  
Sbjct: 522 VDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQ----RRAAADSAGKNGL 576

Query: 200 SALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDK------AEAAL 253
           + LH+AA       A  LLE GA+P    + G  P  +      M +        AE  +
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636

Query: 254 VAKE 257
           V K+
Sbjct: 637 VTKQ 640


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,573,097
Number of Sequences: 37866
Number of extensions: 1328350
Number of successful extensions: 13583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 255
Number of HSP's that attempted gapping in prelim test: 11224
Number of HSP's gapped (non-prelim): 2006
length of query: 547
length of database: 18,247,518
effective HSP length: 107
effective length of query: 440
effective length of database: 14,195,856
effective search space: 6246176640
effective search space used: 6246176640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.