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Search of human proteins with 111154074
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
(576 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 1150 0.0
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 628 e-180
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 456 e-128
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 396 e-110
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 353 2e-97
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 343 3e-94
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 326 4e-89
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 320 2e-87
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 310 2e-84
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 284 2e-76
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 198 1e-50
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 198 1e-50
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 196 5e-50
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 194 2e-49
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 189 5e-48
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 186 5e-47
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 184 3e-46
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 165 9e-41
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 165 9e-41
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 165 1e-40
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 114 3e-25
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 114 3e-25
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 114 3e-25
gi|95089461 discs large homolog 5 [Homo sapiens] 103 3e-22
gi|10092691 tight junction protein 3 [Homo sapiens] 70 4e-12
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 69 9e-12
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 64 3e-10
gi|8922944 lin-7 homolog C [Homo sapiens] 59 9e-09
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 59 1e-08
gi|9966877 golgi associated PDZ and coiled-coil motif containing... 59 1e-08
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 1150 bits (2976), Expect = 0.0
Identities = 576/576 (100%), Positives = 576/576 (100%)
Query: 1 MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY 60
MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY
Sbjct: 1 MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY 60
Query: 61 EKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYD 120
EKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYD
Sbjct: 61 EKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYD 120
Query: 121 PVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIH 180
PVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIH
Sbjct: 121 PVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIH 180
Query: 181 VGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYN 240
VGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYN
Sbjct: 181 VGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYN 240
Query: 241 PNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLAL 300
PNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLAL
Sbjct: 241 PNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLAL 300
Query: 301 RRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPY 360
RRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPY
Sbjct: 301 RRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPY 360
Query: 361 RRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFI 420
RRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFI
Sbjct: 361 RRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFI 420
Query: 421 SKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFK 480
SKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFK
Sbjct: 421 SKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFK 480
Query: 481 PYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFD 540
PYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFD
Sbjct: 481 PYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFD 540
Query: 541 KIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS 576
KIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS
Sbjct: 541 KIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS 576
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 628 bits (1620), Expect = e-180
Identities = 322/597 (53%), Positives = 434/597 (72%), Gaps = 36/597 (6%)
Query: 1 MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY 60
MP LS D+GL+E LA L +QL+P + +E++ FL D+F EKSL L+KIHEKL YY
Sbjct: 1 MPVLS----EDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYY 56
Query: 61 EKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYD 120
E+QSP P+LH A ALA+D+ EELQ ++S+ RELL+LLS P+++A+L VHDTVAQKN+D
Sbjct: 57 ERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFD 116
Query: 121 PVLPPMPEDIDDE--EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGL 178
PVLPP+P++ID++ E+SVKI+RLVKN+EPLGATI++DE +GA++VARIMRGGAADRSGL
Sbjct: 117 PVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGL 176
Query: 179 IHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFD 238
+HVGDELREVNGI V KRP+EI QILAQSQG+IT KIIP ++EE KE K+F++ALF
Sbjct: 177 VHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFH 236
Query: 239 YNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRL 298
YNP ED+AIPC+EAGL F++ +L+++SQDD TWWQAK D N RAGLIPSK FQERRL
Sbjct: 237 YNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRL 296
Query: 299 ALRR-------PEILVQPL--------------KVSNRKSSGFRKSFRLSRKDKKTNKSM 337
+ RR P+ L +P + +G R+SFRL +++
Sbjct: 297 SYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQ- 355
Query: 338 YECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYG 397
E K S ++ ++ TYEEV Y+ Q E+ RLVVL+G +G L+ELK+K++ + QH+G
Sbjct: 356 -EGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFG 414
Query: 398 VTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLA 457
V VPHTTR R+S E +GVEY F+SK FE D+ +NKF+E+GEYK N YGTS++++++V+A
Sbjct: 415 VAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMA 474
Query: 458 KNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFT 517
KNKVCL+DV+P +K LRT EFKPY+IF+KP ++E RK + + +D A PF
Sbjct: 475 KNKVCLVDVEPEALKQLRTSEFKPYIIFVKP----AIQEKRKTPPMSPACED--TAAPFD 528
Query: 518 EEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWL 574
E+ QEM SA ++ YGHL D +++ +DL A+++LK +KL +THWVPVSW+
Sbjct: 529 EQQ-QEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWV 584
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 456 bits (1172), Expect = e-128
Identities = 245/620 (39%), Positives = 378/620 (60%), Gaps = 52/620 (8%)
Query: 4 LSTGSGSDTGLYELLAALPAQLQPHVDSQED-LTFLWDMFGEKSLHSLVKIHEKLHYYEK 62
LST + GL ++L + +L + + L+D+ L +L+KI++ L +++
Sbjct: 18 LSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKE 77
Query: 63 QSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPV 122
+ VP A L+ ++ E L+ P + EI+EL ++L P+ KALLS HDT+AQK+++P+
Sbjct: 78 KKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPL 137
Query: 123 LPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVG 182
LPP+P++I + E++++I+ LVKN++PLGATIK+ E TG I+VARI+ GG A+RSGL++ G
Sbjct: 138 LPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAG 197
Query: 183 DELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPN 242
D+L EVNG+ VE PE++I ILA S+G I FK++P S S++ ++++A+ +Y P
Sbjct: 198 DKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQ-MVYVRAMTEYWPQ 256
Query: 243 EDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERR----- 297
ED IPC +AGL F+KGDILQI+ Q+DA WWQA+ +D AGL+PS H +R+
Sbjct: 257 EDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFW 316
Query: 298 -----------------------------LALRRPEILVQPLKVSNRKS----------- 317
+ E + ++S K
Sbjct: 317 WSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFI 376
Query: 318 SGFRKSFRL-SRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGP 376
+GFR+S RL RK + C Y P YEEV Y+R+ ++KYRL+VL+GP
Sbjct: 377 AGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAP-YEEVVRYQRRPSDKYRLIVLMGP 435
Query: 377 VGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIE 436
GVG+NEL+R+L+ + H+ VPHTTR ++S E +G EY ++SK FE + +++ +E
Sbjct: 436 SGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLE 495
Query: 437 YGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRE 496
YGEYK + YGTS+D+V++VL + K+C++D++P ++ +RT E KPYVIFIKP ++ +++
Sbjct: 496 YGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQ 555
Query: 497 TRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELK 556
+RKNAK+I+ D F +ED QEM AQ ME+Q+G FD +I+ND L A +L
Sbjct: 556 SRKNAKVIT---DYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLL 612
Query: 557 TTFDKLETETHWVPVSWLHS 576
+ K + E WVP +W+ S
Sbjct: 613 SAIQKAQEEPQWVPATWISS 632
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 396 bits (1018), Expect = e-110
Identities = 222/563 (39%), Positives = 338/563 (60%), Gaps = 50/563 (8%)
Query: 31 SQEDLTFLWDMFGEKSLHSLVKIHEKL--HYYEKQSPVPILHGAAALADDLAEELQN--K 86
SQED++ L + K + KIH + H + P P++ A DLA+E+Q K
Sbjct: 143 SQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNA----QDLAQEVQTVLK 198
Query: 87 PLN-SEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEE------DSVKI 139
P++ E +EL LL+ P+++ALL HD VA++ L P+ ++ E ++VKI
Sbjct: 199 PVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQ--LEPITDERVYESIGQYGGETVKI 256
Query: 140 IRLVKNRE-PLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRP 198
+R+ K R+ PLGAT++ + + +I++RI++GGAA++SGL+H GDE+ E+NGI + K
Sbjct: 257 VRIEKARDIPLGATVRNEMDS--VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDV 314
Query: 199 EEIIQILAQSQGAITFKIIPGSK-EETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFK 257
E+ +L+ G +TF +IP + + P+KE + +KA FDY+P++D +PC+E GLSF+
Sbjct: 315 NEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQ 374
Query: 258 KGDILQIMSQDDATWWQAKHEADAN--PRAGLIPSKHFQERRLALRRPEILVQPLKVSNR 315
KGDIL ++SQ+D WWQA E D + P AGL+P K FQ++R A+++ ++ K +
Sbjct: 375 KGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQT---IEEDKEPEK 431
Query: 316 KSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVG 375
K + + KK K +Y K+D YD ++ TYEE++ Y + N K R ++L+G
Sbjct: 432 SG----KLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRK-RPIILIG 486
Query: 376 PVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFI 435
P G NEL+++L+ + + VPHTTR+RR QE G +Y F+S+ FE D+ KFI
Sbjct: 487 PQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFI 546
Query: 436 EYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLR 495
E+GE++ N YGTSIDSVR V+ K+CLL ++ ++K LR + KPY+IFI PPS ERLR
Sbjct: 547 EHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLR 606
Query: 496 ----ETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVA 551
+ KN K E+ +E+I+ + ME GH FD I+N DL A
Sbjct: 607 ALLAKEGKNPK---------------PEELREIIEKTREMEQNNGHYFDTAIVNSDLDKA 651
Query: 552 FNELKTTFDKLETETHWVPVSWL 574
+ EL +KL+TE WVP +WL
Sbjct: 652 YQELLRLINKLDTEPQWVPSTWL 674
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 353 bits (906), Expect = 2e-97
Identities = 214/585 (36%), Positives = 327/585 (55%), Gaps = 43/585 (7%)
Query: 1 MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY 60
MP +T S +T + ++L L + ++ DL FL + + SL K HE+L
Sbjct: 1 MPVAATNS--ETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERL--- 55
Query: 61 EKQSPVPILHGAAALADDLAEELQN-KPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNY 119
E+ + L ++ +L + +S EL +L +P+ ++LL HD+VA K Y
Sbjct: 56 EETKLEAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTY 115
Query: 120 D-----PVLPPMPEDIDDEEDSVKIIRLVKNR-EPLGATIKKDEQTGAIIVARIMRGGAA 173
+ P L P + D+V+++ + K E LG T + + G +++ARI+ GG
Sbjct: 116 ETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEG--GELVIARILHGGMV 173
Query: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFI 233
+ GL+HVGD ++EVNG PV P + ++L + G++ KI+P +E P ++F+
Sbjct: 174 AQQGLLHVGDIIKEVNGQPVGSD-PRALQELLRNASGSVILKILPSYQE--PHLPRQVFV 230
Query: 234 KALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHF 293
K FDY+P D IPCKEAGL F GD+LQI++QDDA WWQA H + AGLIPS+
Sbjct: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS--AGLIPSQLL 288
Query: 294 QERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPT 353
+E+R A + ++ + P +SG + S KK + MY K+ ++D ++
Sbjct: 289 EEKRKAFVKRDLELTP-------NSG---TLCGSLSGKKKKRMMYLTTKNAEFDRHELLI 338
Query: 354 YEEVT---PYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQ 410
YEEV P+RR+T +VL+G GVG LK KL++ D YG TVP+T+R +
Sbjct: 339 YEEVARMPPFRRKT------LVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDS 392
Query: 411 ESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHT 470
E +G Y F+S+ E DV+ +++E+GEY+ N YGT IDS+R V+A KVC+LDV P
Sbjct: 393 EREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQA 452
Query: 471 VKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQI 530
VK LRT EF PYV+FI+ P E LR + ++ + + K TE D + ++ +
Sbjct: 453 VKVLRTAEFVPYVVFIEAPDFETLRAMNR-----AALESGISTKQLTEADLRRTVEESSR 507
Query: 531 MESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLH 575
++ YGH FD ++N +L F EL+T +KL TE WVPVSW++
Sbjct: 508 IQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 343 bits (879), Expect = 3e-94
Identities = 202/557 (36%), Positives = 310/557 (55%), Gaps = 52/557 (9%)
Query: 34 DLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPL---NS 90
DL FL + + SL K HE+L E + L +++ E++ PL +
Sbjct: 21 DLIFLKGIMENPIVKSLAKAHERL---EDSKLEAVSDNNLELVNEILEDIT--PLINVDE 75
Query: 91 EIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEE--------DSVKIIRL 142
+ EL+ +L +P+ ++LL HD VA K YD PP ++++ D+++I+ +
Sbjct: 76 NVAELVGILKEPHFQSLLEAHDIVASKCYDS--PPSSPEMNNSSINNQLLPVDAIRILGI 133
Query: 143 VKNR-EPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEI 201
K EPLG T + + +++ARI+ GG DR GL+HVGD ++EVNG V + P+E+
Sbjct: 134 HKRAGEPLGVTFRVENND--LVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGNN-PKEL 190
Query: 202 IQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDI 261
++L G++T KI+P ++ ++ +F+K FDYNP D IPCKEAGL F KG+I
Sbjct: 191 QELLKNISGSVTLKILPSYRDTITPQQ--VFVKCHFDYNPYNDNLIPCKEAGLKFSKGEI 248
Query: 262 LQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFR 321
LQI++++D WWQA H + AGLIPS+ +E+R A R + +SG
Sbjct: 249 LQIVNREDPNWWQASHVKEGGS-AGLIPSQFLEEKRKAFVRRDW----------DNSG-- 295
Query: 322 KSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVT---PYRRQTNEKYRLVVLVGPVG 378
F + KK K MY ++ ++D ++ YEEV P++R+T +VL+G G
Sbjct: 296 -PFCGTISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKT------LVLIGAQG 348
Query: 379 VGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYG 438
VG LK + ++ + +G TVP T+R R E DG Y F+S+ E D++ K++E+G
Sbjct: 349 VGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHG 408
Query: 439 EYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETR 498
EY+ N YGT IDS+ V+ + C+LDV P +K LRT EF PYV+FI P +E LR
Sbjct: 409 EYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMH 468
Query: 499 KNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTT 558
K + D K T+ D ++ + + ++ Y H FD IIIND+L AF +L+T
Sbjct: 469 K-----AVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTA 523
Query: 559 FDKLETETHWVPVSWLH 575
+KL E WVP+SW++
Sbjct: 524 IEKLRMEPQWVPISWVY 540
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 326 bits (835), Expect = 4e-89
Identities = 198/578 (34%), Positives = 311/578 (53%), Gaps = 71/578 (12%)
Query: 31 SQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNS 90
S++DL FL +F ++ LH+L+ +++K++ A A ++ EE+ P N+
Sbjct: 358 SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENN 417
Query: 91 EIRELLKLLSKPNVKALLSVHDTVAQKNYDP----VLPP---------MPEDIDDEEDS- 136
+ +EL ++L++P+ ALL HD VA + Y V PP PE + + D
Sbjct: 418 DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDME 477
Query: 137 ----VKIIRLVKNR-EPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGI 191
V++++ KN EP+G T+K +E I VARIM GG R G +HVGDE+RE+NGI
Sbjct: 478 NVTRVRLVQFQKNTDEPMGITLKMNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGI 536
Query: 192 PVEDKRPEEIIQILAQSQGAITFKIIPG------SKEETPS----KEGKMFIKALFDYNP 241
V ++ E++ ++L + +G+ITFKI+P S E+ PS K +++++A F+Y+P
Sbjct: 537 SVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDP 596
Query: 242 NEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALR 301
+D IPCKEAG+ F+ GDI+QI+S+DD WWQ K E N AGLIPS QE R+A
Sbjct: 597 AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVAC- 655
Query: 302 RPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTP-- 359
I ++ K + S + K KK K Y K + +D D+ TYEEV
Sbjct: 656 ---IAMEKTKQEQQASCTW------FGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLP 706
Query: 360 -YRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYI 418
++R+T +VL+G GVG +K L+ + +PHTTR + E +G Y
Sbjct: 707 AFKRKT------LVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY 760
Query: 419 FISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLE 478
F+S D+ NN+++EYG +++ YGT ++++R + + + +LDV+P +K LRT E
Sbjct: 761 FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAE 820
Query: 479 FKPYVIFIKPPSI-ERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGH 537
F P+V+FI P+I L E +E Q + K + I++ Y H
Sbjct: 821 FAPFVVFIAAPTITPGLNE---------------------DESLQRLQKESDILQRTYAH 859
Query: 538 LFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLH 575
FD IIN+++ L+ + + T WVPVSW++
Sbjct: 860 YFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 897
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 320 bits (820), Expect = 2e-87
Identities = 198/578 (34%), Positives = 310/578 (53%), Gaps = 76/578 (13%)
Query: 31 SQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNS 90
S++DL FL +F ++ LH+L+ +++K++ A A ++ EE+ P N+
Sbjct: 364 SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENN 423
Query: 91 EIRELLKLLSKPNVKALLSVHDTVAQKNYDP----VLPP---------MPEDIDDEEDS- 136
+ +EL ++L++P+ ALL HD VA + Y V PP PE + + D
Sbjct: 424 DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDME 483
Query: 137 ----VKIIRLVKNR-EPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGI 191
V++++ KN EP+G T+K +E I VARIM GG R G +HVGDE+RE+NGI
Sbjct: 484 NVTRVRLVQFQKNTDEPMGITLKMNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGI 542
Query: 192 PVEDKRPEEIIQILAQSQGAITFKIIPG------SKEETPS----KEGKMFIKALFDYNP 241
V ++ E++ ++L + +G+ITFKI+P S E+ PS K +++++A F+Y+P
Sbjct: 543 SVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDP 602
Query: 242 NEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALR 301
+D IPCKEAG+ F+ GDI+QI+S+DD WWQ K E N AGLIPS QE R+A
Sbjct: 603 AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVAC- 661
Query: 302 RPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTP-- 359
I ++ K + S + K KK K Y K + AD+ TYEEV
Sbjct: 662 ---IAMEKTKQEQQASCTW------FGKKKKQYKDKYLAKHN-----ADLVTYEEVVKLP 707
Query: 360 -YRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYI 418
++R+T +VL+G GVG +K L+ + +PHTTR + E +G Y
Sbjct: 708 AFKRKT------LVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYY 761
Query: 419 FISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLE 478
F+S D+ NN+++EYG +++ YGT ++++R + + + +LDV+P +K LRT E
Sbjct: 762 FVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAE 821
Query: 479 FKPYVIFIKPPSI-ERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGH 537
F P+V+FI P+I L E +E Q + K + I++ Y H
Sbjct: 822 FAPFVVFIAAPTITPGLNE---------------------DESLQRLQKESDILQRTYAH 860
Query: 538 LFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLH 575
FD IIN+++ L+ + + T WVPVSW++
Sbjct: 861 YFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 898
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 310 bits (795), Expect = 2e-84
Identities = 195/601 (32%), Positives = 309/601 (51%), Gaps = 99/601 (16%)
Query: 31 SQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNS 90
S++DL FL +F ++ LH+L+ +++K++ A A ++ EE+ P N+
Sbjct: 364 SEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENN 423
Query: 91 EIRELLKLLSKPNVKALLSVHDTVAQKNYDP----VLPP---------MPEDIDDEEDS- 136
+ +EL ++L++P+ ALL HD VA + Y V PP PE + + D
Sbjct: 424 DAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDME 483
Query: 137 ----VKIIRLVKNR-EPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGI 191
V++++ KN EP+G T+K +E I VARIM GG R G +HVGDE+RE+NGI
Sbjct: 484 NVTRVRLVQFQKNTDEPMGITLKMNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGI 542
Query: 192 PVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPS------------------------- 226
V ++ E++ ++L + +G+ITFKI+P + ++ S
Sbjct: 543 SVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVS 602
Query: 227 --------KEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHE 278
K +++++A F+Y+P +D IPCKEAG+ F+ GDI+QI+S+DD WWQ K E
Sbjct: 603 DLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLE 662
Query: 279 ADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMY 338
N AGLIPS QE R+A I ++ K + S + K KK K Y
Sbjct: 663 NSKNGTAGLIPSPELQEWRVAC----IAMEKTKQEQQASCTW------FGKKKKQYKDKY 712
Query: 339 ECKKSDQYDTADVPTYEEVTP---YRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQH 395
K + AD+ TYEEV ++R+T +VL+G GVG +K L+
Sbjct: 713 LAKHN-----ADLVTYEEVVKLPAFKRKT------LVLLGAHGVGRRHIKNTLITKHPDR 761
Query: 396 YGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSV 455
+ +PHTTR + E +G Y F+S D+ NN+++EYG +++ YGT ++++R +
Sbjct: 762 FAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKI 821
Query: 456 LAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSI-ERLRETRKNAKIISSRDDQGAAK 514
+ + +LDV+P +K LRT EF P+V+FI P+I L E
Sbjct: 822 HEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNE------------------ 863
Query: 515 PFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWL 574
+E Q + K + I++ Y H FD IIN+++ L+ + + T WVPVSW+
Sbjct: 864 ---DESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 920
Query: 575 H 575
+
Sbjct: 921 Y 921
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 284 bits (726), Expect = 2e-76
Identities = 166/488 (34%), Positives = 259/488 (53%), Gaps = 48/488 (9%)
Query: 92 IRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVK----NRE 147
+ LL+ S+P +A+ +TV + Y P + V+ +RL++ E
Sbjct: 23 LEHLLQKRSRP--EAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEE 80
Query: 148 PLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQ 207
P+G T+K +E+ VARI+ GG R G +HVGDE+ E+NG V + +++ + + +
Sbjct: 81 PMGITLKLNEKQSCT-VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKE 139
Query: 208 SQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQ 267
++G I+ K+IP + P+ + MF++A FDY+P +D IPCKEAGL F GDI+QI+++
Sbjct: 140 TKGMISLKVIPNQQSRLPALQ--MFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINK 197
Query: 268 DDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLS 327
DD+ WWQ + E + AGLIPS QE R+A + Q S F K
Sbjct: 198 DDSNWWQGRVEGSSKESAGLIPSPELQEWRVAS-----MAQSAPSEAPSCSPFGK----- 247
Query: 328 RKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRK 387
KK K Y K S +D DV +YEEV R K + +VL+G GVG + +K
Sbjct: 248 ---KKKYKDKYLAKHSSIFDQLDVVSYEEVV---RLPAFKRKTLVLIGASGVGRSHIKNA 301
Query: 388 LLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGT 447
LL + + + VP+TTR R E DG EY FIS ++ N+F+E+G Y+ N +GT
Sbjct: 302 LLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGT 361
Query: 448 SIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSR 507
++V + +NK+ +LD++P T+K +RT E P+++FI P
Sbjct: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP------------------- 402
Query: 508 DDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETH 567
DQG E Q++ K ++ + SQY H FD ++N+ + +L+ FD+ +
Sbjct: 403 TDQGT----QTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQ 458
Query: 568 WVPVSWLH 575
WVPVSW++
Sbjct: 459 WVPVSWVY 466
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 198 bits (504), Expect = 1e-50
Identities = 149/479 (31%), Positives = 229/479 (47%), Gaps = 71/479 (14%)
Query: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193
E + + L K LG I E I V+ I+ GG AD SG + GD++ VNGI +
Sbjct: 521 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 580
Query: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227
E+ + I+AQ Q + + GS ++
Sbjct: 581 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 640
Query: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284
+ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+ E D+
Sbjct: 641 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 697
Query: 285 AGLIPSKHFQER--RLALRRPEILVQPLKVSNRKSSGFR--KSFRLSRKDKKTNKSMYEC 340
G+IPSK ER R L+ + +P + ++ S + KSF SRK Y+
Sbjct: 698 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFP-----FYKN 752
Query: 341 KKSDQYDTAD--------VPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISD 392
K+ + +T+D + +YE VT RQ R V+++GP+ +N+ L+
Sbjct: 753 KEQSEQETSDPERGQEDLILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEF 806
Query: 393 TQHYGVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDS 451
+G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YGTS+ S
Sbjct: 807 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQS 866
Query: 452 VRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQG 511
VR V + K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 867 VRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR----------- 915
Query: 512 AAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
TEE ++ A +E ++G F I+ D L +N+ K ++ W+P
Sbjct: 916 ----LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 970
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
++V I+L K + LG +I + +I V +I+ GGAA + G + VGD L V
Sbjct: 294 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 353
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N +E+ EE + IL + + K+
Sbjct: 354 NNYSLEEVTHEEAVAILKNTSEVVYLKV 381
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 198 bits (504), Expect = 1e-50
Identities = 149/479 (31%), Positives = 229/479 (47%), Gaps = 71/479 (14%)
Query: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193
E + + L K LG I E I V+ I+ GG AD SG + GD++ VNGI +
Sbjct: 416 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 475
Query: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227
E+ + I+AQ Q + + GS ++
Sbjct: 476 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 535
Query: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284
+ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+ E D+
Sbjct: 536 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 592
Query: 285 AGLIPSKHFQER--RLALRRPEILVQPLKVSNRKSSGFR--KSFRLSRKDKKTNKSMYEC 340
G+IPSK ER R L+ + +P + ++ S + KSF SRK Y+
Sbjct: 593 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFP-----FYKN 647
Query: 341 KKSDQYDTAD--------VPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISD 392
K+ + +T+D + +YE VT RQ R V+++GP+ +N+ L+
Sbjct: 648 KEQSEQETSDPERGQEDLILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEF 701
Query: 393 TQHYGVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDS 451
+G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YGTS+ S
Sbjct: 702 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQS 761
Query: 452 VRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQG 511
VR V + K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 762 VRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR----------- 810
Query: 512 AAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
TEE ++ A +E ++G F I+ D L +N+ K ++ W+P
Sbjct: 811 ----LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 865
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
++V I+L K + LG +I + +I V +I+ GGAA + G + VGD L V
Sbjct: 189 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 248
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N +E+ EE + IL + + K+
Sbjct: 249 NNYSLEEVTHEEAVAILKNTSEVVYLKV 276
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 196 bits (498), Expect = 5e-50
Identities = 155/492 (31%), Positives = 226/492 (45%), Gaps = 80/492 (16%)
Query: 132 DEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGI 191
D + KII L K LG I E I V+ I+ GG AD SG + GD + VNG+
Sbjct: 43 DAREPRKII-LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGV 101
Query: 192 PVEDKRPEEIIQILAQSQGAITF--------------------------KIIPGSKEETP 225
+ + E+ L ++ ++T + GS
Sbjct: 102 NLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRT 161
Query: 226 SKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEAD--ANP 283
S++ ++++ALFDY+ D +P + GLSF GDIL +++ D WWQA+ +
Sbjct: 162 SEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESE 219
Query: 284 RAGLIPSKHFQERRLALRRPEILVQP---LKVSNRKSSGFRK-SFRLSRK---------- 329
+ G+IPSK E++ R + + SNR RK SFRLSRK
Sbjct: 220 QIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENM 279
Query: 330 ---------DKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVG 380
+N S E Q D + +YE VT RQ R V+++GP+
Sbjct: 280 AQESSIQEQGVTSNTSDSESSSKGQEDA--ILSYEPVT---RQEIHYARPVIILGPMKDR 334
Query: 381 LNELKRKLLISDTQH-YGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKFIEYG 438
+N+ LIS+ H +G VPHTTR RR E DG +Y F+ S+ E D+Q+NKFIE G
Sbjct: 335 VNDD----LISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAG 390
Query: 439 EYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETR 498
++ +N YGTSI SVR+V + K C+LDV + +K L+ + P IFIKP SIE L E
Sbjct: 391 QFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMN 450
Query: 499 KNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTT 558
+ T E ++ A +E ++G F I+ D L +N++K
Sbjct: 451 RRQ---------------TYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQI 495
Query: 559 FDKLETETHWVP 570
+ WVP
Sbjct: 496 IEDQSGHYIWVP 507
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 194 bits (492), Expect = 2e-49
Identities = 163/547 (29%), Positives = 243/547 (44%), Gaps = 82/547 (14%)
Query: 57 LHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQ 116
LH + +P ALAD+ NS + L + SK + A V T
Sbjct: 315 LHLNDMYAPPDYASTFTALADNHISH------NSSLGYLGAVESKVSYPAPPQVPPT--- 365
Query: 117 KNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRS 176
Y P+ M + D + KII L K LG I E I V+ I+ GG AD S
Sbjct: 366 -RYSPIPRHMLAEEDFTREPRKII-LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLS 423
Query: 177 GLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITF---------------------- 214
G + GD + VNG+ + + E+ L ++ ++T
Sbjct: 424 GELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQ 483
Query: 215 ----KIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDA 270
+ GS S++ ++++ALFDY+ D +P + GLSF GDIL +++ D
Sbjct: 484 MMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDD 541
Query: 271 TWWQAKHEAD--ANPRAGLIPSKHFQERRLALRRPEILVQP---LKVSNRKSSGFRKSFR 325
WWQA+ + + G+IPSK E++ R + + SNR G +
Sbjct: 542 EWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDY- 600
Query: 326 LSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELK 385
Y K + A + +YE VT RQ R V+++GP+ +N+
Sbjct: 601 ------------YGAKNLKGQEDA-ILSYEPVT---RQEIHYARPVIILGPMKDRVNDD- 643
Query: 386 RKLLISDTQH-YGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKFIEYGEYKNN 443
LIS+ H +G VPHTTR RR E DG +Y F+ S+ E D+Q+NKFIE G++ +N
Sbjct: 644 ---LISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDN 700
Query: 444 YYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKI 503
YGTSI SVR+V + K C+LDV + +K L+ + P IFIKP SIE L E +
Sbjct: 701 LYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ-- 758
Query: 504 ISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLE 563
T E ++ A +E ++G F I+ D L +N++K +
Sbjct: 759 -------------TYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQS 805
Query: 564 TETHWVP 570
WVP
Sbjct: 806 GHYIWVP 812
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/136 (22%), Positives = 63/136 (46%), Gaps = 7/136 (5%)
Query: 92 IRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGA 151
+ + + +++ +V ++ A K PV+ + +++ + L+K + LG
Sbjct: 179 VNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGF 238
Query: 152 TI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQIL 205
+I + +I + +I+ GGAA + G + +GD L VN ++D R EE + L
Sbjct: 239 SIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASL 298
Query: 206 AQSQGAITFKII-PGS 220
+ + K+ PGS
Sbjct: 299 KNTSDMVYLKVAKPGS 314
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 189 bits (481), Expect = 5e-48
Identities = 142/496 (28%), Positives = 223/496 (44%), Gaps = 65/496 (13%)
Query: 119 YDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGL 178
Y PV + D + + K++ L + LG I E I ++ I+ GG AD SG
Sbjct: 447 YSPVSKAVLGDDEITREPRKVV-LHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGE 505
Query: 179 IHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITF------------------------ 214
+ GD + VN + + E+ L + A+T
Sbjct: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMM 565
Query: 215 --KIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATW 272
I GS S++ ++++ALFDY+ +D +P + GL+FK GDIL +++ D W
Sbjct: 566 NSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEW 623
Query: 273 WQAKHEAD--ANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKS-SGFRKSFRLSRK 329
WQA+ + G+IPSK E++ R + +S + RK SRK
Sbjct: 624 WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRK 683
Query: 330 D---KKTNKSMYECKKSDQYDTADVPTYEE-----------VTPYRRQTNEKYRLVVLVG 375
K ++S E +DQ+ T++ E P +Q R V+++G
Sbjct: 684 FPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILG 743
Query: 376 PVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKF 434
P+ +N+ L+ +G VPHTTR +R E DG +Y F+ S+ E D+Q +KF
Sbjct: 744 PMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKF 800
Query: 435 IEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERL 494
IE G+Y N+ YGTS+ SVR V K K C+LDV + +K L+ + P IFIKP S+E +
Sbjct: 801 IEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI 860
Query: 495 RETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNE 554
E K TEE ++ + A +E ++ F I+ D L +N+
Sbjct: 861 MEMNKR---------------LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQ 905
Query: 555 LKTTFDKLETETHWVP 570
+K ++ WVP
Sbjct: 906 VKQIIEEQSGSYIWVP 921
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
+ + I+L+K + LG +I + +I V +I+ GGAA + G + +GD+L V
Sbjct: 315 EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N + +E+ EE + L + + K+
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 186 bits (472), Expect = 5e-47
Identities = 137/481 (28%), Positives = 217/481 (45%), Gaps = 57/481 (11%)
Query: 119 YDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGL 178
Y PV + D + + K++ L + LG I E I ++ I+ GG AD SG
Sbjct: 447 YSPVSKAVLGDDEITREPRKVV-LHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGE 505
Query: 179 IHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITF------------------------ 214
+ GD + VN + + E+ L + A+T
Sbjct: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMM 565
Query: 215 --KIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATW 272
I GS S++ ++++ALFDY+ +D +P + GL+FK GDIL +++ D W
Sbjct: 566 NSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEW 623
Query: 273 WQAKHEAD--ANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKD 330
WQA+ + G+IPSK E++ R + S + G S+
Sbjct: 624 WQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFN----SKTRDKGEIPDDMGSKGL 679
Query: 331 KKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLI 390
K + + + S + V +YE P +Q R V+++GP+ +N+ L+
Sbjct: 680 KHVTSNASDSESSYRGQEEYVLSYE---PVNQQEVNYTRPVIILGPMKDRIND---DLIS 733
Query: 391 SDTQHYGVTVPHTTRARRSQESDGVEYIFI-SKHLFETDVQNNKFIEYGEYKNNYYGTSI 449
+G VPHTTR +R E DG +Y F+ S+ E D+Q +KFIE G+Y N+ YGTS+
Sbjct: 734 EFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSV 793
Query: 450 DSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDD 509
SVR V K K C+LDV + +K L+ + P IFIKP S+E + E K
Sbjct: 794 QSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR--------- 844
Query: 510 QGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWV 569
TEE ++ + A +E ++ F I+ D L +N++K ++ WV
Sbjct: 845 ------LTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWV 898
Query: 570 P 570
P
Sbjct: 899 P 899
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
+ + I+L+K + LG +I + +I V +I+ GGAA + G + +GD+L V
Sbjct: 315 EKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N + +E+ EE + L + + K+
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 184 bits (466), Expect = 3e-46
Identities = 139/475 (29%), Positives = 215/475 (45%), Gaps = 81/475 (17%)
Query: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193
E + + L K LG I E I V+ I+ GG AD SG + GD++ VNGI +
Sbjct: 313 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 372
Query: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227
E+ + I+AQ Q + + GS ++
Sbjct: 373 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 432
Query: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284
+ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+ E D+
Sbjct: 433 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 489
Query: 285 AGLIPSKHFQERRLALR--------RPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKS 336
G+IPSK ER+ R +P ++ + G+ ++D
Sbjct: 490 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDL----- 544
Query: 337 MYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHY 396
+ +YE VT RQ R V+++GP+ +N+ L+ +
Sbjct: 545 --------------ILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEFPDKF 584
Query: 397 GVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSV 455
G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YGTS+ SVR V
Sbjct: 585 GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
Query: 456 LAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKP 515
+ K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 645 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR--------------- 689
Query: 516 FTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
TEE ++ A +E ++G F I+ D L +N+ K ++ W+P
Sbjct: 690 LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
++V I+L K + LG +I + +I V +I+ GGAA + G + VGD L V
Sbjct: 138 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 197
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N +E+ EE + IL + + K+
Sbjct: 198 NNYSLEEVTHEEAVAILKNTSEVVYLKV 225
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 165 bits (418), Expect = 9e-41
Identities = 136/480 (28%), Positives = 203/480 (42%), Gaps = 90/480 (18%)
Query: 125 PMPEDIDDEEDSVKIIRLV---KNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHV 181
P+ +D+ EED + R + + LG I E I ++ I+ GG AD SG +
Sbjct: 339 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 398
Query: 182 GDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKM---------- 231
GD++ VNG+ + + E+ L + +T I EE E K+
Sbjct: 399 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNS 457
Query: 232 -----------------FIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQ 274
+I+ALFDY+ +D + LSF+ GD+L ++ D WWQ
Sbjct: 458 SLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQ 515
Query: 275 AK--HEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKK 332
A+ H G IPSK ERR + RL KD
Sbjct: 516 ARRVHSDSETDDIGFIPSKRRVERR------------------------EWSRLKAKD-- 549
Query: 333 TNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-RLVVLVGPVGVGLNELKRKLLIS 391
+ Q V +YE VT Q Y R ++++GP N+ LL
Sbjct: 550 -----WGSSSGSQGREDSVLSYETVT----QMEVHYARPIIILGPTKDRAND---DLLSE 597
Query: 392 DTQHYGVTVPHTTRARRSQESDGVEYIFIS-KHLFETDVQNNKFIEYGEYKNNYYGTSID 450
+G VPHTTR +R E DG +Y F+S + E D+Q +KFIE G+Y ++ YGTS+
Sbjct: 598 FPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQ 657
Query: 451 SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQ 510
SVR V + K C+LDV + V+ L+ P IFI+P S+E + E K
Sbjct: 658 SVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR---------- 707
Query: 511 GAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
TEE ++ A +E ++ F I+ D ++++K + L WVP
Sbjct: 708 -----ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 762
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
+ V I+L+K + LG +I + +I V +I+ GGAA + G + +GD++ V
Sbjct: 199 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 258
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N + +ED E+ + L + + K+
Sbjct: 259 NSVGLEDVMHEDAVAALKNTYDVVYLKV 286
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 165 bits (418), Expect = 9e-41
Identities = 136/480 (28%), Positives = 203/480 (42%), Gaps = 90/480 (18%)
Query: 125 PMPEDIDDEEDSVKIIRLV---KNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHV 181
P+ +D+ EED + R + + LG I E I ++ I+ GG AD SG +
Sbjct: 293 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 352
Query: 182 GDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKM---------- 231
GD++ VNG+ + + E+ L + +T I EE E K+
Sbjct: 353 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNS 411
Query: 232 -----------------FIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQ 274
+I+ALFDY+ +D + LSF+ GD+L ++ D WWQ
Sbjct: 412 SLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQ 469
Query: 275 AK--HEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKK 332
A+ H G IPSK ERR + RL KD
Sbjct: 470 ARRVHSDSETDDIGFIPSKRRVERR------------------------EWSRLKAKD-- 503
Query: 333 TNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-RLVVLVGPVGVGLNELKRKLLIS 391
+ Q V +YE VT Q Y R ++++GP N+ LL
Sbjct: 504 -----WGSSSGSQGREDSVLSYETVT----QMEVHYARPIIILGPTKDRAND---DLLSE 551
Query: 392 DTQHYGVTVPHTTRARRSQESDGVEYIFIS-KHLFETDVQNNKFIEYGEYKNNYYGTSID 450
+G VPHTTR +R E DG +Y F+S + E D+Q +KFIE G+Y ++ YGTS+
Sbjct: 552 FPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQ 611
Query: 451 SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQ 510
SVR V + K C+LDV + V+ L+ P IFI+P S+E + E K
Sbjct: 612 SVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR---------- 661
Query: 511 GAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
TEE ++ A +E ++ F I+ D ++++K + L WVP
Sbjct: 662 -----ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
+ V I+L+K + LG +I + +I V +I+ GGAA + G + +GD++ V
Sbjct: 153 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 212
Query: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
N + +ED E+ + L + + K+
Sbjct: 213 NSVGLEDVMHEDAVAALKNTYDVVYLKV 240
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 165 bits (417), Expect = 1e-40
Identities = 112/364 (30%), Positives = 175/364 (48%), Gaps = 55/364 (15%)
Query: 219 GSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH- 277
GS +++ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+
Sbjct: 9 GSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRV 66
Query: 278 --EADANPRAGLIPSKHFQERRLALR--------RPEILVQPLKVSNRKSSGFRKSFRLS 327
E D+ G+IPSK ER+ R +P ++ + G+
Sbjct: 67 MLEGDSE-EMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRG 125
Query: 328 RKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRK 387
++D + +YE VT RQ R V+++GP+ +N+
Sbjct: 126 QEDL-------------------ILSYEPVT---RQEINYTRPVIILGPMKDRIND---D 160
Query: 388 LLISDTQHYGVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYG 446
L+ +G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YG
Sbjct: 161 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 220
Query: 447 TSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISS 506
TS+ SVR V + K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 221 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR------ 274
Query: 507 RDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETET 566
TEE ++ A +E ++G F I+ D L +N+ K ++
Sbjct: 275 ---------LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPF 325
Query: 567 HWVP 570
W+P
Sbjct: 326 IWIP 329
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 114 bits (284), Expect = 3e-25
Identities = 66/190 (34%), Positives = 108/190 (56%), Gaps = 14/190 (7%)
Query: 369 RLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETD 428
R VVL GP G G + L ++LL + +G +V HTTR R E +G +Y F+++ + + D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 429 VQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKP 488
+ FIE+ E+ N YGTS +V++V A N++C+LDV V++++ + +P I ++P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 489 PSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQ--IMESQYGHLFDKIIIND 546
PS+ L + + R+ + TEE + + +AQ + S+ LFD +IIND
Sbjct: 125 PSLHVLEQR------LRQRNTE------TEESLVKRLAAAQADMESSKEPGLFDVVIIND 172
Query: 547 DLTVAFNELK 556
L A+ ELK
Sbjct: 173 SLDQAYAELK 182
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 114 bits (284), Expect = 3e-25
Identities = 66/190 (34%), Positives = 108/190 (56%), Gaps = 14/190 (7%)
Query: 369 RLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETD 428
R VVL GP G G + L ++LL + +G +V HTTR R E +G +Y F+++ + + D
Sbjct: 26 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 85
Query: 429 VQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKP 488
+ FIE+ E+ N YGTS +V++V A N++C+LDV V++++ + +P I ++P
Sbjct: 86 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 145
Query: 489 PSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQ--IMESQYGHLFDKIIIND 546
PS+ L + + R+ + TEE + + +AQ + S+ LFD +IIND
Sbjct: 146 PSLHVLEQR------LRQRNTE------TEESLVKRLAAAQADMESSKEPGLFDVVIIND 193
Query: 547 DLTVAFNELK 556
L A+ ELK
Sbjct: 194 SLDQAYAELK 203
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 114 bits (284), Expect = 3e-25
Identities = 66/190 (34%), Positives = 108/190 (56%), Gaps = 14/190 (7%)
Query: 369 RLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETD 428
R VVL GP G G + L ++LL + +G +V HTTR R E +G +Y F+++ + + D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 429 VQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKP 488
+ FIE+ E+ N YGTS +V++V A N++C+LDV V++++ + +P I ++P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 489 PSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQ--IMESQYGHLFDKIIIND 546
PS+ L + + R+ + TEE + + +AQ + S+ LFD +IIND
Sbjct: 125 PSLHVLEQR------LRQRNTE------TEESLVKRLAAAQADMESSKEPGLFDVVIIND 172
Query: 547 DLTVAFNELK 556
L A+ ELK
Sbjct: 173 SLDQAYAELK 182
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 103 bits (258), Expect = 3e-22
Identities = 107/489 (21%), Positives = 205/489 (41%), Gaps = 65/489 (13%)
Query: 109 SVHDTVAQKNYDPVLPPMPE-------DIDDEEDSVKIIRLVKNREPLGATIKKDEQTGA 161
SV D + +++ P PP + D + + +++ + K++ LG + G
Sbjct: 1465 SVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHGV 1524
Query: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSK 221
+ A GL+ GD + E + V +K EE+ + + + + K+ +
Sbjct: 1525 FVAEVEDDSPAKGPDGLVP-GDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPE 1583
Query: 222 EETPSKE---GKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDA-------T 271
E T +K +I+AL+D + E LSFKK DIL + DD +
Sbjct: 1584 EFTKAKGLPGDSFYIRALYD-------RLADVEQELSFKKDDILYV---DDTLPQGTFGS 1633
Query: 272 W--WQAKHEADANPRAGLIPSKHFQERRLALR--RPEILVQPLKVSNRKSSGFRKSFRLS 327
W WQ A R G IPSK+ ++ + R E+ ++ R FR
Sbjct: 1634 WMAWQLDENAQKIQR-GQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRK 1692
Query: 328 RKDKKT-NKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-----RLVVLVGPVGVGL 381
K K++ +K + D + + +P +E+ Q +K R V+++GP L
Sbjct: 1693 HKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGP----L 1748
Query: 382 NELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYK 441
++ +++L+++ P +E + S+ E V++ F++Y
Sbjct: 1749 LDVVKEMLVNEAPGKFCRCP-------------LEVMKASQQAIERGVKDCLFVDYKRRS 1795
Query: 442 NNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNA 501
++ T++ S++ + KN+ CLLD+ PH ++ L + P VIFI S + ++E
Sbjct: 1796 GHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKE----- 1850
Query: 502 KIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDK 561
RD T+ +E ++AQ +E +Y F +I L+ ++ ++
Sbjct: 1851 ----QRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQ 1906
Query: 562 LETETHWVP 570
+ + W+P
Sbjct: 1907 EQNKVLWIP 1915
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/74 (33%), Positives = 41/74 (55%), Gaps = 2/74 (2%)
Query: 140 IRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPE 199
+++ K EPLG +I E+ G I V+++ G A ++GL + GD+L E NGI + +
Sbjct: 1351 VKVQKGSEPLGISIVSGEK-GGIYVSKVTVGSIAHQAGLEY-GDQLLEFNGINLRSATEQ 1408
Query: 200 EIIQILAQSQGAIT 213
+ I+ Q IT
Sbjct: 1409 QARLIIGQQCDTIT 1422
Score = 35.0 bits (79), Expect = 0.19
Identities = 15/56 (26%), Positives = 30/56 (53%)
Query: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKII 217
+ A ++ G A + G + VGD + +NGI +++K E +L Q ++T ++
Sbjct: 738 VYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLL 793
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 70.5 bits (171), Expect = 4e-12
Identities = 107/477 (22%), Positives = 186/477 (38%), Gaps = 89/477 (18%)
Query: 116 QKNYDPVLPPMPEDIDDEEDS--VKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAA 173
+ +YD P + ++D S +++R +K + +G + G I V+ + G A
Sbjct: 391 ESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGNDVG-IFVSGVQAGSPA 448
Query: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEE-----TPSKE 228
D G I GD++ +VN +P ++ EE +Q L +++ K++ S+
Sbjct: 449 DGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRV 507
Query: 229 GKMF-IKALFDYNPNEDKAIPCKEAGLSFKKGDILQIM-------SQDDAT---WWQAKH 277
G F I+ F+ P+ +GL F +GD+ ++ Q A W +
Sbjct: 508 GDSFYIRTHFELEPS-------PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRM 560
Query: 278 EADANPR-AGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFR---LSRKDKKT 333
D + G+IP++ E+ +L + V S+ S+ + +R L R KKT
Sbjct: 561 GRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKT 620
Query: 334 NKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVG-VGLNELKRKLLISD 392
+ E S P YE V R+ + K R VV++GPV + + +L ++ D
Sbjct: 621 TQRSRE-DLSALTRQGRYPPYERVV--LREASFK-RPVVILGPVADIAMQKLTAEM--PD 674
Query: 393 TQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSV 452
TV T +K I+ +D+V
Sbjct: 675 QFEIAETVSRTD-------------------------SPSKIIK------------LDTV 697
Query: 453 RSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGA 512
R + K+K LLDV P ++ L +++ P V+F P S L+ R+
Sbjct: 698 RVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQ------------W 745
Query: 513 AKPFTEEDFQEMIKSAQIMESQYGHLFDKII-INDDLTVAFNELKTTFDKLETETHW 568
P + + + AQ + HLF I +N + ELK + +T W
Sbjct: 746 LAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 33.5 bits (75), Expect = 0.55
Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 9/92 (9%)
Query: 121 PVLP-PMPEDIDDEEDSV---KIIRLVKN-REPLGATIK--KDEQTGAIIVARIMRGGAA 173
P+ P P+ + D EE ++ L K+ R G I +D G+++V+ ++ GG A
Sbjct: 8 PIFPAPLDQVADMEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPA 67
Query: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQIL 205
+ G + GD + VNG+ +E+ IQIL
Sbjct: 68 E--GRLQTGDHIVMVNGVSMENATSAFAIQIL 97
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 69.3 bits (168), Expect = 9e-12
Identities = 50/188 (26%), Positives = 84/188 (44%), Gaps = 9/188 (4%)
Query: 368 YRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFET 427
Y +++L GP G EL +L + ++ HTTR E D V+Y FIS+ +F+
Sbjct: 414 YPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDE 473
Query: 428 DVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIK 487
V KFI Y N+ YG + D+V + + ++ V+ L+ F+P I +
Sbjct: 474 MVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVV 533
Query: 488 PPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDD 547
P + E+ + + S + + F IK + + FD++I DD
Sbjct: 534 PMNKEKYEGYLRRKGLFSRAEIE-----FAVSRVDLYIK----INQNFPGYFDEVINADD 584
Query: 548 LTVAFNEL 555
L VA+ +L
Sbjct: 585 LDVAYQKL 592
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 64.3 bits (155), Expect = 3e-10
Identities = 106/467 (22%), Positives = 185/467 (39%), Gaps = 97/467 (20%)
Query: 123 LPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVG 182
L P PED + K++R K + +G + G I VA I G +A++ GL G
Sbjct: 496 LRPSPEDEAIYGPNTKMVRFKKG-DSVGLRLAGGNDVG-IFVAGIQEGTSAEQEGL-QEG 552
Query: 183 DELREVN-----GIPVED------KRPE-EIIQILAQSQGAITFKIIPGSKEETPSKEGK 230
D++ +VN G+ ED + P+ E++ ILAQS+ + I+ + ++
Sbjct: 553 DQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILACGRGDS------ 606
Query: 231 MFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMS---QDDATWWQAKHEADANPRAGL 287
FI++ F+ +K P L+F +G++ +++ W A + + GL
Sbjct: 607 FFIRSHFEC----EKETP---QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNELEK-GL 658
Query: 288 IPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYD 347
IP+K E+ +++ + R ++G R F R + K + D
Sbjct: 659 IPNKSRAEQMASVQNAQ----------RDNAGDRADFWRMRGQRSGVKKNLRKSREDLTA 708
Query: 348 TADV----PTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHT 403
V P YE V R+ K R VVL GP+ ++ + L ++ + T
Sbjct: 709 VVSVSTKFPAYERVL--LREAGFK-RPVVLFGPIA----DIAMEKLANELPDWFQTAKTE 761
Query: 404 TRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCL 463
+ S++S GV +++VR ++ ++K L
Sbjct: 762 PKDAGSEKSTGV-------------------------------VRLNTVRQIIEQDKHAL 790
Query: 464 LDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQE 523
LDV P V L ++ P VIF P S + ++ R+ P + + ++
Sbjct: 791 LDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQR------------LNPTSNKSSRK 838
Query: 524 MIKSAQIMESQYGHLFDKII-INDDLTVAFNELKTTFDKLETETHWV 569
+ A ++ HLF I +N F LK T + E WV
Sbjct: 839 LFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 33.5 bits (75), Expect = 0.55
Identities = 20/83 (24%), Positives = 42/83 (50%), Gaps = 8/83 (9%)
Query: 148 PLGATIKK---DEQTGA-----IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPE 199
P+G + K +E+ G I V + R G A + G +H GD + ++NG E+
Sbjct: 305 PIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLT 364
Query: 200 EIIQILAQSQGAITFKIIPGSKE 222
+ +++ +S+G + ++ S++
Sbjct: 365 DARKLIEKSRGKLQLVVLRDSQQ 387
Score = 31.6 bits (70), Expect = 2.1
Identities = 17/48 (35%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 161 AIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQS 208
+I+++ ++ GG AD GL+ D + VNG P+ED +Q L +S
Sbjct: 63 SIVISDVLPGGPAD--GLLQENDRVVMVNGTPMEDVLHSFAVQQLRKS 108
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 59.3 bits (142), Expect = 9e-09
Identities = 53/193 (27%), Positives = 86/193 (44%), Gaps = 20/193 (10%)
Query: 44 EKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQN--KPLNSEIRELLKLLSK 101
E+ + +++ EKL + P + AL L E N + + + E + + S
Sbjct: 11 ERDICRAIELLEKLQRSGEVPPQKL----QALQRVLQSEFCNAVREVYEHVYETVDISSS 66
Query: 102 PNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKD-EQTG 160
P V+A + TVA + +++ L K E LG I EQ
Sbjct: 67 PEVRANATAKATVAAFA-----------ASEGHSHPRVVELPKTEEGLGFNIMGGKEQNS 115
Query: 161 AIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAI--TFKIIP 218
I ++RI+ GG ADR G + GD+L VNG+ VE + E+ +++L +QG + + P
Sbjct: 116 PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTP 175
Query: 219 GSKEETPSKEGKM 231
EE S+ KM
Sbjct: 176 KVLEEMESRFEKM 188
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 58.9 bits (141), Expect = 1e-08
Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 6/132 (4%)
Query: 128 EDIDDEEDS----VKIIRLVKNREPLGATIKKDEQT-GAIIVARIMRGGAADRSGLIHVG 182
ED DE++S + + L + PLG TI E+ II++ + +GG A+R+G IH+G
Sbjct: 606 EDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIG 665
Query: 183 DELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKA-LFDYNP 241
D + +N ++ K E I +L + +T KI + ++ S K I + L D
Sbjct: 666 DRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGD 725
Query: 242 NEDKAIPCKEAG 253
E+ + P ++ G
Sbjct: 726 VEEDSSPAQKPG 737
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 5/114 (4%)
Query: 94 ELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNR-EPLGAT 152
++L+ L+K S T K D L + I +E ++ L+K LG T
Sbjct: 11 QILRRLTKDESPYTKSASQT---KPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLT 67
Query: 153 IKKD-EQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQIL 205
+ ++ G V+ + +GG A RS + VGD ++ VNGI + R +EII +L
Sbjct: 68 VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLL 121
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 144 KNREPLGATIKKDEQT---GAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEE 200
K+ LG TI ++++ I +G A R+G + +GD+L ++ I +++ E+
Sbjct: 527 KHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMED 586
Query: 201 IIQILAQSQGAITFKIIPGSKEETPSKE 228
+QIL Q + + KI K+E S E
Sbjct: 587 AVQILQQCEDLVKLKI---RKDEDNSDE 611
Score = 40.4 bits (93), Expect = 0.004
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 150 GATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQ 209
G+ + + +++ I A+R G++ +GD + +NGIP ED EE Q+L S
Sbjct: 437 GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDS- 495
Query: 210 GAITFKI 216
+IT K+
Sbjct: 496 -SITSKV 501
Score = 38.9 bits (89), Expect = 0.013
Identities = 18/57 (31%), Positives = 30/57 (52%)
Query: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIP 218
I++ +I ADR G +HVGD + ++G +E E Q LA + + +I+P
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP 334
Score = 33.1 bits (74), Expect = 0.71
Identities = 17/46 (36%), Positives = 24/46 (52%)
Query: 162 IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQ 207
+++ + GG ADR G I GD L V+GI + E + IL Q
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQ 225
>gi|9966877 golgi associated PDZ and coiled-coil motif containing
isoform a [Homo sapiens]
Length = 462
Score = 58.9 bits (141), Expect = 1e-08
Identities = 40/134 (29%), Positives = 71/134 (52%), Gaps = 13/134 (9%)
Query: 97 KLLSKPNVKALLSVHDTV--AQKNYDPVLPPMPEDIDDEEDSVK----------IIRLVK 144
KL ++ + L H TV A + + + PM ++DS+K ++ L +
Sbjct: 235 KLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKE 294
Query: 145 NREPLGATIKKDEQTGA-IIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQ 203
+ E LG +I ++ G I+++ I G ADR G +HVGD + VNG+ + D + +E +
Sbjct: 295 DHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVT 354
Query: 204 ILAQSQGAITFKII 217
IL+Q +G I F+++
Sbjct: 355 ILSQQRGEIEFEVV 368
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,618,382
Number of Sequences: 37866
Number of extensions: 969122
Number of successful extensions: 3492
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 148
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 3021
Number of HSP's gapped (non-prelim): 500
length of query: 576
length of database: 18,247,518
effective HSP length: 108
effective length of query: 468
effective length of database: 14,157,990
effective search space: 6625939320
effective search space used: 6625939320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.