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Search of human proteins with 167614488
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
(808 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 1633 0.0
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 575 e-164
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 398 e-110
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 146 7e-35
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 146 7e-35
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 146 7e-35
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 142 9e-34
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 142 9e-34
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 139 1e-32
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 138 2e-32
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 135 2e-31
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 129 1e-29
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 127 4e-29
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 127 4e-29
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 122 2e-27
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 122 2e-27
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 122 2e-27
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 121 2e-27
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 120 5e-27
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 120 7e-27
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 118 2e-26
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 110 4e-24
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 108 3e-23
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 107 4e-23
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 107 4e-23
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 107 4e-23
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 107 6e-23
gi|183583567 TBC1 domain family, member 3E [Homo sapiens] 107 6e-23
gi|183583563 TBC1 domain family, member 3D [Homo sapiens] 106 8e-23
gi|90577185 TBC1 domain family member 3C [Homo sapiens] 105 2e-22
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 1633 bits (4228), Expect = 0.0
Identities = 808/808 (100%), Positives = 808/808 (100%)
Query: 1 METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARP 60
METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARP
Sbjct: 1 METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARP 60
Query: 61 AWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGV 120
AWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGV
Sbjct: 61 AWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGV 120
Query: 121 ETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVA 180
ETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVA
Sbjct: 121 ETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVA 180
Query: 181 SGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPA 240
SGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPA
Sbjct: 181 SGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPA 240
Query: 241 ENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLA 300
ENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLA
Sbjct: 241 ENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLA 300
Query: 301 LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKG 360
LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKG
Sbjct: 301 LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKG 360
Query: 361 IPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAAR 420
IPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAAR
Sbjct: 361 IPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAAR 420
Query: 421 GGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYY 480
GGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYY
Sbjct: 421 GGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYY 480
Query: 481 SAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRV 540
SAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRV
Sbjct: 481 SAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRV 540
Query: 541 WDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEV 600
WDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEV
Sbjct: 541 WDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEV 600
Query: 601 TNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLL 660
TNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLL
Sbjct: 601 TNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLL 660
Query: 661 SLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKE 720
SLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKE
Sbjct: 661 SLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKE 720
Query: 721 TRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLS 780
TRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLS
Sbjct: 721 TRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLS 780
Query: 781 LRRKADGPPGPHDGGDRPSAEARQDAYF 808
LRRKADGPPGPHDGGDRPSAEARQDAYF
Sbjct: 781 LRRKADGPPGPHDGGDRPSAEARQDAYF 808
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 575 bits (1483), Expect = e-164
Identities = 290/507 (57%), Positives = 361/507 (71%), Gaps = 28/507 (5%)
Query: 255 GISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQ 314
G +GPR A SL G + D++SS+GSDSE NG A R+ DK+GF+ GSQ
Sbjct: 6 GENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQ 65
Query: 315 YSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLS 374
+ +P++V RQRE KWLDM +NWDKW++++ +K++LRC+KGIP SLR +AWQYLS
Sbjct: 66 GAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLS 125
Query: 375 NSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKA 434
K L+QNPGKF+EL+ +PGDPKWLDVIE+DLHRQFPFHEMF +RGGHGQQDL+R+LKA
Sbjct: 126 GGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKA 185
Query: 435 YTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIF 494
YT+YRP+EGYCQAQAP+AAVLLMHMPAEQAFWCLVQIC+KYLPGYYS LEAIQLDGEI
Sbjct: 186 YTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEIL 245
Query: 495 FALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFR 554
F+LL++ SP+AH+HL RQ+IDP+LYMTEWFMC F+RTLPW+SVLRVWDMFFCEGVKIIFR
Sbjct: 246 FSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFR 305
Query: 555 VALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIEREN 614
V LVLL+H LGS EK+++CQG YET+E+LR+L + MQE FLV EV LPVTE IERE+
Sbjct: 306 VGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREH 365
Query: 615 AAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSL-----LSLPGLKSRG 669
QL++W+ETRGELQ R RLHG++AI + +P L PS S+ LPG K++
Sbjct: 366 LIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAK- 424
Query: 670 SRAAGGAPSPPPPVRR-----------ASAGPAPGP--VVTAEG-LHPSLPSPTGNSTPL 715
P PP ++ PAP VV A G P P +S P
Sbjct: 425 -------PKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPK 477
Query: 716 GSS-KETRKQEKERQKQEKERQKQEKE 741
S+ ++ Q + ++ QE E
Sbjct: 478 DSAPQDLAPQVSAHHRSQESLTSQESE 504
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 398 bits (1023), Expect = e-110
Identities = 186/366 (50%), Positives = 265/366 (72%), Gaps = 2/366 (0%)
Query: 283 LADDVSSMGSDSEINGLA-LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSN 341
L DD SS+GSDSE++G R+ D+YGF+GGS P D+ RQRE+KW++M S+
Sbjct: 15 LQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPG-PGHPPADLIRQREMKWVEMTSH 73
Query: 342 WDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLD 401
W+K +SRR++KVK++CRKGIPS+LRA+ W L + + +PG ++EL APGDP+W++
Sbjct: 74 WEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWME 133
Query: 402 VIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPA 461
I +DLHRQFP HEMF + GHGQQ L ++LKAYT+YRP++GYCQAQ PVAAVLLMH+P
Sbjct: 134 TIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPP 193
Query: 462 EQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMT 521
E+AFWCLVQIC+ YLPGYY +EA++LD E+F ALLRR P H+HL++ + P+LY+
Sbjct: 194 EEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLP 253
Query: 522 EWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETME 581
EWF+C+FAR+LP+ +VLRVWD F EG +++FRV L L+R LG+ E+ +C G+ ET+
Sbjct: 254 EWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLG 313
Query: 582 QLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRA 641
LR +P +QE+ + +V ++ ++E ++RE AQL + ++ RP RL G++A
Sbjct: 314 ALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQA 373
Query: 642 IHEERR 647
I E ++
Sbjct: 374 IFEAQQ 379
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 146 bits (369), Expect = 7e-35
Identities = 112/401 (27%), Positives = 189/401 (47%), Gaps = 26/401 (6%)
Query: 234 TPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSD 293
+P P +SQ+ S + P S +PD L L + + LE+ + + SM
Sbjct: 3 SPTLSPDSSSQEALSAPTCSP-TSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGS 61
Query: 294 SEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKV 353
+G +L S S SS + + W + + W++W R+ + +
Sbjct: 62 RRNSGSSL-------------VSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLL 108
Query: 354 KLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPF 413
K RKGIP RA WQ L ++ ++ +N ++ EL + + L I +D+ R +P
Sbjct: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKN--QYSELLKMSSPCEKL--IRRDIARTYPE 164
Query: 414 HEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD 473
HE F + GQ+ L+ ++KAY++ + GYCQ A + +LLM MP E+AF V++
Sbjct: 165 HEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQ 224
Query: 474 KY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTL 532
+Y L + + + L F +L+ P + H R Q +Y + WF+ +F T
Sbjct: 225 EYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTF 284
Query: 533 PWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQ--- 589
P RV+D+F EG++I+FRV L LL+ + +L +GM + + R +P Q
Sbjct: 285 PLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQL-DMEGMSQYFQ--RVIPHQFDS 341
Query: 590 CMQEDFL-VHEVTNLPVTEALIERENAAQLKKWRETRGELQ 629
C + L ++V P +E+E AA K E + E++
Sbjct: 342 CPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIK 382
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 146 bits (369), Expect = 7e-35
Identities = 112/401 (27%), Positives = 189/401 (47%), Gaps = 26/401 (6%)
Query: 234 TPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSD 293
+P P +SQ+ S + P S +PD L L + + LE+ + + SM
Sbjct: 3 SPTLSPDSSSQEALSAPTCSP-TSDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGS 61
Query: 294 SEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKV 353
+G +L S S SS + + W + + W++W R+ + +
Sbjct: 62 RRNSGSSL-------------VSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLL 108
Query: 354 KLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPF 413
K RKGIP RA WQ L ++ ++ +N ++ EL + + L I +D+ R +P
Sbjct: 109 KELIRKGIPHHFRAIVWQLLCSATDMPVKN--QYSELLKMSSPCEKL--IRRDIARTYPE 164
Query: 414 HEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD 473
HE F + GQ+ L+ ++KAY++ + GYCQ A + +LLM MP E+AF V++
Sbjct: 165 HEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQ 224
Query: 474 KY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTL 532
+Y L + + + L F +L+ P + H R Q +Y + WF+ +F T
Sbjct: 225 EYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTF 284
Query: 533 PWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQ--- 589
P RV+D+F EG++I+FRV L LL+ + +L +GM + + R +P Q
Sbjct: 285 PLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQL-DMEGMSQYFQ--RVIPHQFDS 341
Query: 590 CMQEDFL-VHEVTNLPVTEALIERENAAQLKKWRETRGELQ 629
C + L ++V P +E+E AA K E + E++
Sbjct: 342 CPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIK 382
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 146 bits (369), Expect = 7e-35
Identities = 81/229 (35%), Positives = 117/229 (51%), Gaps = 6/229 (2%)
Query: 335 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELE-RA 393
W ++ W L R + + + G+P +LRA+ WQ L+ + N +
Sbjct: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHD----NQAMLDRYRILI 568
Query: 394 PGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAA 453
D VI +D+HR FP H+ F GG GQ+ LY+I KAY++Y D GYCQ Q+ +AA
Sbjct: 569 TKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAA 628
Query: 454 VLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQ 512
VLL+HMP EQAF LV+I Y L Y E + L++ P H H
Sbjct: 629 VLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDL 688
Query: 513 RIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLR 561
++ +Y ++WF+ +F P V + D+ CEG+ IIF VAL LL+
Sbjct: 689 NLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 142 bits (359), Expect = 9e-34
Identities = 124/457 (27%), Positives = 201/457 (43%), Gaps = 52/457 (11%)
Query: 299 LALRKTDKYGFLGGSQ---YSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKL 355
L + TD++GFL + ++ ++E +++ +R KWL M W+K+ + +K
Sbjct: 40 LVYKVTDRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKY--KNTEKFHR 95
Query: 356 RCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELE-RAPGDPKWLDVIEKDLHRQFPFH 414
R KGIP LR + W L ++ E+ + +L+ RA G + I+ D++R F H
Sbjct: 96 RIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDH 155
Query: 415 EMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD- 473
MF R G QQ L+ +L AY+IY + GYCQ + + A+LLM+M E AFW LV++
Sbjct: 156 IMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSG 215
Query: 474 --KYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFART 531
+ G++ G + E +L + +HL Q I Y +WF F
Sbjct: 216 PKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDR 275
Query: 532 LPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCM 591
P+ LR+WD++ EG +++ ++ +L KL M +ME+L Q+ +
Sbjct: 276 TPFTLNLRIWDIYIFEGERVLTAMSYTIL--------KLHKKHLMKLSMEELVEFFQETL 327
Query: 592 QEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQP 651
+DF + + + + I + K G+ P + L Q P
Sbjct: 328 AKDFFFED--DFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPL-----------GQLP 374
Query: 652 PLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGN 711
P S + L S G R+ G PSP RR S P H P P
Sbjct: 375 PELQSWGVHHL----SNGQRSV-GRPSPLASGRRESGAP--------HRRHEHSPHPQSR 421
Query: 712 S-TPLGSSKETRKQEKERQKQEKERQKQEKEREKERQ 747
+ TP R Q R+ E+E +K + E + +R+
Sbjct: 422 TGTP------ERAQPPRRKSVEEESKKLKDEADFQRK 452
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 142 bits (359), Expect = 9e-34
Identities = 124/457 (27%), Positives = 201/457 (43%), Gaps = 52/457 (11%)
Query: 299 LALRKTDKYGFLGGSQ---YSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKL 355
L + TD++GFL + ++ ++E +++ +R KWL M W+K+ + +K
Sbjct: 57 LVYKVTDRFGFLHEEELPDHNVAVERQKHLEI--ERTTKWLKMLKGWEKY--KNTEKFHR 112
Query: 356 RCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELE-RAPGDPKWLDVIEKDLHRQFPFH 414
R KGIP LR + W L ++ E+ + +L+ RA G + I+ D++R F H
Sbjct: 113 RIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDH 172
Query: 415 EMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICD- 473
MF R G QQ L+ +L AY+IY + GYCQ + + A+LLM+M E AFW LV++
Sbjct: 173 IMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSG 232
Query: 474 --KYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFART 531
+ G++ G + E +L + +HL Q I Y +WF F
Sbjct: 233 PKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDR 292
Query: 532 LPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCM 591
P+ LR+WD++ EG +++ ++ +L KL M +ME+L Q+ +
Sbjct: 293 TPFTLNLRIWDIYIFEGERVLTAMSYTIL--------KLHKKHLMKLSMEELVEFFQETL 344
Query: 592 QEDFLVHEVTNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQP 651
+DF + + + + I + K G+ P + L Q P
Sbjct: 345 AKDFFFED--DFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPL-----------GQLP 391
Query: 652 PLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGN 711
P S + L S G R+ G PSP RR S P H P P
Sbjct: 392 PELQSWGVHHL----SNGQRSV-GRPSPLASGRRESGAP--------HRRHEHSPHPQSR 438
Query: 712 S-TPLGSSKETRKQEKERQKQEKERQKQEKEREKERQ 747
+ TP R Q R+ E+E +K + E + +R+
Sbjct: 439 TGTP------ERAQPPRRKSVEEESKKLKDEADFQRK 469
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 139 bits (350), Expect = 1e-32
Identities = 90/265 (33%), Positives = 133/265 (50%), Gaps = 10/265 (3%)
Query: 303 KTDKYGFLGGSQYSGSLE----SSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCR 358
+ D YGF + + SS V + R R +KW + SR VK R
Sbjct: 11 RIDPYGFERPEDFDDAAYEKFFSSYLVTLTR-RAIKWSRLLQGGGVPRSRT---VKRYVR 66
Query: 359 KGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFA 418
KG+P RA+ W LS ++ ++QNPG + +L + +P+ D I DL+R FP + F
Sbjct: 67 KGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKFR 126
Query: 419 ARGGHG-QQDLYRILKAYTIYRPDEGYCQAQAPVAAVL-LMHMPAEQAFWCLVQICDKYL 476
Q+ LY +L AY + GYCQ +A L L+ E++FW L + + L
Sbjct: 127 KTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRIL 186
Query: 477 PGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWAS 536
P YYS + ++ D E+ L+R P + R + L ++ WF+C+F LP +
Sbjct: 187 PDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVET 246
Query: 537 VLRVWDMFFCEGVKIIFRVALVLLR 561
VLR+WD F EG KIIFRVAL L++
Sbjct: 247 VLRIWDCLFNEGSKIIFRVALTLIK 271
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 138 bits (347), Expect = 2e-32
Identities = 79/231 (34%), Positives = 124/231 (53%), Gaps = 10/231 (4%)
Query: 335 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLS---NSKELLEQNPGKFEELE 391
W ++ S W L+ R +++ R G+P +LR + WQ L+ N+ L+E+ + +
Sbjct: 541 WGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKY--RILITK 598
Query: 392 RAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPV 451
+P D I +D++R FP H+ F GG GQ LY+I KAY++Y + GYCQ Q+ +
Sbjct: 599 ESPQD----SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFL 654
Query: 452 AAVLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLR 510
AAVLL+HMP EQAF LV+I Y L + E + L++ P + H
Sbjct: 655 AAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFL 714
Query: 511 RQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLR 561
++ +Y ++WF+ +F P V + D+ CEG+ +IF VAL LL+
Sbjct: 715 DISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLK 765
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 135 bits (340), Expect = 2e-31
Identities = 99/332 (29%), Positives = 163/332 (49%), Gaps = 20/332 (6%)
Query: 331 RELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEE 389
+E W F+ + + + R +K + KGIP S+R + W LS + +PG +E+
Sbjct: 485 KEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYED 544
Query: 390 L-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQA 447
L E++ G + IE+DLHR P H F + G L R+L AY P+ GYCQA
Sbjct: 545 LVEKSMGKYNLATEEIERDLHRSLPEHPAF--QNEMGIAALRRVLTAYAFRNPNIGYCQA 602
Query: 448 QAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHR 507
V +VLL++ E+AFW LV +C++ LP YY+ + +D +F L R P +
Sbjct: 603 MNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYD 662
Query: 508 HLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSV 567
++ + + ++ WF+ +F +P+ S + V D FF EG+K+IF++AL +L +V
Sbjct: 663 CMQDLGVISTISLS-WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLD---ANV 718
Query: 568 EKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNL---------PVTEALIERENAAQL 618
+KL +C+ E M L +D + + +L P E I R
Sbjct: 719 DKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTSY 778
Query: 619 KKWRETRGEL--QYRPSRRLHGSRAIHEERRR 648
+K+ R +L Q R +RL + + + +R
Sbjct: 779 EKFGTIRADLIEQMRFKQRLKVIQTLEDTTKR 810
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 129 bits (323), Expect = 1e-29
Identities = 96/343 (27%), Positives = 163/343 (47%), Gaps = 23/343 (6%)
Query: 248 STSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKY 307
ST +L P S P +PD L L + + LE+ D S+ S +NG
Sbjct: 66 STPALSP--SSPSQLSPDDLELLAKLEEQNRLLET---DSKSLRS---VNGSRRNS---- 113
Query: 308 GFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRA 367
G S S S SS + + W + + W+ ++ ++VK KGIP RA
Sbjct: 114 ---GSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRA 170
Query: 368 KAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQD 427
WQ L +++ + ++ ++ EL + + L I +D+ R +P H F + GQ+
Sbjct: 171 IVWQLLCSAQSMPIKD--QYSELLKMTSPCEKL--IRRDIARTYPEHNFFKEKDSLGQEV 226
Query: 428 LYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEA 486
L+ ++KAY++ + GYCQ A + +LLM MP E+AF V++ Y L + +
Sbjct: 227 LFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAE 286
Query: 487 IQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFC 546
+ L F +++ P H + Q +Y + WF+ IF T P R++D+F
Sbjct: 287 LGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMS 346
Query: 547 EGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQ 589
EG++I+FRV L LL+ + +L +GM + +++ +P Q
Sbjct: 347 EGLEIVFRVGLALLQMNQAELMQL-DMEGMLQHFQKV--IPHQ 386
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 127 bits (319), Expect = 4e-29
Identities = 84/258 (32%), Positives = 130/258 (50%), Gaps = 9/258 (3%)
Query: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
+ +E W F + + + R K + KGIP SLR + W S + + +PG +
Sbjct: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
Query: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
EL E++ G + IE+DLHR P H F + G L R+L AY P GYC
Sbjct: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAF--QNELGIAALRRVLTAYAFRNPTIGYC 593
Query: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLA 505
QA V +VLL++ E+AFW LV +C++ LP YY+ + +D IF L R P
Sbjct: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
Query: 506 HRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLG 565
++ + + ++ WF+ +F +P+ S + + D FF EG+K+I +VAL +L
Sbjct: 654 SEKMQDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLD---A 709
Query: 566 SVEKLRSCQGMYETMEQL 583
++E+L C E M L
Sbjct: 710 NMEQLLGCSDEGEAMTML 727
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 127 bits (319), Expect = 4e-29
Identities = 84/258 (32%), Positives = 130/258 (50%), Gaps = 9/258 (3%)
Query: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
+ +E W F + + + R K + KGIP SLR + W S + + +PG +
Sbjct: 476 KMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYY 535
Query: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
EL E++ G + IE+DLHR P H F + G L R+L AY P GYC
Sbjct: 536 AELVEKSTGKYSLATEEIERDLHRSMPEHPAF--QNELGIAALRRVLTAYAFRNPTIGYC 593
Query: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLA 505
QA V +VLL++ E+AFW LV +C++ LP YY+ + +D IF L R P
Sbjct: 594 QAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQL 653
Query: 506 HRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLG 565
++ + + ++ WF+ +F +P+ S + + D FF EG+K+I +VAL +L
Sbjct: 654 SEKMQDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLD---A 709
Query: 566 SVEKLRSCQGMYETMEQL 583
++E+L C E M L
Sbjct: 710 NMEQLLGCSDEGEAMTML 727
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 122 bits (305), Expect = 2e-27
Identities = 79/269 (29%), Positives = 132/269 (49%), Gaps = 9/269 (3%)
Query: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
+ +E W +F+ + +S R +K + +GIP +LR + W S + + NP +
Sbjct: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
Query: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
E+ E++ G + IE+DL R P H F + G L R+L AY P GYC
Sbjct: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYC 572
Query: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLA 505
QA + +VLL++ E+AFW LV +C++ LP Y++ + +D +F L+R P
Sbjct: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
Query: 506 HRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLG 565
H+ + ++ WF+ +F LP S + V D FF +G+K I ++ L +L + L
Sbjct: 633 TEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNL- 690
Query: 566 SVEKLRSCQGMYETMEQLRNLPQQCMQED 594
+KL +C+ E + L +D
Sbjct: 691 --DKLLTCKDDAEAVTALNRFFDNVTNKD 717
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 122 bits (305), Expect = 2e-27
Identities = 75/256 (29%), Positives = 126/256 (49%), Gaps = 14/256 (5%)
Query: 333 LKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQY-LSNSKELLEQN--PGKFEE 389
+KW + F++ ++K R GIP R+K W++ + + N PG F+
Sbjct: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
Query: 390 L------ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEG 443
L ++ P + IE DL R P ++ ++ G Q L +L A++ PD G
Sbjct: 695 LLQKALEKQNPASKQ----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIG 750
Query: 444 YCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRAS 502
YCQ + AV L+++ E AFWCLV I + ++P YY+ L Q+D +F L+
Sbjct: 751 YCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKL 810
Query: 503 PLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 562
P H H + ++D L WF+ +F ++ + ++WD F EG K+IFR AL L ++
Sbjct: 811 PRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKY 870
Query: 563 TLGSVEKLRSCQGMYE 578
+ KL+ +++
Sbjct: 871 KEEEILKLQDSMSIFK 886
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 122 bits (305), Expect = 2e-27
Identities = 75/256 (29%), Positives = 126/256 (49%), Gaps = 14/256 (5%)
Query: 333 LKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQY-LSNSKELLEQN--PGKFEE 389
+KW + F++ ++K R GIP R+K W++ + + N PG F+
Sbjct: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
Query: 390 L------ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEG 443
L ++ P + IE DL R P ++ ++ G Q L +L A++ PD G
Sbjct: 695 LLQKALEKQNPASKQ----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIG 750
Query: 444 YCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRAS 502
YCQ + AV L+++ E AFWCLV I + ++P YY+ L Q+D +F L+
Sbjct: 751 YCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKL 810
Query: 503 PLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 562
P H H + ++D L WF+ +F ++ + ++WD F EG K+IFR AL L ++
Sbjct: 811 PRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKY 870
Query: 563 TLGSVEKLRSCQGMYE 578
+ KL+ +++
Sbjct: 871 KEEEILKLQDSMSIFK 886
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 121 bits (304), Expect = 2e-27
Identities = 93/345 (26%), Positives = 156/345 (45%), Gaps = 24/345 (6%)
Query: 305 DKYGFL----GGSQYSGSLESSIPVDVARQRELKW---LDMFSN-------WDKWLSR-- 348
D++GF G + SL ++ P+ + L+W L+ N WDK
Sbjct: 43 DEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLP 102
Query: 349 RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDV--IEKD 406
R +K++ GIP +R + W LS + + + + E+ + + + + IEKD
Sbjct: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162
Query: 407 LHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFW 466
L R P + FA+ G G L R+L+A P+ GYCQ VAA LL+ + E AFW
Sbjct: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222
Query: 467 CLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFM 525
+ I + LP Y+S L +Q D + L+ + P + L+ I+ L WF+
Sbjct: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282
Query: 526 CIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRN 585
FA + +LR+WD+FF EG +++F++ L +L E+L + L +
Sbjct: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHL---KEEELIQSENSASIFNTLSD 339
Query: 586 LPQQCMQEDFLVHEVTNL--PVTEALIERENAAQLKKWRETRGEL 628
+P Q + L+ L +T+ +E + L +G+L
Sbjct: 340 IPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQL 384
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 120 bits (301), Expect = 5e-27
Identities = 89/297 (29%), Positives = 143/297 (48%), Gaps = 36/297 (12%)
Query: 337 DMFSNWDKWLSRRFQKVKLRC---------RKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
++ WDK L + K+RC ++G+P S R + WQ+L+ L + P K
Sbjct: 888 EVLITWDKKLLNC--RAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNK- 944
Query: 388 EELERAPGDPKWLDVIEK----------DLHRQFPFHEMFAARGGHGQQDLYRILKAYTI 437
+ P D + +++++ DL R FP H F+ + G GQ L+ +LKAY++
Sbjct: 945 ----QQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSL 1000
Query: 438 YRPDEGYCQAQAPVAAVLLMHMPAEQAFWCL-VQICDKYLPGYYSAGLEAIQLDGEIFFA 496
+ GYCQ + VA VLL+HM EQAF L + D Y + ++Q+
Sbjct: 1001 LDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSR 1060
Query: 497 LLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVA 556
LL + HL I P LY WF+ +FA V RV+D+ F +G ++IF+VA
Sbjct: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVA 1120
Query: 557 LVLL--RHTLGSVEKLRSCQGMYETMEQLRN-LPQQCMQE-DFLVHEVTNLPVTEAL 609
L LL + TL + C+ +E L+N LP E + ++ +V + +++ L
Sbjct: 1121 LSLLSSQETL-----IMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQL 1172
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 120 bits (300), Expect = 7e-27
Identities = 81/238 (34%), Positives = 117/238 (49%), Gaps = 24/238 (10%)
Query: 342 WDKWLSRRFQ-KVKLRCRK-------GIPSSLRAKAWQYLSNSKELLEQNPGKFEELERA 393
W+K LS + K+K K G+P R + W++L+ L Q P K +
Sbjct: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSK-----QQ 828
Query: 394 PGDPKWLDVIEK----------DLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEG 443
P D + +++++ DL R FP H F+A+ G GQ LY ILKAY++ + G
Sbjct: 829 PKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG 888
Query: 444 YCQAQAPVAAVLLMHMPAEQAFWCL-VQICDKYLPGYYSAGLEAIQLDGEIFFALLRRAS 502
YCQ + VA +LL+HM E+AF L + D L Y + +Q+ LL
Sbjct: 889 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH 948
Query: 503 PLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLL 560
+ HL I P LY WF+ +FA P V RV+DM F +G ++IF+VAL LL
Sbjct: 949 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL 1006
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 118 bits (296), Expect = 2e-26
Identities = 77/250 (30%), Positives = 125/250 (50%), Gaps = 6/250 (2%)
Query: 314 QYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQY 372
Q SGS + + + W D F + + + R +K++ GIP SLR + W
Sbjct: 458 QQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLL 517
Query: 373 LSNSKELLEQNPGKFEEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYR 430
S++ L +PG + L E + G + + IE+DLHR P H F G L R
Sbjct: 518 FSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAA--LRR 575
Query: 431 ILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLD 490
+L AY P GYCQ+ + +VLL++ E+AFW LV +C++ LP Y++ + Q+D
Sbjct: 576 VLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVD 635
Query: 491 GEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVK 550
+F L++ P H+ + ++ WF+ +F +P S + V D FF +G+K
Sbjct: 636 QSVFEELIKGHLPELAEHMNDLSALASVSLS-WFLTLFLSIMPLESAVNVVDCFFYDGIK 694
Query: 551 IIFRVALVLL 560
IF++ L +L
Sbjct: 695 AIFQLGLAVL 704
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 110 bits (276), Expect = 4e-24
Identities = 112/383 (29%), Positives = 173/383 (45%), Gaps = 34/383 (8%)
Query: 281 ESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGS---LESSIPVDVARQRELKWLD 337
E+L + SDS I + K D+YGFL Y L + I +R L L+
Sbjct: 538 EALQWEAGEASSDS-IELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLE 596
Query: 338 MFSNWDKWLSRRFQ---------KVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFE 388
D+ L R+ ++K R G+P R + W++L + + PG ++
Sbjct: 597 AV---DRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQ 653
Query: 389 EL---ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
EL +A P IE DL+R FP ++ F L R+L A++ P GYC
Sbjct: 654 ELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYC 712
Query: 446 QAQAPVAAVLLMHMPAEQ-AFWCLVQICDKYLPG-YYSAGLEAIQLDGEIFFALLRRASP 503
Q +AA+ L+ + E+ AFWCLV I + +P YY L A Q+D + LL P
Sbjct: 713 QGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLP 772
Query: 504 LAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHT 563
HL + +D L WF+ +FA +L +LRVWD F EG K + ++ L++
Sbjct: 773 RLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEK-EILRLQNG 831
Query: 564 LGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIEREN-AAQLKKWR 622
L + LR +L N+ M F + ++ L ++ RE A+L++
Sbjct: 832 LEIYQYLRFFTKTISNSRKLMNIAFNDM-NPFRMKQLRQL----RMVHRERLEAELRELE 886
Query: 623 ETRGE-LQYRPSRRLHGSRAIHE 644
+ + E L+ R SRR RA+ E
Sbjct: 887 QLKAEYLERRASRR----RAVSE 905
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 108 bits (269), Expect = 3e-23
Identities = 99/398 (24%), Positives = 168/398 (42%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N++E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKKG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 107 bits (267), Expect = 4e-23
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKQG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 107 bits (267), Expect = 4e-23
Identities = 89/354 (25%), Positives = 162/354 (45%), Gaps = 32/354 (9%)
Query: 320 ESSIPVDVARQ---------RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAW 370
E+ +P AR+ R KW++M W+ + + K+ R KGIP ++R W
Sbjct: 53 ETELPPVTAREAKKIRREMTRTSKWMEMLGEWETY--KHSSKLIDRVYKGIPMNIRGPVW 110
Query: 371 QYLSNSKELLEQNPGKFEEL-ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLY 429
L N +E+ +NPG+++ + ER + + I+ D+ H F R G Q++L+
Sbjct: 111 SVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELF 170
Query: 430 RILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEA 486
IL AY+ Y P+ GYC+ + + A+ L+++P E AFW LVQ+ LPG++S
Sbjct: 171 YILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGT 230
Query: 487 IQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASV---LRVWDM 543
+Q + ++ ++ P H Q + + C+ + S+ LR+WD+
Sbjct: 231 VQGLQDQQEHVVPKSQPKTMWH---QDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDV 287
Query: 544 FFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRN--LPQQCMQEDFLVHEVT 601
+ EG +++ + + L+ + K C G++ +LRN M +D + +
Sbjct: 288 YLVEGEQVLMPITSIALKVQQKRLMKTSRC-GLW---ARLRNQFFDTWAMNDDTV---LK 340
Query: 602 NLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGP 655
+L + + R+ + +G L RP G + + + R Q P GP
Sbjct: 341 HLRASTKKLTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYR--QAPPGP 392
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 107 bits (267), Expect = 4e-23
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKQG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 107 bits (266), Expect = 6e-23
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKKG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|183583567 TBC1 domain family, member 3E [Homo sapiens]
Length = 549
Score = 107 bits (266), Expect = 6e-23
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKKG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|183583563 TBC1 domain family, member 3D [Homo sapiens]
Length = 549
Score = 106 bits (265), Expect = 8e-23
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 36/398 (9%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQLDGEIFFALLRRASPLAH 506
+AA+ L+++P E AFW LVQ+ L G++S +Q + ++ + P
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTM 251
Query: 507 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS 566
H ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKR 311
Query: 567 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG 626
+ K C F V E + + A +KK +G
Sbjct: 312 LTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRKQG 355
Query: 627 EL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPPVR 684
+L +P + SR + R + G + PG +R R A P P
Sbjct: 356 DLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP-- 410
Query: 685 RASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 -RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
>gi|90577185 TBC1 domain family member 3C [Homo sapiens]
Length = 549
Score = 105 bits (261), Expect = 2e-22
Identities = 99/400 (24%), Positives = 168/400 (42%), Gaps = 40/400 (10%)
Query: 331 RELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEEL 390
R+ KW+DM +W+K+ S R K+ R KG+P ++R W L N +E+ +NPG+++ +
Sbjct: 74 RKSKWVDMLGDWEKYKSSR--KLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIM 131
Query: 391 -ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQA 449
E+ + + I++D+ H F R G Q++L IL AY Y P+ GYC+ +
Sbjct: 132 KEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLS 191
Query: 450 PVAAVLLMHMPAEQAFWCLVQICDK---YLPGYYSAGLEAIQ--LDGEIFFALLRRASPL 504
+AA+ L+++P E AFW LVQ+ L G++S +Q D + ++ +
Sbjct: 192 HIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQSKTM 251
Query: 505 AHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTL 564
H+ ++ + + I + LR+WD++ EG + + + + +
Sbjct: 252 GHQD--KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQ 309
Query: 565 GSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRET 624
+ K C F V E + + A +KK
Sbjct: 310 KRLTKTSRCGPWAR----------------FCNRFVDTWARDEDTVLKHLRASMKKLTRK 353
Query: 625 RGEL--QYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPP 682
+G+L +P + SR + R + G + PG +R R A P P
Sbjct: 354 QGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQ---APPGPPARFPRPIWSASPPRAP 410
Query: 683 VRRASAGPAPGPVVTAEGLHP----SLPSPT-GNSTPLGS 717
S+ P PG V E +P +PSP P GS
Sbjct: 411 ---RSSTPCPGGAV-REDTYPVGTQGVPSPALAQGGPQGS 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,683,034
Number of Sequences: 37866
Number of extensions: 2859100
Number of successful extensions: 105346
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1609
Number of HSP's successfully gapped in prelim test: 2714
Number of HSP's that attempted gapping in prelim test: 28371
Number of HSP's gapped (non-prelim): 41917
length of query: 808
length of database: 18,247,518
effective HSP length: 110
effective length of query: 698
effective length of database: 14,082,258
effective search space: 9829416084
effective search space used: 9829416084
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.