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Search of human proteins with 110735441
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
(1224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 2631 0.0
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 1462 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 745 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 684 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 639 0.0
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 635 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 567 e-161
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 565 e-160
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 529 e-150
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 525 e-149
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 512 e-145
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 511 e-144
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 469 e-132
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 466 e-131
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 459 e-129
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 444 e-124
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 397 e-110
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 397 e-110
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 392 e-109
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 372 e-102
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 371 e-102
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 352 2e-96
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 335 1e-91
gi|145309328 papilin [Homo sapiens] 328 3e-89
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 307 5e-83
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 282 1e-75
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 279 1e-74
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 272 1e-72
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 238 3e-62
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 238 3e-62
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 2631 bits (6819), Expect = 0.0
Identities = 1224/1224 (100%), Positives = 1224/1224 (100%)
Query: 1 MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY 60
MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY
Sbjct: 1 MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY 60
Query: 61 DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA 120
DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA
Sbjct: 61 DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA 120
Query: 121 PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL 180
PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
Sbjct: 121 PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL 180
Query: 181 RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL 240
RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL
Sbjct: 181 RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL 240
Query: 241 GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK 300
GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK
Sbjct: 241 GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK 300
Query: 301 KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH 360
KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
Sbjct: 301 KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH 360
Query: 361 TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN 420
TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN
Sbjct: 361 TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN 420
Query: 421 EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH 480
EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH
Sbjct: 421 EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH 480
Query: 481 KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA 540
KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA
Sbjct: 481 KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA 540
Query: 541 LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR 600
LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR
Sbjct: 541 LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR 600
Query: 601 TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF 660
TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF
Sbjct: 601 TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF 660
Query: 661 RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV 720
RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV
Sbjct: 661 RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV 720
Query: 721 GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN 780
GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN
Sbjct: 721 GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN 780
Query: 781 VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV 840
VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV
Sbjct: 781 VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV 840
Query: 841 ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL 900
ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL
Sbjct: 841 ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL 900
Query: 901 KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY 960
KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY
Sbjct: 901 KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY 960
Query: 961 DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA 1020
DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA
Sbjct: 961 DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA 1020
Query: 1021 RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE 1080
RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE
Sbjct: 1021 RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE 1080
Query: 1081 KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA 1140
KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA
Sbjct: 1081 KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA 1140
Query: 1141 SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV 1200
SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV
Sbjct: 1141 SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV 1200
Query: 1201 PQHGMCSHKFYGKQCCKTCSKSNL 1224
PQHGMCSHKFYGKQCCKTCSKSNL
Sbjct: 1201 PQHGMCSHKFYGKQCCKTCSKSNL 1224
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 1462 bits (3785), Expect = 0.0
Identities = 690/1238 (55%), Positives = 866/1238 (69%), Gaps = 63/1238 (5%)
Query: 9 RGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEV 68
RGLA L + + CA AA A S S +Y V+ EV
Sbjct: 20 RGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGL----------NDDYVFVTPVEV 69
Query: 69 DHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTL 128
D G Y+SH+I+H+ R++R+ + SLH R + H++L+ S+ +++ FIVQ L
Sbjct: 70 DSAGSYISHDILHNGRKKRSAQNAR-SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVL 127
Query: 129 GKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLS 188
GK G Q P CFYQG +R+ +SSVA+STC GLSG+IRT + ++ + PLP L+
Sbjct: 128 GKDGASETQK-PEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLA 186
Query: 189 WKLGRAAQGSSPSHVLYKRSTEP---------------------HAPGASEVLVTSRTWE 227
+ ++ HVLYKR+ E H P AS+ SR E
Sbjct: 187 QEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQ----SRETE 242
Query: 228 LAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRN 287
H+ L QKQHFCGRRKKY P+PP ED ++ DEY S R +RS +S +
Sbjct: 243 YHHRRL----------QKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKG 292
Query: 288 EELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLED 347
LNVETLVV DKKM++ HG N+TTY+LT++NMVS LFKDGTIG +IN+ +V LILLE
Sbjct: 293 --LNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQ 350
Query: 348 EQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPI 407
E GL+I+HHAD +L+SFCQWQS L+GK+G RHDHAILLTG DICSWKNEPCDTLGFAPI
Sbjct: 351 EPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPI 410
Query: 408 SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNG 467
SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN C+K+EGNIMSPTL G NG
Sbjct: 411 SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNG 470
Query: 468 VFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAK 527
VFSWS CSRQYL KFLST QA CL D+PK +YKYP+KLPG++YDA+TQCKWQFG KAK
Sbjct: 471 VFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAK 530
Query: 528 LCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHG 587
LC L F KDICK+LWCHR+G +CETKFMPAAEGT+CG MWCR GQCVK+G+ GP+P HG
Sbjct: 531 LCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHG 590
Query: 588 HWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDF 647
WS WS WS CSRTCGGGV + R C NPKP +GG FC GS+R +LCN C +S+DF
Sbjct: 591 QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
Query: 648 RAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSED 707
RA QCAE+NS+ FRG Y+WKPYT+VE++D CKLYC AE F+FFF++S KVKDGTPCS +
Sbjct: 651 RAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPN 710
Query: 708 SRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTI 767
+VCIDG+CE VGCD+ LGS AV D CGVC G+NS C ++GLY H N+YY +V I
Sbjct: 711 KNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLI 770
Query: 768 PSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPEN 827
P+GARSI I E+ VS+SY++VR+ ++YYL G W++DWPG + F+GTTF+Y+RS+N PE
Sbjct: 771 PAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPER 830
Query: 828 LIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA--QPSYTWAIVRSECSVSC 885
L A GPTNETL+ E+L QG+NPG+AW+Y++P++ PPA +P+YTW+IV+SECSVSC
Sbjct: 831 LYAPGPTNETLVFEILMQGKNPGIAWKYALPKV-MNGTPPATKRPAYTWSIVQSECSVSC 889
Query: 886 GGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGG 945
GGG + V+ C RD QVN SFC+ KT+PVT C +CP W G WS CS+ C G
Sbjct: 890 GGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAG 949
Query: 946 GAQSRPVQCTRRVHYD-SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGK 1004
G QSR +QC ++ + E V SLCP P+ QACNS +CPP WS GPW++CS TCG+
Sbjct: 950 GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGR 1009
Query: 1005 GWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCS 1064
G RKR + CK + A+ LP++ CTS P+P + E C+L RC K +LQW+ S+WS+CS
Sbjct: 1010 GVRKRELLCK----GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECS 1065
Query: 1065 VTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAG 1124
TC G +KR +KC+EK GK ++C ++ KP+L+LE C CP HP +
Sbjct: 1066 ATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMV- 1124
Query: 1125 PSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAE 1184
W++ PW QCT +CGGGVQTRSV C+ GRP+S CLLHQKP ACNT+FCP E
Sbjct: 1125 ---AGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPE 1181
Query: 1185 KK-DAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
K+ D C D+F+WC+LVPQHG+C+HKFYGKQCCK+C++
Sbjct: 1182 KREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTR 1219
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 745 bits (1923), Expect = 0.0
Identities = 410/1085 (37%), Positives = 587/1085 (54%), Gaps = 107/1085 (9%)
Query: 60 YDLVSAYEVDHRGDYVSHEIMH--HQRRRRAV----PVSEVESLHLRLKGSRHDFHMDLR 113
Y L VD G ++S + + H RRRR++ P V L +L FH++L
Sbjct: 42 YQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLT 101
Query: 114 TSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSS-VALSTCQGLSGMIR 172
++ V+ F V+ GK G + D C Y G L+ R+++ VALS C GL G+I
Sbjct: 102 LNTDFVSKHFTVEYWGKDGPQWKHDFL--DNCHYTGYLQDQRSTTKVALSNCVGLHGVIA 159
Query: 173 TEEADYFLRPLPS------HLSWKLGRAAQGSSPSHVLYKRST--------EPHAPGASE 218
TE+ +YF+ PL + H S++ G HV+YK+S H G S+
Sbjct: 160 TEDEEYFIEPLKNTTEDSKHFSYENGHP-------HVIYKKSALQQRHLYDHSHC-GVSD 211
Query: 219 VLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHK 278
+ + W L S L + H R K
Sbjct: 212 FTRSGKPWWLNDTSTVSYSLPINNTHIHH----------------------------RQK 243
Query: 279 RSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIA 338
RS+ + E VETLVV DK M+ HG ++I Y+L+++N+V+ L++D ++G +NI
Sbjct: 244 RSV-----SIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNII 298
Query: 339 IVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMG--KDGT--------RHDHAILLTG 388
+ LI+L ++QP L I+HHAD +L SFC+WQ ++ DG HD+A+L+T
Sbjct: 299 VARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITR 358
Query: 389 LDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN 448
DIC++KN+PC TLG A ++GMC RSC+INED GLG AFTIAHE GHNFGM HDG GN
Sbjct: 359 YDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGN 418
Query: 449 MCKKS---EGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPE 505
C +M+ + FSWS CSR Y+ FL + + CL ++P P +++ YP
Sbjct: 419 SCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEP-PKRDFLYPA 477
Query: 506 KLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICG- 564
PG++YDA+ QC++Q+G ++ C ++C+ LWC +C T +PAAEGT+C
Sbjct: 478 VAPGQVYDADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQT 534
Query: 565 ---HDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
WC G CV +G P+ G W WS W CSRTCGGGVS R C +P PS G
Sbjct: 535 GNIEKGWCYQGDCVPFGT-WPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGG 593
Query: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
GK+C G + + CN+ CP S DFR QCA+ ++ FRG++Y WKPYT + C L
Sbjct: 594 GKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CAL 652
Query: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
C+AEG++F+ + V DGT C+ DS ++CI+G C+ VGCDN+LGSDA ED C VC G+
Sbjct: 653 NCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGD 712
Query: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
S C G + Y +V IP G+ I + E+ +S +YI++++ YY+NG W
Sbjct: 713 GSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAW 772
Query: 802 TVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMP--R 859
T+DWP ++ +GT F Y+R +EPE+L A GPT+E LIV +L Q +N G+ +++++P R
Sbjct: 773 TIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITR 832
Query: 860 LGTEKQPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYR-DLKFQVNMSFCNPKTRPVT 917
G+ + +TW SECS +C GG C R D V ++C+P ++P
Sbjct: 833 TGSGDN---EVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPE 889
Query: 918 GLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRV-HYDSEPVPASLCPQPAPS 976
C CPP W +G+W CS+TC GG ++R V C R++ + E + S C P
Sbjct: 890 NQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPV 949
Query: 977 SRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKP 1036
++ CN+QSCPP W A W+EC+ CG G++ R V CKS++ S + P A C E KP
Sbjct: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLS---KTFPAAQCPEESKP 1006
Query: 1037 RMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCS 1096
+ C L RC P+ W+ W QCS C G Q R ++C Y AS C
Sbjct: 1007 PVRIRCSLGRCPPPR---WVTGDWGQCSAQCGLGQQMRTVQCL------SYTGQASSDCL 1057
Query: 1097 HLPKP 1101
+P
Sbjct: 1058 ETVRP 1062
Score = 50.4 bits (119), Expect = 1e-05
Identities = 35/120 (29%), Positives = 47/120 (39%), Gaps = 7/120 (5%)
Query: 866 PPAQPSYTWAIVRSECSVSCGGGQMTVREGCYR-DLKFQVNMSFCNPKTRPVTGLVPCKV 924
PP + W SEC+ CG G C DL + C +++P + C +
Sbjct: 960 PPQWVALDW----SECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR-IRCSL 1014
Query: 925 SACPPS-WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNS 983
CPP W G+W CS CG G Q R VQC S ++ P C+S
Sbjct: 1015 GRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDS 1074
Score = 40.4 bits (93), Expect = 0.010
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 11/61 (18%)
Query: 1129 SWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLH--------QKPSASLACNTHFC 1180
+W PWS+C+A+C GGVQ + V C R ++ + P ACNT C
Sbjct: 843 TWNHQPWSECSATCAGGVQRQEVVC---KRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
Query: 1181 P 1181
P
Sbjct: 900 P 900
Score = 38.1 bits (87), Expect = 0.052
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG--CLLHQKPSASLACNTHFCPIAEK 1185
G W S W +C+ +CGGGV + C + G CL +K S CNT CP+ +
Sbjct: 562 GPW--SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRS--CNTDPCPLGSR 617
Query: 1186 --KDAFCKDY 1193
++ C D+
Sbjct: 618 DFREKQCADF 627
Score = 32.7 bits (73), Expect = 2.2
Identities = 31/108 (28%), Positives = 42/108 (38%), Gaps = 22/108 (20%)
Query: 1058 SAWSQCSVTCERGTQKRFLKCAE-------KYVSGKYRELASKKCSHLPKPSLEL-ERAC 1109
S W +CS TC G C KY G+ + S P S + E+ C
Sbjct: 565 SLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQC 624
Query: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGG 1157
A + PF RG ++ W T GGGV+ ++ CLA G
Sbjct: 625 ADFD---NMPF------RGKYYN--WKPYT---GGGVKPCALNCLAEG 658
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 684 bits (1766), Expect = 0.0
Identities = 396/1080 (36%), Positives = 570/1080 (52%), Gaps = 82/1080 (7%)
Query: 60 YDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLV 119
Y++ VDH G ++ +R+RR + L ++ F ++L SS L+
Sbjct: 39 YEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLL 98
Query: 120 APGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSS-VALSTCQGLSGMIRTEEADY 178
A V+ + G + P C Y G L+ ++S VA+STC GL G+I +E +Y
Sbjct: 99 AGHVSVEYWTREGLAWQRAARPH--CLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEY 156
Query: 179 FLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDL 238
+ PL H K R+ + S P HV+YKRS+ L H L D
Sbjct: 157 LIEPL--HGGPKGSRSPEESGP-HVVYKRSS------------------LRHPHL---DT 192
Query: 239 RLGLPQKQHFCGRR--KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLV 296
G+ ++ + GR + + PP L + + L KRS+ R E VETLV
Sbjct: 193 ACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGL--KRSVSR-----ERYVETLV 245
Query: 297 VVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISH 356
V DK M+ HG ++ YVL I+N+V+ LF+D ++G +NI + LILL ++QP L I+H
Sbjct: 246 VADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITH 305
Query: 357 HADHTLSSFCQWQSGLMGKDG----------TRHDHAILLTGLDICSWKNEPCDTLGFAP 406
HA +L SFC+WQ ++ G HD A+L+T DIC +KN+PC TLG AP
Sbjct: 306 HAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAP 365
Query: 407 ISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCK---KSEGNIMSPTLA 463
+ GMC + RSC++NED GL AFTIAHE GH FGM HDG GN C + +M+ +
Sbjct: 366 VGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHIT 425
Query: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
+ F WS CSR Y+ FL + +CL ++P P +++ YP PG+ YDA+ QC++Q G
Sbjct: 426 MKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP-PRQDFVYPTVAPGQAYDADEQCRFQHG 484
Query: 524 EKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICG-HDM---WCRGGQCVKYGD 579
K++ C ++C LWC +C T +PAAEGT+C H + WC CV +G
Sbjct: 485 VKSRQCKYG---EVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGS 541
Query: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
P+ G W W+ W CSRTCGGGVS SR C +P+P+ GGK+C G R + CN+
Sbjct: 542 R-PEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD 600
Query: 640 CPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVK 699
CP S DFR QC+E +S FRG+ YKWK Y + C L C+AEGF+F+ + V
Sbjct: 601 CPPGSQDFREVQCSEFDSIPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTERAAAVV 659
Query: 700 DGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTN 759
DGTPC D+ ++C+ G C+ VGCD VLGSD ED C VC G+ SAC G+++
Sbjct: 660 DGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGA 719
Query: 760 QYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYR 819
Y +V IP G+ I I ++N+S S+++++ L G P R +GTTF R
Sbjct: 720 GYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLR 779
Query: 820 RSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVR- 878
+ ++ ++L A GP N +LIV +L + P + + ++ P + + PP Y+W
Sbjct: 780 QGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAP-IARDSLPP----YSWHYAPW 834
Query: 879 SECSVSCGGGQMTVREGCYRDL-KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWS 937
++CS C GG C L V +C+ ++ C CPP W VGNWS
Sbjct: 835 TKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWS 894
Query: 938 ACSRTCGGGAQSRPVQCTRRVH-YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWA 996
CSR+C G +SR V C RRV + + + S CPQP P +AC+ +CPP W+A W+
Sbjct: 895 LCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWS 954
Query: 997 ECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWL 1056
EC+ +CG G R R V CKS + A LP A C+ KP C L+RC +W+
Sbjct: 955 ECTPSCGPGLRHRVVLCKSADHRA---TLPPAHCSPAAKPPATMRCNLRRC---PPARWV 1008
Query: 1057 VSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP--SLELERAC-APLP 1113
W +CS C G ++R ++C + AS +C+ +P + + E C +P P
Sbjct: 1009 AGEWGECSAQCGVGQRQRSVRCT------SHTGQASHECTEALRPPTTQQCEAKCDSPTP 1062
Score = 97.1 bits (240), Expect = 9e-20
Identities = 61/205 (29%), Positives = 91/205 (44%), Gaps = 28/205 (13%)
Query: 985 SCPP-AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPK-PRMHEAC 1042
S PP +W PW +CS C G + +AV C++ S+ + C++ K P+ AC
Sbjct: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSA---VAPHYCSAHSKLPKRQRAC 879
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
+ C W+V WS CS +C+ G + R + C + + + + L C P+P
Sbjct: 880 NTEPCPP----DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSAC---PQPR 932
Query: 1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGR---- 1158
+ AC CP W A WS+CT SCG G++ R V C +
Sbjct: 933 PPVLEACHGPTCPPE------------WAALDWSECTPSCGPGLRHRVVLCKSADHRATL 980
Query: 1159 PASGCLLHQKPSASLACNTHFCPIA 1183
P + C KP A++ CN CP A
Sbjct: 981 PPAHCSPAAKPPATMRCNLRRCPPA 1005
Score = 47.8 bits (112), Expect = 7e-05
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 13/77 (16%)
Query: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL----AGGRPASGCLL 1165
AP+ PP+ SW +PW++C+A C GG Q ++V+C + C
Sbjct: 817 APIARDSLPPY--------SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSA 868
Query: 1166 HQK-PSASLACNTHFCP 1181
H K P ACNT CP
Sbjct: 869 HSKLPKRQRACNTEPCP 885
Score = 40.0 bits (92), Expect = 0.014
Identities = 28/79 (35%), Positives = 35/79 (44%), Gaps = 12/79 (15%)
Query: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG--- 1162
+R C P A GP W +PW C+ +CGGGV + S C RP G
Sbjct: 533 KRVCVPFGSRPEGVDGAWGP----W--TPWGDCSRTCGGGVSSSSRHC-DSPRPTIGGKY 585
Query: 1163 CLLHQKPSASLACNTHFCP 1181
CL ++ S CNT CP
Sbjct: 586 CLGERRRHRS--CNTDDCP 602
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 639 bits (1649), Expect = 0.0
Identities = 379/1034 (36%), Positives = 529/1034 (51%), Gaps = 76/1034 (7%)
Query: 34 AAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSE 93
A APG+P P P G + D+V VD G ++S+E+ R+R V V
Sbjct: 23 ALAPGAPG---PAPGRATEG---RAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRR 76
Query: 94 VESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRS 153
L+ + +L + L+APGF+ +T + G C G ++
Sbjct: 77 DAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQD 136
Query: 154 HR--NSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEP 211
A+S C GL G+ + DYF+ PL S A G + HV+YKR
Sbjct: 137 PELEGGLAAISACDGLKGVFQLSNEDYFIEPLDS------APARPGHAQPHVVYKRQAPE 190
Query: 212 HAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEY 271
+ S + L S R Q+Q + R + +
Sbjct: 191 RLAQRGDSSAPSTCGVQVYPELESRRERW--EQRQQWRRPRLRRL--------------- 233
Query: 272 KSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTI 331
H+RS+ ++E VETLVV D KM++ HG + +YVLTI+NMV+ LF D +I
Sbjct: 234 -----HQRSV-----SKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSI 283
Query: 332 GGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGT---RHDHAILLTG 388
G I+I IV L+LLEDE+ L I+HHAD+TL SFC+WQ + K HD AILLT
Sbjct: 284 GNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTR 343
Query: 389 LDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN 448
D+C+ N PC+TLG + ++GMC +RSC+INEDTGL LAFT+AHE GH+FG+ HDG GN
Sbjct: 344 KDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGN 403
Query: 449 MCKK--SEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK 506
C+ IMSP L +WS CSRQY+ +FL +CL D P +P
Sbjct: 404 DCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCL-DDPPAKDIIDFPSV 462
Query: 507 LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHD 566
PG LYD + QC+ Q+G + C + ++C LWC +G C +K A +GT CG +
Sbjct: 463 PPGVLYDVSHQCRLQYGAYSAFC--EDMDNVCHTLWC-SVGTTCHSKLDAAVDGTRCGEN 519
Query: 567 MWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCE 626
WC G+CV G P+ G WS WS+WS CSR+CG GV R CT P P + G++C
Sbjct: 520 KWCLSGECVPVGFR-PEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCV 578
Query: 627 GSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAE 686
G + +LCN Q CP FR QC+ ++ ++G+ + W P V D + C+L+C
Sbjct: 579 GERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQLHTWVPV--VNDVNPCELHCRPA 636
Query: 687 GFDFFFSLSNKVKDGTPCSE--DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSA 744
F L + V DGTPC + SR++CI+GIC+ VGCD + S A+ED CGVC+GN S
Sbjct: 637 NEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGST 696
Query: 745 CTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNA-LRRYYLNGHWTV 803
C G + + Y + IP+GAR IRI E+ + +++++R+ +Y+LNG WT+
Sbjct: 697 CHTVSGTFEEAEGLG-YVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTI 755
Query: 804 DWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRL--G 861
W G Y+ +GTTF Y R N ENL + GPT E + ++LLFQ NPGV +EY++ R G
Sbjct: 756 QWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGG 814
Query: 862 TEKQPPAQPSYTWAI-VRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV 920
++ PP P ++W ++C+V+CG G C V+ C+P RP
Sbjct: 815 HDEVPP--PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQR 872
Query: 921 PCKVSACPPSWSVGNWSACSRTCG-GGAQSRPVQCTRRVHYDSEPV--PASLCPQPAPSS 977
C CP W G W CS +CG GG R V C R V D + P + P P +
Sbjct: 873 KCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPT 932
Query: 978 RQACNSQ-SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKP 1036
CN CP W+ G W++CS TCG+G ++R V C TN + C +P
Sbjct: 933 ETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC--TNDTG-------VPCDEAQQP 983
Query: 1037 RMHEACLLQRCHKP 1050
C L C P
Sbjct: 984 ASEVTCSLPLCRWP 997
Score = 141 bits (356), Expect = 3e-33
Identities = 102/325 (31%), Positives = 134/325 (41%), Gaps = 59/325 (18%)
Query: 911 PKTRPVTGLVPCKVSACPPS---------WSVGNWSACSRTCGGGAQSRPVQCTRRVHYD 961
P+T+P L P A PP+ W GNWS CS TCG GA RPV+C+ D
Sbjct: 1389 PETQP---LAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDED 1445
Query: 962 SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSAR 1021
P PQPA + C+ + C W +G W++CS +CG G R V C T
Sbjct: 1446 CAPAGR---PQPA----RRCHLRPCA-TWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLR- 1496
Query: 1022 AQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEK 1081
L P KP H C Q C L W S+W +CS C G Q+R + C E
Sbjct: 1497 -PLRPFHCQPGPAKPPAHRPCGAQPC-----LSWYTSSWRECSEACGGGEQQRLVTCPEP 1550
Query: 1082 YVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTAS 1141
+ C +P+ R C PC + W PW QC+
Sbjct: 1551 GL-----------CEEALRPNTT--RPCNTHPCTQ-------------WVVGPWGQCSGP 1584
Query: 1142 CGGGVQTRSVQCL--AGGRP---ASGCLLHQKPSASLACNTHFC-PIAEKKDAFCKDYFH 1195
CGGGVQ R V+C+ G P + C P +S C T C P+ + + F
Sbjct: 1585 CGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPPRCERDRLSFG 1644
Query: 1196 WCYLVPQHGMCSHKFYGKQCCKTCS 1220
+C + G C QCC++CS
Sbjct: 1645 FCETLRLLGRCQLPTIRTQCCRSCS 1669
Score = 113 bits (283), Expect = 1e-24
Identities = 89/267 (33%), Positives = 108/267 (40%), Gaps = 42/267 (15%)
Query: 863 EKQPPAQPSYT----WAIVR-SECSVSCGGGQM--TVREGCYRDLKFQVNMSFCNPKTRP 915
E PPA P W SECS +CG G + VR RD C P RP
Sbjct: 1400 EAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRD-------EDCAPAGRP 1452
Query: 916 VTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPA 974
C + C +W GNWS CSR+CGGG+ R VQC D P+ C P PA
Sbjct: 1453 QPAR-RCHLRPCA-TWHSGNWSKCSRSCGGGSSVRDVQCVDT--RDLRPLRPFHCQPGPA 1508
Query: 975 -PSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSE 1033
P + + C +Q C +W W ECS CG G ++R V C +C
Sbjct: 1509 KPPAHRPCGAQPC-LSWYTSSWRECSEACGGGEQQRLVTCPE-----------PGLCEEA 1556
Query: 1034 PKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASK 1093
+P C C QW+V W QCS C G Q+R +KC E S
Sbjct: 1557 LRPNTTRPCNTHPC-----TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTG--LPEEDSD 1609
Query: 1094 KCSHLPKPSLELERACAPLPC-PRHPP 1119
+C H P E R C C P PP
Sbjct: 1610 QCGHEAWP--ESSRPCGTEDCEPVEPP 1634
Score = 102 bits (255), Expect = 2e-21
Identities = 63/157 (40%), Positives = 77/157 (49%), Gaps = 13/157 (8%)
Query: 928 PP--SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPAPSSRQA-CNS 983
PP SW G W+ C+ TCG G Q + V C R + PV C P P +Q C+
Sbjct: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER---QAGPVDEEHCDPLGRPDDQQRKCSE 876
Query: 984 QSCPPAWSAGPWAECSHTCGKGW-RKRAVAC-KSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
Q CP W AG W CS +CG G +RAV C +S ++ L P A C P+P
Sbjct: 877 QPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPA-CEHLPRPPTETP 935
Query: 1042 CLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKC 1078
C H P W V WSQCSVTC GTQ+R + C
Sbjct: 936 C---NRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLC 969
Score = 89.7 bits (221), Expect = 1e-17
Identities = 60/209 (28%), Positives = 91/209 (43%), Gaps = 30/209 (14%)
Query: 978 RQACNSQSCPP---AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEP 1034
R+A PP +W GPW +C+ TCG+G +++ V C +A + + C
Sbjct: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLER----QAGPVDEEHCDPLG 865
Query: 1035 KPRMHEACLLQRC-HKPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELAS 1092
+P + ++C +P +W W CS +C G +R + C + L
Sbjct: 866 RPDDQQ----RKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEP 921
Query: 1093 KKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQ 1152
C HLP+P E PC RH P A +W WSQC+ +CG G Q R+V
Sbjct: 922 PACEHLPRPPTET-------PCNRHVPCPA------TWAVGNWSQCSVTCGEGTQRRNVL 968
Query: 1153 CLAG-GRPASGCLLHQKPSASLACNTHFC 1180
C G P C Q+P++ + C+ C
Sbjct: 969 CTNDTGVP---CDEAQQPASEVTCSLPLC 994
Score = 37.7 bits (86), Expect = 0.068
Identities = 21/50 (42%), Positives = 26/50 (52%), Gaps = 8/50 (16%)
Query: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKC 640
SSW CS CGGG + RL T P+P CE + R T + CN+ C
Sbjct: 1527 SSWRECSEACGGG--EQQRLVTCPEPG----LCEEALRPNTTRPCNTHPC 1570
Score = 33.5 bits (75), Expect = 1.3
Identities = 19/55 (34%), Positives = 22/55 (40%), Gaps = 1/55 (1%)
Query: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
G W S WS C+ SCG GVQ+ QC G + CN CP
Sbjct: 539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACP 593
Score = 32.0 bits (71), Expect = 3.7
Identities = 12/24 (50%), Positives = 16/24 (66%)
Query: 594 SWSPCSRTCGGGVSHRSRLCTNPK 617
+WS CSR+CGGG S R C + +
Sbjct: 1470 NWSKCSRSCGGGSSVRDVQCVDTR 1493
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 635 bits (1638), Expect = 0.0
Identities = 377/1033 (36%), Positives = 540/1033 (52%), Gaps = 82/1033 (7%)
Query: 43 PRPPP---PAERPGWMEKG--EYDLVSAYEVDHRGDYVSHEIMH---HQRRRRAVPVSEV 94
P+P P P R KG EY +V VD G ++S+ + + RR+R + SE
Sbjct: 30 PQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSE- 88
Query: 95 ESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSL--R 152
+ ++ R+ D +L + ++ +I++ + C G++ +
Sbjct: 89 DWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQ 148
Query: 153 SHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPH 212
R + ALS C GL+G + D+F+ P+ H +G H++Y+R P
Sbjct: 149 GTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKH------PLVEGGYHPHIVYRRQKVPE 202
Query: 213 APGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYK 272
+P + + QKQ R+K+ + LP
Sbjct: 203 TK----------------EPTCGLKDSVNISQKQELW--REKW-------ERHNLPS--- 234
Query: 273 SCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIG 332
RSL R ++E VETLVV D KM++ HG EN+ +Y+LTI+NMV+ LF + +IG
Sbjct: 235 ------RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIG 288
Query: 333 GNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGK---DGTRHDHAILLTGL 389
I+I +V LILLE+E+ GL I HHA+ TLSSFC+WQ + K + HD A+LLT
Sbjct: 289 NAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRK 348
Query: 390 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNM 449
DIC+ N PC+TLG + +SGMC +RSC INED+GL LAFTIAHE GH+FG+ HDG+ N
Sbjct: 349 DICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND 408
Query: 450 CKK--SEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKL 507
C+ IMS L +WS CS +Y+ +FL CL D PK K K
Sbjct: 409 CEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKK-KGLKSKVIA 467
Query: 508 PGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDM 567
PG +YD + QC+ Q+G A C +++C+ LWC G C +K AA+GT CG
Sbjct: 468 PGVIYDVHHQCQLQYGPNATFC--QEVENVCQTLWCSVKG-FCRSKLDAAADGTQCGEKK 524
Query: 568 WCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEG 627
WC G+C+ G + P+ G W WS WS CSRTCG GV RLC NP+P GGK+C G
Sbjct: 525 WCMAGKCITVGKK-PESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
Query: 628 STRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEG 687
+ +LCN C ++ FR QC+E ++ ++ Y W P C+LYC
Sbjct: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCRPID 641
Query: 688 FDFFFSLSNKVKDGTPCSE--DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSAC 745
F + + V DGTPC E +SRNVCI+GIC+ VGCD + S+A ED CGVC G+ S+C
Sbjct: 642 GQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSC 701
Query: 746 TIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNA-LRRYYLNGHWTVD 804
R ++ K + Y + IP GAR IR+ E+ + +++++R+ +YYLNG + +
Sbjct: 702 QTVRKMF-KQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQ 760
Query: 805 WPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEK 864
W G YK +GT F Y R + E L+ATGPTNE++ ++LLFQ NPG+ +EY++ + G +
Sbjct: 761 WNGNYKLAGTVFQYDRK-GDLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDN 819
Query: 865 QPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCK 923
Q Y W +ECSV+CG G C + + V +FC+P+T+P C
Sbjct: 820 D-VEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCH 878
Query: 924 VSACPPSWSVGNWSACSRTCG-GGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQAC 981
ACPP W G W ACS TCG G + R V C + + D + +P + C P + +C
Sbjct: 879 EKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC 938
Query: 982 NSQ-SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
N CP W+ G W+ECS +CG G R R+V C + D C KP
Sbjct: 939 NRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH---------DEPCDVTRKPNSRA 989
Query: 1041 ACLLQRCHKPKKL 1053
C LQ+C +++
Sbjct: 990 LCGLQQCPSSRRV 1002
Score = 112 bits (280), Expect = 2e-24
Identities = 83/307 (27%), Positives = 119/307 (38%), Gaps = 60/307 (19%)
Query: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAW 990
W VGNWS CS TCG GA R V+C+ ++ D + +P P+ R C+ + C W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAI-----QRPDPAKR--CHLRPC-AGW 1368
Query: 991 SAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKP 1050
G W++CS C G++ R + C + + P P L C+
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPP------LSMSCNPE 1422
Query: 1051 KKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACA 1110
W V WSQCS +C G Q+R + C R ++ C+ E C
Sbjct: 1423 PCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCN---------EHLCC 1473
Query: 1111 PLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG-------- 1162
W W C+ SCGGG Q R+VQC+ P+ G
Sbjct: 1474 ------------------HWATGNWDLCSTSCGGGFQKRTVQCV----PSEGNKTEDQDQ 1511
Query: 1163 CLLHQKPSAS--LACNTHFCPIAEKKDAFC-KDYF--HWCYLVPQHGMCSHKFYGKQCCK 1217
CL KP CN C + D C KD +C + CS +CC
Sbjct: 1512 CLCDHKPRPPEFKKCNQQAC--KKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCF 1569
Query: 1218 TCSKSNL 1224
+C ++++
Sbjct: 1570 SCPQTHI 1576
Score = 107 bits (268), Expect = 5e-23
Identities = 69/224 (30%), Positives = 90/224 (40%), Gaps = 27/224 (12%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
SECS +CG G R C + S C RP C + C W VGNWS
Sbjct: 1323 SECSTTCGLGAYWRRVECSTQMD-----SDCAAIQRPDPAK-RCHLRPCA-GWKVGNWSK 1375
Query: 939 CSRTCGGGAQSRPVQCT-RRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAE 997
CSR C GG + R +QC R H + P P +CN + C AW PW++
Sbjct: 1376 CSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC-EAWQVEPWSQ 1434
Query: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
CS +CG G ++R V C P +C +P +C C W
Sbjct: 1435 CSRSCGGGVQERGVFC------------PGGLCDWTKRPTSTMSCNEHLC-----CHWAT 1477
Query: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP 1101
W CS +C G QKR ++C K + C H P+P
Sbjct: 1478 GNWDLCSTSCGGGFQKRTVQCVPS-EGNKTEDQDQCLCDHKPRP 1520
Score = 90.9 bits (224), Expect = 7e-18
Identities = 59/198 (29%), Positives = 83/198 (41%), Gaps = 26/198 (13%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH- 1048
W G W ECS TCG G R++ C ++ C E +P + ++CH
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRG----MVKATFCDPETQPNGRQ----KKCHE 879
Query: 1049 KPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
K +W W CS TC G +KR + C + VS + + L C HL KP L
Sbjct: 880 KACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDE-QALPPTDCQHLLKPKTLLS- 937
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
+ CP W WS+C+ SCGGGV+ RSV C C + +
Sbjct: 938 CNRDILCP------------SDWTVGNWSECSVSCGGGVRIRSVTC--AKNHDEPCDVTR 983
Query: 1168 KPSASLACNTHFCPIAEK 1185
KP++ C CP + +
Sbjct: 984 KPNSRALCGLQQCPSSRR 1001
Score = 66.2 bits (160), Expect = 2e-10
Identities = 42/120 (35%), Positives = 53/120 (44%), Gaps = 12/120 (10%)
Query: 869 QPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSAC 927
+P W + S+CS SCGGG C L C+ RP T + C C
Sbjct: 1422 EPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRP-TSTMSCNEHLC 1472
Query: 928 PPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSC 986
W+ GNW CS +CGGG Q R VQC +E LC +P P + CN Q+C
Sbjct: 1473 C-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 39.7 bits (91), Expect = 0.018
Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 26/103 (25%)
Query: 560 GTICGHDMWCRGGQCVKYGDEGPKPTHG---------HWSDWSSWSPCSRTCGGGVSHRS 610
G + ++C GG C D +PT HW+ +W CS +CGGG R+
Sbjct: 1441 GGVQERGVFCPGGLC----DWTKRPTSTMSCNEHLCCHWAT-GNWDLCSTSCGGGFQKRT 1495
Query: 611 RLCTNPKPSHGGK-------FCEGSTR--TLKLCNSQKCPRDS 644
C PS G K C+ R K CN Q C + +
Sbjct: 1496 VQCV---PSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
Score = 37.7 bits (86), Expect = 0.068
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 2/57 (3%)
Query: 1124 GPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFC 1180
G W WS+C+ +CG G R V+C + S C Q+P + C+ C
Sbjct: 1311 GHGSAHWIVGNWSECSTTCGLGAYWRRVEC--STQMDSDCAAIQRPDPAKRCHLRPC 1365
Score = 35.8 bits (81), Expect = 0.26
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 12/89 (13%)
Query: 595 WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKCPRDSVDFRAAQC 652
WS CSR+CGGGV R C G C+ + R + CN C + C
Sbjct: 1432 WSQCSRSCGGGVQERGVFCP-------GGLCDWTKRPTSTMSCNEHLCCHWATG-NWDLC 1483
Query: 653 AEHNSRRFRGRHYKWKPY--TQVEDQDLC 679
+ F+ R + P + EDQD C
Sbjct: 1484 STSCGGGFQKRTVQCVPSEGNKTEDQDQC 1512
Score = 34.3 bits (77), Expect = 0.75
Identities = 18/53 (33%), Positives = 22/53 (41%), Gaps = 2/53 (3%)
Query: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFC 1180
G W SPWS C+ +CG GVQ+ C G + CN H C
Sbjct: 546 GRW--SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPC 596
Score = 30.8 bits (68), Expect = 8.3
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 8/54 (14%)
Query: 594 SWSPCSRTCGGGVSHRSRLCT------NPKPSHGGKFCEGSTRTLKL-CNSQKC 640
+WS CSR C GG R C N +P H +F G L + CN + C
Sbjct: 1372 NWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH-CQFLAGIPPPLSMSCNPEPC 1424
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 567 bits (1461), Expect = e-161
Identities = 363/1147 (31%), Positives = 559/1147 (48%), Gaps = 105/1147 (9%)
Query: 59 EYDLVSAYEVDHRGDYVSHEIMHHQRRRRAV--------------PVSEVESLHLRLKGS 104
EY++VS V+ G+ + H +R RR++ S H RL
Sbjct: 47 EYEIVSPIRVNALGEPFPTNV-HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAF 105
Query: 105 RHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPED----FCFYQGSLRSHRNSSVA 160
F +L ++ +AP F V LG G + E+ CFY+G + ++ +
Sbjct: 106 GQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAV 165
Query: 161 LSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVL 220
+S C G+ G R+ + DYF+ PL S + + + H++Y+RS P
Sbjct: 166 ISLCSGMLGTFRSHDGDYFIEPLQSMDEQE---DEEEQNKPHIIYRRSAPQREPSTGRHA 222
Query: 221 VTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSC------ 274
+ H+ HS D + +K G R + + + + +
Sbjct: 223 CDTSE----HKNRHSKDKKKTRARKW---GERINLAGDVAALNSGLATEAFSAYGNKTDN 275
Query: 275 LRHKRSLLRSHR--NEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIG 332
R KR+ R+ R + VE LVV D +M+ HG EN+ Y+LT++++V++++KD +IG
Sbjct: 276 TREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIG 334
Query: 333 GNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDIC 392
INI IV LI++ +EQ G IS +A TL +FCQWQ G HD A+LLT DIC
Sbjct: 335 NLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDIC 394
Query: 393 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCK- 451
++ CDTLG A + +C YRSC+I+ED+GL AFTIAHE GH F M HD + N CK
Sbjct: 395 R-AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKE 452
Query: 452 ---KSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLP 508
KS ++M+PTL + WS CSR+Y+ +FL T CL ++P+ + Y P +LP
Sbjct: 453 EGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPES-RPYPLPVQLP 511
Query: 509 GELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIG---RKCETKFMPAAEGTICGH 565
G LY+ N QC+ FG +++C + C+ LWC+ + + C T+ P A+GT C
Sbjct: 512 GILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEP 568
Query: 566 DMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFC 625
C+ G CV + P T G W WS + CSRTCGGG+ R C P+P +GGK+C
Sbjct: 569 GKHCKYGFCVPKEMDVPV-TDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYC 627
Query: 626 EGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGR----HYKWKP-YTQVEDQDLCK 680
G K CN++ C + DFR QCA + + F + +W P Y+ + +D CK
Sbjct: 628 VGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCK 687
Query: 681 LYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNG 740
L+C G ++ L ++V DGTPC +D+ ++C+ G+C + GCD+VL S A D CGVC G
Sbjct: 688 LFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGG 747
Query: 741 NNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVS-----TSYISVRNALRRY 795
+NS+C G + H+ Y +V IP+GA +I + + + S +Y+++ ++ +
Sbjct: 748 DNSSCKTVAGTFNTVHY--GYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEF 805
Query: 796 YLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR--NPGVA 852
LNG++ V R + +Y S E + +T + L++++L G+ NP V
Sbjct: 806 LLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVR 865
Query: 853 WEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPK 912
+ +++P +Q W CS C G + + V+ C+
Sbjct: 866 YSFNIPIEDKPQQFYWNSHGPW----QACSKPCQGERKRKLVCTRESDQLTVSDQRCDRL 921
Query: 913 TRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTR--RVHYDSEPVPASLC 970
+P PC C W V + S CS CG G ++ + C + R+ +E V C
Sbjct: 922 PQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFC 980
Query: 971 -PQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAV 1029
P PS+R+ C+ + W W ECS +C G ++R C +T R +L D+
Sbjct: 981 SSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNT----RNDVLDDSK 1036
Query: 1030 CTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRE 1089
CT + E +QRC + QW WS+C VTC +G + R + C G+ R
Sbjct: 1037 CTHQ------EKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ----FGEDR- 1085
Query: 1090 LASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTR 1149
L + C KP+ + C + P SW A PW QC+ +CG G Q R
Sbjct: 1086 LNDRMCDPETKPT-------SMQTCQQ--------PECASWQAGPWGQCSVTCGQGYQLR 1130
Query: 1150 SVQCLAG 1156
+V+C+ G
Sbjct: 1131 AVKCIIG 1137
Score = 156 bits (394), Expect = 1e-37
Identities = 99/317 (31%), Positives = 134/317 (42%), Gaps = 29/317 (9%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
S CSVSCG G C + +C +P G C+ CP W G WS
Sbjct: 1451 SSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKP-HGHRKCRGGRCP-KWKAGAWSQ 1508
Query: 939 CSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP-AWSAGPWAE 997
CS +CG G Q R V C H + + P P S + C CP W A W E
Sbjct: 1509 CSVSCGRGVQQRHVGCQIGTHKIARETECN--PYTRPESERDCQGPRCPLYTWRAEEWQE 1566
Query: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
C+ TCG+G R R V C N + + A C +P E+C LQ C + W+
Sbjct: 1567 CTKTCGEGSRYRKVVCVDDNKNE----VHGARCDVSKRPVDRESCSLQPC----EYVWIT 1618
Query: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRH 1117
WS+CSVTC +G ++R + C+E Y + E + + + P P H
Sbjct: 1619 GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP----------GTQPPSVH 1668
Query: 1118 PPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAG-GRPASGCLLHQKPSASLAC- 1175
P + P +W W C+ SCG GV RSVQCL +P+ C KP C
Sbjct: 1669 PCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCR 1728
Query: 1176 NTHFCPIAEKKDAFCKD 1192
N + C + + CK+
Sbjct: 1729 NVYNCELPQN----CKE 1741
Score = 150 bits (379), Expect = 7e-36
Identities = 96/306 (31%), Positives = 139/306 (45%), Gaps = 39/306 (12%)
Query: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACS 940
CS +C GG C + + N C + +P C+ CP W+ GNW C+
Sbjct: 1340 CSSTCAGGSQRRVVVCQDENGYTAND--CVERIKPDEQRA-CESGPCP-QWAYGNWGECT 1395
Query: 941 RTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSCP--PAWSAGPWAE 997
+ CGGG ++R V C R + E P C P R+ CN+ +CP AWS GPW+
Sbjct: 1396 KLCGGGIRTRLVVCQRS---NGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSS 1452
Query: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
CS +CG+G ++R V C + + S L C KP H C RC K W
Sbjct: 1453 CSVSCGRGHKQRNVYCMAKDGSH----LESDYCKHLAKPHGHRKCRGGRCPK-----WKA 1503
Query: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRH 1117
AWSQCSV+C RG Q+R + C G ++ +C+ +P E ER C CP +
Sbjct: 1504 GAWSQCSVSCGRGVQQRHVGCQ----IGTHKIARETECNPYTRP--ESERDCQGPRCPLY 1557
Query: 1118 PPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLA 1174
+W A W +CT +CG G + R V C+ + + C + ++P +
Sbjct: 1558 -----------TWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES 1606
Query: 1175 CNTHFC 1180
C+ C
Sbjct: 1607 CSLQPC 1612
Score = 149 bits (377), Expect = 1e-35
Identities = 106/343 (30%), Positives = 148/343 (43%), Gaps = 60/343 (17%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
SEC V+CG G + C + ++N C+P+T+P T + C+ C SW G W
Sbjct: 1062 SECLVTCGKGHKHRQVWCQFG-EDRLNDRMCDPETKP-TSMQTCQQPECA-SWQAGPWGQ 1118
Query: 939 CSRTCGGGAQSRPVQC-----------------TRRVHYDSEPVPASLCPQPAPSSRQAC 981
CS TCG G Q R V+C TR +P+ P AP +R++
Sbjct: 1119 CSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRS- 1177
Query: 982 NSQSCPPA-WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
+ S P W G W CS TCGKG R R V+C+ N S + ++ C + P+P E
Sbjct: 1178 -TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGS----VADESACATLPRPVAKE 1232
Query: 1041 ACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPK 1100
C + C QW WS CSVTC +G R + C V+ + +C
Sbjct: 1233 ECSVTPCG-----QWKALDWSSCSVTCGQGRATRQVMC----VNYSDHVIDRSECDQDYI 1283
Query: 1101 PSLELERACAPLPCPRHPPFA---------------AAGPSR------GSWFASPWSQCT 1139
P E ++ C+ PCP+ P + +A PSR W PW C+
Sbjct: 1284 P--ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACS 1341
Query: 1140 ASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCP 1181
++C GG Q R V C G A+ C+ KP AC + CP
Sbjct: 1342 STCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 129 bits (325), Expect = 1e-29
Identities = 94/352 (26%), Positives = 136/352 (38%), Gaps = 79/352 (22%)
Query: 880 ECSVSCGGGQMTVREGCYRDLKFQV-NMSFCNPKTRPVTGLVPCKVSACPP--------- 929
+CSV+CG G C V + + CN TRP T C++ +C P
Sbjct: 1118 QCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRP-TDTQDCELPSCHPPPAAPETRR 1176
Query: 930 --------SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQAC 981
W G+W+ CS TCG G + R V C R S ++ P P +++ C
Sbjct: 1177 STYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENGSVADESACATLPRPVAKEEC 1234
Query: 982 NSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
+ C W A W+ CS TCG+G R V C + + ++ + C + P +
Sbjct: 1235 SVTPCGQ-WKALDWSSCSVTCGQGRATRQVMCVNYSD----HVIDRSECDQDYIPETDQD 1289
Query: 1042 CLLQRC------------------HKPKKL-----------QWLVSAWSQCSVTCERGTQ 1072
C + C ++P+ QW W CS TC G+Q
Sbjct: 1290 CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQ 1349
Query: 1073 KRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA 1132
+R + C ++ + C KP + +RAC PCP+ W
Sbjct: 1350 RRVVVCQDE------NGYTANDCVERIKP--DEQRACESGPCPQ-------------WAY 1388
Query: 1133 SPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
W +CT CGGG++TR V C P C + KP CNTH CP
Sbjct: 1389 GNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
Score = 104 bits (259), Expect = 6e-22
Identities = 67/214 (31%), Positives = 93/214 (43%), Gaps = 21/214 (9%)
Query: 855 YSMPRLGTEKQPPAQPSYTW-AIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKT 913
Y+ P + Q P P YTW A EC+ +CG G + C D K +V+ + C+
Sbjct: 1540 YTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSK 1599
Query: 914 RPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQC----TRRVHYDSEPVPASL 969
RPV C + C W G WS CS TCG G + R V C T + +Y+
Sbjct: 1600 RPV-DRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTIN 1658
Query: 970 CPQPAPSSRQACNSQSCP--PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPD 1027
CP P S C + CP W G W CS +CG G +R+V C + P
Sbjct: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ------PS 1712
Query: 1028 AVCTSEPKPRMHEAC-------LLQRCHKPKKLQ 1054
+C ++ KP + C L Q C + K+L+
Sbjct: 1713 HLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLK 1746
Score = 38.9 bits (89), Expect = 0.030
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 13/72 (18%)
Query: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL------ 632
+ GP P W+ + +W C++ CGGG+ R +C + S+G +F + S L
Sbjct: 1379 ESGPCP---QWA-YGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCEILDKPPDR 1431
Query: 633 KLCNSQKCPRDS 644
+ CN+ CP D+
Sbjct: 1432 EQCNTHACPHDA 1443
Score = 33.5 bits (75), Expect = 1.3
Identities = 28/111 (25%), Positives = 44/111 (39%), Gaps = 19/111 (17%)
Query: 588 HWSDWSS--WSPCSRTCGGGVSHRSRLCTNPKPSH-GGKFCE--GSTRTLKLCNSQKCPR 642
H + WS+ WS CS +CG G R+ C SH +C+ + C +CP+
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
Query: 643 DSVDFRAAQCAEHNSRRFRGRHY-------------KWKPYTQVEDQDLCK 680
+QC+ R + RH + PYT+ E + C+
Sbjct: 1501 WKAG-AWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQ 1550
Score = 33.5 bits (75), Expect = 1.3
Identities = 22/88 (25%), Positives = 40/88 (45%), Gaps = 6/88 (6%)
Query: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCT--NPKPSHGGKFCEGSTRTL--KLC 635
+GP+ W W C++TCG G +R +C N HG + C+ S R + + C
Sbjct: 1550 QGPRCPLYTWRA-EEWQECTKTCGEGSRYRKVVCVDDNKNEVHGAR-CDVSKRPVDRESC 1607
Query: 636 NSQKCPRDSVDFRAAQCAEHNSRRFRGR 663
+ Q C + ++C+ + ++ R
Sbjct: 1608 SLQPCEYVWITGEWSECSVTCGKGYKQR 1635
Score = 30.8 bits (68), Expect = 8.3
Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 13/45 (28%)
Query: 569 CRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLC 613
CRGG+C K+ +WS CS +CG GV R C
Sbjct: 1493 CRGGRCPKW-------------KAGAWSQCSVSCGRGVQQRHVGC 1524
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 565 bits (1455), Expect = e-160
Identities = 371/1129 (32%), Positives = 536/1129 (47%), Gaps = 140/1129 (12%)
Query: 22 AEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMH 81
+++ P + G AA +PG+P+ +PPPP + P ++ + GD V
Sbjct: 119 SQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQH-------AEPDGDEVL----- 166
Query: 82 HQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTL-----GKTGTKSV 136
LR+ D ++ LR +AP F V+ G TG S
Sbjct: 167 -----------------LRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASA 209
Query: 137 QT--LPPEDFCFYQGSLRSHRNSSVALSTC-QGLSGMIRTEEADYFLRPLPSHLSWKLGR 193
PP+ CFY G++ H S + STC GL G I+ E F+ PL ++
Sbjct: 210 PQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAI---- 265
Query: 194 AAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRK 253
+ H +Y++ + E VT ++ +H SD +K GR K
Sbjct: 266 ----TGHPHRVYRQKR------SMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGK 315
Query: 254 KYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITT 313
+Y + LP EY N+ET+VV D M+ HG +
Sbjct: 316 RYS--------YKLPQEY-------------------NIETVVVADPAMVSYHGADAARR 348
Query: 314 YVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQ---- 369
++LTILNMV LF+ ++ +N+ ++ LILL + P L I HH + L SFC+WQ
Sbjct: 349 FILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEF 408
Query: 370 ----------SGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTI 419
S G+D T D AIL+T D C K+EPCDT+G A +SGMCS+ R C I
Sbjct: 409 GKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCII 468
Query: 420 NEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRN-GVFSWSPCSRQY 478
ED GL LAFTIAHE GHN G+ HD + C + + G+N G SWS CS++
Sbjct: 469 AEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKED 528
Query: 479 LHKFLSTAQAICLAD-QPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDI 537
L +FL + + CL P+ V P KLPG Y A+ QC+ FG A C + + I
Sbjct: 529 LERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQ-EMQHVI 587
Query: 538 CKALWCHRIGRK-CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWS 596
C LWC G K C TK P +GT C WC+ G+C P+ G +WS WS
Sbjct: 588 CTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTS-RTSAPEHLAG---EWSLWS 643
Query: 597 PCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHN 656
PCSRTC G+S R R C P + C G + ++C + CP FR QC ++
Sbjct: 644 PCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYS 701
Query: 657 SRRFRGRH-YKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDG 715
R +H +W+ ++++ C L+C G + LS KV DGT C ++C +G
Sbjct: 702 VRTSSPKHILQWQ--AVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANG 759
Query: 716 ICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIR 775
C++VGCD +LGS A ED CGVCNGN +C I +G + H Y ++ IP+GAR I+
Sbjct: 760 RCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHTRGAGYVEVLVIPAGARRIK 818
Query: 776 IYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTN 835
+ E + SY+++R+A + +N W ++ G + +GTT Y R E + A GPT
Sbjct: 819 VVEEKPAHSYLALRDA-GKQSINSDWKIEHSGAFNLAGTTVHYVRR-GLWEKISAKGPTT 876
Query: 836 ETL-IVELLFQGRNPGVAWEYSMPR---LGTEKQPPAQPSYTWAIVR-SECSVSCGGGQM 890
L ++ LLFQ +N G+ +EY++P + +P + W +C +CGGG+
Sbjct: 877 APLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGER 936
Query: 891 TVREGCYRDLKFQVNM---SFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGA 947
C + + +++ C T+P + C C W + W+ CSRTCG G
Sbjct: 937 KTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGM 996
Query: 948 QSRPVQCTRRVHYDS-EPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGW 1006
QSR V CT+++ + C P P+S Q C Q C W AG W+ECS CGKG
Sbjct: 997 QSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGI 1056
Query: 1007 RKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACL-LQRCHKPKKLQWLVSAWSQCSV 1065
R R V C TNP + C +PR E C +C+ W + WS+CS+
Sbjct: 1057 RHRTVRC--TNPRKK--------CVLSTRPREAEDCEDYSKCY-----VWRMGDWSKCSI 1101
Query: 1066 TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
TC +G Q R ++C K ++G++ +C KP+ R C PC
Sbjct: 1102 TCGKGMQSRVIQCMHK-ITGRH----GNECFSSEKPA--AYRPCHLQPC 1143
Score = 124 bits (312), Expect = 4e-28
Identities = 85/309 (27%), Positives = 124/309 (40%), Gaps = 52/309 (16%)
Query: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP---QPAPSSRQACNSQSCP 987
W+ +W C TCGGG + V CT+ + + V C +P P R+ CN Q C
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRK-CNEQPCQ 977
Query: 988 PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
W W CS TCGKG + R VAC + + C PKP + C Q C
Sbjct: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDC 1036
Query: 1048 HKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
W WS+CSV C +G + R ++C KKC +P E E
Sbjct: 1037 ----MTVWEAGVWSECSVKCGKGIRHRTVRCTNP----------RKKCVLSTRPR-EAED 1081
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPASGCLL 1165
C W WS+C+ +CG G+Q+R +QC+ GR + C
Sbjct: 1082 CEDYSKCY-------------VWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFS 1128
Query: 1166 HQKPSASLACNTHFCPIAEKKD---------------AFCKDYFHWCYLVPQHGMCSHKF 1210
+KP+A C H P EK + + +C ++ + +C
Sbjct: 1129 SEKPAAYRPC--HLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMR 1186
Query: 1211 YGKQCCKTC 1219
+ ++CC+TC
Sbjct: 1187 WYQRCCETC 1195
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 529 bits (1363), Expect = e-150
Identities = 355/1195 (29%), Positives = 550/1195 (46%), Gaps = 156/1195 (13%)
Query: 60 YDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESL--HLRLKGSRHDFHMDLRTSSS 117
Y++V V+ G+ V + H R++R+ E H R F ++L +S
Sbjct: 40 YEVVIPERVNEFGE-VFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADAS 98
Query: 118 LVAPGFIVQTLGKTGTKSVQT-LPPEDF--CFYQGSLRSHRNSSVALSTCQGLSGMIRTE 174
+A G+ LG + ++ P D CFY+G + S + +S C GL+G + +
Sbjct: 99 FLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQ 158
Query: 175 EADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRS-TEPHAPGASEVLVTSRTWELAHQPL 233
+YFL P+ + G + H++Y++ V+ + P
Sbjct: 159 NGEYFLEPI---MKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPF 215
Query: 234 HS-----SDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNE 288
H+ DL + K+ G K +P L DE + K+ L+ R
Sbjct: 216 HTYSNMNEDLNV---MKERVLGHTSKNVP---------LKDERRHS--RKKRLISYPRY- 260
Query: 289 ELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDE 348
+E +V D K++ HG N+ Y+LT++++V+ ++KD +IG I+I +V L+++ E
Sbjct: 261 ---IEIMVTADAKVVSAHG-SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHRE 316
Query: 349 QPGLVISHHADHTLSSFCQWQSGLMGKDG---TRHDHAILLTGLDICSWKNEPCDTLGFA 405
+ G VI+ TL +FC WQ D + HD A+L+T DICS K E C+ LG +
Sbjct: 317 EEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSK-EKCNMLGLS 375
Query: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKK---SEGNIMSPTL 462
+ +C +SC INE+ GL AFTIAHE GH G+ HD + CK+ ++ ++M+P L
Sbjct: 376 YLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVMAPAL 434
Query: 463 AGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQF 522
+ +SWS CSR+Y+ +FL T CL D+P + Y P +LPG YD N QC+ F
Sbjct: 435 SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDE-EIYNLPSELPGSRYDGNKQCELAF 493
Query: 523 GEKAKLCMLDFKKDICKALWC---HRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGD 579
G +++C +IC LWC ++ + C T+ +P A+GT CG M CR G CV
Sbjct: 494 GPGSQMCP---HINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKET 550
Query: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
E +P +G W W +S CSRTCGGG+ +R C P+P +GG +C G + CN+
Sbjct: 551 E-TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDS 609
Query: 640 CPRDSVDFRAAQCAEHNSRRFR----GRHYKWKP-YTQVEDQDLCKLYCIAEGFDFFFSL 694
CP+ + DFR QC++ N + + +W P Y+ + +D CKLYC G ++F+ L
Sbjct: 610 CPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLL 669
Query: 695 SNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTK 754
+ V+DGTPC ++ ++C+ G C GCD+VL S A D CGVC G+NS+C G++
Sbjct: 670 KDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS 729
Query: 755 HHHTNQYYHMVTIPSGARSIRIYEMNVS----TSYISVRNALRRYYLNGHWTVDWPGR-- 808
H+ Y +V IP+GA ++ I + + S SY+++ +A + NG++ + +
Sbjct: 730 SHY--GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEI 787
Query: 809 -YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR--NPGVAWEYSMPRLGTEKQ 865
+ + T +Y S N E + +T + LI+++L G NP V + +++P
Sbjct: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
Query: 866 PPAQPSYTW-------------------------------------AIVRSECSVSC--- 885
P W + V C+ C
Sbjct: 848 FTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELR 907
Query: 886 -------------GGGQMTVREGC-----YRDLKFQVNMSFCNPKTRPVTGLVPCKVSAC 927
G G T+ C + QV+ +C + +P T + C +
Sbjct: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL-CHGNCV 966
Query: 928 PPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY---DSEPVPASLCPQPAPSSRQACNSQ 984
W WS CSR+CGGG +SR C + D+E C + + +R+ CN
Sbjct: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE------CQELSRVTRENCNEF 1020
Query: 985 SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLL 1044
SC P+W+A W+EC TCGKG ++R V C+ L D C S KP C L
Sbjct: 1021 SC-PSWAASEWSECLVTCGKGTKQRQVWCQ-----LNVDHLSDGFCNSSTKPESLSPCEL 1074
Query: 1045 QRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
C W V W C+ TC G Q R +KC + S L +C +PS
Sbjct: 1075 HTC-----ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPS-- 1124
Query: 1105 LERACAPLPCPRHPPFAAA------GPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
++C PC A W W+ C+ SCG G Q R V C
Sbjct: 1125 DRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC 1179
Score = 149 bits (377), Expect = 1e-35
Identities = 100/321 (31%), Positives = 139/321 (43%), Gaps = 46/321 (14%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
S+CS SCGGG+ + C + ++ + C +R C +CP SW+ WS
Sbjct: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRE--NCNEFSCP-SWAASEWSE 1032
Query: 939 CSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAEC 998
C TCG G + R V C V + S+ S P S C +C +W GPW C
Sbjct: 1033 CLVTCGKGTKQRQVWCQLNVDHLSDGFCNS---STKPESLSPCELHTCA-SWQVGPWGPC 1088
Query: 999 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKL----- 1053
+ TCG G++ R V C + SA +L D C +P ++C+L C KL
Sbjct: 1089 TTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVLTPCSFISKLETALL 1145
Query: 1054 ---------QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
QW +W+ CSV+C RGTQ R++ C + R C+HLP+P+
Sbjct: 1146 PTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRD----ALDRIADESYCAHLPRPA-- 1199
Query: 1105 LERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP--ASG 1162
E PC G W A WS C+ASCG G TR V C+ +P +
Sbjct: 1200 -EIWDCFTPC-------------GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY 1245
Query: 1163 CLLHQKPSASLACNTHFCPIA 1183
C +P C+ CP A
Sbjct: 1246 CDPEVRPLMEQECSLAACPPA 1266
Score = 143 bits (361), Expect = 9e-34
Identities = 94/321 (29%), Positives = 133/321 (41%), Gaps = 75/321 (23%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS-------- 930
S CS SCG G+ T R+ + ++ ++C+P+ RP+ C ++ACPP+
Sbjct: 1217 SPCSASCGHGK-TTRQVLCMNYHQPIDENYCDPEVRPLMEQ-ECSLAACPPAHSHFPSSP 1274
Query: 931 ---------------------------------WSVGNWSACSRTCGGGAQSRPVQCTRR 957
W G W +CS +C GG Q R V C
Sbjct: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ-- 1332
Query: 958 VHYDSEPVPASLCPQPA-PSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKST 1016
D AS C + P Q C CP W+ G W ECS TCG G + R V C+
Sbjct: 1333 ---DENGQSASYCDAASKPPELQQCGPGPCPQ-WNYGNWGECSQTCGGGIKSRLVICQFP 1388
Query: 1017 NPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFL 1076
N Q+L D C KP C + C P + W W+ CS +C +G + R +
Sbjct: 1389 N----GQILEDHNCEIVNKPPSVIQCHMHAC--PADVSWHQEPWTSCSASCGKGRKYREV 1442
Query: 1077 KCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWS 1136
C +++ R+L CS + KP +AC + CP SW A+ W+
Sbjct: 1443 FCIDQF----QRKLEDTNCSQVQKPPTH--KACRSVRCP-------------SWKANSWN 1483
Query: 1137 QCTASCGGGVQTRSVQCLAGG 1157
+C+ +CG GVQ R V C G
Sbjct: 1484 ECSVTCGSGVQQRDVYCRLKG 1504
Score = 125 bits (314), Expect = 2e-28
Identities = 97/349 (27%), Positives = 135/349 (38%), Gaps = 85/349 (24%)
Query: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVT---GLVPCKVSACPPSWSVGNWS 937
CSVSCG G C L + S+C RP PC W G+WS
Sbjct: 1164 CSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCG------EWQAGDWS 1217
Query: 938 ACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPAPSSRQACNSQSCPPA------- 989
CS +CG G +R V C ++Y +P+ + C P+ P Q C+ +CPPA
Sbjct: 1218 PCSASCGHGKTTRQVLC---MNYH-QPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSS 1273
Query: 990 ----------------------------------WSAGPWAECSHTCGKGWRKRAVACKS 1015
W GPW CS +C G + RAV C+
Sbjct: 1274 PVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD 1333
Query: 1016 TNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRF 1075
N + + C + KP LQ+C QW W +CS TC G + R
Sbjct: 1334 ENGQSA------SYCDAASKPPE-----LQQCGPGPCPQWNYGNWGECSQTCGGGIKSRL 1382
Query: 1076 LKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPW 1135
+ C ++ +G+ L C + KP + + C H A P+ SW PW
Sbjct: 1383 VIC--QFPNGQI--LEDHNCEIVNKPP-------SVIQCHMH-----ACPADVSWHQEPW 1426
Query: 1136 SQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
+ C+ASCG G + R V C+ + + C QKP AC + CP
Sbjct: 1427 TSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
Score = 117 bits (292), Expect = 9e-26
Identities = 87/275 (31%), Positives = 122/275 (44%), Gaps = 34/275 (12%)
Query: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACS 940
CS SC GG C +D Q + S+C+ ++P L C CP W+ GNW CS
Sbjct: 1316 CSSSCSGGLQHRAVVC-QDENGQ-SASYCDAASKPPE-LQQCGPGPCP-QWNYGNWGECS 1371
Query: 941 RTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP--AWSAGPWAEC 998
+TCGGG +SR V C E + +P PS Q C+ +CP +W PW C
Sbjct: 1372 QTCGGGIKSRLVICQFPNGQILEDHNCEIVNKP-PSVIQ-CHMHACPADVSWHQEPWTSC 1429
Query: 999 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVS 1058
S +CGKG + R V C + L D C+ KP H+AC RC W +
Sbjct: 1430 SASCGKGRKYREVFC----IDQFQRKLEDTNCSQVQKPPTHKACRSVRCP-----SWKAN 1480
Query: 1059 AWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHP 1118
+W++CSVTC G Q+R + C K V ++ + C +P +R C C +H
Sbjct: 1481 SWNECSVTCGSGVQQRDVYCRLKGVG----QVVEEMCDQSTRPC--SQRRCWSQDCVQH- 1533
Query: 1119 PFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
G RG C+ SC + ++C
Sbjct: 1534 ----KGMERGR------LNCSTSCERKDSHQRMEC 1558
Score = 108 bits (271), Expect = 2e-23
Identities = 91/364 (25%), Positives = 137/364 (37%), Gaps = 66/364 (18%)
Query: 880 ECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPP--SWSVGNWS 937
ECS +CGGG + C + C +P + ++ C + ACP SW W+
Sbjct: 1369 ECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS-VIQCHMHACPADVSWHQEPWT 1427
Query: 938 ACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAE 997
+CS +CG G + R V C + E S +P + +AC S CP +W A W E
Sbjct: 1428 SCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPP--THKACRSVRCP-SWKANSWNE 1484
Query: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
CS TCG G ++R V C+ + + +C +P C Q C + K ++
Sbjct: 1485 CSVTCGSGVQQRDVYCRLKGVGQ----VVEEMCDQSTRPCSQRRCWSQDCVQHKGME--- 1537
Query: 1058 SAWSQCSVTCERGTQKRFLKCAEKYV--------SGKYRELASKKCSHLP---------- 1099
CS +CER + ++C + + + L SK C + P
Sbjct: 1538 RGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADS 1597
Query: 1100 -------------------------KPSLELERACAPLPCPRHPPFAA-----AGPSRGS 1129
K L R CP P + +
Sbjct: 1598 SQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLAT 1657
Query: 1130 WFASPWSQCTASCGGGVQTRSVQCLA-GGRPASGCLLHQKPSASLACNTHFCPIAEKKDA 1188
W WS+C+ +CG G+ R V+C+ G + CL H KP A C + C K
Sbjct: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC----KSFT 1713
Query: 1189 FCKD 1192
CK+
Sbjct: 1714 TCKE 1717
Score = 68.6 bits (166), Expect = 4e-11
Identities = 69/287 (24%), Positives = 107/287 (37%), Gaps = 73/287 (25%)
Query: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
+ CS SCG G+ C + ++ + C+ +P T C+ CP SW +W+
Sbjct: 1427 TSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKA-CRSVRCP-SWKANSWNE 1484
Query: 939 CSRTCGGGAQSRPVQ--------------------CTRRVHYDSEPVP-----------A 967
CS TCG G Q R V C++R + + V +
Sbjct: 1485 CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCS 1544
Query: 968 SLCPQPAPSSRQACN--------------------SQSC--PPA---WSAGPWAECSHTC 1002
+ C + R C S++C PP ++C++ C
Sbjct: 1545 TSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNC 1604
Query: 1003 GKGWRKRAVACK---STNPSARAQLLPDAV--CTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
G +R+R C ST +L P C P ++++ C+ H W V
Sbjct: 1605 GFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQ-CINSCLHLAT---WKV 1660
Query: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
WS+CSVTC G KR +KC K+ L+S C + KP +
Sbjct: 1661 GKWSKCSVTCGIGIMKRQVKCITKH------GLSSDLCLNHLKPGAQ 1701
Score = 39.3 bits (90), Expect = 0.023
Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 14/107 (13%)
Query: 572 GQCVKYGDEGPKPTH------GHWSDWS--SWSPCSRTCGGGVSHRSRLCTNPK----PS 619
GQ Y D KP G W+ +W CS+TCGGG+ R +C P
Sbjct: 1336 GQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILED 1395
Query: 620 HGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYK 666
H + ++ C+ CP D V + ++ +GR Y+
Sbjct: 1396 HNCEIVNKPPSVIQ-CHMHACPAD-VSWHQEPWTSCSASCGKGRKYR 1440
Score = 38.9 bits (89), Expect = 0.030
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKCP 641
G W WSPCS +CG G + R LC N +C+ R L + C+ CP
Sbjct: 1209 GEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
Score = 36.2 bits (82), Expect = 0.20
Identities = 14/50 (28%), Positives = 27/50 (54%), Gaps = 3/50 (6%)
Query: 595 WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKCPR 642
W CS +C GG+ HR+ +C + + +C+ +++ L+ C CP+
Sbjct: 1313 WGSCSSSCSGGLQHRAVVCQD-ENGQSASYCDAASKPPELQQCGPGPCPQ 1361
Score = 32.3 bits (72), Expect = 2.8
Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSH-GGKFCEGSTR--TLKLCNSQKC 640
+SW+ CS TCG GV R C + C+ STR + + C SQ C
Sbjct: 1480 NSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 525 bits (1353), Expect = e-149
Identities = 346/1052 (32%), Positives = 491/1052 (46%), Gaps = 142/1052 (13%)
Query: 87 RAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCF 146
RA P LHL G D ++ LR ++ GF V+ G + P + CF
Sbjct: 73 RARPGERALLLHLPAFG--RDLYLQLRRDLRFLSRGFEVEEAGAARRRG----RPAELCF 126
Query: 147 YQGSLRSHRNSSVALSTCQ---GLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHV 203
Y G + H S V+LS C GL G+I+ + ++PL + +QG
Sbjct: 127 YSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN---------SQG------ 171
Query: 204 LYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKED 263
P + + R W L P S++ + + ++K +P ++
Sbjct: 172 ----------PFSGREHLIRRKWSLTPSP--SAEAQRPEQLCKVLTEKKKPTWGRPSRD- 218
Query: 264 LFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVS 323
R +R+ +R E VETLVV D M+Q HG E ++LT++NMV
Sbjct: 219 -----------WRERRNAIRL--TSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVY 265
Query: 324 ALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH--- 380
+F+ ++G INI + L+LL L I HH + +L SFC WQ+ G G R+
Sbjct: 266 NMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYG--GARYLGN 323
Query: 381 -------------DHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427
D A+ +T D C K+EPCDT+G A + G+CS R C + ED GL L
Sbjct: 324 NQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNL 383
Query: 428 AFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRN-GVFSWSPCSRQYLHKFLSTA 486
AFTIAHE GHN GM HD + + C + + GRN SWS CSR L FL +
Sbjct: 384 AFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSK 443
Query: 487 QAIC-LADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545
+ C L P+ + P KLPG Y AN QC+ FG A C + + +C LWC
Sbjct: 444 VSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHLMCAGLWCLV 502
Query: 546 IG-RKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTH--GHWSDWSSWSPCSRTC 602
G C+TK P +GT CG D WCR G+CV + P P H G WS W +WS CSRTC
Sbjct: 503 EGDTSCKTKLDPPLDGTECGADKWCRAGECV---SKTPIPEHVDGDWSPWGAWSMCSRTC 559
Query: 603 GGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRG 662
G G R R C NP P GG C G++ +C + CP+ FR QC H+ R
Sbjct: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD--RLSP 617
Query: 663 RHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGC 722
+ V+D+ C+LYC G + ++++V DGTPC ++C+ G C+++GC
Sbjct: 618 KKKGLLTAVVVDDKP-CELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGC 676
Query: 723 DNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVS 782
D ++GS A ED CGVC+G+ C + +G + S AR + +
Sbjct: 677 DGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----------------SHARGTALKDSGKG 720
Query: 783 TSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETL-IVE 841
+ +N W ++ PG ++ +GTT Y R E + A GPT L ++
Sbjct: 721 S-------------INSDWKIELPGEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHLMV 766
Query: 842 LLFQGRNPGVAWEYSMP--RLGTEKQPPAQPS---YTWAIVRSE-CSVSCGGGQMTVREG 895
LLF ++ G+ +EY++P R + P +P + W E CSV CGGG+
Sbjct: 767 LLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVS 826
Query: 896 CYRDLK---FQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPV 952
C R + VN S C +RP + C + C W G WS CS TC G Q R V
Sbjct: 827 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREV 886
Query: 953 QCTRRVHYDSEPVPASL-CPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAV 1011
C ++ + L CP P P++ Q+C Q C W A W++CS +CGKG KR V
Sbjct: 887 TCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTV 946
Query: 1012 ACKSTNPSARAQLLPDAVCTSEPKPRMHEACL-LQRCHKPKKLQWLVSAWSQCSVTCERG 1070
AC TN + C + +PR EAC C+ +W WS CS TC +G
Sbjct: 947 AC--TNSQGK--------CDASTRPRAEEACEDYSGCY-----EWKTGDWSTCSSTCGKG 991
Query: 1071 TQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Q R ++C K V+G++ +C L KP+
Sbjct: 992 LQSRVVQCMHK-VTGRH----GSECPALSKPA 1018
Score = 132 bits (333), Expect = 2e-30
Identities = 92/312 (29%), Positives = 129/312 (41%), Gaps = 58/312 (18%)
Query: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ---PAPSSRQACNSQSCP 987
W+ W CS CGGG + V CTR V+ + V S CPQ P P R+ CN C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRR-CNLHPCQ 862
Query: 988 PAWSAGPWAECSHTCGKGWRKRAVAC-----KSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
W AGPW+ CS TC KG++ R V C T+ + R P P+P ++C
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG------PRPAAVQSC 916
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Q C W S WSQCS +C +G KR + C + KC +P
Sbjct: 917 EGQDCLSI----WEASEWSQCSASCGKGVWKRTVACTN----------SQGKCDASTRP- 961
Query: 1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPA 1160
E AC W WS C+++CG G+Q+R VQC+ GR
Sbjct: 962 -RAEEACEDYS------------GCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHG 1008
Query: 1161 SGCLLHQKPSASLACNTHFC------------PIAEKKDAFCKDYFH-WCYLVPQHGMCS 1207
S C KP+ C C +A +D + +C ++ + +C
Sbjct: 1009 SECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQ 1068
Query: 1208 HKFYGKQCCKTC 1219
+ ++CC+TC
Sbjct: 1069 DMRWYQRCCQTC 1080
Score = 35.8 bits (81), Expect = 0.26
Identities = 53/253 (20%), Positives = 85/253 (33%), Gaps = 45/253 (17%)
Query: 471 WSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCK-------WQFG 523
WSPCS K + C+ P PG A C+ W+
Sbjct: 870 WSPCSAT-CEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEAS 928
Query: 524 EKAKLCMLDFKKDICK-ALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGP 582
E ++ C K + K + C KC+ P AE C Y
Sbjct: 929 EWSQ-CSASCGKGVWKRTVACTNSQGKCDASTRPRAEEA------------CEDYSG--- 972
Query: 583 KPTHGHWSDWSS--WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQ 638
+W + WS CS TCG G+ R C + G C ++ + C +
Sbjct: 973 ------CYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQE 1026
Query: 639 KCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQV-EDQDLCK-----LYCIAEGFDFFF 692
C D ++ + ++ +W Y +V +++LC+ C DF+
Sbjct: 1027 VC-NDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFY- 1084
Query: 693 SLSNKVKDGTPCS 705
+NK++ P S
Sbjct: 1085 --ANKMRQPPPNS 1095
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 512 bits (1319), Expect = e-145
Identities = 352/1141 (30%), Positives = 533/1141 (46%), Gaps = 129/1141 (11%)
Query: 11 LAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDH 70
L +LW++ A + E + A G+ + + P +R EY+LV+ +
Sbjct: 3 LLSLWLIAAALVEVRTS-----ADGQAGNEEMVQIDLPIKR-----YREYELVTPVSTNL 52
Query: 71 RGDYVSHEIMHHQRRRRAVPVSE-VESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQ--- 126
G Y+SH + ++R A VS E L + DFH+ L+ ++ LVAPG +V+
Sbjct: 53 EGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHE 112
Query: 127 ---------------TLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMI 171
G + +T P + C Y G + +SVA+S C GL+GMI
Sbjct: 113 TSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMI 172
Query: 172 RTEEADYFLRPLP--SHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELA 229
+++ +YF+ PL + + GR HV+YKRS AP + S+ +
Sbjct: 173 KSDNEEYFIEPLERGKQMEEEKGRI-------HVVYKRSAVEQAP-----IDMSKDFHYR 220
Query: 230 HQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEE 289
L D DL + L R +
Sbjct: 221 ESDLEGLD-------------------------DLGTVYGNIHQQLNETMRRRRHAGEND 255
Query: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
N+E L+ VD +++ HG E++ Y+LT++N+V+ ++ D ++G +IN+ +V +I+L +
Sbjct: 256 YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAK 315
Query: 350 P-GLVISHHADHTLSSFCQWQSGLMGKD---GTRHDHAILLTGLDICSWKNEPCDTLGFA 405
L+ + +L + C+W S D HDHAI LT D P G+A
Sbjct: 316 SISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYA 370
Query: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC--KKSEGNIMSPTLA 463
P++GMC RSCT+N + G AF +AHE+GH GM HDG+GN C + + G++M+P +
Sbjct: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQ 430
Query: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
+ WS CS Q L +++ + CL D P K PE LPG Y + QC++ FG
Sbjct: 431 AAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPE-LPGINYSMDEQCRFDFG 487
Query: 524 EKAKLCMLDFKKDICKALWCHRIGRK--CETKFMPAAEGTICGHDMWCRGGQCVKYGDEG 581
K+C D CK LWC C+TK P +GT C WC G C+ + +
Sbjct: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCM-WKNAN 546
Query: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCP 641
+ G+W W+ + CSRTCG GV R+R C NP P +GG+ C G +LCN+++C
Sbjct: 547 QQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQ 606
Query: 642 RDSVDFRAAQCAEHNSR-RFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKD 700
+ DFRA QC + NS ++ + W PY + + C LYC ++ + V D
Sbjct: 607 KHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHD 666
Query: 701 GTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTN 759
GT CS +D ++C+ G C +VGCD +GS+ VED CGVC G+NS C +G +T+
Sbjct: 667 GTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKL 726
Query: 760 QYYHMVTIPSGARSIRIYEMNVSTSYISVRN-ALRRYYLNGHWTVDWPGRYKFSGTTFDY 818
Y M IP GAR + I E S ++++N A Y LNG + G +DY
Sbjct: 727 GYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDY 786
Query: 819 RRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEY-------SMPRLGTEKQPPAQ-P 870
++ E+L GP ++ +IV ++ Q + + Y S+P + + +
Sbjct: 787 NIE-DDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELD 845
Query: 871 SYTWAIVR-SECSVSCGGGQMTVREGCYR--DLKFQVNMSFC--NPKTRPVTGLVPCKVS 925
++ WA+ S+CS CGGG + GC R D K V+ SFC N K +P+ + C +
Sbjct: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNK-MVHRSFCEANKKPKPIRRM--CNIQ 902
Query: 926 ACP-PSWSVGNWSACSRTCG-GGAQSRPVQCTR-RVHYDSEPVPASLCPQPAPSSRQACN 982
C P W W C++TCG G Q R V+C + + + V + C P SR+ CN
Sbjct: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
Query: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
CP W GPW+ECS TCG+G R V C++ + C E KP AC
Sbjct: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----------CDGE-KPESVRAC 1010
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
L C+ L S+ C+ R+ C+ + E SK+ S LP P
Sbjct: 1011 QLPPCNDEPCL-------GDKSIFCQMEVLARY--CSIPGYNKLCCESCSKRSSTLPPPY 1061
Query: 1103 L 1103
L
Sbjct: 1062 L 1062
Score = 105 bits (262), Expect = 3e-22
Identities = 68/237 (28%), Positives = 102/237 (43%), Gaps = 38/237 (16%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
W+ W++CS CG G++ C+ + + +++ + C + KP+ + C +Q C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDN---KMVHRSFCEANKKPKPIRRMCNIQECT 905
Query: 1049 KPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
P W+ W C+ TC G Q R ++C + + G R + SK C +P E R
Sbjct: 906 HPL---WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRP--ESRR 959
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
C +PCP W PWS+C+ +CG G + R V C AG +
Sbjct: 960 PCNRVPCP------------AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDG-----E 1002
Query: 1168 KPSASLACNTHFC---PIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
KP + AC C P K FC+ Y CS Y K CC++CSK
Sbjct: 1003 KPESVRACQLPPCNDEPCLGDKSIFCQMEVLARY-------CSIPGYNKLCCESCSK 1052
Score = 30.8 bits (68), Expect = 8.3
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 7/57 (12%)
Query: 1128 GSWFASPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHF 1179
GSW + + C+ +CG GV+ R+ QC + GG+ G + + C HF
Sbjct: 555 GSW--TKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 511 bits (1315), Expect = e-144
Identities = 354/1076 (32%), Positives = 519/1076 (48%), Gaps = 115/1076 (10%)
Query: 40 PSVPRPPPPA--------ERPGWM--EKGEYDLVSAYEVDHRGDYVSHEIMHHQRR---- 85
P +P PPPPA + PG E L D +G VSH + R
Sbjct: 26 PLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR 85
Query: 86 -RRAVPV---------SEVESLHL--RLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGT 133
RRA PV E HL + D H+ LR ++ LVAPG ++ G+ GT
Sbjct: 86 ARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGT 145
Query: 134 KSVQTLPPEDFCFYQGSLRSHRN-SSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLG 192
V+ L C Y G + SSVALS C GL+G+IR EE ++F+ PL L+ +
Sbjct: 146 TRVEPLLGS--CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQ-- 201
Query: 193 RAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRR 252
A QG HV+Y+R G + L T + + L S LG
Sbjct: 202 EAEQGRV--HVVYRRPPTSPPLGGPQALDTGASLD----SLDSLSRALG----------- 244
Query: 253 KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENIT 312
+L + S R R R +++ N+E L+ VD ++Q HG E++
Sbjct: 245 -------------VLEEHANSSRRRAR---RHAADDDYNIEVLLGVDDSVVQFHGKEHVQ 288
Query: 313 TYVLTILNMVSALFKDGTIGGNINIAIVGLILLE-DEQPGLVISHHADHTLSSFCQWQSG 371
Y+LT++N+V+ ++ D ++G +IN+ +V +ILL + L+ + +L + C+W +
Sbjct: 289 KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRW-AY 347
Query: 372 LMGKDGTRHD----HAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427
L K T HD HAI LT D P G+AP++GMC RSCT+N + G
Sbjct: 348 LQQKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSS 402
Query: 428 AFTIAHESGHNFGMIHDGEGNMCKKSE--GNIMSPTLAGRNGVFSWSPCSRQYLHKFLST 485
AF +AHE+GH GM HDG+GN C G+IM+P + F WS CS+Q L ++L +
Sbjct: 403 AFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS 462
Query: 486 AQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545
CL D P ++ +LPG Y N QC++ FG +C D CK LWC
Sbjct: 463 YD--CLLDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSH 519
Query: 546 IGRK--CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCG 603
C+TK P +GT+C C G C+ + K G W WS + CSRTCG
Sbjct: 520 PDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK-RDGSWGAWSPFGSCSRTCG 578
Query: 604 GGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRG- 662
GV R+R C NP P++GG+ C G +LC+ Q CP DFR QC + + G
Sbjct: 579 TGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGD 638
Query: 663 RHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGICERVG 721
+ W P+ + ++ C LYC + S+ V DGT CS +D+ ++C+ G C +VG
Sbjct: 639 AQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVG 698
Query: 722 CDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV 781
CD V+GS ED CGVC G+NS C + +G +T+ + Y M IP+GAR + I E++
Sbjct: 699 CDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDA 758
Query: 782 STSYISVRN-ALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLI 839
++ +++V+N ++ LN VD + + G ++Y R + E L GP + T+
Sbjct: 759 TSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY-RDEDGRETLQTMGPLHGTIT 817
Query: 840 VELLFQG-RNPGVAWEYSM--PRLGTEKQPPAQPS---YTWAIVR-SECSVSCGGGQMTV 892
V ++ G + ++Y + L + + Y WA+ + S CS CGGG
Sbjct: 818 VLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFT 877
Query: 893 REGCYRDLKFQ-VNMSFCNPKTRPVTGLVPCKVSAC-PPSWSVGNWSACSRTCG-GGAQS 949
+ GC R L + V+ FC ++P C C P W G W CS+TCG G Q
Sbjct: 878 KYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQV 937
Query: 950 RPVQCTRRVHYD-SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRK 1008
R V+C + +H + + V A C P SR+AC+ + CP W AGPW++CS TCG G ++
Sbjct: 938 RSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQE 997
Query: 1009 RAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHK----PKK----LQWL 1056
R V C++ + S +C E +P C L C + P K +QWL
Sbjct: 998 RPVLCRTADDSF-------GIC-QEERPETARTCRLGPCPRNISDPSKKSYVVQWL 1045
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/263 (26%), Positives = 100/263 (38%), Gaps = 52/263 (19%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
W+ W+ CS CG G + C+ +++ C + KP+ + AC Q C
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDH---KMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 1049 KPKKLQWLVSAWSQCSVTCER-GTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
+P W+ W CS TC R G Q R ++C + R + +K C+ +P E R
Sbjct: 915 QPV---WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RP--ESRR 968
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
AC+ CP G W A PWSQC+ +CG G Q R V C + G +
Sbjct: 969 ACSRELCP------------GRWRAGPWSQCSVTCGNGTQERPVLCRTAD-DSFGICQEE 1015
Query: 1168 KPSASLACNTHFCPIAEKKDAFCKDY-FHW--------------------------CYLV 1200
+P + C CP D K Y W C +
Sbjct: 1016 RPETARTCRLGPCP-RNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRME 1074
Query: 1201 PQHGMCSHKFYGKQCCKTCSKSN 1223
CS Y K CCK+C+ N
Sbjct: 1075 VLSRYCSIPGYNKLCCKSCNLYN 1097
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 22/135 (16%)
Query: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
+W + WS CS C G+Q C + ++ + C+ L KP + RAC P
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRL---DHKMVHRGFCAALSKPK-AIRRACNPQE 912
Query: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCG-GGVQTRSVQCLAGGRPASGCLLHQK---- 1168
C S+ W W C+ +CG G+Q RSV+C+ + +H K
Sbjct: 913 C-----------SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND 961
Query: 1169 --PSASLACNTHFCP 1181
P + AC+ CP
Sbjct: 962 ARPESRRACSRELCP 976
Score = 37.0 bits (84), Expect = 0.12
Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 17/89 (19%)
Query: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHFCP 1181
GSW A SP+ C+ +CG GV+ R+ QC GGR SG + C+ CP
Sbjct: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQ-----LCSRQDCP 616
Query: 1182 --IAEKKDAFCKDYFHWCYLVPQHGMCSH 1208
+A+ ++ C+ + L +HG H
Sbjct: 617 DSLADFREEQCRQW----DLYFEHGDAQH 641
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 469 bits (1207), Expect = e-132
Identities = 321/1043 (30%), Positives = 477/1043 (45%), Gaps = 103/1043 (9%)
Query: 31 GPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVP 90
GPAAA+ GS V PP + V+ + G + H
Sbjct: 59 GPAAASAGSMVVDTPPTLPRHSSHLR------VARSPLHPGGTLWPGRVGRH-------- 104
Query: 91 VSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGS 150
SL+ + + H+ LR + LV PG V+ + + + P C Y G
Sbjct: 105 -----SLYFNVTVFGKELHLRLRPNRRLVVPGSSVEW--QEDFRELFRQPLRQECVYTGG 157
Query: 151 LRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTE 210
+ ++VA+S C GL+G+IRT+ D+F+ PL K + S +HV+Y+R
Sbjct: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEK-----EASGRTHVVYRRE-- 210
Query: 211 PHAPGASEVLVTSRTWELAHQPLHSSDLRLG-LPQKQHFCGRRKKYMPQPPKEDLFILPD 269
+ W LH+ LG LP L ++ D
Sbjct: 211 ----------AVQQEWAEPDGDLHNEAFGLGDLPNL------------------LGLVGD 242
Query: 270 EYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDG 329
+ R +R + ++E L+VVD +++ HG E++ YVLT++N+V ++ D
Sbjct: 243 QLGDTERKRRHA----KPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDE 298
Query: 330 TIGGNINIAIVGLILLEDEQP-GLVISHHADHTLSSFCQWQSGLMGKD---GTRHDHAIL 385
++G +INIA+V LI++ Q L+ + +L C+W +D HDH +
Sbjct: 299 SLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVF 358
Query: 386 LTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 445
LT D P G+AP++GMC RSC +N + G AF IAHE+GH GM HDG
Sbjct: 359 LTRQDF-----GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG 413
Query: 446 EGNMC--KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKY 503
+GN C + S G++M+P + F WS CS+ L ++L + CL D P +
Sbjct: 414 QGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDPFD-PAWPQ 470
Query: 504 PEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK--CETKFMPAAEGT 561
P +LPG Y + QC++ FG + C+ + CK LWC C+TK P +GT
Sbjct: 471 PPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGT 530
Query: 562 ICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
C WC G C+ E G WS W+ + CSR+CGGGV RSR C NP P++G
Sbjct: 531 ECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYG 590
Query: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRR-FRGRHYKWKPYTQVEDQDLCK 680
G+ C G ++CNS++CP DFRA QCA+ NS + + W PY +D C+
Sbjct: 591 GRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCE 650
Query: 681 LYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCN 739
L C + ++ V DGT CS D +VC G C VGCD +GS +D CGVC
Sbjct: 651 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 710
Query: 740 GNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNG 799
G+NS C +G K +V IP+GAR I+I + S I V+N + ++
Sbjct: 711 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILN 770
Query: 800 HWTVDWPGRYKFSGTTFDYRRSYNE-PENLIATGPTNETLIVELL---FQGRNPGVAWEY 855
+ R F+ ++ + + E+L +GP E + + L G +A++Y
Sbjct: 771 PKGKEATSR-TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY 829
Query: 856 -----SMPRLGTEK-QPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDL-KFQVNMS 907
+P +G+ +Y WA+ + CS +CGGG + GC R V
Sbjct: 830 VIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 889
Query: 908 FCNPKTRPVTGLVPCKVSAC-PPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPV 965
C+ K RP C C P W W ACSR+CG G Q+R +QC + + V
Sbjct: 890 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 949
Query: 966 -PASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL 1024
PA C P +R+ C CP W G W++CS TCG+G ++R V C+ TN ++
Sbjct: 950 MPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHC 1008
Query: 1025 LPDAVCTSEPKPRMHEACLLQRC 1047
D +P + C L C
Sbjct: 1009 EGD-------RPDTVQVCSLPAC 1024
Score = 80.9 bits (198), Expect = 7e-15
Identities = 51/193 (26%), Positives = 78/193 (40%), Gaps = 24/193 (12%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
W+ WA CS CG G + C+ Q +C + +P+ + C C
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQR---HLCDHKKRPKPIRRRCNQHPCS 910
Query: 1049 KPKKLQWLVSAWSQCSVTCER-GTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
+P W+ W CS +C + G Q R ++C +G ++ + +K C+ +P E R
Sbjct: 911 QPV---WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRP--EARR 964
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
C +PCP W WSQC+A+CG G+Q R V C C
Sbjct: 965 PCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGD 1011
Query: 1168 KPSASLACNTHFC 1180
+P C+ C
Sbjct: 1012 RPDTVQVCSLPAC 1024
Score = 53.9 bits (128), Expect = 9e-07
Identities = 39/136 (28%), Positives = 53/136 (38%), Gaps = 24/136 (17%)
Query: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
+W + +W+ CS C G Q C + + + C H +P + R C P
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRR---RDHHMVQRHLCDHKKRPK-PIRRRCNQHP 908
Query: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQC---LAGG----RPASGCLL 1165
C S+ W W C+ SCG GVQTR +QC L+ G PA C
Sbjct: 909 C-----------SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-A 956
Query: 1166 HQKPSASLACNTHFCP 1181
+P A C CP
Sbjct: 957 GDRPEARRPCLRVPCP 972
Score = 34.7 bits (78), Expect = 0.57
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 15/62 (24%)
Query: 1128 GSWFASPWSQ---CTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHF 1179
G W S W++ C+ SCGGGV++RS C GGR G + + CN+
Sbjct: 556 GGW--SSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQ-----VCNSEE 608
Query: 1180 CP 1181
CP
Sbjct: 609 CP 610
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 466 bits (1200), Expect = e-131
Identities = 320/1043 (30%), Positives = 476/1043 (45%), Gaps = 106/1043 (10%)
Query: 31 GPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVP 90
GPAAA+ GS V PP + V+ + G + H
Sbjct: 59 GPAAASAGSMVVDTPPTLPRHSSHLR------VARSPLHPGGTLWPGRVGRH-------- 104
Query: 91 VSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGS 150
SL+ + + H+ LR + LV PG V+ + + + P C Y G
Sbjct: 105 -----SLYFNVTVFGKELHLRLRPNRRLVVPGSSVEW--QEDFRELFRQPLRQECVYTGG 157
Query: 151 LRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTE 210
+ ++VA+S C GL+G+IRT+ D+F+ PL K + S +HV+Y+R
Sbjct: 158 VTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEK-----EASGRTHVVYRRE-- 210
Query: 211 PHAPGASEVLVTSRTWELAHQPLHSSDLRLG-LPQKQHFCGRRKKYMPQPPKEDLFILPD 269
+ W LH+ LG LP L ++ D
Sbjct: 211 ----------AVQQEWAEPDGDLHNEAFGLGDLPNL------------------LGLVGD 242
Query: 270 EYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDG 329
+ R +R + ++E L+VVD +++ HG E++ YVLT++N+V ++ D
Sbjct: 243 QLGDTERKRRHA----KPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDE 298
Query: 330 TIGGNINIAIVGLILLEDEQP-GLVISHHADHTLSSFCQWQSGLMGKD---GTRHDHAIL 385
++G +INIA+V LI++ Q L+ + +L C+W +D HDH +
Sbjct: 299 SLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVF 358
Query: 386 LTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 445
LT D G+AP++GMC RSC +N + G AF IAHE+GH GM HDG
Sbjct: 359 LTRQDF--------GPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDG 410
Query: 446 EGNMC--KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKY 503
+GN C + S G++M+P + F WS CS+ L ++L + CL D P +
Sbjct: 411 QGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYD--CLLDDPFD-PAWPQ 467
Query: 504 PEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK--CETKFMPAAEGT 561
P +LPG Y + QC++ FG + C+ + CK LWC C+TK P +GT
Sbjct: 468 PPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGT 527
Query: 562 ICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
C WC G C+ E G WS W+ + CSR+CGGGV RSR C NP P++G
Sbjct: 528 ECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYG 587
Query: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRR-FRGRHYKWKPYTQVEDQDLCK 680
G+ C G ++CNS++CP DFRA QCA+ NS + + W PY +D C+
Sbjct: 588 GRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCE 647
Query: 681 LYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCN 739
L C + ++ V DGT CS D +VC G C VGCD +GS +D CGVC
Sbjct: 648 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 707
Query: 740 GNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNG 799
G+NS C +G K +V IP+GAR I+I + S I V+N + ++
Sbjct: 708 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILN 767
Query: 800 HWTVDWPGRYKFSGTTFDYRRSYNE-PENLIATGPTNETLIVELL---FQGRNPGVAWEY 855
+ R F+ ++ + + E+L +GP E + + L G +A++Y
Sbjct: 768 PKGKEATSR-TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY 826
Query: 856 -----SMPRLGTEK-QPPAQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDL-KFQVNMS 907
+P +G+ +Y WA+ + CS +CGGG + GC R V
Sbjct: 827 VIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 886
Query: 908 FCNPKTRPVTGLVPCKVSAC-PPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPV 965
C+ K RP C C P W W ACSR+CG G Q+R +QC + + V
Sbjct: 887 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 946
Query: 966 -PASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL 1024
PA C P +R+ C CP W G W++CS TCG+G ++R V C+ TN ++
Sbjct: 947 MPAKACAGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHC 1005
Query: 1025 LPDAVCTSEPKPRMHEACLLQRC 1047
D +P + C L C
Sbjct: 1006 EGD-------RPDTVQVCSLPAC 1021
Score = 80.9 bits (198), Expect = 7e-15
Identities = 51/193 (26%), Positives = 78/193 (40%), Gaps = 24/193 (12%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
W+ WA CS CG G + C+ Q +C + +P+ + C C
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQR---HLCDHKKRPKPIRRRCNQHPCS 907
Query: 1049 KPKKLQWLVSAWSQCSVTCER-GTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
+P W+ W CS +C + G Q R ++C +G ++ + +K C+ +P E R
Sbjct: 908 QPV---WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRP--EARR 961
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
C +PCP W WSQC+A+CG G+Q R V C C
Sbjct: 962 PCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC-EGD 1008
Query: 1168 KPSASLACNTHFC 1180
+P C+ C
Sbjct: 1009 RPDTVQVCSLPAC 1021
Score = 53.9 bits (128), Expect = 9e-07
Identities = 39/136 (28%), Positives = 53/136 (38%), Gaps = 24/136 (17%)
Query: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
+W + +W+ CS C G Q C + + + C H +P + R C P
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRR---RDHHMVQRHLCDHKKRPK-PIRRRCNQHP 905
Query: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQC---LAGG----RPASGCLL 1165
C S+ W W C+ SCG GVQTR +QC L+ G PA C
Sbjct: 906 C-----------SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-A 953
Query: 1166 HQKPSASLACNTHFCP 1181
+P A C CP
Sbjct: 954 GDRPEARRPCLRVPCP 969
Score = 34.7 bits (78), Expect = 0.57
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 15/62 (24%)
Query: 1128 GSWFASPWSQ---CTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHF 1179
G W S W++ C+ SCGGGV++RS C GGR G + + CN+
Sbjct: 553 GGW--SSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQ-----VCNSEE 605
Query: 1180 CP 1181
CP
Sbjct: 606 CP 607
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 459 bits (1180), Expect = e-129
Identities = 304/890 (34%), Positives = 442/890 (49%), Gaps = 64/890 (7%)
Query: 99 LRLKGSRHDFHMDLRTSSSLVAPGFIVQTLG-KTGTKSVQTLPPEDF--CFYQGSLRSHR 155
LRL ++LR SS +APGF +Q +G K+G+++ LP D CFY G++
Sbjct: 76 LRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSET--PLPETDLAHCFYSGTVNGDP 133
Query: 156 NSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPG 215
+S+ ALS C+G+ G YF++PLP+ S +L AA G P L + G
Sbjct: 134 SSAAALSLCEGVRGAFYLLGEAYFIQPLPA-ASERLATAAPGEKPPAPLQFHLLRRNRQG 192
Query: 216 ASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRK--KYMPQPPKEDLFILPDEYKS 273
+V T + +P ++ + + G + ++ PQ P P S
Sbjct: 193 --DVGGTCGVVDDEPRPTGKAETE---DEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGS 247
Query: 274 CLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGG 333
K+ + SHR VET++V D+ M + HG + Y+LT+ ++ + L+K +I
Sbjct: 248 I--RKKRFVSSHRY----VETMLVADQSMAEFHG-SGLKHYLLTLFSVAARLYKHPSIRN 300
Query: 334 NINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQ---SGLMGKDGTRHDHAILLTGLD 390
++++ +V ++++ DEQ G ++ +A TL +FC WQ + +D +D AIL T D
Sbjct: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
Query: 391 ICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC 450
+C ++ CDTLG A + +C RSC++ ED GL AFT AHE GH F M HD + C
Sbjct: 361 LCG--SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQC 417
Query: 451 KKSEG-----NIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPE 505
G ++M+ L+ + WSPCS + FL CL D KP + P
Sbjct: 418 ASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMD--KPQNPIQLPG 475
Query: 506 KLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK---CETKFMPAAEGTI 562
LPG YDAN QC++ FGE +K C C LWC C+TK P A+GT
Sbjct: 476 DLPGTSYDANRQCQFTFGEDSKHC--PDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTS 533
Query: 563 CGHDMWCRGGQCVKYGDEG--PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSH 620
CG WC G+CV D P HG W W W CSRTCGGGV + R C NP P +
Sbjct: 534 CGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKN 593
Query: 621 GGKFCEGSTRTLKLCNSQKCP-RDSVDFRAAQCAEHN----SRRFRGRHYKWKP-YTQVE 674
GGK+CEG + CN + CP + FR QC HN + G +W P Y V
Sbjct: 594 GGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVS 653
Query: 675 DQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDV 734
+D CKL C A+G +FF L KV DGTPCS DS +VC+ G C + GCD ++ S D
Sbjct: 654 PKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDK 713
Query: 735 CGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV-----STSYISVR 789
CGVC GN S C G T Y+ ++TIP+GA +I + + N + S+++++
Sbjct: 714 CGVCGGNGSTCKKISGSVTS--AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIK 771
Query: 790 NALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR- 847
A Y LNG +T+ + + G Y S E + + P E L +++L G
Sbjct: 772 AADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNA 831
Query: 848 -NPGVAWEYSMPRLGTEKQPPAQPSYT-WAIVR-SECSVSCGGGQMTVREGCYRDLKFQV 904
P + + Y + + ++ A P+++ W I ECS SC G C RD+ Q
Sbjct: 832 LRPKIKYTYFVKK--KKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC-RDINGQ- 887
Query: 905 NMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQC 954
S C + +P + PC C P W +G WS+CS+TCG G + R ++C
Sbjct: 888 PASECAKEVKPAS-TRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSLKC 935
Score = 72.0 bits (175), Expect = 3e-12
Identities = 40/113 (35%), Positives = 51/113 (45%), Gaps = 15/113 (13%)
Query: 989 AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH 1048
AW W ECS +C GW++R V C+ N P + C E KP C C
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKPASTRPCADHPCP 910
Query: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKP 1101
QW + WS CS TC +G +KR LKC +S L+ + C L KP
Sbjct: 911 -----QWQLGEWSSCSKTCGKGYKKRSLKC----LSHDGGVLSHESCDPLKKP 954
Score = 63.9 bits (154), Expect = 9e-10
Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 26/132 (19%)
Query: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
W++ W +CS +CE G Q+R ++C + ++G+ + +C+ KP+ R CA PC
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRD--INGQ----PASECAKEVKPAST--RPCADHPC 909
Query: 1115 PRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQK--PSAS 1172
P+ W WS C+ +CG G + RS++CL+ G L H+ P
Sbjct: 910 PQ-------------WQLGEWSSCSKTCGKGYKKRSLKCLSHD---GGVLSHESCDPLKK 953
Query: 1173 LACNTHFCPIAE 1184
FC +AE
Sbjct: 954 PKHFIDFCTMAE 965
Score = 48.9 bits (115), Expect = 3e-05
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 1125 PSRGSWFASPWSQCTASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCP 1181
P+ +W W +C+ SC G Q R V+C G+PAS C KP+++ C H CP
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCP 910
Score = 37.7 bits (86), Expect = 0.068
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 1/58 (1%)
Query: 1125 PSRGSW-FASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
P GSW PW C+ +CGGGVQ +C G K +CN CP
Sbjct: 557 PFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
Score = 37.0 bits (84), Expect = 0.12
Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 12/62 (19%)
Query: 930 SWSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVP---ASLCPQPAPSSRQACNSQS 985
SW + G W CSRTCGGG Q +C PVP C R +CN +
Sbjct: 561 SWGMWGPWGDCSRTCGGGVQYTMREC-------DNPVPKNGGKYCEGKRVRYR-SCNLED 612
Query: 986 CP 987
CP
Sbjct: 613 CP 614
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 444 bits (1142), Expect = e-124
Identities = 325/990 (32%), Positives = 448/990 (45%), Gaps = 127/990 (12%)
Query: 95 ESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSH 154
+ L ++ + DF++ L + +AP F + LG CFY G + +
Sbjct: 51 QGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAE 110
Query: 155 RNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAP 214
+S A+S C GL G A+Y + PLP+ + R +QG+ H+L +R P
Sbjct: 111 PDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGA---HLLQRRGV----P 163
Query: 215 GASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYK-- 272
G TSR CG + P + D YK
Sbjct: 164 GGPSGDPTSR------------------------CGVASGWNPA-----ILRALDPYKPR 194
Query: 273 -SCLRHKRSLLRSHRNEEL-----NVETLVVVDKKMMQNHGHENITTYVLTILNMVSALF 326
+ RS RS R + VETLVV D+ M++ HG + + Y+LT+L + L+
Sbjct: 195 RAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLY 253
Query: 327 KDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH----DH 382
+ +I INI +V ++LL D G ++ +A TL +FC WQ L K +H D
Sbjct: 254 RHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL-NKVSDKHPEYWDT 312
Query: 383 AILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMI 442
AIL T D+C CDTLG A + MC RSC++ ED GL AFT AHE GH F M
Sbjct: 313 AILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMP 370
Query: 443 HDGEGNMCKKSEGNI-----MSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKP 497
HD +C++ G + MSPTL + WS CS + FL + CL DQP
Sbjct: 371 HDNV-KVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPS- 428
Query: 498 VKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK---CETKF 554
K PE LPG Y + QC+ FG +K C C LWC + C+T+
Sbjct: 429 -KPISLPEDLPGASYTLSQQCELAFGVGSKPCPY---MQYCTKLWCTGKAKGQMVCQTRH 484
Query: 555 MPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCT 614
P A+GT CG C G CV+ + G W+ W + PCSRTCGGGV R CT
Sbjct: 485 FPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCT 544
Query: 615 NPKPSHGGKFCEGSTRTLKLCNSQKCPRDS--VDFRAAQCAEHNSRRFRGRH----YKWK 668
NP P++GGK+CEG + CN + CP + FR QC N W
Sbjct: 545 NPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWV 604
Query: 669 P-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLG 727
P Y+ V +D CKL C A G +F+ L+ KV DGT CS DS +VC+ G C + GCD LG
Sbjct: 605 PKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLG 664
Query: 728 SDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV-----S 782
S D CGVC G+N +C GL+TK H Y +V IP+GA SI I +
Sbjct: 665 SKKRFDKCGVCGGDNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGD 722
Query: 783 TSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVE 841
+Y++++N+ +Y LNGH+ V R G+ Y + E+L A+ P E L VE
Sbjct: 723 DNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVE 782
Query: 842 LLFQGR--NPGVAWEYSMPRLGTEKQP--PAQPSYTWAIVRSECSVSCGGGQMTVREGCY 897
+L G+ P V + + +P+ E + P P + S S+S
Sbjct: 783 VLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLS------------- 829
Query: 898 RDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRR 957
QV P RP P W G+W CS +CG G Q R V C R
Sbjct: 830 ----NQVE----QPDDRP------------PARWVAGSWGPCSASCGSGLQKRAVDC--R 867
Query: 958 VHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTN 1017
VPA P QAC + C P W W+ CS +CG+G+++R++ C
Sbjct: 868 GSAGQRTVPACDAAH-RPVETQAC-GEPC-PTWELSAWSPCSKSCGRGFQRRSLKCVGHG 924
Query: 1018 PSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
+LL C KP+ + C+L+ C
Sbjct: 925 ----GRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 71.6 bits (174), Expect = 4e-12
Identities = 54/139 (38%), Positives = 69/139 (49%), Gaps = 18/139 (12%)
Query: 977 SRQACNSQSCPPA-WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPK 1035
S Q PPA W AG W CS +CG G +KRAV C+ SA + +P C + +
Sbjct: 829 SNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRG---SAGQRTVP--ACDAAHR 883
Query: 1036 PRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKC 1095
P +AC + C W +SAWS CS +C RG Q+R LKC V R LA +C
Sbjct: 884 PVETQAC-GEPCP-----TWELSAWSPCSKSCGRGFQRRSLKC----VGHGGRLLARDQC 933
Query: 1096 SHLPKPSLELERACAPLPC 1114
+ KP EL+ C PC
Sbjct: 934 NLHRKPQ-ELD-FCVLRPC 950
Score = 63.9 bits (154), Expect = 9e-10
Identities = 42/130 (32%), Positives = 58/130 (44%), Gaps = 24/130 (18%)
Query: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
+W+ +W CS +C G QKR + C S R + + +H P + +AC P
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDCRG---SAGQRTVPACDAAHRPVET----QACGE-P 893
Query: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLA-GGR--PASGCLLHQKPS 1170
CP +W S WS C+ SCG G Q RS++C+ GGR C LH+KP
Sbjct: 894 CP-------------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQ 940
Query: 1171 ASLACNTHFC 1180
C C
Sbjct: 941 ELDFCVLRPC 950
Score = 34.3 bits (77), Expect = 0.75
Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 11/68 (16%)
Query: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHFCP 1181
GSW P+ C+ +CGGGVQ QC GG+ G + + +CN CP
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYR-----SCNLEPCP 571
Query: 1182 IAEKKDAF 1189
+ +F
Sbjct: 572 SSASGKSF 579
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 397 bits (1021), Expect = e-110
Identities = 303/1019 (29%), Positives = 436/1019 (42%), Gaps = 164/1019 (16%)
Query: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
L++E LV V + Q H E+ YVLT LN+ + L +D ++G + +V +++L + +
Sbjct: 80 LHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPE 138
Query: 350 PGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCD----TLGFA 405
I+ + +L S C W + +D T HA L+ L I + E D G
Sbjct: 139 GAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLV--LYITRFDLELPDGNRQVRGVT 196
Query: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGE-GNMCKKSEGNIMSPTLAG 464
+ G CS SC I EDTG L TIAHE GH+FG+ HDG G+ C S G++M+ A
Sbjct: 197 QLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-GHVMASDGAA 255
Query: 465 RNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPV--KEYKYPEKLPGELYDANTQCKWQF 522
+WSPCSR+ L LS +A C+ D P+P P+ PG Y AN QC+ F
Sbjct: 256 PRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAF 315
Query: 523 GEKAKLCMLDFKK-DICKALWCHRIG---RKCETKFMPAAEGTICGHDMWCRGGQCVKYG 578
G KA C + D+C+AL CH C +P +GT CG + WC G+C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLV 375
Query: 579 DEGP-KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNS 637
+ P HG WS W SPCSR+CGGGV R R C NP+P+ GG+ C G+ ++CN+
Sbjct: 376 ELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNT 435
Query: 638 QKCPRDSVDFRAAQCAEHNSRRFRGR-----HYKWKPYTQVEDQD-LCKLYCIAEGFDFF 691
Q C + ++F + QCA + + R Y W D LC+ C A G F
Sbjct: 436 QACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFI 495
Query: 692 FSLSNKVKDGTPC------SEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSAC 745
+ DGT C + + ++C+ G C GCD + S V D C VC G+NS C
Sbjct: 496 MKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 555
Query: 746 TIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDW 805
+ +G +T +Y +T+ S+ I ++++VR RY + G ++
Sbjct: 556 SPRKGSFTAGR-AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG-GRYVVAGKMSISP 613
Query: 806 PGRYK--FSGTTFDYRRSYNEP-----ENLIATGPTNETLIVELLFQ-GRNPGVAWEYSM 857
Y +YR + E E + GP E +++ + G G +
Sbjct: 614 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG---NLTR 670
Query: 858 PRLG-TEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRP 915
P + T QP + ++ WA VR CSVSCG G V C + + V C +P
Sbjct: 671 PDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP 730
Query: 916 VTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC----- 970
C + CPP W+VG++ CS +CGGG + RPV+C + +P + C
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 790
Query: 971 ----------PQPAPS-------------------------------------------- 976
PQP P+
Sbjct: 791 QPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVD 850
Query: 977 ----SRQACNSQSCPPAW------SAG-----PWAE-----------------CSHTCGK 1004
+ + C SCPP W SAG PW CS +CG+
Sbjct: 851 EKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR 910
Query: 1005 GWRKRAVACKSTNPSARAQLLPDAVCTSEPKP-RMHEACLLQRCHKPKKLQWLVSAWSQC 1063
G + C SA + + +C KP E C C P + Q+ ++A C
Sbjct: 911 GLMELRFLCMD---SALRVPVQEELCGLASKPGSRREVCQAVPC--PARWQYKLAA---C 962
Query: 1064 SVTCERGTQKRFLKCAEKYVSGKYRE-LASKKCSHLPKPSLELERACAPLPCPRHPPFAA 1122
SV+C RG +R L CA + E L +C LP+P E + AC+ PCP +
Sbjct: 963 SVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP--EPQEACSLEPCPPRWKVMS 1020
Query: 1123 AGPSRGSWFASPWSQCTASCGGGVQTRSVQC--LAGGRPA----SGCLLHQKPSASLAC 1175
GP C+ASCG G RSV C L G+ + C +P AS+ C
Sbjct: 1021 LGP------------CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1067
Score = 122 bits (305), Expect = 3e-27
Identities = 77/252 (30%), Positives = 110/252 (43%), Gaps = 17/252 (6%)
Query: 868 AQPSYTWAIVRSECSVSCGGGQMTVREGCYRD-LKFQVNMSFCNPKTRPVTGLVPCKVSA 926
AQ ++ W CSVSCG G M +R C L+ V C ++P + C+
Sbjct: 891 AQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVP 950
Query: 927 CPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ----PAPSSRQACN 982
CP W +ACS +CG G R + C R H + + L Q P P ++AC+
Sbjct: 951 CPARWQY-KLAACSVSCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACS 1008
Query: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
+ CPP W CS +CG G +R+VAC + + + +A C + +P C
Sbjct: 1009 LEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVE-VDEAACAALVRPEASVPC 1067
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
L+ C +W V W +CSV+C G Q+R C + + C HLPKP
Sbjct: 1068 LIADC----TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---PVPADFCQHLPKP- 1119
Query: 1103 LELERACAPLPC 1114
R C PC
Sbjct: 1120 -VTVRGCWAGPC 1130
Score = 45.4 bits (106), Expect = 3e-04
Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 32/145 (22%)
Query: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERA 1108
KP++ + CSV+C G + C ++ + + + +C +P E A
Sbjct: 681 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPE-A 736
Query: 1109 CAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLH-- 1166
C PCP + W + C+ASCGGG++ R V+C+ A G LL
Sbjct: 737 CVLEPCPPY------------WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTL 780
Query: 1167 ---------QKPSASL-ACNTHFCP 1181
Q+P+ +L CN CP
Sbjct: 781 PPARCRAGAQQPAVALETCNPQPCP 805
Score = 42.0 bits (97), Expect = 0.004
Identities = 98/379 (25%), Positives = 138/379 (36%), Gaps = 78/379 (20%)
Query: 834 TNETLIVELLFQGRNP--GVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMT 891
TN + ELL R+P G + + ++ +P P+ T + S SV CG Q
Sbjct: 106 TNLNIGAELL---RDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSV-CGWSQTI 161
Query: 892 VREGC----YRDL-----KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRT 942
E + DL +F + + N + R VT L AC P+WS C T
Sbjct: 162 NPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLG----GACSPTWS------CLIT 211
Query: 943 CGGGAQSRPVQCTRRVH---YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECS 999
G H + + P S C PS + + P A A W+ CS
Sbjct: 212 EDTGFDLGVTIAHEIGHSFGLEHDGAPGSGC---GPSGHVMASDGAAPRAGLA--WSPCS 266
Query: 1000 HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV-S 1058
R++ ++ S + RA+ + D P+P+ A H P L S
Sbjct: 267 -------RRQLLSLLS---AGRARCVWDP-----PRPQPGSAG-----HPPDAQPGLYYS 306
Query: 1059 AWSQCSVTCERGTQKRFLKCAEKYV------SGKYRELASKKCSHLPKPSLE-----LER 1107
A QC V G + A +++ S L CS L P L+ +E+
Sbjct: 307 ANEQCRVAF--GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPAS 1161
C+ C G W + P S C+ SCGGGV TR QC GGR
Sbjct: 365 WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACV 424
Query: 1162 GCLLHQKPSASLACNTHFC 1180
G L + CNT C
Sbjct: 425 GADLQAE-----MCNTQAC 438
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 397 bits (1021), Expect = e-110
Identities = 303/1019 (29%), Positives = 436/1019 (42%), Gaps = 164/1019 (16%)
Query: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
L++E LV V + Q H E+ YVLT LN+ + L +D ++G + +V +++L + +
Sbjct: 80 LHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPE 138
Query: 350 PGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCD----TLGFA 405
I+ + +L S C W + +D T HA L+ L I + E D G
Sbjct: 139 GAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLV--LYITRFDLELPDGNRQVRGVT 196
Query: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGE-GNMCKKSEGNIMSPTLAG 464
+ G CS SC I EDTG L TIAHE GH+FG+ HDG G+ C S G++M+ A
Sbjct: 197 QLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-GHVMASDGAA 255
Query: 465 RNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPV--KEYKYPEKLPGELYDANTQCKWQF 522
+WSPCSR+ L LS +A C+ D P+P P+ PG Y AN QC+ F
Sbjct: 256 PRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAF 315
Query: 523 GEKAKLCMLDFKK-DICKALWCHRIG---RKCETKFMPAAEGTICGHDMWCRGGQCVKYG 578
G KA C + D+C+AL CH C +P +GT CG + WC G+C
Sbjct: 316 GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLV 375
Query: 579 DEGP-KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNS 637
+ P HG WS W SPCSR+CGGGV R R C NP+P+ GG+ C G+ ++CN+
Sbjct: 376 ELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNT 435
Query: 638 QKCPRDSVDFRAAQCAEHNSRRFRGR-----HYKWKPYTQVEDQD-LCKLYCIAEGFDFF 691
Q C + ++F + QCA + + R Y W D LC+ C A G F
Sbjct: 436 QACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFI 495
Query: 692 FSLSNKVKDGTPC------SEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSAC 745
+ DGT C + + ++C+ G C GCD + S V D C VC G+NS C
Sbjct: 496 MKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 555
Query: 746 TIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDW 805
+ +G +T +Y +T+ S+ I ++++VR RY + G ++
Sbjct: 556 SPRKGSFTAGR-AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG-GRYVVAGKMSISP 613
Query: 806 PGRYK--FSGTTFDYRRSYNEP-----ENLIATGPTNETLIVELLFQ-GRNPGVAWEYSM 857
Y +YR + E E + GP E +++ + G G +
Sbjct: 614 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG---NLTR 670
Query: 858 PRLG-TEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRP 915
P + T QP + ++ WA VR CSVSCG G V C + + V C +P
Sbjct: 671 PDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP 730
Query: 916 VTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC----- 970
C + CPP W+VG++ CS +CGGG + RPV+C + +P + C
Sbjct: 731 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 790
Query: 971 ----------PQPAPS-------------------------------------------- 976
PQP P+
Sbjct: 791 QPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVD 850
Query: 977 ----SRQACNSQSCPPAW------SAG-----PW-----------------AECSHTCGK 1004
+ + C SCPP W SAG PW CS +CG+
Sbjct: 851 EKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR 910
Query: 1005 GWRKRAVACKSTNPSARAQLLPDAVCTSEPKP-RMHEACLLQRCHKPKKLQWLVSAWSQC 1063
G + C SA + + +C KP E C C P + Q+ ++A C
Sbjct: 911 GLMELRFLCMD---SALRVPVQEELCGLASKPGSRREVCQAVPC--PARWQYKLAA---C 962
Query: 1064 SVTCERGTQKRFLKCAEKYVSGKYRE-LASKKCSHLPKPSLELERACAPLPCPRHPPFAA 1122
SV+C RG +R L CA + E L +C LP+P E + AC+ PCP +
Sbjct: 963 SVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP--EPQEACSLEPCPPRWKVMS 1020
Query: 1123 AGPSRGSWFASPWSQCTASCGGGVQTRSVQC--LAGGRPA----SGCLLHQKPSASLAC 1175
GP C+ASCG G RSV C L G+ + C +P AS+ C
Sbjct: 1021 LGP------------CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1067
Score = 123 bits (308), Expect = 1e-27
Identities = 95/318 (29%), Positives = 130/318 (40%), Gaps = 41/318 (12%)
Query: 868 AQPSYTWAIVRSECSVSCGGGQMTVREGCYRD-LKFQVNMSFCNPKTRPVTGLVPCKVSA 926
AQ ++ W CSVSCG G M +R C L+ V C ++P + C+
Sbjct: 891 AQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVP 950
Query: 927 CPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ----PAPSSRQACN 982
CP W +ACS +CG G R + C R H + + L Q P P ++AC+
Sbjct: 951 CPARWQY-KLAACSVSCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACS 1008
Query: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
+ CPP W CS +CG G +R+VAC + + + +A C + +P C
Sbjct: 1009 LEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVE-VDEAACAALVRPEASVPC 1067
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
L+ C +W V W +CSV+C G Q+R C + + C HLPKP
Sbjct: 1068 LIADC----TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---PVPADFCQHLPKP- 1119
Query: 1103 LELERACAPLPCPRH------PPFAAAGPSRGSWFASP------WSQCTASCGG------ 1144
R C PC P AA P R + A+P WSQ
Sbjct: 1120 -VTVRGCWAGPCVGQGTPSLVPHEEAAAPGRTT--ATPAGASLEWSQARGLLFSPAPQPR 1176
Query: 1145 ----GVQTRSVQCLAGGR 1158
G Q SVQ A GR
Sbjct: 1177 RLLPGPQENSVQSSACGR 1194
Score = 45.4 bits (106), Expect = 3e-04
Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 32/145 (22%)
Query: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERA 1108
KP++ + CSV+C G + C ++ + + + +C +P E A
Sbjct: 681 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPE-A 736
Query: 1109 CAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLH-- 1166
C PCP + W + C+ASCGGG++ R V+C+ A G LL
Sbjct: 737 CVLEPCPPY------------WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTL 780
Query: 1167 ---------QKPSASL-ACNTHFCP 1181
Q+P+ +L CN CP
Sbjct: 781 PPARCRAGAQQPAVALETCNPQPCP 805
Score = 42.0 bits (97), Expect = 0.004
Identities = 98/379 (25%), Positives = 138/379 (36%), Gaps = 78/379 (20%)
Query: 834 TNETLIVELLFQGRNP--GVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMT 891
TN + ELL R+P G + + ++ +P P+ T + S SV CG Q
Sbjct: 106 TNLNIGAELL---RDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSV-CGWSQTI 161
Query: 892 VREGC----YRDL-----KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRT 942
E + DL +F + + N + R VT L AC P+WS C T
Sbjct: 162 NPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLG----GACSPTWS------CLIT 211
Query: 943 CGGGAQSRPVQCTRRVH---YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECS 999
G H + + P S C PS + + P A A W+ CS
Sbjct: 212 EDTGFDLGVTIAHEIGHSFGLEHDGAPGSGC---GPSGHVMASDGAAPRAGLA--WSPCS 266
Query: 1000 HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV-S 1058
R++ ++ S + RA+ + D P+P+ A H P L S
Sbjct: 267 -------RRQLLSLLS---AGRARCVWDP-----PRPQPGSAG-----HPPDAQPGLYYS 306
Query: 1059 AWSQCSVTCERGTQKRFLKCAEKYV------SGKYRELASKKCSHLPKPSLE-----LER 1107
A QC V G + A +++ S L CS L P L+ +E+
Sbjct: 307 ANEQCRVAF--GPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 1108 ACAPLPCPRHPPFAAAGPSRGSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPAS 1161
C+ C G W + P S C+ SCGGGV TR QC GGR
Sbjct: 365 WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACV 424
Query: 1162 GCLLHQKPSASLACNTHFC 1180
G L + CNT C
Sbjct: 425 GADLQAE-----MCNTQAC 438
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 392 bits (1008), Expect = e-109
Identities = 308/1016 (30%), Positives = 437/1016 (43%), Gaps = 134/1016 (13%)
Query: 15 WMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDY 74
W L A + P A+GPAA + P A +GE EV R +
Sbjct: 5 WASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGE-------EVQERAEP 57
Query: 75 VSHEIMHHQRRRRAVPVSEVESLH--------LRLKGSRHDFHMDLRTSSSLVAPGFIVQ 126
H QRRR V ++ L+ L G R F +DL S+ GF+
Sbjct: 58 PGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRR-FLLDLERDGSVGIAGFV-- 114
Query: 127 TLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSH 186
G + CFY+G++ S C GL G + A Y L+PL
Sbjct: 115 ---PAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRG 171
Query: 187 LSW---KLGRA-AQGSSPSHVLYKR---STEPHAPGASEVLVTSRTWELAHQPLHSSDLR 239
W + GR GS+ +Y R S E P AS S H P HS+
Sbjct: 172 -PWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSG 230
Query: 240 LGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVD 299
Q + P P + R +RS+ R+ + VE L+V D
Sbjct: 231 RAALASQLL--DQSALSPAGGSG-----PQTWWR--RRRRSISRARQ-----VELLLVAD 276
Query: 300 KKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHAD 359
M + +G + Y+LT+ ++ + L+ +I +I +A+V +++L D+ L +S +A
Sbjct: 277 ASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAA 335
Query: 360 HTLSSFCQWQS--GLMGKDGTRH-DHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRS 416
TL +FC+WQ +G D H D AIL T D+C + CDTLG A + +CS RS
Sbjct: 336 TTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG--HHSCDTLGMADVGTICSPERS 393
Query: 417 CTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGN-----IMSPTLAGRNGVFSW 471
C + ED GL AFT+AHE GH G+ HD + C+++ G+ +MS L + W
Sbjct: 394 CAVIEDDGLHAAFTVAHEIGHLLGLSHD-DSKFCEETFGSTEDKRLMSSILTSIDASKPW 452
Query: 472 SPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCML 531
S C+ + +FL CL D P+ K+ PE+LPG+ YDA QC FG + +C
Sbjct: 453 SKCTSATITEFLDDGHGNCLLDLPR--KQILGPEELPGQTYDATQQCNLTFGPEYSVCP- 509
Query: 532 DFKKDICKALWCHRIGRK---CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPT--H 586
D+C LWC + + C TK +PA EGT CG C G+CV + T H
Sbjct: 510 --GMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSH 567
Query: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
G+W W SW CSR+CGGGV R C NP P + G++C G + C+ CP +
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKS 627
Query: 647 FRAAQCAEHNSRRFRGRHYK----WKP-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDG 701
FR QC N + + K W P Y V D+CKL C A+G ++ S KV DG
Sbjct: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDG 687
Query: 702 TPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQY 761
T C S +VC+ G C R GCD ++GS D CGVC G+NS+CT G + K + Y
Sbjct: 688 TECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGY 745
Query: 762 YHMVTIPSGARSIRIYEMNVS-----TSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTT 815
+V IP GA I++ + T+Y++++ Y +NG + + +GT
Sbjct: 746 TDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTV 805
Query: 816 FDYRRSYNEPENLIATG--PTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYT 873
+Y + + L G T E LIV++ L T+ P Y+
Sbjct: 806 MNYSGWSHRDDFLHGMGYSATKEILIVQI-----------------LATDPTKPLDVRYS 848
Query: 874 WAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSA--CPPSW 931
+ + + PK VT KV + P W
Sbjct: 849 FFVPKKS-----------------------------TPKVNSVTSHGSNKVGSHTSQPQW 879
Query: 932 SVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSC 986
G W ACSRTC G +R VQC D A CP PS+ + C + C
Sbjct: 880 VTGPWLACSRTCDTGWHTRTVQC-----QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 50.4 bits (119), Expect = 1e-05
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 6/65 (9%)
Query: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
S + P W GPW CS TC GW R V C+ N C +P + C
Sbjct: 872 SHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG------CPLSQRPSAFKQC 925
Query: 1043 LLQRC 1047
LL++C
Sbjct: 926 LLKKC 930
Score = 49.3 bits (116), Expect = 2e-05
Identities = 24/56 (42%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 1126 SRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP-ASGCLLHQKPSASLACNTHFC 1180
S+ W PW C+ +C G TR+VQC G R A GC L Q+PSA C C
Sbjct: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 34.3 bits (77), Expect = 0.75
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 1128 GSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCP 1181
GSW W QC+ SCGGGVQ C +G K + +C+ CP
Sbjct: 571 GSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
Score = 33.9 bits (76), Expect = 0.98
Identities = 29/104 (27%), Positives = 39/104 (37%), Gaps = 13/104 (12%)
Query: 930 SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPAS---LCPQPAPSSRQACNSQSC 986
SW G+W CSR+CGGG Q C + P P + C R +C+ C
Sbjct: 572 SW--GSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCTGKRAIYR-SCSLMPC 621
Query: 987 PPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVC 1030
PP + +C G + V A +LP VC
Sbjct: 622 PPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVC 665
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 372 bits (955), Expect = e-102
Identities = 278/926 (30%), Positives = 417/926 (45%), Gaps = 125/926 (13%)
Query: 97 LHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRN 156
L L L F + L S +AP F ++ LG +G + CF+ G++
Sbjct: 53 LALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRG-CFFSGTVNGEPE 111
Query: 157 SSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPH---- 212
S A+S C+GLSG + ++ ++P QG+ S +PH
Sbjct: 112 SLAAVSLCRGLSGSFLLDGEEFTIQP-------------QGAGGS------LAQPHRLQR 152
Query: 213 -APGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFIL---P 268
P + L WE+ G Q+Q ++ + +E+ P
Sbjct: 153 WGPAGARPLPRGPEWEV----------ETGEGQRQERGDHQEDSEEESQEEEAEGASEPP 202
Query: 269 DEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKD 328
+ R KR + +E VETL+V D M +G + + ++LT++++ + ++K
Sbjct: 203 PPLGATSRTKRFV-----SEARFVETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKH 256
Query: 329 GTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH----DHAI 384
+I +IN+ +V ++++EDE+ G +S + TL +FC WQ + RH D AI
Sbjct: 257 PSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF-NQPSDRHPEHYDTAI 315
Query: 385 LLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHD 444
LLT + C + CDTLG A I +C +SC++ ED GL A T+AHE GH M HD
Sbjct: 316 LLTRQNFCGQEGL-CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHD 374
Query: 445 GEGNMCKKSEG-----NIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVK 499
+ C + G ++M+P N WSPCS YL + L CL D P
Sbjct: 375 -DSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA- 432
Query: 500 EYKYPEKLPGE--LYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK--CETK-- 553
P LPG LY + QC+ FG + C +D+C LWCH G + C TK
Sbjct: 433 -LPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNG 491
Query: 554 FMPAAEGTICGHDMWCRGGQCVKYGD-EGPKPT-HGHWSDWSSWSPCSRTCGGGVSHRSR 611
+P A+GT CG C G C+ + E PKP G W+ W W CSRTCGGGV R
Sbjct: 492 SLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHR 551
Query: 612 LCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFR---GRHYKWK 668
C +P+P +GG++C G + C++++CP D FR QC ++N+ + G +W
Sbjct: 552 ECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWV 611
Query: 669 P-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLG 727
P Y V +D CKL+C A G F KV DGT C ++ +C+ G C + GCD+V+
Sbjct: 612 PKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVD 671
Query: 728 SDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYE-----MNVS 782
S D CGVC G ++C G T ++ Y +VTIP+GA +I + + +
Sbjct: 672 SPRKLDKCGVCGGKGNSCRKVSGSLTPTNYG--YNDIVTIPAGATNIDVKQRSHPGVQND 729
Query: 783 TSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVE 841
+Y++++ A +Y LNG+ + + GT Y S E L + P E L V+
Sbjct: 730 GNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQ 789
Query: 842 LLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLK 901
LL PG + P + YT+ +
Sbjct: 790 LLTV---PGEVF-------------PPKVKYTFFVPND---------------------- 811
Query: 902 FQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYD 961
V+ S + K R T ++ + A W +G+WS CS TCG G Q R V+C
Sbjct: 812 --VDFSMQSSKERATTNIIQPLLHA---QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA 866
Query: 962 SEPVPASLCPQPAPSSRQACNSQSCP 987
S +L P+ A + C SQ CP
Sbjct: 867 SATCNKALKPEDA----KPCESQLCP 888
Score = 51.2 bits (121), Expect = 6e-06
Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 6/58 (10%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
W G W+ECS TCG GW++R V C+ +PS +A A C KP + C Q C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECR--DPSGQA----SATCNKALKPEDAKPCESQLC 887
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 1130 WFASPWSQCTASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCPI 1182
W WS+C+++CG G Q R+V+C G+ ++ C KP + C + CP+
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL 889
Score = 41.2 bits (95), Expect = 0.006
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 934 GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP 988
G W CSRTCGGG Q +C D EP + Q+C+++ CPP
Sbjct: 533 GPWGECSRTCGGGVQFSHRECK-----DPEPQNGGRYCLGRRAKYQSCHTEECPP 582
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 8/62 (12%)
Query: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
QW++ WS+CS TC G Q+R ++C + SG+ AS C+ KP E + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDP--SGQ----ASATCNKALKP--EDAKPCESQL 886
Query: 1114 CP 1115
CP
Sbjct: 887 CP 888
Score = 36.2 bits (82), Expect = 0.20
Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 3/74 (4%)
Query: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEK- 1185
G W PW +C+ +CGGGVQ +C G + + +C+T CP K
Sbjct: 527 GGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKS 586
Query: 1186 -KDAFCKDYFHWCY 1198
++ C+ Y + Y
Sbjct: 587 FREQQCEKYNAYNY 600
Score = 35.4 bits (80), Expect = 0.34
Identities = 29/113 (25%), Positives = 40/113 (35%), Gaps = 20/113 (17%)
Query: 993 GPWAECSHTCGKGWRKRAVACKSTNPS-----ARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
GPW ECS TCG G + CK P + C +E P ++ Q+C
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQC 592
Query: 1048 HK----------PKKLQWL-----VSAWSQCSVTCERGTQKRFLKCAEKYVSG 1085
K LQW+ VS +C + C + F K + G
Sbjct: 593 EKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 371 bits (952), Expect = e-102
Identities = 294/1017 (28%), Positives = 423/1017 (41%), Gaps = 191/1017 (18%)
Query: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
L++E LV V + Q H E+ YVLT LN+ + L +D ++G + +V +++L + +
Sbjct: 80 LHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPE 138
Query: 350 PGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCD----TLGFA 405
I+ + +L S C W + +D T HA L+ L I + E D G
Sbjct: 139 GAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLV--LYITRFDLELPDGNRQVRGVT 196
Query: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGE-GNMCKKSEGNIMSPTLAG 464
+ G CS SC I EDTG L TIAHE GH+FG+ HDG G+ C S G++M+ A
Sbjct: 197 QLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-GHVMASDGAA 255
Query: 465 RNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGE 524
+WSPCSR+ L LS AN QC+ FG
Sbjct: 256 PRAGLAWSPCSRRQLLSLLS-----------------------------ANEQCRVAFGP 286
Query: 525 KAKLCMLDFKK-DICKALWCHRIG---RKCETKFMPAAEGTICGHDMWCRGGQCVKYGDE 580
KA C + D+C+AL CH C +P +GT CG + WC G+C +
Sbjct: 287 KAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVEL 346
Query: 581 GP-KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
P HG WS W SPCSR+CGGGV R R C NP+P+ GG+ C G+ ++CN+Q
Sbjct: 347 TPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQA 406
Query: 640 CPRDSVDFRAAQCAEHNSRRFRGR-----HYKWKPYTQVEDQD-LCKLYCIAEGFDFFFS 693
C + ++F + QCA + + R Y W D LC+ C A G F
Sbjct: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 466
Query: 694 LSNKVKDGTPC------SEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTI 747
+ DGT C + + ++C+ G C GCD + S V D C VC G+NS C+
Sbjct: 467 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSP 526
Query: 748 HRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPG 807
+G +T +Y +T+ S+ I ++++VR RY + G ++
Sbjct: 527 RKGSFTAGR-AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG-GRYVVAGKMSISPNT 584
Query: 808 RYK--FSGTTFDYRRSYNEP-----ENLIATGPTNETLIVELLFQ-GRNPGVAWEYSMPR 859
Y +YR + E E + GP E +++ + G G + P
Sbjct: 585 TYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG---NLTRPD 641
Query: 860 LG-TEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRPVT 917
+ T QP + ++ WA VR CSVSCG G V C + + V C +P
Sbjct: 642 ITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPA 701
Query: 918 GLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC------- 970
C + CPP W+VG++ CS +CGGG + RPV+C + +P + C
Sbjct: 702 WPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQP 761
Query: 971 --------PQPAPS---------------------------------------------- 976
PQP P+
Sbjct: 762 AVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEK 821
Query: 977 --SRQACNSQSCPPAW------SAG-----PWAE-----------------CSHTCGKGW 1006
+ + C SCPP W SAG PW CS +CG+G
Sbjct: 822 LPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGL 881
Query: 1007 RKRAVACKSTNPSARAQLLPDAVCTSEPKP-RMHEACLLQRCHKPKKLQWLVSAWSQCSV 1065
+ C SA + + +C KP E C C P + Q+ ++A CSV
Sbjct: 882 MELRFLCMD---SALRVPVQEELCGLASKPGSRREVCQAVPC--PARWQYKLAA---CSV 933
Query: 1066 TCERGTQKRFLKCAEKYVSGKYRE-LASKKCSHLPKPSLELERACAPLPCPRHPPFAAAG 1124
+C RG +R L CA + E L +C LP+P E + AC+ PCP + G
Sbjct: 934 SCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP--EPQEACSLEPCPPRWKVMSLG 991
Query: 1125 PSRGSWFASPWSQCTASCGGGVQTRSVQC--LAGGRPA----SGCLLHQKPSASLAC 1175
P C+ASCG G RSV C L G+ + C +P AS+ C
Sbjct: 992 P------------CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1036
Score = 122 bits (305), Expect = 3e-27
Identities = 77/252 (30%), Positives = 110/252 (43%), Gaps = 17/252 (6%)
Query: 868 AQPSYTWAIVRSECSVSCGGGQMTVREGCYRD-LKFQVNMSFCNPKTRPVTGLVPCKVSA 926
AQ ++ W CSVSCG G M +R C L+ V C ++P + C+
Sbjct: 860 AQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVP 919
Query: 927 CPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ----PAPSSRQACN 982
CP W +ACS +CG G R + C R H + + L Q P P ++AC+
Sbjct: 920 CPARWQY-KLAACSVSCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACS 977
Query: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
+ CPP W CS +CG G +R+VAC + + + +A C + +P C
Sbjct: 978 LEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVE-VDEAACAALVRPEASVPC 1036
Query: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
L+ C +W V W +CSV+C G Q+R C + + C HLPKP
Sbjct: 1037 LIADC----TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---PVPADFCQHLPKP- 1088
Query: 1103 LELERACAPLPC 1114
R C PC
Sbjct: 1089 -VTVRGCWAGPC 1099
Score = 47.8 bits (112), Expect = 7e-05
Identities = 96/366 (26%), Positives = 131/366 (35%), Gaps = 83/366 (22%)
Query: 834 TNETLIVELLFQGRNP--GVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMT 891
TN + ELL R+P G + + ++ +P P+ T + S SV CG Q
Sbjct: 106 TNLNIGAELL---RDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSV-CGWSQTI 161
Query: 892 VREGC----YRDL-----KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRT 942
E + DL +F + + N + R VT L AC P+WS C T
Sbjct: 162 NPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLG----GACSPTWS------CLIT 211
Query: 943 CGGGAQSRPVQCTRRVH---YDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECS 999
G H + + P S C PS + + P A A W+ CS
Sbjct: 212 EDTGFDLGVTIAHEIGHSFGLEHDGAPGSGC---GPSGHVMASDGAAPRAGLA--WSPCS 266
Query: 1000 HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSA 1059
R++ ++ S N R P AV + + + + C CH Q S+
Sbjct: 267 -------RRQLLSLLSANEQCRVAFGPKAVACTFAREHL-DMCQALSCHTDPLDQ---SS 315
Query: 1060 WSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPP 1119
S+ V GT+ K K G+ R L +EL P
Sbjct: 316 CSRLLVPLLDGTECGVEKWCSK---GRCRSL------------VELT------------P 348
Query: 1120 FAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLA 1174
AA SW P S C+ SCGGGV TR QC GGR G L +
Sbjct: 349 IAAVHGRWSSW--GPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAE-----M 401
Query: 1175 CNTHFC 1180
CNT C
Sbjct: 402 CNTQAC 407
Score = 45.4 bits (106), Expect = 3e-04
Identities = 38/145 (26%), Positives = 60/145 (41%), Gaps = 32/145 (22%)
Query: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERA 1108
KP++ + CSV+C G + C ++ + + + +C +P E A
Sbjct: 650 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPE-A 705
Query: 1109 CAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLH-- 1166
C PCP + W + C+ASCGGG++ R V+C+ A G LL
Sbjct: 706 CVLEPCPPY------------WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTL 749
Query: 1167 ---------QKPSASL-ACNTHFCP 1181
Q+P+ +L CN CP
Sbjct: 750 PPARCRAGAQQPAVALETCNPQPCP 774
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 352 bits (902), Expect = 2e-96
Identities = 219/596 (36%), Positives = 297/596 (49%), Gaps = 47/596 (7%)
Query: 292 VETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPG 351
VETLVV D KM HG + Y+LT++ + FK +I +++ + L++L + G
Sbjct: 220 VETLVVADDKMAAFHG-AGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEG 278
Query: 352 LVISHHADHTLSSFCQWQSGLMGKDGTRHDH---AILLTGLDICSWKNEPCDTLGFAPIS 408
+ A TL SFC WQ GL + + DH AIL T D+C CDTLG A +
Sbjct: 279 PQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVST--CDTLGMADVG 336
Query: 409 GMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEG-----NMCKKSEGNIMSPTLA 463
+C RSC I ED GL AFT AHE GH F M+HD N + ++M+P +A
Sbjct: 337 TVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA 396
Query: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
+ WSPCS +++ FL CL D KP P PG+ YDA+ QC+ FG
Sbjct: 397 HVDPEEPWSPCSARFITDFLDNGYGHCLLD--KPEAPLHLPVTFPGKDYDADRQCQLTFG 454
Query: 524 EKAKLCMLDFKKDICKALWC--HRIGRK-CETKFMPAAEGTICGHDMWCRGGQCVKYGD- 579
++ C C ALWC H G C+TK P A+GT CG C GG+C+
Sbjct: 455 PDSRHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQL 512
Query: 580 -EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQ 638
+ P G W W W CSRTCGGGV SR CT P P +GGK+CEG + CN++
Sbjct: 513 QDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTE 572
Query: 639 KCPRDS-VDFRAAQCAEHNSRRFRGRHYK----WKP-YTQVEDQDLCKLYCIAEGFDFFF 692
CP S + FR QCA +N R + + W P YT V QD CKL C A+ +++
Sbjct: 573 DCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYY 632
Query: 693 SLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY 752
L +V DGTPCS DS +VC+ G C GCD ++GS D C VC G+ S C+ G +
Sbjct: 633 VLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSF 692
Query: 753 TKHHHTNQYYHMVTIPSGARSIRIYEM---NVSTSYISVRNALRRYYLNGHWT------- 802
K + Y ++VTIP+GA I + + + Y++++ Y LNG +T
Sbjct: 693 RKFRY--GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTD 750
Query: 803 VDWPG--RYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYS 856
V PG ++SG T E L GP + L +++L G YS
Sbjct: 751 VVLPGAVSLRYSGAT-------AASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYS 799
Score = 41.6 bits (96), Expect = 0.005
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 1125 PSRGSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIA 1183
P G W PW C+ +CGGGVQ S C G + + +CNT CP
Sbjct: 518 PQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTG 577
Query: 1184 EK---KDAFCKDYFH 1195
++ C Y H
Sbjct: 578 SALTFREEQCAAYNH 592
Score = 40.0 bits (92), Expect = 0.014
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 11/57 (19%)
Query: 934 GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVP---ASLCPQPAPSSRQACNSQSCP 987
G W CSRTCGGG Q CTR PVP C + + ++CN++ CP
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTR-------PVPRNGGKYC-EGRRTRFRSCNTEDCP 575
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 335 bits (860), Expect = 1e-91
Identities = 234/777 (30%), Positives = 332/777 (42%), Gaps = 146/777 (18%)
Query: 564 GHDMWCRGGQCVKYGDE-GPKPTH-GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
G W GG +G P P H G W S P H S L + PS
Sbjct: 313 GQGPWGTGG--TPHGPRLEPDPQHPGAWLPLLSNGP----------HASSLWSLFAPSSP 360
Query: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
C G + L+ C+ CP + D RA QCA NS+ F G+ Y+W+P+T+V+ C+L
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
C GF F+ + KV+DGT C + ++C+ G C GCD +LGS D CGVC G+
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
+S C + G T Y ++ IP+GA ++I ++ S++Y+++R R +NG+W
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 802 TVDWPGRYKFSGTTFDYRRSYNEP---ENLIATGPTNETLIVELLFQGRNPGVAWEY--- 855
VD PG Y+ GT F Y R E E+L A GPT + + V ++FQ NPGV ++Y
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 856 -------------SMPRLGTE---KQPPAQP----------------------------- 870
+P+L E +PP P
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 871 -----SYTWAIVRSECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKV 924
+Y + S CS SCG G C R+ +++ C RP PC
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 925 SACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQACNS 983
+ CPP W G W++CSR+CG G Q R +QC + VP C P P+ Q+C
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 984 QSCPPAWSAG-PWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
+ C W G PW++CS CG+G R R V C N ++ + P+P EAC
Sbjct: 781 RLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD---EVSEQECASGPPQPPSREAC 836
Query: 1043 LLQRCHKPKKLQWLVSAW-SQCSVTCERGTQKRFLKCAEKYVS-----GKYRELASKKCS 1096
+ C W S W S+CS C G Q+R + C + G+ + C
Sbjct: 837 DMGPC----TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
Query: 1097 HLPKPSLELERACAPLPCPR---------------------------------------- 1116
+P RAC+ PC R
Sbjct: 893 TGSRP--PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSP 950
Query: 1117 -------HPPFAAAGPSRGS-----WFASPWSQCTASCGGGVQTRSVQCLAGGRPAS-GC 1163
PP A P +G WF++PWS C+ SC GG QTR VQCL+ + S C
Sbjct: 951 SNCSHLPRPP--ALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRC 1008
Query: 1164 LLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCS 1220
+PS CN+ P +++ D CKD C LV Q +C + +Y CC++C+
Sbjct: 1009 PPQLRPSRKRPCNSQ--PCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCA 1063
Score = 42.4 bits (98), Expect = 0.003
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
+EG P G W W W+ CS+ CG GV RSR C P
Sbjct: 38 EEGQGP-EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 32.3 bits (72), Expect = 2.8
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQL-LPDAVCTSEPKPRMHEACLLQRCHKPK 1051
WA CS CG G ++R+ C+ L LP P+P H LL R P+
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLP-------PRPPRHPEALLPRGQGPR 103
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 328 bits (840), Expect = 3e-89
Identities = 202/566 (35%), Positives = 276/566 (48%), Gaps = 64/566 (11%)
Query: 589 WSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFR 648
W WS WSPCSRTCGGGVS R R C + + GG C G R+ + C ++ CP + DFR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 649 AAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDS 708
A QCAE + F+GR Y+W PY ++ C+L CI +G +F++ V DGTPC
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAPNK--CELNCIPKGENFYYKHREAVVDGTPCEPGK 145
Query: 709 RNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIP 768
R+VC+DG C VGCD+ L S ED C C G+ + C G + + +
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSR--------- 196
Query: 769 SGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYN---EP 825
+V+N YYLNGHWT++ + T Y R P
Sbjct: 197 ------------------AVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
Query: 826 ENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVR-SECSVS 884
E L A GPT+E L++EL+ Q NPGV +EY +P ++P P ++W+ S+CS
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPL----RRP--SPGFSWSHGSWSDCSAE 292
Query: 885 CGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS--WSVGNWSACSRT 942
CGGG + C D + + C + RP C + CP + W G W+ CS +
Sbjct: 293 CGGGHQSRLVFCTIDHEAYPD-HMCQRQPRPADRR-SCNLHPCPETKRWKAGPWAPCSAS 350
Query: 943 CGGGAQSRPVQCTRRVHYD-SEPVPASLCP--QPAPSSRQACNSQSCPPAWSAGPWAECS 999
CGGG+QSR V C E V + C P + QACN Q C AWS PW ECS
Sbjct: 351 CGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECS 409
Query: 1000 HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSA 1059
+CG G RKR+V C+ R LL A C+ E +P + E C+ + C W V
Sbjct: 410 VSCGVGVRKRSVTCRGE----RGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGT 465
Query: 1060 WSQCSVTCERGTQKRFLKCAEKYVS--GKYR-------ELASKKCSHLPK--PSLELERA 1108
W CS +C GT++R + CA S G + E + + HLP+ PS++
Sbjct: 466 WGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHT 525
Query: 1109 CAPLP-CPRHPPFAAAGPSRGSWFAS 1133
A P P P + A SRG W+A+
Sbjct: 526 PASNPWMPLGPQESPASDSRGQWWAA 551
Score = 156 bits (394), Expect = 1e-37
Identities = 101/286 (35%), Positives = 130/286 (45%), Gaps = 31/286 (10%)
Query: 930 SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSCPP 988
SWS G+WS CS CGGG QSR V CT D E P +C QP P+ R++CN CP
Sbjct: 280 SWSHGSWSDCSAECGGGHQSRLVFCT----IDHEAYPDHMCQRQPRPADRRSCNLHPCPE 335
Query: 989 A--WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEP-KPRMHEACLLQ 1045
W AGPWA CS +CG G + R+V C S++ + + + +A C P KP +AC LQ
Sbjct: 336 TKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ 395
Query: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
RC W W +CSV+C G +KR + C + S L + CS +P L
Sbjct: 396 RC-----AAWSPEPWGECSVSCGVGVRKRSVTCRGERGS----LLHTAACSLEDRPPLT- 445
Query: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLL 1165
C CP S +W W C+ SC G + R V C G G L
Sbjct: 446 -EPCVHEDCPLL--------SDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQ 496
Query: 1166 HQKPSASLACNTHFCPIAEK----KDAFCKDYFHWCYLVPQHGMCS 1207
H KP CNT C + ++ +D W L PQ S
Sbjct: 497 HSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESPAS 542
Score = 72.0 bits (175), Expect = 3e-12
Identities = 48/158 (30%), Positives = 62/158 (39%), Gaps = 25/158 (15%)
Query: 1031 TSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYREL 1090
+ EP P +H L W +WS CS C G Q R + C + +
Sbjct: 257 SQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEA-----Y 311
Query: 1091 ASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRS 1150
C P+P+ R+C PCP W A PW+ C+ASCGGG Q+RS
Sbjct: 312 PDHMCQRQPRPADR--RSCNLHPCPETK----------RWKAGPWAPCSASCGGGSQSRS 359
Query: 1151 VQCLAGG--------RPASGCLLHQKPSASLACNTHFC 1180
V C++ A L KP A ACN C
Sbjct: 360 VYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Score = 44.7 bits (104), Expect = 6e-04
Identities = 28/74 (37%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 915 PVTGLVPCKVSACPPSWSV-GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQP 973
P G KV +W WS CSRTCGGG R C Y S C P
Sbjct: 13 PAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPC-----YSQRRDGGSSCVGP 67
Query: 974 APSSRQACNSQSCP 987
A S R +C ++SCP
Sbjct: 68 ARSHR-SCRTESCP 80
Score = 39.7 bits (91), Expect = 0.018
Identities = 25/73 (34%), Positives = 31/73 (42%), Gaps = 5/73 (6%)
Query: 1110 APLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP-ASGCLLHQK 1168
AP P P + G W S WS C+ +CGGGV R C + R S C+ +
Sbjct: 12 APAPGSSAPKVRRQSDTWGPW--SQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR 69
Query: 1169 PSASLACNTHFCP 1181
S C T CP
Sbjct: 70 SHRS--CRTESCP 80
Score = 39.3 bits (90), Expect = 0.023
Identities = 20/61 (32%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Query: 583 KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKC 640
+P+ G SWS CS CGGG R CT ++ C+ R + CN C
Sbjct: 274 RPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPC 333
Query: 641 P 641
P
Sbjct: 334 P 334
Score = 35.8 bits (81), Expect = 0.26
Identities = 33/142 (23%), Positives = 49/142 (34%), Gaps = 31/142 (21%)
Query: 965 VPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL 1024
VP L P P S+ + WS W+ CS TCG G R C S +
Sbjct: 7 VPLLLAPAPGSSAPKVRRQSDTWGPWSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGSSC 64
Query: 1025 LPDAVCTSEPKPRMHEACLLQRC-------------------HKPKKLQWL--VSAWSQC 1063
+ A R H +C + C + ++ +WL SA ++C
Sbjct: 65 VGPA--------RSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKC 116
Query: 1064 SVTCERGTQKRFLKCAEKYVSG 1085
+ C + + K E V G
Sbjct: 117 ELNCIPKGENFYYKHREAVVDG 138
Score = 35.0 bits (79), Expect = 0.44
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 15/70 (21%)
Query: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCE-----------GSTR 630
P P W W+PCS +CGGG RS C + S G E G
Sbjct: 332 PCPETKRWKA-GPWAPCSASCGGGSQSRSVYCIS---SDGAGIQEAVEEAECAGLPGKPP 387
Query: 631 TLKLCNSQKC 640
++ CN Q+C
Sbjct: 388 AIQACNLQRC 397
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 307 bits (786), Expect = 5e-83
Identities = 195/591 (32%), Positives = 287/591 (48%), Gaps = 66/591 (11%)
Query: 625 CEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCI 684
C G+ R KLCN+ CP S R QCA +N++ F GR Y+W+P+ +V+ C+L C
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
Query: 685 AEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSA 744
A G+ F+ + KV DGTPC ++ +C+ G C+ +GCD+ LGSD V D CGVC G+N+
Sbjct: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
Query: 745 CTIHRGLYTKHHHTNQYYH-MVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTV 803
C + G++ KH T+ YH +V IP GA I I EM S +Y+++R+ R +NG+W +
Sbjct: 411 CQVVSGVF-KHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAI 469
Query: 804 DWPGRYKFSGTTFDYRR----SYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPR 859
D PG+Y+ GT F Y+R S E+ +A GPTNE L V ++ Q NPGV +EY +
Sbjct: 470 DRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVI-- 527
Query: 860 LGTEKQPPAQPSYTWAIVRSECSVSCGG-----GQMTVREGCYRDLKFQVNMSFCNPKTR 914
+GT P P + + G G+ R DL+ + F + +
Sbjct: 528 MGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQ 587
Query: 915 PVTGLVPCKVSACPP-----------------SWSVGNWSACSRTCGGGAQSRPVQCTRR 957
P + S P +W + CS TCG G+Q +C R
Sbjct: 588 TFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR 647
Query: 958 VHYDSEPVPASLCP---QPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACK 1014
+ E P S C +P P + CN CP W G W+ECS TCG G + R V C+
Sbjct: 648 STH--EEAPESYCDSSMKPTP-EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCR 704
Query: 1015 STNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV-SAWSQCSVTCERGTQK 1073
+ + P C KP C L+ C +W + + W+ CSV C G +
Sbjct: 705 QVYANRSLTVQPYR-CQHLEKPETTSTCQLKICS-----EWQIRTDWTSCSVPCGVGQRT 758
Query: 1074 RFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFAS 1133
R +KC VS + ++C+ +P+ ++E C PC + SWF +
Sbjct: 759 RDVKC----VSNIGDVVDDEECNMKLRPN-DIEN-CDMGPCAK------------SWFLT 800
Query: 1134 PWSQ-CTASCGGGVQTRSVQCL---AGGRPASGCLLHQKPSASLACNTHFC 1180
WS+ C+A CG GV+TRSV C+ P GC + +P+ + C+ C
Sbjct: 801 EWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC-GNNRPAEATPCDNGPC 850
Score = 155 bits (393), Expect = 2e-37
Identities = 110/406 (27%), Positives = 160/406 (39%), Gaps = 59/406 (14%)
Query: 865 QPPAQP-SYTWA-IVRSECSVSCG-GGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVP 921
QPP + + W + +ECS +CG G Q + +R + S+C+ +P P
Sbjct: 611 QPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEP 670
Query: 922 CKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQA 980
C + CP W +G WS CS+TCG G Q R V C + S V C P +
Sbjct: 671 CNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTST 730
Query: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
C + C W CS CG G R R V C S ++ D C + +P E
Sbjct: 731 CQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSN----IGDVVDDEECNMKLRPNDIE 786
Query: 1041 ACLLQRCHKPKKLQWLVSAWSQ-CSVTCERGTQKRFLKCAEKYVS-------GKYRELAS 1092
C + C K W ++ WS+ CS C G + R + C +VS G R +
Sbjct: 787 NCDMGPCAK----SWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEA 842
Query: 1093 KKCSHLP-------------KPSLEL-----------------------ERACAPLPCPR 1116
C + P + S+E C+ L P
Sbjct: 843 TPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPP 902
Query: 1117 HPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG-CLLHQKPSASLAC 1175
P WF++ WS C+ SC GG + R V+CL+ S C KP +C
Sbjct: 903 SQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
Query: 1176 NTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
N C + D CKD ++ C +V Q +C + +Y CC +C++
Sbjct: 963 NPQDC--VPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
Score = 42.4 bits (98), Expect = 0.003
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLC 613
D+G G W W WS CSR+C GGV ++R C
Sbjct: 46 DDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 37.7 bits (86), Expect = 0.068
Identities = 19/57 (33%), Positives = 27/57 (47%), Gaps = 1/57 (1%)
Query: 1099 PKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA-SPWSQCTASCGGGVQTRSVQCL 1154
P+PS + + + P G + G W A PWS C+ SC GGV ++ CL
Sbjct: 25 PQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCL 81
Score = 35.4 bits (80), Expect = 0.34
Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 1/30 (3%)
Query: 584 PTHGHWSDWSSWSPCSRTCGGGVSHRSRLC 613
P W D WS CS+TCG G+ HR LC
Sbjct: 675 PCPAFW-DIGEWSECSKTCGLGMQHRQVLC 703
Score = 32.3 bits (72), Expect = 2.8
Identities = 26/97 (26%), Positives = 36/97 (37%), Gaps = 25/97 (25%)
Query: 969 LCPQPAPSSRQACNSQSC------------PPAWSA-GPWAECSHTCGKGWRKRAVAC-- 1013
+CPQP+ R+ + P W A GPW+ CS +C G ++ C
Sbjct: 23 VCPQPSTQHRKVPQRMAAEGAPEDDGGGGAPGVWGAWGPWSACSRSCSGGVMEQTRPCLP 82
Query: 1014 ------KSTNPSARAQLLPD----AVCTSEPKPRMHE 1040
P A A+ D AV TS P R +
Sbjct: 83 RSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRD 119
Score = 32.3 bits (72), Expect = 2.8
Identities = 14/31 (45%), Positives = 16/31 (51%), Gaps = 1/31 (3%)
Query: 928 PPSWSV-GNWSACSRTCGGGAQSRPVQCTRR 957
P W G WSACSR+C GG + C R
Sbjct: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCLPR 83
Score = 31.2 bits (69), Expect = 6.3
Identities = 19/64 (29%), Positives = 24/64 (37%), Gaps = 5/64 (7%)
Query: 550 CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHR 609
C T + + CG++ C D GP W SWS CS CG G R
Sbjct: 821 CMTNHVSSLPLEGCGNNRPAEATPC----DNGPCTGKVEWFA-GSWSQCSIECGSGTQQR 875
Query: 610 SRLC 613
+C
Sbjct: 876 EVIC 879
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 282 bits (722), Expect = 1e-75
Identities = 211/678 (31%), Positives = 300/678 (44%), Gaps = 104/678 (15%)
Query: 576 KYGDEGPKPTH------GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGST 629
+Y D+ + T G+W W WS CSRTCGGG S+ R C G+ CEG
Sbjct: 59 RYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQN 112
Query: 630 RTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFD 689
K C++ CP D+ DFRA QC+ +N +++G +Y+W P + C L C A+G +
Sbjct: 113 IRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYN-DPAAPCALKCHAQGQN 171
Query: 690 FFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHR 749
L+ KV DGT C+ DS ++CI GIC+ VGCD LGS+A ED CGVC G+ S C + R
Sbjct: 172 LVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVR 231
Query: 750 GLYTKH-HHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGR 808
G H + +++ +P G+RS+RI + +I + G + + PG
Sbjct: 232 GQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGV 288
Query: 809 YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA 868
+ TT +++R +E + GP L+ + +F+ R Y+ + +
Sbjct: 289 FLVENTTVEFQRG-SERQTFKIPGP----LMADFIFKTR-------YTAAKDSVVQFFFY 336
Query: 869 QP-SYTWAIVR-SECSVSCGGG-QMTVREGCYRDLKFQVNMSFCN---PKTRPVTGLVPC 922
QP S+ W C+V+CGGG Q+ E LK V +C+ +P L C
Sbjct: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKEC 396
Query: 923 KVSACP-----------------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEP 964
+ CP P W W+ACS +CGGG Q R C +H +
Sbjct: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
Query: 965 VPASLCP-QPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQ 1023
V C P P Q CN C P W A W++C+ TCG+G R R V C + R +
Sbjct: 457 VEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLC----INHRGE 511
Query: 1024 LLPDAVCTSEPKPRMHEACLLQ-RCHKPK-------KLQWLVSA---------------- 1059
+ C + K + E C++ C+KPK KL WL A
Sbjct: 512 HV--GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFI 569
Query: 1060 ---WSQCSVTCERGTQKRFLKCAEKYV-SGKYRELASKKCSHLPKPSLELERACAPLPCP 1115
WS CS TC G Q R +KC + EL ++C P L ER C C
Sbjct: 570 PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECE---GPKLPTERPCLLEACD 626
Query: 1116 RHP-------PFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPA----SGC- 1163
P P + W + ++ CTA+C GG Q CL S C
Sbjct: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCD 686
Query: 1164 LLHQKPSASLACNTHFCP 1181
++H+ P+ S ACNT CP
Sbjct: 687 MVHRPPAMSQACNTEPCP 704
Score = 147 bits (370), Expect = 8e-35
Identities = 86/251 (34%), Positives = 110/251 (43%), Gaps = 12/251 (4%)
Query: 868 AQPSYTWAIVR-SECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRPVTGLVPCKVS 925
++ +Y W + C+ +C GG C Q VN S C+ RP C
Sbjct: 642 SETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE 701
Query: 926 ACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQS 985
CPP W VG+W CS TCG G Q+R V C +H P P C P + QACN
Sbjct: 702 PCPPRWHVGSWGPCSATCGVGIQTRDVYC---LHPGETPAPPEECRDEKPHALQACNQFD 758
Query: 986 CPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQ 1045
CPP W W +CS TCG G + R V C+ L D +C PK H++C
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG-PKASSHKSCART 817
Query: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
C P L V WS+CSV+C G Q+R C G+ L+ C L P L L
Sbjct: 818 DC--PPHL--AVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDL--PGLPL 871
Query: 1106 ERACAPLPCPR 1116
R+C C +
Sbjct: 872 VRSCQMPECSK 882
Score = 130 bits (327), Expect = 8e-30
Identities = 83/300 (27%), Positives = 132/300 (44%), Gaps = 42/300 (14%)
Query: 929 PSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLCP--QPAPSSRQACNSQS 985
P W GNWS CS TCG GA+ + QC V + + V +LC Q + + CN +
Sbjct: 1426 PFWEPGNWSHCSATCGHLGARIQRPQC---VMANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
Query: 986 CPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQ 1045
CP W W++CS +CG+G+ R V CK T + Q++ C + +P + C
Sbjct: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
Query: 1046 RCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
C +QW ++C C R ++ +++ + ++ + C +P+ L
Sbjct: 1543 PC-----VQW--EPGNRCPGRC----MGRAVRMQQRHTACQHNS-SDSNCDDRKRPT--L 1588
Query: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPAS-- 1161
R C +G W PW CTA+CG G Q+R V C+ +P +
Sbjct: 1589 RRNC------------TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKR 1636
Query: 1162 GCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
C+ +KP + C C D C D H+C V +CS Y ++CC++C +
Sbjct: 1637 HCVQKKKPISWRHCLGPSC------DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
Score = 124 bits (310), Expect = 7e-28
Identities = 97/333 (29%), Positives = 131/333 (39%), Gaps = 70/333 (21%)
Query: 852 AWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNP 911
A E R+ TE+ P W S CS +CG G R++K +V ++F
Sbjct: 553 AQELEETRIATEE--PTFIPEPW----SACSTTCGPGVQV------REVKCRVLLTFTQT 600
Query: 912 KTR---------PVTGLVPCKVSACPPS-------------------WSVGNWSACSRTC 943
+T + PC + AC S W ++ C+ TC
Sbjct: 601 ETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
Query: 944 GGGAQSRPVQCTRRVHYDSEP-VPASLCPQP--APSSRQACNSQSCPPAWSAGPWAECSH 1000
GG Q C +H ++ V SLC P+ QACN++ CPP W G W CS
Sbjct: 661 VGGHQEAIAVC---LHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
Query: 1001 TCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAW 1060
TCG G + R V C + P C E KP +AC C W + W
Sbjct: 718 TCGVGIQTRDVYCLHPGETPA----PPEECRDE-KPHALQACNQFDCPPG----WHIEEW 768
Query: 1061 SQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPF 1120
QCS TC GTQ R + C + G + L+ + C P ++CA CP H
Sbjct: 769 QQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG---PKASSHKSCARTDCPPH--- 822
Query: 1121 AAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
A G WS+C+ SCG G+Q R C
Sbjct: 823 LAVGD---------WSKCSVSCGVGIQRRKQVC 846
Score = 109 bits (272), Expect = 2e-23
Identities = 95/352 (26%), Positives = 134/352 (38%), Gaps = 72/352 (20%)
Query: 881 CSVSCGGGQ-----MTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGN 935
CSVSCGGG + V E + ++ QV C +P + C + CP W
Sbjct: 430 CSVSCGGGIQRRSFVCVEESMHGEI-LQVEEWKCMYAPKPKV-MQTCNLFDCP-KWIAME 486
Query: 936 WSACSRTCGGGAQSRPVQCTR-------------RVHYDSEPVPASLCPQPAPSS----- 977
WS C+ TCG G + R V C ++H E V C +P S
Sbjct: 487 WSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAK 546
Query: 978 ----RQACNSQSC-----PPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL-LPD 1027
+QA + P + PW+ CS TCG G + R V C+ + + LP+
Sbjct: 547 LPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE 606
Query: 1028 AVCTSEPKPRMHEACLLQRCHKPKKLQ---------------WLVSAWSQCSVTCERGTQ 1072
C PK CLL+ C + + W + ++ C+ TC G Q
Sbjct: 607 EECEG-PKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQ 665
Query: 1073 KRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA 1132
+ C + + C + +P + +AC PCP W
Sbjct: 666 EAIAVCLHIQTQ---QTVNDSLCDMVHRPPA-MSQACNTEPCPPR------------WHV 709
Query: 1133 SPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
W C+A+CG G+QTR V CL G P C +KP A ACN CP
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCP 760
Score = 102 bits (253), Expect = 3e-21
Identities = 74/250 (29%), Positives = 104/250 (41%), Gaps = 17/250 (6%)
Query: 812 SGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR---NPGVAWEYSMP-----RLGTE 863
S TT+D+ + P G E + V L Q + N + P TE
Sbjct: 642 SETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTE 701
Query: 864 KQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCK 923
PP +W CS +CG G T C + C + +P L C
Sbjct: 702 PCPPRWHVGSWG----PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KP-HALQACN 755
Query: 924 VSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPAS--LCPQPAPSSRQAC 981
CPP W + W CSRTCGGG Q+R V C R++ D + S LC P SS ++C
Sbjct: 756 QFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC-RQLLTDGSFLNLSDELCQGPKASSHKSC 814
Query: 982 NSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
CPP + G W++CS +CG G ++R C+ R L + +C P + +
Sbjct: 815 ARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRS 874
Query: 1042 CLLQRCHKPK 1051
C + C K K
Sbjct: 875 CQMPECSKIK 884
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/249 (27%), Positives = 98/249 (39%), Gaps = 31/249 (12%)
Query: 862 TEKQPPAQPSY---TWAIVRSECSVSCGG-GQMTVREGCYRDLKFQVNMSFCNPKTRPVT 917
T + PP +P + W S CS +CG G R C +V+ + C+ +P+
Sbjct: 1418 TGEPPPQEPFWEPGNW----SHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLA 1473
Query: 918 GLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPV--PASLCPQPAP 975
G PC + CP W WS CS +CG G SR V C R + V P + P+ P
Sbjct: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRP 1533
Query: 976 SSRQACNSQSCPPAWSAGPWAECSHTC-GKGWR--KRAVACKSTNPSARAQLLPDAVCTS 1032
R+ C C W P C C G+ R +R AC+ + D+ C
Sbjct: 1534 LGRKPCFGHPC-VQWE--PGNRCPGRCMGRAVRMQQRHTACQHNS--------SDSNCDD 1582
Query: 1033 EPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELAS 1092
+P + C C + W W C+ C RG Q R + C + + +A
Sbjct: 1583 RKRPTLRRNCTSGAC----DVCWHTGPWKPCTAACGRGFQSRKVDCIH---TRSCKPVAK 1635
Query: 1093 KKCSHLPKP 1101
+ C KP
Sbjct: 1636 RHCVQKKKP 1644
Score = 86.7 bits (213), Expect = 1e-16
Identities = 76/325 (23%), Positives = 116/325 (35%), Gaps = 76/325 (23%)
Query: 879 SECSVSCGGGQ-----MTVRE------GCYRDLKFQVNMSFCNP-------KTRPVTGLV 920
S+C+V+CG G + + GC LK + P + PV +
Sbjct: 488 SQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL 547
Query: 921 P----------CKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEP--VPAS 968
P +++ P++ WSACS TCG G Q R V+C + + +P
Sbjct: 548 PWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEE 607
Query: 969 LCPQPAPSSRQACNSQSCPPA-------------------WSAGPWAECSHTCGKGWRKR 1009
C P + + C ++C + W + C+ TC G ++
Sbjct: 608 ECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEA 667
Query: 1010 AVACKSTNPSARAQLLPDAVCTSEPKP-RMHEACLLQRCHKPKKLQWLVSAWSQCSVTCE 1068
C Q + D++C +P M +AC + C +W V +W CS TC
Sbjct: 668 IAVCLHIQTQ---QTVNDSLCDMVHRPPAMSQACNTEPCPP----RWHVGSWGPCSATCG 720
Query: 1069 RGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRG 1128
G Q R + C + E + H + AC CP
Sbjct: 721 VGIQTRDVYCLHPGETPAPPEECRDEKPHALQ-------ACNQFDCPP------------ 761
Query: 1129 SWFASPWSQCTASCGGGVQTRSVQC 1153
W W QC+ +CGGG Q R V C
Sbjct: 762 GWHIEEWQQCSRTCGGGTQNRRVTC 786
Score = 38.9 bits (89), Expect = 0.030
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 594 SWSPCSRTCGGGVSHRSRLCTNP--KPSHGGKFCEGSTRTLKLCNSQKCP 641
SW PCS TCG G+ R C +P P+ + + L+ CN CP
Sbjct: 711 SWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
Score = 36.2 bits (82), Expect = 0.20
Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 5/68 (7%)
Query: 1119 PFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQC-LAGGRPASGCLLH--QKPSASL- 1173
P P W WS C+A+CG G + + QC +A G+ S L QKP A
Sbjct: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFE 1476
Query: 1174 ACNTHFCP 1181
CN CP
Sbjct: 1477 PCNIRDCP 1484
Score = 31.6 bits (70), Expect = 4.8
Identities = 11/19 (57%), Positives = 12/19 (63%)
Query: 595 WSPCSRTCGGGVSHRSRLC 613
W CSRTCGGG +R C
Sbjct: 768 WQQCSRTCGGGTQNRRVTC 786
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 279 bits (714), Expect = 1e-74
Identities = 207/666 (31%), Positives = 289/666 (43%), Gaps = 103/666 (15%)
Query: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
G W W WS CSRTCGGG S+ R C + K CEG + C++ CP ++ D
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
Query: 647 FRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSE 706
FRA QC+ HN + G+ Y+W P + D C L C A+G L+ KV DGT C
Sbjct: 88 FRAQQCSAHNDVKHHGQFYEWLPVSNDPDNP-CSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 707 DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY-TKHHHTNQYYHMV 765
+S ++CI G+C+ VGCD+ LGS ED CGVCNG+ S C + RG Y ++ T +V
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 766 TIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEP 825
IP G+R IR+ Y+ + G ++ G + ++ D+++ + +
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTL---QGTKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
Query: 826 ENLIATGPTNETLIVELLFQG-RNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVS 884
E L GP IV++ G + V + + P + ++ P CS +
Sbjct: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFP----------CSAT 312
Query: 885 CGGGQMTVREGCYRDLKFQ--VNMSFCN---PKTRPVTGLVPCKVSACP----------- 928
CGGG CY DL+ V +C+ +P L C + CP
Sbjct: 313 CGGGYQLTSAECY-DLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPY 371
Query: 929 ------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEPVPASLCP-QPAPSSRQA 980
P W W+ACS +CGGG QSR V C + V C P Q
Sbjct: 372 DLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQP 431
Query: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
CN C P W A W+ C+ TCG+G R R V C + C+ + KP + E
Sbjct: 432 CNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG------MHTGGCSPKTKPHIKE 484
Query: 1041 ACLLQR-CHKPK-------KLQW-------------------LVSAWSQCSVTCERGTQK 1073
C++ C+KPK KL W + AWS C+VTC GTQ
Sbjct: 485 ECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQV 544
Query: 1074 RFLKCAEKY-VSGKYRELASKKCSHLPKPSLELERACAPLPC----PRHPPFAAAGPSRG 1128
R ++C S +L +C PKP+ +RAC PC P P G G
Sbjct: 545 RIVRCQVLLSFSQSVADLPIDECEG-PKPA--SQRACYAGPCSGEIPEFNPDETDGLFGG 601
Query: 1129 --------SWFASPWSQCTASCGGGVQTRSVQCL--AGGRPASG--CLLHQKPSASL-AC 1175
W +++C+ SCGGGVQ V CL PA C+ ++P L +C
Sbjct: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
Query: 1176 NTHFCP 1181
N CP
Sbjct: 662 NLDPCP 667
Score = 157 bits (398), Expect = 4e-38
Identities = 90/254 (35%), Positives = 118/254 (46%), Gaps = 14/254 (5%)
Query: 879 SECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWS 937
++CS SCGGG C + + + C RP L C + CP W +G WS
Sbjct: 617 TKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWS 676
Query: 938 ACSRTCGGGAQSRPVQCTR---RVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGP 994
CS TCG G Q+R V C+ R ++ + LC QP PS+ QACN +CPPAW
Sbjct: 677 PCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQ 736
Query: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQ 1054
W CS TCG G +KR V CK LP+ C S KP +AC C +
Sbjct: 737 WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPACQQACKKDDCPS----E 791
Query: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP-----KPSLELERAC 1109
WL+S W++CS +C GTQ R C + +G + S C LP +P + A
Sbjct: 792 WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR 851
Query: 1110 APLPCPRHPPFAAA 1123
P +H P AA
Sbjct: 852 PGRPSTKHSPHIAA 865
Score = 129 bits (324), Expect = 2e-29
Identities = 75/227 (33%), Positives = 101/227 (44%), Gaps = 26/227 (11%)
Query: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC--PQPAPSSRQACNSQSCPP 988
W ++ CS +CGGG Q V C + EP +LC + P ++CN CP
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNK--QTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Query: 989 AWSAGPWAECSHTCGKGWRKRAVACKS--TNPSARAQLLPDAVCTSEPKPRMHEACLLQR 1046
W G W+ CS TCG G + R V C + +L D +C +PKP +AC
Sbjct: 669 RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFN 727
Query: 1047 CHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELE 1106
C W + W CS TC G QKR + C ++ G + EL CS KP+ +
Sbjct: 728 CPPA----WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQ-- 780
Query: 1107 RACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
+AC CP W S W++C+ SCG G QTRS C
Sbjct: 781 QACKKDDCP------------SEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 118 bits (296), Expect = 3e-26
Identities = 77/240 (32%), Positives = 113/240 (47%), Gaps = 22/240 (9%)
Query: 872 YTWAIVR-SECSVSCGG-GQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPP 929
Y W++ R + CS SCG G R C + +VN + C K RP + C CP
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLN-STEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Query: 930 SWSVGNWSACSRTCGGGAQSRPVQCTR-RVHYDSEPVPASLCPQPA--PSSRQACNSQSC 986
W V +WSAC+R+CGGG Q+R V C + + S PV +C Q A P QACN Q C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 987 PPAWSAGPWAECSHTC---GKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACL 1043
W+ W +C+ C + R V C++ + LP C++ P+P + C
Sbjct: 1608 -VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD----GITLPSEQCSALPRPVSTQNCW 1662
Query: 1044 LQRCHKPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
+ C + W VS W+ C+ TC G Q R ++C + + + CS P+P+
Sbjct: 1663 SEAC----SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN---KAVPEHLCSWGPRPA 1715
Score = 117 bits (293), Expect = 7e-26
Identities = 87/303 (28%), Positives = 129/303 (42%), Gaps = 42/303 (13%)
Query: 931 WSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQ-ACNSQSCPP 988
WSV + CS +CG G Q ++C +E PA + P+ + ACN + CP
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLN---STEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Query: 989 AWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPK-PRMHEACLLQRC 1047
W W+ C+ +CG G + R V C+ S + + + +CT K P +AC Q C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 1048 HKPKKLQWLVSAWSQCSVTC---ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
++W S+W QC+ C Q R + C + L S++CS LP+P
Sbjct: 1608 -----VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR----DGITLPSEQCSALPRPVST 1658
Query: 1105 LERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGG-GVQTRSVQCLAGGR----P 1159
+ C C H W S W+ CTA+CG G Q+R V+C+ P
Sbjct: 1659 --QNCWSEACSVH------------WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVP 1704
Query: 1160 ASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTC 1219
C +P+ CN C E C+D +C V Q +C + +CC TC
Sbjct: 1705 EHLCSWGPRPANWQRCNITPCENME-----CRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
Query: 1220 SKS 1222
K+
Sbjct: 1760 GKA 1762
Score = 110 bits (276), Expect = 6e-24
Identities = 84/290 (28%), Positives = 120/290 (41%), Gaps = 61/290 (21%)
Query: 929 PSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSE--PVPASLCPQPAPSSRQACNSQSC 986
PS+ WSAC+ TCG G Q R V+C + + +P C P P+S++AC + C
Sbjct: 524 PSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPC 583
Query: 987 PPA------------------------WSAGPWAECSHTCGKGWRKRAVACKSTNPSARA 1022
W + +CS +CG G ++ V+C N R
Sbjct: 584 SGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC--LNKQTRE 641
Query: 1023 QLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKY 1082
+ TS P++ ++C L C +W + WS CS+TC G Q R + C+
Sbjct: 642 PAEENLCVTSRRPPQLLKSCNLDPC----PARWEIGKWSPCSLTCGVGLQTRDVFCSH-L 696
Query: 1083 VSGKYRE---LASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCT 1139
+S + E LA + C PKPS +AC CP +W+ + W C+
Sbjct: 697 LSREMNETVILADELCRQ-PKPSTV--QACNRFNCPP------------AWYPAQWQPCS 741
Query: 1140 ASCGGGVQTRSVQCLAGGRPASGCLLH--------QKPSASLACNTHFCP 1181
+CGGGVQ R V C R A G L KP+ AC CP
Sbjct: 742 RTCGGGVQKREVLCKQ--RMADGSFLELPETFCSASKPACQQACKKDDCP 789
Score = 90.9 bits (224), Expect = 7e-18
Identities = 94/365 (25%), Positives = 132/365 (36%), Gaps = 83/365 (22%)
Query: 881 CSVSCGGGQMTVREGCYR-DLKFQVNM-----SFCNPKTRPVTGLVPCKVSACPPSWSVG 934
CS SCGGG + C D++ V PK P+ PC + CP W
Sbjct: 388 CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM-PIAQ--PCNIFDCP-KWLAQ 443
Query: 935 NWSACSRTCGGGAQSRPVQCT-------------RRVHYDSEPVPASLCPQPA------- 974
WS C+ TCG G + R V C + H E + + C +P
Sbjct: 444 EWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEA 503
Query: 975 --PSSRQACNSQ-----SCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQL-LP 1026
P +QA + S P++ W+ C+ TCG G + R V C+ +++ LP
Sbjct: 504 KLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLP 563
Query: 1027 DAVCTSEPKPRMHEACLLQRCHKP--------------------KKLQWLVSAWSQCSVT 1066
C PKP AC C + W +++CS +
Sbjct: 564 IDECEG-PKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSES 622
Query: 1067 CERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPS 1126
C G Q+ + C K RE A + + +L ++C PCP
Sbjct: 623 CGGGVQEAVVSCLNKQT----REPAEENLCVTSRRPPQLLKSCNLDPCPAR--------- 669
Query: 1127 RGSWFASPWSQCTASCGGGVQTRSVQC--LAGGRPASGCLL------HQKPSASLACNTH 1178
W WS C+ +CG G+QTR V C L +L KPS ACN
Sbjct: 670 ---WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRF 726
Query: 1179 FCPIA 1183
CP A
Sbjct: 727 NCPPA 731
Score = 39.3 bits (90), Expect = 0.023
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 8/58 (13%)
Query: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSHGG------KFCEGSTRTL-KLCNSQKCPRD 643
+ W PCSRTCGGGV R LC + + G FC S + C CP +
Sbjct: 735 AQWQPCSRTCGGGVQKREVLC-KQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791
Score = 34.7 bits (78), Expect = 0.57
Identities = 23/77 (29%), Positives = 27/77 (35%), Gaps = 31/77 (40%)
Query: 584 PTHGHWSDWSSWSPCSRTCGGGVSHR-------------------SRLCTNPKPSHGGKF 624
P W + WSPCS TCG G+ R LC PKPS
Sbjct: 665 PCPARW-EIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPS----- 718
Query: 625 CEGSTRTLKLCNSQKCP 641
T++ CN CP
Sbjct: 719 ------TVQACNRFNCP 729
Score = 34.3 bits (77), Expect = 0.75
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPS 619
+SWS C+R+CGGGV R C K S
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKAS 1578
Score = 30.8 bits (68), Expect = 8.3
Identities = 12/26 (46%), Positives = 16/26 (61%), Gaps = 2/26 (7%)
Query: 590 SDW--SSWSPCSRTCGGGVSHRSRLC 613
S+W S W+ CS +CG G RS +C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAIC 815
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 272 bits (696), Expect = 1e-72
Identities = 176/559 (31%), Positives = 249/559 (44%), Gaps = 81/559 (14%)
Query: 564 GHDMWCRGGQCVKYGDE-GPKPTH-GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHG 621
G W GG +G P P H G W S P H S L + PS
Sbjct: 313 GQGPWGTGG--TPHGPRLEPDPQHPGAWLPLLSNGP----------HASSLWSLFAPSSP 360
Query: 622 GKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKL 681
C G + L+ C+ CP + D RA QCA NS+ F G+ Y+W+P+T+V+ C+L
Sbjct: 361 IPRCSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCEL 420
Query: 682 YCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGN 741
C GF F+ + KV+DGT C + ++C+ G C GCD +LGS D CGVC G+
Sbjct: 421 NCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGD 480
Query: 742 NSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHW 801
+S C + G T Y ++ IP+GA ++I ++ S++Y+++R R +NG+W
Sbjct: 481 DSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNW 540
Query: 802 TVDWPGRYKFSGTTFDYRRSYNEP---ENLIATGPTNETLIVELLFQGRNPGVAWEY--- 855
VD PG Y+ GT F Y R E E+L A GPT + + V ++FQ NPGV ++Y
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVIS 600
Query: 856 -------------SMPRLGTE---KQPPAQP----------------------------- 870
+P+L E +PP P
Sbjct: 601 SPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTP 660
Query: 871 -----SYTWAIVRSECSVSCGGGQMTVREGCY-RDLKFQVNMSFCNPKTRPVTGLVPCKV 924
+Y + S CS SCG G C R+ +++ C RP PC
Sbjct: 661 LGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Query: 925 SACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ-PAPSSRQACNS 983
+ CPP W G W++CSR+CG G Q R +QC + VP C P P+ Q+C
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQL 780
Query: 984 QSCPPAWSAG-PWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
+ C W G PW++CS CG+G R R V C N ++ + P+P EAC
Sbjct: 781 RLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGD---EVSEQECASGPPQPPSREAC 836
Query: 1043 LLQRCHKPKKLQWLVSAWS 1061
+ C W S WS
Sbjct: 837 DMGPC----TTAWFHSDWS 851
Score = 74.7 bits (182), Expect = 5e-13
Identities = 48/167 (28%), Positives = 74/167 (44%), Gaps = 25/167 (14%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCH- 1048
W + CS +CGKG + C S L + C + +P + CH
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEE---LDERSCAAGARPPASP----EPCHG 720
Query: 1049 KPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERA 1108
P W W+ CS +C GTQ R L+C +++ G + ++C HLP+P++ ++
Sbjct: 721 TPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGG-SSVPPERCGHLPRPNIT--QS 777
Query: 1109 CAPLPCPRHPPFAAAGPSRGSW-FASPWSQCTASCGGGVQTRSVQCL 1154
C C G W SPWSQC+ CG G ++R V+C+
Sbjct: 778 CQLRLC-------------GHWEVGSPWSQCSVRCGRGQRSRQVRCV 811
Score = 52.4 bits (124), Expect = 3e-06
Identities = 37/132 (28%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
W S CS +C +G + C + SG+ EL + C+ +P E C PC
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRE-SGE--ELDERSCAAGARPPASPE-PCHGTPC 723
Query: 1115 PRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC---LAGGR---PASGCLLHQK 1168
P + W A W+ C+ SCG G Q R +QC GG P C +
Sbjct: 724 PPY------------WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
Query: 1169 PSASLACNTHFC 1180
P+ + +C C
Sbjct: 772 PNITQSCQLRLC 783
Score = 42.4 bits (98), Expect = 0.003
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
+EG P G W W W+ CS+ CG GV RSR C P
Sbjct: 38 EEGQGP-EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 32.3 bits (72), Expect = 2.8
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQL-LPDAVCTSEPKPRMHEACLLQRCHKPK 1051
WA CS CG G ++R+ C+ L LP P+P H LL R P+
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLP-------PRPPRHPEALLPRGQGPR 103
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 238 bits (607), Expect = 3e-62
Identities = 183/560 (32%), Positives = 264/560 (47%), Gaps = 82/560 (14%)
Query: 40 PSVPRPPPPA--------ERPGWM--EKGEYDLVSAYEVDHRGDYVSHEIMHHQRR---- 85
P +P PPPPA + PG E L D +G VSH + R
Sbjct: 26 PLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR 85
Query: 86 -RRAVPV---------SEVESLHL--RLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGT 133
RRA PV E HL + D H+ LR ++ LVAPG ++ G+ GT
Sbjct: 86 ARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGT 145
Query: 134 KSVQTLPPEDFCFYQGSLRSHRN-SSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLG 192
V+ L C Y G + SSVALS C GL+G+IR EE ++F+ PL L+ +
Sbjct: 146 TRVEPLLGS--CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQ-- 201
Query: 193 RAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRR 252
A QG HV+Y+R G + L T + + L S LG
Sbjct: 202 EAEQGRV--HVVYRRPPTSPPLGGPQALDTGASLD----SLDSLSRALG----------- 244
Query: 253 KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENIT 312
+L + S R R R +++ N+E L+ VD ++Q HG E++
Sbjct: 245 -------------VLEEHANSSRRRAR---RHAADDDYNIEVLLGVDDSVVQFHGKEHVQ 288
Query: 313 TYVLTILNMVSALFKDGTIGGNINIAIVGLILLE-DEQPGLVISHHADHTLSSFCQWQSG 371
Y+LT++N+V+ ++ D ++G +IN+ +V +ILL + L+ + +L + C+W +
Sbjct: 289 KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRW-AY 347
Query: 372 LMGKDGTRHD----HAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427
L K T HD HAI LT D P G+AP++GMC RSCT+N + G
Sbjct: 348 LQQKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSS 402
Query: 428 AFTIAHESGHNFGMIHDGEGNMC--KKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLST 485
AF +AHE+GH GM HDG+GN C + G+IM+P + F WS CS+Q L ++L +
Sbjct: 403 AFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS 462
Query: 486 AQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545
CL D P ++ +LPG Y N QC++ FG +C D CK LWC
Sbjct: 463 YD--CLLDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSH 519
Query: 546 IGRK--CETKFMPAAEGTIC 563
C+TK P +GT+C
Sbjct: 520 PDNPYFCKTKKGPPLDGTMC 539
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 238 bits (606), Expect = 3e-62
Identities = 160/507 (31%), Positives = 226/507 (44%), Gaps = 63/507 (12%)
Query: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVD 646
G W W WS CSRTCGGG S+ R C + K CEG + C++ CP ++ D
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
Query: 647 FRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSE 706
FRA QC+ HN + G+ Y+W P + D C L C A+G L+ KV DGT C
Sbjct: 88 FRAQQCSAHNDVKHHGQFYEWLPVSNDPDNP-CSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 707 DSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY-TKHHHTNQYYHMV 765
+S ++CI G+C+ VGCD+ LGS ED CGVCNG+ S C + RG Y ++ T +V
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 766 TIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEP 825
IP G+R IR+ Y+ + G ++ G + ++ D+++ + +
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTL---QGTKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
Query: 826 ENLIATGPTNETLIVELLFQG-RNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVS 884
E L GP IV++ G + V + + P + ++ P CS +
Sbjct: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFP----------CSAT 312
Query: 885 CGGGQMTVREGCYRDLKFQ--VNMSFCN---PKTRPVTGLVPCKVSACP----------- 928
CGGG CY DL+ V +C+ +P L C + CP
Sbjct: 313 CGGGYQLTSAECY-DLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPY 371
Query: 929 ------PSWSVGNWSACSRTCGGGAQSRPVQCTRR-VHYDSEPVPASLCP-QPAPSSRQA 980
P W W+ACS +CGGG QSR V C + V C P Q
Sbjct: 372 DLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQP 431
Query: 981 CNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
CN C P W A W+ C+ TCG+G R R V C + C+ + KP + E
Sbjct: 432 CNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG------MHTGGCSPKTKPHIKE 484
Query: 1041 ACLLQR-CHKPK-------KLQWLVSA 1059
C++ C+KPK KL W A
Sbjct: 485 ECIVPTPCYKPKEKLPVEAKLPWFKQA 511
Score = 80.9 bits (198), Expect = 7e-15
Identities = 55/205 (26%), Positives = 83/205 (40%), Gaps = 38/205 (18%)
Query: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVC-----TSEPKPRMHEACLL 1044
W + CS TCG G++ + C + +++ D C +PKP++ E C L
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSN---RVVADQYCHYYPENIKPKPKLQE-CNL 356
Query: 1045 QRCHK--------PKKL-----QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELA 1091
C P L +W + W+ CS +C G Q R + C E+ + G +
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 1092 SKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSV 1151
KC + PK + + + C CP+ W A WS CT +CG G++ R V
Sbjct: 417 EWKCMYTPK--MPIAQPCNIFDCPK-------------WLAQEWSPCTVTCGQGLRYRVV 461
Query: 1152 QCL-AGGRPASGCLLHQKPSASLAC 1175
C+ G GC KP C
Sbjct: 462 LCIDHRGMHTGGCSPKTKPHIKEEC 486
Score = 62.8 bits (151), Expect = 2e-09
Identities = 46/149 (30%), Positives = 67/149 (44%), Gaps = 19/149 (12%)
Query: 1048 HKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP---KPSLE 1104
++P +W + + CS TC G Q L AE Y R +A + C + P KP +
Sbjct: 294 YQPIIHRWRETDFFPCSATCGGGYQ---LTSAECYDLRSNRVVADQYCHYYPENIKPKPK 350
Query: 1105 LERACAPLPCPRHPPFAAAGP-----SRGSWFASPWSQCTASCGGGVQTRSVQCL---AG 1156
L+ C PCP + P W A+PW+ C++SCGGG+Q+R+V C+
Sbjct: 351 LQE-CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQ 409
Query: 1157 GRPAS----GCLLHQKPSASLACNTHFCP 1181
G S C+ K + CN CP
Sbjct: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 32.3 bits (72), Expect = 2.8
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLA 1155
G W A PWS+C+ +CGGG +CL+
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS 62
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,086,668
Number of Sequences: 37866
Number of extensions: 3218531
Number of successful extensions: 16710
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 14193
Number of HSP's gapped (non-prelim): 1137
length of query: 1224
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1110
effective length of database: 13,930,794
effective search space: 15463181340
effective search space used: 15463181340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.