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Search of human proteins with 167466233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
(388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 783 0.0
gi|146219832 myosin light chain kinase 3 [Homo sapiens] 442 e-124
gi|14993776 skeletal myosin light chain kinase [Homo sapiens] 376 e-104
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 297 1e-80
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 297 1e-80
gi|14670383 death-associated kinase 2 [Homo sapiens] 249 4e-66
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 244 7e-65
gi|4557511 death-associated protein kinase 3 [Homo sapiens] 240 2e-63
gi|110349719 titin isoform N2-A [Homo sapiens] 229 4e-60
gi|110349717 titin isoform novex-2 [Homo sapiens] 229 4e-60
gi|110349713 titin isoform novex-1 [Homo sapiens] 229 4e-60
gi|110349715 titin isoform N2-B [Homo sapiens] 229 4e-60
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 221 1e-57
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 221 1e-57
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 209 3e-54
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 202 3e-52
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 202 3e-52
gi|4758194 serine/threonine kinase 17B [Homo sapiens] 200 2e-51
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 194 1e-49
gi|27901803 protein serine kinase H1 [Homo sapiens] 182 3e-46
gi|157785645 SPEG complex locus [Homo sapiens] 179 3e-45
gi|14916455 protein serine kinase H2 [Homo sapiens] 179 4e-45
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 176 3e-44
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 176 3e-44
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 174 2e-43
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 172 5e-43
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 172 5e-43
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 172 5e-43
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 172 5e-43
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 172 5e-43
>gi|167466233 myosin light chain kinase family, member 4 [Homo
sapiens]
Length = 388
Score = 783 bits (2021), Expect = 0.0
Identities = 388/388 (100%), Positives = 388/388 (100%)
Query: 1 MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN 60
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN
Sbjct: 1 MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN 60
Query: 61 ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV 120
ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV
Sbjct: 61 ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV 120
Query: 121 HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM 180
HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM
Sbjct: 121 HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM 180
Query: 181 EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA 240
EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA
Sbjct: 181 EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA 240
Query: 241 KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL 300
KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL
Sbjct: 241 KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL 300
Query: 301 SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW 360
SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW
Sbjct: 301 SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW 360
Query: 361 LSDHKLHSRLNAQKKKNRGSDAQDFVTK 388
LSDHKLHSRLNAQKKKNRGSDAQDFVTK
Sbjct: 361 LSDHKLHSRLNAQKKKNRGSDAQDFVTK 388
>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
Length = 819
Score = 442 bits (1138), Expect = e-124
Identities = 208/303 (68%), Positives = 254/303 (83%)
Query: 61 ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV 120
A+ RMP ++ S + D PAPPAPF+HR+V+ K+ ++++ Y V + E+LGGGRFGQV
Sbjct: 470 AEAVRRMPPGAEAGSVVLDDSPAPPAPFEHRVVSVKETSISAGYEVCQHEVLGGGRFGQV 529
Query: 121 HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM 180
H+C E +TGL LAAKIIK + KD+E+VKNEI++MNQL H NLIQLYDAFESK+ LVM
Sbjct: 530 HRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVM 589
Query: 181 EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA 240
EYVDGGELFDRI DE Y+LTELD +LF +QICEG+ ++HQ YILHLDLKPENILCVN+
Sbjct: 590 EYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTG 649
Query: 241 KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL 300
QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNY+FVSFPTDMWSVGVI YMLLSGL
Sbjct: 650 HQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGL 709
Query: 301 SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW 360
SPFLG+ DAET+N I+ C WD + + F+ +SEEAK+F+S+LL+KEKS R+SA++ LKH W
Sbjct: 710 SPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEW 769
Query: 361 LSD 363
L++
Sbjct: 770 LNN 772
>gi|14993776 skeletal myosin light chain kinase [Homo sapiens]
Length = 596
Score = 376 bits (966), Expect = e-104
Identities = 178/284 (62%), Positives = 229/284 (80%)
Query: 80 DIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKT 139
D P PPAPF HR+V + G V+S ++++ E LGGG+FG V C E ATGLKLAAK+IK
Sbjct: 259 DCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKK 318
Query: 140 RGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL 199
+ KDKE V EI VMNQL+H NLIQLY A E+ ++IVL MEY++GGELF+RI+DE Y+L
Sbjct: 319 QTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHL 378
Query: 200 TELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREK 259
TE+DT++F++QIC+GI MH+M +LHLDLKPENILCVN +KIIDFGLARRY P EK
Sbjct: 379 TEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEK 438
Query: 260 LKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR 319
LKVNFGTPEFL+PEVVNYD +S TDMWS+GVI YMLLSGLSPFLGD+D ETLNN+L+
Sbjct: 439 LKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGN 498
Query: 320 WDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 363
W ++E F+ +S+EAK+F+S L++K++ R++A++ L HPWL++
Sbjct: 499 WYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNN 542
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 297 bits (760), Expect = 1e-80
Identities = 145/274 (52%), Positives = 195/274 (71%), Gaps = 3/274 (1%)
Query: 89 DHRIVTAK-QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE 147
D+R VT + V+ FY + E LG G+FGQV + E T A K K K+KE
Sbjct: 1448 DYRTVTINTEQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN 1505
Query: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207
++ EIS+MN L H L+Q DAFE K +IV+V+E V GGELF+RIIDE + LTE + I +
Sbjct: 1506 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1565
Query: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
M+QI EG+ ++H+ I+HLDLKPENI+CVN+ +IK+IDFGLARR + LKV FGTP
Sbjct: 1566 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTP 1625
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APEV+NY+ + + TDMWS+GVI Y+L+SGLSPF+GDND ETL N+ + WD +DE F
Sbjct: 1626 EFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAF 1685
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361
+IS++AK+FIS LL K+ R+ ++ L+HPWL
Sbjct: 1686 DEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL 1719
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 297 bits (760), Expect = 1e-80
Identities = 145/274 (52%), Positives = 195/274 (71%), Gaps = 3/274 (1%)
Query: 89 DHRIVTAK-QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE 147
D+R VT + V+ FY + E LG G+FGQV + E T A K K K+KE
Sbjct: 1379 DYRTVTINTEQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN 1436
Query: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207
++ EIS+MN L H L+Q DAFE K +IV+V+E V GGELF+RIIDE + LTE + I +
Sbjct: 1437 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1496
Query: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
M+QI EG+ ++H+ I+HLDLKPENI+CVN+ +IK+IDFGLARR + LKV FGTP
Sbjct: 1497 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTP 1556
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APEV+NY+ + + TDMWS+GVI Y+L+SGLSPF+GDND ETL N+ + WD +DE F
Sbjct: 1557 EFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAF 1616
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361
+IS++AK+FIS LL K+ R+ ++ L+HPWL
Sbjct: 1617 DEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL 1650
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 249 bits (635), Expect = 4e-66
Identities = 128/275 (46%), Positives = 182/275 (66%), Gaps = 11/275 (4%)
Query: 96 KQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMK------DKEEVK 149
KQ V FY + E LG G+F V KC E +TGL+ AAK IK R + +EE++
Sbjct: 15 KQQKVEDFYDIG--EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIE 72
Query: 150 NEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMK 209
E+S++ Q+ H N+I L+D +E++ D+VL++E V GGELFD + + +L+E + F+K
Sbjct: 73 REVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFD-FLAQKESLSEEEATSFIK 131
Query: 210 QICEGIRHMHQMYILHLDLKPENILCVNRDAK--QIKIIDFGLARRYKPREKLKVNFGTP 267
QI +G+ ++H I H DLKPENI+ ++++ IK+IDFGLA + + K FGTP
Sbjct: 132 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 191
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APE+VNY+ + DMWS+GVI Y+LLSG SPFLGD ETL NI A +D ++E F
Sbjct: 192 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFF 251
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWLS 362
SE AK+FI KLL+KE R++ EAL+HPW++
Sbjct: 252 SQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 286
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 244 bits (624), Expect = 7e-65
Identities = 123/274 (44%), Positives = 182/274 (66%), Gaps = 11/274 (4%)
Query: 96 KQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD------KEEVK 149
+Q V+ +Y E LG G+F V KC E +TGL+ AAK IK R K +E+++
Sbjct: 5 RQENVDDYYDTG--EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIE 62
Query: 150 NEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMK 209
E+S++ ++ H N+I L++ +E+K D++L++E V GGELFD + E +LTE + F+K
Sbjct: 63 REVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFD-FLAEKESLTEEEATEFLK 121
Query: 210 QICEGIRHMHQMYILHLDLKPENILCVNRDAKQ--IKIIDFGLARRYKPREKLKVNFGTP 267
QI G+ ++H + I H DLKPENI+ ++R+ + IKIIDFGLA + + K FGTP
Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APE+VNY+ + DMWS+GVI Y+LLSG SPFLGD ETL N+ A ++ EDE F
Sbjct: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361
+ S AK+FI +LL+K+ R++ ++L+HPW+
Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI 275
>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
Length = 454
Score = 240 bits (612), Expect = 2e-63
Identities = 120/276 (43%), Positives = 182/276 (65%), Gaps = 11/276 (3%)
Query: 94 TAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD------KEE 147
T +Q V Y + E LG G+F V KC + TG + AAK IK R + +EE
Sbjct: 3 TFRQEDVEDHYEMG--EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60
Query: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207
++ E++++ ++ H N+I L+D FE+K D+VL++E V GGELFD + E +LTE + F
Sbjct: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFD-FLAEKESLTEDEATQF 119
Query: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAK--QIKIIDFGLARRYKPREKLKVNFG 265
+KQI +G+ ++H I H DLKPENI+ ++++ +IK+IDFG+A + + + K FG
Sbjct: 120 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 179
Query: 266 TPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDE 325
TPEF+APE+VNY+ + DMWS+GVI Y+LLSG SPFLG+ ETL NI A +D ++E
Sbjct: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE 239
Query: 326 EFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361
F + SE AK+FI +LL+K+ R++ +++L+H W+
Sbjct: 240 YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 229 bits (583), Expect = 4e-60
Identities = 105/252 (41%), Positives = 171/252 (67%), Gaps = 1/252 (0%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 169
E LG G FG VH+C ET++ AK +K +G D+ VK EIS++N H N++ L+++
Sbjct: 31255 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 31313
Query: 170 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK 229
FES ++V++ E++ G ++F+RI ++ L E + + ++ Q+CE ++ +H I H D++
Sbjct: 31314 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 31373
Query: 230 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSV 289
PENI+ R + IKII+FG AR+ KP + ++ F PE+ APEV +D VS TDMWS+
Sbjct: 31374 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 31433
Query: 290 GVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWR 349
G + Y+LLSG++PFL + + + + NI+ + ++E F++IS EA +F+ +LL+KE+ R
Sbjct: 31434 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 31493
Query: 350 ISASEALKHPWL 361
++ASEAL+HPWL
Sbjct: 31494 MTASEALQHPWL 31505
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 229 bits (583), Expect = 4e-60
Identities = 105/252 (41%), Positives = 171/252 (67%), Gaps = 1/252 (0%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 169
E LG G FG VH+C ET++ AK +K +G D+ VK EIS++N H N++ L+++
Sbjct: 24950 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 25008
Query: 170 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK 229
FES ++V++ E++ G ++F+RI ++ L E + + ++ Q+CE ++ +H I H D++
Sbjct: 25009 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 25068
Query: 230 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSV 289
PENI+ R + IKII+FG AR+ KP + ++ F PE+ APEV +D VS TDMWS+
Sbjct: 25069 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 25128
Query: 290 GVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWR 349
G + Y+LLSG++PFL + + + + NI+ + ++E F++IS EA +F+ +LL+KE+ R
Sbjct: 25129 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 25188
Query: 350 ISASEALKHPWL 361
++ASEAL+HPWL
Sbjct: 25189 MTASEALQHPWL 25200
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 229 bits (583), Expect = 4e-60
Identities = 105/252 (41%), Positives = 171/252 (67%), Gaps = 1/252 (0%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 169
E LG G FG VH+C ET++ AK +K +G D+ VK EIS++N H N++ L+++
Sbjct: 24883 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 24941
Query: 170 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK 229
FES ++V++ E++ G ++F+RI ++ L E + + ++ Q+CE ++ +H I H D++
Sbjct: 24942 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 25001
Query: 230 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSV 289
PENI+ R + IKII+FG AR+ KP + ++ F PE+ APEV +D VS TDMWS+
Sbjct: 25002 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 25061
Query: 290 GVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWR 349
G + Y+LLSG++PFL + + + + NI+ + ++E F++IS EA +F+ +LL+KE+ R
Sbjct: 25062 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 25121
Query: 350 ISASEALKHPWL 361
++ASEAL+HPWL
Sbjct: 25122 MTASEALQHPWL 25133
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 229 bits (583), Expect = 4e-60
Identities = 105/252 (41%), Positives = 171/252 (67%), Gaps = 1/252 (0%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 169
E LG G FG VH+C ET++ AK +K +G D+ VK EIS++N H N++ L+++
Sbjct: 24758 EDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT-DQVLVKKEISILNIARHRNILHLHES 24816
Query: 170 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLK 229
FES ++V++ E++ G ++F+RI ++ L E + + ++ Q+CE ++ +H I H D++
Sbjct: 24817 FESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIR 24876
Query: 230 PENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSV 289
PENI+ R + IKII+FG AR+ KP + ++ F PE+ APEV +D VS TDMWS+
Sbjct: 24877 PENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSL 24936
Query: 290 GVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWR 349
G + Y+LLSG++PFL + + + + NI+ + ++E F++IS EA +F+ +LL+KE+ R
Sbjct: 24937 GTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 24996
Query: 350 ISASEALKHPWL 361
++ASEAL+HPWL
Sbjct: 24997 MTASEALQHPWL 25008
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 221 bits (562), Expect = 1e-57
Identities = 122/287 (42%), Positives = 175/287 (60%), Gaps = 15/287 (5%)
Query: 89 DHRIVTAK-QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE 147
D+R VT + V+ FY + E LG G+FGQV + E T A K K K+KE
Sbjct: 1448 DYRTVTINTEQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN 1505
Query: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207
++ EIS+MN L H L+Q DAFE K +IV+V+E V GGELF+RIIDE + LTE + I +
Sbjct: 1506 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1565
Query: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
M+QI EG+ ++H+ I+HLDLKPENI+CVN+ +IK+IDFGLARR + LKV FGTP
Sbjct: 1566 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTP 1625
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APEV+NY+ + + TDMWS+GVI Y+L + L W ++D +
Sbjct: 1626 EFVAPEVINYEPIGYATDMWSIGVICYIL-----------NRLDCTQCLQHPWLMKDTKN 1674
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK 374
+ + +K+ + K + + K W+ + + LS + S L+ +K
Sbjct: 1675 MEAKKLSKDRMKKYMARRK-WQKTGNAVRAIGRLSSMAMISGLSGRK 1720
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 221 bits (562), Expect = 1e-57
Identities = 122/287 (42%), Positives = 175/287 (60%), Gaps = 15/287 (5%)
Query: 89 DHRIVTAK-QGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE 147
D+R VT + V+ FY + E LG G+FGQV + E T A K K K+KE
Sbjct: 1379 DYRTVTINTEQKVSDFYDIE--ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN 1436
Query: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207
++ EIS+MN L H L+Q DAFE K +IV+V+E V GGELF+RIIDE + LTE + I +
Sbjct: 1437 IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1496
Query: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
M+QI EG+ ++H+ I+HLDLKPENI+CVN+ +IK+IDFGLARR + LKV FGTP
Sbjct: 1497 MRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTP 1556
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
EF+APEV+NY+ + + TDMWS+GVI Y+L + L W ++D +
Sbjct: 1557 EFVAPEVINYEPIGYATDMWSIGVICYIL-----------NRLDCTQCLQHPWLMKDTKN 1605
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQK 374
+ + +K+ + K + + K W+ + + LS + S L+ +K
Sbjct: 1606 MEAKKLSKDRMKKYMARRK-WQKTGNAVRAIGRLSSMAMISGLSGRK 1651
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 209 bits (533), Expect = 3e-54
Identities = 114/293 (38%), Positives = 178/293 (60%), Gaps = 10/293 (3%)
Query: 84 PPAPFDHRIVTAKQGAVNSF-----YTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIK 138
PP P ++T + V + Y++ LG G+F V KC + +G + AAK ++
Sbjct: 34 PPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMR 93
Query: 139 TR--GMKDKEEVKNEISVMNQL-DHANLIQLYDAFESKNDIVLVMEYVDGGELFDRII-D 194
R G + E+ +EI+V+ D+ +I L++ +E+ ++++LV+EY GGE+FD+ + D
Sbjct: 94 KRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVAD 153
Query: 195 ESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAK-QIKIIDFGLARR 253
E D M+QI EG+ +H ++HLDLKP+NIL + IKI+DFGL+R
Sbjct: 154 REEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRI 213
Query: 254 YKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLN 313
K E+L+ GTPE++APE+++YD +S TDMWS+GV+ Y++L+G+SPFLG++ ET
Sbjct: 214 LKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFL 273
Query: 314 NILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKL 366
NI +EEF +SE A +FI LL+K+ R +A E LKHPWL+ +
Sbjct: 274 NISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSI 326
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 202 bits (515), Expect = 3e-52
Identities = 106/275 (38%), Positives = 169/275 (61%), Gaps = 8/275 (2%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE-VKNEISVMNQLDHANLIQLYD 168
E LG G F +V EE ATG A K I + +K KE ++NEI+V+ ++ H N++ L D
Sbjct: 27 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86
Query: 169 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDL 228
+ES N + LVM+ V GGELFDRI+++ + TE D ++Q+ + + ++H+M I+H DL
Sbjct: 87 IYESPNHLYLVMQLVSGGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145
Query: 229 KPENILCVNRDAK-QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW 287
KPEN+L ++D + +I I DFGL++ + + GTP ++APEV+ S D W
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCW 205
Query: 288 SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKS 347
S+GVIAY+LL G PF +ND++ IL ++ + + DIS+ AK+FI L+ K+ +
Sbjct: 206 SIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPN 265
Query: 348 WRISASEALKHPWLS-----DHKLHSRLNAQKKKN 377
R + +A +HPW++ + +H ++AQ +KN
Sbjct: 266 KRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 202 bits (515), Expect = 3e-52
Identities = 106/275 (38%), Positives = 169/275 (61%), Gaps = 8/275 (2%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE-VKNEISVMNQLDHANLIQLYD 168
E LG G F +V EE ATG A K I + +K KE ++NEI+V+ ++ H N++ L D
Sbjct: 27 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86
Query: 169 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDL 228
+ES N + LVM+ V GGELFDRI+++ + TE D ++Q+ + + ++H+M I+H DL
Sbjct: 87 IYESPNHLYLVMQLVSGGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145
Query: 229 KPENILCVNRDAK-QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW 287
KPEN+L ++D + +I I DFGL++ + + GTP ++APEV+ S D W
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCW 205
Query: 288 SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKS 347
S+GVIAY+LL G PF +ND++ IL ++ + + DIS+ AK+FI L+ K+ +
Sbjct: 206 SIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPN 265
Query: 348 WRISASEALKHPWLS-----DHKLHSRLNAQKKKN 377
R + +A +HPW++ + +H ++AQ +KN
Sbjct: 266 KRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
>gi|4758194 serine/threonine kinase 17B [Homo sapiens]
Length = 372
Score = 200 bits (509), Expect = 2e-51
Identities = 112/297 (37%), Positives = 177/297 (59%), Gaps = 7/297 (2%)
Query: 93 VTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTR--GMKDKEEVKN 150
+ K N+FY ++ E LG G+F V +C +TG + AAK +K R G + E+ +
Sbjct: 21 IPIKMENFNNFYILTSKE-LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILH 79
Query: 151 EISVMNQLDHA-NLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNL-TELDTILFM 208
EI+V+ +I L++ +E+ ++I+L++EY GGE+F + E + +E D I +
Sbjct: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139
Query: 209 KQICEGIRHMHQMYILHLDLKPENILCVN-RDAKQIKIIDFGLARRYKPREKLKVNFGTP 267
KQI EG+ ++HQ I+HLDLKP+NIL + IKI+DFG++R+ +L+ GTP
Sbjct: 140 KQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTP 199
Query: 268 EFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEF 327
E+LAPE++NYD ++ TDMW++G+IAYMLL+ SPF+G+++ ET NI D +E F
Sbjct: 200 EYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETF 259
Query: 328 QDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQKKKNRGSDAQD 384
+S+ A +FI LL+K R +A L H WL + + ++ + S QD
Sbjct: 260 SSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSS-SSQTQD 315
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 194 bits (492), Expect = 1e-49
Identities = 103/275 (37%), Positives = 164/275 (59%), Gaps = 8/275 (2%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKE-EVKNEISVMNQLDHANLIQLYD 168
++LG G F +V E+ T +A K I ++ KE ++NEI+V++++ H N++ L D
Sbjct: 24 DVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDD 83
Query: 169 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDL 228
+ES + L+M+ V GGELFDRI+++ + TE D + Q+ + ++++H + I+H DL
Sbjct: 84 IYESGGHLYLIMQLVSGGELFDRIVEKGF-YTERDASRLIFQVLDAVKYLHDLGIVHRDL 142
Query: 229 KPENILCVNRDA-KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMW 287
KPEN+L + D +I I DFGL++ P L GTP ++APEV+ S D W
Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCW 202
Query: 288 SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKS 347
S+GVIAY+LL G PF +NDA+ IL ++ + + DIS+ AK+FI L+ K+
Sbjct: 203 SIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPE 262
Query: 348 WRISASEALKHPWLS-----DHKLHSRLNAQKKKN 377
R + +AL+HPW++ D +H ++ Q KKN
Sbjct: 263 KRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKN 297
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 182 bits (463), Expect = 3e-46
Identities = 113/313 (36%), Positives = 172/313 (54%), Gaps = 14/313 (4%)
Query: 84 PPAPFDHRIVTAKQGAVNSFYTVSKTEI---LGGGRFGQVHKCEETATGLKLAAKIIKTR 140
PP+ R AK A +K +I +G G F +V + E AT A K+I+T+
Sbjct: 73 PPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETK 132
Query: 141 GMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLT 200
+ +E ++E+ V+ ++ HAN+IQL + FE++ + +VME GGELFDRII + + T
Sbjct: 133 YREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKG-SFT 191
Query: 201 ELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA-KQIKIIDFGLARRYKPREK 259
E D ++ + +G+R++H + I H DLKPEN+L + +I I DFGLA K +
Sbjct: 192 ERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDD 251
Query: 260 --LKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILA 317
+K GTPE++APEV+ + DMW++GVIAY+LLSG PF DN IL
Sbjct: 252 CLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILR 311
Query: 318 CRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL-------SDHKLHSRL 370
++ E + +S AK+FI +LL + R++A +AL+HPW+ S LH +
Sbjct: 312 GKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSI 371
Query: 371 NAQKKKNRGSDAQ 383
+ K S Q
Sbjct: 372 SQNLLKRASSRCQ 384
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 179 bits (455), Expect = 3e-45
Identities = 112/314 (35%), Positives = 181/314 (57%), Gaps = 20/314 (6%)
Query: 49 SGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSK 108
+ N A EV A+L V S +T A+++ DHR ++ FY + +
Sbjct: 1558 TAQNLAGEVSCKAELA----VHSAQT---AMEVEGVGEDEDHR-----GRRLSDFYDIHQ 1605
Query: 109 TEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYD 168
+G G F + + E ++GL+ AAK I ++ K K + E ++ +L H ++ ++
Sbjct: 1606 E--IGRGAFSYLRRIVERSSGLEFAAKFIPSQA-KPKASARREARLLARLQHDCVLYFHE 1662
Query: 169 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDL 228
AFE + +V+V E EL +RI + + E + +M+Q+ EGI ++HQ ++LHLD+
Sbjct: 1663 AFERRRGLVIVTELCTE-ELLERIARKP-TVCESEIRAYMRQVLEGIHYLHQSHVLHLDV 1720
Query: 229 KPENILCVNRDA--KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDM 286
KPEN+L + A +Q++I DFG A+ P E +GTPEF+APE+VN VS TD+
Sbjct: 1721 KPENLLVWDGAAGEQQVRICDFGNAQELTPGEPQYCQYGTPEFVAPEIVNQSPVSGVTDI 1780
Query: 287 WSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEK 346
W VGV+A++ L+G+SPF+G+ND TL NI E+ F +S EA+ F+ K+L++++
Sbjct: 1781 WPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDR 1840
Query: 347 SWRISASEALKHPW 360
R +A E L+HPW
Sbjct: 1841 -LRPTAEETLEHPW 1853
Score = 150 bits (379), Expect = 2e-36
Identities = 94/272 (34%), Positives = 145/272 (53%), Gaps = 9/272 (3%)
Query: 94 TAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEIS 153
T +QG YT + + GRFG V C E ATG AKI+ + K V E
Sbjct: 2956 TLRQGPPQKPYTFLEEK--ARGRFGVVRACRENATGRTFVAKIVPYAA-EGKRRVLQEYE 3012
Query: 154 VMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICE 213
V+ L H ++ L++A+ + +VL+ E EL + D + +E D +M Q+ +
Sbjct: 3013 VLRTLHHERIMSLHEAYITPRYLVLIAESCGNRELLCGLSDR-FRYSEDDVATYMVQLLQ 3071
Query: 214 GIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPR--EKLKVNFGTPEFLA 271
G+ ++H ++LHLD+KP+N+L +A +KI+DFG A+ Y P+ L GT EF+A
Sbjct: 3072 GLDYLHGHHVLHLDIKPDNLLLAPDNA--LKIVDFGSAQPYNPQALRPLGHRTGTLEFMA 3129
Query: 272 PEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDIS 331
PE+V + + TD+W GV+ Y++LSG SPF + ET I+ R+D + + + S
Sbjct: 3130 PEMVKGEPIGSATDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFD-AFQLYPNTS 3188
Query: 332 EEAKEFISKLLIKEKSWRISASEALKHPWLSD 363
+ A F+ K+L R S + L HPWL D
Sbjct: 3189 QSATLFLRKVLSVHPWSRPSLQDCLAHPWLQD 3220
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 179 bits (454), Expect = 4e-45
Identities = 97/254 (38%), Positives = 153/254 (60%), Gaps = 4/254 (1%)
Query: 111 ILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAF 170
++G G F +V + E+ T A K+++TR + +E +E+SV+ ++ H ++QL + F
Sbjct: 68 LIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACVSELSVLRRVSHRYIVQLMEIF 127
Query: 171 ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKP 230
E+++ + +VME GGELFDR+I + + TE D + ++ + +GIR++H + I H +LKP
Sbjct: 128 ETEDQVYMVMELATGGELFDRLIAQG-SFTERDAVRILQMVADGIRYLHALQITHRNLKP 186
Query: 231 ENILCVNR-DAKQIKIIDFGLARRYKPREK--LKVNFGTPEFLAPEVVNYDFVSFPTDMW 287
EN+L + + +I I DFGLA K +K GTPE++APEV+ + DMW
Sbjct: 187 ENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTSAVDMW 246
Query: 288 SVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKS 347
++GVI Y LLSG PF ++ IL +++ E + IS AK+FI KLLI E
Sbjct: 247 ALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLLILEAG 306
Query: 348 WRISASEALKHPWL 361
R+SA +AL HPW+
Sbjct: 307 HRMSAGQALDHPWV 320
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 176 bits (446), Expect = 3e-44
Identities = 96/257 (37%), Positives = 149/257 (57%), Gaps = 5/257 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + G + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 17 EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 76
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + L+ + V GGELF+ I+ Y +E D ++QI E + H HQM ++H D
Sbjct: 77 DSISEEGHHYLIFDLVTGGELFEDIVAREY-YSEADASHCIQQILEAVLHCHQMGVVHRD 135
Query: 228 LKPENILCVNR-DAKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 195
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
+W+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 196 LWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 255
Query: 346 KSWRISASEALKHPWLS 362
S RI+A+EALKHPW+S
Sbjct: 256 PSKRITAAEALKHPWIS 272
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 176 bits (446), Expect = 3e-44
Identities = 96/257 (37%), Positives = 149/257 (57%), Gaps = 5/257 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + G + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 17 EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 76
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + L+ + V GGELF+ I+ Y +E D ++QI E + H HQM ++H D
Sbjct: 77 DSISEEGHHYLIFDLVTGGELFEDIVAREY-YSEADASHCIQQILEAVLHCHQMGVVHRD 135
Query: 228 LKPENILCVNR-DAKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 195
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
+W+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 196 LWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 255
Query: 346 KSWRISASEALKHPWLS 362
S RI+A+EALKHPW+S
Sbjct: 256 PSKRITAAEALKHPWIS 272
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 174 bits (440), Expect = 2e-43
Identities = 103/262 (39%), Positives = 153/262 (58%), Gaps = 5/262 (1%)
Query: 101 NSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDH 160
+SFY S+ LG GRF V KC++ T +A K + + MK +++V +E+ ++ L H
Sbjct: 2793 DSFY--SEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-RDQVTHELGILQSLQH 2849
Query: 161 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQ 220
L+ L D FE+ +LV+E D G L D ++ +LTE + ++ E +R++H
Sbjct: 2850 PLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWG-SLTEGKIRAHLGEVLEAVRYLHN 2908
Query: 221 MYILHLDLKPENILCVNRDAKQ-IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDF 279
I HLDLKPENIL AK IK+ DFG A + + G PEF APE++ +
Sbjct: 2909 CRIAHLDLKPENILVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNP 2968
Query: 280 VSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFIS 339
VS +D WSVGV+ Y+LLSG+SPFL D+ ET NI + D+ F+ +S++AKEF+
Sbjct: 2969 VSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVC 3028
Query: 340 KLLIKEKSWRISASEALKHPWL 361
LL ++ + R SA+ AL+ WL
Sbjct: 3029 FLLQEDPAKRPSAALALQEQWL 3050
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 172 bits (436), Expect = 5e-43
Identities = 97/256 (37%), Positives = 147/256 (57%), Gaps = 5/256 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + TG + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + LV + V GGELF+ I+ Y +E D ++QI E + H H I+H D
Sbjct: 78 DSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCHLNGIVHRD 136
Query: 228 LKPENILCVNRD-AKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
MW+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 197 MWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 256
Query: 346 KSWRISASEALKHPWL 361
+ RI+ASEALKHPW+
Sbjct: 257 PAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 172 bits (436), Expect = 5e-43
Identities = 97/256 (37%), Positives = 147/256 (57%), Gaps = 5/256 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + TG + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + LV + V GGELF+ I+ Y +E D ++QI E + H H I+H D
Sbjct: 78 DSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCHLNGIVHRD 136
Query: 228 LKPENILCVNRD-AKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
MW+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 197 MWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 256
Query: 346 KSWRISASEALKHPWL 361
+ RI+ASEALKHPW+
Sbjct: 257 PAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 172 bits (436), Expect = 5e-43
Identities = 97/256 (37%), Positives = 147/256 (57%), Gaps = 5/256 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + TG + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + LV + V GGELF+ I+ Y +E D ++QI E + H H I+H D
Sbjct: 78 DSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCHLNGIVHRD 136
Query: 228 LKPENILCVNRD-AKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
MW+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 197 MWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 256
Query: 346 KSWRISASEALKHPWL 361
+ RI+ASEALKHPW+
Sbjct: 257 PAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 172 bits (436), Expect = 5e-43
Identities = 97/256 (37%), Positives = 147/256 (57%), Gaps = 5/256 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + TG + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + LV + V GGELF+ I+ Y +E D ++QI E + H H I+H D
Sbjct: 78 DSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCHLNGIVHRD 136
Query: 228 LKPENILCVNRD-AKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
MW+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 197 MWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 256
Query: 346 KSWRISASEALKHPWL 361
+ RI+ASEALKHPW+
Sbjct: 257 PAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 172 bits (436), Expect = 5e-43
Identities = 97/256 (37%), Positives = 147/256 (57%), Gaps = 5/256 (1%)
Query: 110 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGM--KDKEEVKNEISVMNQLDHANLIQLY 167
E LG G F V +C + TG + AAKII T+ + +D ++++ E + L H N+++L+
Sbjct: 18 EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLH 77
Query: 168 DAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLD 227
D+ + LV + V GGELF+ I+ Y +E D ++QI E + H H I+H D
Sbjct: 78 DSISEEGFHYLVFDLVTGGELFEDIVAREY-YSEADASHCIQQILESVNHCHLNGIVHRD 136
Query: 228 LKPENILCVNRD-AKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYDFVSFPTD 285
LKPEN+L ++ +K+ DFGLA + ++ F GTP +L+PEV+ D P D
Sbjct: 137 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVD 196
Query: 286 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 345
MW+ GVI Y+LL G PF ++ I A +D E+ ++ EAK+ I+K+L
Sbjct: 197 MWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTIN 256
Query: 346 KSWRISASEALKHPWL 361
+ RI+ASEALKHPW+
Sbjct: 257 PAKRITASEALKHPWI 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,989,044
Number of Sequences: 37866
Number of extensions: 594214
Number of successful extensions: 4187
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 599
Number of HSP's successfully gapped in prelim test: 196
Number of HSP's that attempted gapping in prelim test: 1685
Number of HSP's gapped (non-prelim): 978
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.