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Search of human proteins with 15451916
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15451916 bone morphogenetic protein receptor type II
precursor [Homo sapiens]
(1038 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15451916 bone morphogenetic protein receptor type II precurso... 2105 0.0
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 289 8e-78
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 286 7e-77
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 286 9e-77
gi|67782324 transforming growth factor, beta receptor II isoform... 230 5e-60
gi|67782326 transforming growth factor, beta receptor II isoform... 230 5e-60
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 218 3e-56
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 206 1e-52
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 206 1e-52
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 203 6e-52
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 197 6e-50
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 197 6e-50
gi|4759226 transforming growth factor, beta receptor I isoform 1... 196 7e-50
gi|195963412 transforming growth factor, beta receptor I isoform... 196 7e-50
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 194 5e-49
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 187 6e-47
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 182 1e-45
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 182 1e-45
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 179 9e-45
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 157 5e-38
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 146 9e-35
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 91 6e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 86 1e-16
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 86 1e-16
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 83 2e-15
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 83 2e-15
gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog [... 80 8e-15
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 80 1e-14
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 76 2e-13
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 76 2e-13
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 2105 bits (5454), Expect = 0.0
Identities = 1038/1038 (100%), Positives = 1038/1038 (100%)
Query: 1 MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILC 60
MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILC
Sbjct: 1 MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILC 60
Query: 61 SKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCST 120
SKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCST
Sbjct: 61 SKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCST 120
Query: 121 DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK 180
DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK
Sbjct: 121 DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK 180
Query: 181 QGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNF 240
QGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNF
Sbjct: 181 QGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNF 240
Query: 241 INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS 300
INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS
Sbjct: 241 INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS 300
Query: 301 SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG 360
SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG
Sbjct: 301 SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG 360
Query: 361 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 420
NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC
Sbjct: 361 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 420
Query: 421 TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI 480
TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI
Sbjct: 421 TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI 480
Query: 481 EDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKI 540
EDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKI
Sbjct: 481 EDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKI 540
Query: 541 GPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPS 600
GPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPS
Sbjct: 541 GPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPS 600
Query: 601 PETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTE 660
PETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTE
Sbjct: 601 PETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTE 660
Query: 661 EDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQ 720
EDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQ
Sbjct: 661 EDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQ 720
Query: 721 QDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSN 780
QDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSN
Sbjct: 721 QDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSN 780
Query: 781 LKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVT 840
LKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVT
Sbjct: 781 LKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVT 840
Query: 841 HRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRT 900
HRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRT
Sbjct: 841 HRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRT 900
Query: 901 NSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGEST 960
NSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGEST
Sbjct: 901 NSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGEST 960
Query: 961 QDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLA 1020
QDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLA
Sbjct: 961 QDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLA 1020
Query: 1021 EGGTATTMVSKDIGMNCL 1038
EGGTATTMVSKDIGMNCL
Sbjct: 1021 EGGTATTMVSKDIGMNCL 1038
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 289 bits (740), Expect = 8e-78
Identities = 178/502 (35%), Positives = 271/502 (53%), Gaps = 37/502 (7%)
Query: 12 PWLPWTILLVSTAAASQNQE---RLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYG 68
PW+ +L S A S E R C + + + +S + G K CY
Sbjct: 4 PWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQ--DKRLHCYA 61
Query: 69 LWEKSKGDINLVKQGCWSHIGDPQECH-YEECVVTTTPPSIQNGTYRFCCCSTDLCNVNF 127
W S G I LVK+GCW D C+ +ECV T P + FCCC + CN F
Sbjct: 62 SWRNSSGTIELVKKGCWL---DDFNCYDRQECVATEENPQVY-----FCCCEGNFCNERF 113
Query: 128 TE--NFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHS 185
T P+ T PP + + +L + L+++++ + YR RK
Sbjct: 114 THLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR----HRKPPYGH 169
Query: 186 MNMMEAAASEPSLDLDNLK---LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFIN 242
+++ E P L LK LLE+ RGR+G V+K L VAVK+F ++Q++ +
Sbjct: 170 VDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQS 229
Query: 243 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSC 302
E+ I+ P M+H+N+ +FI ++R ++ +E L+ ++ GSL YL + W C
Sbjct: 230 EREIFSTPGMKHENLLQFIAAEKR-GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELC 288
Query: 303 RLAHSVTRGLAYLHTELP--RGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG 360
+A +++RGL+YLH ++P RG+ +KP+I+HRD S+NVL+K+D T V++DFGL++R
Sbjct: 289 HVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF-- 346
Query: 361 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 420
PG+ +VGT RYMAPEVLEGA+N + A ++DMYA+GL+ WE+ RC
Sbjct: 347 ----EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELVSRC 400
Query: 421 TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI 480
V EY + F+ E+G HP+ E++Q +V +K RP + W ++ + L TI
Sbjct: 401 K--AADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHP-GLAQLCVTI 457
Query: 481 EDCWDQDAEARLTAQCAEERMA 502
E+CWD DAEARL+A C EER++
Sbjct: 458 EECWDHDAEARLSAGCVEERVS 479
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 286 bits (732), Expect = 7e-77
Identities = 166/450 (36%), Positives = 255/450 (56%), Gaps = 32/450 (7%)
Query: 66 CYGLWEKSKGDINLVKQGCWSHIGDPQECHYE-ECVVTTTPPSIQNGTYRFCCCSTDLCN 124
C+ W+ G I +VKQGCW D C+ +CV P + FCCC ++CN
Sbjct: 60 CFATWKNISGSIEIVKQGCWL---DDINCYDRTDCVEKKDSPEVY-----FCCCEGNMCN 111
Query: 125 VNFTENFPP-----PDTTPLSP-PHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGD 178
F+ FP P + P++P P +N ++ +L + ++A +++ + YR
Sbjct: 112 EKFSY-FPEMEVTQPTSNPVTPKPPYYN---ILLYSLVPLMLIAGIVICAFWVYRHHKMA 167
Query: 179 RKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQ 238
L P L L L+LLE+ RGR+G V+K L VAVK+F ++Q
Sbjct: 168 YPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQ 227
Query: 239 NFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDW 298
++ NE +Y +P M+H+NI +FI ++R T+ ++ L+ ++ GSL +L + W
Sbjct: 228 SWQNEYEVYSLPGMKHENILQFIGAEKRGTSVD-VDLWLITAFHEKGSLSDFLKANVVSW 286
Query: 299 VSSCRLAHSVTRGLAYLHTELP-RGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMR 357
C +A ++ RGLAYLH ++P D +KPAISHRD+ S+NVL+KN+ T I+DFGL+++
Sbjct: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346
Query: 358 LTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 417
G+ +VGT RYMAPEVLEGA+N + A ++DMYA+GL+ WE+
Sbjct: 347 F------EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELA 398
Query: 418 MRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLK 477
RCT V EY + F+ E+G HP+ EDMQ +V +K+RP + W++++ + L
Sbjct: 399 SRCT--AADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLC 455
Query: 478 ETIEDCWDQDAEARLTAQCAEERMAELMMI 507
ETIE+CWD DAEARL+A C ER+ ++ +
Sbjct: 456 ETIEECWDHDAEARLSAGCVGERITQMQRL 485
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 286 bits (731), Expect = 9e-77
Identities = 167/461 (36%), Positives = 252/461 (54%), Gaps = 19/461 (4%)
Query: 58 ILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCC 117
I C C+G+W ++ + QGC D C C + T C
Sbjct: 53 IRCLYSRCCFGIWNLTQDRAQVEMQGCRD--SDEPGCESLHCDPSPRAHPSPGSTLFTCS 110
Query: 118 CSTDLCNVNFTENFPPPDT--TPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRML 175
C TD CN N++ + PPP + TP S E+I +AL + + +L++ L L
Sbjct: 111 CGTDFCNANYS-HLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILAL 169
Query: 176 TGDRKQGLHSMNMMEA---AASEPSLDLDNLKLL---ELIGRGRYGAVYKGSLDERPVAV 229
+ + + E + + S++L L L ++I G + V+ G L + VA+
Sbjct: 170 LQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAI 229
Query: 230 KVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCK 289
K F + F E+ +Y +P ++HD+I RFI LLV+E +P GSLC
Sbjct: 230 KAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCH 289
Query: 290 YLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVI 349
YL+ +TSDW SS R+A S+ +GLA+LH E + YKP I+HRDL+S+NVL++ DG+C I
Sbjct: 290 YLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAI 349
Query: 350 SDFGLSMRLTGNRLVRPGE------EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQ 403
D GL++ L G L +P + AAI E GT RYMAPE+L+ ++L+D AL++
Sbjct: 350 GDLGLALVLPG--LTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRR 407
Query: 404 VDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFP 463
D+Y+L L+ WEI RC DL P S P +Q+A++ E+GN PT +++ L +E++RP P
Sbjct: 408 ADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIP 467
Query: 464 EAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
W+ + L+E +EDCWD D EARLTA+C ++R+A L
Sbjct: 468 STWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAAL 508
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 230 bits (587), Expect = 5e-60
Identities = 167/521 (32%), Positives = 261/521 (50%), Gaps = 76/521 (14%)
Query: 32 RLCAFKDPYQQDLGIGESRISHENGTILCSKGS-TCYGLWEKSKGDINLVKQGCWSHIGD 90
+LC F D +S +S+ + T +C K C +W K+ +I L + D
Sbjct: 49 QLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLE-----TVCHD 103
Query: 91 PQECHYEECVVTTTPPSI-------QNGTYRFCCCSTDLCNVN--FTENFPPPDTTPLSP 141
P+ +++ + P T+ C CS+D CN N F+E + + L
Sbjct: 104 PKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLL-- 161
Query: 142 PHSFNRDETIIIALASVSVL-----AVLIVALCFGYRMLTGDRKQGL------------- 183
+I + +S+L A+ ++ + + YR+ +R+Q L
Sbjct: 162 --------LVIFQVTGISLLPPLGVAISVIIIFYCYRV---NRQQKLSSTWETGKTRKLM 210
Query: 184 ----HSMNMMEAAASEPSLDLDN----------LKLLELIGRGRYGAVYKGSLDERP--- 226
H ++E S+ S N ++L L+G+GR+ VYK L +
Sbjct: 211 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ 270
Query: 227 ---VAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYP 283
VAVK+F + ++ EK+I+ ++H+NI +F+ +ER T G+ +Y L+ ++
Sbjct: 271 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGK-QYWLITAFHA 329
Query: 284 NGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKN 343
G+L +YL+ H W +L S+ RG+A+LH++ K I HRDL S N+LVKN
Sbjct: 330 KGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN 389
Query: 344 DGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQ 403
D TC + DFGLS+RL V +D A +VGT RYMAPEVLE +NL + ES KQ
Sbjct: 390 DLTCCLCDFGLSLRLDPTLSV----DDLANSGQVGTARYMAPEVLESRMNLENVES-FKQ 444
Query: 404 VDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFP 463
D+Y++ L+ WE+ RC + GE V +Y+ F ++V HP E M+ V R++ RP+ P
Sbjct: 445 TDVYSMALVLWEMTSRCNAV--GE-VKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIP 501
Query: 464 EAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
W N ++ + ET+ +CWD D EARLTAQC ER +EL
Sbjct: 502 SFWL-NHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 230 bits (587), Expect = 5e-60
Identities = 167/521 (32%), Positives = 261/521 (50%), Gaps = 76/521 (14%)
Query: 32 RLCAFKDPYQQDLGIGESRISHENGTILCSKGS-TCYGLWEKSKGDINLVKQGCWSHIGD 90
+LC F D +S +S+ + T +C K C +W K+ +I L + D
Sbjct: 74 QLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLE-----TVCHD 128
Query: 91 PQECHYEECVVTTTPPSI-------QNGTYRFCCCSTDLCNVN--FTENFPPPDTTPLSP 141
P+ +++ + P T+ C CS+D CN N F+E + + L
Sbjct: 129 PKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLL-- 186
Query: 142 PHSFNRDETIIIALASVSVL-----AVLIVALCFGYRMLTGDRKQGL------------- 183
+I + +S+L A+ ++ + + YR+ +R+Q L
Sbjct: 187 --------LVIFQVTGISLLPPLGVAISVIIIFYCYRV---NRQQKLSSTWETGKTRKLM 235
Query: 184 ----HSMNMMEAAASEPSLDLDN----------LKLLELIGRGRYGAVYKGSLDERP--- 226
H ++E S+ S N ++L L+G+GR+ VYK L +
Sbjct: 236 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ 295
Query: 227 ---VAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYP 283
VAVK+F + ++ EK+I+ ++H+NI +F+ +ER T G+ +Y L+ ++
Sbjct: 296 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGK-QYWLITAFHA 354
Query: 284 NGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKN 343
G+L +YL+ H W +L S+ RG+A+LH++ K I HRDL S N+LVKN
Sbjct: 355 KGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN 414
Query: 344 DGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQ 403
D TC + DFGLS+RL V +D A +VGT RYMAPEVLE +NL + ES KQ
Sbjct: 415 DLTCCLCDFGLSLRLDPTLSV----DDLANSGQVGTARYMAPEVLESRMNLENVES-FKQ 469
Query: 404 VDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFP 463
D+Y++ L+ WE+ RC + GE V +Y+ F ++V HP E M+ V R++ RP+ P
Sbjct: 470 TDVYSMALVLWEMTSRCNAV--GE-VKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIP 526
Query: 464 EAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
W N ++ + ET+ +CWD D EARLTAQC ER +EL
Sbjct: 527 SFWL-NHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 218 bits (554), Expect = 3e-56
Identities = 152/470 (32%), Positives = 230/470 (48%), Gaps = 45/470 (9%)
Query: 59 LCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCC 118
+CS C+ + E+ + +V GC G +C TP Q + CC
Sbjct: 46 ICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCR-------DTPIPHQRRSIE-CCT 97
Query: 119 STDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALC-FGY-RMLT 176
+ CN + PP +R ++I++ S+L VLI+ C F Y R T
Sbjct: 98 ERNECNKDLHPTLPPLKNRDFVDGPIHHR--ALLISVTVCSLLLVLIILFCYFRYKRQET 155
Query: 177 GDRKQ-GLHS--------------MNMMEAAASEPSLDL-------DNLKLLELIGRGRY 214
R GL + +++ S L L +++++ IG+GRY
Sbjct: 156 RPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRY 215
Query: 215 GAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRME 274
G V+ G VAVKVF ++ E IY+ LM H+NI FI D + T
Sbjct: 216 GEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 275
Query: 275 YLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDL 334
Y L+ +Y+ NGSL YL T D S +LA+S GL +LHTE+ KPAI+HRDL
Sbjct: 276 Y-LITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI-FSTQGKPAIAHRDL 333
Query: 335 NSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNL 394
S+N+LVK +GTC I+D GL+++ + E D + VGT RYM PEVL+ ++N
Sbjct: 334 KSKNILVKKNGTCCIADLGLAVKFISD----TNEVDIPPNTRVGTKRYMPPEVLDESLNR 389
Query: 395 RDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVS 454
+S + DMY+ GLI WE+ RC G V EYQ+ + V + P++EDM+ +V
Sbjct: 390 NHFQSYI-MADMYSFGLILWEVARRCVS---GGIVEEYQLPYHDLVPSDPSYEDMREIVC 445
Query: 455 REKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+K RP FP W + +R + + + +CW + +RLTA ++ +A++
Sbjct: 446 IKKLRPSFPNRWSSDE-CLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 494
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 206 bits (523), Expect = 1e-52
Identities = 151/468 (32%), Positives = 232/468 (49%), Gaps = 63/468 (13%)
Query: 62 KGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTT-TPPSIQNGTYRFCCCST 120
+G C+ + G ++ ++GC+ YE+ +T TPPS CC
Sbjct: 49 EGQQCFSSLSINDG-FHVYQKGCFQV--------YEQGKMTCKTPPSPGQAVE---CCQG 96
Query: 121 DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK 180
D CN N T P T S P + N + + + SV V AV ++A G + R+
Sbjct: 97 DWCNRNITAQLP---TKGKSFPGTQNFHLEVGLIILSV-VFAVCLLACLLGVALRKFKRR 152
Query: 181 ---------------QGLHSMNMMEAAASEPSLDLD-------------------NLKLL 206
+GL + N+ ++ ++ LD + LL
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLAD-LLDHSCTSGSGSGLPFLVQRTVARQITLL 211
Query: 207 ELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDER 266
E +G+GRYG V++GS VAVK+FS + +++ E +Y ++ H+NI FI D
Sbjct: 212 ECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD-M 270
Query: 267 VTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYK 326
+ + L+ Y+ GSL YL L T D VS R+ S+ GLA+LH E+ G K
Sbjct: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI-FGTQGK 329
Query: 327 PAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPE 386
PAI+HRDL S+N+LVK +G C I+D GL++ + + + D VGT RYMAPE
Sbjct: 330 PAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS----TNQLDVGNNPRVGTKRYMAPE 385
Query: 387 VLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTF 446
VL+ + + DC + K+VD++A GL+ WE+ R + V +Y+ F V N P+F
Sbjct: 386 VLDETIQV-DCFDSYKRVDIWAFGLVLWEVARR---MVSNGIVEDYKPPFYDVVPNDPSF 441
Query: 447 EDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTA 494
EDM+ +V ++QRP P W + + SL + +++CW Q+ ARLTA
Sbjct: 442 EDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECWYQNPSARLTA 488
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 206 bits (523), Expect = 1e-52
Identities = 151/468 (32%), Positives = 232/468 (49%), Gaps = 63/468 (13%)
Query: 62 KGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTT-TPPSIQNGTYRFCCCST 120
+G C+ + G ++ ++GC+ YE+ +T TPPS CC
Sbjct: 49 EGQQCFSSLSINDG-FHVYQKGCFQV--------YEQGKMTCKTPPSPGQAVE---CCQG 96
Query: 121 DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK 180
D CN N T P T S P + N + + + SV V AV ++A G + R+
Sbjct: 97 DWCNRNITAQLP---TKGKSFPGTQNFHLEVGLIILSV-VFAVCLLACLLGVALRKFKRR 152
Query: 181 ---------------QGLHSMNMMEAAASEPSLDLD-------------------NLKLL 206
+GL + N+ ++ ++ LD + LL
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLAD-LLDHSCTSGSGSGLPFLVQRTVARQITLL 211
Query: 207 ELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDER 266
E +G+GRYG V++GS VAVK+FS + +++ E +Y ++ H+NI FI D
Sbjct: 212 ECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD-M 270
Query: 267 VTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYK 326
+ + L+ Y+ GSL YL L T D VS R+ S+ GLA+LH E+ G K
Sbjct: 271 TSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI-FGTQGK 329
Query: 327 PAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPE 386
PAI+HRDL S+N+LVK +G C I+D GL++ + + + D VGT RYMAPE
Sbjct: 330 PAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS----TNQLDVGNNPRVGTKRYMAPE 385
Query: 387 VLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTF 446
VL+ + + DC + K+VD++A GL+ WE+ R + V +Y+ F V N P+F
Sbjct: 386 VLDETIQV-DCFDSYKRVDIWAFGLVLWEVARR---MVSNGIVEDYKPPFYDVVPNDPSF 441
Query: 447 EDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTA 494
EDM+ +V ++QRP P W + + SL + +++CW Q+ ARLTA
Sbjct: 442 EDMRKVVCVDQQRPNIPNRWFSDP-TLTSLAKLMKECWYQNPSARLTA 488
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 203 bits (517), Expect = 6e-52
Identities = 136/473 (28%), Positives = 228/473 (48%), Gaps = 50/473 (10%)
Query: 60 CSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCS 119
C C+ + E+ + GC + G +C +P + T CC
Sbjct: 76 CITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCK-------DSPKAQLRRTIE--CCR 126
Query: 120 TDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYR------ 173
T+LCN PP + P + +++ +V ++A++I + CF Y+
Sbjct: 127 TNLCNQYLQPTLPP---VVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSI 183
Query: 174 ----------------MLTGDRKQGLHSMNMMEAAASEPSLDLDN-----LKLLELIGRG 212
+ G+ + L + + S L + ++++ +G+G
Sbjct: 184 SSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKG 243
Query: 213 RYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGR 272
RYG V+ G VAVKVF ++ E IY+ LM H+NI FI D + T
Sbjct: 244 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 303
Query: 273 MEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHR 332
Y L+ +Y+ NGSL +L T D + +LA+S GL +LHTE+ G KPAI+HR
Sbjct: 304 QLY-LITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEI-YGTQGKPAIAHR 361
Query: 333 DLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAV 392
DL S+N+L+K +G+C I+D GL+++ + E D + VGT RYMAPEVL+ ++
Sbjct: 362 DLKSKNILIKKNGSCCIADLGLAVKFNSD----TNEVDVPLNTRVGTKRYMAPEVLDESL 417
Query: 393 NLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVL 452
N + + D+Y+ GLI WE+ RC G V EYQ+ + V + P++EDM+ +
Sbjct: 418 NKNHFQPYI-MADIYSFGLIIWEMARRC---ITGGIVEEYQLPYYNMVPSDPSYEDMREV 473
Query: 453 VSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELM 505
V ++ RP W + +R++ + + +CW + +RLTA ++ +A+++
Sbjct: 474 VCVKRLRPIVSNRWNSDE-CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMV 525
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 197 bits (500), Expect = 6e-50
Identities = 136/417 (32%), Positives = 213/417 (51%), Gaps = 46/417 (11%)
Query: 117 CCSTDLCNVNFTENFPP--PDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRM 174
CC TD CN N T + P P+ L P I + + +S+ A+L V C G +
Sbjct: 36 CCFTDFCN-NITLHLPTASPNAPKLGP---MELAIIITVPVCLLSIAAMLTVWACQGRQC 91
Query: 175 LTGDRK-----QGLHSMNMMEAAASEPSLDLD--------------------NLKLLELI 209
+K + L N++ A + L D + L E++
Sbjct: 92 SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIV 151
Query: 210 GRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTA 269
G+GR+G V+ G VAVK+FS + +++ E IY+ ++ H+NI FI D +
Sbjct: 152 GKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNG 211
Query: 270 DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAI 329
+ LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G KPAI
Sbjct: 212 TW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQGKPAI 269
Query: 330 SHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRYMAPEV 387
+HRD+ S+N+LVK TC I+D GL+++ N + P +VGT RYMAPE+
Sbjct: 270 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRYMAPEM 323
Query: 388 LEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFE 447
L+ +N+ ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V + P+ E
Sbjct: 324 LDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPSDPSIE 379
Query: 448 DMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+M+ +V +K RP P W ++ A+R + + +CW + ARLTA ++ +++L
Sbjct: 380 EMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 197 bits (500), Expect = 6e-50
Identities = 136/417 (32%), Positives = 213/417 (51%), Gaps = 46/417 (11%)
Query: 117 CCSTDLCNVNFTENFPP--PDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRM 174
CC TD CN N T + P P+ L P I + + +S+ A+L V C G +
Sbjct: 86 CCFTDFCN-NITLHLPTASPNAPKLGP---MELAIIITVPVCLLSIAAMLTVWACQGRQC 141
Query: 175 LTGDRK-----QGLHSMNMMEAAASEPSLDLD--------------------NLKLLELI 209
+K + L N++ A + L D + L E++
Sbjct: 142 SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIV 201
Query: 210 GRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTA 269
G+GR+G V+ G VAVK+FS + +++ E IY+ ++ H+NI FI D +
Sbjct: 202 GKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNG 261
Query: 270 DGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAI 329
+ LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G KPAI
Sbjct: 262 TW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQGKPAI 319
Query: 330 SHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRYMAPEV 387
+HRD+ S+N+LVK TC I+D GL+++ N + P +VGT RYMAPE+
Sbjct: 320 AHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRYMAPEM 373
Query: 388 LEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFE 447
L+ +N+ ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V + P+ E
Sbjct: 374 LDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPSDPSIE 429
Query: 448 DMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+M+ +V +K RP P W ++ A+R + + +CW + ARLTA ++ +++L
Sbjct: 430 EMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 196 bits (499), Expect = 7e-50
Identities = 114/300 (38%), Positives = 176/300 (58%), Gaps = 11/300 (3%)
Query: 205 LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGD 264
L E IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 207 LQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD 266
Query: 265 ERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH 324
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 267 NKDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV-GTQ 324
Query: 325 YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMA 384
KPAI+HRDL S+N+LVK +GTC I+D GL++R D A VGT RYMA
Sbjct: 325 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS----ATDTIDIAPNHRVGTKRYMA 380
Query: 385 PEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHP 444
PEVL+ ++N++ ES K+ D+YA+GL++WEI RC+ G +YQ+ + V + P
Sbjct: 381 PEVLDDSINMKHFES-FKRADIYAMGLVFWEIARRCS---IGGIHEDYQLPYYDLVPSDP 436
Query: 445 TFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+ E+M+ +V +K RP P W ++ A+R + + + +CW + ARLTA ++ +++L
Sbjct: 437 SVEEMRKVVCEQKLRPNIPNRW-QSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 196 bits (499), Expect = 7e-50
Identities = 114/300 (38%), Positives = 176/300 (58%), Gaps = 11/300 (3%)
Query: 205 LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGD 264
L E IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 130 LQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD 189
Query: 265 ERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH 324
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 190 NKDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV-GTQ 247
Query: 325 YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMA 384
KPAI+HRDL S+N+LVK +GTC I+D GL++R D A VGT RYMA
Sbjct: 248 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS----ATDTIDIAPNHRVGTKRYMA 303
Query: 385 PEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHP 444
PEVL+ ++N++ ES K+ D+YA+GL++WEI RC+ G +YQ+ + V + P
Sbjct: 304 PEVLDDSINMKHFES-FKRADIYAMGLVFWEIARRCS---IGGIHEDYQLPYYDLVPSDP 359
Query: 445 TFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+ E+M+ +V +K RP P W ++ A+R + + + +CW + ARLTA ++ +++L
Sbjct: 360 SVEEMRKVVCEQKLRPNIPNRW-QSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 418
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 194 bits (492), Expect = 5e-49
Identities = 137/422 (32%), Positives = 205/422 (48%), Gaps = 53/422 (12%)
Query: 117 CCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVL--AVLIVALCFGYRM 174
CC TD CN P P + E + I V +L ++IV L Y
Sbjct: 95 CCYTDYCN-RIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQ 153
Query: 175 LTGDRKQGLHSMNMMEAAASEPSLDLDN-----------------------------LKL 205
+Q L ME + E L D + L
Sbjct: 154 RVYHNRQRLD----MEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL 209
Query: 206 LELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE 265
E+IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 210 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 269
Query: 266 RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHY 325
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 270 KDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV-GTQG 327
Query: 326 KPAISHRDLNSRNVLVKNDGTCVISDFGLSMR---LTGNRLVRPGEEDNAAISEVGTIRY 382
KP I+HRDL S+N+LVK +G C I+D GL++R +T + P + VGT RY
Sbjct: 328 KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ-------RVGTKRY 380
Query: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGN 442
MAPEVL+ +N++ +S K D+YALGL+YWEI RC G EYQ+ + V +
Sbjct: 381 MAPEVLDETINMKHFDS-FKCADIYALGLVYWEIARRCNS---GGVHEEYQLPYYDLVPS 436
Query: 443 HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMA 502
P+ E+M+ +V +K RP P W+ A+R + + + +CW + ARLTA ++ ++
Sbjct: 437 DPSIEEMRKVVCDQKLRPNIPNWWQSYE-ALRVMGKMMRECWYANGAARLTALRIKKTLS 495
Query: 503 EL 504
+L
Sbjct: 496 QL 497
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 187 bits (474), Expect = 6e-47
Identities = 111/302 (36%), Positives = 174/302 (57%), Gaps = 15/302 (4%)
Query: 205 LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGD 264
L E++G+GR+G V+ G VAVK+FS + +++ E IY+ ++ H+NI FI D
Sbjct: 117 LQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAAD 176
Query: 265 ERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH 324
+ + LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G
Sbjct: 177 NKDNGTW-TQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQ 234
Query: 325 YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRY 382
KPAI+HRD+ S+N+LVK TC I+D GL+++ N + P +VGT RY
Sbjct: 235 GKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRY 288
Query: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGN 442
MAPE+L+ +N+ ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V +
Sbjct: 289 MAPEMLDDTMNVNIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPS 344
Query: 443 HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMA 502
P+ E+M+ +V +K RP P W ++ A+R + + +CW + ARLTA ++ ++
Sbjct: 345 DPSIEEMRKVVCDQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTIS 403
Query: 503 EL 504
+L
Sbjct: 404 QL 405
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 182 bits (463), Expect = 1e-45
Identities = 153/493 (31%), Positives = 225/493 (45%), Gaps = 72/493 (14%)
Query: 62 KGSTCYGLW-----EKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFC 116
KG TC G W + +G +GC + H E C P N
Sbjct: 42 KGPTCRGAWCTVVLVREEGRHPQEHRGCGN-------LHRELC--RGRPTEFVN----HY 88
Query: 117 CCSTDLCNVNFT---ENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFG-- 171
CC + LCN N + E PP P D + + L V L L+ G
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPSEQP-------GTDGQLALILGPVLALLALVALGVLGLW 141
Query: 172 YRMLTGDRKQGLHSM---NMMEAAASEPS-------LDLD-------------------N 202
+ ++++GLHS + + ASE LD D
Sbjct: 142 HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQ 201
Query: 203 LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV 262
+ L+E +G+GRYG V++G VAVK+FS + Q++ E IY L+ HDNI FI
Sbjct: 202 VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 261
Query: 263 GDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG 322
D + + + L+ Y+ +GSL +L T + + RLA S GLA+LH E+ G
Sbjct: 262 SD-MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI-FG 319
Query: 323 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS-MRLTGNRLVRPGEEDNAAISEVGTIR 381
KPAI+HRD SRNVLVK++ C I+D GL+ M G+ + G VGT R
Sbjct: 320 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN-----PRVGTKR 374
Query: 382 YMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVG 441
YMAPEVL+ + DC + K D++A GL+ WEI R V +Y+ F V
Sbjct: 375 YMAPEVLDEQIR-TDCFESYKWTDIWAFGLVLWEIARR---TIVNGIVEDYRPPFYDVVP 430
Query: 442 NHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERM 501
N P+FEDM+ +V ++Q P P + + + L + + +CW + ARLTA ++ +
Sbjct: 431 NDPSFEDMKKVVCVDQQTPTIPNRLAADPV-LSGLAQMMRECWYPNPSARLTALRIKKTL 489
Query: 502 AELMMIWERNKSV 514
++ E+ K +
Sbjct: 490 QKISNSPEKPKVI 502
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 182 bits (463), Expect = 1e-45
Identities = 153/493 (31%), Positives = 225/493 (45%), Gaps = 72/493 (14%)
Query: 62 KGSTCYGLW-----EKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFC 116
KG TC G W + +G +GC + H E C P N
Sbjct: 42 KGPTCRGAWCTVVLVREEGRHPQEHRGCGN-------LHRELC--RGRPTEFVN----HY 88
Query: 117 CCSTDLCNVNFT---ENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFG-- 171
CC + LCN N + E PP P D + + L V L L+ G
Sbjct: 89 CCDSHLCNHNVSLVLEATQPPSEQP-------GTDGQLALILGPVLALLALVALGVLGLW 141
Query: 172 YRMLTGDRKQGLHSM---NMMEAAASEPS-------LDLD-------------------N 202
+ ++++GLHS + + ASE LD D
Sbjct: 142 HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQ 201
Query: 203 LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV 262
+ L+E +G+GRYG V++G VAVK+FS + Q++ E IY L+ HDNI FI
Sbjct: 202 VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 261
Query: 263 GDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG 322
D + + + L+ Y+ +GSL +L T + + RLA S GLA+LH E+ G
Sbjct: 262 SD-MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI-FG 319
Query: 323 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLS-MRLTGNRLVRPGEEDNAAISEVGTIR 381
KPAI+HRD SRNVLVK++ C I+D GL+ M G+ + G VGT R
Sbjct: 320 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN-----PRVGTKR 374
Query: 382 YMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVG 441
YMAPEVL+ + DC + K D++A GL+ WEI R V +Y+ F V
Sbjct: 375 YMAPEVLDEQIR-TDCFESYKWTDIWAFGLVLWEIARR---TIVNGIVEDYRPPFYDVVP 430
Query: 442 NHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERM 501
N P+FEDM+ +V ++Q P P + + + L + + +CW + ARLTA ++ +
Sbjct: 431 NDPSFEDMKKVVCVDQQTPTIPNRLAADPV-LSGLAQMMRECWYPNPSARLTALRIKKTL 489
Query: 502 AELMMIWERNKSV 514
++ E+ K +
Sbjct: 490 QKISNSPEKPKVI 502
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 179 bits (455), Expect = 9e-45
Identities = 131/393 (33%), Positives = 188/393 (47%), Gaps = 54/393 (13%)
Query: 117 CCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVL--AVLIVALCFGYRM 174
CC TD CN P P + E + I V +L ++IV L Y
Sbjct: 95 CCYTDYCN-RIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQ 153
Query: 175 LTGDRKQGLHSMNMMEAAASEPSLDLDN-----------------------------LKL 205
+Q L ME + E L D + L
Sbjct: 154 RVYHNRQRLD----MEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL 209
Query: 206 LELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE 265
E+IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 210 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 269
Query: 266 RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHY 325
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 270 KDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV-GTQG 327
Query: 326 KPAISHRDLNSRNVLVKNDGTCVISDFGLSMR---LTGNRLVRPGEEDNAAISEVGTIRY 382
KP I+HRDL S+N+LVK +G C I+D GL++R +T + P + VGT RY
Sbjct: 328 KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ-------RVGTKRY 380
Query: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGN 442
MAPEVL+ +N++ +S K D+YALGL+YWEI RC G EYQ+ + V +
Sbjct: 381 MAPEVLDETINMKHFDS-FKCADIYALGLVYWEIARRCNS---GGVHEEYQLPYYDLVPS 436
Query: 443 HPTFEDMQVLVSREKQRPKFPEAWKENSLAVRS 475
P+ E+M+ +V +K RP P W+ S VRS
Sbjct: 437 DPSIEEMRKVVCDQKLRPNIPNWWQ--SYEVRS 467
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 157 bits (397), Expect = 5e-38
Identities = 113/338 (33%), Positives = 161/338 (47%), Gaps = 49/338 (14%)
Query: 117 CCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVL--AVLIVALCFGYRM 174
CC TD CN P P + E + I V +L ++IV L Y
Sbjct: 95 CCYTDYCN-RIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQ 153
Query: 175 LTGDRKQGLHSMNMMEAAASEPSLDLDN-----------------------------LKL 205
+Q L ME + E L D + L
Sbjct: 154 RVYHNRQRLD----MEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVL 209
Query: 206 LELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDE 265
E+IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 210 QEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 269
Query: 266 RVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHY 325
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 270 KDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIV-GTQG 327
Query: 326 KPAISHRDLNSRNVLVKNDGTCVISDFGLSMR---LTGNRLVRPGEEDNAAISEVGTIRY 382
KP I+HRDL S+N+LVK +G C I+D GL++R +T + P + VGT RY
Sbjct: 328 KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQ-------RVGTKRY 380
Query: 383 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 420
MAPEVL+ +N++ +S K D+YALGL+YWEI RC
Sbjct: 381 MAPEVLDETINMKHFDS-FKCADIYALGLVYWEIARRC 417
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 146 bits (369), Expect = 9e-35
Identities = 88/230 (38%), Positives = 135/230 (58%), Gaps = 14/230 (6%)
Query: 277 LVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNS 336
LV EY+ GSL YL+ + +LA S+ GLA+LH E+ G KPAI+HRD+ S
Sbjct: 111 LVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIV-GTQGKPAIAHRDIKS 169
Query: 337 RNVLVKNDGTCVISDFGLSMRLTG--NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNL 394
+N+LVK TC I+D GL+++ N + P +VGT RYMAPE+L+ +N+
Sbjct: 170 KNILVKKCETCAIADLGLAVKHDSILNTIDIPQN------PKVGTKRYMAPEMLDDTMNV 223
Query: 395 RDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVS 454
ES K+ D+Y++GL+YWEI RC+ G V EYQ+ + V + P+ E+M+ +V
Sbjct: 224 NIFES-FKRADIYSVGLVYWEIARRCS---VGGIVEEYQLPYYDMVPSDPSIEEMRKVVC 279
Query: 455 REKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
+K RP P W ++ A+R + + +CW + ARLTA ++ +++L
Sbjct: 280 DQKFRPSIPNQW-QSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 328
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 90.9 bits (224), Expect = 6e-18
Identities = 111/462 (24%), Positives = 186/462 (40%), Gaps = 67/462 (14%)
Query: 186 MNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQNFINE 243
+ + + A P + ++ L+ EL+G+G +G V++ + VAVK+ +N
Sbjct: 4 VKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKI---------VNS 54
Query: 244 KNIYR----VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL-SLHTSDW 298
K I R + ++++ + R E+V D + LV ++ NGSL L S W
Sbjct: 55 KAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPW 114
Query: 299 VSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRL 358
CRL V G+ YLH + P + HRDL NVL+ + ++DFGLS
Sbjct: 115 PLLCRLLKEVVLGMFYLHDQ-------NPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ 167
Query: 359 TGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM 418
G++ E GT+ Y+APE+ VN+ A D+Y+ G++ W +
Sbjct: 168 GGSQSGTGSGEPG------GTLGYLAPELF---VNVN--RKASTASDVYSFGILMWAVLA 216
Query: 419 RCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKE 478
P E Y+ + N P+ ++ P+A E + LKE
Sbjct: 217 GREVELPTEPSLVYEAVCNRQ--NRPSLAEL-------------PQAGPETP-GLEGLKE 260
Query: 479 TIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVP 538
++ CW + + R + Q + E+ + E N ++ V+ + + R+ + +P
Sbjct: 261 LMQLCWSSEPKDRPSFQECLPKTDEVFQMVENN--MNAAVSTVKDFLSQLRSSNRRFSIP 318
Query: 539 KIGPYPDYSSS--SYIEDSIHHTDSIV----KNISSEHSMSSTPLTIGEKNRNSINYERQ 592
+ G IE+ D +V ++ E SS P + S E Q
Sbjct: 319 ESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQ 378
Query: 593 QAQA---------RIPSPETSVTSLSTNTTTTNTTGLTPSTG 625
QA P+T TS N + T+ TPS G
Sbjct: 379 VPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 420
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 86.3 bits (212), Expect = 1e-16
Identities = 86/309 (27%), Positives = 128/309 (41%), Gaps = 64/309 (20%)
Query: 188 MMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSL--DERPVAVKVFSFANRQNFINEKN 245
M AS + D+L+ E G G +G+VY+ ++ VAVK EK
Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-------EKE 53
Query: 246 IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL- 304
+ ++ H NI +F V + Y +V EY GSL Y++ + S+ + +
Sbjct: 54 AEILSVLSHRNIIQFY----GVILEPP-NYGIVTEYASLGSLYDYINSNRSEEMDMDHIM 108
Query: 305 --AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNR 362
A V +G+ YLH E P + HRDL SRNV++ DG I DFG S
Sbjct: 109 TWATDVAKGMHYLHMEAP------VKVIHRDLKSRNVVIAADGVLKICDFGASR------ 156
Query: 363 LVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTD 422
+S VGT +MAPEV++ C D Y+ G++ WE+ R
Sbjct: 157 ----FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC-------DTYSYGVVLWEMLTR--- 202
Query: 423 LFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIED 482
P + + Q+A+ LV + +R P S RS E +
Sbjct: 203 EVPFKGLEGLQVAW---------------LVVEKNERLTIP------SSCPRSFAELLHQ 241
Query: 483 CWDQDAEAR 491
CW+ DA+ R
Sbjct: 242 CWEADAKKR 250
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 86.3 bits (212), Expect = 1e-16
Identities = 86/309 (27%), Positives = 128/309 (41%), Gaps = 64/309 (20%)
Query: 188 MMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSL--DERPVAVKVFSFANRQNFINEKN 245
M AS + D+L+ E G G +G+VY+ ++ VAVK EK
Sbjct: 1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKI-------EKE 53
Query: 246 IYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL- 304
+ ++ H NI +F V + Y +V EY GSL Y++ + S+ + +
Sbjct: 54 AEILSVLSHRNIIQFY----GVILEPP-NYGIVTEYASLGSLYDYINSNRSEEMDMDHIM 108
Query: 305 --AHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNR 362
A V +G+ YLH E P + HRDL SRNV++ DG I DFG S
Sbjct: 109 TWATDVAKGMHYLHMEAP------VKVIHRDLKSRNVVIAADGVLKICDFGASR------ 156
Query: 363 LVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTD 422
+S VGT +MAPEV++ C D Y+ G++ WE+ R
Sbjct: 157 ----FHNHTTHMSLVGTFPWMAPEVIQSLPVSETC-------DTYSYGVVLWEMLTR--- 202
Query: 423 LFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIED 482
P + + Q+A+ LV + +R P S RS E +
Sbjct: 203 EVPFKGLEGLQVAW---------------LVVEKNERLTIP------SSCPRSFAELLHQ 241
Query: 483 CWDQDAEAR 491
CW+ DA+ R
Sbjct: 242 CWEADAKKR 250
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 82.8 bits (203), Expect = 2e-15
Identities = 67/227 (29%), Positives = 105/227 (46%), Gaps = 34/227 (14%)
Query: 198 LDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVF------SFANRQNFINEKNIYRVPL 251
L L ++ E+IG G +G VYKG + VA+K + S ++ F E +I +
Sbjct: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSI--LCQ 515
Query: 252 MEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL--SLHTSDWVSSCRLAHSVT 309
+ H + +F+ + ++ +V +Y GSL L D S +A V
Sbjct: 516 LNHPCVIQFV----GACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVA 571
Query: 310 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 369
+G+ YLH + I HRDLNS N+L+ DG V++DFG S R ++ +E
Sbjct: 572 KGMEYLH-------NLTQPIIHRDLNSHNILLYEDGHAVVADFGES------RFLQSLDE 618
Query: 370 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI 416
DN + G +R+MAPEV C + D+++ L WEI
Sbjct: 619 DNMT-KQPGNLRWMAPEV------FTQCTRYTIKADVFSYALCLWEI 658
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 82.8 bits (203), Expect = 2e-15
Identities = 67/227 (29%), Positives = 105/227 (46%), Gaps = 34/227 (14%)
Query: 198 LDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVF------SFANRQNFINEKNIYRVPL 251
L L ++ E+IG G +G VYKG + VA+K + S ++ F E +I +
Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSI--LCQ 616
Query: 252 MEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL--SLHTSDWVSSCRLAHSVT 309
+ H + +F+ + ++ +V +Y GSL L D S +A V
Sbjct: 617 LNHPCVIQFV----GACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVA 672
Query: 310 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 369
+G+ YLH + I HRDLNS N+L+ DG V++DFG S R ++ +E
Sbjct: 673 KGMEYLH-------NLTQPIIHRDLNSHNILLYEDGHAVVADFGES------RFLQSLDE 719
Query: 370 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI 416
DN + G +R+MAPEV C + D+++ L WEI
Sbjct: 720 DNMT-KQPGNLRWMAPEV------FTQCTRYTIKADVFSYALCLWEI 759
>gi|4885489 v-mos Moloney murine sarcoma viral oncogene homolog
[Homo sapiens]
Length = 346
Score = 80.5 bits (197), Expect = 8e-15
Identities = 79/322 (24%), Positives = 132/322 (40%), Gaps = 66/322 (20%)
Query: 197 SLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFS------FANRQNFINEKNIYRVP 250
S+D + + LL+ +G G +G+VYK + PVA+K + A+R++F E N+ R
Sbjct: 54 SIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVAR-- 111
Query: 251 LMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL--------------SLHTS 296
+ HDNI R + R A ++ME+ N +L + + T
Sbjct: 112 -LRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTG 170
Query: 297 DWVS---SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFG 353
+S + + V GL +LH++ +I H DL N+L+ C ISDFG
Sbjct: 171 GQLSLGKCLKYSLDVVNGLLFLHSQ---------SIVHLDLKPANILISEQDVCKISDFG 221
Query: 354 LSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIY 413
S +L + + GT + APE+L+G E + D+Y+ +
Sbjct: 222 CSEKLEDLLCFQ-----TPSYPLGGTYTHRAPELLKG-------EGVTPKADIYSFAITL 269
Query: 414 WEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAV 473
W++ + + GE + + V RP A E+SL
Sbjct: 270 WQMTTKQAP-YSGER------------------QHILYAVVAYDLRPSLSAAVFEDSLPG 310
Query: 474 RSLKETIEDCWDQDAEARLTAQ 495
+ L + I+ CW A R +A+
Sbjct: 311 QRLGDVIQRCWRPSAAQRPSAR 332
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 80.1 bits (196), Expect = 1e-14
Identities = 83/308 (26%), Positives = 139/308 (45%), Gaps = 67/308 (21%)
Query: 198 LDLDNLKLLELIGRGRYGAVYKGSLD-----ERPVAVKV----FSFANRQNFINEKNIYR 248
+D+ +K+ E+IG G +G V +G L E VA+K ++ R+ F++E +I
Sbjct: 610 IDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASI-- 667
Query: 249 VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDW--VSSCRLAH 306
+ EH NI R E V + M +++ E+ NG+L +L L+ + + +
Sbjct: 668 MGQFEHPNIIRL----EGVVTNS-MPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLR 722
Query: 307 SVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRP 366
+ G+ YL + + HRDL +RN+LV ++ C +SDFGLS R +
Sbjct: 723 GIASGMRYLA---------EMSYVHRDLAARNILVNSNLVCKVSDFGLS------RFLEE 767
Query: 367 GEEDNAAISEVG---TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDL 423
D S +G IR+ APE A+ R SA D ++ G++ WE+ +
Sbjct: 768 NSSDPTYTSSLGGKIPIRWTAPE----AIAFRKFTSA---SDAWSYGIVMWEV------M 814
Query: 424 FPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDC 483
GE P + M+ Q D+ + ++ + P P+ SL + + DC
Sbjct: 815 SFGER-PYWDMSNQ----------DVINAIEQDYRLPPPPD-------CPTSLHQLMLDC 856
Query: 484 WDQDAEAR 491
W +D AR
Sbjct: 857 WQKDRNAR 864
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 75.9 bits (185), Expect = 2e-13
Identities = 67/238 (28%), Positives = 105/238 (44%), Gaps = 59/238 (24%)
Query: 198 LDLDNLKLLELIGRGRYGAVYKGSLDERPVAVK-VFSFANRQNFINEKNIYRVPLMEHDN 256
+D +++ E++GRG +G V K + VA+K + S + R+ FI E + ++ + H N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVE--LRQLSRVNHPN 88
Query: 257 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCK----------YLSLHTSDWVSSCRLAH 306
I + LVMEY GSL Y + H W C
Sbjct: 89 IVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQC---- 137
Query: 307 SVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFG----LSMRLTGN 361
++G+AYLH+ P+ A+ HRDL N+L+ GT + I DFG + +T N
Sbjct: 138 --SQGVAYLHSMQPK------ALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN 189
Query: 362 RLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMR 419
+ G+ +MAPEV EG+ C D+++ G+I WE+ R
Sbjct: 190 K---------------GSAAWMAPEVFEGSNYSEKC-------DVFSWGIILWEVITR 225
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 75.9 bits (185), Expect = 2e-13
Identities = 67/238 (28%), Positives = 105/238 (44%), Gaps = 59/238 (24%)
Query: 198 LDLDNLKLLELIGRGRYGAVYKGSLDERPVAVK-VFSFANRQNFINEKNIYRVPLMEHDN 256
+D +++ E++GRG +G V K + VA+K + S + R+ FI E + ++ + H N
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVE--LRQLSRVNHPN 88
Query: 257 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCK----------YLSLHTSDWVSSCRLAH 306
I + LVMEY GSL Y + H W C
Sbjct: 89 IVKLYGACLNPVC-------LVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQC---- 137
Query: 307 SVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCV-ISDFG----LSMRLTGN 361
++G+AYLH+ P+ A+ HRDL N+L+ GT + I DFG + +T N
Sbjct: 138 --SQGVAYLHSMQPK------ALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN 189
Query: 362 RLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMR 419
+ G+ +MAPEV EG+ C D+++ G+I WE+ R
Sbjct: 190 K---------------GSAAWMAPEVFEGSNYSEKC-------DVFSWGIILWEVITR 225
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,559,863
Number of Sequences: 37866
Number of extensions: 1996847
Number of successful extensions: 8644
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 260
Number of HSP's successfully gapped in prelim test: 483
Number of HSP's that attempted gapping in prelim test: 5838
Number of HSP's gapped (non-prelim): 2124
length of query: 1038
length of database: 18,247,518
effective HSP length: 112
effective length of query: 926
effective length of database: 14,006,526
effective search space: 12970043076
effective search space used: 12970043076
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.