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Search of human proteins with 153792351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
(889 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 1871 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 885 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 800 0.0
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 685 0.0
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 652 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 632 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 603 e-172
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 452 e-127
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 430 e-120
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 412 e-115
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 405 e-113
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 402 e-111
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 379 e-105
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 374 e-103
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 372 e-103
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 364 e-100
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 362 1e-99
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 345 1e-94
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 343 5e-94
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 288 2e-77
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 288 2e-77
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 268 2e-71
gi|145309328 papilin [Homo sapiens] 188 2e-47
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 184 4e-46
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 177 4e-44
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 177 4e-44
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 177 4e-44
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 162 1e-39
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 162 1e-39
gi|226442878 ADAMTS-like 5 [Homo sapiens] 152 2e-36
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 1871 bits (4846), Expect = 0.0
Identities = 889/889 (100%), Positives = 889/889 (100%)
Query: 1 MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF 60
MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF
Sbjct: 1 MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF 60
Query: 61 GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR 120
GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR
Sbjct: 61 GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR 120
Query: 121 GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG 180
GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG
Sbjct: 121 GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG 180
Query: 181 DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ 240
DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ
Sbjct: 181 DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ 240
Query: 241 NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF 300
NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF
Sbjct: 241 NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF 300
Query: 301 NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT 360
NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT
Sbjct: 301 NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT 360
Query: 361 LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG 420
LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG
Sbjct: 361 LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG 420
Query: 421 HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD 480
HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD
Sbjct: 421 HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD 480
Query: 481 GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR 540
GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR
Sbjct: 481 GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR 540
Query: 541 TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY 600
TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY
Sbjct: 541 TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY 600
Query: 601 TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ 660
TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ
Sbjct: 601 TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ 660
Query: 661 CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ 720
CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ
Sbjct: 661 CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ 720
Query: 721 RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR 780
RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR
Sbjct: 721 RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR 780
Query: 781 PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD 840
PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD
Sbjct: 781 PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD 840
Query: 841 WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL 889
WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL
Sbjct: 841 WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL 889
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 885 bits (2287), Expect = 0.0
Identities = 452/913 (49%), Positives = 597/913 (65%), Gaps = 54/913 (5%)
Query: 4 APAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPT--RLPGSAGELALHLSAFG 61
AP + + P+ LLLL L + A + ELVVP R PG G L L AF
Sbjct: 24 APGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELVVPELERAPGH-GTTRLRLHAFD 82
Query: 62 KGFVLRLAPDDSFLAPEFKIERLGG-SGRATG-GERGLRGCFFSGTVNGEPESLAAVSLC 119
+ L L PD SFLAP F ++ +G SG T E L CF+SGTVNG+P S AA+SLC
Sbjct: 83 QQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSLC 142
Query: 120 RGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLP-------RGPEWEVETG 172
G+ G+F L GE + IQP A RL P P P R + +V
Sbjct: 143 EGVRGAFYLLGEAYFIQPLPAASE-----RLATAAPGEKPPAPLQFHLLRRNRQGDVGGT 197
Query: 173 EG----QRQERGDHQEDSEEESQEEEAEGASEPPP---------PLGATS-RTKRFVSEA 218
G + + G + + E+E E E EGA P P G S R KRFVS
Sbjct: 198 CGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSIRKKRFVSSH 257
Query: 219 RFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKW 278
R+VET+LVAD SMA F+G+ L++++LTL SVAAR+YKHPSI+NS++L+VVK+L++ DE+
Sbjct: 258 RYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQK 317
Query: 279 GPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIG 338
GPEV+ N LTLRNFCNWQ++ N PSDR EHYDTAIL TRQ+ CG + CDTLG+AD+G
Sbjct: 318 GPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQ-TCDTLGMADVG 376
Query: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVH 398
T+CDP++SCSVIED+GLQAA T AHELGHV +MPHDD+K C L G H+MA + +
Sbjct: 377 TVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLSN 436
Query: 399 LNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGP 458
L+ + PWSPCSA +T LD GHG+CL+D P + LP LPG Y ++QC+ FG
Sbjct: 437 LDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTS--YDANRQCQFTFGE 494
Query: 459 DFRHCPNTSAQDVCAQLWCH-TDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEE 517
D +HCP+ A C+ LWC T G +C TK+ PWADGT CG G C G C+ + +
Sbjct: 495 DSKHCPD--AASTCSTLWCTGTSGGVLVCQTKH--FPWADGTSCGEGKWCINGKCVNKTD 550
Query: 518 VERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHT 577
+ G W WGPWG+CSRTCGGGVQ++ REC +P P+NGG+YC G+R +Y+SC+
Sbjct: 551 RKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNL 610
Query: 578 EECPPD-GKSFREQQCEKYNAYNYTDM-DGNLLQWVPKYAGVSPRDRCKLFCRARGRSEF 635
E+CP + GK+FRE+QCE +N ++ G ++W+PKYAGVSP+DRCKL C+A+G F
Sbjct: 611 EDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYF 670
Query: 636 KVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGS 695
V + KV+DGT C P++ ++CV+GQCVKAGCD ++DS +K DKCGVCGG G++C+K+SGS
Sbjct: 671 FVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS 730
Query: 696 LTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQ 755
+T GY+DI+TIP GATNI+VKQR+ G +N+G++LA+K ADG Y+LNG+ +S +EQ
Sbjct: 731 VTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQ 790
Query: 756 DILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFS 815
DI+ KG +L+YSGS A LER++SF PL EPLT+Q+LTV G PK+KYT+FV
Sbjct: 791 DIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTV-GNALRPKIKYTYFV------- 842
Query: 816 MQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALK 875
K++ + N I + WV+ +W ECS +C GWQRR VECRD +GQ ++ C K +K
Sbjct: 843 ---KKKKESFNAIPTF--SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVK 897
Query: 876 PEDAKPCESQLCP 888
P +PC CP
Sbjct: 898 PASTRPCADHPCP 910
Score = 32.3 bits (72), Expect = 2.0
Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 2/44 (4%)
Query: 512 CLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHREC 553
C E + +P AD W G W CS+TCG G + +C
Sbjct: 892 CAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKC 935
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 800 bits (2065), Expect = 0.0
Identities = 423/917 (46%), Positives = 575/917 (62%), Gaps = 65/917 (7%)
Query: 15 LLLLLLLPLARGAPARPAAGGQAS-ELVVPTRL-------------PGSAGE--LALHLS 58
+LLL +L LA R A G + E+VVP RL P +G+ L ++
Sbjct: 1 MLLLGILTLAFAG--RTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQIT 58
Query: 59 AFGKGFVLRLAPDDSFLAPEFKIERLGGSGRA-TGGERGLRGCFFSGTVNGEPESLAAVS 117
AF + F L L PD FLAP F E LG + TGG LR CF+SG VN EP+S AAVS
Sbjct: 59 AFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVS 118
Query: 118 LCRGLSGSFLLDGEEFTIQP-QGAGGSLAQ-----PHRLQRWGPAGARPLPRGPEWEVET 171
LC GL G+F G E+ I P A AQ H LQR G G V +
Sbjct: 119 LCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVAS 178
Query: 172 GEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASM 231
G R D + + E S + R KRFVS R+VETL+VAD SM
Sbjct: 179 GWNPAILRA---LDPYKPRRAGFGESRSRR-----RSGRAKRFVSIPRYVETLVVADESM 230
Query: 232 AAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLR 291
F+GADL++++LTL++ AAR+Y+HPSI N IN++VVKVL++ D GP+V+ N LTLR
Sbjct: 231 VKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLR 290
Query: 292 NFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIE 351
NFC WQ++ N+ SD+HPE++DTAIL TRQ+ CG CDTLG+AD+GT+CDP +SCSVIE
Sbjct: 291 NFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGAT-TCDTLGMADVGTMCDPKRSCSVIE 349
Query: 352 DEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAM 411
D+GL +A T AHELGHV +MPHD+ K C +FG + +H+M+P + +++ PWS CSA
Sbjct: 350 DDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAA 409
Query: 412 YLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDV 471
+T+ LD GHGDCLLD P+ + LP LPG A Y L QQC FG + CP
Sbjct: 410 IITDFLDSGHGDCLLDQPSKPISLPEDLPG--ASYTLSQQCELAFGVGSKPCPY---MQY 464
Query: 472 CAQLWCHTDG-AEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWA 530
C +LWC + +C T++ PWADGT CG G LC +G+C+ + + + DG WA
Sbjct: 465 CTKLWCTGKAKGQMVCQTRH--FPWADGTSCGEGKLCLKGACVERHNLNKHR--VDGSWA 520
Query: 531 PWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD--GKSFR 588
W P+G CSRTCGGGVQ + R+C +P P NGG+YC G R KY+SC+ E CP GKSFR
Sbjct: 521 KWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFR 580
Query: 589 EQQCEKYNAYNYTDMDGNL-LQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTL 647
E+QCE +N YN++ L + WVPKY+GVSPRD+CKL CRA G F V KV+DGTL
Sbjct: 581 EEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTL 640
Query: 648 CGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIV 707
C P++ ++CV+G+C+KAGCD + S ++ DKCGVCGG SC+KV+G T +GYN +V
Sbjct: 641 CSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVV 700
Query: 708 TIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYS 767
IPAGA++ID++QR + G+ D NYLALK + G+YLLNG+ +SA+E+D++VKG++L+YS
Sbjct: 701 AIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYS 760
Query: 768 GSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND--VDFSMQSSKERATT 825
G+ +E LQ+ RP+ EPLTV++L+V G++ PP+V+Y+F++P + D S R +
Sbjct: 761 GTGTAVESLQASRPILEPLTVEVLSV-GKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPS 819
Query: 826 NIIQPLLH-------------AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASA-TCN 871
+ +L A+WV G W CS++CG+G Q+R V+CR +GQ + C+
Sbjct: 820 VLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACD 879
Query: 872 KALKPEDAKPCESQLCP 888
A +P + + C + CP
Sbjct: 880 AAHRPVETQAC-GEPCP 895
Score = 45.4 bits (106), Expect = 2e-04
Identities = 21/54 (38%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLC 887
W L WS CS +CG G+QRR+++C G+ A CN KP++ C + C
Sbjct: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 685 bits (1767), Expect = 0.0
Identities = 369/819 (45%), Positives = 498/819 (60%), Gaps = 75/819 (9%)
Query: 13 LLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSA-------GELALHLSAFGKGFV 65
LLLLL LLP AR A P + E+V P +L GS L L AFG+ +
Sbjct: 38 LLLLLASLLPSARLASPLP----REEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLL 93
Query: 66 LRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCRG-LSG 124
L L D ++ LG + GG G + +GT+NG+PES+A++ G L G
Sbjct: 94 LELEQDSGVQVEGLTVQYLGQAPELLGGAEP--GTYLTGTINGDPESVASLHWDGGALLG 151
Query: 125 SFLLDGEEFTIQ------PQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQE 178
G E +Q P AGG A H L+R PA +GP V+ G
Sbjct: 152 VLQYRGAELHLQPLEGGTPNSAGGPGA--HILRRKSPASG----QGPMCNVKAPLG---- 201
Query: 179 RGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGAD 238
S P P R KRF S +RFVETL+VAD MAAF+GA
Sbjct: 202 --------------------SPSPRP----RRAKRFASLSRFVETLVVADDKMAAFHGAG 237
Query: 239 LQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQR 298
L+ ++LT+M+ AA+ +KHPSI+N ++L+V +++I+ + GP+V + TLR+FC WQR
Sbjct: 238 LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQR 297
Query: 299 RFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAA 358
N P D P+H+DTAIL TRQ+ CG CDTLG+AD+GT+CDP +SC+++ED+GLQ+A
Sbjct: 298 GLNTPEDSDPDHFDTAILFTRQDLCG-VSTCDTLGMADVGTVCDPARSCAIVEDDGLQSA 356
Query: 359 HTLAHELGHVLSMPHDDSKPCTRLFGPMG-KHHVMAPLFVHLNQTLPWSPCSAMYLTELL 417
T AHELGHV +M HD+SKPC L GP+ HVMAP+ H++ PWSPCSA ++T+ L
Sbjct: 357 FTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFL 416
Query: 418 DGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWC 477
D G+G CLLD P A L LP PG+ Y D+QC+ FGPD RHCP CA LWC
Sbjct: 417 DNGYGHCLLDKPEAPLHLPVTFPGKD--YDADRQCQLTFGPDSRHCPQLPPP--CAALWC 472
Query: 478 --HTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPW 535
H +G +C TK+ PWADGTPCGP C G CL ++++ GGW PWGPW
Sbjct: 473 SGHLNG-HAMCQTKHS--PWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPW 529
Query: 536 GECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPP-DGKSFREQQCEK 594
G+CSRTCGGGVQFS R+C P P+NGG+YC GRR +++SC+TE+CP +FRE+QC
Sbjct: 530 GDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAA 589
Query: 595 YNAYNYTDMDGNL---LQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE 651
YN + TD+ + + WVP+Y GV+P+D+CKL C+A+ + V E +V+DGT C P+
Sbjct: 590 YN--HRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPD 647
Query: 652 TLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPA 711
+ ++CV+G+C+ AGCD ++ S +K DKC VCGG G+ C K SGS YGYN++VTIPA
Sbjct: 648 SSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPA 707
Query: 712 GATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTI-LKYSGSI 770
GAT+I V+Q+ +PG + YLALK DG Y LNG + D+++ G + L+YSG+
Sbjct: 708 GATHILVRQQGNPG--HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGAT 765
Query: 771 ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
A E L PL +PLT+Q+L V G +++Y+FFVP
Sbjct: 766 AASETLSGHGPLAQPLTLQVL-VAGNPQDTRLRYSFFVP 803
Score = 30.4 bits (67), Expect = 7.6
Identities = 11/24 (45%), Positives = 14/24 (58%)
Query: 839 GDWSECSSTCGAGWQRRTVECRDP 862
G W +CS TCG G Q + +C P
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRP 550
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 652 bits (1682), Expect = 0.0
Identities = 359/873 (41%), Positives = 482/873 (55%), Gaps = 51/873 (5%)
Query: 45 RLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSG 104
+L G++ + A G+ F+L L D S F + G + R CF+ G
Sbjct: 79 QLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGF----VPAGGGTSAPWRHRSHCFYRG 134
Query: 105 TVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRG 164
TV+G P SLA LC GL G F + +T++P G A+ + + +G AR L
Sbjct: 135 TVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPL-LRGPWAEEEKGRVYGDGSARIL--- 190
Query: 165 PEWEVETGEGQRQE----RGDHQEDSEEESQEEEAEGASEPP---------------PPL 205
V T EG E R + + E A S P P
Sbjct: 191 ---HVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPA 247
Query: 206 GATS------RTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSI 259
G + R +R +S AR VE LLVADASMA YG LQ+++LTL S+A R+Y H SI
Sbjct: 248 GGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASI 307
Query: 260 KNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTR 319
+N I L VVKV+++ D+ EVS N TL+NFC WQ + NQ D H EHYD AIL TR
Sbjct: 308 ENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTR 367
Query: 320 QNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPC 379
++ CG CDTLG+AD+GTIC P +SC+VIED+GL AA T+AHE+GH+L + HDDSK C
Sbjct: 368 EDLCGHHS-CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFC 426
Query: 380 TRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTGL 439
FG +M+ + ++ + PWS C++ +TE LD GHG+CLLD P + P L
Sbjct: 427 EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEEL 486
Query: 440 PGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHT-DGAEPLCHTKNGSLPWADG 498
PG+ Y QQC FGP++ CP DVCA+LWC + +C TK LP +G
Sbjct: 487 PGQT--YDATQQCNLTFGPEYSVCPG---MDVCARLWCAVVRQGQMVCLTKK--LPAVEG 539
Query: 499 TPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
TPCG G +C +G C+ + + + + G W WG WG+CSR+CGGGVQF++R C +P P
Sbjct: 540 TPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAP 599
Query: 559 QNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPKYAG 616
+N GRYC G+RA Y+SC CPP+GKSFR +QCE N Y +D G ++WVPKYAG
Sbjct: 600 RNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQ-SDAKGVKTFVEWVPKYAG 658
Query: 617 VSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKL 676
V P D CKL CRA+G + VF KV DGT C + ++CVRG+CV+ GCD ++ S +
Sbjct: 659 VLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQY 718
Query: 677 DKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALK 736
DKCGVCGG +SC K+ G+ + GY D+V IP GAT+I V+Q YLALK
Sbjct: 719 DKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALK 778
Query: 737 TADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERL--QSFRPLPEPLTVQLLTVP 794
+G+YL+NG IS E I + GT++ YSG + L + E L VQ+L
Sbjct: 779 KKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILAT- 837
Query: 795 GEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
P V+Y+FFVP + S + + QWV G W CS TC GW
Sbjct: 838 DPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHT 897
Query: 855 RTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
RTV+C+D + + + C + +P K C + C
Sbjct: 898 RTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
9 preproprotein [Homo sapiens]
Length = 1935
Score = 632 bits (1629), Expect = 0.0
Identities = 348/872 (39%), Positives = 501/872 (57%), Gaps = 88/872 (10%)
Query: 57 LSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRA-----TGGERGLRGCFFSGTVNGEPE 111
LSAFG+ F+ L + F+AP F + LG G + E L+ CF+ G VN E
Sbjct: 102 LSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSE 161
Query: 112 SLAAVSLCRGLSGSFLLDGEEFTIQP------QGAGGSLAQPHRLQRWGPAGARPLPRGP 165
A +SLC G+ G+F ++ I+P Q +PH + R P
Sbjct: 162 HTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRS---------AP 212
Query: 166 EWEVETGE---GQRQERGDHQEDSEEESQEEEAEG--------------ASEPPPPLGAT 208
+ E TG + + H +D ++ + E A+E G
Sbjct: 213 QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNK 272
Query: 209 S----------RTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
+ RTKRF+S RFVE L+VAD M +++G +LQ++ILTLMS+ A IYK PS
Sbjct: 273 TDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPS 332
Query: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
I N IN+++V ++++ +E+ GP +S N TL+NFC WQ N P H +DTA+LLT
Sbjct: 333 IGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLT 389
Query: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
RQ+ C CDTLG+A++GTICDP +SCS+ ED GL A T+AHELGHV +MPHDD+
Sbjct: 390 RQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNK 449
Query: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPT 437
C G HVMAP WS CS Y+TE LD G+G+CLL+ P + PLP
Sbjct: 450 CKEE-GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPV 508
Query: 438 GLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHT-DGAEPLCHTKNGSLPWA 496
LPG LY +++QC IFGP + CP C +LWC+ +G C T++ PWA
Sbjct: 509 QLPG--ILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQH--TPWA 561
Query: 497 DGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDP 556
DGT C PG C G C+P+E PV DG W W P+G CSRTCGGG++ + REC P
Sbjct: 562 DGTECEPGKHCKYGFCVPKE---MDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
Query: 557 EPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNL--LQWVPKY 614
EP+NGG+YC+GRR K++SC+TE C + FR++QC ++ ++ +++G L ++WVPKY
Sbjct: 619 EPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHF-NINGLLPNVRWVPKY 677
Query: 615 AGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPR 674
+G+ +DRCKLFCR G + + +VIDGT CG +T ICV+G C +AGCDHV++S
Sbjct: 678 SGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKA 737
Query: 675 KLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLA 734
+ DKCGVCGG +SC+ V+G+ +YGYN +V IPAGATNIDV+Q S G +D NYLA
Sbjct: 738 RRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLA 797
Query: 735 LKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVP 794
L ++ G++LLNGN ++ +++I + +++YSGS +ER+ S + + L +Q+L+V
Sbjct: 798 LSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV- 856
Query: 795 GEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
G+++ P V+Y+F +P ++ ++ N G W CS C G ++
Sbjct: 857 GKLYNPDVRYSFNIP------IEDKPQQFYWN----------SHGPWQACSKPC-QGERK 899
Query: 855 RTVECRDPSGQASAT---CNKALKP-EDAKPC 882
R + C S Q + + C++ +P +PC
Sbjct: 900 RKLVCTRESDQLTVSDQRCDRLPQPGHITEPC 931
Score = 62.4 bits (150), Expect = 2e-09
Identities = 25/54 (46%), Positives = 33/54 (61%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
QW G W CSSTC G QRR V C+D +G + C + +KP++ + CES CP
Sbjct: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 52.4 bits (124), Expect = 2e-06
Identities = 21/51 (41%), Positives = 30/51 (58%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCES 884
A W +G+W CS +CG G +R+V+C Q S C+ LKPE+ K C +
Sbjct: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRN 1729
Score = 48.9 bits (115), Expect = 2e-05
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
QW G+W EC+ CG G + R V C+ +G+ +C KP D + C + CP
Sbjct: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
Score = 48.5 bits (114), Expect = 3e-05
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS--ATCNKALKPEDAKPCESQLCPL 889
+W G WS+CS +CG G Q+R V C+ + + + CN +PE + C+ CPL
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPL 1556
Score = 48.1 bits (113), Expect = 4e-05
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKALKPEDAKPCESQLC 887
A W G W +CS TCG G+Q R V+C S CN A +P D + CE C
Sbjct: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Score = 46.6 bits (109), Expect = 1e-04
Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 2/80 (2%)
Query: 810 NDV-DFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS- 867
NDV D S + +E+ T QW GDWSEC TCG G + R V C+ + +
Sbjct: 1029 NDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLND 1088
Query: 868 ATCNKALKPEDAKPCESQLC 887
C+ KP + C+ C
Sbjct: 1089 RMCDPETKPTSMQTCQQPEC 1108
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 10/63 (15%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECR---------DPSGQASATCNKALKPEDAKPCESQL 886
W+ G+WSECS TCG G+++R V C + S Q + C +P PC +
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINC-PGTQPPSVHPCYLRD 1674
Query: 887 CPL 889
CP+
Sbjct: 1675 CPV 1677
Score = 46.2 bits (108), Expect = 1e-04
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVEC--RDPSGQASATCNKALKPEDAKPCESQLCP 888
A W G WS CS +CG G ++R V C +D S S C KP + C CP
Sbjct: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCP 1499
Score = 45.8 bits (107), Expect = 2e-04
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS--ATCNKALKPEDAKPCESQLC 887
QW G W+ CS+TCG G + R V CRD +G + + C +P + C C
Sbjct: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPC 1239
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLC 887
W +W EC+ TCG G + R V C D + A C+ + +P D + C Q C
Sbjct: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCP 888
QW DWS CS TCG G R V C + S + C++ PE + C CP
Sbjct: 1241 QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCP 1296
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 16/79 (20%)
Query: 518 VERPKP----VADGGWAP---WGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY------ 564
VER KP + G P +G WGEC++ CGGG++ C + NG R+
Sbjct: 1367 VERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCE 1423
Query: 565 CLGRRAKYQSCHTEECPPD 583
L + + C+T CP D
Sbjct: 1424 ILDKPPDREQCNTHACPHD 1442
Score = 40.8 bits (94), Expect = 0.006
Identities = 65/240 (27%), Positives = 89/240 (37%), Gaps = 45/240 (18%)
Query: 494 PWAD-GTPCGPGH-------LCSEGSCLPEEEVER-PKPVAD----GGWAP-W--GPWGE 537
PW+ CG GH + +GS L + + KP GG P W G W +
Sbjct: 1449 PWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQ 1508
Query: 538 CSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNA 597
CS +CG GVQ H C+ G + + R EC P + E+ C+
Sbjct: 1509 CSVSCGRGVQQRHVGCQI------GTHKIARET--------ECNPYTRPESERDCQGPRC 1554
Query: 598 YNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICV 657
YT Q K G R R K+ C ++E + G C +
Sbjct: 1555 PLYT-WRAEEWQECTKTCGEGSRYR-KVVCVDDNKNE--------VHGARCDVSKRPV-D 1603
Query: 658 RGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT---NYGYNDIVTIPAGAT 714
R C C++V + + +C V GKG R VS S T NY Y+ TI T
Sbjct: 1604 RESCSLQPCEYVWIT-GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGT 1662
Score = 36.2 bits (82), Expect = 0.14
Identities = 23/67 (34%), Positives = 27/67 (40%), Gaps = 14/67 (20%)
Query: 501 CGPGHL-----CSEGS-------CLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGV 546
CG GH C G C PE + + A W GPWG+CS TCG G
Sbjct: 1068 CGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGY 1127
Query: 547 QFSHREC 553
Q +C
Sbjct: 1128 QLRAVKC 1134
Score = 35.4 bits (80), Expect = 0.24
Identities = 27/98 (27%), Positives = 39/98 (39%), Gaps = 21/98 (21%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNG--GRYCLGR--RAKYQSCHTEECPP------ 582
GPWG CS TC GG Q C+D +NG C+ R + ++C + CP
Sbjct: 1335 GPWGACSSTCAGGSQRRVVVCQD---ENGYTANDCVERIKPDEQRACESGPCPQWAYGNW 1391
Query: 583 --------DGKSFREQQCEKYNAYNYTDMDGNLLQWVP 612
G R C++ N + D+ +L P
Sbjct: 1392 GECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPP 1429
Score = 32.0 bits (71), Expect = 2.6
Identities = 24/85 (28%), Positives = 31/85 (36%), Gaps = 20/85 (23%)
Query: 530 APW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSF 587
A W G WG CS +CG GV +C E Q CHT+ P + K+
Sbjct: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS-----------HLCHTDLKPEERKTC 1727
Query: 588 RE-------QQCEKYNAYNYTDMDG 605
R Q C++ DG
Sbjct: 1728 RNVYNCELPQNCKEVKRLKGASEDG 1752
Score = 30.8 bits (68), Expect = 5.8
Identities = 11/24 (45%), Positives = 13/24 (54%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVEC 859
W W+ECS +C G QRR C
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAIC 1024
Score = 30.4 bits (67), Expect = 7.6
Identities = 12/27 (44%), Positives = 15/27 (55%), Gaps = 1/27 (3%)
Query: 527 GGWAPWGPWGECSRTCGGGVQFSHREC 553
GGW + W ECS++C GG Q C
Sbjct: 999 GGWR-YSAWTECSKSCDGGTQRRRAIC 1024
Score = 30.0 bits (66), Expect = 10.0
Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 2/50 (4%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC--LGRRAKYQSCHTEEC 580
G W EC TCG G + C+ E + R C + Q+C EC
Sbjct: 1059 GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 30.0 bits (66), Expect = 10.0
Identities = 10/24 (41%), Positives = 14/24 (58%)
Query: 532 WGPWGECSRTCGGGVQFSHRECKD 555
+G W CS TCG G + + C+D
Sbjct: 1188 FGSWTPCSATCGKGTRMRYVSCRD 1211
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 603 bits (1556), Expect = e-172
Identities = 330/823 (40%), Positives = 488/823 (59%), Gaps = 53/823 (6%)
Query: 58 SAFGKGFVLRLAPDDSFLAPEFKIERLG----GSGRATGGERGLRGCFFSGTVNGEPESL 113
+A+G+ F L L D SFLA + LG G+ + G LR CF+ G VN + +
Sbjct: 83 TAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYK 142
Query: 114 AAVSLCRGLSGSFLLDGEEFTIQP-QGAGGSLAQ-----PHRLQRWGPAGA--RPLPRGP 165
A VSLC GL+G+F E+ ++P A G+ + PH + R + + L
Sbjct: 143 AVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCS 202
Query: 166 EWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGAT---SRTKRFVSEARFVE 222
E + E + + +E G + PL SR KR +S R++E
Sbjct: 203 VSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIE 262
Query: 223 TLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEV 282
++ ADA + + +G++LQN+ILTLMS+ A IYK PSI N I+++VVK++++ E+ GP +
Sbjct: 263 IMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVI 322
Query: 283 SDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICD 342
+ +G TL+NFC+WQ+ N D HP H+DTA+L+TR++ C + C+ LG++ +GTICD
Sbjct: 323 NFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICD 382
Query: 343 PNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT 402
P +SC + E++GL +A T+AHELGH L + HDD+ C + + K+HVMAP
Sbjct: 383 PLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFHMSP 440
Query: 403 LPWSPCSAMYLTELLDGGHGDCLLDAPAAAL-PLPTGLPGRMALYQLDQQCRQIFGPDFR 461
WS CS Y+TE LD G+G+CLLD P + LP+ LPG + Y ++QC FGP +
Sbjct: 441 WSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPG--SRYDGNKQCELAFGPGSQ 498
Query: 462 HCPNTSAQDVCAQLWC-HTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVER 520
CP+ ++C LWC T+ C T++ +P ADGT CGPG C G C+ +E R
Sbjct: 499 MCPHI---NICMHLWCTSTEKLHKGCFTQH--VPPADGTDCGPGMHCRHGLCVNKETETR 553
Query: 521 PKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEEC 580
P +G W PW P+ CSRTCGGG++ + R C PEP+NGG YC+GRR K++SC+T+ C
Sbjct: 554 P---VNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Query: 581 PPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVF 638
P + FRE+QC +N + D+ G + ++W+P+Y+G+ +DRCKL+C+ G + F +
Sbjct: 611 PKGTQDFREKQCSDFNG-KHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLL 669
Query: 639 EAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTP 698
+ V DGT CG ET ICV+GQC+ AGCDHV++S K+DKCGVCGG +SC+ ++G
Sbjct: 670 KDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS 729
Query: 699 TNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDIL 758
++YGYN +V IPAGATN+D++Q S+ G Q D +YLAL A+G +L NGN +S +++I
Sbjct: 730 SHYGYNVVVKIPAGATNVDIRQYSYSG-QPDDSYLALSDAEGNFLFNGNFLLSTSKKEIN 788
Query: 759 VKG--TILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSM 816
V+G T+++YSGS +ER+ S + L +Q+L V G ++ P V Y+F +P
Sbjct: 789 VQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCV-GNLYNPDVHYSFNIP------- 840
Query: 817 QSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC 859
+ER+ P G W C+ C G QRR + C
Sbjct: 841 --LEERSDMFTWDP-------YGPWEGCTKMC-QGLQRRNITC 873
Score = 58.2 bits (139), Expect = 3e-08
Identities = 23/54 (42%), Positives = 32/54 (59%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
QW G W CSS+C G Q R V C+D +GQ+++ C+ A KP + + C CP
Sbjct: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
Score = 51.2 bits (121), Expect = 4e-06
Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 828 IQPLLH-AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQL 886
I LH A W +G WS+CS TCG G +R V+C G +S C LKP K C +
Sbjct: 1649 INSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYAND 1708
Query: 887 C 887
C
Sbjct: 1709 C 1709
Score = 50.4 bits (119), Expect = 7e-06
Identities = 23/56 (41%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
QW G+W ECS TCG G + R V C+ P+GQ C KP C CP
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACP 1416
Score = 49.7 bits (117), Expect = 1e-05
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECR-DPSGQASATCNKALKPEDAKPCESQLC 887
W +WSEC TCG G ++R V C+ + + CN + KPE PCE C
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA---SATCNKALKPEDAKPCESQLC 887
A W +G W C++TCG G+Q R V+C + A C++A +P D + C C
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 43.5 bits (101), Expect = 9e-04
Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECR-DPSGQ-ASATCNKALKPEDAKPCESQLC 887
W W+ECS TCG+G Q+R V CR GQ C+++ +P + C SQ C
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 507 CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQ---NGGR 563
C S PE + P P + G WGECS+TCGGG++ C+ P Q +
Sbjct: 1342 CDAASKPPELQQCGPGPCPQWNY---GNWGECSQTCGGGIKSRLVICQFPNGQILEDHNC 1398
Query: 564 YCLGRRAKYQSCHTEECPPD 583
+ + CH CP D
Sbjct: 1399 EIVNKPPSVIQCHMHACPAD 1418
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 3/71 (4%)
Query: 513 LPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC--LGRRA 570
L + E + P G GPWG CS +C GG+Q C+D Q+ YC +
Sbjct: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSAS-YCDAASKPP 1349
Query: 571 KYQSCHTEECP 581
+ Q C CP
Sbjct: 1350 ELQQCGPGPCP 1360
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 7/70 (10%)
Query: 826 NIIQPLLHA-----QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPED 878
++IQ +HA W W+ CS++CG G + R V C D + C++ KP
Sbjct: 1406 SVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPT 1465
Query: 879 AKPCESQLCP 888
K C S CP
Sbjct: 1466 HKACRSVRCP 1475
Score = 40.0 bits (92), Expect = 0.010
Identities = 16/28 (57%), Positives = 18/28 (64%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD 861
AQW G W+ CS +CG G Q R V CRD
Sbjct: 1154 AQWRHGSWTPCSVSCGRGTQARYVSCRD 1181
Score = 39.3 bits (90), Expect = 0.016
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT-CNKALKPEDAKPCESQLCP 888
+W GDWS CS++CG G R V C + C+ ++P + C CP
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
Score = 37.7 bits (86), Expect = 0.048
Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 8/107 (7%)
Query: 449 DQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCS 508
D +C+++ +C S W ++ +E L G+ HL S
Sbjct: 1003 DNECQELSRVTRENCNEFSCPS-----WAASEWSECLVTCGKGTKQRQVWCQLNVDHL-S 1056
Query: 509 EGSCLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHREC 553
+G C + E P A W GPWG C+ TCG G Q +C
Sbjct: 1057 DGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKC 1103
Score = 35.4 bits (80), Expect = 0.24
Identities = 33/143 (23%), Positives = 50/143 (34%), Gaps = 26/143 (18%)
Query: 494 PWAD-GTPCGPGHLCSEGSCLPE----------EEVERP------KPVADGGWAPWGPWG 536
PW CG G E C+ + +V++P + V W W
Sbjct: 1425 PWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKA-NSWN 1483
Query: 537 ECSRTCGGGVQFSHRECK--------DPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFR 588
ECS TCG GVQ C+ + R C RR Q C + G+
Sbjct: 1484 ECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNC 1543
Query: 589 EQQCEKYNAYNYTDMDGNLLQWV 611
CE+ +++ + N ++ V
Sbjct: 1544 STSCERKDSHQRMECTDNQIRQV 1566
Score = 32.3 bits (72), Expect = 2.0
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 3/56 (5%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
+W +WS+CS +CG G + R C + G A C + L + C CP
Sbjct: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQE-LSRVTRENCNEFSCP 1023
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 452 bits (1164), Expect = e-127
Identities = 320/929 (34%), Positives = 453/929 (48%), Gaps = 98/929 (10%)
Query: 3 PAPAAPRWPPLLLLLLLLLPLARG-APARPAAGGQASELVVPTRLPGSAGELALHL---- 57
P AP PLLLLL L P A G AP R G A ++V P R+ L+ L
Sbjct: 7 PRSPAPLLRPLLLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRA 66
Query: 58 ------------SAF------GKGFVLRLAPDDSFLAPEFKIE--RLGGSGRATGGERGL 97
AF G+ L + LAP F E R GG GRA
Sbjct: 67 LRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAH-T 125
Query: 98 RGCFFSGTVNGEPE---SLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSL---AQPHRLQ 151
C G V +PE LAA+S C GL G F L E++ I+P + + AQPH +
Sbjct: 126 PACHLLGEVQ-DPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVY 184
Query: 152 RWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRT 211
+ + PE + G+ Q E ES+ E E + P
Sbjct: 185 K---------RQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPR-LRRLH 234
Query: 212 KRFVSEARFVETLLVADASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKV 270
+R VS+ ++VETL+VADA M ++G +++++LT+M++ A ++ PSI N I++ +V++
Sbjct: 235 QRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRL 294
Query: 271 LIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGL-C 329
+++EDE+ +++ + TL++FC WQ+ N D HP H+DTAILLTR++ C C
Sbjct: 295 VLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPC 354
Query: 330 DTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDS-KPCTRLFGPMGK 388
+TLG++ + +C P++SCS+ ED GL A T+AHELGH + HD S C P+GK
Sbjct: 355 ETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCE----PVGK 410
Query: 389 H-HVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAA-ALPLPTGLPGRMALY 446
+M+P ++ L WS CS Y+T LD G G CL D PA + P+ PG LY
Sbjct: 411 RPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPG--VLY 468
Query: 447 QLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHL 506
+ QCR +G C + +VC LWC CH+K + DGT CG
Sbjct: 469 DVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---CHSKLDAA--VDGTRCGENKW 521
Query: 507 CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCL 566
C G C+P RP+ V DGGW+ W W CSR+CG GVQ + R+C P P+ GRYC+
Sbjct: 522 CLSGECVPVGF--RPEAV-DGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCV 578
Query: 567 GRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLF 626
G R +++ C+ + CP SFR QC ++A Y G L WVP V+P C+L
Sbjct: 579 GERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY---KGQLHTWVPVVNDVNP---CELH 632
Query: 627 CRARGRSEFKVFEAKVIDGTLCGPETLA--ICVRGQCVKAGCDHVVDSPRKLDKCGVCGG 684
CR + V+DGT C + +C+ G C GCD +DS D+CGVC G
Sbjct: 633 CRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHG 692
Query: 685 KGNSCRKVSGSLTPT-NYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQ-Y 742
G++C VSG+ GY D+ IPAGA I +++ V N+LAL++ D + Y
Sbjct: 693 NGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE-----VAEAANFLALRSEDPEKY 747
Query: 743 LLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKV 802
LNG I D V GT Y+ E L S P EP+ +QLL P V
Sbjct: 748 FLNGGWTIQ-WNGDYQVAGTTFTYARR-GNWENLTSPGPTKEPVWIQLLFQESN---PGV 802
Query: 803 KYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC--R 860
Y + + +E + + P + + W G W++C+ TCG G QR+ V C R
Sbjct: 803 HYEYTI----------HREAGGHDEVPPPVFS-WHYGPWTKCTVTCGRGVQRQNVYCLER 851
Query: 861 DPSGQASATCNKALKPED-AKPCESQLCP 888
C+ +P+D + C Q CP
Sbjct: 852 QAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Score = 52.4 bits (124), Expect = 2e-06
Identities = 23/54 (42%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
A W +G+WS+CS TCG G QRR V C + +G C++A +P C LC
Sbjct: 944 ATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG---VPCDEAQQPASEVTCSLPLC 994
Score = 50.8 bits (120), Expect = 5e-06
Identities = 23/59 (38%), Positives = 29/59 (49%), Gaps = 7/59 (11%)
Query: 829 QPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
QP L W W ECS CG G Q+R V C +P C +AL+P +PC + C
Sbjct: 1519 QPCL--SWYTSSWRECSEACGGGEQQRLVTCPEP-----GLCEEALRPNTTRPCNTHPC 1570
Score = 50.1 bits (118), Expect = 9e-06
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPS----GQASATCNKALKPEDAKPCESQLC 887
QWV+G W +CS CG G QRR V+C + + S C PE ++PC ++ C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/130 (32%), Positives = 54/130 (41%), Gaps = 26/130 (20%)
Query: 477 CHTDGAEPLCHTKNGSLP--------WAD-GTPCGPGHLCSEGSCLPE----EEVERP-- 521
C A+P H G+ P W + CG G +C PE EE RP
Sbjct: 1503 CQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-PEPGLCEEALRPNT 1561
Query: 522 -KPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPE---PQNGGRYCLGRRAKYQS- 574
+P W GPWG+CS CGGGVQ +C + + P+ C G A +S
Sbjct: 1562 TRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQC-GHEAWPESS 1620
Query: 575 --CHTEECPP 582
C TE+C P
Sbjct: 1621 RPCGTEDCEP 1630
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 833 HAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
+A W G+WSECS+TCG G R V C S C A +P+ A+ C + C
Sbjct: 1412 NAGWQAGNWSECSTTCGLGAVWRPVRC---SSGRDEDCAPAGRPQPARRCHLRPC 1463
Score = 40.0 bits (92), Expect = 0.010
Identities = 22/58 (37%), Positives = 28/58 (48%), Gaps = 4/58 (6%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKA-LKPEDAKPCESQLC 887
A W G+WS+CS +CG G R V+C RD C KP +PC +Q C
Sbjct: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Score = 35.8 bits (81), Expect = 0.18
Identities = 27/84 (32%), Positives = 34/84 (40%), Gaps = 13/84 (15%)
Query: 521 PKPVADGGWAPWGPWGECSRTCGGGVQFSHREC---KDPEPQNGGRYCLGRRAKYQSCHT 577
P V + GW G W ECS TCG G + C +D + GR RR + C T
Sbjct: 1407 PLVVRNAGWQA-GNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCAT 1465
Query: 578 ------EECPPD---GKSFREQQC 592
+C G S R+ QC
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQC 1489
Score = 35.4 bits (80), Expect = 0.24
Identities = 26/75 (34%), Positives = 33/75 (44%), Gaps = 17/75 (22%)
Query: 495 WAD-GTPCGPGHL-----CSEG---SCLPEEEVERPKPVADGGWAP---W--GPWGECSR 540
W++ T CG G + CS G C P RP+P P W G W +CSR
Sbjct: 1420 WSECSTTCGLGAVWRPVRCSSGRDEDCAP---AGRPQPARRCHLRPCATWHSGNWSKCSR 1476
Query: 541 TCGGGVQFSHRECKD 555
+CGGG +C D
Sbjct: 1477 SCGGGSSVRDVQCVD 1491
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 430 bits (1106), Expect = e-120
Identities = 285/860 (33%), Positives = 434/860 (50%), Gaps = 77/860 (8%)
Query: 46 LPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE-RLGGSGRATGGERGLRGCFFSG 104
L GS + +S K L + FL+ + +E R G C SG
Sbjct: 84 LDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSG 143
Query: 105 TV--NGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWG--PAGARP 160
TV G AA+S C GL+G F L +F I+P + H L G P
Sbjct: 144 TVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEP-------VKKHPLVEGGYHPHIVYR 196
Query: 161 LPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARF 220
+ PE + T +DS SQ++E L + S ++R +S+ R+
Sbjct: 197 RQKVPETKEPTCG---------LKDSVNISQKQELWREKWERHNLPSRSLSRRSISKERW 247
Query: 221 VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWG 279
VETL+VAD M ++G++ ++++ILT+M++ ++ +PSI N+I+++VV+++++E+E+ G
Sbjct: 248 VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQG 307
Query: 280 PEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFC-GQEGLCDTLGVADIG 338
++ + TL +FC WQ+ N SD +P H+D A+LLTR++ C G C+TLG++ +
Sbjct: 308 LKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLS 367
Query: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKH-HVMAPLFV 397
+C P++SC++ ED GL A T+AHELGH + HD + P+G+H ++M+
Sbjct: 368 GMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCE---PVGRHPYIMSRQLQ 424
Query: 398 HLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAA-ALPLPTGLPGRMALYQLDQQCRQIF 456
+ L WS CS Y+T LD G G CL D P L PG +Y + QC+ +
Sbjct: 425 YDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPG--VIYDVHHQCQLQY 482
Query: 457 GPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEE 516
GP+ C ++VC LWC G C +K + ADGT CG C G C+
Sbjct: 483 GPNATFCQEV--ENVCQTLWCSVKG---FCRSKLDAA--ADGTQCGEKKWCMAGKCITVG 535
Query: 517 EVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCH 576
+ P GGW W PW CSRTCG GVQ + R C +PEP+ GG+YC G R +Y+ C+
Sbjct: 536 KKPESIP---GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCN 592
Query: 577 TEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCR-ARGRSEF 635
C + +FR+ QC +++ Y + L W P + +P C+L+CR G+
Sbjct: 593 VHPCRSEAPTFRQMQCSEFDTVPYKN---ELYHWFPIF---NPAHPCELYCRPIDGQFSE 646
Query: 636 KVFEAKVIDGTLC--GPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVS 693
K+ +A VIDGT C G + +C+ G C GCD+ +DS D+CGVC G G+SC+ V
Sbjct: 647 KMLDA-VIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVR 705
Query: 694 GSL-TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQ-YLLNGNLAIS 751
GY DI IP GA +I V + ++ GN+LA+++ D + Y LNG I
Sbjct: 706 KMFKQKEGSGYVDIGLIPKGARDIRVME-----IEGAGNFLAIRSEDPEKYYLNGGFIIQ 760
Query: 752 AIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND 811
+ + GT+ +Y LE+L + P E + +QLL +V P +KY + + D
Sbjct: 761 -WNGNYKLAGTVFQYDRK-GDLEKLMATGPTNESVWIQLLF---QVTNPGIKYEYTIQKD 815
Query: 812 VDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQASAT- 869
N ++ ++ W G W+ECS TCG G +R+T C + G AT
Sbjct: 816 -----------GLDNDVEQQMYF-WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATF 863
Query: 870 CNKALKPED-AKPCESQLCP 888
C+ +P K C + CP
Sbjct: 864 CDPETQPNGRQKKCHEKACP 883
Score = 53.1 bits (126), Expect = 1e-06
Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
A W++G+WSECS+TCG G R VEC S Q + C +P+ AK C + C
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC---STQMDSDCAAIQRPDPAKRCHLRPC 1365
Score = 51.6 bits (122), Expect = 3e-06
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 5/74 (6%)
Query: 819 SKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSG-----QASATCNKA 873
+K +T L W G+W CS++CG G+Q+RTV+C G Q C+
Sbjct: 1458 TKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHK 1517
Query: 874 LKPEDAKPCESQLC 887
+P + K C Q C
Sbjct: 1518 PRPPEFKKCNQQAC 1531
Score = 45.1 bits (105), Expect = 3e-04
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 3/58 (5%)
Query: 831 LLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
L + W +G+WSECS +CG G + R+V C + C+ KP C Q CP
Sbjct: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC---AKNHDEPCDVTRKPNSRALCGLQQCP 997
Score = 39.3 bits (90), Expect = 0.016
Identities = 19/52 (36%), Positives = 24/52 (46%), Gaps = 6/52 (11%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
W + WS+CS +CG G Q R V C P G C+ +P C LC
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFC--PGG----LCDWTKRPTSTMSCNEHLC 1472
Score = 37.7 bits (86), Expect = 0.048
Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 20/63 (31%)
Query: 532 WGPWGECSRTCGGGVQFSHRECK------------DPEPQNGGRYCLGRRAKYQSCHTEE 579
+G W ECS TCG G++ C DPE Q GR + CH +
Sbjct: 830 YGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQ--------KKCHEKA 881
Query: 580 CPP 582
CPP
Sbjct: 882 CPP 884
Score = 36.2 bits (82), Expect = 0.14
Identities = 12/28 (42%), Positives = 19/28 (67%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD 861
A W +G+WS+CS C G++ R ++C D
Sbjct: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVD 1393
Score = 35.4 bits (80), Expect = 0.24
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 18/83 (21%)
Query: 490 NGSLPWADG------TPCGPGHLCSEGSCLPEEE-----VERPKPVAD------GGWAPW 532
+GS W G T CG G C + + ++RP P GW
Sbjct: 1312 HGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKV- 1370
Query: 533 GPWGECSRTCGGGVQFSHRECKD 555
G W +CSR C GG + +C D
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCVD 1393
Score = 34.3 bits (77), Expect = 0.53
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 13/69 (18%)
Query: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQS---CHTEECPPDGK 585
WA G W CS +CGGG Q +C E G + + Q C + PP+ K
Sbjct: 1475 WAT-GNWDLCSTSCGGGFQKRTVQCVPSE---------GNKTEDQDQCLCDHKPRPPEFK 1524
Query: 586 SFREQQCEK 594
+Q C+K
Sbjct: 1525 KCNQQACKK 1533
Score = 33.5 bits (75), Expect = 0.90
Identities = 11/14 (78%), Positives = 13/14 (92%)
Query: 534 PWGECSRTCGGGVQ 547
PW +CSR+CGGGVQ
Sbjct: 1431 PWSQCSRSCGGGVQ 1444
Score = 30.4 bits (67), Expect = 7.6
Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 6/51 (11%)
Query: 533 GPWGECSRTCGGGVQFSHREC--KDPEPQNGGRYCLGRRAKYQSCHTEECP 581
G W ECS +CGGGV+ C EP + R R C ++CP
Sbjct: 951 GNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRAL----CGLQQCP 997
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif,
6 preproprotein [Homo sapiens]
Length = 1117
Score = 412 bits (1059), Expect = e-115
Identities = 284/878 (32%), Positives = 428/878 (48%), Gaps = 96/878 (10%)
Query: 49 SAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNG 108
+ +L LSA+GK F L L + F++ F +E G G + L C ++G +
Sbjct: 81 AVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF-LDNCHYTGYLQD 139
Query: 109 EPESL-AAVSLCRGLSGSFLLDGEEFTIQP--------QGAGGSLAQPHRLQRWGPAGAR 159
+ + A+S C GL G + EE+ I+P + PH + + R
Sbjct: 140 QRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQR 199
Query: 160 PLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEAR 219
L V + R + D+ S S P R KR VS R
Sbjct: 200 HLYDHSHCGVS--DFTRSGKPWWLNDTSTVSY-------SLPINNTHIHHRQKRSVSIER 250
Query: 220 FVETLLVADASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKW 278
FVETL+VAD M ++G D++++IL++M++ A++Y+ S+ N +N++V +++++ +++
Sbjct: 251 FVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP 310
Query: 279 GPEVSDNGGLTLRNFCNWQRRF-NQPSDRH--PE----HYDTAILLTRQNFCGQEGL-CD 330
E++ + +L +FC WQ+ + SD + PE H+D A+L+TR + C + C
Sbjct: 311 NLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCG 370
Query: 331 TLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHH 390
TLG+A + +C+P +SCS+ ED GL +A T+AHE+GH M HD G
Sbjct: 371 TLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKL 430
Query: 391 VMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCL-LDAPAAALPLPTGLPGRMALYQLD 449
+ A + + N WS CS Y+T LD G G CL + P P PG++ Y D
Sbjct: 431 MAAHITANTNP-FSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQV--YDAD 487
Query: 450 QQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHL--- 506
+QCR +G R C +VC +LWC + C T S+P A+GT C G++
Sbjct: 488 EQCRFQYGATSRQC---KYGEVCRELWCLSKSNR--CVTN--SIPAAEGTLCQTGNIEKG 540
Query: 507 -CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC 565
C +G C+P P+ + DGGW PW WGECSRTCGGGV S R C P P GG+YC
Sbjct: 541 WCYQGDCVPFGTW--PQSI-DGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
Query: 566 LGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVP-KYAGVSPRDRCK 624
LG R +Y+SC+T+ CP + FRE+QC ++ + G W P GV P C
Sbjct: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR---GKYYNWKPYTGGGVKP---CA 651
Query: 625 LFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGG 684
L C A G + + VIDGT C ++L IC+ G+C GCD+++ S + D+C VCGG
Sbjct: 652 LNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGG 711
Query: 685 KGNSCRKVSGSLTPT--NYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQY 742
G++C + G + GY ++V IP G+ +I+V++ V NY+ALK+ Y
Sbjct: 712 DGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVRE-----VAMSKNYIALKSEGDDY 766
Query: 743 LLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKV 802
+NG I + V GT Y E L++ P E L V +L + +
Sbjct: 767 YINGAWTID-WPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNL---GI 822
Query: 803 KYTFFVP--------NDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
+Y F VP N+V F+ W WSECS+TC G QR
Sbjct: 823 RYKFNVPITRTGSGDNEVGFT--------------------WNHQPWSECSATCAGGVQR 862
Query: 855 RTVECR---DPSGQASATCNKALK-PEDAKPCESQLCP 888
+ V C+ D S + C+ K PE+ + C ++ CP
Sbjct: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Score = 62.0 bits (149), Expect = 2e-09
Identities = 24/51 (47%), Positives = 35/51 (68%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQ 885
+WV GDW +CS+ CG G Q RTV+C +GQAS+ C + ++P + CES+
Sbjct: 1021 RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK 1071
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/59 (42%), Positives = 31/59 (52%), Gaps = 7/59 (11%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKP-----CESQLCP 888
QWV DWSEC+ CG G++ R V C+ S S T A PE++KP C CP
Sbjct: 962 QWVALDWSECTPKCGPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Score = 42.0 bits (97), Expect = 0.003
Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 534 PWGECSRTCGGGVQFSHRECK--DPEPQNGGRYC---LGRRAKYQSCHTEECPPD 583
PW ECS TC GGVQ CK D YC ++C+TE CPP+
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
Score = 33.5 bits (75), Expect = 0.90
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 6/66 (9%)
Query: 533 GPWGECSRTCGGGVQFSHREC---KDPEPQNGGRY--CLGRR-AKYQSCHTEECPPDGKS 586
G W ECS+TC GG++ C P + Y CL R + + C+ + CPP +
Sbjct: 906 GDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVA 965
Query: 587 FREQQC 592
+C
Sbjct: 966 LDWSEC 971
Score = 33.1 bits (74), Expect = 1.2
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 19/81 (23%)
Query: 492 SLPWADGTP-CGPGH-----LCSEGSC--------LPEEEVERPKPVADGGWAP---W-- 532
+L W++ TP CGPG LC PEE + G P W
Sbjct: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
Query: 533 GPWGECSRTCGGGVQFSHREC 553
G WG+CS CG G Q +C
Sbjct: 1025 GDWGQCSAQCGLGQQMRTVQC 1045
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 405 bits (1042), Expect = e-113
Identities = 287/882 (32%), Positives = 420/882 (47%), Gaps = 92/882 (10%)
Query: 53 LALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPES 112
L SAFG+ L L P + L+ F ++ LG G + + ++ CF+ G + + S
Sbjct: 97 LHYRFSAFGQELHLELKPS-AILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSS 155
Query: 113 LAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARP---LPRGPEWEV 169
AVS C GLSG EF I P LAQ H PAG P R E ++
Sbjct: 156 SVAVSTCAGLSGLIRTRKNEFLISPLPQ--LLAQEHNYS--SPAGHHPHVLYKRTAEEKI 211
Query: 170 ETGEGQ----RQERGDHQEDSEEESQEEEAEGASE---------------PPPPL----- 205
+ G R G SQ E E P PP
Sbjct: 212 QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYL 271
Query: 206 -----GATSRTKRFVSEARF---VETLLVADASMAAFYG-ADLQNHILTLMSVAARIYKH 256
G++ R +R +++ VETL+VAD M +G ++ +ILT+M++ + ++K
Sbjct: 272 RFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKD 331
Query: 257 PSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAIL 316
+I + IN++VV ++++E E G ++ + +L +FC WQ ++ + +D AIL
Sbjct: 332 GTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL---IGKNGKRHDHAIL 388
Query: 317 LTRQNFCGQEGL-CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHD- 374
LT + C + CDTLG A I +C +SC++ ED GL A T+AHE GH M HD
Sbjct: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
Query: 375 DSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAP--AAA 432
+ PC + G ++M+P N WS CS YL + L CL+D P A
Sbjct: 449 EGNPCRKAEG-----NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQ 503
Query: 433 LPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGS 492
P LPG+ +Y D QC+ FG + C +D+C LWCH G C TK
Sbjct: 504 YKYPDKLPGQ--IYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR--CETK--F 557
Query: 493 LPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRE 552
+P A+GT CG C +G C+ E+ P+P+ G W+ W W ECSRTCGGGV+F R
Sbjct: 558 MPAAEGTVCGLSMWCRQGQCVKFGELG-PRPI-HGQWSAWSKWSECSRTCGGGVKFQERH 615
Query: 553 CKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVP 612
C +P+PQ GG +C G YQ C+ C + FR QQC +YN+ + G QW P
Sbjct: 616 CNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR---GWFYQWKP 672
Query: 613 KYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDS 672
Y V DRCKL+C+A F KV DGT C P +C+ G C GCDH + S
Sbjct: 673 -YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGS 731
Query: 673 PRKLDKCGVCGGKGNSCRKVSGSLTPTNYG--YNDIVTIPAGATNIDVKQRSHPGVQNDG 730
D CGVC G ++C+ G + Y +V IPAGA +I++++ +Q
Sbjct: 732 KAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE-----LQVSS 786
Query: 731 NYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQL 790
+YLA+++ +Y L G +I + GT +Y S ERL + P E L ++
Sbjct: 787 SYLAVRSLSQKYYLTGGWSID-WPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEI 845
Query: 791 LTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERA-TTNIIQPLLHAQWVLGDWSECSSTCG 849
L + G+ P + + + +P ++ + ++K A T +I+Q SECS +CG
Sbjct: 846 L-MQGK--NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ------------SECSVSCG 890
Query: 850 AGWQRRTVEC-RDPSGQA-SATCNKALKP-EDAKPCESQLCP 888
G+ C RD + Q S+ C+ KP + K C + CP
Sbjct: 891 GGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCP 888
QW LG WS+CS TCG G ++R + C+ + + + C +PE + C CP
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCP 1049
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
A W W +C+ TCG G Q R+V C G+ S++C KP + C + CP
Sbjct: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 43.9 bits (102), Expect = 7e-04
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 8/62 (12%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA------SATCNKALKP--EDAKPCESQL 886
QWV WSECS+TCG G ++R ++C + Q C KP + + C +
Sbjct: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRA 1114
Query: 887 CP 888
CP
Sbjct: 1115 CP 1116
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/118 (24%), Positives = 44/118 (37%), Gaps = 25/118 (21%)
Query: 501 CGPGHLCSEGSCLPEEEVE--------RPKPVAD----------GGWAPWGPWGECSRTC 542
CG G++ + CL ++ + + KPV + W P G W CS+ C
Sbjct: 889 CGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMP-GEWSTCSKAC 947
Query: 543 GGGVQFSHRECKDPEPQNGGRYCL------GRRAKYQSCHTEECPPDGKSFREQQCEK 594
GG Q +C +P L + Q+C++ CPP QC K
Sbjct: 948 AGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSK 1005
Score = 35.0 bits (79), Expect = 0.31
Identities = 49/201 (24%), Positives = 66/201 (32%), Gaps = 36/201 (17%)
Query: 404 PWSPCS-----AMYLTELL-DGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFG 457
PWS CS + ELL G + L ++ +LP P +L + C + G
Sbjct: 999 PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP----------ELQEGC--VLG 1046
Query: 458 PDFRHCPNTSAQDVCAQLWCHTDGA--------EPLCHTKN--GSLPWADGTPCG---PG 504
CP S A W E C K G L C
Sbjct: 1047 ----RCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
Query: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
+L E +C P GW PW +C+ TCGGGVQ C +
Sbjct: 1103 NLDLEETCNRRACPAHPVYNMVAGWYSL-PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCL 1161
Query: 565 CLGRRAKYQSCHTEECPPDGK 585
+ ++C+T CP K
Sbjct: 1162 LHQKPPVLRACNTNFCPAPEK 1182
Score = 34.7 bits (78), Expect = 0.40
Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 9/59 (15%)
Query: 533 GPWGECSRTCGGGVQFSHRECKD------PEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
GPW +CS+TCG GV+ CK PE Q L R + C CP + +
Sbjct: 998 GPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS---LPRPELQEGCVLGRCPKNSR 1053
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 402 bits (1032), Expect = e-111
Identities = 281/863 (32%), Positives = 423/863 (49%), Gaps = 102/863 (11%)
Query: 64 FVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRG-CFFSGTVNGEPE-SLAAVSLCRG 121
F+L L LA +E G A +R R C ++G + G+ S A+S C G
Sbjct: 87 FLLNLTRSSRLLAGHVSVEYWTREGLAW--QRAARPHCLYAGHLQGQASTSHVAISTCGG 144
Query: 122 LSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGAR-PLPRGPEWEVETGEGQRQERG 180
L G + D EE+ I+P G P G+R P GP + + R
Sbjct: 145 LHGLIVADEEEYLIEPLHGG-------------PKGSRSPEESGPHVVYK----RSSLRH 187
Query: 181 DHQEDSEEESQEEEAEGAS------EPPP--PLGATSRT-----KRFVSEARFVETLLVA 227
H + + E+ +G +PPP PLG + KR VS R+VETL+VA
Sbjct: 188 PHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVA 247
Query: 228 DASMAAFYGA-DLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNG 286
D M A++G D++ ++L +M++ A++++ S+ +++N++V +++++ +++ E++ +
Sbjct: 248 DKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA 307
Query: 287 GLTLRNFCNWQRRF-------NQPSDRHPEHYDTAILLTRQNFCGQEGL-CDTLGVADIG 338
G +L +FC WQ+ N + ++DTA+L+TR + C + C TLG+A +G
Sbjct: 308 GKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLAPVG 367
Query: 339 TICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDD-SKPCTRLFGPMGKH--HVMAPL 395
+C+ +SCSV ED GL A T+AHE+GH M HD C G G+ +MA
Sbjct: 368 GMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSC----GARGQDPAKLMAAH 423
Query: 396 FVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPTGLPGRMALYQLDQQCRQ 454
WS CS Y+T LD G G CL + P PT PG+ Y D+QCR
Sbjct: 424 ITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQA--YDADEQCRF 481
Query: 455 IFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLP 514
G R C +VC++LWC + C T S+P A+GT C H +G C
Sbjct: 482 QHGVKSRQC---KYGEVCSELWCLSKSNR--CITN--SIPAAEGTLCQT-HTIDKGWCYK 533
Query: 515 EEEV---ERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAK 571
V RP+ V DG W PW PWG+CSRTCGGGV S R C P P GG+YCLG R +
Sbjct: 534 RVCVPFGSRPEGV-DGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRR 592
Query: 572 YQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARG 631
++SC+T++CPP + FRE QC ++++ + G +W Y G + C L C A G
Sbjct: 593 HRSCNTDDCPPGSQDFREVQCSEFDSIPFR---GKFYKW-KTYRGGGVK-ACSLTCLAEG 647
Query: 632 RSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRK 691
+ + A V+DGT C P+T+ ICV G+C GCD V+ S + DKC VCGG G++C
Sbjct: 648 FNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACET 707
Query: 692 VSGSLTPTN--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLA 749
+ G +P + GY D+V IP G+ +I ++ + ++LALK D + LL L
Sbjct: 708 IEGVFSPASPGAGYEDVVWIPKGSVHIFIQD-----LNLSLSHLALK-GDQESLLLEGLP 761
Query: 750 ISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
+ + + GT + ++ L++ P+ L V +L P ++Y F P
Sbjct: 762 GTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVL---ARTELPALRYRFNAP 818
Query: 810 NDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECR---DPSGQA 866
D L W W++CS+ C G Q + VECR D S A
Sbjct: 819 IARD----------------SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVA 862
Query: 867 SATCNKALK-PEDAKPCESQLCP 888
C+ K P+ + C ++ CP
Sbjct: 863 PHYCSAHSKLPKRQRACNTEPCP 885
Score = 62.8 bits (151), Expect = 1e-09
Identities = 24/52 (46%), Positives = 36/52 (69%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQ 885
A+WV G+W ECS+ CG G ++R+V C +GQAS C +AL+P + CE++
Sbjct: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK 1056
Score = 48.1 bits (113), Expect = 4e-05
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 830 PLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS---ATCNKALKPEDAKPCESQL 886
P +W DWSEC+ +CG G + R V C+ +A+ A C+ A KP C +
Sbjct: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
Query: 887 CP 888
CP
Sbjct: 1002 CP 1003
Score = 41.2 bits (95), Expect = 0.004
Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 532 WGPWGECSRTCGGGVQFSHRECKDPEPQNG--GRYCLGRRA---KYQSCHTEECPPD 583
+ PW +CS C GG Q EC++ + YC + ++C+TE CPPD
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD 887
Score = 35.0 bits (79), Expect = 0.31
Identities = 23/94 (24%), Positives = 36/94 (38%), Gaps = 7/94 (7%)
Query: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECK------DPEP 558
H CS S LP+ + W G W CSR+C GV+ C+ + +
Sbjct: 864 HYCSAHSKLPKRQRACNTEPCPPDWVV-GNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKA 922
Query: 559 QNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQC 592
+ R ++CH CPP+ + +C
Sbjct: 923 LDDSACPQPRPPVLEACHGPTCPPEWAALDWSEC 956
Score = 31.6 bits (70), Expect = 3.4
Identities = 28/81 (34%), Positives = 33/81 (40%), Gaps = 19/81 (23%)
Query: 484 PLCHTKNGSLPWADGTP-CGPGH-----LCSEG---SCLPEEEVE-RPKPVADGGW---- 529
P C + +L W++ TP CGPG LC + LP KP A
Sbjct: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRR 1001
Query: 530 ---APW--GPWGECSRTCGGG 545
A W G WGECS CG G
Sbjct: 1002 CPPARWVAGEWGECSAQCGVG 1022
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 379 bits (972), Expect = e-105
Identities = 297/952 (31%), Positives = 431/952 (45%), Gaps = 151/952 (15%)
Query: 25 RGAPARPAA--GGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE 82
R AP R + GG E PGS L +++ FG+ LRL P+ +AP +E
Sbjct: 88 RAAPVRTPSFPGGNEEE-------PGS--HLFYNVTVFGRDLHLRLRPNARLVAPGATME 138
Query: 83 RLGGSGRATGGERGLRGCFFSGTVNGEPE-SLAAVSLCRGLSGSFLLDGEEFTIQP--QG 139
G G T E L C + G V G E S A+S C GL+G ++ EEF I+P +G
Sbjct: 139 WQGEKG-TTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKG 197
Query: 140 AGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQ-----EEE 194
A+ R+ + R P G Q + G + + S+ EE
Sbjct: 198 LAAQEAEQGRVH--------VVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEH 249
Query: 195 AEGASEPPPPLGATSRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAAR 252
A + R +R ++ + +E LL D S+ F+G + +Q ++LTLM++
Sbjct: 250 ANSSRR---------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
Query: 253 IYKHPSIKNSINLMVVKVLIVEDEKWGPEVS----DNGGLTLRNFCNWQRRFNQPSDRHP 308
IY S+ IN+++V+++++ +G +S N +L N C W +P H
Sbjct: 301 IYHDESLGAHINVVLVRIILLS---YGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHD 357
Query: 309 EHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHV 368
E++D AI LTRQ+F G G+ G A + +C P +SC++ ++G +A +AHE GHV
Sbjct: 358 EYHDHAIFLTRQDF-GPSGM---QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHV 413
Query: 369 LSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDA 428
L M HD R + +MAPL WS CS L+ L DCLLD
Sbjct: 414 LGMEHDGQG--NRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDD 469
Query: 429 PAA----ALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEP 484
P A ALP GL Y +++QCR FG + C D C QLWC
Sbjct: 470 PFAHDWPALPQLPGLH-----YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY 524
Query: 485 LCHTKNGSLPWADGTPCGPGHLCSEGSC--LPEEEVERPKPVADGGWAPWGPWGECSRTC 542
C TK G P DGT C PG C +G C L + ++R DG W W P+G CSRTC
Sbjct: 525 FCKTKKG--PPLDGTMCAPGKHCFKGHCIWLTPDILKR-----DGSWGAWSPFGSCSRTC 577
Query: 543 GGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAY-NYT 601
G GV+F R+C +P P NGGR C G +Q C ++CP FRE+QC +++ Y +
Sbjct: 578 GTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHG 637
Query: 602 DMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQ 660
D + W+P + ++RC L+C +R E + V DGT C + ++CVRG
Sbjct: 638 DAQHH---WLP-HEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGD 693
Query: 661 CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLT--PTNYGYNDIVTIPAGATNIDV 718
C K GCD V+ S ++ DKCGVCGG + C+ V G+ T P +GY + IPAGA ++ +
Sbjct: 694 CRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLI 753
Query: 719 KQRSHPGVQNDGNYLALKTAD-GQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQ 777
++ V ++LA+K + G+++LN + A + + G +Y E LQ
Sbjct: 754 QE-----VDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR-ETLQ 807
Query: 778 SFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND---VD--------------------- 813
+ PL +TV L +P + Y + + D VD
Sbjct: 808 TMGPLHGTITV--LVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSP 865
Query: 814 ----------------------------FSMQSSKERATTNIIQPLLHAQ--WVLGDWSE 843
F SK +A P +Q WV G+W
Sbjct: 866 CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEP 925
Query: 844 CSSTCG-AGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
CS TCG G Q R+V C P + CN A +PE + C +LCP
Sbjct: 926 CSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Score = 45.4 bits (106), Expect = 2e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 831 LLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
L +W G WS+CS TCG G Q R V CR + + C + +PE A+ C CP
Sbjct: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCR-TADDSFGICQEE-RPETARTCRLGPCP 1029
Score = 35.4 bits (80), Expect = 0.24
Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 9/80 (11%)
Query: 514 PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAK-Y 572
PE + + G W GPW +CS TCG G Q C+ + G C R +
Sbjct: 964 PESRRACSRELCPGRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETA 1020
Query: 573 QSCHTEECP-----PDGKSF 587
++C CP P KS+
Sbjct: 1021 RTCRLGPCPRNISDPSKKSY 1040
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 374 bits (959), Expect = e-103
Identities = 272/873 (31%), Positives = 404/873 (46%), Gaps = 84/873 (9%)
Query: 52 ELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGS---------------GRATGGERG 96
+L +++AFGK F LRL P+ +AP +E S G AT R
Sbjct: 79 QLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRK 138
Query: 97 LR----GCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQP----H 148
C + G + P + A+S C GL+G D EE+ I+P G + + H
Sbjct: 139 TEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIH 198
Query: 149 RLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGAT 208
+ + P+ ++ H +S+ E ++ L T
Sbjct: 199 VVYKRSAVEQAPIDMSKDF--------------HYRESDLEGLDDLGTVYGNIHQQLNET 244
Query: 209 SRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLM 266
R +R E + +E LL D S+ F+G + +QN++LTLM++ IY S+ IN++
Sbjct: 245 MRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVV 304
Query: 267 VVKVLIVEDEKWGPEVS-DNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQ 325
+V+++++ K + N +L N C W + + H EH+D AI LTRQ+F
Sbjct: 305 LVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF--- 361
Query: 326 EGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGP 385
G G A + +C P +SC++ ++G +A +AHE GHVL M HD R
Sbjct: 362 -GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDE 418
Query: 386 MGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPTGLPGRMA 444
VMAPL WS CS L + DCLLD P P LPG
Sbjct: 419 TAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPELPG--I 474
Query: 445 LYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPG 504
Y +D+QCR FG ++ C D C QLWC C TK G P DGT C G
Sbjct: 475 NYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKG--PPLDGTECAAG 532
Query: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
C +G C+ + ++ + DG W W +G CSRTCG GV+F R+C +P P NGG+
Sbjct: 533 KWCYKGHCMWKNANQQKQ---DGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQD 589
Query: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
C G +YQ C+TEEC + FR QQC++ N ++ + W+P Y P+ RC
Sbjct: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN--SHFEYQNTKHHWLP-YEHPDPKKRCH 646
Query: 625 LFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCG 683
L+C+++ + + V DGT C + +ICVRG+CVK GCD + S + DKCGVCG
Sbjct: 647 LYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCG 706
Query: 684 GKGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKT-ADG 740
G + CR V G+ TP GY + IP GA ++ +++ + + LA+K A G
Sbjct: 707 GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQED-----EASPHILAIKNQATG 761
Query: 741 QYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPP 800
Y+LNG A + + G Y+ +E L + PL +P+ V ++ +
Sbjct: 762 HYILNGK-GEEAKSRTFIDLGVEWDYNIE-DDIESLHTDGPLHDPVIVLIIPQENDT-RS 818
Query: 801 KVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHA-QWVLGDWSECSSTCGAGWQRRTVEC 859
+ Y + + D ++ S+ N+IQ L +W L WS+CS CG G+Q C
Sbjct: 819 SLTYKYIIHEDSVPTINSN------NVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGC 872
Query: 860 RDPSG-----QASATCNKALKPEDAKPCESQLC 887
R S ++ NK KP + C Q C
Sbjct: 873 RRKSDNKMVHRSFCEANKKPKP-IRRMCNIQEC 904
Score = 47.4 bits (111), Expect = 6e-05
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 6/67 (8%)
Query: 828 IQPLLHAQWVLGDWSECSSTCG-AGWQRRTVECRDP--SGQASATCNKAL---KPEDAKP 881
IQ H WV +W C+ TCG +G+Q RTV C P G + +K +PE +P
Sbjct: 901 IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP 960
Query: 882 CESQLCP 888
C CP
Sbjct: 961 CNRVPCP 967
Score = 45.1 bits (105), Expect = 3e-04
Identities = 24/54 (44%), Positives = 28/54 (51%), Gaps = 6/54 (11%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
AQW G WSECS TCG G + R V CR A C+ KPE + C+ C
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLCR-----AGDHCD-GEKPESVRACQLPPC 1015
Score = 37.4 bits (85), Expect = 0.062
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)
Query: 530 APW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSF 587
A W GPW ECS TCG G + C+ + +G + R + C+ E C D F
Sbjct: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIF 1027
Query: 588 REQQ 591
+ +
Sbjct: 1028 CQME 1031
Score = 31.2 bits (69), Expect = 4.5
Identities = 19/65 (29%), Positives = 27/65 (41%), Gaps = 7/65 (10%)
Query: 535 WGECSRTCG-GGVQFSHRECKDPEPQNGGR-----YCLGRRAK-YQSCHTEECPPDGKSF 587
W C++TCG G Q C P R YC+G R + + C+ CP K+
Sbjct: 914 WEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTG 973
Query: 588 REQQC 592
+C
Sbjct: 974 PWSEC 978
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 372 bits (955), Expect = e-103
Identities = 279/927 (30%), Positives = 419/927 (45%), Gaps = 127/927 (13%)
Query: 54 ALHLSAFGK--GFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRG-CFFSGTVNGEP 110
+LHL G F + L S +AP F ++ LG +G + CF+ G++
Sbjct: 96 SLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHR 155
Query: 111 ESLAAVSLCRGLSGSFLLDGEEFTIQP-------------QGAGGS------LAQPHRLQ 151
S A+S C+GLSG + ++ ++P QG+ S +PH
Sbjct: 156 NSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPH--- 212
Query: 152 RWGPAGARPLPRGPEWEV----------ETGEGQRQERGDHQEDSEEESQEEEAEGASEP 201
P + L WE+ G Q+Q ++ + +E+
Sbjct: 213 --APGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFIL--- 267
Query: 202 PPPLGATSRTKRFV-----SEARFVETLLVADASMAAFYGAD-LQNHILTLMSVAARIYK 255
P + R KR + +E VETL+V D M +G + + ++LT++++ + ++K
Sbjct: 268 PDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFK 327
Query: 256 HPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF-NQPSDRHPEHYDTA 314
+I +IN+ +V ++++EDE+ G +S + TL +FC WQ + RH D A
Sbjct: 328 DGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH----DHA 383
Query: 315 ILLTRQNFCGQEGL-CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPH 373
ILLT + C + CDTLG A I +C +SC++ ED GL A T+AHE GH M H
Sbjct: 384 ILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIH 443
Query: 374 D-DSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA 432
D + C + G ++M+P N WSPCS YL + L CL D P
Sbjct: 444 DGEGNMCKKSEG-----NIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPV 498
Query: 433 --LPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKN 490
P LPG LY + QC+ FG + C +D+C LWCH G + C TK
Sbjct: 499 KEYKYPEKLPGE--LYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK--CETK- 553
Query: 491 GSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSH 550
+P A+GT CG C G C+ + E PKP G W+ W W CSRTCGGGV
Sbjct: 554 -FMPAAEGTICGHDMWCRGGQCVKYGD-EGPKPT-HGHWSDWSSWSPCSRTCGGGVSHRS 610
Query: 551 RECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQW 610
R C +P+P +GG++C G + C++++CP D FR QC ++N+ + G +W
Sbjct: 611 RLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFR---GRHYKW 667
Query: 611 VPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVV 670
P Y V +D CKL+C A G F KV DGT C ++ +C+ G C + GCD+V+
Sbjct: 668 KP-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVL 726
Query: 671 DSPRKLDKCGVCGGKGNSCRKVSGSLTPTNY--GYNDIVTIPAGATNIDVKQRSHPGVQN 728
S D CGVC G ++C G T ++ Y +VTIP+GA +I + + +
Sbjct: 727 GSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYE-----MNV 781
Query: 729 DGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTV 788
+Y++++ A +Y LNG+ + + GT Y S E L + P E L V
Sbjct: 782 STSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIV 840
Query: 789 QLL---TVPGEVF-------------PPKVKYTFFVPN---------------------- 810
+LL PG + P + YT+ +
Sbjct: 841 ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL 900
Query: 811 --DVDFSMQSSKERATTNIIQPLLHA---QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ 865
V+ S + K R T ++ + A W +G+WS CS TCG G Q R V+C
Sbjct: 901 KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY 960
Query: 866 ASATCNKALKPEDA----KPCESQLCP 888
S +L P+ A + C SQ CP
Sbjct: 961 DSEPVPASLCPQPAPSSRQACNSQSCP 987
Score = 51.2 bits (121), Expect = 4e-06
Identities = 24/58 (41%), Positives = 31/58 (53%), Gaps = 6/58 (10%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECR--DPSGQA----SATCNKALKPEDAKPCESQLC 887
W G W+ECS TCG GW++R V C+ +PS +A A C KP + C Q C
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL 889
W WS+C+++CG G Q R+V+C G+ ++ C KP + C + CP+
Sbjct: 1130 WFASPWSQCTASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCPI 1182
Score = 41.2 bits (95), Expect = 0.004
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 533 GPWGECSRTCGGGVQFSHRECK-----DPEPQNGGRYCLGRRAKYQSCHTEECPP 582
G W CSRTCGGG Q +C D EP + Q+C+++ CPP
Sbjct: 934 GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP 988
Score = 40.0 bits (92), Expect = 0.010
Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 8/62 (12%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDP--SGQ----ASATCNKALKP--EDAKPCESQL 886
QW++ WS+CS TC G Q+R ++C + SG+ AS C+ KP E + C
Sbjct: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
Query: 887 CP 888
CP
Sbjct: 1114 CP 1115
Score = 36.2 bits (82), Expect = 0.14
Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 3/74 (4%)
Query: 527 GGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKS 586
G W PW +C+ +CGGGVQ +C G + + +C+T CP K
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEK- 1185
Query: 587 FREQQCEKYNAYNY 600
++ C+ Y + Y
Sbjct: 1186 -KDAFCKDYFHWCY 1198
Score = 35.4 bits (80), Expect = 0.24
Identities = 29/113 (25%), Positives = 40/113 (35%), Gaps = 20/113 (17%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQC 592
GPW ECS TCG G + CK P + C +E P ++ Q+C
Sbjct: 993 GPWAECSHTCGKGWRKRAVACKSTNPS-----ARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
Query: 593 EKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
K LQW+ VS +C + C + F K + G
Sbjct: 1048 HK----------PKKLQWL-----VSAWSQCSVTCERGTQKRFLKCAEKYVSG 1085
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 364 bits (935), Expect = e-100
Identities = 266/842 (31%), Positives = 391/842 (46%), Gaps = 83/842 (9%)
Query: 44 TRLPGSAGELALH--LSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCF 101
T PG G +L+ ++ FGK LRL P+ + P +E R + + C
Sbjct: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVE-WQEDFRELFRQPLRQECV 153
Query: 102 FSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPL 161
++G V G P + A+S C GL+G D +F I+P L
Sbjct: 154 YTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEP-----------------------L 190
Query: 162 PRGPEWEVETGEGQ---RQERGDHQEDSEEESQEEEAEGASEPP-------PPLGATSRT 211
RG + + +G R+E + + EA G + P LG T R
Sbjct: 191 ERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERK 250
Query: 212 KRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLMVVK 269
+R + +E LLV D S+ F+G + +QN++LTLM++ IY S+ IN+ +V+
Sbjct: 251 RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVR 310
Query: 270 VLIVEDEKWGPEVS-DNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGL 328
+++V + + N +L C W + H EH+D + LTRQ+F G G+
Sbjct: 311 LIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-GPSGM 369
Query: 329 CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGK 388
G A + +C P +SC++ ++G +A +AHE GHVL M HD +G
Sbjct: 370 ---QGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS 426
Query: 389 HHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPA-AALPLPTGLPGRMALYQ 447
VMAPL WS CS + L+ L DCLLD P A P P LPG Y
Sbjct: 427 --VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPG--INYS 480
Query: 448 LDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLC 507
+D+QCR FG ++ C + C QLWC C TK G P DGT C PG C
Sbjct: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKG--PPLDGTECAPGKWC 538
Query: 508 SEGSCL---PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
+G C+ PE+ + DGGW+ W +G CSR+CGGGV+ R C +P P GGR
Sbjct: 539 FKGHCIWKSPEQTYGQ-----DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRL 593
Query: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
CLG +YQ C++EECP + FR QQC K N+Y Y + WVP Y +C+
Sbjct: 594 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY-YVHQNAK-HSWVP-YEPDDDAQKCE 650
Query: 625 LFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCG 683
L C++ + V DGT C + ++C RG+CV GCD V S + DKCGVCG
Sbjct: 651 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 710
Query: 684 GKGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKT-ADG 740
G + CR V G+L G +V IPAGA +I ++ ++ + + +K G
Sbjct: 711 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE-----ALEKSPHRIVVKNQVTG 765
Query: 741 QYLLNGNLAISAIEQDILVKGTILKYSGSIA-TLERLQSFRPLPEPLTVQLLTVPGEVFP 799
++LN A + G L++ ++ E L++ PLPE + + L P E P
Sbjct: 766 SFILNPK-GKEATSRTFTAMG--LEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGP 821
Query: 800 -PKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVE 858
+ Y + + D+ + S+ +++ + +W L W+ CS CG G Q
Sbjct: 822 RSSLAYKYVIHEDLLPLIGSNNV-----LLEEMDTYEWALKSWAPCSKACGGGIQFTKYG 876
Query: 859 CR 860
CR
Sbjct: 877 CR 878
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
AQW LG WS+CS+TCG G Q+R V CR + + C + +P+ + C C
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHC-EGDRPDTVQVCSLPAC 1024
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/151 (24%), Positives = 53/151 (35%), Gaps = 23/151 (15%)
Query: 472 CAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAP 531
C +L T G + L NG+ C + CL P P A
Sbjct: 926 CGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL-----RVPCP------AQ 974
Query: 532 W--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRA-KYQSCHTEECPPDGKSFR 588
W G W +CS TCG G+Q C+ G +C G R Q C C +
Sbjct: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGGN----H 1028
Query: 589 EQQCEKYNAYNYTDMDGNLLQWVPKYAGVSP 619
+ + + + +G QWVP+ + P
Sbjct: 1029 QNSTVRADVWELGTPEG---QWVPQSEPLHP 1056
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 362 bits (928), Expect = 1e-99
Identities = 264/842 (31%), Positives = 388/842 (46%), Gaps = 86/842 (10%)
Query: 44 TRLPGSAGELALH--LSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCF 101
T PG G +L+ ++ FGK LRL P+ + P +E R + + C
Sbjct: 95 TLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVE-WQEDFRELFRQPLRQECV 153
Query: 102 FSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPL 161
++G V G P + A+S C GL+G D +F I+P L
Sbjct: 154 YTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEP-----------------------L 190
Query: 162 PRGPEWEVETGEGQ---RQERGDHQEDSEEESQEEEAEGASEPP-------PPLGATSRT 211
RG + + +G R+E + + EA G + P LG T R
Sbjct: 191 ERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERK 250
Query: 212 KRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLMVVK 269
+R + +E LLV D S+ F+G + +QN++LTLM++ IY S+ IN+ +V+
Sbjct: 251 RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVR 310
Query: 270 VLIVEDEKWGPEVS-DNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGL 328
+++V + + N +L C W + H EH+D + LTRQ+F
Sbjct: 311 LIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF------ 364
Query: 329 CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGK 388
G A + +C P +SC++ ++G +A +AHE GHVL M HD +G
Sbjct: 365 -GPSGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGS 423
Query: 389 HHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPA-AALPLPTGLPGRMALYQ 447
VMAPL WS CS + L+ L DCLLD P A P P LPG Y
Sbjct: 424 --VMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPG--INYS 477
Query: 448 LDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLC 507
+D+QCR FG ++ C + C QLWC C TK G P DGT C PG C
Sbjct: 478 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKG--PPLDGTECAPGKWC 535
Query: 508 SEGSCL---PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
+G C+ PE+ + DGGW+ W +G CSR+CGGGV+ R C +P P GGR
Sbjct: 536 FKGHCIWKSPEQTYGQ-----DGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRL 590
Query: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
CLG +YQ C++EECP + FR QQC K N+Y Y + WVP Y +C+
Sbjct: 591 CLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY-YVHQNAK-HSWVP-YEPDDDAQKCE 647
Query: 625 LFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCG 683
L C++ + V DGT C + ++C RG+CV GCD V S + DKCGVCG
Sbjct: 648 LICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCG 707
Query: 684 GKGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKT-ADG 740
G + CR V G+L G +V IPAGA +I ++ ++ + + +K G
Sbjct: 708 GDNSHCRTVKGTLGKASKQAGALKLVQIPAGARHIQIE-----ALEKSPHRIVVKNQVTG 762
Query: 741 QYLLNGNLAISAIEQDILVKGTILKYSGSIA-TLERLQSFRPLPEPLTVQLLTVPGEVFP 799
++LN A + G L++ ++ E L++ PLPE + + L P E P
Sbjct: 763 SFILNPK-GKEATSRTFTAMG--LEWEDAVEDAKESLKTSGPLPEAIAI-LALPPTEGGP 818
Query: 800 -PKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVE 858
+ Y + + D+ + S+ +++ + +W L W+ CS CG G Q
Sbjct: 819 RSSLAYKYVIHEDLLPLIGSNNV-----LLEEMDTYEWALKSWAPCSKACGGGIQFTKYG 873
Query: 859 CR 860
CR
Sbjct: 874 CR 875
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 2/54 (3%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
AQW LG WS+CS+TCG G Q+R V CR + + C + +P+ + C C
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVCR-TNANSLGHC-EGDRPDTVQVCSLPAC 1021
Score = 33.5 bits (75), Expect = 0.90
Identities = 37/151 (24%), Positives = 53/151 (35%), Gaps = 23/151 (15%)
Query: 472 CAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAP 531
C +L T G + L NG+ C + CL P P A
Sbjct: 923 CGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL-----RVPCP------AQ 971
Query: 532 W--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRA-KYQSCHTEECPPDGKSFR 588
W G W +CS TCG G+Q C+ G +C G R Q C C +
Sbjct: 972 WRLGAWSQCSATCGEGIQQRQVVCRTNANSLG--HCEGDRPDTVQVCSLPACGGN----H 1025
Query: 589 EQQCEKYNAYNYTDMDGNLLQWVPKYAGVSP 619
+ + + + +G QWVP+ + P
Sbjct: 1026 QNSTVRADVWELGTPEG---QWVPQSEPLHP 1053
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 345 bits (884), Expect = 1e-94
Identities = 271/907 (29%), Positives = 395/907 (43%), Gaps = 137/907 (15%)
Query: 3 PAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAFGK 62
P PAAP P R P P A P PG L LHL AFG+
Sbjct: 52 PLPAAPG------------PRRRRRPRTPPAA--------PRARPGERA-LLLHLPAFGR 90
Query: 63 GFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR-- 120
L+L D FL+ F++E G + R R CF+SG V G P SL ++S C
Sbjct: 91 DLYLQLRRDLRFLSRGFEVEEAGAARRRG---RPAELCFYSGRVLGHPGSLVSLSACGAA 147
Query: 121 -GLSGSFLLDGEEFTIQP--QGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQ 177
GL G L E+ IQP G + H ++R +W +
Sbjct: 148 GGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLIRR-------------KWSLTPSPSAEA 194
Query: 178 ERGDHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGA 237
+R E + E++ P R SE VETL+VADA M ++GA
Sbjct: 195 QR---PEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSE-HTVETLVVADADMVQYHGA 250
Query: 238 DL-QNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNW 296
+ Q ILT+M++ +++H S+ IN+ V K++++ + +G +L +FC+W
Sbjct: 251 EAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHW 310
Query: 297 QRRF---------NQ-PSDRH-PEHYDTAILLTRQNFC-GQEGLCDTLGVADIGTICDPN 344
Q NQ P + P D A+ +TR +FC ++ CDT+G+A +G +C
Sbjct: 311 QNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAK 370
Query: 345 KSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT-- 402
+ C + ED GL A T+AHELGH L M HDD G+ H+M+ +V
Sbjct: 371 RKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCA-----GRSHIMSGEWVKGRNPSD 425
Query: 403 LPWSPCSAMYLTELLDGGHGDCLLDAPAAA---LPLPTGLPGRMALYQLDQQCRQIFGPD 459
L WS CS L L CLL + + LP LPG Y ++QC+ +FG +
Sbjct: 426 LSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMH--YSANEQCQILFGMN 483
Query: 460 FRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVE 519
C N +CA LWC +G + C TK P DGT CG C G C+ + +
Sbjct: 484 ATFCRNMEHL-MCAGLWCLVEG-DTSCKTKLD--PPLDGTECGADKWCRAGECVSKTPI- 538
Query: 520 RPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEE 579
P+ V DG W+PWG W CSRTCG G +F R+C +P P GG +C G ++ C
Sbjct: 539 -PEHV-DGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLP 596
Query: 580 CPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAG-----VSPRDRCKLFCRARGRSE 634
CP SFR+QQC+ ++ + PK G V C+L+C G+
Sbjct: 597 CPKGLPSFRDQQCQAHDRLS------------PKKKGLLTAVVVDDKPCELYCSPLGKES 644
Query: 635 FKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG 694
+ +V+DGT CGP +CV G+C K GCD ++ S K D+CGVC G G +C V G
Sbjct: 645 PLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKG 704
Query: 695 SLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIE 754
SH ALK + G+ +N + I +
Sbjct: 705 DF-------------------------SH------ARGTALKDS-GKGSINSDWKIE-LP 731
Query: 755 QDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDF 814
+ + GT ++Y E++ + P PL + +L + + + Y + VP +
Sbjct: 732 GEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHLMVLLFHDQDY--GIHYEYTVPVNRTA 788
Query: 815 SMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKAL 874
QS E+ ++ W W CS CG G +R V C + + N +
Sbjct: 789 ENQSEPEKPQDSLF------IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD 842
Query: 875 KPEDAKP 881
P+ ++P
Sbjct: 843 CPQASRP 849
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQASATCNKALKPEDAKPCESQLC 887
+W GDWS CSSTCG G Q R V+C +G+ + C KP + C ++C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 43.5 bits (101), Expect = 9e-04
Identities = 17/48 (35%), Positives = 28/48 (58%), Gaps = 4/48 (8%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCE 883
W +WS+CS++CG G +RTV C + G+ C+ + +P + CE
Sbjct: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACE 968
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/91 (29%), Positives = 36/91 (39%), Gaps = 5/91 (5%)
Query: 802 VKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD 861
V T + ND D S E ++WV G WS CS+TC G+Q R V C
Sbjct: 831 VNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVY 890
Query: 862 PSGQASATCNKAL-----KPEDAKPCESQLC 887
+ + L +P + CE Q C
Sbjct: 891 QLQNGTHVATRPLYCPGPRPAAVQSCEGQDC 921
Score = 40.8 bits (94), Expect = 0.006
Identities = 34/129 (26%), Positives = 47/129 (36%), Gaps = 12/129 (9%)
Query: 457 GPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEE 516
GP + QD C +W ++ ++ C G W C S+G C
Sbjct: 907 GPRPAAVQSCEGQD-CLSIWEASEWSQ--CSASCGKGVWKRTVACTN----SQGKCDAST 959
Query: 517 EVERPKPVAD-GGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC--LGRRAK 571
+ D G W G W CS TCG G+Q +C G C L + A
Sbjct: 960 RPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAP 1019
Query: 572 YQSCHTEEC 580
Y+ C+ E C
Sbjct: 1020 YRQCYQEVC 1028
Score = 36.6 bits (83), Expect = 0.11
Identities = 26/68 (38%), Positives = 31/68 (45%), Gaps = 10/68 (14%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDP-EPQNGGR------YCLG-RRAKYQSCHTEECPPDG 584
GPW CS TC G F HRE + QNG YC G R A QSC ++C
Sbjct: 868 GPWSPCSATCEKG--FQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIW 925
Query: 585 KSFREQQC 592
++ QC
Sbjct: 926 EASEWSQC 933
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
Length = 1207
Score = 343 bits (879), Expect = 5e-94
Identities = 271/911 (29%), Positives = 415/911 (45%), Gaps = 112/911 (12%)
Query: 23 LARGAPA--RPAAGGQASELVVPTRLPGSAG-ELALHLSAFGKGFVLRLAPDDSFLAPEF 79
L+ GAPA +P Q P + G E+ L + AF + L L D FLAP F
Sbjct: 132 LSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRF 191
Query: 80 KIERLGGSGRATGGERGL--------RGCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGE 131
+E+ G G GCF++G V P SLA+ S C G F+ E
Sbjct: 192 AVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNE 251
Query: 132 EFT-IQPQGAGGSLA-QPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEE 189
+F I+P ++ PHR+ R Q+R ++ +E+
Sbjct: 252 DFIFIEPLNDTMAITGHPHRVYR------------------------QKRSMEEKVTEKS 287
Query: 190 SQEEEAEGA-SEPPPP----LGATSRTKRF---VSEARFVETLLVADASMAAFYGADL-Q 240
+ G S+ P + + R KR+ + + +ET++VAD +M +++GAD +
Sbjct: 288 ALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAAR 347
Query: 241 NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRR- 299
ILT++++ +++H S+ +NL V+K++++ + + +G L +FC WQ
Sbjct: 348 RFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEE 407
Query: 300 FNQPSDRHPE----------HYDTAILLTRQNFC-GQEGLCDTLGVADIGTICDPNKSCS 348
F + +D H E D AIL+TR++FC ++ CDT+G+A + +C + C
Sbjct: 408 FGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCI 467
Query: 349 VIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT--LPWS 406
+ ED GL A T+AHE+GH + + HD+ P H+M+ ++ + WS
Sbjct: 468 IAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA-----DGLHIMSGEWIKGQNLGDVSWS 522
Query: 407 PCSAMYLTELLDGGHGDCLLDA---PAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHC 463
CS L L +CLL ++ +P+ LPG Y D+QC+ +FGP C
Sbjct: 523 RCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMT--YTADEQCQILFGPLASFC 580
Query: 464 PNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKP 523
+C LWC +G E C TK P DGT C G C G C P+
Sbjct: 581 QEMQ-HVICTGLWCKVEG-EKECRTKLD--PPMDGTDCDLGKWCKAGECT--SRTSAPEH 634
Query: 524 VADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583
+A G W+ W P CSRTC G+ R+C P + R C G R +Y+ C CP
Sbjct: 635 LA-GEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAG 688
Query: 584 GKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVI 643
FR+ QC+ Y+ T ++LQW A + C LFC G+ + + KV+
Sbjct: 689 LPGFRDWQCQAYSVR--TSSPKHILQW---QAVLDEEKPCALFCSPVGKEQPILLSEKVM 743
Query: 644 DGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT-NYG 702
DGT CG + L IC G+C K GCD ++ S + D CGVC G G SC+ + G T G
Sbjct: 744 DGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAG 803
Query: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
Y +++ IPAGA I V + + +YLAL+ A G+ +N + I + GT
Sbjct: 804 YVEVLVIPAGARRIKVVEE-----KPAHSYLALRDA-GKQSINSDWKIEH-SGAFNLAGT 856
Query: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
+ Y E++ + P PL + +L + + +YT +P+D QSSK
Sbjct: 857 TVHYVRR-GLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYT--IPSDPLPENQSSKAP 913
Query: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC-----RDPSGQASATCNKALKPE 877
+PL W W +C +TCG G ++ TV C ++ S + C KPE
Sbjct: 914 ------EPLF--MWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPE 965
Query: 878 -DAKPCESQLC 887
+ C Q C
Sbjct: 966 PQIRKCNEQPC 976
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDP-SGQASATCNKALKPEDAKPCESQLC 887
W +GDWS+CS TCG G Q R ++C +G+ C + KP +PC Q C
Sbjct: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 45.1 bits (105), Expect = 3e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 4/48 (8%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCE 883
W G WSECS CG G + RTV C +P + C + +P +A+ CE
Sbjct: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK----CVLSTRPREAEDCE 1083
Score = 37.0 bits (84), Expect = 0.081
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLG--RRAKYQSCHTEEC 580
G W +CS TCG G+Q +C G C + A Y+ CH + C
Sbjct: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 31.6 bits (70), Expect = 3.4
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 8/53 (15%)
Query: 535 WGECSRTCGGGVQFSHRECKDPEPQNG------GRYCLG-RRAKYQSCHTEEC 580
W CSRTCG G+Q C + NG R C+G + A Q C ++C
Sbjct: 985 WTPCSRTCGKGMQSRQVACTQ-QLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 288 bits (737), Expect = 2e-77
Identities = 215/761 (28%), Positives = 320/761 (42%), Gaps = 88/761 (11%)
Query: 201 PPPP--LGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
PP P R +R +E L+ + + D + ++LT +++ A + + PS
Sbjct: 60 PPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS 119
Query: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
+ + +VK++I+ + + P ++ N +L + C W + N D P H D + +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
R + +G GV +G C P SC + ED G T+AHE+GH + HD +
Sbjct: 180 RFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG 239
Query: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLD----APAAALP 434
GP G HVMA L WSPCS L LL G C+ D P +A
Sbjct: 240 SG--CGPSG--HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGH 295
Query: 435 LPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL 493
P PG Y ++QCR FGP C D+C L CHTD PL + L
Sbjct: 296 PPDAQPG--LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTD---PLDQSSCSRL 350
Query: 494 --PWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHR 551
P DGT CG CS+G C E+ P G W+ WGP CSR+CGGGV R
Sbjct: 351 LVPLLDGTECGVEKWCSKGRCRSLVEL-TPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRR 409
Query: 552 ECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQ 609
+C +P P GGR C+G + + C+T+ C F QQC + + G +
Sbjct: 410 QCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYH 469
Query: 610 WVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE------TLAICVRGQCVK 663
W C+ CRA G S +DGT C P TL++CV G C
Sbjct: 470 WGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Query: 664 AGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN-YGYNDIVTIPAGATNIDVKQR- 721
GCD +DS + D+C VCGG ++C GS T Y +T+ T++ +
Sbjct: 530 FGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHR 589
Query: 722 ---SHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQS 778
+H V+ G Y+ G+ ++ N ++ +D V+ + + LE ++
Sbjct: 590 PLFTHLAVRIGGRYVVA----GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRI 645
Query: 779 FRPLPEPLTVQLLTVPGEVF----PPKVKYTFFVPND----------------------- 811
+ PL E +Q+ GE + P + +T+F P
Sbjct: 646 WGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRW 705
Query: 812 VDFSM--QSSKERATT---------------NIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
V++S Q+ KE T +++P W +GD+ CS++CG G +
Sbjct: 706 VNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP-CPPYWAVGDFGPCSASCGGGLRE 764
Query: 855 RTVECRDPSGQ-----ASATCNK-ALKPEDA-KPCESQLCP 888
R V C + G A C A +P A + C Q CP
Sbjct: 765 RPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT---CNKALKPEDAKPCESQLC 887
+W +G W ECS +CG G QRR C P QA C KP + C + C
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 33.5 bits (75), Expect = 0.90
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQ----ASATCNKALKPEDAKPC 882
+W + CS++CG G RR+V C + GQ A C ++PE + PC
Sbjct: 1015 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1067
Score = 31.6 bits (70), Expect = 3.4
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 509 EGSC--LPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQ 559
E +C L E P +AD + W G W ECS +CG G+Q C P+ Q
Sbjct: 1052 EAACAALVRPEASVPCLIADCTYR-WHVGTWMECSVSCGDGIQRRRDTCLGPQAQ 1105
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 288 bits (737), Expect = 2e-77
Identities = 215/761 (28%), Positives = 320/761 (42%), Gaps = 88/761 (11%)
Query: 201 PPPP--LGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
PP P R +R +E L+ + + D + ++LT +++ A + + PS
Sbjct: 60 PPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS 119
Query: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
+ + +VK++I+ + + P ++ N +L + C W + N D P H D + +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
R + +G GV +G C P SC + ED G T+AHE+GH + HD +
Sbjct: 180 RFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG 239
Query: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLD----APAAALP 434
GP G HVMA L WSPCS L LL G C+ D P +A
Sbjct: 240 SG--CGPSG--HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGH 295
Query: 435 LPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL 493
P PG Y ++QCR FGP C D+C L CHTD PL + L
Sbjct: 296 PPDAQPG--LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTD---PLDQSSCSRL 350
Query: 494 --PWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHR 551
P DGT CG CS+G C E+ P G W+ WGP CSR+CGGGV R
Sbjct: 351 LVPLLDGTECGVEKWCSKGRCRSLVEL-TPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRR 409
Query: 552 ECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQ 609
+C +P P GGR C+G + + C+T+ C F QQC + + G +
Sbjct: 410 QCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYH 469
Query: 610 WVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE------TLAICVRGQCVK 663
W C+ CRA G S +DGT C P TL++CV G C
Sbjct: 470 WGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 529
Query: 664 AGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN-YGYNDIVTIPAGATNIDVKQR- 721
GCD +DS + D+C VCGG ++C GS T Y +T+ T++ +
Sbjct: 530 FGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHR 589
Query: 722 ---SHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQS 778
+H V+ G Y+ G+ ++ N ++ +D V+ + + LE ++
Sbjct: 590 PLFTHLAVRIGGRYVVA----GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRI 645
Query: 779 FRPLPEPLTVQLLTVPGEVF----PPKVKYTFFVPND----------------------- 811
+ PL E +Q+ GE + P + +T+F P
Sbjct: 646 WGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRW 705
Query: 812 VDFSM--QSSKERATT---------------NIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
V++S Q+ KE T +++P W +GD+ CS++CG G +
Sbjct: 706 VNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP-CPPYWAVGDFGPCSASCGGGLRE 764
Query: 855 RTVECRDPSGQ-----ASATCNK-ALKPEDA-KPCESQLCP 888
R V C + G A C A +P A + C Q CP
Sbjct: 765 RPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT---CNKALKPEDAKPCESQLC 887
+W +G W ECS +CG G QRR C P QA C KP + C + C
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 33.5 bits (75), Expect = 0.90
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQ----ASATCNKALKPEDAKPC 882
+W + CS++CG G RR+V C + GQ A C ++PE + PC
Sbjct: 1015 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1067
Score = 31.6 bits (70), Expect = 3.4
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 509 EGSC--LPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQ 559
E +C L E P +AD + W G W ECS +CG G+Q C P+ Q
Sbjct: 1052 EAACAALVRPEASVPCLIADCTYR-WHVGTWMECSVSCGDGIQRRRDTCLGPQAQ 1105
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 268 bits (684), Expect = 2e-71
Identities = 206/757 (27%), Positives = 309/757 (40%), Gaps = 111/757 (14%)
Query: 201 PPPP--LGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
PP P R +R +E L+ + + D + ++LT +++ A + + PS
Sbjct: 60 PPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS 119
Query: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
+ + +VK++I+ + + P ++ N +L + C W + N D P H D + +T
Sbjct: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
Query: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
R + +G GV +G C P SC + ED G T+AHE+GH + HD +
Sbjct: 180 RFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG 239
Query: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTG 438
GP G HVMA L WSPCS L LL
Sbjct: 240 SG--CGPSG--HVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------- 276
Query: 439 LPGRMALYQLDQQCRQIFGPDFRHCPNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL--PW 495
++QCR FGP C D+C L CHTD PL + L P
Sbjct: 277 ----------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTD---PLDQSSCSRLLVPL 323
Query: 496 ADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKD 555
DGT CG CS+G C E+ P G W+ WGP CSR+CGGGV R+C +
Sbjct: 324 LDGTECGVEKWCSKGRCRSLVELT-PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN 382
Query: 556 PEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPK 613
P P GGR C+G + + C+T+ C F QQC + + G + W
Sbjct: 383 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA 442
Query: 614 YAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE------TLAICVRGQCVKAGCD 667
C+ CRA G S +DGT C P TL++CV G C GCD
Sbjct: 443 VPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCD 502
Query: 668 HVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN-YGYNDIVTIPAGATNIDVKQR----S 722
+DS + D+C VCGG ++C GS T Y +T+ T++ + +
Sbjct: 503 GRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFT 562
Query: 723 HPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPL 782
H V+ G Y+ G+ ++ N ++ +D V+ + + LE ++ + PL
Sbjct: 563 HLAVRIGGRYVVA----GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPL 618
Query: 783 PEPLTVQLLTVPGEVF----PPKVKYTFFVPND-----------------------VDFS 815
E +Q+ GE + P + +T+F P V++S
Sbjct: 619 QEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYS 678
Query: 816 M--QSSKERATT---------------NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVE 858
Q+ KE T +++P W +GD+ CS++CG G + R V
Sbjct: 679 CLDQARKELVETVQCQGSQQPPAWPEACVLEP-CPPYWAVGDFGPCSASCGGGLRERPVR 737
Query: 859 CRDPSGQ-----ASATCNK-ALKPEDA-KPCESQLCP 888
C + G A C A +P A + C Q CP
Sbjct: 738 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT---CNKALKPEDAKPCESQLC 887
+W +G W ECS +CG G QRR C P QA C KP + C + C
Sbjct: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 33.5 bits (75), Expect = 0.90
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQ----ASATCNKALKPEDAKPC 882
+W + CS++CG G RR+V C + GQ A C ++PE + PC
Sbjct: 984 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1036
Score = 31.6 bits (70), Expect = 3.4
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 509 EGSC--LPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQ 559
E +C L E P +AD + W G W ECS +CG G+Q C P+ Q
Sbjct: 1021 EAACAALVRPEASVPCLIADCTYR-WHVGTWMECSVSCGDGIQRRRDTCLGPQAQ 1074
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 188 bits (477), Expect = 2e-47
Identities = 115/365 (31%), Positives = 164/365 (44%), Gaps = 64/365 (17%)
Query: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFR 588
W PW W CSRTCGGGV F R C + ++GG C+G ++SC TE CP + FR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 589 EQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLC 648
+QC +++ + G +W+P Y S ++C+L C +G + + V+DGT C
Sbjct: 88 AEQCAEFDG---AEFQGRRYRWLPYY---SAPNKCELNCIPKGENFYYKHREAVVDGTPC 141
Query: 649 GPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVT 708
P +CV G C GCDH +DS ++ DKC CGG G +C V+G+ + ND+
Sbjct: 142 EPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGT-----FDANDLSR 196
Query: 709 IPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYS- 767
A+K G+Y LNG+ I A + TIL Y
Sbjct: 197 -------------------------AVKNVRGEYYLNGHWTIEAARA-LPAASTILHYER 230
Query: 768 ---GSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERAT 824
G +A ERL + P EPL ++L++ P V Y + +P
Sbjct: 231 GAEGDLAP-ERLHARGPTSEPLVIELISQEPN---PGVHYEYHLP--------------- 271
Query: 825 TNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECR-DPSGQASATCNKALKPEDAKPCE 883
+ +P W G WS+CS+ CG G Q R V C D C + +P D + C
Sbjct: 272 --LRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCN 329
Query: 884 SQLCP 888
CP
Sbjct: 330 LHPCP 334
Score = 47.4 bits (111), Expect = 6e-05
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 2/58 (3%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCPL 889
A W W ECS +CG G ++R+V CR G +A C+ +P +PC + CPL
Sbjct: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPL 455
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/63 (41%), Positives = 33/63 (52%), Gaps = 6/63 (9%)
Query: 830 PLLHAQ-WVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNKALKPEDAKPCESQL 886
PLL Q W +G W CS +C +G +RR V C PS S + KP D +PC +Q
Sbjct: 454 PLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL---QHSKPVDVEPCNTQP 510
Query: 887 CPL 889
C L
Sbjct: 511 CHL 513
Score = 33.1 bits (74), Expect = 1.2
Identities = 45/188 (23%), Positives = 65/188 (34%), Gaps = 30/188 (15%)
Query: 404 PWSPCSA----------MYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCR 453
PW+PCSA +Y G + + +A A LP G P + L Q+C
Sbjct: 343 PWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLP---GKPPAIQACNL-QRCA 398
Query: 454 QIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCL 513
+ C + V + L HT SL D P L
Sbjct: 399 AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLE--DRPP------------L 444
Query: 514 PEEEVERPKPV-ADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKY 572
E V P+ +D W G WG CS++C G + C P + G +
Sbjct: 445 TEPCVHEDCPLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDV 503
Query: 573 QSCHTEEC 580
+ C+T+ C
Sbjct: 504 EPCNTQPC 511
Score = 32.7 bits (73), Expect = 1.5
Identities = 21/54 (38%), Positives = 27/54 (50%), Gaps = 10/54 (18%)
Query: 529 WAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPP 582
W+P PWGECS +CG GV+ C+ G R L A +C E+ PP
Sbjct: 400 WSP-EPWGECSVSCGVGVRKRSVTCR------GERGSLLHTA---ACSLEDRPP 443
Score = 30.0 bits (66), Expect = 10.0
Identities = 23/70 (32%), Positives = 32/70 (45%), Gaps = 11/70 (15%)
Query: 450 QQCRQIFGPDF-----RHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPG 504
+QC + G +F R P SA + C +L C G + + DGTPC PG
Sbjct: 89 EQCAEFDGAEFQGRRYRWLPYYSAPNKC-ELNCIPKGENFYYKHREAVV---DGTPCEPG 144
Query: 505 --HLCSEGSC 512
+C +GSC
Sbjct: 145 KRDVCVDGSC 154
Score = 30.0 bits (66), Expect = 10.0
Identities = 10/15 (66%), Positives = 11/15 (73%)
Query: 533 GPWGECSRTCGGGVQ 547
GPW CS +CGGG Q
Sbjct: 342 GPWAPCSASCGGGSQ 356
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 184 bits (466), Expect = 4e-46
Identities = 159/500 (31%), Positives = 228/500 (45%), Gaps = 65/500 (13%)
Query: 25 RGAPARPAA--GGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE 82
R AP R + GG E PGS L +++ FG+ LRL P+ +AP +E
Sbjct: 88 RAAPVRTPSFPGGNEEE-------PGS--HLFYNVTVFGRDLHLRLRPNARLVAPGATME 138
Query: 83 RLGGSGRATGGERGLRGCFFSGTVNGEPE-SLAAVSLCRGLSGSFLLDGEEFTIQP--QG 139
G G T E L C + G V G E S A+S C GL+G ++ EEF I+P +G
Sbjct: 139 WQGEKG-TTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKG 197
Query: 140 AGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQ-----EEE 194
A+ R+ + R P G Q + G + + S+ EE
Sbjct: 198 LAAQEAEQGRVH--------VVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEH 249
Query: 195 AEGASEPPPPLGATSRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAAR 252
A + R +R ++ + +E LL D S+ F+G + +Q ++LTLM++
Sbjct: 250 ANSSRR---------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
Query: 253 IYKHPSIKNSINLMVVKVLIVEDEKWGPEVS----DNGGLTLRNFCNWQRRFNQPSDRHP 308
IY S+ IN+++V+++++ +G +S N +L N C W +P H
Sbjct: 301 IYHDESLGAHINVVLVRIILLS---YGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHD 357
Query: 309 EHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHV 368
E++D AI LTRQ+F G G+ G A + +C P +SC++ ++G +A +AHE GHV
Sbjct: 358 EYHDHAIFLTRQDF-GPSGM---QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHV 413
Query: 369 LSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDA 428
L M HD R + +MAPL WS CS L+ L DCLLD
Sbjct: 414 LGMEHDGQG--NRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDD 469
Query: 429 PAA----ALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEP 484
P A ALP GL Y +++QCR FG + C D C QLWC
Sbjct: 470 PFAHDWPALPQLPGLH-----YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY 524
Query: 485 LCHTKNGSLPWADGTPCGPG 504
C TK G P DGT C PG
Sbjct: 525 FCKTKKG--PPLDGTMCAPG 542
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 177 bits (449), Expect = 4e-44
Identities = 110/342 (32%), Positives = 162/342 (47%), Gaps = 54/342 (15%)
Query: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
DG W WG W +CSRTCGGG +S R C GR C G+ +Y++C +CPPD +
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
Query: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
FR QQC YN Y G+ +W+P+Y P C L C A+G++ KV+DG
Sbjct: 129 DFRAQQCSAYNDVQY---QGHYYEWLPRYN--DPAAPCALKCHAQGQNLVVELAPKVLDG 183
Query: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGS----LTPTNY 701
T C ++L +C+ G C GCD + S K D CGVC G G++CR V G ++P
Sbjct: 184 TRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKR 243
Query: 702 GYNDIVTIPAG--ATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILV 759
N ++ +P G + I VK +H +++ L+ + G++ N LV
Sbjct: 244 EEN-VIAVPLGSRSVRITVKGPAHLFIESK----TLQGSKGEHSFNS-------PGVFLV 291
Query: 760 KGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSS 819
+ T +++ Q+F+ +P PL + K +YT + V F
Sbjct: 292 ENTTVEFQRG----SERQTFK-IPGPLMADFIF--------KTRYTAAKDSVVQFF---- 334
Query: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD 861
QP+ H QW D+ C+ TCG G+Q + EC D
Sbjct: 335 -------FYQPISH-QWRQTDFFPCTVTCGGGYQLNSAECVD 368
Score = 41.6 bits (96), Expect = 0.003
Identities = 17/48 (35%), Positives = 26/48 (54%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
+W+ +WS+C+ TCG G + R V C + G+ CN LK + C
Sbjct: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEEC 528
Score = 41.6 bits (96), Expect = 0.003
Identities = 39/128 (30%), Positives = 48/128 (37%), Gaps = 26/128 (20%)
Query: 477 CHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCL-------PEEEVERPKPVA---- 525
C+T+ P H GS T CG G + CL P EE KP A
Sbjct: 698 CNTEPCPPRWHV--GSWGPCSAT-CGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQAC 754
Query: 526 -----DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQN-----GGRYCLGRRA-KYQS 574
GW W +CSRTCGGG Q C+ C G +A ++S
Sbjct: 755 NQFDCPPGWHI-EEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKS 813
Query: 575 CHTEECPP 582
C +CPP
Sbjct: 814 CARTDCPP 821
Score = 40.8 bits (94), Expect = 0.006
Identities = 21/56 (37%), Positives = 27/56 (48%), Gaps = 3/56 (5%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKAL--KPEDAKPCESQLCP 888
+W +G W CS+TCG G Q R V C P G+ A + KP + C CP
Sbjct: 706 RWHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRDEKPHALQACNQFDCP 760
Score = 40.4 bits (93), Expect = 0.007
Identities = 20/60 (33%), Positives = 28/60 (46%), Gaps = 6/60 (10%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNKALKPED----AKPCESQLC 887
A+W WS+CS +CG G+ R V C+ +G +A P+D KPC C
Sbjct: 1485 ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Score = 39.3 bits (90), Expect = 0.016
Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 2/64 (3%)
Query: 533 GPWGECSRTCGGGVQFSHRECKDP-EPQNGGRYCLGRRAK-YQSCHTEECPPDGKSFREQ 590
G WG CS TCG G+Q C P E C + Q+C+ +CPP Q
Sbjct: 710 GSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ 769
Query: 591 QCEK 594
QC +
Sbjct: 770 QCSR 773
Score = 37.4 bits (85), Expect = 0.062
Identities = 13/25 (52%), Positives = 16/25 (64%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECR 860
W + +W +CS TCG G Q R V CR
Sbjct: 763 WHIEEWQQCSRTCGGGTQNRRVTCR 787
Score = 37.4 bits (85), Expect = 0.062
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 836 WVLGDWSECSSTCG-AGWQRRTVECRDPSGQ--ASATCNKALKP-EDAKPCESQLCP 888
W G+WS CS+TCG G + + +C +GQ + A C+ KP +PC + CP
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
Score = 37.0 bits (84), Expect = 0.081
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKALKPEDAKPCESQLC 887
W G W C++ CG G+Q R V+C R A C + KP + C C
Sbjct: 1601 WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 35.0 bits (79), Expect = 0.31
Identities = 13/23 (56%), Positives = 17/23 (73%)
Query: 838 LGDWSECSSTCGAGWQRRTVECR 860
+GDWS+CS +CG G QRR C+
Sbjct: 825 VGDWSKCSVSCGVGIQRRKQVCQ 847
Score = 33.5 bits (75), Expect = 0.90
Identities = 13/20 (65%), Positives = 15/20 (75%)
Query: 841 WSECSSTCGAGWQRRTVECR 860
WS CS+TCG G Q R V+CR
Sbjct: 573 WSACSTTCGPGVQVREVKCR 592
Score = 31.2 bits (69), Expect = 4.5
Identities = 11/21 (52%), Positives = 13/21 (61%)
Query: 534 PWGECSRTCGGGVQFSHRECK 554
PW CS TCG GVQ +C+
Sbjct: 572 PWSACSTTCGPGVQVREVKCR 592
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 177 bits (449), Expect = 4e-44
Identities = 119/373 (31%), Positives = 167/373 (44%), Gaps = 55/373 (14%)
Query: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
DG W WGPW ECSRTCGGG +S R C + C GR +Y++C +CPP+
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
FR QQC +A+N G +W+P P + C L C+A+G + KV+DG
Sbjct: 87 DFRAQQC---SAHNDVKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG---SLTPTNYG 702
T C E+L +C+ G C GCDH + S K D CGVC G G++CR V G S
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
+ +V IP G+ +I L LK D YL L + E + GT
Sbjct: 202 DDTVVAIPYGSRHI---------------RLVLKGPDHLYLETKTLQGTKGENSLSSTGT 246
Query: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
L + S+ F+ P+ +++ F K++ + + V F
Sbjct: 247 FLVDNSSV-------DFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI------- 292
Query: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPEDAKP 881
QP++H +W D+ CS+TCG G+Q + EC D S + A PE+ KP
Sbjct: 293 ----FYQPIIH-RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKP 347
Query: 882 ------CESQLCP 888
C CP
Sbjct: 348 KPKLQECNLDPCP 360
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 11/55 (20%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
++W+L DW+ECS++CG G Q R SA C K LK + S LCP
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTR-----------SAICRKMLKTGLSTVVNSTLCP 833
Score = 42.7 bits (99), Expect = 0.001
Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 7/61 (11%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECR--DPSGQASATCNK-----ALKPEDAKPCESQL 886
++W++ WS C+ +CG G Q R V C+ SG ++ N A +P D + C QL
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 887 C 887
C
Sbjct: 1607 C 1607
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/48 (35%), Positives = 25/48 (52%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
+W+ +WS C+ TCG G + R V C D G + C+ KP + C
Sbjct: 439 KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
Score = 39.7 bits (91), Expect = 0.013
Identities = 22/63 (34%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--------ASATCNKALKPEDAKPCESQ 885
A+W +G WS CS TCG G Q R V C + A C + KP + C
Sbjct: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRF 726
Query: 886 LCP 888
CP
Sbjct: 727 NCP 729
Score = 39.3 bits (90), Expect = 0.016
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 6/60 (10%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
+W W+ CSS+CG G Q R V C + Q T C K A+PC CP
Sbjct: 379 RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 39.3 bits (90), Expect = 0.016
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 5/58 (8%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQAS-----ATCNKALKPEDAKPCESQLCP 888
W W CS TCG G Q+R V C+ S T A KP + C+ CP
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCP 789
Score = 37.4 bits (85), Expect = 0.062
Identities = 27/91 (29%), Positives = 36/91 (39%), Gaps = 16/91 (17%)
Query: 508 SEGSCLPEEEVERPKPVA---------DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEP 558
+E L +E +PKP W P W CSRTCGGGVQ CK
Sbjct: 702 NETVILADELCRQPKPSTVQACNRFNCPPAWYP-AQWQPCSRTCGGGVQKREVLCKQRMA 760
Query: 559 QNG-----GRYC-LGRRAKYQSCHTEECPPD 583
+C + A Q+C ++CP +
Sbjct: 761 DGSFLELPETFCSASKPACQQACKKDDCPSE 791
Score = 34.3 bits (77), Expect = 0.53
Identities = 22/84 (26%), Positives = 30/84 (35%), Gaps = 5/84 (5%)
Query: 809 PNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTC---GAGWQRRTVEC--RDPS 863
P D Q +K T L +W W +C+ C Q R V C RD
Sbjct: 1583 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI 1642
Query: 864 GQASATCNKALKPEDAKPCESQLC 887
S C+ +P + C S+ C
Sbjct: 1643 TLPSEQCSALPRPVSTQNCWSEAC 1666
Score = 32.3 bits (72), Expect = 2.0
Identities = 21/74 (28%), Positives = 31/74 (41%), Gaps = 9/74 (12%)
Query: 823 ATTNIIQPLLHAQWVLGDWSECSSTCG-AGWQRRTVEC---RDPSGQASATCNKALKPE- 877
+T N W + W+ C++TCG G+Q R VEC R C+ +P
Sbjct: 1657 STQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPAN 1716
Query: 878 ----DAKPCESQLC 887
+ PCE+ C
Sbjct: 1717 WQRCNITPCENMEC 1730
Score = 30.8 bits (68), Expect = 5.8
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKY-------QSCHTEECP 581
PW CS +CGGG+Q C + + Q + Y Q C+ +CP
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 30.8 bits (68), Expect = 5.8
Identities = 16/58 (27%), Positives = 26/58 (44%), Gaps = 6/58 (10%)
Query: 836 WVLGDWSECSSTCGAGWQRRTVEC-----RDPSGQASATCNKALKPEDAKPCESQLCP 888
W +++CS +CG G Q V C R+P+ + ++ P+ K C CP
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR-PPQLLKSCNLDPCP 667
Score = 30.4 bits (67), Expect = 7.6
Identities = 15/48 (31%), Positives = 23/48 (47%), Gaps = 1/48 (2%)
Query: 841 WSECSSTCGAGWQRRTVECRDPSGQASATCNKAL-KPEDAKPCESQLC 887
WS C+ TCG G Q R V C+ + + + + + E KP + C
Sbjct: 531 WSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRAC 578
Score = 30.4 bits (67), Expect = 7.6
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 11/53 (20%)
Query: 537 ECSRTCGGGVQFS-----HRECKDPEPQNGGRYCLGRRAKYQ---SCHTEECP 581
+CS +CGGGVQ + +++ ++P +N C+ R Q SC+ + CP
Sbjct: 618 KCSESCGGGVQEAVVSCLNKQTREPAEEN---LCVTSRRPPQLLKSCNLDPCP 667
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 177 bits (449), Expect = 4e-44
Identities = 119/373 (31%), Positives = 167/373 (44%), Gaps = 55/373 (14%)
Query: 526 DGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
DG W WGPW ECSRTCGGG +S R C + C GR +Y++C +CPP+
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 586 SFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDG 645
FR QQC +A+N G +W+P P + C L C+A+G + KV+DG
Sbjct: 87 DFRAQQC---SAHNDVKHHGQFYEWLP--VSNDPDNPCSLKCQAKGTTLVVELAPKVLDG 141
Query: 646 TLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSG---SLTPTNYG 702
T C E+L +C+ G C GCDH + S K D CGVC G G++CR V G S
Sbjct: 142 TRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKS 201
Query: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
+ +V IP G+ +I L LK D YL L + E + GT
Sbjct: 202 DDTVVAIPYGSRHI---------------RLVLKGPDHLYLETKTLQGTKGENSLSSTGT 246
Query: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
L + S+ F+ P+ +++ F K++ + + V F
Sbjct: 247 FLVDNSSV-------DFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI------- 292
Query: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPEDAKP 881
QP++H +W D+ CS+TCG G+Q + EC D S + A PE+ KP
Sbjct: 293 ----FYQPIIH-RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKP 347
Query: 882 ------CESQLCP 888
C CP
Sbjct: 348 KPKLQECNLDPCP 360
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/48 (35%), Positives = 25/48 (52%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPC 882
+W+ +WS C+ TCG G + R V C D G + C+ KP + C
Sbjct: 439 KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
Score = 39.3 bits (90), Expect = 0.016
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 6/60 (10%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
+W W+ CSS+CG G Q R V C + Q T C K A+PC CP
Sbjct: 379 RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 30.8 bits (68), Expect = 5.8
Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKY-------QSCHTEECP 581
PW CS +CGGG+Q C + + Q + Y Q C+ +CP
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP 438
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 162 bits (411), Expect = 1e-39
Identities = 101/296 (34%), Positives = 144/296 (48%), Gaps = 27/296 (9%)
Query: 529 WAPWGPWGECSRTCGGGVQFSHREC----KDPEPQNGGRYCLGRRAKYQSCHTEECPPDG 584
W W W CSR+CGGGV R C + P G R C G +YQ C +ECPPDG
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 585 KSFREQQCEKYNAYNYTDMDGNLLQWVP----KYAGVSPRDRCKLFCRARGRSEFKVFEA 640
+SFRE+QC +N++ Y +G QW P Y +S + C L C + A
Sbjct: 110 RSFREEQCVSFNSHVY---NGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPA 165
Query: 641 KVIDGTLCGPETL-AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT 699
+ DGT C L +CV G+C GCD V+ S LDKCG+C G G+SC V+G+
Sbjct: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 700 N--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDI 757
N GY+ + IPAGA +I + +R + + LAL G Y NGN + + ++
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PKNF 277
Query: 758 LVKGTILKYSGSI----ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
+ GT++KY + +E + + P + L V + G+ +YT P
Sbjct: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Score = 47.0 bits (110), Expect = 8e-05
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 2/65 (3%)
Query: 826 NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCE 883
N P QW + DW CS +CG G R V C+ G+ + C KP PC
Sbjct: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
Query: 884 SQLCP 888
+ CP
Sbjct: 791 DKNCP 795
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 8/61 (13%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCN-----KALKPEDAKPCESQL 886
+W WSECS TCG G+Q R V C P +S + +A++PE+ K C +
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 887 C 887
C
Sbjct: 685 C 685
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
+W WSEC+ TCG G + R V+C + C+ +KP + C+ Q CP
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCP 908
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 5/59 (8%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD-----PSGQASATCNKALKPEDAKPCESQLC 887
A W+ DW C++TCG G ++R V C + P ++ C A KP + C + C
Sbjct: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
Score = 35.0 bits (79), Expect = 0.31
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPED 878
+ER T P QW + +WSEC++ CG R+V RD + C+ +P
Sbjct: 675 EERKTCR--NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVG 728
Query: 879 AKPCESQLC 887
K C C
Sbjct: 729 EKNCTGPPC 737
Score = 35.0 bits (79), Expect = 0.31
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583
PW EC++TCG GV+ +C G L + Q+C + CP +
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
Score = 31.6 bits (70), Expect = 3.4
Identities = 12/19 (63%), Positives = 12/19 (63%)
Query: 535 WGECSRTCGGGVQFSHREC 553
W ECSRTCG G QF C
Sbjct: 631 WSECSRTCGEGYQFRVVRC 649
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 162 bits (411), Expect = 1e-39
Identities = 101/296 (34%), Positives = 144/296 (48%), Gaps = 27/296 (9%)
Query: 529 WAPWGPWGECSRTCGGGVQFSHREC----KDPEPQNGGRYCLGRRAKYQSCHTEECPPDG 584
W W W CSR+CGGGV R C + P G R C G +YQ C +ECPPDG
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 585 KSFREQQCEKYNAYNYTDMDGNLLQWVP----KYAGVSPRDRCKLFCRARGRSEFKVFEA 640
+SFRE+QC +N++ Y +G QW P Y +S + C L C + A
Sbjct: 110 RSFREEQCVSFNSHVY---NGRTHQWKPLYPDDYVHISSKP-CDLHCTTVDGQRQLMVPA 165
Query: 641 KVIDGTLCGPETL-AICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT 699
+ DGT C L +CV G+C GCD V+ S LDKCG+C G G+SC V+G+
Sbjct: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 700 N--YGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDI 757
N GY+ + IPAGA +I + +R + + LAL G Y NGN + + ++
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVER-----KKSADVLALADEAGYYFFNGNYKVDS-PKNF 277
Query: 758 LVKGTILKYSGSI----ATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVP 809
+ GT++KY + +E + + P + L V + G+ +YT P
Sbjct: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQP 333
Score = 47.0 bits (110), Expect = 8e-05
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 2/65 (3%)
Query: 826 NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCE 883
N P QW + DW CS +CG G R V C+ G+ + C KP PC
Sbjct: 731 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 790
Query: 884 SQLCP 888
+ CP
Sbjct: 791 DKNCP 795
Score = 45.1 bits (105), Expect = 3e-04
Identities = 22/61 (36%), Positives = 31/61 (50%), Gaps = 8/61 (13%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCN-----KALKPEDAKPCESQL 886
+W WSECS TCG G+Q R V C P +S + +A++PE+ K C +
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 887 C 887
C
Sbjct: 685 C 685
Score = 44.7 bits (104), Expect = 4e-04
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Query: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
+W WSEC+ TCG G + R V+C + C+ +KP + C+ Q CP
Sbjct: 856 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCP 908
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 5/59 (8%)
Query: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD-----PSGQASATCNKALKPEDAKPCESQLC 887
A W+ DW C++TCG G ++R V C + P ++ C A KP + C + C
Sbjct: 796 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 854
Score = 35.0 bits (79), Expect = 0.31
Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 820 KERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRD-PSGQASATCNKALKPED 878
+ER T P QW + +WSEC++ CG R+V RD + C+ +P
Sbjct: 675 EERKTCR--NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVG 728
Query: 879 AKPCESQLC 887
K C C
Sbjct: 729 EKNCTGPPC 737
Score = 35.0 bits (79), Expect = 0.31
Identities = 16/50 (32%), Positives = 24/50 (48%)
Query: 534 PWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583
PW EC++TCG GV+ +C G L + Q+C + CP +
Sbjct: 861 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
Score = 31.6 bits (70), Expect = 3.4
Identities = 12/19 (63%), Positives = 12/19 (63%)
Query: 535 WGECSRTCGGGVQFSHREC 553
W ECSRTCG G QF C
Sbjct: 631 WSECSRTCGEGYQFRVVRC 649
>gi|226442878 ADAMTS-like 5 [Homo sapiens]
Length = 471
Score = 152 bits (383), Expect = 2e-36
Identities = 97/288 (33%), Positives = 135/288 (46%), Gaps = 23/288 (7%)
Query: 527 GGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKS 586
G W PW W CS +CG GV R C G C G +Y+ C +CPP
Sbjct: 36 GEWTPWVSWTRCSSSCGRGVSVRSRRCLRLP---GEEPCWGDSHEYRLCQLPDCPPGAVP 92
Query: 587 FREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGT 646
FR+ QC YN QWVP + + +C L C A G + + F +V+DGT
Sbjct: 93 FRDLQCALYNGRPVLGTQ-KTYQWVPFHGAPN---QCDLNCLAEGHAFYHSF-GRVLDGT 147
Query: 647 LCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN--YGYN 704
C P +CV G+C+ AGCD ++ S D+CG CGG +SC V GY
Sbjct: 148 ACSPGAQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYW 207
Query: 705 DIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTIL 764
++ IP GA +I V+ RS N+LAL DG+Y+LNG+ +S GT +
Sbjct: 208 NVTLIPEGARHIRVEHRSR-------NHLALMGGDGRYVLNGHWVVSP-PGTYEAAGTHV 259
Query: 765 KYSGSIATLERLQSFRPLPEPLTVQ-LLTVPGEVFPPKVKYTFFVPND 811
Y+ E LQ+ P L +Q LL P P +++ F++P +
Sbjct: 260 VYTRDTGPQETLQAAGPTSHDLLLQVLLQEPN----PGIEFEFWLPRE 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,342,670
Number of Sequences: 37866
Number of extensions: 2369468
Number of successful extensions: 14121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 11803
Number of HSP's gapped (non-prelim): 1673
length of query: 889
length of database: 18,247,518
effective HSP length: 111
effective length of query: 778
effective length of database: 14,044,392
effective search space: 10926536976
effective search space used: 10926536976
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.