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Search of human proteins with 151301098
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens]
(2354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens] 4725 0.0
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 52 7e-06
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 51 1e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 51 2e-05
gi|5729734 activator of S phase kinase [Homo sapiens] 50 3e-05
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 49 6e-05
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 49 6e-05
gi|71061468 centromere protein E [Homo sapiens] 49 8e-05
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 48 1e-04
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 47 2e-04
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 47 2e-04
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 47 2e-04
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 47 3e-04
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 47 3e-04
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 46 4e-04
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 46 4e-04
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 46 4e-04
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 46 4e-04
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens] 46 5e-04
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 45 6e-04
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 45 8e-04
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 45 0.001
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 45 0.001
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 45 0.001
gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo sa... 45 0.001
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 44 0.002
gi|19923599 calmin [Homo sapiens] 44 0.002
gi|39545580 cereblon [Homo sapiens] 44 0.002
gi|58530840 desmoplakin isoform I [Homo sapiens] 42 0.005
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 42 0.005
>gi|151301098 zinc finger, DBF-type containing 2 [Homo sapiens]
Length = 2354
Score = 4725 bits (12256), Expect = 0.0
Identities = 2354/2354 (100%), Positives = 2354/2354 (100%)
Query: 1 MQKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQ 60
MQKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQ
Sbjct: 1 MQKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQ 60
Query: 61 ESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSR 120
ESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSR
Sbjct: 61 ESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSR 120
Query: 121 PHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRP 180
PHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRP
Sbjct: 121 PHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRP 180
Query: 181 PVICNAPASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVP 240
PVICNAPASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVP
Sbjct: 181 PVICNAPASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVP 240
Query: 241 SSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRV 300
SSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRV
Sbjct: 241 SSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRV 300
Query: 301 KSPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSV 360
KSPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSV
Sbjct: 301 KSPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSV 360
Query: 361 SSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQ 420
SSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQ
Sbjct: 361 SSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQ 420
Query: 421 SKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHI 480
SKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHI
Sbjct: 421 SKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHI 480
Query: 481 SLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSA 540
SLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSA
Sbjct: 481 SLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSA 540
Query: 541 DSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTV 600
DSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTV
Sbjct: 541 DSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTV 600
Query: 601 KGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMN 660
KGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMN
Sbjct: 601 KGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMN 660
Query: 661 CESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHD 720
CESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHD
Sbjct: 661 CESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHD 720
Query: 721 EPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLED 780
EPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLED
Sbjct: 721 EPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLED 780
Query: 781 ESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSG 840
ESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSG
Sbjct: 781 ESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSG 840
Query: 841 NDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEE 900
NDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEE
Sbjct: 841 NDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEE 900
Query: 901 QVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDS 960
QVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDS
Sbjct: 901 QVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDS 960
Query: 961 DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK 1020
DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK
Sbjct: 961 DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK 1020
Query: 1021 INRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKI 1080
INRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKI
Sbjct: 1021 INRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKI 1080
Query: 1081 TFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNL 1140
TFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNL
Sbjct: 1081 TFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNL 1140
Query: 1141 GNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVS 1200
GNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVS
Sbjct: 1141 GNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVS 1200
Query: 1201 FDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEV 1260
FDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEV
Sbjct: 1201 FDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEV 1260
Query: 1261 VKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDK 1320
VKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDK
Sbjct: 1261 VKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDK 1320
Query: 1321 GYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADE 1380
GYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADE
Sbjct: 1321 GYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADE 1380
Query: 1381 LQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHN 1440
LQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHN
Sbjct: 1381 LQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHN 1440
Query: 1441 DLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMMY 1500
DLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMMY
Sbjct: 1441 DLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMMY 1500
Query: 1501 DSDVPFQIVVNQFPGSVKETHLPKVVLVDLVPGDSDYEVISDDIPLQLVTDPPQLTVKDI 1560
DSDVPFQIVVNQFPGSVKETHLPKVVLVDLVPGDSDYEVISDDIPLQLVTDPPQLTVKDI
Sbjct: 1501 DSDVPFQIVVNQFPGSVKETHLPKVVLVDLVPGDSDYEVISDDIPLQLVTDPPQLTVKDI 1560
Query: 1561 SCINTECIDIEDKSCDFFGSEVRCNCKASTPSMTNQCKETFKIINRKKDYIILGEPSCQS 1620
SCINTECIDIEDKSCDFFGSEVRCNCKASTPSMTNQCKETFKIINRKKDYIILGEPSCQS
Sbjct: 1561 SCINTECIDIEDKSCDFFGSEVRCNCKASTPSMTNQCKETFKIINRKKDYIILGEPSCQS 1620
Query: 1621 CGSEMNFNVDASDQSMTYESQGPDEKMVKYIDSEDKSCGYNGSKGKFNLEDTSHRTTHRL 1680
CGSEMNFNVDASDQSMTYESQGPDEKMVKYIDSEDKSCGYNGSKGKFNLEDTSHRTTHRL
Sbjct: 1621 CGSEMNFNVDASDQSMTYESQGPDEKMVKYIDSEDKSCGYNGSKGKFNLEDTSHRTTHRL 1680
Query: 1681 QKAHKEASLRKDPRNAGLKGKSCQSSASAVDFGASSKSALHRRADKKKRSKLKHRDLEVS 1740
QKAHKEASLRKDPRNAGLKGKSCQSSASAVDFGASSKSALHRRADKKKRSKLKHRDLEVS
Sbjct: 1681 QKAHKEASLRKDPRNAGLKGKSCQSSASAVDFGASSKSALHRRADKKKRSKLKHRDLEVS 1740
Query: 1741 CEPDGFEMNFQCAPPLPSDTDQPQETVKKRHPCKKVSSDLKEKNHDSQSSSVLKVDSVRN 1800
CEPDGFEMNFQCAPPLPSDTDQPQETVKKRHPCKKVSSDLKEKNHDSQSSSVLKVDSVRN
Sbjct: 1741 CEPDGFEMNFQCAPPLPSDTDQPQETVKKRHPCKKVSSDLKEKNHDSQSSSVLKVDSVRN 1800
Query: 1801 LKKAKDVIEDNPDEPVLEALPHVPPSFVGKTWSQIMREDDIKINALVKEFREGRFHCYFD 1860
LKKAKDVIEDNPDEPVLEALPHVPPSFVGKTWSQIMREDDIKINALVKEFREGRFHCYFD
Sbjct: 1801 LKKAKDVIEDNPDEPVLEALPHVPPSFVGKTWSQIMREDDIKINALVKEFREGRFHCYFD 1860
Query: 1861 DDCETKKVSSKGKKKVTWADLQGKEDTAPTQAVSESDDIVCGISDIDDLSVALDKPCHRH 1920
DDCETKKVSSKGKKKVTWADLQGKEDTAPTQAVSESDDIVCGISDIDDLSVALDKPCHRH
Sbjct: 1861 DDCETKKVSSKGKKKVTWADLQGKEDTAPTQAVSESDDIVCGISDIDDLSVALDKPCHRH 1920
Query: 1921 PPAERPPKQKGRVASQCQTAKISHSTQTSCKNYPVMKRKIIRQEEDPPKSKCSRLQDDRK 1980
PPAERPPKQKGRVASQCQTAKISHSTQTSCKNYPVMKRKIIRQEEDPPKSKCSRLQDDRK
Sbjct: 1921 PPAERPPKQKGRVASQCQTAKISHSTQTSCKNYPVMKRKIIRQEEDPPKSKCSRLQDDRK 1980
Query: 1981 TKKKVKIGTVEFPASCTKVLKPMQPKALVCVLSSLNIKLKEGEGLPFPKMRHHSWDNDIR 2040
TKKKVKIGTVEFPASCTKVLKPMQPKALVCVLSSLNIKLKEGEGLPFPKMRHHSWDNDIR
Sbjct: 1981 TKKKVKIGTVEFPASCTKVLKPMQPKALVCVLSSLNIKLKEGEGLPFPKMRHHSWDNDIR 2040
Query: 2041 FICKYKRNIFDYYEPLIKQIVISPPLSVIVPEFERRNWVKIHFNRSNQNSSAGDNDADGQ 2100
FICKYKRNIFDYYEPLIKQIVISPPLSVIVPEFERRNWVKIHFNRSNQNSSAGDNDADGQ
Sbjct: 2041 FICKYKRNIFDYYEPLIKQIVISPPLSVIVPEFERRNWVKIHFNRSNQNSSAGDNDADGQ 2100
Query: 2101 GSASAPLMAVPARYGFNSHQGTSDSSLFLEESKVLHARELPKKRNFQLTFLNHDVVKISP 2160
GSASAPLMAVPARYGFNSHQGTSDSSLFLEESKVLHARELPKKRNFQLTFLNHDVVKISP
Sbjct: 2101 GSASAPLMAVPARYGFNSHQGTSDSSLFLEESKVLHARELPKKRNFQLTFLNHDVVKISP 2160
Query: 2161 KSVRNKLLESQSKKKIHGKRVTTSSNKLGFPKKVYKPIILQQKPRKASEKQSIWIRTKPS 2220
KSVRNKLLESQSKKKIHGKRVTTSSNKLGFPKKVYKPIILQQKPRKASEKQSIWIRTKPS
Sbjct: 2161 KSVRNKLLESQSKKKIHGKRVTTSSNKLGFPKKVYKPIILQQKPRKASEKQSIWIRTKPS 2220
Query: 2221 DIIRKYISKYSVFLRHRYQSRSAFLGRYLKKKKSVVSRLKKAKRTAKVLLNSSVPPAGAE 2280
DIIRKYISKYSVFLRHRYQSRSAFLGRYLKKKKSVVSRLKKAKRTAKVLLNSSVPPAGAE
Sbjct: 2221 DIIRKYISKYSVFLRHRYQSRSAFLGRYLKKKKSVVSRLKKAKRTAKVLLNSSVPPAGAE 2280
Query: 2281 ELSSAMANPPPKRPVRASCRVARRRKKTDESYHGRQKGPSTPVRAYDLRSSSCLQQRERM 2340
ELSSAMANPPPKRPVRASCRVARRRKKTDESYHGRQKGPSTPVRAYDLRSSSCLQQRERM
Sbjct: 2281 ELSSAMANPPPKRPVRASCRVARRRKKTDESYHGRQKGPSTPVRAYDLRSSSCLQQRERM 2340
Query: 2341 MTRLANKLRGNEVK 2354
MTRLANKLRGNEVK
Sbjct: 2341 MTRLANKLRGNEVK 2354
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 52.0 bits (123), Expect = 7e-06
Identities = 200/1092 (18%), Positives = 427/1092 (39%), Gaps = 161/1092 (14%)
Query: 323 EDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETA 382
++++A+++ + ++ ++EK L+ + E++ + L + + + TA
Sbjct: 410 DNSLAEDNLKLKMRIEVLEKEKSLLSQE----------KEELQMSLLKLNNEYEVIKSTA 459
Query: 383 -QDLSLWKEEQIDQEDNYESRGSEMSFDCS------SSFHSLTDQSKVSAKEVNLSKEVR 435
+D+SL E D N E++ E++ S + L Q++ + K + L K+ +
Sbjct: 460 TRDISL-DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD-Q 517
Query: 436 TDVQYKNNKSYVSKISSDCDDI---LHLVTNQSQMIVKEISLQNAR----HISLVDQSYE 488
Q S +SK+ D +D +H + + I KE+ +Q + ++L D
Sbjct: 518 LSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLT 577
Query: 489 SSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSADSVFPLQS 548
E + + S S+ + NL + HI ++ +E+ S
Sbjct: 578 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS 637
Query: 549 VVDRPPVAVTETKLRK-KAHTSLVDNYGSSCSETSFDCDVSLESVV-------------- 593
+ E ++R K + S ++ + + +FD + E +V
Sbjct: 638 NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
Query: 594 -DHPQLTVKGRN----LKGRQVHLKH-----KKRKPSSAKAHLDCDVSLGTVADESQRAV 643
+ QL+++ LK + ++ KKR A + L + + A+
Sbjct: 698 AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757
Query: 644 E-------KINLLKEKNADLMDMNCESHGPEMGFQAD---AQLADQSQVAEIERQKVDVD 693
+ K+N K+ + N E + D + L +Q Q+ ++ +K ++
Sbjct: 758 QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK-EIF 816
Query: 694 LENKSVQSSRSSLSSDSPAS------LYHSAHDEPQEALDEVNLKELNIDMEVRSYDCSS 747
+E +SS+ D + + +E +L + + ++ E+
Sbjct: 817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
Query: 748 SELTFDSDPPLL-SVTE-----------QSHLDAEGKERHIDLEDESCESDSSEITFDSD 795
S +DP L SVTE + HL+ E K +ED++ S
Sbjct: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQN----------QSK 926
Query: 796 IPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKE 855
+ L + + + E + + + + +++ + D + S K + Q +
Sbjct: 927 MQLLQSLQEQKK---EMDEFRYQHEQMNATHTQLFLEKDEEIKS-------LQKTIEQIK 976
Query: 856 EYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSE 915
+H ER++ + S+I ++ ++ N E L+ + E++ KE E ++ +
Sbjct: 977 TQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK--HDLSKAETERLVKGIKERE-LEIK 1033
Query: 916 VSLDYNI-IFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVI 974
+ + NI + + S+D + +++ ++ K + +L + + + +H +V+
Sbjct: 1034 LLNEKNISLTKQIDQLSKDEVGKLT------QIIQQKDLEIQALHARI--SSTSHTQDVV 1085
Query: 975 VKETWLQ-----REK-HAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQ-VAVNKINRKKQY 1027
+ LQ REK A ++ E S KT + + E + + N+K
Sbjct: 1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLST 1145
Query: 1028 VLENKNDKC------SGSEIILDSNVPPQSMTDQPQ--LAFLKEKHVNLKDKNSKSGD-S 1078
E+ + S II + ++ +++ + Q LA L+ + S
Sbjct: 1146 RFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFE 1205
Query: 1079 KITFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVAD---QPKVAI 1135
++ + ++L++ VKK+++WK++V+ + S + Q + D K+ +
Sbjct: 1206 ELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQV 1265
Query: 1136 KHVNL-----GNENHMY---LEVKNSQYSCSEM-NLDSGFLGQSIVNRPQI---TILEQE 1183
+ L NE + E+ Q+S ++ N LG+ + PQ+ ++L +
Sbjct: 1266 DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ 1325
Query: 1184 HIELEGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEI 1243
E + SEV +S + LQ + LR++++E KD + T N I
Sbjct: 1326 SAEC----LRASKSEVLSESSELLQQELEELRKSLQE----KDATIRTLQENNHRLSDSI 1377
Query: 1244 MYDSDVLQPVAGQPEEVVKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQS---VTNKI 1300
S++ + Q + +K++ KE D+ K++K D I S + L S TNK+
Sbjct: 1378 AATSELERKEHEQTDSEIKQL---KEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
Query: 1301 PGANKEINLLRE 1312
E LLR+
Sbjct: 1435 ----NENELLRQ 1442
Score = 33.9 bits (76), Expect = 1.9
Identities = 147/853 (17%), Positives = 343/853 (40%), Gaps = 133/853 (15%)
Query: 586 DVSLESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEK 645
D+SL+S + +L NL+ ++ L + + A ++ + ++Q A +
Sbjct: 462 DISLDSELHDLRL-----NLEAKEQELNQSISEKETLIAEIE------ELDRQNQEATKH 510
Query: 646 INLLKEKNADLMDMNCESHGPEMGFQADAQLADQSQ-VAEIERQKVDV--DLENKSVQSS 702
+ L+K++ + ++ G + + L D+ + V ++E K+D+ +L+ + +
Sbjct: 511 MILIKDQLSKQ-----QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI 565
Query: 703 RSSLSSDSPASLYHSAHDEPQEALDEVNL-KELNIDMEVRSYDC------SSSELTFDSD 755
+S ++ + D+ + +D++N +E N+ ++ + + + EL+ +
Sbjct: 566 QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 625
Query: 756 PPLLSVTEQSHLDAEG---KERHIDLED--------ESCESDSSEITFDSDIPLYSVIDQ 804
+ S+ + S+ + + KER ++ + E + ++ FD + ++
Sbjct: 626 ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
Query: 805 PEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERKN 864
E ++ E + + +N+ + + T + + G E+ + EE E+
Sbjct: 686 CEDVRHQLE--ECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI 743
Query: 865 DEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNIIF 924
+E S + + S L + KLN +K+ ++ K E +D++ +++
Sbjct: 744 EELSNARNLNTSALQLE------HEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLS 797
Query: 925 HSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQR-- 982
S+ E+ + L K+ +++E + L ++ + + I+++T ++
Sbjct: 798 SSL----EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 983 ----------------EKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQ 1026
E+ E Q R+ + KT LDS VTE V+++N K+
Sbjct: 854 SLGSMKEENNHLQEELERLREEQSRTAPVADPKT-LDS------VTELASEVSQLNTIKE 906
Query: 1027 YVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQ 1086
++ E +II D N Q ++ L+ K+ + + + EQ
Sbjct: 907 HLEEEIKHH---QKIIEDQN--------QSKMQLLQSLQEQKKEMD------EFRYQHEQ 949
Query: 1087 LQEAVKKIDQWK-EEVIGLKNKINEPSTYKLIHHPDVSVQS--VADQPKVAIKHVNLGNE 1143
+ ++ K EE+ L+ I + T D+ + + + KV ++ G+E
Sbjct: 950 MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSE 1009
Query: 1144 NHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRP-QITILEQEHIELEGKHNQCCGSEVSFD 1202
H + + + L + I R +I +L +++I L + +Q EV
Sbjct: 1010 KHDLSKAETER------------LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG-- 1055
Query: 1203 SDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGF--EIMYDSDVLQPVAGQPEEV 1260
+L + +++ KD E+ R + +++Y LQ A + E+V
Sbjct: 1056 ----------KLTQIIQQ----KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKV 1101
Query: 1261 VKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDK 1320
++ EN +K T+ D ++ K+ NK+++ E +
Sbjct: 1102 FAVLN----EKTRENSHLK-TEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFR 1156
Query: 1321 GYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADE 1380
+ + S II +I + ++ ++ L A L+ S+ + + +S+ + D+
Sbjct: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLL---AVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
Query: 1381 LQKPVKEINLWKE 1393
L++ VK++ WK+
Sbjct: 1214 LKQQVKKMEEWKQ 1226
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 51.2 bits (121), Expect = 1e-05
Identities = 140/738 (18%), Positives = 243/738 (32%), Gaps = 58/738 (7%)
Query: 195 SNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKH 254
S+D + + +S + DS SK D + + S + SS+ +S S
Sbjct: 616 SSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSS 675
Query: 255 KESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTD 314
S+ +SD S + S+ + + S S + N + +
Sbjct: 676 DSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Query: 315 MPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSA 374
SN D+ ++ S+ + + + S SS+ D + +
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN-DSSNSSDS 794
Query: 375 SDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQSKVSAKEVNLS--- 431
SD + S + D D+ S S+ S SS S + S S+ + S
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD 854
Query: 432 KEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHISLVDQSYESSS 491
R+D ++ S S S+ D +N+S N+ D S S S
Sbjct: 855 SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 492 SETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVD 551
S+++ D+S S S N SS S S+DS
Sbjct: 915 SDSSNSSDSSESSNS---------------------SDNSNSSDSSNSSDS--------- 944
Query: 552 RPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVH 611
+ D+ SS S S D S +S + + N
Sbjct: 945 ----------------SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988
Query: 612 LKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKN-ADLMDMNCESHGPEMGF 670
SS ++ D S + + +S + + N N +D D + S +
Sbjct: 989 SDSSDSSDSSDSSN-SSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047
Query: 671 QADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVN 730
+D+ + S + D + S SS SS SSDS S S + ++ D +
Sbjct: 1048 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSD 1107
Query: 731 LKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEI 790
+ + + S D S+S + DS S + D+ D D S SDSS+
Sbjct: 1108 SSDSSDSSD--SSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165
Query: 791 TFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKE 850
+ SD S + ++ D S+ S S+ + SD S + +
Sbjct: 1166 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD----SSDSSDSSDSSD 1221
Query: 851 VIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENE 910
+ +D S+ S S++ S ++ + N + + Q N N
Sbjct: 1222 SSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNN 1281
Query: 911 PIDSEVSLDYNIIFHSVT 928
DS+ + + HS +
Sbjct: 1282 GSDSDSDSEGSDSNHSTS 1299
Score = 31.6 bits (70), Expect = 9.6
Identities = 31/135 (22%), Positives = 55/135 (40%), Gaps = 2/135 (1%)
Query: 744 DCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEITFDSDIPLYSVID 803
D S S + DSD ++ S D+ D D S SDSS+ + SD S
Sbjct: 570 DSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS 629
Query: 804 QPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERK 863
+ + + + ++ +S S++S + + DS +S + + + +
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689
Query: 864 ND--EPSGSEISSDS 876
+D + S S SSDS
Sbjct: 690 SDSSDSSNSSESSDS 704
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 50.8 bits (120), Expect = 2e-05
Identities = 228/1239 (18%), Positives = 477/1239 (38%), Gaps = 171/1239 (13%)
Query: 252 QKHKESNR-KSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRVKSPSKLAVNP 310
Q+ E+ R + L + S ++ K+Q K L+ L+ + K + V
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK-------EITVMVEK 611
Query: 311 NKTDMPSNK----GIFEDTIAKNHEEFFSNMD-----CTQEEKHLVFNKTAFWEQKCSVS 361
+KT++ S K ++ + + +++ + M+ C QE++ L+ +K ++
Sbjct: 612 HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 362 SEMKFDCIS-----LQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMS--FDCSSSF 414
+E + + L+S S + E + +EE +D + E+ D +
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 415 HSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDIL-----HLVTNQSQMIV 469
H S + EV++ RT+ K+ + + + + D L H+ ++ +
Sbjct: 732 HQQQVDSIIKEHEVSIQ---RTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 470 KEISLQNARHISLVDQSYESSSSE-TNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVD 528
E LQ A V QSY+S++ E T + Q + L K+V V+
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV--AEVE 846
Query: 529 KNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVS 588
+E+ A + +Q ++ + +E + + K SL Y S + + + + +
Sbjct: 847 AQKKDVCTELDAHKI-QVQDLMQQLEKQNSEMEQKVK---SLTQVYESKLEDGNKEQEQT 902
Query: 589 LESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINL 648
+ +V+ + ++ R + +++ + +K H+ + T ++ +EK+
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI-LNEEYETKFKNQEKKMEKV-- 959
Query: 649 LKEKNADLMDMNCESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSS 708
K+K ++ + + +A+L + + +E + + K ++ ++++ +
Sbjct: 960 -KQKAKEMQETLKKKL-----LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 709 DSPA-SLYHSAHDEPQEALDEVNLKELN--IDMEVRSYDCSSSELTFDSDPPLLSVTEQS 765
S A S + E E+L EV+ +ELN I + + + + EL + + + E+
Sbjct: 1014 ISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE---IQLQEKE 1070
Query: 766 HLDAEGKERHIDLEDESCESDSSEITF------DSDIPLYSVIDQPEVAVYEEETVDLES 819
AE K++ + E E + EIT+ D L + +Q + ++ +
Sbjct: 1071 QEVAELKQKILLFGCEK-EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Query: 820 KSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSD---- 875
++ + ++ D + L E V+ + EE +RK E + ++D
Sbjct: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED---KRKVSELTSKLKTTDEEFQ 1186
Query: 876 ----SHAPLHSVTNSPEVAVKKLNPQ---------KEEQVHLENKENEPIDSEVSLDYNI 922
SH + + KKL+ + K+ + LE K NE I+ S I
Sbjct: 1187 SLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAI 1246
Query: 923 IFH-SVTGRSEDPIKE---ISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKET 978
+ S +KE I T + + + + E ++ Q ATH+ E KE
Sbjct: 1247 LSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEE--KEN 1304
Query: 979 WLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSG 1038
++ K A+ + TE + + G + +E + + ++ K+ + EN N
Sbjct: 1305 QIKSMK-ADIESLVTEKEALQK--EGGNQQQAASEKESCITQL---KKELSENINAVTLM 1358
Query: 1039 SEIILDSNVPPQSMTDQ-PQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQ--------- 1088
E + + V S++ Q L + ++L +K + + +D E+ +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS 1418
Query: 1089 -----------EAVKKIDQWKEEVIGLKNKINEPSTY--KLIHHPDVSVQSVADQPKVAI 1135
A++++D W + K K T + + ++ + +
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
Query: 1136 KHVNLGNENHMYLEVKNSQYSC--------------SEMNLDSGFLGQSIVNRPQITILE 1181
+ +NL E L+ +N ++ C E NL++ Q+ +
Sbjct: 1479 EQINLLKEE---LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 1182 QEHIELEGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGF 1241
Q+ IE+E + D + +E V+++ +++ + ++R EA+
Sbjct: 1536 QKTIEIESLNEVLKNYNQQKDIEH---------KELVQKLQHFQELGEEKDNRVKEAEEK 1586
Query: 1242 EIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDLENKI----VKPTDSRINFDSHEPL---- 1293
+ ++ V A + E KE+ EHV+L K +K + R+ +S L
Sbjct: 1587 ILTLENQVYSMKA-ELETKKKEL----EHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 1294 QSVTNKIPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHAS 1353
+ KI K++ EE KG SE+ N LQ ++ HILEE+ S
Sbjct: 1642 RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL----NTKLQEREREVHILEEKLKS 1697
Query: 1354 LEDKSSN------------SYSPEESSDSNDSFQAAADE 1380
+E S +Y+ +E +DS Q +E
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736
Score = 47.8 bits (112), Expect = 1e-04
Identities = 215/1172 (18%), Positives = 421/1172 (35%), Gaps = 204/1172 (17%)
Query: 242 SHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRVK 301
S ++ + ++ +E KS R ++L K + + KT A K M + K
Sbjct: 389 SRIKQMTTQGEELREQKEKSERAAFEELE--KALSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 302 SPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEE----------KHLVFNKT 351
+ + ++ + ++ K D + K+ EE + + E+ K L +
Sbjct: 447 TSEEERISLQQ-ELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 352 AFWEQKCSVSSEMKFDCISLQSASDQPQETA-QDLSLWKEEQIDQEDN-----------Y 399
F EQ + + + + + +Q + A ++L L K+ + + +N Y
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 400 ESRGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILH 459
+R E+ S +QSK A + K K+NK + ++
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKN-------KHNKEITVMVEKHKTELES 618
Query: 460 LVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYP----QQSVTE 515
L Q + +++ + + Q Y++ + C+ ++ Q + E
Sbjct: 619 LKHQQDALWTEKLQV--------LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 516 VNLPKEVHIGLVDKNYGSSSSEVSA---------DSVFPLQSVVDRPPVAVTETKL--RK 564
+N + + S SSE+S + + L+ D+ + E K+ +K
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL-EAKMDEQK 729
Query: 565 KAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRN--LKGRQVH-------LKHK 615
H VD+ + + +L+ ++ +L +K R+ LK Q H +K
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRS 789
Query: 616 KRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQ 675
+ + A A LD S + E +A E+ L + L+D+ E +
Sbjct: 790 EGELQQASAKLDVFQSYQSATHEQTKAYEE--QLAQLQQKLLDLETE------------R 835
Query: 676 LADQSQVAEIERQKVDVD-------------LENKSVQSSRSSLSSDSPASLYHSAHDE- 721
+ QVAE+E QK DV ++ Q+S S +Y S ++
Sbjct: 836 ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895
Query: 722 --PQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQS-HLDAEGKERHIDL 778
QE ++ +++ N+ +++R E+ LS E S H+ E E
Sbjct: 896 NKEQEQTKQILVEKENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYETKFKN 951
Query: 779 EDESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNE----SCVSEITFDSD 834
+++ E + + ++DQ E E LE E + + E+ +
Sbjct: 952 QEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 835 IPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKL 894
+ E KE I+ +H ND S + KKL
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVIS--------------------IWEKKL 1051
Query: 895 NPQKEE-----QVHLENKENEPIDSEVSL-----DYNIIFHSVTGRSEDPIKEISLHTKE 944
N Q EE ++ L+ KE E + + + + + +T E+ +K+ + +
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
Query: 945 HMYLENKSVFETSLDSD-VPLQAATHKPEV-----IVKETWLQRE--------------- 983
L+ KS SL D L+A K EV + + T+LQ +
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 984 ---------KHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAV--NKINRKKQYVLENK 1032
EFQ + S SL+ + ++A+ + +K + +LE K
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231
Query: 1033 -----NDKCSGSEIILDSNVPPQSMTDQPQLAFL------KEKHVNLKDKNSKSGDSKIT 1081
N S + IL Q T + + A L E L+ + I+
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNIS 1291
Query: 1082 FDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYK-LIHHPDVSVQSVADQPKVAIKHV-- 1138
F Q+A ++++ + ++ +K I T K + + Q A + + I +
Sbjct: 1292 F-----QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK 1346
Query: 1139 ----NLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHN-Q 1193
N+ M E+K + S ++ L + N ++ E L +++ +
Sbjct: 1347 ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE 1406
Query: 1194 CCG-----SEVSFDSDDPLQ---SVADRLRETVKEISLWKDE-EVDTEDRRNEAKGFEIM 1244
C ++SF D + S +++ + + S WK + + +N K +I
Sbjct: 1407 KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQ 1466
Query: 1245 YDSDVLQPVAGQPEEVVKEVSLWKEHVDLENK 1276
L+ + + E ++++L KE +D +NK
Sbjct: 1467 -----LELKSKEAYEKDEQINLLKEELDQQNK 1493
Score = 39.3 bits (90), Expect = 0.046
Identities = 246/1369 (17%), Positives = 493/1369 (36%), Gaps = 271/1369 (19%)
Query: 5 QGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQ--DV---LQHHPYHC 59
Q Y S Q E+ L Q + L ++ R + T + E Q DV L H
Sbjct: 804 QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV 863
Query: 60 Q------ESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDAT----EERPSE 109
Q E +++ E V + + L+D E+E+ + VE E+ E + E
Sbjct: 864 QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 110 VSEPIEELHSRPHKSQEGTQEVSVR-PSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIG 168
+ ++L ++ +E + + +K+EK +Q+ E + +
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 169 QATNNRSNLVRPPVICNAPASCLPESSN----DRPVTANTTSLPPAAHLDSVSKCDPNKV 224
+ N L + NA + ++++ D T L V + + N V
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 1043
Query: 225 EKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDV---KSQGKT 281
E+ + H Q+ E +K L +K + K++ K +G
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103
Query: 282 LSAGLKFHERMGTKGSLRVKS----PSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNM 337
L + + S V S +KL + K ++ NK + E+T + E+
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQ--EQLVELK 1161
Query: 338 DCTQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQED 397
+E+K V T+ K + E + SL+S+ ++ ++ +D SL
Sbjct: 1162 MLAEEDKRKVSELTS----KLKTTDE---EFQSLKSSHEKSNKSLEDKSL---------- 1204
Query: 398 NYESRGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDI 457
++ E++ Q + K+ E +T+ + S + I S
Sbjct: 1205 EFKKLSEELAI-----------QLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 458 LHLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVN 517
H T VKE L +S ++ + E Q+T + Q T
Sbjct: 1254 QHRTTK-----VKEALLIKTCTVSELEAQLRQLTEE---------QNTLNISFQQATHQL 1299
Query: 518 LPKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSS 577
KE I + + S +E A LQ A +E + S
Sbjct: 1300 EEKENQIKSMKADIESLVTEKEA-----LQKEGGNQQQAASEKE--------------SC 1340
Query: 578 CSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVAD 637
++ + ++ +V T+ LK ++V + ++ + L +SL
Sbjct: 1341 ITQLKKELSENINAV------TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS---- 1390
Query: 638 ESQRAVEKINL-LKEKNADLMDMNCESHGPEMGFQADAQLADQSQVAEIERQKVDVDLEN 696
E + A+ + E+ +L+D ++ F+ D ++ E + E
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQV-----QDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 697 KSVQSSRSSLSSDSPASLYHSAHDEPQEALD---EVNLKELNIDMEVRSYDCSSSELTFD 753
K SR + ++ L + +EA + ++NL + +D + + +DC E+ D
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 754 SDPPLLSVTEQSHLDAEGKE---RHIDLEDESCESDSSEITFDSDIPLYSVIDQPEVAVY 810
++S+L+ E K R ++LED
Sbjct: 1506 KSK---MEKKESNLETELKSQTARIMELEDH----------------------------I 1534
Query: 811 EEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGS 870
++T+++ES ++E+ L + N ++ KE++QK ++
Sbjct: 1535 TQKTIEIES------LNEV-------LKNYNQQKDIEHKELVQKLQHFQ----------- 1570
Query: 871 EISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNIIFHSVTGR 930
E+ +K N KE + + EN+ + L+ T +
Sbjct: 1571 -----------------ELGEEKDNRVKEAEEKILTLENQVYSMKAELE--------TKK 1605
Query: 931 SEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQREKHAEFQG 990
E +S+ +KE E E L+S+ + A K + K ++++ ++ +
Sbjct: 1606 KELEHVNLSVKSKE----EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE 1661
Query: 991 RSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSGSEIILDSNVPPQ 1050
+ ++ S H S ++ + ++ ++LE K S+ ++ + P+
Sbjct: 1662 KEEQYKKGTES------HLSELNTKL---QEREREVHILEEKLKSVESSQ--SETLIVPR 1710
Query: 1051 SMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVK---KIDQWKEEVIGLKNK 1107
S + A+ +++ + + K+ + KI+ L E K ++ Q KEE + +
Sbjct: 1711 SAKN--VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFE 1768
Query: 1108 INEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLEVKNSQYSCSEMNLDSGFL 1167
+ +LI + DQ + +L E LE KN +YS
Sbjct: 1769 MRCQYQERLIKLEHAEAKQHEDQSMIG----HLQEE----LEEKNKKYS----------- 1809
Query: 1168 GQSIVNRPQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISL---- 1223
++ +H+E EG N + + L++V D +++T++E L
Sbjct: 1810 -----------LIVAQHVEKEGGKN-------NIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 1224 --WKDEEVDT------EDRRNEAKGFEIMYDS-DVLQPVAG--QPEEVVKEVSLWKEHVD 1272
K +E+D+ E R E + Y+ LQ + G +P E+++E + K
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911
Query: 1273 L-ENKIVKPTDSRIN------FDSHEPLQSVTNKIPGANKEINLLREEH 1314
L + K++ +++ N + Q + +I K++ +LR+EH
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH 1960
>gi|5729734 activator of S phase kinase [Homo sapiens]
Length = 674
Score = 50.1 bits (118), Expect = 3e-05
Identities = 55/238 (23%), Positives = 108/238 (45%), Gaps = 35/238 (14%)
Query: 2 QKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHP----- 56
+K++GYC C +Y +LE HL S QHR+ + ++ Q+ ++ + + D +++
Sbjct: 290 KKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQV-VDDIVSKLVFDFVEYEKDTPKK 348
Query: 57 ---YHCQESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDED-------ATEER 106
+ S S + + E V L ++ +ED+ V++++ TE++
Sbjct: 349 KRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKK 408
Query: 107 PSEVSEPIEELHSRPHKSQE---GTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCN 163
+SEPI PH S E +++S + S++ E +Q + + + ++C
Sbjct: 409 LLFISEPI------PHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQL-PLHKNKQEC- 460
Query: 164 LVDIGQATNNRSNLVRPPV---ICNAPASC-----LPESSNDRPVTANTTSLPPAAHL 213
++DI + T + ++L V CN AS ++S +P + T L PA L
Sbjct: 461 ILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDL 518
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 48.9 bits (115), Expect = 6e-05
Identities = 50/216 (23%), Positives = 82/216 (37%), Gaps = 22/216 (10%)
Query: 71 VNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSRPHKSQEGTQE 130
V EV +++ ++++E+DED E E+ EE E +E + + + E +E
Sbjct: 226 VEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEE 285
Query: 131 VSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRPP---VICNAP 187
V VR ++ E G + + + KC G NR+N +C +
Sbjct: 286 V-VREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA 344
Query: 188 ASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVPSSHVETT 247
S + P+ + LP A P+ V+KYLE P E
Sbjct: 345 MSQSLLKTTQEPLARDPVKLPTTA------ASTPDAVDKYLETPGD-----------ENE 387
Query: 248 SFSYQKHKES-NRKSLRMNSDKLVLWKDVKSQGKTL 282
+QK KE K S + W++ + Q K L
Sbjct: 388 HAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 423
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 48.9 bits (115), Expect = 6e-05
Identities = 50/216 (23%), Positives = 82/216 (37%), Gaps = 22/216 (10%)
Query: 71 VNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSRPHKSQEGTQE 130
V EV +++ ++++E+DED E E+ EE E +E + + + E +E
Sbjct: 170 VEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEE 229
Query: 131 VSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRPP---VICNAP 187
V VR ++ E G + + + KC G NR+N +C +
Sbjct: 230 V-VREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA 288
Query: 188 ASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVPSSHVETT 247
S + P+ + LP A P+ V+KYLE P E
Sbjct: 289 MSQSLLKTTQEPLARDPVKLPTTA------ASTPDAVDKYLETPGD-----------ENE 331
Query: 248 SFSYQKHKES-NRKSLRMNSDKLVLWKDVKSQGKTL 282
+QK KE K S + W++ + Q K L
Sbjct: 332 HAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNL 367
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 48.5 bits (114), Expect = 8e-05
Identities = 171/935 (18%), Positives = 373/935 (39%), Gaps = 119/935 (12%)
Query: 610 VHLKHKKRKPSSAKAHLDCDVSLGT--VADESQRAVEKINLLKEKNADL--MDMNCESHG 665
V+L + +K S+ L ++S T + ++++ E++N +++ L D ++
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 666 PEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSD--SPASLYHSAHDEPQ 723
E + +V + ++K D+ +S+Q R L SD ++ ++ +
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967
Query: 724 EALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESC 783
AL+ + + I+ ++S + ++ G ++ DLE ++
Sbjct: 968 NALESLKQHQETINT-LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNT 1026
Query: 784 ESDSSEITFDSDI-----PLYSVIDQP-------EVAVYEEETVDLESKSNESCVSEITF 831
++ ++++ D++I ++S+I + E + E+E + + K N E+T
Sbjct: 1027 QTLTADVK-DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN----IEMTI 1081
Query: 832 DSDIPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAV 891
++ L D E+ ++ I +E H +K E S + + E
Sbjct: 1082 ENQEELRLLGD--ELKKQQEIVAQEKNHAIKKEGELSRT---------CDRLAEVEEKLK 1130
Query: 892 KKLNPQKEEQVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENK 951
+K +E+Q L N + E SE+ N I + ++E KE++L EHM E
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEM--SEMQKKINEIENL---KNELKNKELTL---EHMETERL 1182
Query: 952 SVFETSLDSDVPLQAATHKPEVI--VKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHY 1009
+ + ++ +++ T + +V+ +++++ H R E +G +T + + H
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
Query: 1010 SVTEPQVAVNKINR----KKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKH 1065
+ E Q ++++ R K ++ ++ + S +++ + V + P + + E
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQ 1302
Query: 1066 VNLKDKNSKSGDSKITFDSEQL----QEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPD 1121
+ + + S T DS L E ++ ++++E +K+ E K I
Sbjct: 1303 ETMNELELLTEQST-TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE-- 1359
Query: 1122 VSVQSVADQPKVAIKHVNLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILE 1181
+++ DQ K I+ L + + S + N + + + +P+ + L
Sbjct: 1360 -ALEVKHDQLKEHIRET-LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 1182 QEHIELEGKHNQCCGSE-----VSFDSDD------PLQSVADRLRETVKEISLWKDEEVD 1230
+ IE+ G + S V+ + DD LQS +D+L+E +KEI
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI--------- 1468
Query: 1231 TEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDLENKIVKPTDSRINFDSH 1290
AK E + V + EE + E+ + + E ++ IN
Sbjct: 1469 ------VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQ 1522
Query: 1291 EPLQSVTNK--------IPGANKEINLLRE--EHVCLDDKGYVPSDSEIIYVSNIPLQSV 1340
+Q + K I +++N L++ EH D +S+++ ++N +S
Sbjct: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES- 1581
Query: 1341 IKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADELQKPVKEI-----NLWKEDH 1395
EE +++K EE ++ Q D+L++ KEI ++++
Sbjct: 1582 ------QEEIQIMIKEK-------EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY 1628
Query: 1396 IYLEDKSYKLGDFDVSYASHIPVQFVTDQ---SSVPVKEINLQKKDHNDLENKNCEVCGS 1452
+L+ + + H+ QF T + ++ + I L + H +LE
Sbjct: 1629 QFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKER 1688
Query: 1453 EIKCHSCVHLQSEVDQPQVSYKEA---DLQKEEHV 1484
+ L+ E DQ + + +E DL+K+E +
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEKQEEL 1723
Score = 43.5 bits (101), Expect = 0.002
Identities = 118/630 (18%), Positives = 250/630 (39%), Gaps = 81/630 (12%)
Query: 908 ENEPIDSEVSLDYNII--FHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQ 965
+N P +EVS D ++ + + ++E+SL T+ +E + + + D+ +
Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQA-MEKDQLAQLLEEKDLLQK 388
Query: 966 AATHKPEVIVK------ETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVN 1019
K E + + LQ+E A+ + R T G + + P
Sbjct: 389 VQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITT 448
Query: 1020 KINRKKQYVLENKNDK-CSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDS 1078
K ++ +L ++ CS S++ ++ + P L ++++ + + ++
Sbjct: 449 KTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD 508
Query: 1079 KITFDSEQLQEAVKKID-QWKE-----EVIGLKNKINEPSTYKLIH----------HPDV 1122
+ D EQL+ ++++ + KE E L+ K + +LIH H +V
Sbjct: 509 NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEV 568
Query: 1123 SVQSVADQPKVAIKHVNLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQI--TIL 1180
Q + ++ ++ + + L+ + +D + +SI + Q+ T+
Sbjct: 569 YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628
Query: 1181 EQEHIELEGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISL-WKDEEVDTEDRRNEAK 1239
+ E + L+ K E +F + L+ L+E +KE++ +K E D + +++ +
Sbjct: 629 DAETVALDAKR------ESAFLRSENLE-----LKEKMKELATTYKQMENDIQLYQSQLE 677
Query: 1240 GFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNK 1299
+ M D+ + + E+ K SL ++ K+ P D N + + + +
Sbjct: 678 AKKKM-QVDLEKELQSAFNEITKLTSL------IDGKV--PKDLLCNLELEGKITDLQKE 728
Query: 1300 IPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSS 1359
+ +E LREE + L + +PS+ E + +Q ++ HI+ E +DK
Sbjct: 729 LNKEVEENEALREEVILLSELKSLPSEVERLRKE---IQDKSEELHIITSE----KDKLF 781
Query: 1360 NSYSPEESSDSNDSFQAAADELQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQ 1419
+ +ES +Q ++EI K+D + +YK D + + +
Sbjct: 782 SEVVHKES------------RVQGLLEEIGKTKDD-LATTQSNYKSTDQEFQNFKTLHMD 828
Query: 1420 FVTDQSSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQ 1479
F +Q V E N + +K + S + L++E+ SYK +LQ
Sbjct: 829 F--EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA-----LKTEL-----SYKTQELQ 876
Query: 1480 KEEHVVMEEKTDQPSDSEMMYDSDVPFQIV 1509
++ V E + E + + D Q V
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTV 906
Score = 39.7 bits (91), Expect = 0.035
Identities = 183/972 (18%), Positives = 354/972 (36%), Gaps = 198/972 (20%)
Query: 584 DCDVSLESVVDHPQL--------TV------KGRNLKGRQVHLKHKKRKPSSAKAHLDCD 629
D SLES+ D Q+ TV + L+ + LK K ++ ++ ++ D
Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND 668
Query: 630 VSLGTVADESQRAVEKINLLKE---------KNADLMD--------MNCESHGPEMGFQA 672
+ L E+++ ++ ++L KE K L+D N E G Q
Sbjct: 669 IQLYQSQLEAKKKMQ-VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 673 DAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSD--SPASLYHSAHDEPQEALDEVN 730
+ L + + E R++V + E KS+ S L + + H E + EV
Sbjct: 728 E--LNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 731 LKELNI-----DMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCES 785
KE + ++ D ++++ + S + H+D E K + + E+E
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 786 DSSEIT-----FDSDIPLYSVIDQPEVAVYEEETVDLESKSNE-SCVSEITFDSDIPLHS 839
+ ++ FDS + + +E+T +++ + NE + E + D L +
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 840 GNDHPEVA----------VKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEV 889
+ VK + Q+++ + +++ + ++ SD H ++ ++ E
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 890 AVKKLNPQKEEQVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLE 949
L K+ Q + +++ I EVS N+ TG ++D ++ + + LE
Sbjct: 966 LRNALESLKQHQETINTLKSK-ISEEVSR--NLHMEENTGETKDEFQQKMVGIDKKQDLE 1022
Query: 950 NKSVFETSLDSDVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHY 1009
K+ +L +DV + I + E + E KT L +
Sbjct: 1023 AKNT--QTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080
Query: 1010 SVTEPQVAV--NKINRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVN 1067
+ ++ + +++ ++++ V + KN A KE ++
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNH------------------------AIKKEGELS 1116
Query: 1068 LKDKNSKSGDSKITFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSV 1127
+ K+ S+QLQE +++ +EE+ ++ KINE
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE--------------- 1161
Query: 1128 ADQPKVAIKHVNLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIEL 1187
NL N E+KN + + M E E +EL
Sbjct: 1162 -----------NLKN------ELKNKELTLEHM--------------------ETERLEL 1184
Query: 1188 EGKHNQCCGSEVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDS 1247
K N+ + ++ KE + K+ + E R+ +G+ ++
Sbjct: 1185 AQKLNE----------------NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA 1228
Query: 1248 DVLQPVAGQPEEVVKEVSLWKEHV----DLENKIVKPTDSRINFD----SHEPLQSVTNK 1299
LQ + E + + L KEH +L + + T IN SH LQ
Sbjct: 1229 TGLQT---KEELKIAHIHL-KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ----- 1279
Query: 1300 IPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSS 1359
+EI +L EE L P+ E+ Q + + +L E+ ++ +D ++
Sbjct: 1280 -----EEIPVLHEEQELL------PNVKEV-----SETQETMNELELLTEQ-STTKDSTT 1322
Query: 1360 NSYSPEESSDSNDSFQAAADELQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQ 1419
+ E N+ FQ + +E++ KE + K LE K +L + HI
Sbjct: 1323 LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE-------HIRET 1375
Query: 1420 FVTDQSSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQ 1479
Q S +E +L K+ D E + K L+ E++ +S + +
Sbjct: 1376 LAKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 1480 KEEHVVMEEKTD 1491
E V +EK D
Sbjct: 1435 DEMKSVAKEKDD 1446
Score = 39.7 bits (91), Expect = 0.035
Identities = 150/887 (16%), Positives = 342/887 (38%), Gaps = 115/887 (12%)
Query: 312 KTDMPSNKGIFEDTIAKNHE------EFFSNMDCTQEEKHLVFNKTAFWEQKCSVSSEMK 365
KTD+ N E TI E E + +EK+ K + C +E++
Sbjct: 1070 KTDLKEN---IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 366 FDCISLQSASDQPQETAQDLSLWKEEQIDQE---DNYESRGSEMSFDCSSSFHSLTDQSK 422
L+ S Q QE Q L +EE + + + E+ +E+ + H T++ +
Sbjct: 1127 E---KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE 1183
Query: 423 VSAKEVNLSKEVRTDV-QYKNNKSYVSKISSDCDDILHLVTN------QSQMIVKEISLQ 475
++ K +EV++ + K K ++ D + + Q++ +K +
Sbjct: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH 1243
Query: 476 NARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSS 535
H +D+ S S +T A +T D + + L +E+ + ++ +
Sbjct: 1244 LKEHQETIDELRRSVSEKT-----AQIINTQDLEK---SHTKLQEEIPVLHEEQELLPNV 1295
Query: 536 SEVSA--DSVFPLQSVVDRPPVAVTETKLR-KKAHTSLVDNYGSSCSETSFDCDVSLESV 592
EVS +++ L+ + ++ + T R + L + + S E SL
Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIK-----SLTKE 1350
Query: 593 VDHPQLTVKGRNLKGRQV--HLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLK 650
D+ + + +K Q+ H++ K +++ + +++ +E+ + V ++ K
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
Query: 651 EKNADLMDMNCESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDS 710
K++ L+ + E G Q ++ + ++K D+ Q + L S+S
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQES-----HDEMKSVAKEKDDL-------QRLQEVLQSES 1458
Query: 711 PASLYHSAHDEPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAE 770
D+ +E + E+ K L + E++ C E + ++++E+ +
Sbjct: 1459 ---------DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE-TEIS 1508
Query: 771 GKERHIDLEDESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEIT 830
++ ++ ++ ++ EI + I + + V E + K+ +S + I
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE 1568
Query: 831 ---FDSDIPLHSGNDHPEVAVKE---VIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVT 884
+ L + ++ +KE + + +E + +ER + + EI
Sbjct: 1569 SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI------------ 1616
Query: 885 NSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKE 944
VA K + +KE Q NE + +++ + + ++++L E
Sbjct: 1617 ----VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL--------KEQFETQKLNLENIE 1664
Query: 945 HMYLENKSVFETSLDSDVPLQAATHKPEVI--VKETWLQREKHAEFQGRSTEFSGSKTSL 1002
+ + +L+ +++ T + + + V+ET + R T +
Sbjct: 1665 TENIRLTQILHENLEE---MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721
Query: 1003 DSGVPHYSVTEPQVAVNKIN----------RKKQYVLENKNDKCSGSEIILDSNVPPQSM 1052
+ + H + E Q ++K+ Q LE+ ND ++ + + M
Sbjct: 1722 ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781
Query: 1053 TDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSE--QLQEAVKKIDQWKEEVIGLKNKINE 1110
+ Q + + + +K K + + ++ +LQE ++++ + ++I LK +NE
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841
Query: 1111 PSTYKLIHHPDVSVQSVADQ----PKVAIKHVNLGNENHMYLEVKNS 1153
T K + + + + DQ K+ I+++NL + H LE S
Sbjct: 1842 --TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 48.1 bits (113), Expect = 1e-04
Identities = 38/148 (25%), Positives = 64/148 (43%), Gaps = 12/148 (8%)
Query: 24 SAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQD--------ETHVNTGS 75
S + R +++ R + +S E+ Q++L Q + Q E+ TG
Sbjct: 998 SEEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGE 1057
Query: 76 SSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSRPHKSQEGTQEVSVRP 135
+++ L SEEEEE+ED+ E+E+ EE E E EE + +E Q R
Sbjct: 1058 RGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEE----EEEEEENIQSSPPRL 1113
Query: 136 SVIQKLEKGQQQPLEFVHKIGASVRKCN 163
+ Q + +++P K G R+ N
Sbjct: 1114 TKPQSVAIKRKRPFVLKKKRGRKRRRIN 1141
Score = 31.6 bits (70), Expect = 9.6
Identities = 26/82 (31%), Positives = 39/82 (47%), Gaps = 11/82 (13%)
Query: 63 SSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKV--EDEDATEERPSEVSEPIEELHSR 120
S ++E ++T + LDD EEEEEDE+ ED DA +E S + E
Sbjct: 1387 SQEKEEPEIST-EKEDSARLDD-HEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEEL 1444
Query: 121 PHKS-------QEGTQEVSVRP 135
P +S QE +++V+P
Sbjct: 1445 PRESFKEVLENQETFLDLNVQP 1466
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 47.4 bits (111), Expect = 2e-04
Identities = 118/595 (19%), Positives = 226/595 (37%), Gaps = 60/595 (10%)
Query: 557 VTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKK 616
+ E + K+ H ++ +C+ L+ ++D + +K ++ + K+
Sbjct: 172 ILELEEEKRKHKEYMEKSDEFICLLEQECE-RLKKLID--------QEIKSQEEKEQEKE 222
Query: 617 RKPSSAKAHLDCDVSLGT-VADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQ 675
++ ++ K L S V DE QR ++ L ++K +L E+H A+A+
Sbjct: 223 KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA--LAEAR 280
Query: 676 LADQSQVA-----EIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQ-EALDEV 729
+ ++ Q A E++ Q + ++ + ++ S + A Q + L+E
Sbjct: 281 VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
Query: 730 NLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTE--QSHLDAEGKERHIDLEDESCESDS 787
N + E++ S+ + + + V E + LD EGK+ + +E C +
Sbjct: 341 NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLN 400
Query: 788 SEI---TFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHP 844
+ T S V + + E+ D +KS + C S L +
Sbjct: 401 KRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS---------LKCNLEKE 451
Query: 845 EVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHL 904
+ K++ Q+ E + + K E S + +T + V ++ +K L
Sbjct: 452 RMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 511
Query: 905 ENKEN--EPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENK--SVFETSLDS 960
+ E+ + S++ ++ N VT +E I+E K +E K SV + D
Sbjct: 512 KKTEDKLQAASSQLQVEQN----KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
Query: 961 DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK 1020
L+A K ++ + + + + +F +K + DSG S T NK
Sbjct: 568 KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG---KSTTALHQENNK 624
Query: 1021 INRKKQYVLENKNDKCSGSEIILDSNVPPQ-----------SMTDQPQLAFLKEKHVNLK 1069
I Q V E K + I D + + + D+ Q + +HV ++
Sbjct: 625 IKELSQEV-ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKME 683
Query: 1070 DKNSKSGDSKITFDSE----QLQEAVKKIDQWKEEVIGLKNKINE-PSTYKLIHH 1119
K + T + +LQE K EV LK KI+E +T LI H
Sbjct: 684 LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH 738
Score = 32.0 bits (71), Expect = 7.4
Identities = 43/167 (25%), Positives = 74/167 (44%), Gaps = 34/167 (20%)
Query: 1372 DSFQAAA-----DELQKPVKEINLWKEDHIYLEDKSYK--LGDFDVSYASHIPVQFVTDQ 1424
D+FQA + D +KP+ E++ E H +SY+ LG V+ S
Sbjct: 122 DAFQAKSTPWQEDIYEKPMNELDKVVEKH----KESYRRILGQLLVAEKSRRQT------ 171
Query: 1425 SSVPVKEINLQKKDHNDLENKNCE-VCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEH 1483
+ E+ +K+ H + K+ E +C E +C L+ +DQ S +E + +KE+
Sbjct: 172 ----ILELEEEKRKHKEYMEKSDEFICLLEQECE---RLKKLIDQEIKSQEEKEQEKEKR 224
Query: 1484 V--VMEEKTDQPSDSEMMYDSD--VPFQIV-----VNQFPGSVKETH 1521
V + EE T S + M+ D + Q+ + + + KETH
Sbjct: 225 VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 47.4 bits (111), Expect = 2e-04
Identities = 118/595 (19%), Positives = 226/595 (37%), Gaps = 60/595 (10%)
Query: 557 VTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKK 616
+ E + K+ H ++ +C+ L+ ++D + +K ++ + K+
Sbjct: 172 ILELEEEKRKHKEYMEKSDEFICLLEQECE-RLKKLID--------QEIKSQEEKEQEKE 222
Query: 617 RKPSSAKAHLDCDVSLGT-VADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQ 675
++ ++ K L S V DE QR ++ L ++K +L E+H A+A+
Sbjct: 223 KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA--LAEAR 280
Query: 676 LADQSQVA-----EIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQ-EALDEV 729
+ ++ Q A E++ Q + ++ + ++ S + A Q + L+E
Sbjct: 281 VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
Query: 730 NLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTE--QSHLDAEGKERHIDLEDESCESDS 787
N + E++ S+ + + + V E + LD EGK+ + +E C +
Sbjct: 341 NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLN 400
Query: 788 SEI---TFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHP 844
+ T S V + + E+ D +KS + C S L +
Sbjct: 401 KRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS---------LKCNLEKE 451
Query: 845 EVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHL 904
+ K++ Q+ E + + K E S + +T + V ++ +K L
Sbjct: 452 RMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 511
Query: 905 ENKEN--EPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENK--SVFETSLDS 960
+ E+ + S++ ++ N VT +E I+E K +E K SV + D
Sbjct: 512 KKTEDKLQAASSQLQVEQN----KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
Query: 961 DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK 1020
L+A K ++ + + + + +F +K + DSG S T NK
Sbjct: 568 KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSG---KSTTALHQENNK 624
Query: 1021 INRKKQYVLENKNDKCSGSEIILDSNVPPQ-----------SMTDQPQLAFLKEKHVNLK 1069
I Q V E K + I D + + + D+ Q + +HV ++
Sbjct: 625 IKELSQEV-ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKME 683
Query: 1070 DKNSKSGDSKITFDSE----QLQEAVKKIDQWKEEVIGLKNKINE-PSTYKLIHH 1119
K + T + +LQE K EV LK KI+E +T LI H
Sbjct: 684 LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH 738
Score = 32.0 bits (71), Expect = 7.4
Identities = 43/167 (25%), Positives = 74/167 (44%), Gaps = 34/167 (20%)
Query: 1372 DSFQAAA-----DELQKPVKEINLWKEDHIYLEDKSYK--LGDFDVSYASHIPVQFVTDQ 1424
D+FQA + D +KP+ E++ E H +SY+ LG V+ S
Sbjct: 122 DAFQAKSTPWQEDIYEKPMNELDKVVEKH----KESYRRILGQLLVAEKSRRQT------ 171
Query: 1425 SSVPVKEINLQKKDHNDLENKNCE-VCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEH 1483
+ E+ +K+ H + K+ E +C E +C L+ +DQ S +E + +KE+
Sbjct: 172 ----ILELEEEKRKHKEYMEKSDEFICLLEQECE---RLKKLIDQEIKSQEEKEQEKEKR 224
Query: 1484 V--VMEEKTDQPSDSEMMYDSD--VPFQIV-----VNQFPGSVKETH 1521
V + EE T S + M+ D + Q+ + + + KETH
Sbjct: 225 VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH 271
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 47.4 bits (111), Expect = 2e-04
Identities = 189/1038 (18%), Positives = 383/1038 (36%), Gaps = 184/1038 (17%)
Query: 376 DQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVR 435
D +E A+D+ K E + E + +++ + + + L + K N S +
Sbjct: 650 DTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLI 709
Query: 436 TDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETN 495
+++ N K + Q+Q I + I++ + + ++ + S E
Sbjct: 710 QELETSNKK----------------IITQNQRIKELINIIDQKEDTINEFQNLKSHMENT 753
Query: 496 FDCDASPQSTSDYPQQSVT---EVNLPKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDR 552
F C+ ++S + V +PK+ + + + +E+ D
Sbjct: 754 FKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDE---------- 803
Query: 553 PPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHL 612
PP + H S SE + ++ + D L L+ + +
Sbjct: 804 PPAK------KGSIHVSSAITEDQKKSE---EVRPNIAEIEDIRVLQENNEGLRAFLLTI 854
Query: 613 KHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQA 672
+++ + KA L+ + + EK NL K + N + A
Sbjct: 855 ENELKNEKEEKAELNKQI---VHFQQELSLSEKKNLTLSKEVQQIQSNYDI--------A 903
Query: 673 DAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLK 732
A+L Q + + +K+ + L N+ ++RS ++ S L H+ DE + LD V+ +
Sbjct: 904 IAELHVQKSKNQEQEEKI-MKLSNEIETATRSITNNVSQIKLMHTKIDELR-TLDSVS-Q 960
Query: 733 ELNIDM-EVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHID--LEDESCESDSSE 789
NID+ +R S E D+ P + LD G + + +++ + + E
Sbjct: 961 ISNIDLLNLRDLSNGSEE---DNLP-------NTQLDLLGNDYLVSKQVKEYRIQEPNRE 1010
Query: 790 ITFDSDIPLYSVIDQPEVAVYEE--ETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVA 847
+F S I A++EE E V SK +
Sbjct: 1011 NSFHSSIE----------AIWEECKEIVKASSKKSHQ----------------------- 1037
Query: 848 VKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENK 907
++E+ Q+ E + E K + + + H + E +++L + +E+
Sbjct: 1038 IEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEK------ 1091
Query: 908 ENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVP--LQ 965
V+LD I H V G+ + E++ Y ET L++
Sbjct: 1092 -------NVTLDVQIQ-HVVEGKRA--LSELTQGVT--CYKAKIKELETILETQKVECSH 1139
Query: 966 AATHKPEVIVKETWLQREKH--AEFQGRSTEFSGSKTSLDSGVPHYSVTEP--QVAVNKI 1021
+A + +++ KE+ + + + EFQ + K + D V + E Q+ N
Sbjct: 1140 SAKLEQDILEKESIILKLERNLKEFQEHLQD--SVKNTKDLNVKELKLKEEITQLTNNLQ 1197
Query: 1022 NRKKQYVLENKNDKCSGSEII-LDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKI 1080
+ K L+ + ++ + E L + S Q A L+ K + D K D+K
Sbjct: 1198 DMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAK- 1256
Query: 1081 TFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSV-QSVADQPKVAIKHVN 1139
+Q+++ K++ ++E L+ KINE K ++ + Q Q K +
Sbjct: 1257 ----KQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQL---- 1308
Query: 1140 LGNENHMYLEVKNSQY--SCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGS 1197
N+ +E QY +C ++N+ + I+ ++T+ EQE ++E
Sbjct: 1309 ----NNQKVEEAIQQYERACKDLNVK-----EKIIEDMRMTLEEQEQTQVE--------- 1350
Query: 1198 EVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQP 1257
D L++ + + E+ WK++ D E + N+ E ++DVL +
Sbjct: 1351 -----QDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQ 1405
Query: 1258 EEVVKE------------------VSLWKEHVDLENKIVK--PTDSRINFDSHEPLQSVT 1297
+E+ + ++ KE ++ NK +K D F ++ +T
Sbjct: 1406 DELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILT 1465
Query: 1298 NKIPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDK 1357
++ + ++ REE L + + + SN+ + I+Q + E + +E +
Sbjct: 1466 AQLTEKDSDLQKWREERDQL--VAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQ 1523
Query: 1358 SSNSYSPEESSDSNDSFQ 1375
+ SS D Q
Sbjct: 1524 IMDIKPKRISSADPDKLQ 1541
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 46.6 bits (109), Expect = 3e-04
Identities = 140/744 (18%), Positives = 290/744 (38%), Gaps = 91/744 (12%)
Query: 804 QPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERK 863
+ EV+ Y+E D+E ++ V E+ D+ + L + + + ++ LE++
Sbjct: 326 ESEVSRYKERLHDIEFY--KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 864 NDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNII 923
N + A LH + ++ KK+ EE + LE + + +D +
Sbjct: 384 NLQLK---------AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL------- 427
Query: 924 FHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQRE 983
H+ E + + TS S+ P ++ H+ + L+ E
Sbjct: 428 ---------------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 984 KHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENK--NDKCSGSEI 1041
E Q + +T++DS + S N+ KK +LEN+ +K S
Sbjct: 467 --MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1042 ILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVKKIDQWKEEV 1101
N+ M ++ QL EK + +NS+ + ++E L + V + Q +
Sbjct: 525 ---QNLSKDLMKEKAQL----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ-- 575
Query: 1102 IGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLE----VKNSQYSC 1157
I + ++ + I H + ++ + K+ + + E Y E + +
Sbjct: 576 ISAEARVKDIEKENKILHESIK-ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 1158 SEMNLDSGFLGQSIVNR----PQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADR 1213
+ ++ L + I N +I LEQE+ ELE ++ + + SF +++ +
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF------KNLTFQ 688
Query: 1214 LRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDL 1273
L KE S +E + E RRN + S + + + +E+ E K+ ++L
Sbjct: 689 LESLEKENSQLDEENL--ELRRNVE---SLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 1274 ENKIVKPTDS-RINFDSHE-PLQSVTNKIPGANKEINLLREEHVCLD-DKGYVPSDSEII 1330
K T+ +++ + Q + + +NK+I L E L+ + + + E +
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 1331 YVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEES-------------SDSNDSFQAA 1377
+S+ L+ + K+ LE+E + LE K E ++N
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLE-KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 1378 ADELQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKK 1437
E + KEI ++KE + L++ + + V A+ VT + + +++ Q+
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKEL-VKRATIDIKTLVTLREDLVSEKLKTQQM 921
Query: 1438 DHNDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSE 1497
+NDLE E+ + +H + D + E+ L+ +E K ++ + E
Sbjct: 922 -NNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980
Query: 1498 MMYDSDVPFQIVVNQFPGSVKETH 1521
+ + + Q +VK+ +
Sbjct: 981 ARLEESTNYNQQLRQELKTVKKNY 1004
Score = 39.3 bits (90), Expect = 0.046
Identities = 145/797 (18%), Positives = 302/797 (37%), Gaps = 117/797 (14%)
Query: 638 ESQRAVEKINLLKEKNADLMDMNCE--------SHGPEM---GFQADAQLADQSQVAEIE 686
E +R VE + K A L N E G E+ F+ +L Q +IE
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 687 RQKVDVDLEN--KSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDM---EVR 741
Q++ LEN K +Q S L + Q+ L+E+ + ++ E +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQD------LEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 742 SYDCSSSELTFDSDPPLLSVTEQSHLDAEGKE--RHIDLEDESCESDSSEITFDSDIPLY 799
S + +S+L D + L+ E K + +++D + E ++ +I ++
Sbjct: 819 SLEQETSQLEKD----------KKQLEKENKRLRQQAEIKDTTLEENNVKI---GNLEKE 865
Query: 800 SVIDQPEVAVYEEETVDLES--KSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEY 857
+ E+ +Y+E V L+ K N+ V T D + D V E ++ ++
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED----LVSEKLKTQQM 921
Query: 858 IH-LERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVH--LENKENEPIDS 914
+ LE+ E +I + LH ++ + K L + E + LE KE +
Sbjct: 922 NNDLEKLTHELE--KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979
Query: 915 EVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVI 974
E L+ + T ++ +E+ K + L+ + E + S P+ +K E
Sbjct: 980 EARLEES------TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 975 VKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKND 1034
+ET + K + R E + +L + E Q ++ + LE +N+
Sbjct: 1034 SQETTRELLK---VKDRLIEVERNNATLQA--------EKQALKTQLKQ-----LETQNN 1077
Query: 1035 KCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVKKI 1094
+ L Q+++ Q Q L+ ++ L+ +NS + ++ Q +++
Sbjct: 1078 NLQAQILALQR----QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Query: 1095 DQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLEVKNSQ 1154
E +K + + S Y + + D K+ + H +E + K+
Sbjct: 1134 SLENENESVIKEREDLKSLYDSL---------IKDHEKLELLHERQASEYESLIS-KHGT 1183
Query: 1155 YSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADR- 1213
+ NL E EH +LE ++NQ + + + + V
Sbjct: 1184 LKSAHKNL------------------EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1225
Query: 1214 --LRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHV 1271
L E + +++ E+ R +++ +++VLQ + ++ L + +
Sbjct: 1226 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 1272 DLENKIVKP-------TDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDKGYVP 1324
+ E +K T +++N + E L + + N+ + L + + + L ++ +
Sbjct: 1286 EAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHL-LDQIQTLMLQNRTLLE 1343
Query: 1325 SDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNS---YSPEESSDSNDSFQAAADEL 1381
+ E + ++ + I + + L + LE+K + Y P + +L
Sbjct: 1344 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKL 1403
Query: 1382 QKPVKEINLWKEDHIYL 1398
K K+IN ++ + L
Sbjct: 1404 IKSKKDINRERQKSLTL 1420
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 46.6 bits (109), Expect = 3e-04
Identities = 168/911 (18%), Positives = 351/911 (38%), Gaps = 99/911 (10%)
Query: 626 LDCDVSLGTVADESQRAVEKINL-LKEKNADLMDMNCESHGPEMGFQADAQLADQSQVAE 684
LDC L + S+ ++ +I++ L EK + E E +Q Q Q
Sbjct: 344 LDCQ-QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402
Query: 685 IERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDMEVRSYD 744
E+++ + L+++ Q L ++ H E ++ E K ++ + +V
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLMDKEQQVADLQ 459
Query: 745 CSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLE--DESCESDSSEITFDSDIPLYSVI 802
S L + + TE H + K++H + + +S + E D + L +
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 803 DQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLER 862
D+ + + E + +SK N S + + D + +G E AV +Q++ + E+
Sbjct: 520 DKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG--ETAVLNQLQEKNHTLQEQ 576
Query: 863 KNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQ-VHLENKENEPIDSEVSLDYN 921
+ S+SH + A + L+ Q +EQ HL ++ + E S++
Sbjct: 577 VTQLTEKLKNQSESH----------KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE- 625
Query: 922 IIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQ 981
+S S++ + ++ + K K+ S ++ Q A + + + LQ
Sbjct: 626 --LNSQLNESKEKVSQLDIQIKA------KTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 982 REKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKND------- 1034
+K E +T+ L H S E + K ++K LE K +
Sbjct: 678 -DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL---KEYKEKYLSLEQKTEELEGQIK 733
Query: 1035 ---------KCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSE 1085
K S + + D Q TD A K + ++ + S + SE
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 1086 QLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQ---SVADQPKVAIKHVNLGN 1142
L+ +K+ + +EE LK S I H +++ + +V + KV ++ L
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 1143 ENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVSFD 1202
E ++ K S+ S S N S F ++ + I LE+ EL KH E +
Sbjct: 854 ELST-VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL--KHQLQVQMENTLK 910
Query: 1203 SDDPLQSVADRLRETVKEISL----WKDEEVDTED--RRNEAKGFEIMYDSDVLQPVAGQ 1256
L+ ++ +E ++ L +++ + ++ ++NE + ++ + + L+ + Q
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQ 970
Query: 1257 PEEVVKEVS-----LWKEHVDLENKI---------------VKPTDSRINFD-SHEPLQS 1295
++ ++ + + +LENK+ K + + N++ S E +
Sbjct: 971 KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 1296 VTNKIPGANKEINLLREEHVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLE 1355
+ + G E+ R++ +++K + + I + I Q+ + Q E
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ-----------E 1079
Query: 1356 DKSSNSYSPEESSDSNDSFQAAADELQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASH 1415
K++ + ++S+ Q LQ KE +L +++ + + K ++ +
Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 1416 IPV--QFVTDQSSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHLQ---SEVDQPQ 1470
I + + +KEI K L + E+ G + V + ++ + Q
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQ 1199
Query: 1471 VSYKEADLQKE 1481
V +E +L+KE
Sbjct: 1200 VKKEEEELKKE 1210
Score = 33.5 bits (75), Expect = 2.5
Identities = 106/598 (17%), Positives = 218/598 (36%), Gaps = 89/598 (14%)
Query: 342 EEKHLVFNK-TAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYE 400
++K NK T +Q + + + C L+S + +E L EE Q E
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 401 SRGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRT---DVQYKNNKSYVSKISSDCDDI 457
+ E+ + L Q +++N E+R Q + K VS D
Sbjct: 737 ADSLEVKASKEQALQDLQQQ-----RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 458 LHLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVN 517
+ + Q + K+ ++ Q +E+ S ET + ++ Q +VTE+
Sbjct: 792 SEALESIKQKLTKQ-----EEEKQILKQDFETLSQETKIQ----HEELNNRIQTTVTELQ 842
Query: 518 LPKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSS 577
K ++K + D L V D + +E + + + + + +
Sbjct: 843 KVK------MEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 578 CSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVAD 637
C E V +E+ + Q +K K ++ + K S + + +L
Sbjct: 894 CKELKHQLQVQMENTLKE-QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 638 ESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENK 697
E Q+ IN LK+ + E + L + ++A +++ +++ L+ +
Sbjct: 953 EEQQLQGNINELKQSS-------------EQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 698 SVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPP 757
Q+++ + S+ + +++ QE K+L D R + ++ S
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETF-----KQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 758 LLSVTE------------QSHLDAEGKERHIDLEDESCESDSS---------EITFDSDI 796
LS+ + Q+ L E K LE +S + + +I + +
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 797 PLYSVIDQP-------EVAVYEEETV-----DLESKSNESCVSEITFDSD---------I 835
++++ E+ +E+ + +L+S ES + EIT D +
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES-IKEITNLKDAKQLLIQQKL 1173
Query: 836 PLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKK 893
L D + AV++ + ++ + + K +E + + A LHS EV +KK
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKK 1231
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 46.2 bits (108), Expect = 4e-04
Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%)
Query: 26 QHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQDETHVNTGSSSEVVHLDDA 85
+HR L R + S+L + +Q Q H ++ Q + H+N S + L
Sbjct: 442 RHRPLNRTQSAPLPQSTLAQLVIQ---QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQP 498
Query: 86 FSEEEEEDEDKVEDEDATEER-PSEVSEPIEELHSRPHKS--QEGTQEVSVRP------S 136
S EE +E+ D+ E+R PS + + + + Q G +V P +
Sbjct: 499 GSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDA 558
Query: 137 VIQKLEKGQ-----QQP-LEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASC 190
IQ++E G+ QQP LE H SVR+ L +G + LV + AS
Sbjct: 559 QIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLV-SRTHSSPAASV 617
Query: 191 LPESSNDRPV 200
LP + DRP+
Sbjct: 618 LPHPAMDRPL 627
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 46.2 bits (108), Expect = 4e-04
Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%)
Query: 26 QHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQDETHVNTGSSSEVVHLDDA 85
+HR L R + S+L + +Q Q H ++ Q + H+N S + L
Sbjct: 445 RHRPLNRTQSAPLPQSTLAQLVIQ---QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQP 501
Query: 86 FSEEEEEDEDKVEDEDATEER-PSEVSEPIEELHSRPHKS--QEGTQEVSVRP------S 136
S EE +E+ D+ E+R PS + + + + Q G +V P +
Sbjct: 502 GSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDA 561
Query: 137 VIQKLEKGQ-----QQP-LEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASC 190
IQ++E G+ QQP LE H SVR+ L +G + LV + AS
Sbjct: 562 QIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLV-SRTHSSPAASV 620
Query: 191 LPESSNDRPV 200
LP + DRP+
Sbjct: 621 LPHPAMDRPL 630
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 46.2 bits (108), Expect = 4e-04
Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%)
Query: 26 QHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQDETHVNTGSSSEVVHLDDA 85
+HR L R + S+L + +Q Q H ++ Q + H+N S + L
Sbjct: 442 RHRPLNRTQSAPLPQSTLAQLVIQ---QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQP 498
Query: 86 FSEEEEEDEDKVEDEDATEER-PSEVSEPIEELHSRPHKS--QEGTQEVSVRP------S 136
S EE +E+ D+ E+R PS + + + + Q G +V P +
Sbjct: 499 GSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDA 558
Query: 137 VIQKLEKGQ-----QQP-LEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASC 190
IQ++E G+ QQP LE H SVR+ L +G + LV + AS
Sbjct: 559 QIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLV-SRTHSSPAASV 617
Query: 191 LPESSNDRPV 200
LP + DRP+
Sbjct: 618 LPHPAMDRPL 627
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 46.2 bits (108), Expect = 4e-04
Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 19/190 (10%)
Query: 26 QHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQESSSTQDETHVNTGSSSEVVHLDDA 85
+HR L R + S+L + +Q Q H ++ Q + H+N S + L
Sbjct: 442 RHRPLNRTQSAPLPQSTLAQLVIQ---QQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQP 498
Query: 86 FSEEEEEDEDKVEDEDATEER-PSEVSEPIEELHSRPHKS--QEGTQEVSVRP------S 136
S EE +E+ D+ E+R PS + + + + Q G +V P +
Sbjct: 499 GSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDA 558
Query: 137 VIQKLEKGQ-----QQP-LEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASC 190
IQ++E G+ QQP LE H SVR+ L +G + LV + AS
Sbjct: 559 QIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLV-SRTHSSPAASV 617
Query: 191 LPESSNDRPV 200
LP + DRP+
Sbjct: 618 LPHPAMDRPL 627
>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
Length = 860
Score = 45.8 bits (107), Expect = 5e-04
Identities = 55/276 (19%), Positives = 108/276 (39%), Gaps = 29/276 (10%)
Query: 679 QSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDM 738
+ ++AE + + V D++ S+ + +SDS P++ ++ +E
Sbjct: 107 RKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKKKKKLRQREEKSPD 166
Query: 739 EVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEITFDSDIPL 798
+++ + +L S P L S E D K+R + ++E ES + +
Sbjct: 167 DLKKKKAKAGKLKDKSKPDLESSLESLVFDLRTKKRISEAKEELKESKKPKKDEVKETKE 226
Query: 799 YSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYI 858
+ + E+ DL++K+ E P + E V+ ++ E +
Sbjct: 227 LKKVKKGEIR-------DLKTKTRED-----------PKENRKTKKEKFVESQVESESSV 268
Query: 859 HLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSL 918
ND P D LHS + + K + + + LE+ +P+DS +S
Sbjct: 269 ----LNDSP----FPEDDSEGLHSDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSA 320
Query: 919 DYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVF 954
+ + V GR + + T+E+ LENK+ F
Sbjct: 321 EEDT---DVRGRRKKKTPRKAEDTRENRKLENKNAF 353
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 45.4 bits (106), Expect = 6e-04
Identities = 107/516 (20%), Positives = 195/516 (37%), Gaps = 50/516 (9%)
Query: 635 VADESQRAVEKINLLKEKNADLMDMNCESHGPEMGFQADAQLADQSQVA-----EIERQK 689
V DE QR ++ L ++K +L E+H A+A++ ++ Q A E++ Q
Sbjct: 2 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA--LAEARVQEEEQKATRLEKELQTQT 59
Query: 690 VDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQ-EALDEVNLKELNIDMEVRSYDCSSS 748
+ ++ + ++ S + A Q + L+E N + E++ S
Sbjct: 60 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 119
Query: 749 ELTFDSDPPLLSVTE--QSHLDAEGKERHIDLEDESCESDSSEI---TFDSDIPLYSVID 803
+ + + + V E + LD EGK+ + +E C + + T S V
Sbjct: 120 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK 179
Query: 804 QPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERK 863
+ + E+ D +KS + C S L + + K++ Q+ E + + K
Sbjct: 180 LSKRIMALEKLEDAFNKSKQECYS---------LKCNLEKERMTTKQLSQELESLKVRIK 230
Query: 864 NDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKEN--EPIDSEVSLDYN 921
E S + +T + V ++ +K L+ E+ + S++ ++ N
Sbjct: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
Query: 922 IIFHSVTGRSEDPIKEISLHTKEHMYLENK--SVFETSLDSDVPLQAATHKPEVIVKETW 979
VT +E I+E K +E K SV + D L+A K ++
Sbjct: 291 ----KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 346
Query: 980 LQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSGS 1039
+ + + + +F +K + DSG S T NKI Q V E K
Sbjct: 347 MLKNRLQSLEAIEKDFLKNKLNQDSG---KSTTALHQENNKIKELSQEV-ERLKLKLKDM 402
Query: 1040 EIILDSNVPPQ-----------SMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSE--- 1085
+ I D + + + D+ Q + +HV ++ K + T +
Sbjct: 403 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 462
Query: 1086 -QLQEAVKKIDQWKEEVIGLKNKINE-PSTYKLIHH 1119
+LQE K EV LK KI+E +T LI H
Sbjct: 463 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH 498
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 45.1 bits (105), Expect = 8e-04
Identities = 49/213 (23%), Positives = 80/213 (37%), Gaps = 35/213 (16%)
Query: 71 VNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSRPHKSQEGTQE 130
V EV +++ ++++E+DED E E+ EE E +E + + + E +E
Sbjct: 226 VEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEE 285
Query: 131 VSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRPPVICNAPASC 190
V VR ++ E G + + + KC G NR+N + C
Sbjct: 286 V-VREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNF-------DTEEYC 337
Query: 191 LPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVPSSHVETTSFS 250
+ + P TA +T P+ V+KYLE P E
Sbjct: 338 MAVCGSAIPTTAAST---------------PDAVDKYLETPGD-----------ENEHAH 371
Query: 251 YQKHKES-NRKSLRMNSDKLVLWKDVKSQGKTL 282
+QK KE K S + W++ + Q K L
Sbjct: 372 FQKAKERLEAKHRERMSQVMREWEEAERQAKNL 404
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 44.7 bits (104), Expect = 0.001
Identities = 100/473 (21%), Positives = 181/473 (38%), Gaps = 90/473 (19%)
Query: 221 PNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGK 280
P+ K + P +S P P+ H+ T S ++ E K+ + S L + K++
Sbjct: 44 PSNPRKSVSSPT-SSNTPTPTKHLRTPSTKPKQENEGGEKAA-LESQVRELLAEAKAKDS 101
Query: 281 TLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTDM-PSNKGIFEDTIAKNHEEFFSNMDC 339
++ ++ K +L + L N + T + P + + + ++ F +
Sbjct: 102 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 161
Query: 340 TQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNY 399
+EE ++ K + E S +SE A+ +++ S I QE ++
Sbjct: 162 LEEENRVLKEKLIYLEH--SPNSE---------GAASHTGDSSCPTS------ITQESSF 204
Query: 400 ES-RGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDIL 458
S G++MS D + + + S +DV + +S D D
Sbjct: 205 GSPTGNQMSSDIDEY------KKNIHGNALRTSGSSSSDVTK-------ASLSPDASDFE 251
Query: 459 HLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNL 518
H+ +R +S ++SS T +SP S S+ S+TE
Sbjct: 252 HITAETP-----------SRPLSSTSNPFKSSKCST---AGSSPNSVSELSLASLTE--- 294
Query: 519 PKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSC 578
I +++N+ S++ E+ A LQ + D+ + T +K LVD +
Sbjct: 295 ----KIQKMEENHHSTAEELQAT----LQELSDQQQMVQELTAENEK----LVDE--KTI 340
Query: 579 SETSF--------DCDVSLESVVDHPQLTVKGRN---LKGRQVHLKHK-----------K 616
ETSF E +++ Q VK +G+ + L+ K +
Sbjct: 341 LETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER 400
Query: 617 RKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMD-MNCESHGPEM 668
K + + L C SL V +E+Q A+E I LKE+N L + + E H M
Sbjct: 401 EKLLNIQQQLTC--SLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 44.7 bits (104), Expect = 0.001
Identities = 100/473 (21%), Positives = 181/473 (38%), Gaps = 90/473 (19%)
Query: 221 PNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGK 280
P+ K + P +S P P+ H+ T S ++ E K+ + S L + K++
Sbjct: 44 PSNPRKSVSSPT-SSNTPTPTKHLRTPSTKPKQENEGGEKAA-LESQVRELLAEAKAKDS 101
Query: 281 TLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTDM-PSNKGIFEDTIAKNHEEFFSNMDC 339
++ ++ K +L + L N + T + P + + + ++ F +
Sbjct: 102 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 161
Query: 340 TQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNY 399
+EE ++ K + E S +SE A+ +++ S I QE ++
Sbjct: 162 LEEENRVLKEKLIYLEH--SPNSE---------GAASHTGDSSCPTS------ITQESSF 204
Query: 400 ES-RGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDIL 458
S G++MS D + + + S +DV + +S D D
Sbjct: 205 GSPTGNQMSSDIDEY------KKNIHGNALRTSGSSSSDVTK-------ASLSPDASDFE 251
Query: 459 HLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNL 518
H+ +R +S ++SS T +SP S S+ S+TE
Sbjct: 252 HITAETP-----------SRPLSSTSNPFKSSKCST---AGSSPNSVSELSLASLTE--- 294
Query: 519 PKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSC 578
I +++N+ S++ E+ A LQ + D+ + T +K LVD +
Sbjct: 295 ----KIQKMEENHHSTAEELQAT----LQELSDQQQMVQELTAENEK----LVDE--KTI 340
Query: 579 SETSF--------DCDVSLESVVDHPQLTVKGRN---LKGRQVHLKHK-----------K 616
ETSF E +++ Q VK +G+ + L+ K +
Sbjct: 341 LETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER 400
Query: 617 RKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMD-MNCESHGPEM 668
K + + L C SL V +E+Q A+E I LKE+N L + + E H M
Sbjct: 401 EKLLNIQQQLTC--SLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 451
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 44.7 bits (104), Expect = 0.001
Identities = 100/473 (21%), Positives = 181/473 (38%), Gaps = 90/473 (19%)
Query: 221 PNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGK 280
P+ K + P +S P P+ H+ T S ++ E K+ + S L + K++
Sbjct: 125 PSNPRKSVSSPT-SSNTPTPTKHLRTPSTKPKQENEGGEKAA-LESQVRELLAEAKAKDS 182
Query: 281 TLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTDM-PSNKGIFEDTIAKNHEEFFSNMDC 339
++ ++ K +L + L N + T + P + + + ++ F +
Sbjct: 183 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 242
Query: 340 TQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNY 399
+EE ++ K + E S +SE A+ +++ S I QE ++
Sbjct: 243 LEEENRVLKEKLIYLEH--SPNSE---------GAASHTGDSSCPTS------ITQESSF 285
Query: 400 ES-RGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDIL 458
S G++MS D + + + S +DV + +S D D
Sbjct: 286 GSPTGNQMSSDIDEY------KKNIHGNALRTSGSSSSDVTK-------ASLSPDASDFE 332
Query: 459 HLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNL 518
H+ +R +S ++SS T +SP S S+ S+TE
Sbjct: 333 HITAETP-----------SRPLSSTSNPFKSSKCST---AGSSPNSVSELSLASLTE--- 375
Query: 519 PKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSC 578
I +++N+ S++ E+ A LQ + D+ + T +K LVD +
Sbjct: 376 ----KIQKMEENHHSTAEELQAT----LQELSDQQQMVQELTAENEK----LVDE--KTI 421
Query: 579 SETSF--------DCDVSLESVVDHPQLTVKGRN---LKGRQVHLKHK-----------K 616
ETSF E +++ Q VK +G+ + L+ K +
Sbjct: 422 LETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER 481
Query: 617 RKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMD-MNCESHGPEM 668
K + + L C SL V +E+Q A+E I LKE+N L + + E H M
Sbjct: 482 EKLLNIQQQLTC--SLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
>gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
Length = 790
Score = 44.7 bits (104), Expect = 0.001
Identities = 100/473 (21%), Positives = 181/473 (38%), Gaps = 90/473 (19%)
Query: 221 PNKVEKYLEQPDGASRNPVPSSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGK 280
P+ K + P +S P P+ H+ T S ++ E K+ + S L + K++
Sbjct: 125 PSNPRKSVSSPT-SSNTPTPTKHLRTPSTKPKQENEGGEKAA-LESQVRELLAEAKAKDS 182
Query: 281 TLSAGLKFHERMGTKGSLRVKSPSKLAVNPNKTDM-PSNKGIFEDTIAKNHEEFFSNMDC 339
++ ++ K +L + L N + T + P + + + ++ F +
Sbjct: 183 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 242
Query: 340 TQEEKHLVFNKTAFWEQKCSVSSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNY 399
+EE ++ K + E S +SE A+ +++ S I QE ++
Sbjct: 243 LEEENRVLKEKLIYLEH--SPNSE---------GAASHTGDSSCPTS------ITQESSF 285
Query: 400 ES-RGSEMSFDCSSSFHSLTDQSKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDIL 458
S G++MS D + + + S +DV + +S D D
Sbjct: 286 GSPTGNQMSSDIDEY------KKNIHGNALRTSGSSSSDVTK-------ASLSPDASDFE 332
Query: 459 HLVTNQSQMIVKEISLQNARHISLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNL 518
H+ +R +S ++SS T +SP S S+ S+TE
Sbjct: 333 HITAETP-----------SRPLSSTSNPFKSSKCST---AGSSPNSVSELSLASLTE--- 375
Query: 519 PKEVHIGLVDKNYGSSSSEVSADSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSC 578
I +++N+ S++ E+ A LQ + D+ + T +K LVD +
Sbjct: 376 ----KIQKMEENHHSTAEELQAT----LQELSDQQQMVQELTAENEK----LVDE--KTI 421
Query: 579 SETSF--------DCDVSLESVVDHPQLTVKGRN---LKGRQVHLKHK-----------K 616
ETSF E +++ Q VK +G+ + L+ K +
Sbjct: 422 LETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER 481
Query: 617 RKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMD-MNCESHGPEM 668
K + + L C SL V +E+Q A+E I LKE+N L + + E H M
Sbjct: 482 EKLLNIQQQLTC--SLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 43.9 bits (102), Expect = 0.002
Identities = 144/774 (18%), Positives = 292/774 (37%), Gaps = 120/774 (15%)
Query: 804 QPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEYIHLERK 863
+ EV+ Y+E D+E ++ V E+ D+ + L + + + ++ LE++
Sbjct: 326 ESEVSRYKERLHDIEFY--KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 864 NDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVHLENKENEPIDSEVSLDYNII 923
N + A LH + ++ KK+ EE + LE + + +D +
Sbjct: 384 NLQLK---------AKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL------- 427
Query: 924 FHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVIVKETWLQRE 983
H+ E + + TS S+ P ++ H+ + L+ E
Sbjct: 428 ---------------------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 984 KHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENK--NDKCSGSEI 1041
E Q + +T++DS + S N+ KK +LEN+ +K S
Sbjct: 467 --MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1042 ILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVKKIDQWKEEV 1101
N+ M ++ QL EK + +NS+ + ++E L + V + Q +
Sbjct: 525 ---QNLSKDLMKEKAQL----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ-- 575
Query: 1102 IGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLE----VKNSQYSC 1157
I + ++ + I H + ++ + K+ + + E Y E + +
Sbjct: 576 ISAEARVKDIEKENKILHESIK-ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
Query: 1158 SEMNLDSGFLGQSIVNR----PQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADR 1213
+ ++ L + I N +I LEQE+ ELE ++ + + SF +++ +
Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSF------KNLTFQ 688
Query: 1214 LRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHVDL 1273
L KE S +E + E RRN + S + + + +E+ E K+ ++L
Sbjct: 689 LESLEKENSQLDEENL--ELRRNVE---SLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
Query: 1274 ENKIVKPTDS-RINFDSHE-PLQSVTNKIPGANKEINLLREEHVCLD-DKGYVPSDSEII 1330
K T+ +++ + Q + + +NK+I L E L+ + + + E +
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 1331 YVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEES-------------SDSNDSFQAA 1377
+S+ L+ + K+ LE+E + LE K E ++N
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLE-KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 1378 ADELQKPVKEINLWKEDHIYLED------KSYKLGDFDVSYASHIPVQFVTDQSSVPVKE 1431
E + KEI ++KE + L++ + K D+ + V+++
Sbjct: 863 EKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN 922
Query: 1432 INLQKKDH-------------NDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADL 1478
+L+K H +D ++ + E K S + E+ + +++ EA L
Sbjct: 923 NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 1479 QKEEHVVME------------EKTDQPSDSEMMYDSDVPFQIVVNQFPGSVKET 1520
++ + + E Q D E M S P N++ +ET
Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1036
Score = 35.8 bits (81), Expect = 0.51
Identities = 146/797 (18%), Positives = 301/797 (37%), Gaps = 118/797 (14%)
Query: 638 ESQRAVEKINLLKEKNADLMDMNCE--------SHGPEM---GFQADAQLADQSQVAEIE 686
E +R VE + K A L N E G E+ F+ +L Q +IE
Sbjct: 705 ELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 687 RQKVDVDLEN--KSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDM---EVR 741
Q++ LEN K +Q S L + Q+ L+E+ + ++ E +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQD------LEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 742 SYDCSSSELTFDSDPPLLSVTEQSHLDAEGKE--RHIDLEDESCESDSSEITFDSDIPLY 799
S + +S+L D + L+ E K + +++D + E ++ +I ++
Sbjct: 819 SLEQETSQLEKD----------KKQLEKENKRLRQQAEIKDTTLEENNVKI---GNLEKE 865
Query: 800 SVIDQPEVAVYEEETVDLES--KSNESCVSEITFDSDIPLHSGNDHPEVAVKEVIQKEEY 857
+ E+ +Y+E V L+ K N+ V T D + D V E ++ ++
Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED----LVSEKLKTQQM 921
Query: 858 IH-LERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEEQVH--LENKENEPIDS 914
+ LE+ E +I + LH S + K L + E + LE KE +
Sbjct: 922 NNDLEKLTHELE--KIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKSLEIKEEKIAAL 978
Query: 915 EVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDSDVPLQAATHKPEVI 974
E L+ + T ++ +E+ K + L+ + E + S P+ +K E
Sbjct: 979 EARLEES------TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032
Query: 975 VKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKND 1034
+ET + K + R E + +L + E Q ++ + LE +N+
Sbjct: 1033 SQETTRELLK---VKDRLIEVERNNATLQA--------EKQALKTQLKQ-----LETQNN 1076
Query: 1035 KCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKITFDSEQLQEAVKKI 1094
+ L Q+++ Q Q L+ ++ L+ +NS + ++ Q +++
Sbjct: 1077 NLQAQILALQR----QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1132
Query: 1095 DQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNENHMYLEVKNSQ 1154
E +K + + S Y + + D K+ + H +E + K+
Sbjct: 1133 SLENENESVIKEREDLKSLYDSL---------IKDHEKLELLHERQASEYESLIS-KHGT 1182
Query: 1155 YSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVSFDSDDPLQSVADR- 1213
+ NL E EH +LE ++NQ + + + + V
Sbjct: 1183 LKSAHKNL------------------EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
Query: 1214 --LRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEVVKEVSLWKEHV 1271
L E + +++ E+ R +++ +++VLQ + ++ L + +
Sbjct: 1225 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1284
Query: 1272 DLENKIVKP-------TDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDKGYVP 1324
+ E +K T +++N + E L + + N+ + L + + + L ++ +
Sbjct: 1285 EAEFSKLKEQYQQLDITSTKLN-NQCELLSQLKGNLEEENRHL-LDQIQTLMLQNRTLLE 1342
Query: 1325 SDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNS---YSPEESSDSNDSFQAAADEL 1381
+ E + ++ + I + + L + LE+K + Y P + +L
Sbjct: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKL 1402
Query: 1382 QKPVKEINLWKEDHIYL 1398
K K+IN ++ + L
Sbjct: 1403 IKSKKDINRERQKSLTL 1419
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 43.9 bits (102), Expect = 0.002
Identities = 120/546 (21%), Positives = 205/546 (37%), Gaps = 124/546 (22%)
Query: 575 GSSCSETSFDCDVSLESVVDHPQLTVKGRNLKGRQVHLKHKKRKPSSAKAHLDC---DVS 631
G++ + S C+ +LES H + + H P D V+
Sbjct: 498 GTNNNSQSSSCNGALESTARHDEES--------------HSLSPPGENTVMADSFQIKVN 543
Query: 632 LGTV-ADESQRAVEKINLLKEK-NADLMDMNCESHG-PEMGFQADAQLADQSQVAEIERQ 688
L TV A E E I L K N+DL+D S ++ + + + ++ E +
Sbjct: 544 LMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAFNKVPSPHETKPDEDAEAFENHAE 603
Query: 689 KVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQEALDEVNLKELNIDMEVRSYDCSSS 748
K L +S++S+ DSP EPQ +D+ E + D + C S+
Sbjct: 604 K----LGKRSIKSAHKK--KDSP---------EPQVKMDK---HEPHQDSGEEAEGCPSA 645
Query: 749 --ELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEITFD-SDIPLYSVIDQP 805
E D P + H A+ K E+E + D + + S P S +
Sbjct: 646 PEETPVDKKPEV-------HEKAKRKSTRPHYEEEGEDDDLQGVGEELSSSPPSSCVSLE 698
Query: 806 EVAVYEEETVDLESKSNESCVSEITFDS------DIPL----HSGNDHPEVAVKEVIQKE 855
+ + EE +D + S VS I D ++PL + + PE E + E
Sbjct: 699 TLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDLKNEEMDLE 758
Query: 856 E---YI-HLERKNDEPSGSEISSDSHAPLHS---------------VTNSPEVAVKKLNP 896
E Y+ L+ + +E GS+ SS S P S V +P L P
Sbjct: 759 EPEGYMPDLDSREEEADGSQSSSSSSVPGESLPSASDQVLYLSRGGVGTTPASEPAPLAP 818
Query: 897 QKEEQVHLENKENEPIDSEVS------------LDYNIIFHSVTGRSEDPIKEISLHTKE 944
++ Q E KEN+P+DS S L+ N+ S++ + ++ K + H +
Sbjct: 819 HEDHQQR-ETKENDPMDSHQSQESPNLENIANPLEENVTKESISSKKKEKRKHVD-HVES 876
Query: 945 HMYLENKSV------FETSLDSDVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGS 998
+++ SV E S D +P + + + +L+R H RS+E
Sbjct: 877 SLFVAPGSVQSSDDLEEDSSDYSIPSRTSHSDSSI-----YLRRHTH-----RSSESD-- 924
Query: 999 KTSLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSGSEIILDSNVPPQ----SMTD 1054
H+S + + A + +R+ + + N SG + L S+ P +
Sbjct: 925 ---------HFSYVQLRNAADLDDRRNRILTRKANS--SGEAMSLGSHSPQSDSLTQLVQ 973
Query: 1055 QPQLAF 1060
QP + +
Sbjct: 974 QPDMMY 979
>gi|39545580 cereblon [Homo sapiens]
Length = 442
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 20/102 (19%)
Query: 66 QDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEV--------------S 111
QD H N G+ HL +E EEEDE +VED+D+ E + +
Sbjct: 8 QDAAH-NMGN-----HLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLG 61
Query: 112 EPIEELHSRPHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVH 153
+EE H R + Q + V P V+ L GQ PL+ H
Sbjct: 62 ADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFH 103
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 42.4 bits (98), Expect = 0.005
Identities = 83/418 (19%), Positives = 149/418 (35%), Gaps = 52/418 (12%)
Query: 1085 EQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNLGNEN 1144
E E K + + EE+ L+NK ++S+Q D + + L EN
Sbjct: 1187 EYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSREN 1246
Query: 1145 H-----------MYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQ 1193
L+ + E L G I+ + Q H+E+E K
Sbjct: 1247 RDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQ-------HLEIELKQVM 1299
Query: 1194 CCGSEVSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPV 1253
SE + L+ A +++ KEI K E + RR E Y++++ +
Sbjct: 1300 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE-------YENELSKVR 1352
Query: 1254 AGQPEEVVKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREE 1313
EE++ K + E I K T ++ E +I +E L EE
Sbjct: 1353 NNYDEEIIS----LKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEE 1408
Query: 1314 HVCLDDKGYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDS 1373
L + +++ +I Q ++ +E + EES S
Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468
Query: 1374 FQAAADELQKPVKEINLWKE-------DHIYLEDKSYKLG--DFDVSYASHIPVQFVTDQ 1424
AA +Q KEI K+ D LED++ +L +D+ A+ + + ++
Sbjct: 1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETI-NK 1527
Query: 1425 SSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEE 1482
V +E+ + D+ + + +K ++ + Q S KE LQK++
Sbjct: 1528 LKVQEQELTRLRIDYERVSQER------TVK-------DQDITRFQNSLKELQLQKQK 1572
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 42.4 bits (98), Expect = 0.005
Identities = 98/508 (19%), Positives = 199/508 (39%), Gaps = 57/508 (11%)
Query: 613 KHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMNC--------ESH 664
K K+ + HL + D+ ++ EK +LLK++N + + + +
Sbjct: 246 KFKQHEEYIRNLHLQMEEERTRFKDQQEK--EKNSLLKQQNNAAVKIQAKYKAFVAYQKY 303
Query: 665 GPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHDEPQE 724
GP + Q +++ + E E + + EN+ + + +E ++
Sbjct: 304 GPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKKQ-----KEEERK 358
Query: 725 ALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCE 784
++ ++ NI + R S ++ D + + + +H+ LED S
Sbjct: 359 RREKEYEEKKNIVKQEREQLISKEKIILREDASQQLIISSALKKSGYNNKHLSLEDIS-- 416
Query: 785 SDSSEITFD---------SDIPLYSVIDQPEVAVYEEETVDLES---KSNESCVSEITFD 832
+D +I + D+ L+ V + + +T+ ES K ES +S T
Sbjct: 417 NDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKES-ISSQTIL 475
Query: 833 SDIPLHSGNDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVK 892
+D + N++ +A K EE + ERK + +S + P +K
Sbjct: 476 ADFKMEEKNEN--LAKKRC--SEELVKQERKYENTDNKTELGNSDLKGNLKEQFPLQELK 531
Query: 893 KLNPQKEEQV--HLENKENEPIDSEVSLDYNIIFHSVTGRSEDPI------KEISLHTKE 944
+ QKEE++ H+ N EN +++ L +N V E I K+I KE
Sbjct: 532 S-DAQKEEKIMKHVIN-ENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKE 589
Query: 945 HMYLENKSVFETSLDSDVPLQ----AATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKT 1000
+ +N +++ + ++ + T + V+E + +EK + + E +
Sbjct: 590 EIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKEIEENPKDN 649
Query: 1001 SLDSGVPHYSVTEPQVAVNKINRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAF 1060
+ +SG+ ++ T+ + + + YVL ++ C G SN +S ++
Sbjct: 650 AWNSGIVIFNTTDTMINIEGKRNDQDYVL-GRHAPCEGL-----SNYNAESSMVSKEVNS 703
Query: 1061 LKEKHVNLKDK---NSKSGDSKITFDSE 1085
LK + N+ +K N+ DS SE
Sbjct: 704 LKSEIRNISEKCHENAPEPDSMTCCVSE 731
Score = 36.6 bits (83), Expect = 0.30
Identities = 150/817 (18%), Positives = 302/817 (36%), Gaps = 166/817 (20%)
Query: 748 SELTFDSDPPLLSVTEQSHLDAEGKERHIDLEDESCESDSSEITFDSDIPLYSVIDQPEV 807
+E+ + D +S E+ ++++ K + + + ++DS E+ +S + ++I
Sbjct: 10 AEIEAELDKLSISSLEKEDIESDAKS---ETQSDDSDTDSVELP-ESVLHCINIIKNRSK 65
Query: 808 AVYEEETVDLESKSNESCVSEITFDSDIPLHSG-------NDHPEVAVKEVIQKEEYIHL 860
AV E DLE SC ++ + L +G + + + I+KEE+ +
Sbjct: 66 AVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTEYEESSEQLIKILSEIEKEEF--M 123
Query: 861 ERKND--------EPSGSEISSDSHA-PLHSVTNSPEVAVKKLNPQ-----KEEQVHLEN 906
K D EPS ++ D H P + N V++ Q +E+Q LE+
Sbjct: 124 RSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGYCEVEEKCRQSFEAWQEKQKELED 183
Query: 907 KENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDS-----D 961
KE + + ++ R E +E K H +++ V + L++
Sbjct: 184 KEKQTLKAQ------------RDREEKQFQEEE--EKRHCWMKQFKVEKKKLENIQKQEQ 229
Query: 962 VPLQAATHKPEVIVKETWLQREK-----HAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQV 1016
+ +K E I KE + Q E+ H + + T F +
Sbjct: 230 DKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQ----------------- 272
Query: 1017 AVNKINRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSG 1076
++K +L+ +N+ A +K + K K +
Sbjct: 273 -----EKEKNSLLKQQNN------------------------AAVK---IQAKYKAFVAY 300
Query: 1077 DSKITFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIK 1136
EQ++ +K +WKE+ ++ K E K + Q + ++ K +
Sbjct: 301 QKYGPIIKEQIESKKRKAQEWKEKEAKIRQK--EEENRKRLEEE----QRIKEERKKQKE 354
Query: 1137 HVNLGNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQIT--ILEQEHIELEGKHNQC 1194
E Y E KN E + + I+ R + ++ ++ G +N+
Sbjct: 355 EERKRREKE-YEEKKNIVKQEREQLISK----EKIILREDASQQLIISSALKKSGYNNKH 409
Query: 1195 CGSE-VSFDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPV 1253
E +S D D +++ D + +++ LW EE + ++ + + + + +
Sbjct: 410 LSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESI 469
Query: 1254 AGQ--------------------PEEVVKEVSLWKEHVDLENKI-VKPTDSRINFDSHEP 1292
+ Q EE+VK+ +++ + +NK + +D + N P
Sbjct: 470 SSQTILADFKMEEKNENLAKKRCSEELVKQE---RKYENTDNKTELGNSDLKGNLKEQFP 526
Query: 1293 LQSVTNKIPGANKEINLLREEHVCLDDKG-----YVPSDSEIIYVSNIPLQSVIK---QP 1344
LQ + + A KE +++ HV ++ G + + EI V Q +IK Q
Sbjct: 527 LQELKS---DAQKEEKIMK--HVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQK 581
Query: 1345 HILEEEHASLEDKSSNSYSPEES--SDSNDSFQAAADELQKPVKEINLWKEDHIYLEDKS 1402
I + E +++++ Y +++ + E K V+E + +E IY + K
Sbjct: 582 KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDVRENVILQEKEIYSKSKE 641
Query: 1403 YKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHNDLENKNCEVCGSEIKCHSCVHL 1462
+ D ++ S I + TD IN++ K N V G C +
Sbjct: 642 IEENPKDNAWNSGIVIFNTTDTM------INIEGK-----RNDQDYVLGRHAPCEGLSNY 690
Query: 1463 QSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMM 1499
+E VS + L+ E + E+ + + + M
Sbjct: 691 NAE--SSMVSKEVNSLKSEIRNISEKCHENAPEPDSM 725
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,046,929
Number of Sequences: 37866
Number of extensions: 4503117
Number of successful extensions: 22216
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 330
Number of HSP's that attempted gapping in prelim test: 18494
Number of HSP's gapped (non-prelim): 2587
length of query: 2354
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2235
effective length of database: 13,741,464
effective search space: 30712172040
effective search space used: 30712172040
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.