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Search of human proteins with 150170672
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
(1657 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 3598 0.0
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 1766 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 169 2e-41
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 149 2e-35
gi|134031945 SCO-spondin [Homo sapiens] 138 4e-32
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 129 2e-29
gi|118572606 hemicentin 1 [Homo sapiens] 113 1e-24
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 101 7e-21
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 100 1e-20
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 100 1e-20
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 100 1e-20
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 100 2e-20
gi|147904700 semaphorin 5A [Homo sapiens] 97 1e-19
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 97 2e-19
gi|4505737 complement factor properdin precursor [Homo sapiens] 92 3e-18
gi|223671861 complement factor properdin precursor [Homo sapiens] 92 3e-18
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 89 5e-17
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 87 2e-16
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 85 5e-16
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 85 7e-16
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 84 9e-16
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 84 1e-15
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 79 5e-14
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 78 6e-14
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 78 6e-14
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 78 6e-14
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 75 4e-13
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 75 4e-13
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 75 7e-13
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 71 8e-12
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 3598 bits (9331), Expect = 0.0
Identities = 1657/1657 (100%), Positives = 1657/1657 (100%)
Query: 1 MGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL 60
MGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
Sbjct: 1 MGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL 60
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE 120
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE
Sbjct: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE 120
Query: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK
Sbjct: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
Query: 181 PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV 240
PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
Sbjct: 181 PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV 240
Query: 241 CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI 300
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI
Sbjct: 241 CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI 300
Query: 301 KKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKE 360
KKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKE
Sbjct: 301 KKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKE 360
Query: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV 420
CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
Sbjct: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV 420
Query: 421 PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTH 480
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTH
Sbjct: 421 PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTH 480
Query: 481 KNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL 540
KNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL
Sbjct: 481 KNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL 540
Query: 541 RKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE 600
RKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
Sbjct: 541 RKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE 600
Query: 601 VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQI 660
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQI
Sbjct: 601 VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQI 660
Query: 661 RARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTT 720
RARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTT
Sbjct: 661 RARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTT 720
Query: 721 TWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW 780
TWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
Sbjct: 721 TWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW 780
Query: 781 TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKW 840
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKW
Sbjct: 781 TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKW 840
Query: 841 RRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQ 900
RRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQ
Sbjct: 841 RRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQ 900
Query: 901 IPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK 960
IPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
Sbjct: 901 IPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK 960
Query: 961 YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNS 1020
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNS
Sbjct: 961 YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNS 1020
Query: 1021 HGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVN 1080
HGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVN
Sbjct: 1021 HGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVN 1080
Query: 1081 QAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH 1140
QAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
Sbjct: 1081 QAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH 1140
Query: 1141 VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADE 1200
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADE
Sbjct: 1141 VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADE 1200
Query: 1201 GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD 1260
GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD
Sbjct: 1201 GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD 1260
Query: 1261 LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG 1320
LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG
Sbjct: 1261 LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG 1320
Query: 1321 DGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFS 1380
DGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFS
Sbjct: 1321 DGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFS 1380
Query: 1381 KVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG 1440
KVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG
Sbjct: 1381 KVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG 1440
Query: 1441 IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGIN 1500
IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGIN
Sbjct: 1441 IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGIN 1500
Query: 1501 VTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVV 1560
VTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVV
Sbjct: 1501 VTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSSNSTLEQCTLIPVVV 1560
Query: 1561 LPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLI 1620
LPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLI
Sbjct: 1561 LPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLKTWVYGVAAGAFVLLI 1620
Query: 1621 FIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM 1657
FIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM
Sbjct: 1621 FIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM 1657
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 1766 bits (4574), Expect = 0.0
Identities = 815/1612 (50%), Positives = 1072/1612 (66%), Gaps = 46/1612 (2%)
Query: 53 AEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCF 112
A+ LY GPWGRC GD CGPGG+Q+RAVWC HV+GWT+ +NC ++ RP +++CF
Sbjct: 5 ADEVVLYHKLAGPWGRCTGD-CGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF 63
Query: 113 KVCDWHKELYDWRLGPWNQCQPV-ISKSLEKP--LECIKGEEGIQVREIACIQKDKDIPA 169
+VCDWH +L+ W + W+ C V ++ KP EC+ + G+Q R + CIQK
Sbjct: 64 RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVV 123
Query: 170 EDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGG 229
+ ICE+F +P EQACLIPC +DC+VSEF WS CSK CG LQHRTR V+APP FGG
Sbjct: 124 ANEICEHFALQPPTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGG 183
Query: 230 SGCPNLTEFQVCQ---SSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKD 286
CPNLTE + C S P EE +SL VGPWS C +PH +++ + R + + +
Sbjct: 184 LQCPNLTESRACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSN 243
Query: 287 RSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQE 346
K +++ + +K W I+IGYQTR+V C G+ A LS C Q+
Sbjct: 244 ERVTFK------------HQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQD 291
Query: 347 KLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEF 406
P+T QSC++ K+C+ S+WS WSPCSKTC G R R+R ++ IG KECPE
Sbjct: 292 SFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPEL 351
Query: 407 EEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYC 466
EKE C+ +G+ + C Y WRT+EW EC+V LL QQD +CGGGIQTREVYC
Sbjct: 352 LEKEACIVEGELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC 411
Query: 467 VQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTY 526
Q+ + + + KE S+P++ LC GP P +QLC+IPC T+C VS WSAWG C +
Sbjct: 412 AQS----VPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIH 467
Query: 527 ENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEP 586
ENC+D QGKKGF+ R+R + E TG +G +CPHL+E++PCE+P CY W A G C P
Sbjct: 468 ENCHDPQGKKGFRTRQRHVLMESTGPAG---HCPHLVESVPCEDPMCYRWLASE-GICFP 523
Query: 587 DNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSC 646
D+GK CG G ++ + VC N GE+V LC P +C+ PC DCVLS W+ WSSC
Sbjct: 524 DHGK-CGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEIPCRMDCVLSEWTEWSSC 582
Query: 647 SHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQ 706
S +CS K ++GKQ R+R+ILA AGE GG CP S ALQE R CN+H C HW+T PWG
Sbjct: 583 SQSCSNKNSDGKQTRSRTILALAGE-GGKPCPPSQALQEHRLCNDHSCMQLHWETSPWGP 641
Query: 707 CIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLL 766
C EDT V++ N T WNGEA+C VG+QTR+V CV+ +VGQV K+CP+S RPETVRPC L
Sbjct: 642 CSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPETVRPCFL 701
Query: 767 PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEA 826
PCKKDCIVT +S+WT CP C+ G++++ KQSR+R+IIQ ANGG++C D LYEE+ CE
Sbjct: 702 PCKKDCIVTAFSEWTPCPRMCQAGNATV-KQSRYRIIIQEAANGGQECPDTLYEERECED 760
Query: 827 PQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECL 886
C YRWK KW C LVP SV Q G+ E CG G Q RA++C D A + ECL
Sbjct: 761 VSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECL 820
Query: 887 QYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSH 946
+ +P L Q C +PC++DC T+WSKF+ C+ +C A ++R+R L GKS+KKEKC++S
Sbjct: 821 KQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGKSRKKEKCQDSD 880
Query: 947 LYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACY 1006
LYPL+ET+ CPCD++ +QP GNWSDCILPEG+ E G++VQ D KECG+G R++A+AC
Sbjct: 881 LYPLVETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACS 940
Query: 1007 DQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKP 1066
D+NGR V+ S C+S GYI+E C+IPCP DCKLS+WS+W CS SCG GV++RSKWL+EKP
Sbjct: 941 DKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKP 1000
Query: 1067 YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRK 1126
YNGGRPCPKLD NQAQV+E VPC+S+CNQY WV E WS CK+ CG G Q+RK
Sbjct: 1001 YNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRK 1060
Query: 1127 VRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSF 1186
+RC+ NTADG V+ LC+ +E+P ++ C L CP +CV+SEWG W++C C+ +
Sbjct: 1061 IRCV-NTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTM 1119
Query: 1187 RQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKT 1246
++R+ +R P+ R+C + +PC LN+NC+ + YN+T+WSTCQLSE A CG G++T
Sbjct: 1120 QRRTRHLLR-PSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRT 1178
Query: 1247 RMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTG 1306
R+L CV SDGK V + CE LEK +M+ C+VEC VNCQLS W+ W+ECSQTCG G
Sbjct: 1179 RLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGG 1238
Query: 1307 KMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRN 1366
+M R R + P QG+GRPCP+ + Q K CPV PCY W G WS C+++ CGEG + R+
Sbjct: 1239 RMSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRS 1298
Query: 1367 ISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLC 1426
+SC+V GS + V++ C ++ ++ +L++ CS PCPGDC+L +WS WS C
Sbjct: 1299 LSCMVHSGSISHAAGRVEDALCGEMPF-----QDSILKQLCSVPCPGDCHLTEWSEWSTC 1353
Query: 1427 QLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKG 1486
+LTC++G G Q RSR IIQ ENQ CP+Q+LET+ C G+CY Y W AS W
Sbjct: 1354 ELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRPCTGGKCYHYTWKASLWNN 1413
Query: 1487 SSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCEEGYTEVMSS 1546
+ RTVWCQRSDG+NVTGGC ++P A R C P C +P SYC++ C CE+GYTE+M S
Sbjct: 1414 NERTVWCQRSDGVNVTGGCSPQARPAAIRQCIPACRKPFSYCTQGGVCGCEKGYTEIMKS 1473
Query: 1547 NSTLEQCTLIPVVVLPTMEDKRGDVKT-SRAVHPTQPSSNPAGRGRTWFLQPFGPDGRLK 1605
N L+ C + +P EDK+ DVK S P + +G W LQP PDGR+K
Sbjct: 1474 NGFLDYC-----MKVPGSEDKKADVKNLSGKNRPVNSKIHDIFKG--WSLQPLDPDGRVK 1526
Query: 1606 TWVYGVAAGAFVLLIFIVSMIYLACKKPKKPQRRQNNRLKPLTLAYDGDADM 1657
WVYGV+ GAF+++IF++ YL CKKP KP + + KPLTLAYDGD DM
Sbjct: 1527 IWVYGVSGGAFLIMIFLIFTSYLVCKKP-KPHQSTPPQQKPLTLAYDGDLDM 1577
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 169 bits (429), Expect = 2e-41
Identities = 219/954 (22%), Positives = 347/954 (36%), Gaps = 186/954 (19%)
Query: 499 PNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQ-QGKKGFKLRKRRITNEPTGGSGVTG 557
P+ +IP + + W++ GP ++ C+ QG++ KL R +++ T
Sbjct: 862 PDVRYSFNIPIEDKPQQFYWNSHGP--WQACSKPCQGERKRKLVCTRESDQLTVSDQRCD 919
Query: 558 NCP---HLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVC-----INSDGE 609
P H+ E PC W C +CG G + ++ C ++ E
Sbjct: 920 RLPQPGHITE--PCGTDCDLRWHVASRSECSA----QCGLGYRTLDIYCAKYSRLDGKTE 973
Query: 610 EVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILA 667
+VD C P + C +C W S W+ CS +C G T + I +
Sbjct: 974 KVDDGFCSSHPKP---SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND 1030
Query: 668 YAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEAS 727
+ +C + + ++ C+E PC W++G W +C+ +
Sbjct: 1031 VLDDS---KCTHQEKVT-IQRCSEFPCP--QWKSGDWSECL-----------------VT 1067
Query: 728 CSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSC 787
C G + R+V C + ++ + C +P +++ C P +C W C +C
Sbjct: 1068 CGKGHKHRQVWC-QFGEDRLNDRMCDPETKPTSMQTCQQP---ECASWQAGPWGQCSVTC 1123
Query: 788 KEGDSSIRKQ----SRHRVIIQLPANGGRDCTDPL-YEEKACEAPQACQSYRWKTHKWRR 842
+G + + V+ N TD E +C P A R T+ R
Sbjct: 1124 GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPR 1183
Query: 843 CQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP 902
Q W +P CG G + R ++CR ++G A C P P + C +
Sbjct: 1184 TQ---WRFGSWTP-CSATCGKGTRMRYVSCRDENGSVADESACATL--PRPVAKEECSVT 1237
Query: 903 CQDDCQLTSWSKFSSCNGDCGAVR-TRKRTLVGKSKK---KEKCKNSHLYPLIET-QYCP 957
+ WS SC+ CG R TR+ V S + +C ++ + P
Sbjct: 1238 PCGQWKALDWS---SCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSP 1294
Query: 958 C-----DKYNAQ-PVGN--WSDCILPEGKVEVLLGMKVQGD-----IKECGQGYRYQAMA 1004
C D AQ P N + + VL G + + C G + + +
Sbjct: 1295 CPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVV 1354
Query: 1005 CYDQNGRLVETSRCNSHGYIEEACII-PCPSDCKLSEWS--NWSRCSKSCGSGVKVRSKW 1061
C D+NG + AC PCP +W+ NW C+K CG G++ R
Sbjct: 1355 CQDENGYTANDCVERIKPDEQRACESGPCP------QWAYGNWGECTKLCGGGIRTRLVV 1408
Query: 1062 LREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYL------WVTEPWSICKVTFVNMR 1115
+ + G P L ++ + P CN + W T PWS C V+
Sbjct: 1409 CQR---SNGERFPDLS----CEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVS----- 1456
Query: 1116 ENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLP-CPEDCVISEW--G 1172
CG G + R V CM DG H+E C P G R C+ CP+ W G
Sbjct: 1457 --CGRGHKQRNVYCMAK--DG--SHLESDYCKHLAKPHGHRKCRGGRCPK------WKAG 1504
Query: 1173 PWTQCVLPCNQSS--------------FRQRSADPIRQPADEGRSCPNAVEKEPCNLNKN 1218
W+QC + C + R+ +P +P E R C
Sbjct: 1505 AWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESE-RDCQGP----------R 1553
Query: 1219 CYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTS 1278
C Y + +W C + CG G + R + CV + V C+ + K S
Sbjct: 1554 CPLYTWRAEEWQECTKT----CGEGSRYRKVVCVDDNKNEVHGARCD---VSKRPVDRES 1606
Query: 1279 CMVECPVNCQLSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQGDGR---------PCPS 1327
C ++ C+ W WSECS TCG G R + ++ + G CP
Sbjct: 1607 CSLQ---PCEYV-WITGEWSECSVTCG-KGYKQRLVSCSEIYTGKENYEYSYQTTINCPG 1661
Query: 1328 LMDQSKPCPVKPCY--------RWQYGQWSPCQVQEAQCGEGTRTRNISCVVSD 1373
++P V PCY W+ G W C V CG G R++ C+ ++
Sbjct: 1662 ----TQPPSVHPCYLRDCPVSATWRVGNWGSCSV---SCGVGVMQRSVQCLTNE 1708
Score = 162 bits (409), Expect = 3e-39
Identities = 230/1001 (22%), Positives = 332/1001 (33%), Gaps = 238/1001 (23%)
Query: 258 GPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYW 317
GPW CS P + R+R RE D+ V D L + + W
Sbjct: 885 GPWQACSKPCQGE----RKRKLVCTRESDQLT-VSDQRCDRLPQPGHITEPCGTDCDLRW 939
Query: 318 DIQ----------IGYQTREVMCIN------KTGKAADLSFCQQEKLPMTFQSCVITKEC 361
+ +GY+T ++ C KT K D FC P + C + EC
Sbjct: 940 HVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDD-GFCSSHPKPSNREKC--SGEC 996
Query: 362 QVSEW--SEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGV 419
W S W+ CSK+C G R R I + + +E Q
Sbjct: 997 NTGGWRYSAWTECSKSCD------GGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSE 1050
Query: 420 VPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLST 479
PC W++ +W+EC V CG G + R+V+C + L ++
Sbjct: 1051 FPCPQ--WKSGDWSECLVT----------------CGKGHKHRQVWCQFGEDRLNDRMCD 1092
Query: 480 HKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSA--WGPCTYENCNDQQGKKG 537
+ K P + Q C P E + W A WG C+ C +G
Sbjct: 1093 PETK---------------PTSMQTCQQP-----ECASWQAGPWGQCSV-TCG-----QG 1126
Query: 538 FKLRKRRI---TNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAV--------------- 579
++LR + T + CE P+C+ A
Sbjct: 1127 YQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQW 1186
Query: 580 RLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLST 639
R G+ P + CG GT+++ V C + +G D C A P PVA + C
Sbjct: 1187 RFGSWTPCSAT-CGKGTRMRYVSCRDENGSVADESAC--ATLPRPVAKEECSVTPCGQWK 1243
Query: 640 WSTWSSCSHTCSGKTTEGKQIRARSILAYAGEE-GGIRCPNSSALQEVRSCNEHPCTVY- 697
WSSCS TC +G+ R + Y+ C + + C+ PC
Sbjct: 1244 ALDWSSCSVTCG----QGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRT 1299
Query: 698 -------------------------------HWQTGPWGQCIEDTSVSSFNTTTTWNGEA 726
W+TGPWG C +
Sbjct: 1300 PDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGAC-----------------SS 1342
Query: 727 SCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLL-PCKKDCIVTPYSDWTSCPS 785
+C+ G Q R V+C N C E ++P+ R C PC + Y +W C
Sbjct: 1343 TCAGGSQRRVVVCQDEN--GYTANDCVERIKPDEQRACESGPCPQ----WAYGNWGECTK 1396
Query: 786 SCKEGDSSIRKQSRHRVIIQLPANGGR------DCTDPLYEEKACEAPQACQSYRWKTHK 839
C G R R+++ +NG R + D + + C W T
Sbjct: 1397 LCGGG-------IRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGP 1449
Query: 840 WRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQAC 899
W C + CG G + R + C +DG C A P + C
Sbjct: 1450 WSSCSV--------------SCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGH--RKC 1493
Query: 900 QIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCD 959
+ C +S C+ CG G ++ C+ ET+ P
Sbjct: 1494 R---GGRCPKWKAGAWSQCSVSCGR---------GVQQRHVGCQIGTHKIARETECNPYT 1541
Query: 960 KYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRC- 1018
+ ++ DC P + + Q K CG+G RY+ + C D N V +RC
Sbjct: 1542 RPESE-----RDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCD 1596
Query: 1019 -NSHGYIEEACII-PCPSDCKLSEWSNWSRCSKSCGSGVKVR---------SKWLREKPY 1067
+ E+C + PC E WS CS +CG G K R K E Y
Sbjct: 1597 VSKRPVDRESCSLQPCEYVWITGE---WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
Query: 1068 NGGRPCPKLDHVNQAQVYEVVPCH-SDCN-QYLWVTEPWSICKVTFVNMRENCGEGVQTR 1125
CP Q V PC+ DC W W C V +CG GV R
Sbjct: 1654 QTTINCP------GTQPPSVHPCYLRDCPVSATWRVGNWGSCSV-------SCGVGVMQR 1700
Query: 1126 KVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDC 1166
V+C+ N D PS H+ PEE V P++C
Sbjct: 1701 SVQCLTN-EDQPS-HLCHTDLKPEERKTCRNVYNCELPQNC 1739
Score = 141 bits (355), Expect = 6e-33
Identities = 233/1014 (22%), Positives = 349/1014 (34%), Gaps = 231/1014 (22%)
Query: 54 EAPTLYLWKT-GPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNN-QQNC 111
+ P + W + GPW C C G + + V + T C + +P + + C
Sbjct: 874 DKPQQFYWNSHGPWQAC-SKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPC 931
Query: 112 FKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKD-KDIPAE 170
CD W + ++C +C G + + + D K +
Sbjct: 932 GTDCDLR-----WHVASRSECSA----------QCGLGYRTLDIYCAKYSRLDGKTEKVD 976
Query: 171 DIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHR------TRHVVAP 224
D C PKP + C C +SAW+ECSK+C G Q R TR+ V
Sbjct: 977 DGFCSS-HPKPSNREKCSGECNTGGW--RYSAWTECSKSCDGGTQRRRAICVNTRNDV-- 1031
Query: 225 PQFGGSGCPNLTE--FQVCQSSPCEAEELRYSLHVGPWS----TCSMPHSRQVRQARRRG 278
S C + + Q C PC G WS TC H + +
Sbjct: 1032 --LDDSKCTHQEKVTIQRCSEFPCP------QWKSGDWSECLVTCGKGHKHRQVWCQ--- 1080
Query: 279 KNKEREKDRSKGVKDPEAREL-IKKKRNRNRQNRQENKYWDIQI----GYQTREVMCINK 333
++R DR + DPE + ++ + + Q + + GYQ R V CI
Sbjct: 1081 FGEDRLNDR---MCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIG 1137
Query: 334 T-GKAADLSFCQQEKLPMTFQSCVI---------------TKECQVSEW--SEWSPCSKT 375
T D + C P Q C + T ++W W+PCS T
Sbjct: 1138 TYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSAT 1197
Query: 376 CHDMVSPAGTRVRTRTIR--QFPIGSEKEC---PEFEEKEPCLSQGDGVVPCATYGWRTT 430
C GTR+R + R + E C P KE C V PC W+
Sbjct: 1198 C-----GKGTRMRYVSCRDENGSVADESACATLPRPVAKEEC-----SVTPCGQ--WKAL 1245
Query: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKN--KEASKP 488
+W+ C V CG G TR+V CV +++++ + ++ E +
Sbjct: 1246 DWSSCSV----------------TCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD 1289
Query: 489 MDLKLCTGPIPNTTQLCH----------IPCPTECEV---SPW--SAWGPCTYENCNDQQ 533
+ C P++ H P+ V + W WG C+ Q
Sbjct: 1290 CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQ 1349
Query: 534 GKKGFKLRKRRITNEPTGGSGVTGNCPHLL---EAIPCEEPACYDWKAVRLGNCEPDNGK 590
RR+ +C + E CE C W G C K
Sbjct: 1350 ---------RRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECT----K 1396
Query: 591 ECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIP-VACDA-PCPKDCVLSTWSTWSSCSH 648
CG G + + VVC S+GE C P C+ CP D ST WSSCS
Sbjct: 1397 LCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWST-GPWSSCSV 1455
Query: 649 TCSGKTTEGKQIRARSILAYAGEEGGIR---CPNSSALQEVRSCNEHPCTVYHWQTGPWG 705
+C G+ + R++ A + + C + + R C C W+ G W
Sbjct: 1456 SC------GRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCP--KWKAGAWS 1507
Query: 706 QCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKK------CPESLRPE 759
QC SC G+Q R V C Q+G K C RPE
Sbjct: 1508 QC-----------------SVSCGRGVQQRHVGC------QIGTHKIARETECNPYTRPE 1544
Query: 760 TVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPAN-----GGR-D 813
+ R C P + +W C +C EG SR+R ++ + N G R D
Sbjct: 1545 SERDCQGP-RCPLYTWRAEEWQECTKTCGEG-------SRYRKVVCVDDNKNEVHGARCD 1596
Query: 814 CTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCR 873
+ + ++C Q C+ Y W T +W C + CG G + R ++C
Sbjct: 1597 VSKRPVDRESCSL-QPCE-YVWITGEWSECSVT--------------CGKGYKQRLVSCS 1640
Query: 874 KQDGGQAGIHECLQYAGPVPALTQACQIPCQ-DDCQLT-SW--SKFSSCNGDCGAVRTRK 929
+ G+ Q P PC DC ++ +W + SC+ CG
Sbjct: 1641 EIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCG------ 1694
Query: 930 RTLVGKSKKKEKCKNSHLYP--LIETQYCPCDKYNAQPVGNWSDCILPEGKVEV 981
VG ++ +C + P L T P ++ + V N C LP+ EV
Sbjct: 1695 ---VGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYN---CELPQNCKEV 1742
Score = 140 bits (354), Expect = 8e-33
Identities = 197/814 (24%), Positives = 284/814 (34%), Gaps = 209/814 (25%)
Query: 831 QSYRWKTH-KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYA 889
Q + W +H W+ C + C R+ + + R+ D C +
Sbjct: 877 QQFYWNSHGPWQACS--------------KPCQGERKRKLVCTRESDQLTVSDQRCDRLP 922
Query: 890 GPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCG-AVRT------RKRTLVGKSKKKE 940
P +T+ PC DC L W + S C+ CG RT + L GK++K +
Sbjct: 923 QP-GHITE----PCGTDCDLR-WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVD 976
Query: 941 K--CKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGY 998
C +SH P + W++C K C G
Sbjct: 977 DGFC-SSHPKPSNREKCSGECNTGGWRYSAWTECS------------------KSCDGGT 1017
Query: 999 RYQAMACYDQNGRLVETSRCNSHGY--IEEACIIPCPSDCKLSEWSN--WSRCSKSCGSG 1054
+ + C + +++ S+C I+ PCP +W + WS C +CG G
Sbjct: 1018 QRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCP------QWKSGDWSECLVTCGKG 1071
Query: 1055 VKVRSKWLR--EKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFV 1112
K R W + E N R C Q + C S W PW C VT
Sbjct: 1072 HKHRQVWCQFGEDRLN-DRMCDPETKPTSMQTCQQPECAS------WQAGPWGQCSVT-- 1122
Query: 1113 NMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLP-------CPE- 1164
CG+G Q R V+C+ T V+D C+ P ++ C+LP PE
Sbjct: 1123 -----CGQGYQLRAVKCIIGTY---MSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPET 1174
Query: 1165 -----DCVISEW--GPWTQCVLPCNQSSFRQR---SADPIRQPADEG--RSCPNAVEKEP 1212
++W G WT C C + + R R D ADE + P V KE
Sbjct: 1175 RRSTYSAPRTQWRFGSWTPCSATCGKGT-RMRYVSCRDENGSVADESACATLPRPVAKEE 1233
Query: 1213 CNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKN 1272
C++ C + DWS+C ++ CG G TR + CV +D C+ + +
Sbjct: 1234 CSVTP-C--GQWKALDWSSCSVT----CGQGRATRQVMCVNYSDHVIDRSECDQDYIPET 1286
Query: 1273 WQMNTSCMVECPVNC----------QLSDW--------------------SPWSECSQTC 1302
Q M CP Q D+ PW CS TC
Sbjct: 1287 DQ--DCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
Query: 1303 GLTGKMIRRRTVTQPFQG-DGRPCPSLM--DQSKPCPVKPCYRWQYGQWSPCQVQEAQCG 1359
G RR V Q G C + D+ + C PC +W YG W C CG
Sbjct: 1345 --AGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGEC---TKLCG 1399
Query: 1360 EGTRTRNISCVVSDG------SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPG 1413
G RTR + C S+G S + K D E C + CP
Sbjct: 1400 GGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCN------------------THACPH 1441
Query: 1414 DCYLKDWSS--WSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLET----- 1466
D WS+ WS C ++C G + R V + HL +
Sbjct: 1442 DA---AWSTGPWSSCSVSCGRGH---------KQRNVYCMAKDGSHLESDYCKHLAKPHG 1489
Query: 1467 -KSCYDGQCYEYKWMASAWKGSS---------RTVWCQ-RSDGINVTGGCLVMSQPDADR 1515
+ C G+C KW A AW S R V CQ + I C ++P+++R
Sbjct: 1490 HRKCRGGRC--PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESER 1547
Query: 1516 SCNPPCSQPHSYCSE-----TKTCHCEEGYTEVM 1544
C P +++ +E TKTC Y +V+
Sbjct: 1548 DCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVV 1581
Score = 123 bits (308), Expect = 2e-27
Identities = 175/769 (22%), Positives = 264/769 (34%), Gaps = 206/769 (26%)
Query: 848 WSVQQDSPGAQEGCGPGRQARAITCRKQ---DGGQAGIHECLQYAGPVPALTQACQIPCQ 904
W V S + + CG G + I C K DG + + + P P+ + C
Sbjct: 939 WHVASRSECSAQ-CGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCS---- 993
Query: 905 DDCQLTSW--SKFSSCNGDCGAVRTRKRTLVGKSKKK----EKCKNSHLYPLIETQYCPC 958
+C W S ++ C+ C R+R + ++ KC + + PC
Sbjct: 994 GECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPC 1053
Query: 959 DKYNAQPVGNWSDCILPEGK------------VEVLLGMKVQGDIKE------------- 993
++ + G+WS+C++ GK + L + K
Sbjct: 1054 PQWKS---GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECAS 1110
Query: 994 ------------CGQGYRYQAMACY-DQNGRLVETSRCNSHGYIEEACIIPCPS------ 1034
CGQGY+ +A+ C +V+ + CN+ + PS
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
Query: 1035 ---------DCKLSEW--SNWSRCSKSCGSGVKVRSKWLREKPYNGG----RPCPKLDHV 1079
++W +W+ CS +CG G ++R R++ NG C L
Sbjct: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDE--NGSVADESACATLPRP 1228
Query: 1080 NQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSE 1139
+ V PC W WS C VT CG+G TR+V C+ S+
Sbjct: 1229 VAKEECSVTPCGQ------WKALDWSSCSVT-------CGQGRATRQVMCVNY-----SD 1270
Query: 1140 HVEDYL-CDPEEMPLGSRVCKL-PCPEDCVIS---------------------------- 1169
HV D CD + +P + C + PCP+ S
Sbjct: 1271 HVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGN 1330
Query: 1170 EW--GPWTQCVLPCNQSSFRQ----------RSADPI-RQPADEGRSCPNAVEKEPCNLN 1216
+W GPW C C S R+ + D + R DE R+C E PC
Sbjct: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRAC----ESGPCP-- 1384
Query: 1217 KNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKN-WQM 1275
+ +W C +CG GI+TR++ C RS+G+ CE L + Q
Sbjct: 1385 ------QWAYGNWGECT----KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQC 1434
Query: 1276 NTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKP- 1334
NT CP + S PWS CS +CG K +R G +KP
Sbjct: 1435 NTHA---CPHDAAWST-GPWSSCSVSCGRGHK--QRNVYCMAKDGSHLESDYCKHLAKPH 1488
Query: 1335 ----CPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCAD 1390
C C +W+ G WS C V CG G + R++ C + K+ E C
Sbjct: 1489 GHRKCRGGRCPKWKAGAWSQCSV---SCGRGVQQRHVGCQIGT------HKIARETEC-- 1537
Query: 1391 IELIIDGNKNMVLEESCSQPCPGD-CYLKDW--SSWSLCQLTCVNGEDLGFGGIQVRSRP 1447
N + C G C L W W C TC G R R
Sbjct: 1538 ---------NPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGS---------RYRK 1579
Query: 1448 VIIQELENQHL------CPEQMLETKSCYDGQCYEYKWMASAWKGSSRT 1490
V+ + + ++ ++ +SC C EY W+ W S T
Sbjct: 1580 VVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC-EYVWITGEWSECSVT 1627
Score = 78.6 bits (192), Expect = 5e-14
Identities = 102/430 (23%), Positives = 149/430 (34%), Gaps = 83/430 (19%)
Query: 1163 PEDCVISEWGPWTQCVLPCNQSSFRQ----RSADPIRQPADEGRSCPNAVE-KEPCNLNK 1217
P+ + GPW C PC R+ R +D + P EPC +
Sbjct: 876 PQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDC 935
Query: 1218 NCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCV---RSDGKS--VDLKYCEALGLEKN 1272
+ ++V S C A CG G +T + C R DGK+ VD +C + N
Sbjct: 936 D---LRWHVASRSEC----SAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN 988
Query: 1273 WQMNTSCMVECPVNCQLSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMD 1330
+ +C C W S W+ECS++C G RRR + + D
Sbjct: 989 RE-------KCSGECNTGGWRYSAWTECSKSC--DGGTQRRRAICVNTRNDVLDDSKCTH 1039
Query: 1331 QSK----PCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEE 1386
Q K C PC +W+ G WS C V CG+G + R + C + +D
Sbjct: 1040 QEKVTIQRCSEFPCPQWKSGDWSECLV---TCGKGHKHRQVWCQFGEDRLND-------- 1088
Query: 1387 FCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDL---------- 1436
+ D ++C QP +C W C +TC G L
Sbjct: 1089 ------RMCDPETKPTSMQTCQQP---ECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTY 1139
Query: 1437 ----GFGGIQVRSRPVIIQ--ELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRT 1490
+RP Q EL + H P +S Y +W +W S T
Sbjct: 1140 MSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAP--RTQWRFGSWTPCSAT 1197
Query: 1491 ---------VWCQRSDG-INVTGGCLVMSQPDADRSCN-PPCSQ--PHSYCSETKTCHCE 1537
V C+ +G + C + +P A C+ PC Q + S + TC
Sbjct: 1198 CGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQG 1257
Query: 1538 EGYTEVMSSN 1547
+VM N
Sbjct: 1258 RATRQVMCVN 1267
Score = 38.1 bits (87), Expect = 0.071
Identities = 39/181 (21%), Positives = 60/181 (33%), Gaps = 71/181 (39%)
Query: 71 GDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWN 130
G + P +Q R +WC +V G +H C+ P W G
Sbjct: 528 GSQVCPYMMQCRRLWCNNVNG---VHKGCRTQHTP------------------WADG--T 564
Query: 131 QCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIP 190
+C+P G + C+ K+ D+P D
Sbjct: 565 ECEP-----------------GKHCKYGFCVPKEMDVPVTD------------------- 588
Query: 191 CQQDCIVSEFSAWSE---CSKTCGSGLQHRTRHVVAP-PQFGGSGC-PNLTEFQVCQSSP 245
+ +WS CS+TCG G++ R P P+ GG C +F+ C + P
Sbjct: 589 -------GSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEP 641
Query: 246 C 246
C
Sbjct: 642 C 642
Score = 37.0 bits (84), Expect = 0.16
Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 6/75 (8%)
Query: 1005 CYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSE--WSNWS---RCSKSCGSGVKVRS 1059
C Q+ + + C + + +P D +++ W +WS CS++CG G+K
Sbjct: 553 CRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAI 612
Query: 1060 KWL-REKPYNGGRPC 1073
+ R +P NGG+ C
Sbjct: 613 RECNRPEPKNGGKYC 627
Score = 35.0 bits (79), Expect = 0.60
Identities = 35/141 (24%), Positives = 53/141 (37%), Gaps = 35/141 (24%)
Query: 559 CPHLLEAIPCEEPACYDWKAVRLGNCEPDN-----GKECGPGTQVQEVVCINSDGEEVDR 613
CP++++ C C + V G C + G EC PG + C+ +E+D
Sbjct: 532 CPYMMQ---CRRLWCNNVNGVHKG-CRTQHTPWADGTECEPGKHCKYGFCVP---KEMD- 583
Query: 614 QLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEG 673
+PV D +WS + +CS TC G G + R + G
Sbjct: 584 ---------VPVT-------DGSWGSWSPFGTCSRTCGG----GIKTAIRECNRPEPKNG 623
Query: 674 GIRCPNSSALQEVRSCNEHPC 694
G C + +SCN PC
Sbjct: 624 GKYCVGRR--MKFKSCNTEPC 642
Score = 33.1 bits (74), Expect = 2.3
Identities = 16/51 (31%), Positives = 23/51 (45%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYR 1342
WSP+ CS+TCG K R + G+ C + K C +PC +
Sbjct: 594 WSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLK 644
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 149 bits (376), Expect = 2e-35
Identities = 222/1006 (22%), Positives = 362/1006 (35%), Gaps = 195/1006 (19%)
Query: 461 TREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPI--PNTTQLCHIPCPTECEVSPW 518
TR V + N + ++++ +E + + LC G + P+ +IP ++ W
Sbjct: 792 TRTVIEYSGSNNAVERINSTNRQEKELILQV-LCVGNLYNPDVHYSFNIPLEERSDMFTW 850
Query: 519 SAWGPCTYENCNDQ-QGKKGFKLRKRRITNEPTGGSGVTGN--CPHL----LEAIPCEEP 571
+GP +E C QG L++R IT V + C HL C
Sbjct: 851 DPYGP--WEGCTKMCQG-----LQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD 903
Query: 572 ACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCIN---SDGE--EVDRQLCRDAIFPIPVA 626
W + C +CG G + ++ C+ +G+ +VD C D + P
Sbjct: 904 CELRWHVIGKSECS----SQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP---P 956
Query: 627 CDAPCPKDCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQ 684
C +CV + W S WS CS +C G RS +Y G R ++ +
Sbjct: 957 TQELCHGNCVFTRWHYSEWSQCSRSCGGGE--------RSRESYCMNNFGHRLADNECQE 1008
Query: 685 EVR----SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICV 740
R +CNE C W W +C+ +C G + R+V C
Sbjct: 1009 LSRVTRENCNEFSCP--SWAASEWSECL-----------------VTCGKGTKQRQVWC- 1048
Query: 741 RVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEG---------- 790
++NV + C S +PE++ PC L C W C ++C G
Sbjct: 1049 QLNVDHLSDGFCNSSTKPESLSPCEL---HTCASWQVGPWGPCTTTCGHGYQMRDVKCVN 1105
Query: 791 --------DSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRR 842
D+ + SR P++ P E K +WR
Sbjct: 1106 ELASAVLEDTECHEASR-------PSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRH 1158
Query: 843 CQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP 902
P SV CG G QAR ++CR A C P PA C P
Sbjct: 1159 GSWTPCSVS---------CGRGTQARYVSCRDALDRIADESYCAHL--PRPAEIWDCFTP 1207
Query: 903 CQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKK--EKCKNSHLYPLIETQY----C 956
C + Q WS C+ CG +T ++ L + E + + PL+E + C
Sbjct: 1208 C-GEWQAGDWSP---CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
Query: 957 PC--DKYNAQPV--GNWSDCILP-----EGKVEVLLGMKVQGD----------IKECGQG 997
P + + PV + LP E ++ V+G+ C G
Sbjct: 1264 PPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGG 1323
Query: 998 YRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPC-PSDCKLSEWSNWSRCSKSCGSGVK 1056
+++A+ C D+NG+ S C++ E + C P C + NW CS++CG G+K
Sbjct: 1324 LQHRAVVCQDENGQ--SASYCDAASKPPE--LQQCGPGPCPQWNYGNWGECSQTCGGGIK 1379
Query: 1057 VRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDC--NQYLWVTEPWSICKVTFVNM 1114
R + + P + VN+ V+ CH W EPW+ C +
Sbjct: 1380 SRLV-ICQFPNGQILEDHNCEIVNKPP--SVIQCHMHACPADVSWHQEPWTSCSAS---- 1432
Query: 1115 RENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK-LPCPEDCVISEW-- 1171
CG+G + R+V C+ D +ED C + P + C+ + CP W
Sbjct: 1433 ---CGKGRKYREVFCI----DQFQRKLEDTNCSQVQKPPTHKACRSVRCPS------WKA 1479
Query: 1172 GPWTQCVLPCNQSSFRQRSA----DPIRQPADEGRSCPNAVEKEPCNLNK----NCYHYD 1223
W +C + C S +QR + Q +E C + PC+ + +C +
Sbjct: 1480 NSWNECSVTCG-SGVQQRDVYCRLKGVGQVVEE--MCDQSTR--PCSQRRCWSQDCVQHK 1534
Query: 1224 YNVTDWSTCQLS-------EKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMN 1276
C S ++ C + + R ++ + + ++ L N+ +
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDN-QIRQVNEIVYNSSTISLTSKNCRNPPCNYIVV 1593
Query: 1277 TSCMVECPVNCQLSDWSPWSECSQTCGLTG-KMIRRRTVTQPFQGDGRPCPSLMDQSKPC 1335
T+ +C NC S + C++ K+ R R + + CP +
Sbjct: 1594 TADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVY------QECPVVPSSQVYQ 1647
Query: 1336 PVKPCYR---WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADD 1378
+ C W+ G+WS C V CG G R + C+ G + D
Sbjct: 1648 CINSCLHLATWKVGKWSKCSV---TCGIGIMKRQVKCITKHGLSSD 1690
Score = 137 bits (344), Expect = 1e-31
Identities = 222/1001 (22%), Positives = 356/1001 (35%), Gaps = 235/1001 (23%)
Query: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVS 381
G Q R + CI+K+ + +S + + LP+ +T+ C W K+ + S
Sbjct: 865 GLQRRNITCIHKSDHSV-VSDKECDHLPLP---SFVTQSCNTDCELRWHVIGKS--ECSS 918
Query: 382 PAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVP---------CATYGWRTTEW 432
G RT I + + C GD + P C W +EW
Sbjct: 919 QCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC---GDQLKPPTQELCHGNCVFTRWHYSEW 975
Query: 433 TECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLK 492
++C + CGGG ++RE YC+ N +L+ ++ +E S+
Sbjct: 976 SQC----------------SRSCGGGERSRESYCMN---NFGHRLADNECQELSRV---- 1012
Query: 493 LCTGPIPNTTQLCH-IPCPTECEVSPWSA--WGPCTYENCNDQQGKKGFKLRKRRITNEP 549
T + C+ CP+ W+A W C C +G K ++ + +
Sbjct: 1013 --------TRENCNEFSCPS------WAASEWSECLV-TCG--KGTKQRQVWCQLNVDHL 1055
Query: 550 TGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGE 609
+ G + P L PCE C W+ G C CG G Q+++V C+N
Sbjct: 1056 SDGFCNSSTKPESLS--PCELHTCASWQVGPWGPCTTT----CGHGYQMRDVKCVNELAS 1109
Query: 610 EV-DRQLCRDAIFPIP-VACD-APCPKDCVLST-------------W--STWSSCSHTCS 651
V + C +A P +C PC L T W +W+ CS +C
Sbjct: 1110 AVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSC- 1168
Query: 652 GKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDT 711
G+ T+ + + R L +E C + E+ C PC WQ G W C
Sbjct: 1169 GRGTQARYVSCRDALDRIADES--YCAHLPRPAEIWDCFT-PCG--EWQAGDWSPC---- 1219
Query: 712 SVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKD 771
ASC G TR+V+C+ + + C +RP + C L
Sbjct: 1220 -------------SASCGHGKTTRQVLCMNYHQ-PIDENYCDPEVRPLMEQECSL----- 1260
Query: 772 CIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQ 831
+CP + SS Q + + LP T L + + + +
Sbjct: 1261 ---------AACPPAHSHFPSS-PVQPSYYLSTNLPL------TQKLEDNENQVVHPSVR 1304
Query: 832 SYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGP 891
+W+T W C C G Q RA+ C+ ++G A + A
Sbjct: 1305 GNQWRTGPWGSCS--------------SSCSGGLQHRAVVCQDENGQSASYCDA---ASK 1347
Query: 892 VPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLV-----GKSKKKEKCKNSH 946
P L Q PC ++ + C+ CG + R ++ G+ + C+ +
Sbjct: 1348 PPELQQCGPGPCPQ----WNYGNWGECSQTCGG-GIKSRLVICQFPNGQILEDHNCEIVN 1402
Query: 947 LYPLI---ETQYCPCD-KYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQA 1002
P + CP D ++ +P W+ C CG+G +Y+
Sbjct: 1403 KPPSVIQCHMHACPADVSWHQEP---WTSCSA------------------SCGKGRKYRE 1441
Query: 1003 MACYDQNGRLVETSRCNS--HGYIEEAC-IIPCPSDCKLSEW--SNWSRCSKSCGSGVKV 1057
+ C DQ R +E + C+ +AC + CPS W ++W+ CS +CGSGV+
Sbjct: 1442 VFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS------WKANSWNECSVTCGSGVQQ 1495
Query: 1058 RSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS--DCNQYLWVTEPWSICKVTFVNM- 1114
R + R K QV E + S C+Q WS V M
Sbjct: 1496 RDVYCRLK--------------GVGQVVEEMCDQSTRPCSQ----RRCWSQDCVQHKGME 1537
Query: 1115 --RENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWG 1172
R NC + + D V + + + + L S+ C+ P V++
Sbjct: 1538 RGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT--A 1595
Query: 1173 PWTQCVLPCNQSSFRQRSADPIRQPADEG-----------RSCPNAVEKEPCNLNKNCYH 1221
+QC C S+RQR P+ + + CP + +C H
Sbjct: 1596 DSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLH 1654
Query: 1222 Y-DYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDL 1261
+ V WS C ++ CG GI R + C+ G S DL
Sbjct: 1655 LATWKVGKWSKCSVT----CGIGIMKRQVKCITKHGLSSDL 1691
Score = 134 bits (338), Expect = 6e-31
Identities = 200/905 (22%), Positives = 331/905 (36%), Gaps = 195/905 (21%)
Query: 654 TTEGKQIRA---RSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-------VYHWQTGP 703
+T K+I R+++ Y+G + NS+ QE + C V++ P
Sbjct: 781 STSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIP 840
Query: 704 WGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICV-RVNVGQVGPKKCPESLRPETVR 762
E + + +++ W G G+Q R + C+ + + V K+C P V
Sbjct: 841 LE---ERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVT 897
Query: 763 PCLLPCKKDCIVTPYSDWTS-CPSSCKEG----DSSIRKQSRHR-VIIQLPANGGRDCTD 816
C DC + + S C S C +G D K S H +Q+ + D
Sbjct: 898 QS---CNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLK 954
Query: 817 PLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQD 876
P +E C C RW +W +C CG G ++R C
Sbjct: 955 PPTQE-LCHGN--CVFTRWHYSEWSQCS--------------RSCGGGERSRESYCMNNF 997
Query: 877 GGQAGIHECLQYAGPVPALTQACQIPCQD-DCQLTSWSKFSSCNGDCGAVRTRKRTL--- 932
G + +EC + L++ + C + C + S++S C CG T++R +
Sbjct: 998 GHRLADNECQE-------LSRVTRENCNEFSCPSWAASEWSECLVTCGK-GTKQRQVWCQ 1049
Query: 933 VGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQP--VGNWSDCILPEGKVEVLLGMKVQGD 990
+ + NS P PC+ + VG W C
Sbjct: 1050 LNVDHLSDGFCNSSTKP---ESLSPCELHTCASWQVGPWGPCTTT--------------- 1091
Query: 991 IKECGQGYRYQAMACYDQNGRLV-ETSRCN--SHGYIEEACII-PCPSDCKL-------- 1038
CG GY+ + + C ++ V E + C+ S ++C++ PC KL
Sbjct: 1092 ---CGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTV 1148
Query: 1039 -----SEW--SNWSRCSKSCGSGVKVRSKWLRE-------KPYNGGRPCPKLDHVNQAQV 1084
++W +W+ CS SCG G + R R+ + Y P P
Sbjct: 1149 LIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPA--------- 1199
Query: 1085 YEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDY 1144
E+ C + C + W WS C + CG G TR+V CM + +++
Sbjct: 1200 -EIWDCFTPCGE--WQAGDWSPCSAS-------CGHGKTTRQVLCMNY-----HQPIDEN 1244
Query: 1145 LCDPEEMPLGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRS 1203
CDPE PL + C L CP P Q S+ + P+ Q ++
Sbjct: 1245 YCDPEVRPLMEQECSLAACPPAHSHFPSSPV--------QPSYYLSTNLPLTQKLEDNE- 1295
Query: 1204 CPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKY 1263
N V N+ + W +C S C G++ R + C +G+S Y
Sbjct: 1296 --NQVVHPSVRGNQ------WRTGPWGSCSSS----CSGGLQHRAVVCQDENGQSAS--Y 1341
Query: 1264 CEALGLEKNWQMNTSCMVEC-PVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG 1322
C+A Q +C P C ++ W ECSQTCG G + R + Q G
Sbjct: 1342 CDAASKPPELQ-------QCGPGPCPQWNYGNWGECSQTCG--GGIKSRLVICQFPNGQI 1392
Query: 1323 RPCPSLMDQSKPCPVKPCY--------RWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
+ +KP V C+ W W+ C A CG+G + R + C+
Sbjct: 1393 LEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSC---SASCGKGRKYREVFCI---- 1445
Query: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDW--SSWSLCQLTCVN 1432
D F + +++ C+ ++ K + S CP W +SW+ C +TC +
Sbjct: 1446 --DQFQRKLEDTNCSQVQ------KPPTHKACRSVRCP------SWKANSWNECSVTCGS 1491
Query: 1433 GEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVW 1492
G +++ +++E+ +Q P + C+ C ++K M S +
Sbjct: 1492 GVQQRDVYCRLKGVGQVVEEMCDQSTRP---CSQRRCWSQDCVQHKGMERGRLNCSTS-- 1546
Query: 1493 CQRSD 1497
C+R D
Sbjct: 1547 CERKD 1551
Score = 134 bits (338), Expect = 6e-31
Identities = 229/1012 (22%), Positives = 359/1012 (35%), Gaps = 266/1012 (26%)
Query: 452 TALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPN-TTQLCHIPCP 510
T +C G +Q R + C+ +++ S +KE P+P+ TQ C+
Sbjct: 860 TKMCQG-LQRRNITCIHKSDH-----SVVSDKECDHL--------PLPSFVTQSCN---- 901
Query: 511 TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAI-PCE 569
T+CE+ W C+ Q G+ L + G V + + + + P
Sbjct: 902 TDCELR----WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPT 957
Query: 570 EPACYD------WKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPI 623
+ C+ W C + CG G + +E C+N+ G + C++
Sbjct: 958 QELCHGNCVFTRWHYSEWSQCS----RSCGGGERSRESYCMNNFGHRLADNECQELSRVT 1013
Query: 624 PVACDA-PCPKDCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNS 680
C+ CP +W S WS C TC GK T+ +Q+ + + + + C +S
Sbjct: 1014 RENCNEFSCP------SWAASEWSECLVTC-GKGTKQRQVWCQLNVDHLSDGF---CNSS 1063
Query: 681 SALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICV 740
+ + + C H C WQ GPWG C TTT C G Q R V CV
Sbjct: 1064 TKPESLSPCELHTCA--SWQVGPWGPC-----------TTT------CGHGYQMRDVKCV 1104
Query: 741 RVNVGQV-GPKKCPESLRPETVRPCLL-PC----KKDCIVTP-----------YSDWTSC 783
V +C E+ RP + C+L PC K + + P + WT C
Sbjct: 1105 NELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPC 1164
Query: 784 PSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC-EAPQACQSY-------RW 835
SC G Q+R+ RD D + +E C P+ + + W
Sbjct: 1165 SVSCGRGT-----QARYVSC--------RDALDRIADESYCAHLPRPAEIWDCFTPCGEW 1211
Query: 836 KTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQ--YAGPV- 892
+ W C CG G+ R + C H+ + Y P
Sbjct: 1212 QAGDWSPCSA--------------SCGHGKTTRQVLCMNY-------HQPIDENYCDPEV 1250
Query: 893 -PALTQACQI-------------PCQDDCQLTS------------------------W-- 912
P + Q C + P Q L++ W
Sbjct: 1251 RPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
Query: 913 SKFSSCNGDCGAVRTRKRTLVGKSKKKEK---CKNSHLYPLIETQYC---PCDKYNAQPV 966
+ SC+ C + R +V + + + C + P E Q C PC ++N
Sbjct: 1311 GPWGSCSSSCSG-GLQHRAVVCQDENGQSASYCDAASKPP--ELQQCGPGPCPQWN---Y 1364
Query: 967 GNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRC---NSHGY 1023
GNW +C + CG G + + + C NG+++E C N
Sbjct: 1365 GNWGECS------------------QTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS 1406
Query: 1024 IEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQ 1083
+ + + CP+D + W+ CS SCG G K R + ++ KL+ N +Q
Sbjct: 1407 VIQCHMHACPADVSWHQ-EPWTSCSASCGKGRKYREVFCIDQFQR------KLEDTNCSQ 1459
Query: 1084 VYEVVPCHSDCNQYL---WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH 1140
V + P H C W W+ C VT CG GVQ R V C G +
Sbjct: 1460 VQKP-PTHKACRSVRCPSWKANSWNECSVT-------CGSGVQQRDVYCRLK---GVGQV 1508
Query: 1141 VEDYLCDPEEMPLGSRVCKLPCPEDCVIS---EWGPWTQCVLPCNQSSFRQR---SADPI 1194
VE+ +CD P R C +DCV E G C C + QR + + I
Sbjct: 1509 VEE-MCDQSTRPCSQRRC---WSQDCVQHKGMERGR-LNCSTSCERKDSHQRMECTDNQI 1563
Query: 1195 RQPAD----------EGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGI 1244
RQ + ++C N PCN Y D S C + CG
Sbjct: 1564 RQVNEIVYNSSTISLTSKNCRNP----PCN-------YIVVTADSSQCANN----CGFSY 1608
Query: 1245 KTRMLDCVRSDG-KSVDLKYCEALGLEKNWQMNTSCMVECPVNC-QLSDWS--PWSECSQ 1300
+ R+ C K L + ++ + +S + +C +C L+ W WS+CS
Sbjct: 1609 RQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSV 1668
Query: 1301 TCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQ 1352
TCG+ + + +T+ G ++ KP K CY ++ C+
Sbjct: 1669 TCGIGIMKRQVKCITK----HGLSSDLCLNHLKPGAQKKCYANDCKSFTTCK 1716
Score = 113 bits (283), Expect = 1e-24
Identities = 174/756 (23%), Positives = 263/756 (34%), Gaps = 172/756 (22%)
Query: 853 DSPGAQEGCGP---GRQARAITC-RKQDGGQAGIHECLQYAGPVPA-LTQACQIPCQDDC 907
D G EGC G Q R ITC K D EC P+P+ +TQ+C DC
Sbjct: 851 DPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHL--PLPSFVTQSCNT----DC 904
Query: 908 QLTSWSKF--SSCNGDCGA------VRTRKRTL-VGKSKKKEK--CKNSHLYPLIETQYC 956
+L W S C+ CG + K ++ G++ + + C + P E +
Sbjct: 905 ELR-WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHG 963
Query: 957 PCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETS 1016
C + WS C + CG G R + C + G + +
Sbjct: 964 NC-VFTRWHYSEWSQCS------------------RSCGGGERSRESYCMNNFGHRLADN 1004
Query: 1017 RCNSHGYI--EEACIIPCPSDCKLSEW--SNWSRCSKSCGSGVKVRSKWLR-EKPYNGGR 1071
C + E CPS W S WS C +CG G K R W + +
Sbjct: 1005 ECQELSRVTRENCNEFSCPS------WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDG 1058
Query: 1072 PCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQ 1131
C E+ C S W PW C T CG G Q R V+C+
Sbjct: 1059 FCNSSTKPESLSPCELHTCAS------WQVGPWGPCTTT-------CGHGYQMRDVKCVN 1105
Query: 1132 NTADGPSEHVEDYLCDPEEMPLGSRVCKL-PCP-----EDCVI--------SEW--GPWT 1175
A S +ED C P + C L PC E ++ ++W G WT
Sbjct: 1106 ELA---SAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWT 1162
Query: 1176 QCVLPCNQSSFRQRSA--DPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQ 1233
C + C + + + + D + + ADE E + C ++ DWS C
Sbjct: 1163 PCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCG--EWQAGDWSPCS 1220
Query: 1234 LSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEA--------------------------- 1266
S CG+G TR + C+ + +D YC+
Sbjct: 1221 AS----CGHGKTTRQVLCMNYH-QPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPV 1275
Query: 1267 ---------LGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQP 1317
L L + + N + +V V PW CS +C +G + R V Q
Sbjct: 1276 QPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC--SGGLQHRAVVCQD 1333
Query: 1318 FQGDGRP---CPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
G S + + C PC +W YG W C CG G ++R + C +G
Sbjct: 1334 ENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGEC---SQTCGGGIKSRLVICQFPNG 1390
Query: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDW--SSWSLCQLTCVN 1432
+++++ C + NK + + CP D W W+ C +C
Sbjct: 1391 ------QILEDHNCEIV------NKPPSVIQCHMHACPADV---SWHQEPWTSCSASCGK 1435
Query: 1433 GEDLGFGGIQVRSRPVIIQELENQHLCPEQMLET-KSCYDGQCYEYKWMASAWKGSS--- 1488
G +V ++LE+ + Q T K+C +C W A++W S
Sbjct: 1436 GRKYR----EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC--PSWKANSWNECSVTC 1489
Query: 1489 ------RTVWCQ-RSDGINVTGGCLVMSQPDADRSC 1517
R V+C+ + G V C ++P + R C
Sbjct: 1490 GSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRC 1525
Score = 109 bits (273), Expect = 2e-23
Identities = 180/757 (23%), Positives = 269/757 (35%), Gaps = 171/757 (22%)
Query: 54 EAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLH-TNCKQAERPNNQQNC- 111
E T W+ GPWG C CG G Q R V C + L T C +A RP+++Q+C
Sbjct: 1073 ELHTCASWQVGPWGPCT-TTCG-HGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCV 1130
Query: 112 FKVCDW-------------HKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREI 158
C + K++ WR G W C + G Q R +
Sbjct: 1131 LTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCS-------------VSCGRGTQARYV 1177
Query: 159 ACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRT 218
+C + D A++ C + P+P C PC + + WS CS +CG G T
Sbjct: 1178 SC-RDALDRIADESYCAHL-PRPAEIWDCFTPCGE----WQAGDWSPCSASCGHG--KTT 1229
Query: 219 RHVVAPPQFGGSGCPNLTEFQVCQSSPCEAE-----ELRYSLHVGPWSTCSMPHSRQVRQ 273
R V+ C N Q + C+ E E SL P + P S V+
Sbjct: 1230 RQVL---------CMNY--HQPIDENYCDPEVRPLMEQECSLAACPPAHSHFP-SSPVQP 1277
Query: 274 ARRRGKN---KEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC 330
+ N ++ +D V P R N+ R + G Q R V+C
Sbjct: 1278 SYYLSTNLPLTQKLEDNENQVVHPSVR------GNQWRTGPWGSCSSSCSGGLQHRAVVC 1331
Query: 331 INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTR 390
++ G++A S+C P Q C C + W CS+TC G +++R
Sbjct: 1332 QDENGQSA--SYCDAASKPPELQQCG-PGPCPQWNYGNWGECSQTC-------GGGIKSR 1381
Query: 391 -TIRQFPIGS--EKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKR 447
I QFP G E E K P + Q A W WT C
Sbjct: 1382 LVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSC------------ 1429
Query: 448 RGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI 507
+A CG G + REV+C+ + L + + KP K C +
Sbjct: 1430 ----SASCGKGRKYREVFCIDQFQRKLEDTNC---SQVQKPPTHKACRS----------V 1472
Query: 508 PCPTECEVSPWSA--WGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEA 565
CP+ W A W C+ C ++ R + + G V C
Sbjct: 1473 RCPS------WKANSWNECSV-TCGSGVQQRDVYCRLKGV------GQVVEEMCDQ--ST 1517
Query: 566 IPCEEPACYDWKAV--------RLG---NCEPDNG---KECGPG--TQVQEVVCINSDGE 609
PC + C+ V RL +CE + EC QV E+V NS
Sbjct: 1518 RPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIV-YNSSTI 1576
Query: 610 EVDRQLCRD--AIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILA 667
+ + CR+ + + A + C +C S + C+ S T + K R R I+
Sbjct: 1577 SLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPS--TKKHKLHRLRPIVY 1634
Query: 668 YAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEAS 727
+E + P+S Q + SC H T W+ G W +C +
Sbjct: 1635 ---QECPV-VPSSQVYQCINSC-LHLAT---WKVGKWSKC-----------------SVT 1669
Query: 728 CSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC 764
C +G+ R+V C+ + + C L+P + C
Sbjct: 1670 CGIGIMKRQVKCITKH--GLSSDLCLNHLKPGAQKKC 1704
Score = 108 bits (270), Expect = 4e-23
Identities = 205/977 (20%), Positives = 316/977 (32%), Gaps = 222/977 (22%)
Query: 146 CIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSE 205
C K +G+Q R I CI K D C++ + Q+C C+ + SE
Sbjct: 859 CTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCE---LRWHVIGKSE 915
Query: 206 CSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSP-----CEAEELRYSLHVGPW 260
CS CG G + H + G + Q P C + H W
Sbjct: 916 CSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEW 975
Query: 261 STCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQ----NRQENKY 316
S CS R N + + D E +EL + R + + +++
Sbjct: 976 SQCSRSCGGGERSRESYCMNNFGHR-----LADNECQELSRVTRENCNEFSCPSWAASEW 1030
Query: 317 WDIQI----GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPC 372
+ + G + R+V C +D FC P + C + C + W PC
Sbjct: 1031 SECLVTCGKGTKQRQVWCQLNVDHLSD-GFCNSSTKPESLSPCEL-HTCASWQVGPWGPC 1088
Query: 373 SKTCHDMVSPAGTRVR-TRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYG----- 426
+ TC G ++R + + + ++ E P Q + PC+
Sbjct: 1089 TTTCGH-----GYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETA 1143
Query: 427 ------------WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLL 474
WR WT C V CG G Q R V C A + +
Sbjct: 1144 LLPTVLIKKMAQWRHGSWTPCSVS----------------CGRGTQARYVSCRDALDRI- 1186
Query: 475 SQLSTHKNKEASKPMDLKLCTG-PIPNTTQLCHIPCPTECEVSPWSA--WGPCTYENCND 531
D C P P C PC W A W PC+ +
Sbjct: 1187 --------------ADESYCAHLPRPAEIWDCFTPC------GEWQAGDWSPCSASCGHG 1226
Query: 532 QQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDN--- 588
+ ++ + + +E C E P E C L C P +
Sbjct: 1227 KTTRQVLCMNYHQPIDE--------NYCDP--EVRPLMEQEC------SLAACPPAHSHF 1270
Query: 589 -GKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWST--WSS 645
P + + + E+ + Q+ ++ + W T W S
Sbjct: 1271 PSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG---------------NQWRTGPWGS 1315
Query: 646 CSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWG 705
CS +CSG G Q RA G+ C +S E++ C PC W G WG
Sbjct: 1316 CSSSCSG----GLQHRAVVCQDENGQSASY-CDAASKPPELQQCGPGPCP--QWNYGNWG 1368
Query: 706 QCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCL 765
+C + +C G+++R VIC N + C +P +V C
Sbjct: 1369 ECSQ-----------------TCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCH 1411
Query: 766 LPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACE 825
+ + WTSC +SC +G ++R + + D E+ C
Sbjct: 1412 MHACPADVSWHQEPWTSCSASCGKG-------RKYREVFCI------DQFQRKLEDTNCS 1458
Query: 826 APQ------ACQSYR---WKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQD 876
Q AC+S R WK + W C + CG G Q R + CR +
Sbjct: 1459 QVQKPPTHKACRSVRCPSWKANSWNECSVT--------------CGSGVQQRDVYCRLKG 1504
Query: 877 GGQAGIHECLQYAGPVPALTQACQIPC-QDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGK 935
GQ C Q P Q C DC + N C RK
Sbjct: 1505 VGQVVEEMCDQSTRP------CSQRRCWSQDCVQHKGMERGRLN--CSTSCERK-----D 1551
Query: 936 SKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWS-DCILPEGKVEVLLGMKVQGDIKEC 994
S ++ +C ++ + + E YN+ + S +C P V+ Q C
Sbjct: 1552 SHQRMECTDNQIRQVNEI------VYNSSTISLTSKNCRNPPCNYIVVTADSSQ-CANNC 1604
Query: 995 GQGYRYQAMACYDQNGRLVETSRCNSHG----YIEEACIIP------CPSDC-KLSEW-- 1041
G YR + C + + T + H +E ++P C + C L+ W
Sbjct: 1605 GFSYRQRITYCTE----IPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
Query: 1042 SNWSRCSKSCGSGVKVR 1058
WS+CS +CG G+ R
Sbjct: 1661 GKWSKCSVTCGIGIMKR 1677
Score = 78.6 bits (192), Expect = 5e-14
Identities = 125/549 (22%), Positives = 195/549 (35%), Gaps = 110/549 (20%)
Query: 1088 VPCHSDCNQYLWVTE-PWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH--VEDY 1144
+P + + W PW C + C +G+Q R + C+ S+H V D
Sbjct: 839 IPLEERSDMFTWDPYGPWEGCT-------KMC-QGLQRRNITCIHK-----SDHSVVSDK 885
Query: 1145 LCDPEEMPLGSRVCKLPCPEDCVISEWGPW-----TQCVLPCNQSSFRQRSADPIRQPAD 1199
CD +PL S V + C DC + W ++C C Q +R ++
Sbjct: 886 ECD--HLPLPSFVTQ-SCNTDCELR----WHVIGKSECSSQCGQG-YRTLDIHCMKYSIH 937
Query: 1200 EGRS-------CPNAVEKEPCNL-NKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDC 1251
EG++ C + ++ L + NC ++ ++WS C S CG G ++R C
Sbjct: 938 EGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRS----CGGGERSRESYC 993
Query: 1252 VRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDW--SPWSECSQTCGLTGKMI 1309
+ + G + C+ L N CP W S WSEC TCG K
Sbjct: 994 MNNFGHRLADNECQELSRVTRENCNE---FSCP------SWAASEWSECLVTCG---KGT 1041
Query: 1310 RRRTVTQPFQ----GDGRPCPSLMDQS-KPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRT 1364
++R V DG S +S PC + C WQ G W PC CG G +
Sbjct: 1042 KQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPC---TTTCGHGYQM 1098
Query: 1365 RNISC-------VVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYL 1417
R++ C V+ D + S+ D + C ++ + E+ P +
Sbjct: 1099 RDVKCVNELASAVLEDTECHEASRPSDRQSC-----VLTPCSFISKLETALLPTVLIKKM 1153
Query: 1418 KDW--SSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPE--QMLETKSCYDGQ 1473
W SW+ C ++C G + + R + + ++ C + E C+
Sbjct: 1154 AQWRHGSWTPCSVSCGRGTQARY--VSCRD---ALDRIADESYCAHLPRPAEIWDCFT-P 1207
Query: 1474 CYEYKWMASAWKGSSRTVWCQRSDGINVTGG---CLVMSQPDADRSCNPPCSQPHSYCSE 1530
C E W A W C S G T C+ QP + C+P E
Sbjct: 1208 CGE--WQAGDWSP------CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLME--QE 1257
Query: 1531 TKTCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRG 1590
C ++ SS + + +ED V VHP+ RG
Sbjct: 1258 CSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQV-----VHPSV-------RG 1305
Query: 1591 RTWFLQPFG 1599
W P+G
Sbjct: 1306 NQWRTGPWG 1314
Score = 39.3 bits (90), Expect = 0.032
Identities = 51/213 (23%), Positives = 71/213 (33%), Gaps = 54/213 (25%)
Query: 506 HIPCPT-ECEVSPWSAWGPCTY----ENCNDQQGKKGFKLRKRRITNEPTG--GSGVTGN 558
H+ P +SPWS W C+ E + G+ I N P+ GS GN
Sbjct: 428 HVMAPALSFHMSPWS-WSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGN 486
Query: 559 -------------CPHLLEAIPCEEPACYDWKAVRLG----NCEPDNGKECGPGTQVQEV 601
CPH+ C C + + G + P +G +CGPG +
Sbjct: 487 KQCELAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHG 543
Query: 602 VCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIR 661
+C+N + E P + W +SSCS TC G G +
Sbjct: 544 LCVNKETE--------------------TRPVNGEWGPWEPYSSCSRTCGG----GIESA 579
Query: 662 ARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
R GG C + RSCN C
Sbjct: 580 TRRCNRPEPRNGGNYCVGRR--MKFRSCNTDSC 610
Score = 35.4 bits (80), Expect = 0.46
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 203 WSECSKTCGSGLQHRTRHVVAP-PQFGGSGC-PNLTEFQVCQSSPC 246
+S CS+TCG G++ TR P P+ GG+ C +F+ C + C
Sbjct: 565 YSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Score = 33.9 bits (76), Expect = 1.3
Identities = 17/57 (29%), Positives = 24/57 (42%)
Query: 1284 PVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
PVN + W P+S CS+TCG + RR + G C + + C C
Sbjct: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Score = 33.1 bits (74), Expect = 2.3
Identities = 14/42 (33%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Query: 1033 PSDCKLSEWSNWSRCSKSCGSGVKVRSKWL-REKPYNGGRPC 1073
P + + W +S CS++CG G++ ++ R +P NGG C
Sbjct: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 138 bits (348), Expect = 4e-32
Identities = 349/1654 (21%), Positives = 523/1654 (31%), Gaps = 448/1654 (27%)
Query: 191 CQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPP-QFGGSGCPNLT-EFQVCQSSPCEA 248
C C S ++ WS CS +C G++ R R APP FGG+ C T E + C PC
Sbjct: 2982 CPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPG 3041
Query: 249 EELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNR 308
+ GPWS CS+P R R RG ++ + + G++ P A +
Sbjct: 3042 PGGEW----GPWSPCSVPCGGGYRN-RTRGSSRSLMEFSTCGLQ-PCAGPV-------PG 3088
Query: 309 QNRQENKYWDIQIG-YQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWS 367
++ ++ D G E+ T + + + CV T++C
Sbjct: 3089 MCPRDKQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDC------ 3142
Query: 368 EWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEF--EEKEPCLSQGDGVVPCATY 425
PC+ H + P T VR G C + E EP S
Sbjct: 3143 ---PCAHEGH-LYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSP---------- 3188
Query: 426 GWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEA 485
W T W++C +A CG R +C ++ + S ++
Sbjct: 3189 -W--TPWSQC----------------SASCGPARCHRHRFCARSPSAVPSTVAPLPLPAT 3229
Query: 486 SKPMDLKLCTGPIPNTTQLCHIPCPTE-CE-VSPWSAWGPCTYENCNDQQGKKGFKLRKR 543
P LC+GP + PC + C+ W WGP + +C+ G G + R R
Sbjct: 3230 PTP----LCSGP-----EAEEEPCLLQGCDRAGGWGPWGP--WSHCSRSCG-GGLRSRTR 3277
Query: 544 RITNEPTGGSGVTGNCP----HLLEAIPCEEPACYDWKAVRLGNCEPDNGKECG------ 593
P G G P + +A+PC C + C P + C
Sbjct: 3278 ACDQPPPQGLGDYCEGPRAQGEVCQALPCPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCV 3337
Query: 594 ----PGTQVQEVVCINSDGE---EVDRQLCRD----------AIFPIPVAC--------- 627
PG ++S+G + C D A P C
Sbjct: 3338 WRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGR 3397
Query: 628 ----DAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCP----N 679
D PCP WS W+ CS C G+T + R+R+ + GG C
Sbjct: 3398 LNCTDLPCPVPGGWCPWSEWTMCSQPCRGQT----RSRSRACACPTPQHGGAPCTGEAGE 3453
Query: 680 SSALQEVRSCNEHPCTVYHWQTGPWG------QCIEDTSVS-SFNTTTTWNGEASCSVGM 732
+ A + +C + GPWG C+ + S + + T G C G
Sbjct: 3454 AGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCP-GN 3512
Query: 733 QTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDS 792
T+ C Q +C + +++ PC PC + C S S C+ G
Sbjct: 3513 HTQSRPC------QENSTQCTDCGGGQSLHPCGQPCPRSC------QDLSPGSVCQPGSV 3560
Query: 793 SIRKQSRHRVIIQLPANGGRDC-TDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQ 851
+ P G C L ++ C P C RCQ P ++
Sbjct: 3561 GCQ-----------PTCG---CPLGQLSQDGLCVPPAHC-----------RCQYQPGAM- 3594
Query: 852 QDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLT 910
G E +R + + G+ C V + Q ++P C D +
Sbjct: 3595 ----GIPENQSRSAGSRFSSWESLEPGEVVTGPC-DNCTCVAGILQCQEVPDCPDPGVWS 3649
Query: 911 SWSKFSSCNGDCGA---VRTRK-------------RTLVGKSKKKEKCKNSHLYPLIET- 953
SW + C+ CG +R+R+ RT + ++ C LY +
Sbjct: 3650 SWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPG 3709
Query: 954 QYCPCD-KYNAQPVGNWSD-----CILPEGKVEVLLGMKVQGD-------IKECGQ--GY 998
+ CP + Q VG +S+ C PEG + L + ++E G G
Sbjct: 3710 EGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAWLLQELGATIGD 3769
Query: 999 RYQAMACYDQ--NGRLVETSRCN---SHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGS 1053
Q + D+ +G+ + TS N +HG + + +D WS W CS+SCG
Sbjct: 3770 PGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADGGFGPWSPWGPCSRSCGG 3829
Query: 1054 -GVKVRSK-WLREKPYNGGRPC--PKLDHVNQAQVYEVVPCHS-DCNQYLWVT------- 1101
G + RS+ + P G+ C P+ D + C S DC T
Sbjct: 3830 LGTRTRSRQCVLTMPTLSGQGCRGPRQD----------LECPSPDCPGAEGSTVEPVTGL 3879
Query: 1102 ----EPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRV 1157
PWS + + ++R C+ N G PL R
Sbjct: 3880 PGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGD--------------PLQERP 3925
Query: 1158 CKLP-------CP------EDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSC 1204
C LP CP +C + W PW C C +QR R P G C
Sbjct: 3926 CNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVG--QQRRLRAYRPPGPGGHWC 3983
Query: 1205 PNAV----EKEPCNLNKNCYHYDYN-VTDWSTCQLSEKAVCGNGIKTRMLDC-------- 1251
PN + E+ CNL ++ + WS C S CG G R C
Sbjct: 3984 PNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRS----CGGGQSLRSRSCSSPPSKNG 4039
Query: 1252 -VRSDGKSVDLKYCEALGLEKNWQMN---TSCMVECPVNC-------------------- 1287
G+ + C + E +C CP C
Sbjct: 4040 GAPCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCR 4099
Query: 1288 -----------------------QLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRP 1324
Q W+P S+ C + + T +P
Sbjct: 4100 CPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCT------AQP 4153
Query: 1325 CP-------SLMDQSKPCPVKPCYRWQY--------GQWSP-CQVQEAQ----------- 1357
CP S PC R Q G W+P C+ +++Q
Sbjct: 4154 CPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPP 4213
Query: 1358 -CGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIID----------------GNKN 1400
C +GTR+R + G S + C D E + G N
Sbjct: 4214 LCLQGTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGN 4273
Query: 1401 MVLEESC--------------------SQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGG 1440
V +C QPCPG W W C +C G G
Sbjct: 4274 QVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPGLLEACSWGPWGPCSRSCGPGLASRSG- 4332
Query: 1441 IQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYE----------------------YK 1478
S P ++ + + L+T+ CY G C E Y+
Sbjct: 4333 ----SCPCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRCSCRVLVQQRYR 4388
Query: 1479 WMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPP-----CSQP--------- 1524
A +G+ C R DG CL+ + ++ SC PP C P
Sbjct: 4389 HQGPASRGARAGAPCTRLDG--HFRPCLISN--CSEDSCTPPFEFHACGSPCAGLCATHL 4444
Query: 1525 -HSYCSETKT----CHCEEGYTEVMSSNSTLEQC 1553
H C + C+C +G E E+C
Sbjct: 4445 SHQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEEC 4478
Score = 122 bits (306), Expect = 3e-27
Identities = 246/1091 (22%), Positives = 364/1091 (33%), Gaps = 263/1091 (24%)
Query: 366 WSEWSPCSKTCHDMVSPAGTRVRTRT-IRQFPIGS---EKEC--PEFEEKEPCLSQGDGV 419
WS WSPCS++C D PA R RTR + +G E+ C P E C G G
Sbjct: 3886 WSSWSPCSRSCTDPARPAW-RSRTRLCLANCTMGDPLQERPCNLPSCTELPVCPGPGCGA 3944
Query: 420 VPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLST 479
C+ W W C + QQ + R + GG +C N+L+
Sbjct: 3945 GNCSWTSW--APWEPCSRSCGVGQQRRLRAYRPPGPGGH------WC----PNILTAYQE 3992
Query: 480 HKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGF 538
+ C++ CP S WS W C D+ G
Sbjct: 3993 RR----------------------FCNLRACPVPGGWSRWSPWSWC------DRSCGGGQ 4024
Query: 539 KLRKRRITNEPT--GGSGVTGN---------------CPHLLEAIPC------------E 569
LR R ++ P+ GG+ G CP +E + C E
Sbjct: 4025 SLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQE 4084
Query: 570 EPACYDWKAVRLG-NCEPDNGKECGPGTQVQEVVCINSDGEE-----VDRQLCRDAIFPI 623
C D + + G C + ++ G + C ++ G + C +
Sbjct: 4085 GIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQA 4144
Query: 624 -PVACDA-PCPKD--CVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPN 679
++C A PCP C S WS WS CSH+C + G+Q R + G P
Sbjct: 4145 GQLSCTAQPCPPPTHCAWSHWSAWSPCSHSCGPR---GQQSR------FRSSTSGSWAPE 4195
Query: 680 SSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVIC 739
Q PC P C G S ++G + C
Sbjct: 4196 CREEQS----QSQPC--------PQPSC----------PPLCLQGTRSRTLGDSWLQGEC 4233
Query: 740 VRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSR 799
R S PE V C T +S W+ CP SC G+ + R
Sbjct: 4234 QRC------------SCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACR 4281
Query: 800 HRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQE 859
P + C P + + P ++ W PW
Sbjct: 4282 AAA----PHHRSPPCLGPDTQTRQQPCPGLLEACSWG----------PWGP------CSR 4321
Query: 860 GCGPGRQARAITCRKQDGGQAGIHECLQY-AGP------VPALTQACQI-PCQDDCQLTS 911
CGPG +R+ +C CL A P + TQ C PC ++C +S
Sbjct: 4322 SCGPGLASRSGSC-----------PCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSS 4370
Query: 912 WSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCK------NSHLYPLIETQYCPCDKYNAQP 965
WS ++ C+ C + ++ G + + + + H P + + C + + P
Sbjct: 4371 WSSWTRCS--CRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISN---CSEDSCTP 4425
Query: 966 VGNWSDCILP-EGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNS-HGY 1023
+ C P G L ++ D+ C G Y +Q G + CN H
Sbjct: 4426 PFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGC-YCPKGLLEQAGGCIPPEECNCWHTS 4484
Query: 1024 IEEACIIPCPSD-----CKLSEWSNWS-RCSKSCGSGVKVRSKWLREKPYNGGRPCPKLD 1077
A + P D CK E C+ G+ S+W P P L
Sbjct: 4485 AAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGPCLPPSALA 4544
Query: 1078 HVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGP 1137
++ + E W+ +P + + Q R C+ + A G
Sbjct: 4545 PASRTALEEH-----------WLRDPTGLSPTLAPLLASE-----QHRHRLCL-DPATGR 4587
Query: 1138 SEHVEDYLCDPEEMPLGS-RVCKLP--CPEDCVISEWGPWTQCVLPCNQSSFRQR----- 1189
+LC PL R+C P CP+ C S WGPW+ C +PC+ FR R
Sbjct: 4588 PWTGAPHLCTA---PLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCS-GGFRLRWREAE 4643
Query: 1190 ------SADPIRQPADEGRSCPNAVEKE---PCNLNKNCYHYDYNVTDWSTCQLSEKAVC 1240
+P Q + G CP ++ + C H ++ D C + C
Sbjct: 4644 ALCGGGCREPWAQESCNGGPCPECEAQDTVFTLDCANQCPHSCADLWDRVQCL---QGPC 4700
Query: 1241 GNGIKTRMLDCVRSDGKSVDLKYCEALGL---EKNWQM-----------NTSCM------ 1280
G + V+ DG+ V + C GL +W++ N +C+
Sbjct: 4701 RPGCRCPPGQLVQ-DGRCVPISSCRC-GLPSANASWELAPAQAVQLDCQNCTCVNESLVC 4758
Query: 1281 --VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG-RPCPSL-MDQSKPCP 1336
ECPV L WS WS CS CG G M R RT G G PC + +Q + C
Sbjct: 4759 PHQECPV---LGPWSAWSSCSAPCG-GGTMERHRTCE---GGPGVAPCQAQDTEQRQECN 4811
Query: 1337 VKPCYRWQYGQ 1347
++PC GQ
Sbjct: 4812 LQPCPECPPGQ 4822
Score = 118 bits (295), Expect = 5e-26
Identities = 320/1508 (21%), Positives = 471/1508 (31%), Gaps = 395/1508 (26%)
Query: 74 CGPGGIQTRAVWCAHVEGWTTLHTNCKQAER-----PNNQ----------------QNCF 112
C PGG W A W +C R P+N Q C
Sbjct: 2707 CQPGGCPLPCGWSAW-SSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCH 2765
Query: 113 KVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQK-DKDIPAED 171
VC E++ W PW S+S P G G + R C D P +
Sbjct: 2766 TVCG--TEVFGWT--PWTSWSSC-SQSCLAP----GGGPGWRSRSRLCPSPGDSSCPGDA 2816
Query: 172 IICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHV--VAPPQFGG 229
+ +P C +P I ++ WS CS C G+Q R R +AP G
Sbjct: 2817 T-----QEEPCSPPVCPVPS----IWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP---GD 2864
Query: 230 SGCPN-LTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRS 288
+ CP ++ + C + PC A+ L C R +G E +
Sbjct: 2865 TTCPGPHSQTRDCNTQPCTAQCPENMLFRSA-EQCHQEGGPCPRLCLTQGPGIECTGFCA 2923
Query: 289 KGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKL 348
G P L Q + G R C N T C K+
Sbjct: 2924 PGCTCPPGLFLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCT--------CVSGKM 2975
Query: 349 PMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPI---GSEKECPE 405
T + C + C S W+ WS CS +C+ G R R R P G+E + P
Sbjct: 2976 ACTSERCPVA--CGWSPWTLWSLCSCSCN-----VGIRRRFRAGTAPPAAFGGAECQGPT 3028
Query: 406 FEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVY 465
E E C + PC G W+ C V CGGG + R
Sbjct: 3029 M-EAEFC-----SLRPCPGPGGEWGPWSPCSVP----------------CGGGYRNR--- 3063
Query: 466 CVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPW--SAWGP 523
+ + L + ST L+ C GP+P CP + W A GP
Sbjct: 3064 -TRGSSRSLMEFST---------CGLQPCAGPVPGM-------CPRD---KQWLDCAQGP 3103
Query: 524 CTYENCNDQQGKKGFKLRKRRITNEPTGGSGV------TGNCP-----HLLE-----AIP 567
+C + +G + P+G + T +CP HL P
Sbjct: 3104 A---SCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRP 3160
Query: 568 CEEPACYDWKAVRLGNCEPDNGK--------------ECGPGTQVQEVVCINSDGEEVDR 613
CE +C + G+ CGP + C S
Sbjct: 3161 CENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHRFCARSP------ 3214
Query: 614 QLCRDAIFPIPV------ACDAPCPKD--CVL---------STWSTWSSCSHTCSGKTTE 656
+ P+P+ C P ++ C+L W WS CS +C G
Sbjct: 3215 SAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSCGG---- 3270
Query: 657 GKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHW---QTGPWGQCIEDTSV 713
G + R R+ + G C A EV C PC V + + + C
Sbjct: 3271 GLRSRTRACDQPPPQGLGDYCEGPRAQGEV--CQALPCPVTNCTAIEGAEYSPCGPPCPR 3328
Query: 714 SSFNTT-TTWNGEASC----SVGMQTRKVICVRVNVGQVGPKKCPESL------------ 756
S + W + C + + ICV Q G C + L
Sbjct: 3329 SCDDLVHCVWRCQPGCYCPPGQVLSSNGAICV-----QPGHCSCLDLLTGQRHHPGARLA 3383
Query: 757 RPETVRPCL----------LPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQL 806
RP+ C LPC P+S+WT C C+ R +SR
Sbjct: 3384 RPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCR---GQTRSRSR-ACACPT 3439
Query: 807 PANGGRDCTDPLYEEKACEAPQACQSY-------RW--------------KTHKWRRCQL 845
P +GG CT E A +AC SY W ++H+ R C
Sbjct: 3440 PQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSR 3499
Query: 846 VPWSVQQDSPGAQEGCGPGRQARAITCRKQD------GGQAGIHECLQYAGPVPALTQAC 899
P +P C PG ++ C++ GG +H C Q C
Sbjct: 3500 PP------TPEGGRPC-PGNHTQSRPCQENSTQCTDCGGGQSLHPC----------GQPC 3542
Query: 900 QIPCQD-----DCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQ 954
CQD CQ S C CG +G+ + C +
Sbjct: 3543 PRSCQDLSPGSVCQPGS----VGCQPTCGCP-------LGQLSQDGLC--------VPPA 3583
Query: 955 YCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVE 1014
+C C +Y +G +PE + G R+ + + V
Sbjct: 3584 HCRC-QYQPGAMG------IPENQSR--------------SAGSRFSSWESLEPGE--VV 3620
Query: 1015 TSRCNS----HGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGG 1070
T C++ G ++ + CP S W W CS SCG G ++RS+ P G
Sbjct: 3621 TGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGP 3680
Query: 1071 RPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRE-------------N 1117
+ QV C + +P C + ++ + +
Sbjct: 3681 ---ARQSRTCSTQVCREAGC--PAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCH 3735
Query: 1118 CGEGVQTRKVRCMQN---------------TADGPSEHV--EDYLCDPEEMPLGSRVC-- 1158
C EG ++ C+Q T P + + D L + + C
Sbjct: 3736 CPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSC 3795
Query: 1159 ---KLPCP-EDCVISE-----WGPWTQCVLPCNQSSFRQRSAD-PIRQPADEGRSCPNAV 1208
KL C +DC ++ W PW C C R RS + P G+ C
Sbjct: 3796 AHGKLSCSLDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPR 3855
Query: 1209 EKEPCNLNKNCYHYDYNVTD--------------WSTCQLSEKAVCGNGIKTRMLDCVRS 1254
+ C + +C + + + WS C S ++R C
Sbjct: 3856 QDLECP-SPDCPGAEGSTVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLC--- 3911
Query: 1255 DGKSVDLKYCEALGLEKNWQMNTSCMVECPV---------NCQLSDWSPWSECSQTCGLT 1305
L C + N E PV NC + W+PW CS++CG+
Sbjct: 3912 ------LANCTMGDPLQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGV- 3964
Query: 1306 GKMIRRRTVTQPFQGDGRPCPSLM---DQSKPCPVKPC-YRWQYGQWSPCQVQEAQCGEG 1361
G+ R R P G G CP+++ + + C ++ C + +WSP + CG G
Sbjct: 3965 GQQRRLRAYRPPGPG-GHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGG 4023
Query: 1362 TRTRNISC 1369
R+ SC
Sbjct: 4024 QSLRSRSC 4031
Score = 118 bits (295), Expect = 5e-26
Identities = 300/1359 (22%), Positives = 421/1359 (30%), Gaps = 397/1359 (29%)
Query: 334 TGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIR 393
TG+A + Q + ++ +C + + W WSPC DM R R +
Sbjct: 3448 TGEAGEAGAQHQREACPSYATCPV--DGAWGPWGPWSPC-----DMCLGQSHRSRACSRP 3500
Query: 394 QFPIGSEKECP-EFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGN-- 450
P G + CP + PC C G ++ C S QD G+
Sbjct: 3501 PTPEGG-RPCPGNHTQSRPCQENSTQCTDCG--GGQSLH--PCGQPCPRSCQDLSPGSVC 3555
Query: 451 --------QTALCGGGIQTREVYCVQA---------------NENLLSQLSTHKNKEASK 487
T C G +++ CV S S + E+ +
Sbjct: 3556 QPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLE 3615
Query: 488 PMDLKLCTGPIPNTTQLCHIPCPTECEVSP-------WSAWGPCTYENCNDQQGKKGFKL 540
P ++ TGP N T + I +C+ P WS+WGP +E+C+ G G +L
Sbjct: 3616 PGEV--VTGPCDNCTCVAGI---LQCQEVPDCPDPGVWSSWGP--WEDCSVSCGG-GEQL 3667
Query: 541 RKRRITNEPTGG------------------------------SGVTGNCPHLLEAIPCEE 570
R RR P G G +C H+ + + C
Sbjct: 3668 RSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFS 3727
Query: 571 PACYD-------------------------WKAVRLGNCEPDNGKECGPGTQVQ------ 599
C + W LG D G+ GPG ++
Sbjct: 3728 EGCEEGCHCPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLR 3787
Query: 600 -----------EVVCINSDGEEVD---------------------RQLCRDAIFPIPV-- 625
++ C D E D R R + +P
Sbjct: 3788 TSCGNCSCAHGKLSCSLDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLS 3847
Query: 626 --ACDAP-----CPK-DCV----------------LSTWSTWSSCSHTCSGKTTEGKQIR 661
C P CP DC WS+WS CS +C+ + R
Sbjct: 3848 GQGCRGPRQDLECPSPDCPGAEGSTVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSR 3907
Query: 662 ARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPW---GQCIEDTSVSSFNT 718
R LA C LQE R CN CT GP G C S+ +
Sbjct: 3908 TRLCLA--------NCTMGDPLQE-RPCNLPSCTELPVCPGPGCGAGNC-------SWTS 3951
Query: 719 TTTWNG-EASCSVGMQTRKVICVRVNVGQVGPKKCPESLRP-ETVRPC-LLPCKKDCIVT 775
W SC VG Q R G CP L + R C L C +
Sbjct: 3952 WAPWEPCSRSCGVGQQRR---LRAYRPPGPGGHWCPNILTAYQERRFCNLRACPVPGGWS 4008
Query: 776 PYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPA-NGGRDCTDPLYEEKACE-------AP 827
+S W+ C SC G S R R P+ NGG C ++ + C P
Sbjct: 4009 RWSPWSWCDRSCGGGQS-----LRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCP 4063
Query: 828 QACQSYRWKTHKWRRC-QLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGG-------- 878
+ RRC L V QD Q+GC + + +QDGG
Sbjct: 4064 AGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGS-----LEQDGGCVPIGHCD 4118
Query: 879 ---------------QAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCG 923
Q + C AG + Q C P C + WS +S C+ CG
Sbjct: 4119 CTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTH--CAWSHWSAWSPCSHSCG 4176
Query: 924 --AVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEV 981
++R R+ S E C+ ++Q PC + + P+ C+ +G
Sbjct: 4177 PRGQQSRFRSSTSGSWAPE-CREE------QSQSQPCPQPSCPPL-----CL--QGTRSR 4222
Query: 982 LLGMK-VQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSE 1040
LG +QG+ + C C G I E P L
Sbjct: 4223 TLGDSWLQGECQRCS----------------------CTPEGVICEDTECAVPEAWTL-- 4258
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLR-EKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLW 1099
WS+WS C SCG G +VR++ R P++ PC D + Q PC W
Sbjct: 4259 WSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQ-----PCPGLLEACSW 4313
Query: 1100 VTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC- 1158
PW C +CG G+ +R C A D C+ + L ++ C
Sbjct: 4314 --GPWGPCS-------RSCGPGLASRSGSCPCLMAKA------DPTCNSTFLHLDTQGCY 4358
Query: 1159 KLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA-VEKEPCNLNK 1217
PCPE+CV S W WT+C R R P + A G C PC L
Sbjct: 4359 SGPCPEECVWSSWSSWTRCSCRVLVQQ-RYRHQGPASRGARAGAPCTRLDGHFRPC-LIS 4416
Query: 1218 NC-----------------------YHYDYNV-TDWSTCQLSEKAVCGNGIKTRMLDCVR 1253
NC H + + D CQ C G+ + C+
Sbjct: 4417 NCSEDSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQ--PGCYCPKGLLEQAGGCIP 4474
Query: 1254 SDGKSVDLKYCEALG----LEKNWQMNTSCM-VEC--------PVNCQ----LSDWSPWS 1296
+ + + A G L ++ C EC CQ LS+WS WS
Sbjct: 4475 PE--ECNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWS 4532
Query: 1297 EC----------------------------SQTCG--LTGKMIRRRTVTQPFQG---DGR 1323
C S T L + R R P G G
Sbjct: 4533 PCGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRPWTGA 4592
Query: 1324 P--CPSLMDQSKPCP-----VKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSA 1376
P C + + Q + CP C +G WSPCQV G R R + G
Sbjct: 4593 PHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQV-PCSGGFRLRWREAEALCGGGCR 4651
Query: 1377 DDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDC 1415
+ ++ +E C ++ V C+ CP C
Sbjct: 4652 EPWA----QESCNGGPCPECEAQDTVFTLDCANQCPHSC 4686
Score = 116 bits (290), Expect = 2e-25
Identities = 278/1284 (21%), Positives = 405/1284 (31%), Gaps = 286/1284 (22%)
Query: 353 QSCVITKECQVSE----WSEWSPCSKTCHDMVSPAGTRVRTRT-IRQFPIGSEKECP-EF 406
QSC + + C V+ W W PCS +C G + R R+ + P CP
Sbjct: 2545 QSCFV-QACPVAGAWAMWEAWGPCSVSCG-----GGHQSRQRSCVDPPPKNGGAPCPGAS 2598
Query: 407 EEKEPCLSQGDGVVPCA-----TYGWRTTEWTECR-----------VDPLLSQQDKRRGN 450
+E+ PC G+ PC+ G C+ +DP ++
Sbjct: 2599 QERAPC-----GLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCV 2653
Query: 451 QTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP-- 508
+ C G+ + C+ +E L + K L C+ + +L P
Sbjct: 2654 EGCRCPPGLLLHDTRCLPLSE--CPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGG 2711
Query: 509 CPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPT--GGSGVTGNCPHLLEAI 566
CP C S WS+W PC D+ G + R R +N P GG+ G+ L
Sbjct: 2712 CPLPCGWSAWSSWAPC------DRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCH 2765
Query: 567 PCEEPACYDWKA-VRLGNCEPDNGKEC-----GPGTQVQEVVCINSDGEEVDRQLCRDAI 620
+ W +C + C GPG + + +C + D DA
Sbjct: 2766 TVCGTEVFGWTPWTSWSSCS----QSCLAPGGGPGWRSRSRLCPSPG----DSSCPGDAT 2817
Query: 621 FPIPVACDAP-CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPN 679
P C P CP + W+ WS+CS C G G Q R RS + A G CP
Sbjct: 2818 QEEP--CSPPVCPVPSIWGLWAPWSTCSAPCDG----GIQTRGRSCSSLA--PGDTTCPG 2869
Query: 680 SSALQEVRSCNEHPCTVY-------------HWQTGPWGQ-CIEDTSVSSFNTTTTWNGE 725
+ + R CN PCT H + GP + C+ T T
Sbjct: 2870 PHS--QTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCL--TQGPGIECTGFCAPG 2925
Query: 726 ASCSVGMQTRKVICVRVNVGQVGPKKCPESL-----------RPETVRPCLLP------- 767
+C G+ C+ + +CP L R ++ C
Sbjct: 2926 CTCPPGLFLHNASCLPRS-------QCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACT 2978
Query: 768 ---CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPAN-GGRDCTDPLYEEKA 823
C C +P++ W+ C SC G IR+ R R PA GG +C P E +
Sbjct: 2979 SERCPVACGWSPWTLWSLCSCSCNVG---IRR--RFRAGTAPPAAFGGAECQGPTMEAEF 3033
Query: 824 CEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPG--RQARAITCRKQDGGQAG 881
C + C + W C VP CG G + R + + G
Sbjct: 3034 CSL-RPCPGPGGEWGPWSPCS-VP-------------CGGGYRNRTRGSSRSLMEFSTCG 3078
Query: 882 IHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRT---------- 931
+ C AGPVP + C D Q ++ + + A R +T
Sbjct: 3079 LQPC---AGPVPGM-------CPRDKQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSG 3128
Query: 932 ---LVGKSKKKEKCK---NSHLYPLIETQYCPCDKYNAQP--VGNWSDCILPEGKVEVLL 983
L + C HLYP T PC+ + + N S EG+
Sbjct: 3129 MLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSP 3188
Query: 984 GMKVQGDIKECGQGYRYQAMACYDQNGRL-----------VETSRCNSHGYIEEACIIP- 1031
CG ++ C + T C+ EE C++
Sbjct: 3189 WTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQG 3248
Query: 1032 CPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNG----------------GRPCPK 1075
C W WS CS+SCG G++ R++ + P G PCP
Sbjct: 3249 CDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCP- 3307
Query: 1076 LDHVNQAQVYEVVPCHSDCNQ-------YLWVTEPWSICKVTFVNMRENCGEGVQTRKVR 1128
+ + + E PC C + +W +P C V + N VQ
Sbjct: 3308 VTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQV-LSSNGAICVQPGHCS 3366
Query: 1129 CMQNTADGPSEHVEDYLCDPEEMPLGSRVC----------KLPCPEDCVISEWGPWTQCV 1178
C+ + G H L P+ G C LPCP W WT C
Sbjct: 3367 CL-DLLTGQRHHPGARLARPD----GCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCS 3421
Query: 1179 LPCNQSSFRQRSADPIRQPADEGRSCP-NAVEKEPCNLNKNCYHYDYNVTD--------W 1229
PC + + A P G C A E + + C Y D W
Sbjct: 3422 QPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPW 3481
Query: 1230 STCQLSEKAVCGNGIKTRMLDCVR----SDGKSVDLKYCEALGLEKNWQMNTS------- 1278
S C + G R C R G+ + ++ ++N T
Sbjct: 3482 SPCDMC------LGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSL 3535
Query: 1279 --CMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCP-SLMDQSKPC 1335
C CP +CQ D SP S C G G QP G CP + Q C
Sbjct: 3536 HPCGQPCPRSCQ--DLSPGSVCQP--GSVG--------CQPTCG----CPLGQLSQDGLC 3579
Query: 1336 PVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCV----VSDGSADDFSKVVDEEFCADI 1391
R QY + + G+R + + V G D+ + V C ++
Sbjct: 3580 VPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEV 3639
Query: 1392 ELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQ 1451
CP W W C ++C GE L + +RP
Sbjct: 3640 -----------------PDCPDPGVWSSWGPWEDCSVSCGGGEQL---RSRRCARPPCPG 3679
Query: 1452 ELENQHLCPEQMLETKSCYDGQCY 1475
C Q+ C G+ Y
Sbjct: 3680 PARQSRTCSTQVCREAGCPAGRLY 3703
Score = 113 bits (283), Expect = 1e-24
Identities = 289/1328 (21%), Positives = 445/1328 (33%), Gaps = 302/1328 (22%)
Query: 44 AGRAAAQGEAEAPTLYLWKT-GPWGRCMGDECGPGGIQTRAVWCAHV-------EGWTTL 95
AG Q + P +W + GPW C CG GG Q R+ CA + T
Sbjct: 3631 AGILQCQEVPDCPDPGVWSSWGPWEDC-SVSCG-GGEQLRSRRCARPPCPGPARQSRTCS 3688
Query: 96 HTNCKQAERPNNQ--------------------------QNCFKVCDWHKELYDWRLGPW 129
C++A P + + C + C + + RL
Sbjct: 3689 TQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACV 3748
Query: 130 NQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLI 189
+C V++ L + L G+ G + + + + C K +
Sbjct: 3749 QECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGK--------L 3800
Query: 190 PCQ-QDCIVSE-----FSAWSECSKTCGSGLQHRTRH---VVAPPQFGGSGCPNLTEFQV 240
C DC ++ +S W CS++CG GL RTR V+ P G GC +
Sbjct: 3801 SCSLDDCFEADGGFGPWSPWGPCSRSCG-GLGTRTRSRQCVLTMPTLSGQGCRGPRQDLE 3859
Query: 241 CQSSPCEAEELRYSLHV-------GPWSTCSMPHSRQVRQ-ARRRGKNKEREKDRSKGVK 292
C S C E V GPWS+ S P SR AR +++ R + +
Sbjct: 3860 CPSPDCPGAEGSTVEPVTGLPGGWGPWSSWS-PCSRSCTDPARPAWRSRTRLCLANCTMG 3918
Query: 293 DPEARELIKKKRNRNRQNRQE------------NKYWDIQIGY----------QTREVMC 330
DP ++R N + E N W + Q R +
Sbjct: 3919 DP------LQERPCNLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRLRA 3972
Query: 331 INKTGKAA----DLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTR 386
G ++ QE+ ++C + S WS WS C ++C G
Sbjct: 3973 YRPPGPGGHWCPNILTAYQERRFCNLRACPVPGGW--SRWSPWSWCDRSC-----GGGQS 4025
Query: 387 VRTRTIRQ-------FPIGSEKECPEFEEKEPC---LSQGDGVVPCATYGWR----TTEW 432
+R+R+ P E+ PC G VV CA R E
Sbjct: 4026 LRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRRCSDLQEG 4085
Query: 433 TECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLK 492
C+ D + + + GG + C A + + S H++ +
Sbjct: 4086 IVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQD----ACNNCS 4141
Query: 493 LCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGG 552
G + T Q C P PT C S WSAW PC++ +C G +G + R R T G
Sbjct: 4142 CQAGQLSCTAQPC--PPPTHCAWSHWSAWSPCSH-SC----GPRGQQSRFR----SSTSG 4190
Query: 553 SGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVD 612
S ++ PC +P+C C GT+ + + GE
Sbjct: 4191 SWAPECREEQSQSQPCPQPSC---------------PPLCLQGTRSRTLGDSWLQGE--- 4232
Query: 613 RQLCRDAIFPIPVAC-DAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGE 671
R + P V C D C + WS+WS C +C G G Q+R R+ A A
Sbjct: 4233 --CQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGG----GNQVRTRACRAAAPH 4286
Query: 672 EGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVG 731
C + C P + GPWG C SC G
Sbjct: 4287 HRSPPCLGPDTQTRQQPC---PGLLEACSWGPWGPC-----------------SRSCGPG 4326
Query: 732 MQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGD 791
+ +R C + + + P L +T PC ++C+ + +S WT C SC+
Sbjct: 4327 LASRSGSCPCL-MAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRC--SCR--- 4380
Query: 792 SSIRKQSRHRVIIQLPANGGRDCT-------------------DPLYEEKACEAPQACQS 832
++++ RH+ A G CT P +E AC +P A
Sbjct: 4381 VLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISNCSEDSCTPPFEFHACGSPCAGLC 4440
Query: 833 YRWKTHKWRRCQLVPWSVQQDSPGAQEGC----GPGRQA------------------RAI 870
+H+ + QD P Q GC G QA +
Sbjct: 4441 ATHLSHQ----------LCQDLPPCQPGCYCPKGLLEQAGGCIPPEECNCWHTSAAGAGM 4490
Query: 871 TCRKQDGGQAGIHECLQYAGPVPALTQACQ--IPCQDDCQLTSWSKFSSCNGDC---GAV 925
T D Q G EC G + +Q CQ +P L+ WS++S C G C A+
Sbjct: 4491 TLAPGDRLQLGCKECECRRGELHCTSQGCQGLLP------LSEWSEWSPC-GPCLPPSAL 4543
Query: 926 RTRKRTLVGKSKKKEKCKNS-HLYPLIETQY----CPCDKYNAQPVGNWSDCILPEGKVE 980
RT + + ++ S L PL+ ++ D +P W+ P
Sbjct: 4544 APASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCLDPATGRP---WTGA--PHLCTA 4598
Query: 981 VLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSE 1040
L ++ D C ++ + C +PC +L
Sbjct: 4599 PLSQQRLCPDPGACPDSCQWSLWGPW-------------------SPCQVPCSGGFRL-- 4637
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWV 1100
W CG G R W +E NGG PCP+ + Q V+ + C + C
Sbjct: 4638 --RWREAEALCGGG--CREPWAQES-CNGG-PCPECE--AQDTVF-TLDCANQCPHS--C 4686
Query: 1101 TEPWSICKVTFVNMRENC----GEGVQTRKVRCMQNTADG-PSEHVEDYLCDPEEMPLGS 1155
+ W + R C G+ VQ + + + G PS + L + + L
Sbjct: 4687 ADLWDRVQCLQGPCRPGCRCPPGQLVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDC 4746
Query: 1156 RVC-----KLPCP-EDC-VISEWGPWTQCVLPCNQSSF-RQRSADPIRQPADEGRSCPNA 1207
+ C L CP ++C V+ W W+ C PC + R R+ + P +
Sbjct: 4747 QNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCE--GGPGVAPCQAQDT 4804
Query: 1208 VEKEPCNL 1215
+++ CNL
Sbjct: 4805 EQRQECNL 4812
Score = 107 bits (266), Expect = 1e-22
Identities = 152/664 (22%), Positives = 225/664 (33%), Gaps = 169/664 (25%)
Query: 771 DCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQAC 830
DC++ P+S W+SC SC G + R++ +++ P GG C + ++C
Sbjct: 2500 DCVLAPWSVWSSCSRSCGLGLTFQRQE-----LLRPPLPGG-SCPRDRFRSQSCFVQACP 2553
Query: 831 QSYRWKTHK-WRRCQLVPWSVQQDSPGAQEGCGPGRQARAITC--------------RKQ 875
+ W + W C + CG G Q+R +C Q
Sbjct: 2554 VAGAWAMWEAWGPCSV--------------SCGGGHQSRQRSCVDPPPKNGGAPCPGASQ 2599
Query: 876 DGGQAGIHECLQYA----GPVPALTQACQI----PCQDDCQLTSWSKFSSCNGDCGAVRT 927
+ G+ C G V CQ PC C ++ SC+G C
Sbjct: 2600 ERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANR--SCSGHCVE--- 2654
Query: 928 RKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKV 987
R G +C PL E CPC VG L V LLG
Sbjct: 2655 GCRCPPGLLLHDTRC-----LPLSE---CPC------LVGEE----LKWPGVSFLLG--- 2693
Query: 988 QGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRC 1047
C Q C + G L+ C G CP C S WS+W+ C
Sbjct: 2694 -----NCSQ--------CVCEKGELL----CQPGG---------CPLPCGWSAWSSWAPC 2727
Query: 1048 SKSCGSGVKVRSKWLREKPYN-GGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSI 1106
+SCGSGV+ R + P GG PC + E+ CH+ C ++ PW+
Sbjct: 2728 DRSCGSGVRARFRSPSNPPAAWGGAPC-------EGDRQELQGCHTVCGTEVFGWTPWT- 2779
Query: 1107 CKVTFVNMRENC-----GEGVQTRKVRC-MQNTADGPSEHVEDYLCDPEEMPLGSRVCKL 1160
++ + ++C G G ++R C + P + ++ C P
Sbjct: 2780 ---SWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPCSPP----------- 2825
Query: 1161 PCPEDCVISEWGPWTQCVLPCNQS-SFRQRSADPIRQPADEGRSCPNA-VEKEPCNLNKN 1218
CP + W PW+ C PC+ R RS + P D +CP + CN
Sbjct: 2826 VCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSL-APGD--TTCPGPHSQTRDCNTQPC 2882
Query: 1219 CYHYDYNVTDWSTCQLSEK------------------------AVCGNGIKTRMLDCVRS 1254
N+ S Q ++ C G+ C+
Sbjct: 2883 TAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPR 2942
Query: 1255 DGKSVDLK---YCEALGLEKNWQMNTSCM--------VECPVNCQLSDWSPWSECSQTCG 1303
L Y + N +C+ CPV C S W+ WS CS +C
Sbjct: 2943 SQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCN 3002
Query: 1304 LTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC--YRWQYGQWSPCQVQEAQCGEG 1361
+ + R P G C +++ C ++PC ++G WSPC V CG G
Sbjct: 3003 VGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGGEWGPWSPCSV---PCGGG 3059
Query: 1362 TRTR 1365
R R
Sbjct: 3060 YRNR 3063
Score = 103 bits (257), Expect = 1e-21
Identities = 242/1081 (22%), Positives = 347/1081 (32%), Gaps = 299/1081 (27%)
Query: 171 DIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPP-QFGG 229
+I+ Y E + +AC +P S +S WS C ++CG G R+R +PP + GG
Sbjct: 3985 NILTAYQERRFCNLRACPVPGGW----SRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGG 4040
Query: 230 SGCP-NLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRS 288
+ C + ++C PCEA P +V R R D
Sbjct: 4041 APCAGERHQARLCNPMPCEA---------------GCPAGMEVVTCANR--CPRRCSDLQ 4083
Query: 289 KGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGY------QTREVMCINKTGKAADLSF 342
+G+ + + + +K R + E + IG+ Q ++ A +
Sbjct: 4084 EGIVCQD--DQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCS 4141
Query: 343 CQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSE-- 400
CQ +L T Q C C S WS WSPCS +C P G + R R+ E
Sbjct: 4142 CQAGQLSCTAQPCPPPTHCAWSHWSAWSPCSHSC----GPRGQQSRFRSSTSGSWAPECR 4197
Query: 401 ------KECPEFEEKEPCLS------------QGDGVVPCATYGWRTTEWTECRVDPLLS 442
+ CP+ CL QG+ T E TEC V P
Sbjct: 4198 EEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAV-PEAW 4256
Query: 443 QQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTT 502
+ CGGG Q R C A + H++ C GP T
Sbjct: 4257 TLWSSWSDCPVSCGGGNQVRTRACRAAAPH-------HRSPP---------CLGPDTQTR 4300
Query: 503 QLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHL 562
Q PCP E W WGPC+ +C G + +G+CP L
Sbjct: 4301 QQ---PCPGLLEACSWGPWGPCS-RSCG-------------------PGLASRSGSCPCL 4337
Query: 563 LEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFP 622
+ +P C NS +D Q C
Sbjct: 4338 MAK---ADPTC-------------------------------NSTFLHLDTQGC------ 4357
Query: 623 IPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSA 682
PCP++CV S+WS+W+ CS C + ++ R + A G G C
Sbjct: 4358 ----YSGPCPEECVWSSWSSWTRCS--C--RVLVQQRYRHQG-PASRGARAGAPCTRLDG 4408
Query: 683 LQE---VRSCNEHPCT---VYHWQTGPW-GQCIEDTSVSSFNTTTTWNGEASCSVGMQTR 735
+ +C+E CT +H P G C S C G+ +
Sbjct: 4409 HFRPCLISNCSEDSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQ 4468
Query: 736 KVICV-----------RVNVG---------QVGPKKCPESLRPE---TVRPC--LLPCKK 770
C+ G Q+G K+C E R E T + C LLP
Sbjct: 4469 AGGCIPPEECNCWHTSAAGAGMTLAPGDRLQLGCKEC-ECRRGELHCTSQGCQGLLP--- 4524
Query: 771 DCIVTPYSDWTSC-----PSSCKEGDSS---------------------IRKQSRHRVII 804
++ +S+W+ C PS+ + +Q RHR+ +
Sbjct: 4525 ---LSEWSEWSPCGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCL 4581
Query: 805 QLPANG------GRDCTDPLYEEKACEAPQAC-QSYRWKT-HKWRRCQLVPWS--VQQDS 854
PA G CT PL +++ C P AC S +W W CQ VP S +
Sbjct: 4582 D-PATGRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQ-VPCSGGFRLRW 4639
Query: 855 PGAQEGCGPGRQARAITCRK---QDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTS 911
A+ CG G CR+ Q+ G C + T C C C
Sbjct: 4640 REAEALCGGG-------CREPWAQESCNGG--PCPECEAQDTVFTLDCANQCPHSC-ADL 4689
Query: 912 WSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSD 971
W + G C R R G+ + +C + C C +A +W
Sbjct: 4690 WDRVQCLQGPC---RPGCRCPPGQLVQDGRC--------VPISSCRCGLPSAN--ASW-- 4734
Query: 972 CILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIP 1031
E+ VQ D + C C + E+ + P
Sbjct: 4735 --------ELAPAQAVQLDCQNC---------TC------------------VNESLVCP 4759
Query: 1032 CPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVP-- 1089
L WS WS CS CG G R + P G PC D Q Q + P
Sbjct: 4760 HQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGP--GVAPCQAQD-TEQRQECNLQPCP 4816
Query: 1090 ----------CHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSE 1139
C + C W +P +IC C G C+ TA ++
Sbjct: 4817 ECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTACPCTQ 4876
Query: 1140 H 1140
H
Sbjct: 4877 H 4877
Score = 102 bits (254), Expect = 3e-21
Identities = 272/1263 (21%), Positives = 376/1263 (29%), Gaps = 345/1263 (27%)
Query: 341 SFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSE 400
S C EK + Q C S WS W+PC ++C +G R R R S
Sbjct: 2696 SQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSC-----GSGVRARFR--------SP 2742
Query: 401 KECPEFEEKEPCLSQGDGVVPCAT------YGWRT-TEWTECRVDPLLSQQDKRRGNQTA 453
P PC + C T +GW T W+ C SQ G
Sbjct: 2743 SNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSC------SQSCLAPGG--- 2793
Query: 454 LCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTEC 513
G G ++R C ++ +T + C+ P+ CP
Sbjct: 2794 --GPGWRSRSRLCPSPGDSSCPGDATQEEP----------CSPPV----------CPVPS 2831
Query: 514 EVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGS---------------GVTGN 558
W+ W C+ C+ G + R R ++ G + T
Sbjct: 2832 IWGLWAPWSTCS-APCDG-----GIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQ 2885
Query: 559 CPHLL----------EAIPCEEPACYDWKAVR-LGNCEPDNGKECGPGTQVQEVVC---- 603
CP + E PC + G C P G C PG + C
Sbjct: 2886 CPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAP--GCTCPPGLFLHNASCLPRS 2943
Query: 604 ---------INSDGEEVDRQLCRD-AIFPIPVACDAP-CPKDCVLSTWSTWSSCSHTCSG 652
+ + G C + +AC + CP C S W+ WS CS +C+
Sbjct: 2944 QCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCN- 3002
Query: 653 KTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTS 712
G + R R+ A GG C + E C+ PC + GPW C
Sbjct: 3003 ---VGIRRRFRAGTAPPAAFGGAECQGPT--MEAEFCSLRPCPGPGGEWGPWSPC----- 3052
Query: 713 VSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLP----C 768
C G + R G + ++PC P C
Sbjct: 3053 ------------SVPCGGGYRNR----------TRGSSRSLMEFSTCGLQPCAGPVPGMC 3090
Query: 769 KKDCIVTPYSDWTSC---PSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACE 825
+D W C P+SC E + P + C C
Sbjct: 3091 PRD------KQWLDCAQGPASCAE--------------LSAPRGTNQTC------HPGCH 3124
Query: 826 APQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHEC 885
P C VP QD P A EG G + C
Sbjct: 3125 CPSGMLLLN------NVC--VP---TQDCPCAHEG------------HLYPPGSTVVRPC 3161
Query: 886 LQYAGPVPALTQACQIPC-QDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKN 944
+ + PC + + + W+ +S C+ CG R + +S
Sbjct: 3162 ENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTV 3221
Query: 945 SHL-YPLIETQYCP-------------CDKYNA-QPVGNWSDCILPEGKVEVLLGMKVQG 989
+ L P T C CD+ P G WS C
Sbjct: 3222 APLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHC----------------- 3264
Query: 990 DIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEAC-IIPCP-SDCKLSEWSNWSRC 1047
+ CG G R + AC DQ C E C +PCP ++C E + +S C
Sbjct: 3265 -SRSCGGGLRSRTRAC-DQPPPQGLGDYCEGPRAQGEVCQALPCPVTNCTAIEGAEYSPC 3322
Query: 1048 SKSCGSGVK--VRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLW------ 1099
C V W R +P G CP ++ V P H C L
Sbjct: 3323 GPPCPRSCDDLVHCVW-RCQP---GCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHP 3378
Query: 1100 ---VTEPWSICKVTFVNMRENC---------GEGVQTRKVRCMQ----------NTADGP 1137
+ P T + R NC G + C Q P
Sbjct: 3379 GARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACP 3438
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPE------DCVISEWGPWTQCVLPCNQSSFRQRSA 1191
+ C E G++ + CP D WGPW+ C + C S R R+
Sbjct: 3439 TPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDM-CLGQSHRSRAC 3497
Query: 1192 DPIRQPADE-GRSCP-NAVEKEPCNLNK---------NCYHYDYNVTDWSTCQLSEKAVC 1240
R P E GR CP N + PC N H S LS +VC
Sbjct: 3498 S--RPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVC 3555
Query: 1241 GNGIKTRMLDC------VRSDGKSVDLKYCE------ALGLEKN-----------WQM-- 1275
G C + DG V +C A+G+ +N W+
Sbjct: 3556 QPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLE 3615
Query: 1276 ----------NTSCMV---------ECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQ 1316
N +C+ +CP S W PW +CS +CG G+ +R R +
Sbjct: 3616 PGEVVTGPCDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCG-GGEQLRSRRCAR 3674
Query: 1317 PFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSA 1376
P PCP QS+ C + C + G + +E Q GEG SC
Sbjct: 3675 P------PCPGPARQSRTCSTQVCR--EAGCPAGRLYRECQPGEGC---PFSCAHVTQQV 3723
Query: 1377 DDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDL 1436
FS+ EE C E +C Q CP C L W L G+ L
Sbjct: 3724 GCFSEGC-EEGCHCPEGTFQHRL------ACVQECP--CVLTAWLLQELGATIGDPGQPL 3774
Query: 1437 GFG 1439
G G
Sbjct: 3775 GPG 3777
Score = 97.4 bits (241), Expect = 1e-19
Identities = 267/1207 (22%), Positives = 381/1207 (31%), Gaps = 289/1207 (23%)
Query: 360 ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGV 419
+C ++ WS WS CS++C G + + + + P+ CP ++ SQ V
Sbjct: 2500 DCVLAPWSVWSSCSRSC-----GLGLTFQRQELLRPPLPG-GSCP----RDRFRSQSCFV 2549
Query: 420 VPCATYG-WRTTE-WTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQL 477
C G W E W C V CGGG Q+R+ CV
Sbjct: 2550 QACPVAGAWAMWEAWGPCSVS----------------CGGGHQSRQRSCVDPPPKNGGAP 2593
Query: 478 STHKNKEASKPMDLKLCT-------GPIPNTTQLCH----IPCPTEC--EVSPWSAWGPC 524
++E + P L+ C+ G + + LC PCP C + S G C
Sbjct: 2594 CPGASQERA-PCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHC 2652
Query: 525 TYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVR--LG 582
E C + G L R C L E PC W V LG
Sbjct: 2653 V-EGC---RCPPGLLLHDTR--------------CLPLSEC-PCLVGEELKWPGVSFLLG 2693
Query: 583 NCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWST 642
NC C+ GE LC+ CP C S WS+
Sbjct: 2694 NCSQ----------------CVCEKGE----LLCQ----------PGGCPLPCGWSAWSS 2723
Query: 643 WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-VYHWQT 701
W+ C +C G + R RS GG C QE++ C+ T V+ W
Sbjct: 2724 WAPCDRSCG----SGVRARFRSPSNPPAAWGGAPCEGDR--QELQGCHTVCGTEVFGWT- 2776
Query: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETV 761
PW TS SS + + G G ++R +C G CP E
Sbjct: 2777 -PW------TSWSSCSQSCLAPGGGP---GWRSRSRLC-----PSPGDSSCPGDATQE-- 2819
Query: 762 RPCLLP-CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYE 820
PC P C I ++ W++C + C G Q+R R L A G C P +
Sbjct: 2820 EPCSPPVCPVPSIWGLWAPWSTCSAPCDGG-----IQTRGRSCSSL-APGDTTCPGPHSQ 2873
Query: 821 EKACEAPQACQSYRWKTHKWRRCQL-------VPWSVQQDSPGAQ--------EGCGPGR 865
+ C Q C + + +R + P PG + C PG
Sbjct: 2874 TRDCNT-QPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGL 2932
Query: 866 QARAITCRKQDGGQAGIHECLQYAGPVPAL-----------TQACQIP-CQDDCQLTSWS 913
+C + +H L +G + L AC C C + W+
Sbjct: 2933 FLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWT 2992
Query: 914 KFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYC---PCDKYNAQPVGNWS 970
+S C+ C V R+R G + P +E ++C PC + G WS
Sbjct: 2993 LWSLCSCSCN-VGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGGE-WGPWS 3050
Query: 971 DCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACII 1030
C +P CG GYR + + L+E S C + C
Sbjct: 3051 PCSVP------------------CGGGYRNRTRG---SSRSLMEFSTCGL-----QPCAG 3084
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPK--LDHVNQAQVYEVV 1088
P P C + W C++ S ++ + + + G CP L N +
Sbjct: 3085 PVPGMCPRDK--QWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDC 3142
Query: 1089 PCHSDCNQY---LWVTEPWSICKVTFVNMRENC-------GEGVQTRKVRCMQNTAD-GP 1137
PC + + Y V P C + NC GE + Q +A GP
Sbjct: 3143 PCAHEGHLYPPGSTVVRPCENCSCV-SGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGP 3201
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCP--------------EDCVI---------SEWGPW 1174
+ C + S V LP P E C++ WGPW
Sbjct: 3202 ARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPW 3261
Query: 1175 TQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQL 1234
+ C C + A P G C + P + C VT+ + +
Sbjct: 3262 SHCSRSCGGGLRSRTRACDQPPPQGLGDYC-----EGPRAQGEVCQALPCPVTNCTAIEG 3316
Query: 1235 SEKAVCGNGIKTRMLDCVR------------------SDGK-SVDLKYCEALGLEKNWQM 1275
+E + CG D V S+G V +C L L +
Sbjct: 3317 AEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRH 3376
Query: 1276 NTSCMVECPVNCQ------------------LSDWSPWSE---CSQTC-GLTGKMIRRRT 1313
+ + P C W PWSE CSQ C G T R
Sbjct: 3377 HPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACA 3436
Query: 1314 VTQPFQGDGRPCPSLMDQS------------KPCPVKPCYRWQYGQWSPCQVQEAQCGEG 1361
P G G PC ++ CPV + +G WSPC + G+
Sbjct: 3437 CPTPQHG-GAPCTGEAGEAGAQHQREACPSYATCPVDGAW-GPWGPWSPC---DMCLGQS 3491
Query: 1362 TRTRNIS-CVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDW 1420
R+R S +G C + C QPCP C +D
Sbjct: 3492 HRSRACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSC--QDL 3549
Query: 1421 SSWSLCQ 1427
S S+CQ
Sbjct: 3550 SPGSVCQ 3556
Score = 83.6 bits (205), Expect = 1e-15
Identities = 134/556 (24%), Positives = 180/556 (32%), Gaps = 106/556 (19%)
Query: 1022 GYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQ 1081
G E+ C+ DC L+ WS WS CS+SCG G+ + + L P GG CP+ +Q
Sbjct: 2492 GSDEDGCV-----DCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGG-SCPRDRFRSQ 2545
Query: 1082 AQVYEVVPCHSDCNQYLW-VTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH 1140
+ + P W + E W C V +CG G Q+R+ C+
Sbjct: 2546 SCFVQACPVAG-----AWAMWEAWGPCSV-------SCGGGHQSRQRSCVDPPPKNGGAP 2593
Query: 1141 VEDYLCDPEEMPLGSRVCKLPCPEDCVISE-WGPWTQC----VLPCNQSSFRQRSADPIR 1195
E P G + C DC + + C V PC S DP
Sbjct: 2594 CPG--ASQERAPCGLQPCS--GGTDCELGRVYVSADLCQKGLVPPCPPSCL-----DP-- 2642
Query: 1196 QPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSD 1255
RSC E C +D S C + G +K
Sbjct: 2643 ---KANRSCSGHC-VEGCRCPPGLLLHDTRCLPLSEC----PCLVGEELKW--------P 2686
Query: 1256 GKSVDLKYCEALGLEKNWQMNTSCMV-ECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTV 1314
G S L C EK C CP+ C S WS W+ C ++CG + R
Sbjct: 2687 GVSFLLGNCSQCVCEKG---ELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPS 2743
Query: 1315 TQPFQGDGRPCPSLMDQSKPCPV---KPCYRW-QYGQWSPCQVQ--EAQCGEGTRTRNIS 1368
P G PC + + C + W + WS C G G R+R+
Sbjct: 2744 NPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRL 2803
Query: 1369 CVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP-CPGDCYLKDWSSWSLCQ 1427
C S+ C + EE CS P CP W+ WS C
Sbjct: 2804 CPSPGDSS-----------CPG---------DATQEEPCSPPVCPVPSIWGLWAPWSTCS 2843
Query: 1428 LTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSC----YDGQCYEYKWMASA 1483
C GGIQ R R CP +T+ C QC E SA
Sbjct: 2844 APC-------DGGIQTRGRS-CSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSA 2895
Query: 1484 WKGSSRTVWCQR-----SDGINVTGGCLVMSQPDADRSCNPPCSQPHSYCSETKTCHCE- 1537
+ C R GI TG C +C P ++ C C C+
Sbjct: 2896 EQCHQEGGPCPRLCLTQGPGIECTGFCA------PGCTCPPGLFLHNASCLPRSQCPCQL 2949
Query: 1538 EGYTEVMSSNSTLEQC 1553
G + + L+ C
Sbjct: 2950 HGQLYASGAMARLDSC 2965
Score = 65.9 bits (159), Expect = 3e-10
Identities = 80/336 (23%), Positives = 113/336 (33%), Gaps = 70/336 (20%)
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWV 1100
WS W CS++CG + RS+ + CP +H Q+Q C D W
Sbjct: 1700 WSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEH--QSQACFTAACPVDGEWSTW- 1756
Query: 1101 TEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKL 1160
PWS+C E C G TR+ +C G + C L S
Sbjct: 1757 -SPWSVCS-------EPC-RGTMTRQRQCHSPQNGGRT-------CAALPGGLHSTRQTK 1800
Query: 1161 PCPEDCVISE-------WGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAV---EK 1210
PCP+D + + P C L C+ S Q + P G CP +
Sbjct: 1801 PCPQDGCPNATCSGELMFQPCAPCPLTCDDIS-GQVTCPPDWPCGSPGCWCPEGQVLGSE 1859
Query: 1211 EPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLE 1270
C + C W G IK C+ DG+
Sbjct: 1860 GWCVWPRQCPCLVDGARYWP----------GQRIKADCQLCICQDGR------------P 1897
Query: 1271 KNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPF-QGDGRPCPSLM 1329
+ ++N +C V+C S WSPW++C CG R+ P G GR C +
Sbjct: 1898 RRCRLNP----DCAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIH 1953
Query: 1330 DQSKPCPVKPC-------------YRWQYGQWSPCQ 1352
+++ C +PC RW G CQ
Sbjct: 1954 RKARRCQTEPCEGCEHQGQVHRVGERWHGGPCRVCQ 1989
Score = 61.6 bits (148), Expect = 6e-09
Identities = 90/344 (26%), Positives = 126/344 (36%), Gaps = 78/344 (22%)
Query: 1265 EALGLEKNWQMNTSCM----VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG 1320
E L E+ + C + V+C L+ WS WS CS++CGL R+ + P G
Sbjct: 2475 ECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPG 2534
Query: 1321 DGRPCPSLMDQS---KPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCV---VSDG 1374
P QS + CPV + + W PC V CG G ++R SCV +G
Sbjct: 2535 GSCPRDRFRSQSCFVQACPVAGAWA-MWEAWGPCSV---SCGGGHQSRQRSCVDPPPKNG 2590
Query: 1375 SADDFSKVVDEEFC--------ADIELIIDGNKNMVLEESCSQ----PCPGDCYLKDWSS 1422
A + C D EL + V + C + PCP C D +
Sbjct: 2591 GAPCPGASQERAPCGLQPCSGGTDCEL----GRVYVSADLCQKGLVPPCPPSCL--DPKA 2644
Query: 1423 WSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWM-A 1481
C CV G G + +R + + E CP C G+ E KW
Sbjct: 2645 NRSCSGHCVEGCRCPPGLLLHDTRCLPLSE------CP--------CLVGE--ELKWPGV 2688
Query: 1482 SAWKGSSRTVWCQRSDGINVTGGCLV-------MSQPDADRSC------------NPPCS 1522
S G+ C++ + + GGC + S DRSC NPP +
Sbjct: 2689 SFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAA 2748
Query: 1523 QPHSYC----SETKTCHCEEGYTEVM-----SSNSTLEQCTLIP 1557
+ C E + CH G TEV +S S+ Q L P
Sbjct: 2749 WGGAPCEGDRQELQGCHTVCG-TEVFGWTPWTSWSSCSQSCLAP 2791
Score = 58.9 bits (141), Expect = 4e-08
Identities = 162/755 (21%), Positives = 233/755 (30%), Gaps = 211/755 (27%)
Query: 903 CQD--------DCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQ 954
CQD DC L WS +SSC+ CG T +R L P +
Sbjct: 2489 CQDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQR-------------QELLRPPLPGG 2535
Query: 955 YCPCDKYNAQPVGNWSDCILPEGKVEVLLGM-KVQGDIK-ECGQGYRYQAMACYDQ---- 1008
CP D++ +Q C + V M + G CG G++ + +C D
Sbjct: 2536 SCPRDRFRSQ------SCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKN 2589
Query: 1009 -----NGRLVETSRCN-----------------SHGYIEEACIIPCPSDCKLSEWSNWSR 1046
G E + C S ++ + PCP C L +N S
Sbjct: 2590 GGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSC-LDPKANRS- 2647
Query: 1047 CSKSCGSGVKVRSKWLREKPYNGGRPCPK--LDHVNQAQVYEVVPCHSDCNQYLWVTEPW 1104
CS C G + CP L H + PC V E
Sbjct: 2648 CSGHCVEGCR----------------CPPGLLLHDTRCLPLSECPC--------LVGEEL 2683
Query: 1105 SICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPE 1164
V+F + NC + V C + + LC P CP
Sbjct: 2684 KWPGVSF--LLGNCSQCV------CEKG----------ELLCQPG-----------GCPL 2714
Query: 1165 DCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDY 1224
C S W W C C S R R P PA G + +E + C +
Sbjct: 2715 PCGWSAWSSWAPCDRSCG-SGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVF 2773
Query: 1225 N---VTDWSTCQLSEKAVCGN-GIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
T WS+C S A G G ++R C S C ++ C
Sbjct: 2774 GWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSS-----CPGDATQEEPCSPPVC- 2827
Query: 1281 VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
PV W+PWS CS C G R R+ + GD CP Q++ C +PC
Sbjct: 2828 ---PVPSIWGLWAPWSTCSAPCD-GGIQTRGRSCSSLAPGD-TTCPGPHSQTRDCNTQPC 2882
Query: 1341 -----YRWQYGQWSPCQVQEAQC-------GEGTRTRNI---SCVVSDGSADDFSKVVDE 1385
+ C + C G G C G + +
Sbjct: 2883 TAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPR 2942
Query: 1386 EFC-ADIELIIDGNKNMVLEESC-------------SQPCPGDCYLKDWSSWSLCQLTCV 1431
C + + + M +SC S+ CP C W+ WSLC +C
Sbjct: 2943 SQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCN 3002
Query: 1432 NG----------EDLGFGGIQVRSRPVIIQELENQHLCPEQMLE-------TKSCYDGQC 1474
G FGG + + P + E + CP E + C G
Sbjct: 3003 VGIRRRFRAGTAPPAAFGGAECQG-PTMEAEFCSLRPCPGPGGEWGPWSPCSVPCGGG-- 3059
Query: 1475 YEYKWMASAWKGSSRTVWCQRSDGINVTGG---------------------CLVMSQP-D 1512
+ +GSSR++ + G+ G C +S P
Sbjct: 3060 -----YRNRTRGSSRSLMEFSTCGLQPCAGPVPGMCPRDKQWLDCAQGPASCAELSAPRG 3114
Query: 1513 ADRSCNPPCSQP------HSYCSETKTCHC-EEGY 1540
+++C+P C P ++ C T+ C C EG+
Sbjct: 3115 TNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGH 3149
Score = 50.4 bits (119), Expect = 1e-05
Identities = 80/339 (23%), Positives = 104/339 (30%), Gaps = 77/339 (22%)
Query: 567 PCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVA 626
PC C W R C P + +V N G E Q C
Sbjct: 1705 PCSR-TCGPWGQGRSRRCSP-----------LGLLVLQNCPGPEHQSQAC---------- 1742
Query: 627 CDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRA-----RSILAYAGEEGGIR----- 676
A CP D STWS WS CS C G T +Q + R+ A G R
Sbjct: 1743 FTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPC 1802
Query: 677 ----CPNSSALQEVRSCNEHPCTVY------------HWQTGPWGQCIEDTSVSSFNTTT 720
CPN++ E+ PC + W G G + V
Sbjct: 1803 PQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWC 1862
Query: 721 TWNGEASCSVG------MQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIV 774
W + C V Q K C P++C L P+ C DC
Sbjct: 1863 VWPRQCPCLVDGARYWPGQRIKADCQLCICQDGRPRRC--RLNPD--------CAVDCGW 1912
Query: 775 TPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC--EAPQACQ- 831
+ +S W C C G SI+ R + P+ GR C + + C E + C+
Sbjct: 1913 SSWSPWAKCLGPC--GSQSIQWSFRSSNNPR-PSGRGRQCRGIHRKARRCQTEPCEGCEH 1969
Query: 832 -------SYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP 863
RW R CQ + SP G P
Sbjct: 1970 QGQVHRVGERWHGGPCRVCQCLHNLTAHCSPYCPLGSCP 2008
Score = 48.1 bits (113), Expect = 7e-05
Identities = 95/388 (24%), Positives = 127/388 (32%), Gaps = 103/388 (26%)
Query: 861 CGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQAC-QIPCQDDCQLTSWSKFSSCN 919
CGP Q R+ C G + C GP +QAC C D + ++WS +S C+
Sbjct: 1710 CGPWGQGRSRRCSPL--GLLVLQNC---PGPEHQ-SQACFTAACPVDGEWSTWSPWSVCS 1763
Query: 920 GDCGAVRTRKRTLVGKSKKKEKCKN--SHLYPLIETQYCP-------------------- 957
C TR+R C L+ +T+ CP
Sbjct: 1764 EPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDGCPNATCSGELMFQPCAP 1823
Query: 958 ----CDKYNAQ-------PVGNWSDCILPEGKVEVLLGMKVQGDIKEC---------GQG 997
CD + Q P G+ C PEG+V G V C GQ
Sbjct: 1824 CPLTCDDISGQVTCPPDWPCGS-PGCWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQR 1882
Query: 998 YRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGV-- 1055
+ C Q+GR RC + C DC S WS W++C CGS
Sbjct: 1883 IKADCQLCICQDGR---PRRCRLNP--------DCAVDCGWSSWSPWAKCLGPCGSQSIQ 1931
Query: 1056 -KVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCH--SDCNQYLWVTEPWSICKVTFV 1112
RS +P GR C + +A+ + PC Q V E W
Sbjct: 1932 WSFRSS-NNPRPSGRGRQCRGIH--RKARRCQTEPCEGCEHQGQVHRVGERW-------- 1980
Query: 1113 NMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISE-- 1170
G R +C+ N + H Y PLGS CP+ V+ E
Sbjct: 1981 -------HGGPCRVCQCLHNL----TAHCSPY------CPLGS------CPQGWVLVEGT 2017
Query: 1171 WGPWTQCVLPCNQSSFRQRSADPIRQPA 1198
C LP ++ Q A P PA
Sbjct: 2018 GESCCHCALP-GENQTVQPMATPAAAPA 2044
Score = 45.4 bits (106), Expect = 4e-04
Identities = 18/40 (45%), Positives = 28/40 (70%), Gaps = 1/40 (2%)
Query: 194 DCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP 233
DC+++ +S WS CS++CG GL + + ++ PP GGS CP
Sbjct: 2500 DCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGS-CP 2538
Score = 44.3 bits (103), Expect = 0.001
Identities = 47/176 (26%), Positives = 61/176 (34%), Gaps = 30/176 (17%)
Query: 1283 CPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG-----------DGRPCPSL--- 1328
CP +CQ S W PWS C C G +R R G +G PCP
Sbjct: 4612 CPDSCQWSLWGPWSPCQVPCS-GGFRLRWREAEALCGGGCREPWAQESCNGGPCPECEAQ 4670
Query: 1329 -----MDQSKPCPVKPCYRWQYGQW--SPCQVQEAQCGEGTRTRNISCV-VSDGSADDFS 1380
+D + CP W Q PC+ +C G ++ CV +S S
Sbjct: 4671 DTVFTLDCANQCPHSCADLWDRVQCLQGPCR-PGCRCPPGQLVQDGRCVPISSCRCGLPS 4729
Query: 1381 KVVDEEFCADIELIIDGNKNMVLEESC---SQPCPGDCYLKDWSSWSLCQLTCVNG 1433
E + +D + ES Q CP L WS+WS C C G
Sbjct: 4730 ANASWELAPAQAVQLDCQNCTCVNESLVCPHQECP---VLGPWSAWSSCSAPCGGG 4782
Score = 43.5 bits (101), Expect = 0.002
Identities = 43/148 (29%), Positives = 67/148 (45%), Gaps = 30/148 (20%)
Query: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
L+D R P ++C ++ + L+ P G+ C Q +CE E
Sbjct: 2664 LHDTRCLPLSECPCLVGEELKWP--------GVSFLLGNCSQ---------CVCEKGE-- 2704
Query: 181 PLLEQ--ACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPP-QFGGSGCP-NLT 236
LL Q C +PC S +S+W+ C ++CGSG++ R R PP +GG+ C +
Sbjct: 2705 -LLCQPGGCPLPCGW----SAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQ 2759
Query: 237 EFQVCQSSPCEAEELRYSLHVGPWSTCS 264
E Q C + C E ++ WS+CS
Sbjct: 2760 ELQGCH-TVCGTEVFGWTPWTS-WSSCS 2785
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/79 (35%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC-YRWQYGQWSP 1350
WSPW CS+TCG G+ RR + CP QS+ C C ++ WSP
Sbjct: 1700 WSPWGPCSRTCGPWGQGRSRRCSPLGLL-VLQNCPGPEHQSQACFTAACPVDGEWSTWSP 1758
Query: 1351 CQVQEAQCGEGTRTRNISC 1369
V C GT TR C
Sbjct: 1759 WSVCSEPC-RGTMTRQRQC 1776
Score = 42.7 bits (99), Expect = 0.003
Identities = 67/283 (23%), Positives = 89/283 (31%), Gaps = 78/283 (27%)
Query: 4 QARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYLWKT 63
Q R+ S + G+ P Q P P P L L+ R W
Sbjct: 4180 QQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDS---------WLQ 4230
Query: 64 GPWGRCMGDECGPGGIQTRAVWCAHVEGWT----------------TLHTNCKQAERPNN 107
G RC C P G+ CA E WT + T +A P++
Sbjct: 4231 GECQRC---SCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHH 4287
Query: 108 -------------QQNC---FKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEE 151
QQ C + C W GPW C S+S L G
Sbjct: 4288 RSPPCLGPDTQTRQQPCPGLLEACSW---------GPWGPC----SRSCGPGLASRSG-- 4332
Query: 152 GIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLI-PCQQDCIVSEFSAWSECSKTC 210
C+ D L Q C PC ++C+ S +S+W+ CS C
Sbjct: 4333 -----SCPCLMAKADPTCNSTFLH------LDTQGCYSGPCPEECVWSSWSSWTRCS--C 4379
Query: 211 GSGLQHRTRHVVAPPQFG---GSGCPNLT-EFQVCQSSPCEAE 249
+Q R RH P G G+ C L F+ C S C +
Sbjct: 4380 RVLVQQRYRH-QGPASRGARAGAPCTRLDGHFRPCLISNCSED 4421
Score = 41.6 bits (96), Expect = 0.006
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 185 QACLIP-CQQDCIVSEFSAWSECSKTCGSGLQHRTRHVV-APPQFGGSGCPNLTEFQV-C 241
Q+C + C + + AW CS +CG G Q R R V PP+ GG+ CP ++ + C
Sbjct: 2545 QSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604
Query: 242 QSSPC 246
PC
Sbjct: 2605 GLQPC 2609
Score = 40.8 bits (94), Expect = 0.011
Identities = 56/249 (22%), Positives = 88/249 (35%), Gaps = 58/249 (23%)
Query: 491 LKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPT 550
L+ C GP + CP + E S WS W C+ E C +G R+R+ +
Sbjct: 1729 LQNCPGPEHQSQACFTAACPVDGEWSTWSPWSVCS-EPC------RGTMTRQRQCHSPQN 1781
Query: 551 GG---SGVTGNCPHLLEAIPCEEPAC----------YDWKAVRLGNCEPDNGK------- 590
GG + + G + PC + C + A C+ +G+
Sbjct: 1782 GGRTCAALPGGLHSTRQTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDW 1841
Query: 591 ECG-PGTQVQEVVCINSDG----------------------EEVDRQL--CRDAIFPIPV 625
CG PG E + S+G + D QL C+D P
Sbjct: 1842 PCGSPGCWCPEGQVLGSEGWCVWPRQCPCLVDGARYWPGQRIKADCQLCICQDG-RPRRC 1900
Query: 626 ACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQE 685
+ C DC S+WS W+ C C ++ + R+ + +G G +C ++
Sbjct: 1901 RLNPDCAVDCGWSSWSPWAKCLGPCGSQSIQW-SFRSSNNPRPSGR--GRQC--RGIHRK 1955
Query: 686 VRSCNEHPC 694
R C PC
Sbjct: 1956 ARRCQTEPC 1964
Score = 36.2 bits (82), Expect = 0.27
Identities = 27/88 (30%), Positives = 38/88 (43%), Gaps = 10/88 (11%)
Query: 191 CQQDCIVSEFSAWSECSKTCGS-GLQHRTRHVVAP-PQFGGSGCPNL-TEFQVCQSSPCE 247
C DC S +S W++C CGS +Q R P P G C + + + CQ+ PCE
Sbjct: 1906 CAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPCE 1965
Query: 248 AEELRYSL-------HVGPWSTCSMPHS 268
E + + H GP C H+
Sbjct: 1966 GCEHQGQVHRVGERWHGGPCRVCQCLHN 1993
Score = 35.0 bits (79), Expect = 0.60
Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 8/81 (9%)
Query: 190 PCQQDCIV-SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLT-EFQVCQSSPC- 246
P +Q C +S W CS+TCG Q R+R CP + Q C ++ C
Sbjct: 1689 PEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACP 1748
Query: 247 -EAEELRYSLHVGPWSTCSMP 266
+ E +S PWS CS P
Sbjct: 1749 VDGEWSTWS----PWSVCSEP 1765
Score = 32.0 bits (71), Expect = 5.1
Identities = 24/75 (32%), Positives = 29/75 (38%), Gaps = 19/75 (25%)
Query: 1407 CSQP--CPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQML 1464
C P CP C W WS CQ+ C GG ++R R E + LC
Sbjct: 4606 CPDPGACPDSCQWSLWGPWSPCQVPC-------SGGFRLRWR-------EAEALCGGGCR 4651
Query: 1465 E---TKSCYDGQCYE 1476
E +SC G C E
Sbjct: 4652 EPWAQESCNGGPCPE 4666
Score = 31.6 bits (70), Expect = 6.7
Identities = 31/110 (28%), Positives = 39/110 (35%), Gaps = 31/110 (28%)
Query: 185 QACLIP-CQQDCIVSEFSAWSECSKTC-GSGLQHRTRHVVAPPQFGG------------- 229
QAC C D S +S WS CS+ C G+ + R H PQ GG
Sbjct: 1740 QACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCH---SPQNGGRTCAALPGGLHST 1796
Query: 230 --------SGCPNLT-----EFQVCQSSPCEAEELRYSLHVGPWSTCSMP 266
GCPN T FQ C P +++ + P C P
Sbjct: 1797 RQTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQVTCPPDWPCGSP 1846
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 129 bits (325), Expect = 2e-29
Identities = 118/460 (25%), Positives = 183/460 (39%), Gaps = 110/460 (23%)
Query: 1033 PSDCKLSEWSNWSRCSKS-CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCH 1091
P C S WS WS CS S C G ++R + L+ + + PCP + PC
Sbjct: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQ-LDLSVPCP--------DTQDFQPCM 490
Query: 1092 ---------SDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADG-----P 1137
S C W+T WS C ++ CG G+++R+ Q DG P
Sbjct: 491 GPGCSDEDGSTCTMSEWIT--WSPCSIS-------CGMGMRSRERYVKQFPEDGSVCTLP 541
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
+E E + E C P C+++EWG W +C C ++R P
Sbjct: 542 TEETEKCTVNEE--------CS---PSSCLMTEWGEWDECSATCGMG-MKKRHRMIKMNP 589
Query: 1198 ADEGRSCPNAVEKEPCNLNKNCYHYDYNVT---DWSTCQLSEKAVCGNGIKTRMLDCVRS 1254
AD + E C + + C+ ++ +WS C ++ CG G++TR R
Sbjct: 590 ADGSMCKAETSQAEKCMMPE-CHTIPCLLSPWSEWSDCSVT----CGKGMRTRQ----RM 640
Query: 1255 DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTV 1314
+L C E Q+ + ECP++C+L++WS WSEC+++CG G +IR R +
Sbjct: 641 LKSLAELGDCN----EDLEQVEKCMLPECPIDCELTEWSQWSECNKSCG-KGHVIRTRMI 695
Query: 1315 TQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
Q G PCP + Q K C ++ C R +P +Q+ + E +R
Sbjct: 696 QMEPQFGGAPCPETV-QRKKCRIRKCLR------NP-SIQKLRWREARESR--------- 738
Query: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGE 1434
+ EES + PG C ++ W++WS C C
Sbjct: 739 -----------------------RSEQLKEESEGEQFPG-CRMRPWTAWSECTKLC---- 770
Query: 1435 DLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQC 1474
GGIQ R V + +Q + E ++C C
Sbjct: 771 ---GGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
Score = 112 bits (279), Expect = 4e-24
Identities = 116/461 (25%), Positives = 170/461 (36%), Gaps = 109/461 (23%)
Query: 1047 CSKSCG-----------------SGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVP 1089
C+K CG SGV S P RP LDH Q+ Y+
Sbjct: 336 CTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHP-QSPFYD--- 391
Query: 1090 CHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCD-- 1147
E SI +V V + +G Q V ++V+D + D
Sbjct: 392 -----------PEGGSITQVARVVIERIARKGEQCNIV----------PDNVDDIVADLA 430
Query: 1148 PEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA 1207
PEE PE C+ S W PW+ C R R ++ D CP+
Sbjct: 431 PEEKDEDDT------PETCIYSNWSPWSACSSSTCDKGKRMRQR-MLKAQLDLSVPCPDT 483
Query: 1208 VEKEPCNLNKNCYHYDYNVTD------WSTCQLSEKAVCGNGIKTR--MLDCVRSDGKSV 1259
+ +PC + C D + WS C +S CG G+++R + DG
Sbjct: 484 QDFQPC-MGPGCSDEDGSTCTMSEWITWSPCSIS----CGMGMRSRERYVKQFPEDGSVC 538
Query: 1260 DLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQ 1319
L E + +N C P +C +++W W ECS TCG+ K R P
Sbjct: 539 TLPTEET----EKCTVNEECS---PSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNP-- 589
Query: 1320 GDGRPCPSLMDQSKPCPVK-----PCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
DG C + Q++ C + PC + +WS C V CG+G RTR
Sbjct: 590 ADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVT---CGKGMRTR--------- 637
Query: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP-CPGDCYLKDWSSWSLCQLTCVNG 1433
+ + + D N+++ E C P CP DC L +WS WS C +C G
Sbjct: 638 ----------QRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKG 687
Query: 1434 EDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQC 1474
+R+R + ++ CPE ++ K C +C
Sbjct: 688 H-------VIRTRMIQMEPQFGGAPCPE-TVQRKKCRIRKC 720
Score = 102 bits (255), Expect = 2e-21
Identities = 102/499 (20%), Positives = 173/499 (34%), Gaps = 145/499 (29%)
Query: 744 VGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSS-CKEGDSSIRKQSRHRV 802
V + P++ E PET CI + +S W++C SS C +G ++ + ++
Sbjct: 426 VADLAPEEKDEDDTPET-----------CIYSNWSPWSACSSSTCDKGKRMRQRMLKAQL 474
Query: 803 IIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCG 862
+ +P +D + + E C W T W C + CG
Sbjct: 475 DLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWIT--WSPCSI--------------SCG 518
Query: 863 PGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQD-------------DCQL 909
G ++R +Y P C +P ++ C +
Sbjct: 519 MGMRSRE-----------------RYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561
Query: 910 TSWSKFSSCNGDCGAVRTRKRTLV-----------GKSKKKEKCKNSHLYPLIETQYCPC 958
T W ++ C+ CG ++ ++ ++ + EKC + E PC
Sbjct: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCM------MPECHTIPC 615
Query: 959 DKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRC 1018
P WSDC + CG+G R + L E C
Sbjct: 616 ---LLSPWSEWSDCSVT------------------CGKGMRTRQRMLKS----LAELGDC 650
Query: 1019 NSHGYIEEACIIP-CPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLD 1077
N E C++P CP DC+L+EWS WS C+KSCG G +R++ ++ +P GG PCP+
Sbjct: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPE-- 708
Query: 1078 HVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGP 1137
T C++ C +K+R +
Sbjct: 709 -----------------------TVQRKKCRI------RKCLRNPSIQKLRWREARESRR 739
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
SE +++ + E+ P C + W W++C C + R
Sbjct: 740 SEQLKEE-SEGEQFP------------GCRMRPWTAWSECTKLCGGGIQERYMTVKKRFK 786
Query: 1198 ADEGRSCPNAVEKEPCNLN 1216
+ + SC + E CN++
Sbjct: 787 SSQFTSCKDKKEIRACNVH 805
Score = 97.4 bits (241), Expect = 1e-19
Identities = 95/404 (23%), Positives = 151/404 (37%), Gaps = 97/404 (24%)
Query: 510 PTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCE 569
P C S WS W C+ C+ KG ++R+R + + ++ CP + PC
Sbjct: 440 PETCIYSNWSPWSACSSSTCD-----KGKRMRQRMLKAQ----LDLSVPCPDTQDFQPCM 490
Query: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDG------EEVDRQLCRD-AIFP 622
P C D ++G C + C S G E +Q D ++
Sbjct: 491 GPGCSD-----------EDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCT 539
Query: 623 IPVACDAPC-------PKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI 675
+P C P C+++ W W CS TC G ++ R + G
Sbjct: 540 LPTEETEKCTVNEECSPSSCLMTEWGEWDECSATC------GMGMKKRHRMIKMNPADGS 593
Query: 676 RCPNSSALQE---VRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGM 732
C ++ E + C+ PC + W W C +C GM
Sbjct: 594 MCKAETSQAEKCMMPECHTIPCLLSPW--SEWSDC-----------------SVTCGKGM 634
Query: 733 QTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLP-CKKDCIVTPYSDWTSCPSSCKEGD 791
+TR+ + ++ ++G C E L E V C+LP C DC +T +S W+ C SC +G
Sbjct: 635 RTRQRML--KSLAELG--DCNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKG- 687
Query: 792 SSIRKQSRHRVIIQLPANGGRDCTDPLYEEKA----CEAPQACQSYRWKTHKWRR----- 842
R R+I P GG C + + +K C + Q RW+ + R
Sbjct: 688 ----HVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQL 743
Query: 843 -----------CQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQ 875
C++ PW+ + + CG G Q R +T +K+
Sbjct: 744 KEESEGEQFPGCRMRPWTAWSE---CTKLCGGGIQERYMTVKKR 784
Score = 96.7 bits (239), Expect = 2e-19
Identities = 109/448 (24%), Positives = 175/448 (39%), Gaps = 117/448 (26%)
Query: 632 PKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNE 691
P+ C+ S WS WS+CS S +GK++R R + A + + CP++ Q
Sbjct: 440 PETCIYSNWSPWSACS---SSTCDKGKRMRQRMLKAQL--DLSVPCPDTQDFQ------- 487
Query: 692 HPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNG-EASCSVGMQTRKVICVRVNVGQVGPK 750
PC GP G ED S + + TW+ SC +GM++R+ K
Sbjct: 488 -PC------MGP-GCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYV----------K 529
Query: 751 KCPE-----SLRPETVRPCLL--PCK-KDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRV 802
+ PE +L E C + C C++T + +W C ++C G + RHR+
Sbjct: 530 QFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMG-----MKKRHRM 584
Query: 803 IIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCG 862
I PA+G C + + C P+ C + C L PWS D CG
Sbjct: 585 IKMNPADGSM-CKAETSQAEKCMMPE-CHTI--------PCLLSPWSEWSD---CSVTCG 631
Query: 863 PGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSWSKFSSCNGD 921
G + R ++ A + +C + V + C +P C DC+LT WS++S CN
Sbjct: 632 KGMRTR----QRMLKSLAELGDCNEDLEQV----EKCMLPECPIDCELTEWSQWSECNKS 683
Query: 922 CG---AVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGK 978
CG +RTR + P CP
Sbjct: 684 CGKGHVIRTRM---------------IQMEPQFGGAPCP--------------------- 707
Query: 979 VEVLLGMKVQGDIKECGQGYRYQAMACYD-QNGRLVETSRCNSHGYIEEACIIPCPSDCK 1037
E + K + I++C + Q + + + R E + S G C +
Sbjct: 708 -ETVQRKKCR--IRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGC--------R 756
Query: 1038 LSEWSNWSRCSKSCGSGVKVRSKWLREK 1065
+ W+ WS C+K CG G++ R ++++
Sbjct: 757 MRPWTAWSECTKLCGGGIQERYMTVKKR 784
Score = 92.0 bits (227), Expect = 4e-18
Identities = 85/348 (24%), Positives = 130/348 (37%), Gaps = 92/348 (26%)
Query: 353 QSCVITKECQVS-----EWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFE 407
+ C + +EC S EW EW CS TC G + R R I+ P E
Sbjct: 546 EKCTVNEECSPSSCLMTEWGEWDECSATCG-----MGMKKRHRMIKMNPADGSMCKAETS 600
Query: 408 EKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCV 467
+ E C+ +PC W +EW++C V CG G++TR+
Sbjct: 601 QAEKCMMPECHTIPCLLSPW--SEWSDCSVT----------------CGKGMRTRQ---- 638
Query: 468 QANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP-CPTECEVSPWSAWGPCTY 526
+L L+ +L C + + C +P CP +CE++ WS W C
Sbjct: 639 ----RMLKSLA-----------ELGDCNEDLEQVEK-CMLPECPIDCELTEWSQWSECN- 681
Query: 527 ENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEP 586
++C KG +R R I EP G CP ++ C C +++
Sbjct: 682 KSCG-----KGHVIRTRMIQMEPQFGGAP---CPETVQRKKCRIRKCLRNPSIQ--KLRW 731
Query: 587 DNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSC 646
+E Q++E S+GE+ FP C + W+ WS C
Sbjct: 732 REARESRRSEQLKE----ESEGEQ----------FP-----------GCRMRPWTAWSEC 766
Query: 647 SHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
+ C G G Q R ++ C + +E+R+CN HPC
Sbjct: 767 TKLCGG----GIQERYMTVKKRFKSSQFTSCKDK---KEIRACNVHPC 807
Score = 88.6 bits (218), Expect = 5e-17
Identities = 88/343 (25%), Positives = 133/343 (38%), Gaps = 71/343 (20%)
Query: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQG---- 416
C S WS WS CS + D G R+R R ++ + CP+ ++ +PC+ G
Sbjct: 443 CIYSNWSPWSACSSSTCDK----GKRMRQRMLKA-QLDLSVPCPDTQDFQPCMGPGCSDE 497
Query: 417 DGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQ 476
DG C W T W+ C + CG G+++RE Y Q
Sbjct: 498 DGST-CTMSEWIT--WSPCSIS----------------CGMGMRSRERYVKQF------- 531
Query: 477 LSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP---CPTECEVSPWSAWGPCTYENCNDQQ 533
P D +CT P T + C + P+ C ++ W W C+ C
Sbjct: 532 -----------PEDGSVCTLPTEETEK-CTVNEECSPSSCLMTEWGEWDECS-ATCG--- 575
Query: 534 GKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCE-PDNGKEC 592
G K R R I P GS +A C P C+ + E D C
Sbjct: 576 --MGMKKRHRMIKMNPADGSMCKAETS---QAEKCMMPECHTIPCLLSPWSEWSDCSVTC 630
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSG 652
G G + ++ + + S E D C + + + CP DC L+ WS WS C+ +C
Sbjct: 631 GKGMRTRQRM-LKSLAELGD---CNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCG- 685
Query: 653 KTTEGKQIRARSILAYAGEEGGIRCPNSSALQE--VRSCNEHP 693
+G IR R ++ + GG CP + ++ +R C +P
Sbjct: 686 ---KGHVIRTR-MIQMEPQFGGAPCPETVQRKKCRIRKCLRNP 724
Score = 81.3 bits (199), Expect = 7e-15
Identities = 94/411 (22%), Positives = 153/411 (37%), Gaps = 97/411 (23%)
Query: 128 PWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQAC 187
PW+ C C KG+ Q + Q D +P D + +P + C
Sbjct: 450 PWSACSSST---------CDKGKRMRQ--RMLKAQLDLSVPCPDTQ----DFQPCMGPGC 494
Query: 188 LIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTE-------FQV 240
C +SE+ WS CS +CG G++ R R+V P+ GS C TE +
Sbjct: 495 SDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPE-DGSVCTLPTEETEKCTVNEE 553
Query: 241 CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI 300
C S C E G W CS +++ R K + K + ++
Sbjct: 554 CSPSSCLMTEW------GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMM 607
Query: 301 KKKRNRNRQNRQENKYWDIQI----GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCV 356
+ +++ D + G +TR+ M A+L C ++ + + C+
Sbjct: 608 PECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRM----LKSLAELGDCNEDLEQV--EKCM 661
Query: 357 ITK---ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL 413
+ + +C+++EWS+WS C+K+C G +RTR I+ P CPE +++ C
Sbjct: 662 LPECPIDCELTEWSQWSECNKSC-----GKGHVIRTRMIQMEPQFGGAPCPETVQRKKCR 716
Query: 414 ------------------------------SQGDGVVPCATYGWRTTEWTECRVDPLLSQ 443
S+G+ C W T W+EC
Sbjct: 717 IRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPW--TAWSEC-------- 766
Query: 444 QDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLC 494
T LCGGGIQ R Y SQ ++ K+K+ + ++ C
Sbjct: 767 --------TKLCGGGIQER--YMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
Score = 69.3 bits (168), Expect = 3e-11
Identities = 52/213 (24%), Positives = 81/213 (38%), Gaps = 40/213 (18%)
Query: 1282 ECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPC------ 1335
+ P C S+WSPWS CS + GK +R+R + PCP D +PC
Sbjct: 438 DTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD-LSVPCPDTQD-FQPCMGPGCS 495
Query: 1336 --PVKPCYRWQYGQWSPCQVQEAQCGEGTRTRN--ISCVVSDGSADDFSKVVDEEFCADI 1391
C ++ WSPC + CG G R+R + DGS
Sbjct: 496 DEDGSTCTMSEWITWSPCSI---SCGMGMRSRERYVKQFPEDGSV--------------C 538
Query: 1392 ELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQ 1451
L + + + E CS P C + +W W C TC G++ R R + +
Sbjct: 539 TLPTEETEKCTVNEECS---PSSCLMTEWGEWDECSATCGM-------GMKKRHRMIKMN 588
Query: 1452 ELENQHLCPEQMLETKSCYDGQCYEYKWMASAW 1484
+ +C + + + C +C+ + S W
Sbjct: 589 PADGS-MCKAETSQAEKCMMPECHTIPCLLSPW 620
Score = 67.8 bits (164), Expect = 8e-11
Identities = 85/356 (23%), Positives = 138/356 (38%), Gaps = 52/356 (14%)
Query: 193 QDCIVSEFSAWSEC-SKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEE- 250
+ CI S +S WS C S TC G + R R + A CP+ +FQ C C E+
Sbjct: 441 ETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDL-SVPCPDTQDFQPCMGPGCSDEDG 499
Query: 251 --LRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNR 308
S + WS CS+ +R R K + + + + ++ + +
Sbjct: 500 STCTMSEWI-TWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSS 558
Query: 309 QNRQENKYWD-----IQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVI----TK 359
E WD +G + R M AD S C+ E + C++ T
Sbjct: 559 CLMTEWGEWDECSATCGMGMKKRHRMI---KMNPADGSMCKAE--TSQAEKCMMPECHTI 613
Query: 360 ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPE-FEEKEPCLSQGDG 418
C +S WSEWS CS TC G +RTR + +C E E+ E C+ +
Sbjct: 614 PCLLSPWSEWSDCSVTC-------GKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLP-EC 665
Query: 419 VVPCATYGWRTTEWTECR--------VDPLLSQQDKRRGNQTALCGGGIQTREVYCVQAN 470
+ C W ++W+EC + + Q + + G A C +Q ++ +
Sbjct: 666 PIDCELTEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGG--APCPETVQRKKCRIRKCL 721
Query: 471 EN-LLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCT 525
N + +L + +E+ + LK ++ P C + PW+AW CT
Sbjct: 722 RNPSIQKLRWREARESRRSEQLK-------EESEGEQFP---GCRMRPWTAWSECT 767
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 113 bits (283), Expect = 1e-24
Identities = 97/347 (27%), Positives = 135/347 (38%), Gaps = 54/347 (15%)
Query: 1039 SEWSNWSRCSKSCGSGVKVRSKWLREK-PYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQY 1097
S+WS W CS +CG G++ RS+ + P NGG+PC D + + + PC D +
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDL--EMRNCQNKPCPVDGSWS 4590
Query: 1098 LWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRV 1157
W W C +CG G QTR C + PS C+ + + +
Sbjct: 4591 EWSL--WEECT-------RSCGRGNQTRTRTC-----NNPSVQHGGRPCEGNAVEI--IM 4634
Query: 1158 CKL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA-VEKEPCNL 1215
C + PCP S W PW C C + + + PA G C A + + CN
Sbjct: 4635 CNIRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCN- 4693
Query: 1216 NKNCYHYDYNVT--DWSTCQLSEKAVCGNGIKTRMLDCV---------RSDGKSVDLKYC 1264
+NC + T WS C +S CG G + R C + +G V +C
Sbjct: 4694 ERNCPIHGKWATWASWSACSVS----CGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFC 4749
Query: 1265 EALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG-R 1323
+ CP + S WS W CS+TC G+M R RT P +G R
Sbjct: 4750 NS--------------DPCPTHGNWSPWSGWGTCSRTCN-GGQMRRYRTCDNPPPSNGGR 4794
Query: 1324 PCPSLMDQSKPCPVKPC-YRWQYGQWSPCQVQEAQCGEGTRTRNISC 1369
C Q + C C +G W A CG G +TR C
Sbjct: 4795 ACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLC 4841
Score = 112 bits (281), Expect = 2e-24
Identities = 95/321 (29%), Positives = 138/321 (42%), Gaps = 45/321 (14%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPKLDHVNQAQVYEVVP 1089
PCP D SEWS W C++SCG G + R++ +GGRPC + E++
Sbjct: 4582 PCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPC-------EGNAVEIIM 4634
Query: 1090 CH-SDCNQY-LW-VTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLC 1146
C+ C + W +PW C E+CG+G QTR C + P C
Sbjct: 4635 CNIRPCPVHGAWSAWQPWGTCS-------ESCGKGTQTRARLC-----NNPPPAFGGSYC 4682
Query: 1147 DPEEMPLGSRVC-KLPCPEDCVISEWGPWTQCVLPCNQSSFRQRS---ADPIRQPADEGR 1202
D E + +VC + CP + W W+ C + C + RQR+ +DP+ P GR
Sbjct: 4683 DGAETQM--QVCNERNCPIHGKWATWASWSACSVSCGGGA-RQRTRGCSDPV--PQYGGR 4737
Query: 1203 SCPNA-VEKEPCNLNKNCYHYDYNV-TDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD 1260
C + V+ + CN + H +++ + W TC C G R C + S
Sbjct: 4738 KCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTC----SRTCNGGQMRRYRTC-DNPPPSNG 4792
Query: 1261 LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQ- 1319
+ C G + Q + M CPV+ W WS+CS +CG G+ R+R P
Sbjct: 4793 GRACG--GPDSQIQRCNTDM--CPVDGSWGSWHSWSQCSASCG-GGEKTRKRLCDHPVPV 4847
Query: 1320 GDGRPCPSLMDQSKPCPVKPC 1340
GRPCP Q C V+ C
Sbjct: 4848 KGGRPCPGDTTQVTRCNVQAC 4868
Score = 99.4 bits (246), Expect = 3e-20
Identities = 101/355 (28%), Positives = 141/355 (39%), Gaps = 52/355 (14%)
Query: 1087 VVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT-ADGPSEHVEDYL 1145
+V H +Q+ W C VT CG+G+Q R C Q A+G
Sbjct: 4525 IVQVHGGFSQW----SAWRACSVT-------CGKGIQKRSRLCNQPLPANGGKP------ 4567
Query: 1146 CDPEEMPLGSRVCK-LPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADE--GR 1202
C ++ + R C+ PCP D SEW W +C C + + Q P+ + GR
Sbjct: 4568 CQGSDLEM--RNCQNKPCPVDGSWSEWSLWEECTRSCGRGN--QTRTRTCNNPSVQHGGR 4623
Query: 1203 SCP-NAVEKEPCNLNKNCYHYDYNVTD-WSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD 1260
C NAVE CN+ H ++ W TC S CG G +TR C + +
Sbjct: 4624 PCEGNAVEIIMCNIRPCPVHGAWSAWQPWGTCSES----CGKGTQTRARLC-NNPPPAFG 4678
Query: 1261 LKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPF-Q 1319
YC+ G E QM CP++ + + W+ WS CS +CG G R R + P Q
Sbjct: 4679 GSYCD--GAET--QMQVCNERNCPIHGKWATWASWSACSVSCG-GGARQRTRGCSDPVPQ 4733
Query: 1320 GDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDF 1379
GR C QS C PC +G WSP + G +RT N + + D+
Sbjct: 4734 YGGRKCEGSDVQSDFCNSDPCPT--HGNWSPW----SGWGTCSRTCNGGQMRRYRTCDNP 4787
Query: 1380 SKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGE 1434
C G + ++ + CP D W SWS C +C GE
Sbjct: 4788 PPSNGGRAC--------GGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGE 4834
Score = 87.0 bits (214), Expect = 1e-16
Identities = 83/317 (26%), Positives = 119/317 (37%), Gaps = 52/317 (16%)
Query: 1134 ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCV--ISEWGPWTQCVLPCNQSSFRQRSA 1191
AD E ++ C + +GS + ++P S+W W C + C + ++
Sbjct: 4497 ADAQKEDTSEFECVARNL-MGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRL 4555
Query: 1192 DPIRQPADEGRSCPNA-VEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLD 1250
PA+ G+ C + +E C NK C D + ++WS + ++ CG G +TR
Sbjct: 4556 CNQPLPANGGKPCQGSDLEMRNCQ-NKPC-PVDGSWSEWSLWEECTRS-CGRGNQTRTRT 4612
Query: 1251 C----VRSDGKSVDLKYCEALGLEKNWQMNTSCMVE-CPVNCQLSDWSPWSECSQTCGLT 1305
C V+ G+ CE +E C + CPV+ S W PW CS++CG
Sbjct: 4613 CNNPSVQHGGRP-----CEGNAVEI-----IMCNIRPCPVHGAWSAWQPWGTCSESCG-K 4661
Query: 1306 GKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPCY---RWQ-YGQWSPCQVQEAQCGE 1360
G R R P G C Q + C + C +W + WS C V CG
Sbjct: 4662 GTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVS---CGG 4718
Query: 1361 GTRTRNISC---VVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYL 1417
G R R C V G V +FC S PCP
Sbjct: 4719 GARQRTRGCSDPVPQYGGRKCEGSDVQSDFCN------------------SDPCPTHGNW 4760
Query: 1418 KDWSSWSLCQLTCVNGE 1434
WS W C TC G+
Sbjct: 4761 SPWSGWGTCSRTCNGGQ 4777
Score = 85.9 bits (211), Expect = 3e-16
Identities = 94/379 (24%), Positives = 133/379 (35%), Gaps = 76/379 (20%)
Query: 716 FNTTTTWNG-EASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCL-LPCKKDCI 773
F+ + W +C G+Q R +C + G K C S +R C PC D
Sbjct: 4532 FSQWSAWRACSVTCGKGIQKRSRLCNQPLPAN-GGKPCQGS--DLEMRNCQNKPCPVDGS 4588
Query: 774 VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSY 833
+ +S W C SC G+ + R ++ + +Q +GGR C E C
Sbjct: 4589 WSEWSLWEECTRSCGRGNQT-RTRTCNNPSVQ---HGGRPCEGNAVEIIMCNIRPCPVHG 4644
Query: 834 RWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVP 893
W W+ PW E CG G Q RA C G Y
Sbjct: 4645 AWSA--WQ-----PWGT------CSESCGKGTQTRARLCNNPPPAFGG-----SYCDGAE 4686
Query: 894 ALTQAC-QIPCQDDCQLTSWSKFSSCNGDCGA---VRTRKRTLVGKSKKKEKCKNSHLYP 949
Q C + C + +W+ +S+C+ CG RTR + KC+ S
Sbjct: 4687 TQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSD--- 4743
Query: 950 LIETQYC---PCDKY-NAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMAC 1005
+++ +C PC + N P W C + C G + C
Sbjct: 4744 -VQSDFCNSDPCPTHGNWSPWSGWGTC------------------SRTCNGGQMRRYRTC 4784
Query: 1006 YD----QNGRLV-----ETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVK 1056
+ GR + RCN+ CP D W +WS+CS SCG G K
Sbjct: 4785 DNPPPSNGGRACGGPDSQIQRCNTD---------MCPVDGSWGSWHSWSQCSASCGGGEK 4835
Query: 1057 VRSKWL-REKPYNGGRPCP 1074
R + P GGRPCP
Sbjct: 4836 TRKRLCDHPVPVKGGRPCP 4854
Score = 82.8 bits (203), Expect = 3e-15
Identities = 118/503 (23%), Positives = 164/503 (32%), Gaps = 173/503 (34%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNL-TEFQVCQSSPCEAEELRYSL 255
S++SAW CS TCG G+Q R+R P P GG C E + CQ+ PC +
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVD------ 4586
Query: 256 HVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENK 315
G WS S+ E RS G + N+ R N
Sbjct: 4587 --GSWSEWSL----------------WEECTRSCG------------RGNQTRTRTCNNP 4616
Query: 316 YWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKT 375
+Q G + E G A ++ C P+ S W W CS++
Sbjct: 4617 --SVQHGGRPCE-------GNAVEIIMCNIRPCPV---------HGAWSAWQPWGTCSES 4658
Query: 376 CHDMVSPAGTRVRTRTIRQFPIG-SEKECPEFEEKEPCLSQGDGVVPCATYG-WRT-TEW 432
C GT+ R R P C E + ++ + C +G W T W
Sbjct: 4659 C-----GKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERN----CPIHGKWATWASW 4709
Query: 433 TECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLK 492
+ C V CGGG + R C + + Q K
Sbjct: 4710 SACSVS----------------CGGGARQRTRGC----SDPVPQYGGRK----------- 4738
Query: 493 LCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGG 552
C G + PCPT SPWS WG C+ CN G ++R+ R + P
Sbjct: 4739 -CEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCS-RTCN------GGQMRRYRTCDNPPPS 4790
Query: 553 SGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC-GPGTQVQEVVCINSDGEEV 611
+G G+ C GP +Q+Q N+D
Sbjct: 4791 NG----------------------------------GRACGGPDSQIQR---CNTD---- 4809
Query: 612 DRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGE 671
CP D +W +WS CS +C G G++ R R
Sbjct: 4810 ------------------MCPVDGSWGSWHSWSQCSASCGG----GEKTRKRLCDHPVPV 4847
Query: 672 EGGIRCPNSSALQEVRSCNEHPC 694
+GG CP + +V CN C
Sbjct: 4848 KGGRPCPGDTT--QVTRCNVQAC 4868
Score = 81.6 bits (200), Expect = 6e-15
Identities = 90/361 (24%), Positives = 131/361 (36%), Gaps = 71/361 (19%)
Query: 910 TSWSKFSSCNGDCGAVRTRKRTLVGK---SKKKEKCKNSHLYPL-IETQYCPCDKYNAQP 965
+ WS + +C+ CG ++ L + + + C+ S L + + CP D
Sbjct: 4533 SQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVD------ 4586
Query: 966 VGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQN---------GRLVETS 1016
G+WS+ L E + CG+G + + C + + G VE
Sbjct: 4587 -GSWSEWSLWEECT------------RSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEII 4633
Query: 1017 RCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPK 1075
CN I PCP S W W CS+SCG G + R++ P GG C
Sbjct: 4634 MCN---------IRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDG 4684
Query: 1076 LDHVNQAQVYEVVPCHSDCNQYLWVT-EPWSICKVTFVNMRENCGEGVQTRKVRCMQNTA 1134
+ Q P H W T WS C V +CG G + R C
Sbjct: 4685 AETQMQVCNERNCPIHGK-----WATWASWSACSV-------SCGGGARQRTRGC----- 4727
Query: 1135 DGPSEHVEDYLCDPEEMPLGSRVCKL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRSADP 1193
P C+ ++ S C PCP S W W C CN R+
Sbjct: 4728 SDPVPQYGGRKCEGSDVQ--SDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCD 4785
Query: 1194 IRQPADEGRSC--PNAVEKEPCNLNKNCYHYDY-NVTDWSTCQLSEKAVCGNGIKTRMLD 1250
P++ GR+C P++ + + CN + + + WS C S CG G KTR
Sbjct: 4786 NPPPSNGGRACGGPDS-QIQRCNTDMCPVDGSWGSWHSWSQCSAS----CGGGEKTRKRL 4840
Query: 1251 C 1251
C
Sbjct: 4841 C 4841
Score = 79.3 bits (194), Expect = 3e-14
Identities = 111/411 (27%), Positives = 143/411 (34%), Gaps = 110/411 (26%)
Query: 364 SEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQ-FPIGSEKECPEFE-EKEPCLSQGDGVVP 421
S+WS W CS TC G + R+R Q P K C + E C ++ P
Sbjct: 4533 SQWSAWRACSVTCGK-----GIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNK-----P 4582
Query: 422 CATYG-WRTTE-WTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLST 479
C G W W EC T CG G QTR C +
Sbjct: 4583 CPVDGSWSEWSLWEEC----------------TRSCGRGNQTRTRTC-----------NN 4615
Query: 480 HKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGF 538
+ +P C G +C+I PCP S W WG C+ E+C KG
Sbjct: 4616 PSVQHGGRP-----CEGNAVEII-MCNIRPCPVHGAWSAWQPWGTCS-ESCG-----KGT 4663
Query: 539 KLRKRRITNEPT--GGSGVTG-----------NCP-HLLEAIPCEEPACYDWKAVRLGNC 584
+ R R N P GGS G NCP H A AC +V G
Sbjct: 4664 QTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSAC----SVSCGGG 4719
Query: 585 EPDNGKECG-PGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTW 643
+ C P Q C +G +V C PCP S WS W
Sbjct: 4720 ARQRTRGCSDPVPQYGGRKC---EGSDVQSDFCNSD----------PCPTHGNWSPWSGW 4766
Query: 644 SSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGP 703
+CS TC+G G+ R R+ GG C + +++ CN C V G
Sbjct: 4767 GTCSRTCNG----GQMRRYRTCDNPPPSNGGRACGGPDS--QIQRCNTDMCPV----DGS 4816
Query: 704 WGQCIEDTSVSSFNTTTTWNG-EASCSVGMQTRKVICVRVNVGQVGPKKCP 753
WG + +W+ ASC G +TRK +C V G + CP
Sbjct: 4817 WG------------SWHSWSQCSASCGGGEKTRKRLCDH-PVPVKGGRPCP 4854
Score = 58.2 bits (139), Expect = 7e-08
Identities = 88/361 (24%), Positives = 119/361 (32%), Gaps = 110/361 (30%)
Query: 190 PCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPP-QFGGSGCP-NLTEFQVCQSSPCE 247
PC D SE+S W EC+++CG G Q RTR P Q GG C N E +C PC
Sbjct: 4582 PCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCP 4641
Query: 248 AEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRN 307
+ PW TCS + KG +
Sbjct: 4642 VHGAWSAWQ--PWGTCS--------------------ESCGKGTQ--------------- 4664
Query: 308 RQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQV---- 363
TR +C N A S+C + M Q C + C +
Sbjct: 4665 -----------------TRARLC-NNPPPAFGGSYCDGAETQM--QVC-NERNCPIHGKW 4703
Query: 364 SEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCA 423
+ W+ WS CS +C G R RTR C + P
Sbjct: 4704 ATWASWSACSVSC-----GGGARQRTR-----------GCSD---------------PVP 4732
Query: 424 TYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNK 483
YG R E ++ + D S GN + G G +R N + + T N
Sbjct: 4733 QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSR-----TCNGGQMRRYRTCDNP 4787
Query: 484 EASKPMDLKLCTGPIPNTTQLCHIP-CPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRK 542
S + C GP + Q C+ CP + W +W C+ +C G K RK
Sbjct: 4788 PPSN--GGRACGGP-DSQIQRCNTDMCPVDGSWGSWHSWSQCS-ASCGG-----GEKTRK 4838
Query: 543 R 543
R
Sbjct: 4839 R 4839
Score = 35.0 bits (79), Expect = 0.60
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 191 CQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCP-NLTEFQVCQSSPC 246
C D + +WS+CS +CG G + R R P P GG CP + T+ C C
Sbjct: 4811 CPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQAC 4868
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 101 bits (251), Expect = 7e-21
Identities = 97/377 (25%), Positives = 145/377 (38%), Gaps = 88/377 (23%)
Query: 446 KRRGNQ--TALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPI--PNT 501
KR G+ +A CG G+ C+ ++E+ + +D + C P +
Sbjct: 669 KRVGHSACSASCGKGVWRPIFLCI--------------SRESGEELDERSCAAGARPPAS 714
Query: 502 TQLCH-IPCPTECEVSPWSAW----GPCTYEN---CNDQQGKKGFKLRKRRITNEPTGGS 553
+ CH PCP E W++ GP T C + G G + R + P
Sbjct: 715 PEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR--- 771
Query: 554 GVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDR 613
P++ ++ C+ C W+ +G+ CG G + ++V C+ ++G+EV
Sbjct: 772 ------PNITQS--CQLRLCGHWE---VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSE 820
Query: 614 QLCRDA--IFPIPVACD-APCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAY-- 668
Q C P ACD PC S WS S CS C G I+ RS++
Sbjct: 821 QECASGPPQPPSREACDMGPCTTAWFHSDWS--SKCSAEC------GTGIQRRSVVCLGS 872
Query: 669 ----------AGEEGGIRCPNSSALQEVRSCNEHPC-TVYHWQTGPWGQCIEDTSVSSFN 717
AG G CP S ++R+C+ PC + W TGPWG+C
Sbjct: 873 GAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGEC---------- 922
Query: 718 TTTTWNGEASCSVGMQTRKVICVR---VNVGQVGPKKCPESLRPETVRPCL-LPCKKDCI 773
+ C G Q R +ICV P C RP ++PC C+
Sbjct: 923 -------SSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWF 975
Query: 774 VTPYSDWTSCPSSCKEG 790
TP W+ C SC+ G
Sbjct: 976 STP---WSPCSRSCQGG 989
Score = 88.6 bits (218), Expect = 5e-17
Identities = 103/380 (27%), Positives = 146/380 (38%), Gaps = 79/380 (20%)
Query: 1117 NCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGS-RVCK-LPCPEDCVISEWGPW 1174
+CG+GV C+ + E +++ C P S C PCP E G W
Sbjct: 679 SCGKGVWRPIFLCISRES---GEELDERSCAAGARPPASPEPCHGTPCPP---YWEAGEW 732
Query: 1175 TQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPC------NLNKNCY-----HYD 1223
T C C + Q RQ G S +V E C N+ ++C H++
Sbjct: 733 TSCSRSCGPGT--QHRQLQCRQEFGGGGS---SVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 1224 YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVEC 1283
+ WS C + CG G ++R + CV ++G V + C A G + M C
Sbjct: 788 VG-SPWSQCSVR----CGRGQRSRQVRCVGNNGDEVSEQEC-ASGPPQPPSREACDMGPC 841
Query: 1284 PVNCQLSDWSPWSECSQTCGLTGKMIRRRTVT--------QPFQGD-----GRPCP--SL 1328
SDWS S+CS CG TG I+RR+V P QG+ G+ CP S
Sbjct: 842 TTAWFHSDWS--SKCSAECG-TG--IQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSR 896
Query: 1329 MDQSKPCPVKPC---YRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDE 1385
+ C + PC +RW G W C ++CG GT+ R+I CV G+
Sbjct: 897 PPDMRACSLGPCERTWRWYTGPWGECS---SECGSGTQRRDIICVSKLGT---------- 943
Query: 1386 EFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSS--WSLCQLTCVNGEDLGFGGIQV 1443
+ + N + + QPC G W S WS C +C GG Q
Sbjct: 944 ----EFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQ-------GGTQT 992
Query: 1444 RSRPVIIQELENQHLCPEQM 1463
R + CP Q+
Sbjct: 993 REVQCLSTNQTLSTRCPPQL 1012
Score = 82.4 bits (202), Expect = 3e-15
Identities = 91/367 (24%), Positives = 131/367 (35%), Gaps = 83/367 (22%)
Query: 1045 SRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCH-SDCNQYLWVTEP 1103
S CS SCG GV R +L +G + PCH + C Y W
Sbjct: 674 SACSASCGKGV-WRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPY-WEAGE 731
Query: 1104 WSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCP 1163
W+ C +CG G Q R+++C Q G S V C P ++ C+L
Sbjct: 732 WTSCS-------RSCGPGTQHRQLQCRQEFGGGGSS-VPPERCGHLPRPNITQSCQLR-- 781
Query: 1164 EDCVISEW---GPWTQCVLPCNQSSFRQRSADPIRQPADE--GRSC----PNAVEKEPCN 1214
+ W PW+QC + C + R R + DE + C P +E C+
Sbjct: 782 ---LCGHWEVGSPWSQCSVRCGRGQ-RSRQVRCVGNNGDEVSEQECASGPPQPPSREACD 837
Query: 1215 LNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRS-------------------- 1254
+ + + +DWS+ A CG GI+ R + C+ S
Sbjct: 838 MGPCTTAWFH--SDWSS---KCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCP 892
Query: 1255 -DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCG---------L 1304
+ D++ C E+ W+ T PW ECS CG
Sbjct: 893 TGSRPPDMRACSLGPCERTWRWYT---------------GPWGECSSECGSGTQRRDIIC 937
Query: 1305 TGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPCY-RWQYGQWSPCQVQEAQCGEGTR 1363
K+ VT P P P + +PC + C RW WSPC C GT+
Sbjct: 938 VSKLGTEFNVTSPSNCSHLPRPPAL---QPCQGQACQDRWFSTPWSPC---SRSCQGGTQ 991
Query: 1364 TRNISCV 1370
TR + C+
Sbjct: 992 TREVQCL 998
Score = 79.7 bits (195), Expect = 2e-14
Identities = 82/338 (24%), Positives = 128/338 (37%), Gaps = 62/338 (18%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCP--KLDHVNQAQVYEVV 1088
PCP + EW++ CS+SCG G + R R++ GG P + H+ + + +
Sbjct: 722 PCPPYWEAGEWTS---CSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQ-- 776
Query: 1089 PCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDP 1148
C + V PWS C V CG G ++R+VRC+ N D SE ++ P
Sbjct: 777 SCQLRLCGHWEVGSPWSQCSV-------RCGRGQRSRQVRCVGNNGDEVSE--QECASGP 827
Query: 1149 EEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPI-----------RQP 1197
+ P PC S+W ++C C + ++RS +
Sbjct: 828 PQPPSREACDMGPCTTAWFHSDWS--SKCSAECG-TGIQRRSVVCLGSGAALGPGQGEAG 884
Query: 1198 ADEGRSCPNA---VEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRS 1254
A G+SCP + C+L + + W C + CG+G + R + CV
Sbjct: 885 AGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGEC----SSECGSGTQRRDIICV-- 938
Query: 1255 DGKSVDLKYCEALGLEKNWQMNTSC--------MVECPVNCQLSDW--SPWSECSQTCGL 1304
LG E N ++C + C W +PWS CS++C
Sbjct: 939 ----------SKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSC-Q 987
Query: 1305 TGKMIRRRTVTQPFQGDGRPCPSLM--DQSKPCPVKPC 1340
G R Q CP + + +PC +PC
Sbjct: 988 GGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
Score = 74.7 bits (182), Expect = 7e-13
Identities = 99/406 (24%), Positives = 143/406 (35%), Gaps = 81/406 (19%)
Query: 124 WRLGPWNQCQPVISKSLEKPLE-CIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPL 182
W+ + C K + +P+ CI E G ++ E +C + PA C P
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARP-PASPEPCHGTPCPPY 726
Query: 183 LEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGC---------- 232
E W+ CS++CG G QHR + +FGG G
Sbjct: 727 WEAG---------------EWTSCSRSCGPGTQHR--QLQCRQEFGGGGSSVPPERCGHL 769
Query: 233 --PNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSR--QVRQARRRGKNKER--EKD 286
PN+T Q CQ C E+ PWS CS+ R + RQ R G N + E++
Sbjct: 770 PRPNIT--QSCQLRLCGHWEVG-----SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE 822
Query: 287 RSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQI------GYQTREVMCINKTGKAADL 340
+ G P +RE + W + G Q R V+C+ G A L
Sbjct: 823 CASGPPQPPSREACDMGPCTTAWFHSD---WSSKCSAECGTGIQRRSVVCL---GSGAAL 876
Query: 341 SFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAG---TRVRTRTIRQFPI 397
Q E T QSC PC +T P G + + T R+ I
Sbjct: 877 GPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDII 936
Query: 398 GSEKECPEFEEKEPC----LSQGDGVVPCATYG----WRTTEWTECRVDPLLSQQDKRRG 449
K EF P L + + PC W +T W+ C
Sbjct: 937 CVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPC-------------- 982
Query: 450 NQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCT 495
+ C GG QTREV C+ N+ L ++ +P + + C+
Sbjct: 983 --SRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCS 1026
Score = 72.8 bits (177), Expect = 3e-12
Identities = 100/387 (25%), Positives = 147/387 (37%), Gaps = 70/387 (18%)
Query: 329 MCINK-TGKAADLSFCQQ-EKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTR 386
+CI++ +G+ D C + P + + C T E EW+ CS++C GT+
Sbjct: 690 LCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGP-----GTQ 744
Query: 387 VRTRTIRQ-FPIGSEKECPEF--EEKEPCLSQGDGVVPCATYGWRT-TEWTECRVDPLLS 442
R RQ F G PE P ++Q + C W + W++C V
Sbjct: 745 HRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH--WEVGSPWSQCSVR---- 798
Query: 443 QQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTT 502
CG G ++R+V CV N + +S+ AS P P P +
Sbjct: 799 ------------CGRGQRSRQVRCVGNNGDEVSEQEC-----ASGP--------PQPPSR 833
Query: 503 QLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGV------ 555
+ C + PC T S WS+ C+ E Q + L G +G
Sbjct: 834 EACDMGPCTTAWFHSDWSS--KCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSC 891
Query: 556 -TGNCPHLLEAI---PCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEV 611
TG+ P + A PCE + W G C ECG GTQ ++++C++ G E
Sbjct: 892 PTGSRPPDMRACSLGPCERT--WRWYTGPWGECS----SECGSGTQRRDIICVSKLGTEF 945
Query: 612 D-RQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAY 668
+ + P P A PC W + WS CS +C G G Q R L+
Sbjct: 946 NVTSPSNCSHLPRPPALQ-PCQGQACQDRWFSTPWSPCSRSCQG----GTQTREVQCLS- 999
Query: 669 AGEEGGIRCPNSSALQEVRSCNEHPCT 695
+ RCP R CN PC+
Sbjct: 1000 TNQTLSTRCPPQLRPSRKRPCNSQPCS 1026
Score = 70.9 bits (172), Expect = 1e-11
Identities = 92/401 (22%), Positives = 139/401 (34%), Gaps = 81/401 (20%)
Query: 726 ASCSVGMQTRKVICVRVNVGQ-VGPKKCPESLRPE-TVRPCL-LPCKKDCIVTPY---SD 779
ASC G+ +C+ G+ + + C RP + PC PC PY +
Sbjct: 678 ASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP------PYWEAGE 731
Query: 780 WTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHK 839
WTSC SC G + Q R GG + P P+ C + + +
Sbjct: 732 WTSCSRSCGPGTQHRQLQCRQEF-------GGGGSSVP---------PERC-GHLPRPNI 774
Query: 840 WRRCQLV---PWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALT 896
+ CQL W V CG G+++R + C +G + EC P P
Sbjct: 775 TQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECAS-GPPQPPSR 833
Query: 897 QACQI-PCQDDCQLTSWSKFSSCNGDCG-AVRTRKRTLVGK------------SKKKEKC 942
+AC + PC + WS S C+ +CG ++ R +G + + C
Sbjct: 834 EACDMGPCTTAWFHSDWS--SKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSC 891
Query: 943 KNSHLYPLIETQYC---PCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYR 999
P + + C PC++ G W +C ECG G +
Sbjct: 892 PTGSRPP--DMRACSLGPCERTWRWYTGPWGEC------------------SSECGSGTQ 931
Query: 1000 YQAMACYDQNG-RLVETSRCNSHGYIEEACIIPCPSDCKLSEW--SNWSRCSKSCGSGVK 1056
+ + C + G TS N + PC W + WS CS+SC G +
Sbjct: 932 RRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQ 991
Query: 1057 VRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSD-CNQ 1096
R CP Q + PC+S C+Q
Sbjct: 992 TREVQCLSTNQTLSTRCPP-----QLRPSRKRPCNSQPCSQ 1027
Score = 47.0 bits (110), Expect = 2e-04
Identities = 40/131 (30%), Positives = 53/131 (40%), Gaps = 26/131 (19%)
Query: 41 RPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGW---TTLHT 97
RP RA + G E + W TGPWG C ECG G Q R + C G T +
Sbjct: 896 RPPDMRACSLGPCERT--WRWYTGPWGEC-SSECG-SGTQRRDIICVSKLGTEFNVTSPS 951
Query: 98 NCKQAERPNNQQNC-FKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVR 156
NC RP Q C + C W PW+ C S+S + G Q R
Sbjct: 952 NCSHLPRPPALQPCQGQACQDR-----WFSTPWSPC----SRSC---------QGGTQTR 993
Query: 157 EIACIQKDKDI 167
E+ C+ ++ +
Sbjct: 994 EVQCLSTNQTL 1004
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 100 bits (249), Expect = 1e-20
Identities = 98/353 (27%), Positives = 137/353 (38%), Gaps = 50/353 (14%)
Query: 1033 PSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS 1092
P+D + S+ CS +C +GV S + Y+G ++D + P H
Sbjct: 562 PADMYRWKLSSHEPCSATCTTGVM--SAYAMCVRYDG----VEVDDSYCDALTRPEPVHE 615
Query: 1093 DCN----QYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDP 1148
C Q W T WS C T CGEG Q R VRC + + G V LC+
Sbjct: 616 FCAGRECQPRWETSSWSECSRT-------CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 1149 EEM--PLGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCP 1205
E P + C+ P C +SEW ++C C + S R IR DE P
Sbjct: 669 AEAVRPEERKTCRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLCDP 722
Query: 1206 NAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCE 1265
N N + V+DW C S CG G R + C SDG+ V C+
Sbjct: 723 NTRPVGEKNCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQ 778
Query: 1266 ALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPC 1325
K ++ CP + DW C+ TCG + +++R V +G+P
Sbjct: 779 ME--TKPLAIHPCGDKNCPAHWLAQDWE---RCNTTCG---RGVKKRLVLCMELANGKPQ 830
Query: 1326 ----PSLMDQSKP-----CPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISC 1369
P KP C +PC++W WS C CG G R R++ C
Sbjct: 831 TRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC 880
Score = 97.8 bits (242), Expect = 8e-20
Identities = 96/368 (26%), Positives = 148/368 (40%), Gaps = 58/368 (15%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLS-EWSNWSRCSKSCG 1052
C G C +G V+ S C++ E +C+ E S+WS CS++CG
Sbjct: 580 CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCG 639
Query: 1053 SGVKVRSK--WLREKP-YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKV 1109
G + R W P ++ + + E C + W WS C
Sbjct: 640 EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA 699
Query: 1110 TFVNMRENCGE-GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK-LPCPEDCV 1167
CGE V TR +RC + ++ LCDP P+G + C PC
Sbjct: 700 -------KCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEKNCTGPPCDRQWT 742
Query: 1168 ISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA---VEKEPCNLN----KNCY 1220
+S+WGP C+ S + R+ + +GR P + +E +P ++ KNC
Sbjct: 743 VSDWGP-------CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
Query: 1221 HYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
+ + DW C + CG G+K R++ C+ + GL K ++C
Sbjct: 796 AH-WLAQDWERCNTT----CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 850
Query: 1281 VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG--RPCPSLMD-------Q 1331
E P C SPWSEC++TCG+ +R R V + +QG R C L+
Sbjct: 851 -ERP--CFKWYTSPWSECTKTCGVG---VRMRDV-KCYQGTDIVRGCDPLVKPVGRQACD 903
Query: 1332 SKPCPVKP 1339
+PCP +P
Sbjct: 904 LQPCPTEP 911
Score = 76.6 bits (187), Expect = 2e-13
Identities = 85/365 (23%), Positives = 127/365 (34%), Gaps = 106/365 (29%)
Query: 427 WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQA-----NENLLSQLSTHK 481
W T+ W+EC + CG G Q R V C + + ++ S L +
Sbjct: 626 WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--E 667
Query: 482 NKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
EA +P + K C P C + E+S WS C + G++ R
Sbjct: 668 AAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTAKCGERSVVTR 709
Query: 542 KRRITNE---------PTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC 592
R + + P G TG PC+ W G C C
Sbjct: 710 DIRCSEDEKLCDPNTRPVGEKNCTGP--------PCDR----QWTVSDWGPCSGS----C 753
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTC 650
G G ++ V C SDG V C+ P+ + PC + W W C+ TC
Sbjct: 754 GQGRTIRHVYCKTSDGRVVPESQCQMETKPLAI---HPCGDKNCPAHWLAQDWERCNTTC 810
Query: 651 SGKTTEGKQIRARSILAYAGEEG------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPW 704
G+ ++ R +L G G C + E +C E PC + W T PW
Sbjct: 811 ------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPW 862
Query: 705 GQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC 764
+C + +C VG++ R V C + G + C ++P + C
Sbjct: 863 SECTK-----------------TCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQAC 902
Query: 765 -LLPC 768
L PC
Sbjct: 903 DLQPC 907
Score = 74.7 bits (182), Expect = 7e-13
Identities = 93/385 (24%), Positives = 131/385 (34%), Gaps = 124/385 (32%)
Query: 1238 AVCGNGIKTRMLDCVRSDGKSVDLKYCEAL-----------GLEKNWQMNTSCMVECPVN 1286
A C G+ + CVR DG VD YC+AL G E + TS EC
Sbjct: 578 ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRT 637
Query: 1287 C-------------QLS-----------------------------------DWSPWSEC 1298
C LS + S WSEC
Sbjct: 638 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 1299 SQTCGLTGKMIRRRTVTQPFQ--GDGRPCPSLMDQSKPCPVKPC------YRWQYGQWSP 1350
+ CG R VT+ + D + C ++P K C +W W P
Sbjct: 698 TAKCG------ERSVVTRDIRCSEDEKLCD---PNTRPVGEKNCTGPPCDRQWTVSDWGP 748
Query: 1351 CQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP 1410
C CG+G R++ C SDG +VV E C +E K + + +
Sbjct: 749 C---SGSCGQGRTIRHVYCKTSDG------RVVPESQC-QME-----TKPLAIHPCGDKN 793
Query: 1411 CPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELEN----QHLCPEQMLET 1466
CP +DW C TC G V+ R V+ EL N PE L
Sbjct: 794 CPAHWLAQDWER---CNTTCGRG---------VKKRLVLCMELANGKPQTRSGPECGLAK 841
Query: 1467 KSCYDGQCYE---YKWMASAWKGSSRT---------VWCQRSDGINVTGGCLVMSQPDAD 1514
K + C+E +KW S W ++T V C + G ++ GC + +P
Sbjct: 842 KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRGCDPLVKPVGR 899
Query: 1515 RSCN-PPC--SQPHSYCSETKTCHC 1536
++C+ PC P C + +C
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNC 924
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/386 (22%), Positives = 136/386 (35%), Gaps = 98/386 (25%)
Query: 120 ELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF-E 178
++Y W+L C + G+ C++ D + +D C+
Sbjct: 564 DMYRWKLSSHEPCSATCTT-------------GVMSAYAMCVRYD-GVEVDDSYCDALTR 609
Query: 179 PKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHV--VAPPQFGGSGCPNLT 236
P+P+ E CQ E S+WSECS+TCG G Q R + P F S +L
Sbjct: 610 PEPVHEFCAGRECQPRW---ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 666
Query: 237 EF---------QVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDR 287
E + C++ C + + WS C+ + R ++
Sbjct: 667 EAAEAVRPEERKTCRNPACGPQ-----WEMSEWSECT------AKCGERSVVTRDIRCSE 715
Query: 288 SKGVKDPEARELIKKKRNRNRQNRQENKYWDIQ----------IGYQTREVMCINKTGKA 337
+ + DP R + +K +RQ W + G R V C G+
Sbjct: 716 DEKLCDPNTRPVGEKNCTGPPCDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
Query: 338 ADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHDMVSPAGTRVRTRTIRQF 395
S CQ E P+ C K C + W +W C+ TC G V+ R +
Sbjct: 772 VPESQCQMETKPLAIHPCG-DKNCP-AHWLAQDWERCNTTC-------GRGVKKRLVLCM 822
Query: 396 PIGSEK-------EC---PEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQD 445
+ + K EC + E+ C + PC + W T+ W+EC
Sbjct: 823 ELANGKPQTRSGPECGLAKKPPEESTCFER-----PC--FKWYTSPWSEC---------- 865
Query: 446 KRRGNQTALCGGGIQTREVYCVQANE 471
T CG G++ R+V C Q +
Sbjct: 866 ------TKTCGVGVRMRDVKCYQGTD 885
Score = 63.5 bits (153), Expect = 2e-09
Identities = 99/376 (26%), Positives = 139/376 (36%), Gaps = 86/376 (22%)
Query: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPK 633
Y WK L + EP + C G +C+ DG EVD C P PV + +
Sbjct: 566 YRWK---LSSHEPCSAT-CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH-EFCAGR 620
Query: 634 DCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQ-EVR 687
+C W S+WS CS TC G+ + + +R +L+ G + + C + A++ E R
Sbjct: 621 EC-QPRWETSSWSECSRTC-GEGYQFRVVRCWKMLS-PGFDSSVYSDLCEAAEAVRPEER 677
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
+P W+ W +C T GE S + TR + C
Sbjct: 678 KTCRNPACGPQWEMSEWSEC------------TAKCGERS----VVTRDIRC------SE 715
Query: 748 GPKKCPESLRPETVRPCL-LPCKKDCIVTPYSDWTSCPSSCKEGDSSIR----KQSRHRV 802
K C + RP + C PC + V SDW C SC +G +IR K S RV
Sbjct: 716 DEKLCDPNTRPVGEKNCTGPPCDRQWTV---SDWGPCSGSCGQG-RTIRHVYCKTSDGRV 771
Query: 803 IIQLPANGGRDCTDPL----YEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQ 858
+ P + + T PL +K C A W W RC
Sbjct: 772 V---PESQCQMETKPLAIHPCGDKNCPA-------HWLAQDWERCNTT------------ 809
Query: 859 EGCGPGRQARAITCRKQDGGQAGIH---ECLQYAGPVPALTQACQIPCQDDCQLTSW--S 913
CG G + R + C + G+ EC A P + + PC W S
Sbjct: 810 --CGRGVKKRLVLCMELANGKPQTRSGPEC-GLAKKPPEESTCFERPC------FKWYTS 860
Query: 914 KFSSCNGDCG-AVRTR 928
+S C CG VR R
Sbjct: 861 PWSECTKTCGVGVRMR 876
Score = 52.8 bits (125), Expect = 3e-06
Identities = 97/419 (23%), Positives = 136/419 (32%), Gaps = 102/419 (24%)
Query: 643 WSSCSHT-CSGKTTEGKQIRARSILAYAGEE-GGIRCPNSSALQEVRS-CNEHPCTVYHW 699
W SH CS T G + Y G E C + + V C C W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP-RW 626
Query: 700 QTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNV----GQVGPKKCP-- 753
+T W +C +C G Q R V C ++ V C
Sbjct: 627 ETSSWSEC-----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 669
Query: 754 ESLRPETVRPCLLP-CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGR 812
E++RPE + C P C + S+W+ C + C E R V + +
Sbjct: 670 EAVRPEERKTCRNPACGPQWEM---SEWSECTAKCGE---------RSVVTRDIRCSEDE 717
Query: 813 DCTDPLYE---EKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
DP EK C P + +W W C CG GR R
Sbjct: 718 KLCDPNTRPVGEKNCTGPPCDR--QWTVSDWGPCS--------------GSCGQGRTIRH 761
Query: 870 ITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCGAVRT 927
+ C+ DG +C P+ PC D W + CN CG R
Sbjct: 762 VYCKTSDGRVVPESQCQMETKPLAIH------PCGDKNCPAHWLAQDWERCNTTCG--RG 813
Query: 928 RKRTLV-------GKSKKKE--KCKNSHLYPLIETQY-CPCDKYNAQPVGNWSDCILPEG 977
K+ LV GK + + +C + P T + PC K+ P WS+C
Sbjct: 814 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP---WSECT---- 866
Query: 978 KVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEAC-IIPCPSD 1035
K CG G R + + CY Q +V +AC + PCP++
Sbjct: 867 --------------KTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
Score = 50.4 bits (119), Expect = 1e-05
Identities = 61/294 (20%), Positives = 100/294 (34%), Gaps = 94/294 (31%)
Query: 992 KECGQGYRYQAMACYDQNG----RLVETSRCNSHGYI----EEACIIP-CPSDCKLSEW- 1041
+ CG+GY+++ + C+ V + C + + + C P C ++SEW
Sbjct: 636 RTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS 695
Query: 1042 ------------------------------------------------SNWSRCSKSCGS 1053
S+W CS SCG
Sbjct: 696 ECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 755
Query: 1054 GVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVN 1113
G +R + + + GR P+ + + + PC W+ + W C T
Sbjct: 756 GRTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT--- 809
Query: 1114 MRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC-KLPCPEDCVISEW- 1171
CG GV+ R V CM+ A+G + C + P C + PC +W
Sbjct: 810 ----CGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWY 858
Query: 1172 -GPWTQCV-----------LPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPC 1213
PW++C + C Q + R DP+ +P GR A + +PC
Sbjct: 859 TSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV--GR---QACDLQPC 907
Score = 42.0 bits (97), Expect = 0.005
Identities = 34/135 (25%), Positives = 54/135 (40%), Gaps = 29/135 (21%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWC---AHVEGWTTLHTNCKQAERPNNQQNCFKVCDW 117
W W RC CG G ++ R V C A+ + T C A++P + CF+
Sbjct: 798 WLAQDWERC-NTTCGRG-VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFE---- 851
Query: 118 HKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF 177
+ + W PW++C G+++R++ C Q + D +
Sbjct: 852 -RPCFKWYTSPWSECTKTCG-------------VGVRMRDVKCYQGTDIVRGCDPLV--- 894
Query: 178 EPKPLLEQAC-LIPC 191
KP+ QAC L PC
Sbjct: 895 --KPVGRQACDLQPC 907
Score = 33.5 bits (75), Expect = 1.8
Identities = 22/83 (26%), Positives = 35/83 (42%), Gaps = 20/83 (24%)
Query: 365 EWSEWSPCSKTC---------------HDMVSPAGTRVRTRTIRQFPIGSEKECP----E 405
EW++W+ CS++C V G R T T +++ + +ECP
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRS 111
Query: 406 FEEKEPCLSQGDGVVPCATYGWR 428
F E E C+S V T+ W+
Sbjct: 112 FRE-EQCVSFNSHVYNGRTHQWK 133
Score = 33.5 bits (75), Expect = 1.8
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 199 EFSAWSECSKTCGSGLQHRTRHVV-----APPQFGGSGCPNLTE-FQVCQSSPC 246
E++ W+ CS++CG G+ + RH + + P G C ++ +Q+C+ C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 33.5 bits (75), Expect = 1.8
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 5/39 (12%)
Query: 1040 EWSNWSRCSKSCGSGVKVRSKWLREK-----PYNGGRPC 1073
EW+ W+ CS+SCG GV + + ++ P G R C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC 90
Score = 32.0 bits (71), Expect = 5.1
Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 777 YSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC---EAP------ 827
++ WT+C SC G +S + + +P G R CT + C E P
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSF 112
Query: 828 --QACQS-----YRWKTHKWR 841
+ C S Y +TH+W+
Sbjct: 113 REEQCVSFNSHVYNGRTHQWK 133
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 100 bits (249), Expect = 1e-20
Identities = 98/353 (27%), Positives = 137/353 (38%), Gaps = 50/353 (14%)
Query: 1033 PSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS 1092
P+D + S+ CS +C +GV S + Y+G ++D + P H
Sbjct: 562 PADMYRWKLSSHEPCSATCTTGVM--SAYAMCVRYDG----VEVDDSYCDALTRPEPVHE 615
Query: 1093 DCN----QYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDP 1148
C Q W T WS C T CGEG Q R VRC + + G V LC+
Sbjct: 616 FCAGRECQPRWETSSWSECSRT-------CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 1149 EEM--PLGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCP 1205
E P + C+ P C +SEW ++C C + S R IR DE P
Sbjct: 669 AEAVRPEERKTCRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLCDP 722
Query: 1206 NAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCE 1265
N N + V+DW C S CG G R + C SDG+ V C+
Sbjct: 723 NTRPVGEKNCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQ 778
Query: 1266 ALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPC 1325
K ++ CP + DW C+ TCG + +++R V +G+P
Sbjct: 779 ME--TKPLAIHPCGDKNCPAHWLAQDWE---RCNTTCG---RGVKKRLVLCMELANGKPQ 830
Query: 1326 ----PSLMDQSKP-----CPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISC 1369
P KP C +PC++W WS C CG G R R++ C
Sbjct: 831 TRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC 880
Score = 97.8 bits (242), Expect = 8e-20
Identities = 96/368 (26%), Positives = 148/368 (40%), Gaps = 58/368 (15%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLS-EWSNWSRCSKSCG 1052
C G C +G V+ S C++ E +C+ E S+WS CS++CG
Sbjct: 580 CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCG 639
Query: 1053 SGVKVRSK--WLREKP-YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKV 1109
G + R W P ++ + + E C + W WS C
Sbjct: 640 EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA 699
Query: 1110 TFVNMRENCGE-GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK-LPCPEDCV 1167
CGE V TR +RC + ++ LCDP P+G + C PC
Sbjct: 700 -------KCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEKNCTGPPCDRQWT 742
Query: 1168 ISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA---VEKEPCNLN----KNCY 1220
+S+WGP C+ S + R+ + +GR P + +E +P ++ KNC
Sbjct: 743 VSDWGP-------CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
Query: 1221 HYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
+ + DW C + CG G+K R++ C+ + GL K ++C
Sbjct: 796 AH-WLAQDWERCNTT----CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 850
Query: 1281 VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG--RPCPSLMD-------Q 1331
E P C SPWSEC++TCG+ +R R V + +QG R C L+
Sbjct: 851 -ERP--CFKWYTSPWSECTKTCGVG---VRMRDV-KCYQGTDIVRGCDPLVKPVGRQACD 903
Query: 1332 SKPCPVKP 1339
+PCP +P
Sbjct: 904 LQPCPTEP 911
Score = 76.6 bits (187), Expect = 2e-13
Identities = 85/365 (23%), Positives = 127/365 (34%), Gaps = 106/365 (29%)
Query: 427 WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQA-----NENLLSQLSTHK 481
W T+ W+EC + CG G Q R V C + + ++ S L +
Sbjct: 626 WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--E 667
Query: 482 NKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
EA +P + K C P C + E+S WS C + G++ R
Sbjct: 668 AAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTAKCGERSVVTR 709
Query: 542 KRRITNE---------PTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC 592
R + + P G TG PC+ W G C C
Sbjct: 710 DIRCSEDEKLCDPNTRPVGEKNCTGP--------PCDR----QWTVSDWGPCSGS----C 753
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTC 650
G G ++ V C SDG V C+ P+ + PC + W W C+ TC
Sbjct: 754 GQGRTIRHVYCKTSDGRVVPESQCQMETKPLAI---HPCGDKNCPAHWLAQDWERCNTTC 810
Query: 651 SGKTTEGKQIRARSILAYAGEEG------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPW 704
G+ ++ R +L G G C + E +C E PC + W T PW
Sbjct: 811 ------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPW 862
Query: 705 GQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC 764
+C + +C VG++ R V C + G + C ++P + C
Sbjct: 863 SECTK-----------------TCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQAC 902
Query: 765 -LLPC 768
L PC
Sbjct: 903 DLQPC 907
Score = 74.7 bits (182), Expect = 7e-13
Identities = 93/385 (24%), Positives = 131/385 (34%), Gaps = 124/385 (32%)
Query: 1238 AVCGNGIKTRMLDCVRSDGKSVDLKYCEAL-----------GLEKNWQMNTSCMVECPVN 1286
A C G+ + CVR DG VD YC+AL G E + TS EC
Sbjct: 578 ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRT 637
Query: 1287 C-------------QLS-----------------------------------DWSPWSEC 1298
C LS + S WSEC
Sbjct: 638 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 1299 SQTCGLTGKMIRRRTVTQPFQ--GDGRPCPSLMDQSKPCPVKPC------YRWQYGQWSP 1350
+ CG R VT+ + D + C ++P K C +W W P
Sbjct: 698 TAKCG------ERSVVTRDIRCSEDEKLCD---PNTRPVGEKNCTGPPCDRQWTVSDWGP 748
Query: 1351 CQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP 1410
C CG+G R++ C SDG +VV E C +E K + + +
Sbjct: 749 C---SGSCGQGRTIRHVYCKTSDG------RVVPESQC-QME-----TKPLAIHPCGDKN 793
Query: 1411 CPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELEN----QHLCPEQMLET 1466
CP +DW C TC G V+ R V+ EL N PE L
Sbjct: 794 CPAHWLAQDWER---CNTTCGRG---------VKKRLVLCMELANGKPQTRSGPECGLAK 841
Query: 1467 KSCYDGQCYE---YKWMASAWKGSSRT---------VWCQRSDGINVTGGCLVMSQPDAD 1514
K + C+E +KW S W ++T V C + G ++ GC + +P
Sbjct: 842 KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRGCDPLVKPVGR 899
Query: 1515 RSCN-PPC--SQPHSYCSETKTCHC 1536
++C+ PC P C + +C
Sbjct: 900 QACDLQPCPTEPPDDSCQDQPGTNC 924
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/386 (22%), Positives = 136/386 (35%), Gaps = 98/386 (25%)
Query: 120 ELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF-E 178
++Y W+L C + G+ C++ D + +D C+
Sbjct: 564 DMYRWKLSSHEPCSATCTT-------------GVMSAYAMCVRYD-GVEVDDSYCDALTR 609
Query: 179 PKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHV--VAPPQFGGSGCPNLT 236
P+P+ E CQ E S+WSECS+TCG G Q R + P F S +L
Sbjct: 610 PEPVHEFCAGRECQPRW---ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 666
Query: 237 EF---------QVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDR 287
E + C++ C + + WS C+ + R ++
Sbjct: 667 EAAEAVRPEERKTCRNPACGPQ-----WEMSEWSECT------AKCGERSVVTRDIRCSE 715
Query: 288 SKGVKDPEARELIKKKRNRNRQNRQENKYWDIQ----------IGYQTREVMCINKTGKA 337
+ + DP R + +K +RQ W + G R V C G+
Sbjct: 716 DEKLCDPNTRPVGEKNCTGPPCDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 771
Query: 338 ADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHDMVSPAGTRVRTRTIRQF 395
S CQ E P+ C K C + W +W C+ TC G V+ R +
Sbjct: 772 VPESQCQMETKPLAIHPCG-DKNCP-AHWLAQDWERCNTTC-------GRGVKKRLVLCM 822
Query: 396 PIGSEK-------EC---PEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQD 445
+ + K EC + E+ C + PC + W T+ W+EC
Sbjct: 823 ELANGKPQTRSGPECGLAKKPPEESTCFER-----PC--FKWYTSPWSEC---------- 865
Query: 446 KRRGNQTALCGGGIQTREVYCVQANE 471
T CG G++ R+V C Q +
Sbjct: 866 ------TKTCGVGVRMRDVKCYQGTD 885
Score = 63.5 bits (153), Expect = 2e-09
Identities = 99/376 (26%), Positives = 139/376 (36%), Gaps = 86/376 (22%)
Query: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPK 633
Y WK L + EP + C G +C+ DG EVD C P PV + +
Sbjct: 566 YRWK---LSSHEPCSAT-CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH-EFCAGR 620
Query: 634 DCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQ-EVR 687
+C W S+WS CS TC G+ + + +R +L+ G + + C + A++ E R
Sbjct: 621 EC-QPRWETSSWSECSRTC-GEGYQFRVVRCWKMLS-PGFDSSVYSDLCEAAEAVRPEER 677
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
+P W+ W +C T GE S + TR + C
Sbjct: 678 KTCRNPACGPQWEMSEWSEC------------TAKCGERS----VVTRDIRC------SE 715
Query: 748 GPKKCPESLRPETVRPCL-LPCKKDCIVTPYSDWTSCPSSCKEGDSSIR----KQSRHRV 802
K C + RP + C PC + V SDW C SC +G +IR K S RV
Sbjct: 716 DEKLCDPNTRPVGEKNCTGPPCDRQWTV---SDWGPCSGSCGQG-RTIRHVYCKTSDGRV 771
Query: 803 IIQLPANGGRDCTDPL----YEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQ 858
+ P + + T PL +K C A W W RC
Sbjct: 772 V---PESQCQMETKPLAIHPCGDKNCPA-------HWLAQDWERCNTT------------ 809
Query: 859 EGCGPGRQARAITCRKQDGGQAGIH---ECLQYAGPVPALTQACQIPCQDDCQLTSW--S 913
CG G + R + C + G+ EC A P + + PC W S
Sbjct: 810 --CGRGVKKRLVLCMELANGKPQTRSGPEC-GLAKKPPEESTCFERPC------FKWYTS 860
Query: 914 KFSSCNGDCG-AVRTR 928
+S C CG VR R
Sbjct: 861 PWSECTKTCGVGVRMR 876
Score = 52.8 bits (125), Expect = 3e-06
Identities = 97/419 (23%), Positives = 136/419 (32%), Gaps = 102/419 (24%)
Query: 643 WSSCSHT-CSGKTTEGKQIRARSILAYAGEE-GGIRCPNSSALQEVRS-CNEHPCTVYHW 699
W SH CS T G + Y G E C + + V C C W
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP-RW 626
Query: 700 QTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNV----GQVGPKKCP-- 753
+T W +C +C G Q R V C ++ V C
Sbjct: 627 ETSSWSEC-----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 669
Query: 754 ESLRPETVRPCLLP-CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGR 812
E++RPE + C P C + S+W+ C + C E R V + +
Sbjct: 670 EAVRPEERKTCRNPACGPQWEM---SEWSECTAKCGE---------RSVVTRDIRCSEDE 717
Query: 813 DCTDPLYE---EKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
DP EK C P + +W W C CG GR R
Sbjct: 718 KLCDPNTRPVGEKNCTGPPCDR--QWTVSDWGPCS--------------GSCGQGRTIRH 761
Query: 870 ITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCGAVRT 927
+ C+ DG +C P+ PC D W + CN CG R
Sbjct: 762 VYCKTSDGRVVPESQCQMETKPLAIH------PCGDKNCPAHWLAQDWERCNTTCG--RG 813
Query: 928 RKRTLV-------GKSKKKE--KCKNSHLYPLIETQY-CPCDKYNAQPVGNWSDCILPEG 977
K+ LV GK + + +C + P T + PC K+ P WS+C
Sbjct: 814 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP---WSECT---- 866
Query: 978 KVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEAC-IIPCPSD 1035
K CG G R + + CY Q +V +AC + PCP++
Sbjct: 867 --------------KTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCPTE 910
Score = 50.4 bits (119), Expect = 1e-05
Identities = 61/294 (20%), Positives = 100/294 (34%), Gaps = 94/294 (31%)
Query: 992 KECGQGYRYQAMACYDQNG----RLVETSRCNSHGYI----EEACIIP-CPSDCKLSEW- 1041
+ CG+GY+++ + C+ V + C + + + C P C ++SEW
Sbjct: 636 RTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS 695
Query: 1042 ------------------------------------------------SNWSRCSKSCGS 1053
S+W CS SCG
Sbjct: 696 ECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 755
Query: 1054 GVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVN 1113
G +R + + + GR P+ + + + PC W+ + W C T
Sbjct: 756 GRTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT--- 809
Query: 1114 MRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC-KLPCPEDCVISEW- 1171
CG GV+ R V CM+ A+G + C + P C + PC +W
Sbjct: 810 ----CGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWY 858
Query: 1172 -GPWTQCV-----------LPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPC 1213
PW++C + C Q + R DP+ +P GR A + +PC
Sbjct: 859 TSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV--GR---QACDLQPC 907
Score = 42.0 bits (97), Expect = 0.005
Identities = 34/135 (25%), Positives = 54/135 (40%), Gaps = 29/135 (21%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWC---AHVEGWTTLHTNCKQAERPNNQQNCFKVCDW 117
W W RC CG G ++ R V C A+ + T C A++P + CF+
Sbjct: 798 WLAQDWERC-NTTCGRG-VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFE---- 851
Query: 118 HKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF 177
+ + W PW++C G+++R++ C Q + D +
Sbjct: 852 -RPCFKWYTSPWSECTKTCG-------------VGVRMRDVKCYQGTDIVRGCDPLV--- 894
Query: 178 EPKPLLEQAC-LIPC 191
KP+ QAC L PC
Sbjct: 895 --KPVGRQACDLQPC 907
Score = 33.5 bits (75), Expect = 1.8
Identities = 22/83 (26%), Positives = 35/83 (42%), Gaps = 20/83 (24%)
Query: 365 EWSEWSPCSKTC---------------HDMVSPAGTRVRTRTIRQFPIGSEKECP----E 405
EW++W+ CS++C V G R T T +++ + +ECP
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRS 111
Query: 406 FEEKEPCLSQGDGVVPCATYGWR 428
F E E C+S V T+ W+
Sbjct: 112 FRE-EQCVSFNSHVYNGRTHQWK 133
Score = 33.5 bits (75), Expect = 1.8
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 199 EFSAWSECSKTCGSGLQHRTRHVV-----APPQFGGSGCPNLTE-FQVCQSSPC 246
E++ W+ CS++CG G+ + RH + + P G C ++ +Q+C+ C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 33.5 bits (75), Expect = 1.8
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 5/39 (12%)
Query: 1040 EWSNWSRCSKSCGSGVKVRSKWLREK-----PYNGGRPC 1073
EW+ W+ CS+SCG GV + + ++ P G R C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTC 90
Score = 32.0 bits (71), Expect = 5.1
Identities = 21/81 (25%), Positives = 33/81 (40%), Gaps = 16/81 (19%)
Query: 777 YSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC---EAP------ 827
++ WT+C SC G +S + + +P G R CT + C E P
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSF 112
Query: 828 --QACQS-----YRWKTHKWR 841
+ C S Y +TH+W+
Sbjct: 113 REEQCVSFNSHVYNGRTHQWK 133
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 100 bits (249), Expect = 1e-20
Identities = 98/353 (27%), Positives = 137/353 (38%), Gaps = 50/353 (14%)
Query: 1033 PSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS 1092
P+D + S+ CS +C +GV S + Y+G ++D + P H
Sbjct: 271 PADMYRWKLSSHEPCSATCTTGVM--SAYAMCVRYDG----VEVDDSYCDALTRPEPVHE 324
Query: 1093 DCN----QYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDP 1148
C Q W T WS C T CGEG Q R VRC + + G V LC+
Sbjct: 325 FCAGRECQPRWETSSWSECSRT-------CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
Query: 1149 EEM--PLGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCP 1205
E P + C+ P C +SEW ++C C + S R IR DE P
Sbjct: 378 AEAVRPEERKTCRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLCDP 431
Query: 1206 NAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCE 1265
N N + V+DW C S CG G R + C SDG+ V C+
Sbjct: 432 NTRPVGEKNCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQ 487
Query: 1266 ALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPC 1325
K ++ CP + DW C+ TCG + +++R V +G+P
Sbjct: 488 ME--TKPLAIHPCGDKNCPAHWLAQDWE---RCNTTCG---RGVKKRLVLCMELANGKPQ 539
Query: 1326 ----PSLMDQSKP-----CPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISC 1369
P KP C +PC++W WS C CG G R R++ C
Sbjct: 540 TRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC 589
Score = 97.8 bits (242), Expect = 8e-20
Identities = 96/368 (26%), Positives = 148/368 (40%), Gaps = 58/368 (15%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLS-EWSNWSRCSKSCG 1052
C G C +G V+ S C++ E +C+ E S+WS CS++CG
Sbjct: 289 CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCG 348
Query: 1053 SGVKVRSK--WLREKP-YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKV 1109
G + R W P ++ + + E C + W WS C
Sbjct: 349 EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA 408
Query: 1110 TFVNMRENCGE-GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK-LPCPEDCV 1167
CGE V TR +RC + ++ LCDP P+G + C PC
Sbjct: 409 -------KCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEKNCTGPPCDRQWT 451
Query: 1168 ISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA---VEKEPCNLN----KNCY 1220
+S+WGP C+ S + R+ + +GR P + +E +P ++ KNC
Sbjct: 452 VSDWGP-------CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 504
Query: 1221 HYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
+ + DW C + CG G+K R++ C+ + GL K ++C
Sbjct: 505 AH-WLAQDWERCNTT----CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 559
Query: 1281 VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG--RPCPSLMD-------Q 1331
E P C SPWSEC++TCG+ +R R V + +QG R C L+
Sbjct: 560 -ERP--CFKWYTSPWSECTKTCGVG---VRMRDV-KCYQGTDIVRGCDPLVKPVGRQACD 612
Query: 1332 SKPCPVKP 1339
+PCP +P
Sbjct: 613 LQPCPTEP 620
Score = 76.6 bits (187), Expect = 2e-13
Identities = 85/365 (23%), Positives = 127/365 (34%), Gaps = 106/365 (29%)
Query: 427 WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQA-----NENLLSQLSTHK 481
W T+ W+EC + CG G Q R V C + + ++ S L +
Sbjct: 335 WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--E 376
Query: 482 NKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
EA +P + K C P C + E+S WS C + G++ R
Sbjct: 377 AAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTAKCGERSVVTR 418
Query: 542 KRRITNE---------PTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC 592
R + + P G TG PC+ W G C C
Sbjct: 419 DIRCSEDEKLCDPNTRPVGEKNCTGP--------PCDR----QWTVSDWGPCSGS----C 462
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTC 650
G G ++ V C SDG V C+ P+ + PC + W W C+ TC
Sbjct: 463 GQGRTIRHVYCKTSDGRVVPESQCQMETKPLAI---HPCGDKNCPAHWLAQDWERCNTTC 519
Query: 651 SGKTTEGKQIRARSILAYAGEEG------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPW 704
G+ ++ R +L G G C + E +C E PC + W T PW
Sbjct: 520 ------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPW 571
Query: 705 GQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC 764
+C + +C VG++ R V C + G + C ++P + C
Sbjct: 572 SECTK-----------------TCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQAC 611
Query: 765 -LLPC 768
L PC
Sbjct: 612 DLQPC 616
Score = 74.7 bits (182), Expect = 7e-13
Identities = 93/385 (24%), Positives = 131/385 (34%), Gaps = 124/385 (32%)
Query: 1238 AVCGNGIKTRMLDCVRSDGKSVDLKYCEAL-----------GLEKNWQMNTSCMVECPVN 1286
A C G+ + CVR DG VD YC+AL G E + TS EC
Sbjct: 287 ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRT 346
Query: 1287 C-------------QLS-----------------------------------DWSPWSEC 1298
C LS + S WSEC
Sbjct: 347 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 406
Query: 1299 SQTCGLTGKMIRRRTVTQPFQ--GDGRPCPSLMDQSKPCPVKPC------YRWQYGQWSP 1350
+ CG R VT+ + D + C ++P K C +W W P
Sbjct: 407 TAKCG------ERSVVTRDIRCSEDEKLCD---PNTRPVGEKNCTGPPCDRQWTVSDWGP 457
Query: 1351 CQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP 1410
C CG+G R++ C SDG +VV E C +E K + + +
Sbjct: 458 C---SGSCGQGRTIRHVYCKTSDG------RVVPESQC-QME-----TKPLAIHPCGDKN 502
Query: 1411 CPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELEN----QHLCPEQMLET 1466
CP +DW C TC G V+ R V+ EL N PE L
Sbjct: 503 CPAHWLAQDWER---CNTTCGRG---------VKKRLVLCMELANGKPQTRSGPECGLAK 550
Query: 1467 KSCYDGQCYE---YKWMASAWKGSSRT---------VWCQRSDGINVTGGCLVMSQPDAD 1514
K + C+E +KW S W ++T V C + G ++ GC + +P
Sbjct: 551 KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRGCDPLVKPVGR 608
Query: 1515 RSCN-PPC--SQPHSYCSETKTCHC 1536
++C+ PC P C + +C
Sbjct: 609 QACDLQPCPTEPPDDSCQDQPGTNC 633
Score = 71.2 bits (173), Expect = 8e-12
Identities = 86/386 (22%), Positives = 136/386 (35%), Gaps = 98/386 (25%)
Query: 120 ELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF-E 178
++Y W+L C + G+ C++ D + +D C+
Sbjct: 273 DMYRWKLSSHEPCSATCTT-------------GVMSAYAMCVRYD-GVEVDDSYCDALTR 318
Query: 179 PKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHV--VAPPQFGGSGCPNLT 236
P+P+ E CQ E S+WSECS+TCG G Q R + P F S +L
Sbjct: 319 PEPVHEFCAGRECQPRW---ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 375
Query: 237 EF---------QVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDR 287
E + C++ C + + WS C+ + R ++
Sbjct: 376 EAAEAVRPEERKTCRNPACGPQ-----WEMSEWSECT------AKCGERSVVTRDIRCSE 424
Query: 288 SKGVKDPEARELIKKKRNRNRQNRQENKYWDIQ----------IGYQTREVMCINKTGKA 337
+ + DP R + +K +RQ W + G R V C G+
Sbjct: 425 DEKLCDPNTRPVGEKNCTGPPCDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
Query: 338 ADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHDMVSPAGTRVRTRTIRQF 395
S CQ E P+ C K C + W +W C+ TC G V+ R +
Sbjct: 481 VPESQCQMETKPLAIHPCG-DKNCP-AHWLAQDWERCNTTC-------GRGVKKRLVLCM 531
Query: 396 PIGSEK-------EC---PEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQD 445
+ + K EC + E+ C + PC + W T+ W+EC
Sbjct: 532 ELANGKPQTRSGPECGLAKKPPEESTCFER-----PC--FKWYTSPWSEC---------- 574
Query: 446 KRRGNQTALCGGGIQTREVYCVQANE 471
T CG G++ R+V C Q +
Sbjct: 575 ------TKTCGVGVRMRDVKCYQGTD 594
Score = 63.5 bits (153), Expect = 2e-09
Identities = 99/376 (26%), Positives = 139/376 (36%), Gaps = 86/376 (22%)
Query: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPK 633
Y WK L + EP + C G +C+ DG EVD C P PV + +
Sbjct: 275 YRWK---LSSHEPCSAT-CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH-EFCAGR 329
Query: 634 DCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQ-EVR 687
+C W S+WS CS TC G+ + + +R +L+ G + + C + A++ E R
Sbjct: 330 EC-QPRWETSSWSECSRTC-GEGYQFRVVRCWKMLS-PGFDSSVYSDLCEAAEAVRPEER 386
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
+P W+ W +C T GE S + TR + C
Sbjct: 387 KTCRNPACGPQWEMSEWSEC------------TAKCGERS----VVTRDIRC------SE 424
Query: 748 GPKKCPESLRPETVRPCL-LPCKKDCIVTPYSDWTSCPSSCKEGDSSIR----KQSRHRV 802
K C + RP + C PC + V SDW C SC +G +IR K S RV
Sbjct: 425 DEKLCDPNTRPVGEKNCTGPPCDRQWTV---SDWGPCSGSCGQG-RTIRHVYCKTSDGRV 480
Query: 803 IIQLPANGGRDCTDPL----YEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQ 858
+ P + + T PL +K C A W W RC
Sbjct: 481 V---PESQCQMETKPLAIHPCGDKNCPA-------HWLAQDWERCNTT------------ 518
Query: 859 EGCGPGRQARAITCRKQDGGQAGIH---ECLQYAGPVPALTQACQIPCQDDCQLTSW--S 913
CG G + R + C + G+ EC A P + + PC W S
Sbjct: 519 --CGRGVKKRLVLCMELANGKPQTRSGPEC-GLAKKPPEESTCFERPC------FKWYTS 569
Query: 914 KFSSCNGDCG-AVRTR 928
+S C CG VR R
Sbjct: 570 PWSECTKTCGVGVRMR 585
Score = 52.8 bits (125), Expect = 3e-06
Identities = 97/419 (23%), Positives = 136/419 (32%), Gaps = 102/419 (24%)
Query: 643 WSSCSHT-CSGKTTEGKQIRARSILAYAGEE-GGIRCPNSSALQEVRS-CNEHPCTVYHW 699
W SH CS T G + Y G E C + + V C C W
Sbjct: 277 WKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP-RW 335
Query: 700 QTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNV----GQVGPKKCP-- 753
+T W +C +C G Q R V C ++ V C
Sbjct: 336 ETSSWSEC-----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 378
Query: 754 ESLRPETVRPCLLP-CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGR 812
E++RPE + C P C + S+W+ C + C E R V + +
Sbjct: 379 EAVRPEERKTCRNPACGPQWEM---SEWSECTAKCGE---------RSVVTRDIRCSEDE 426
Query: 813 DCTDPLYE---EKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
DP EK C P + +W W C CG GR R
Sbjct: 427 KLCDPNTRPVGEKNCTGPPCDR--QWTVSDWGPCS--------------GSCGQGRTIRH 470
Query: 870 ITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCGAVRT 927
+ C+ DG +C P+ PC D W + CN CG R
Sbjct: 471 VYCKTSDGRVVPESQCQMETKPLAIH------PCGDKNCPAHWLAQDWERCNTTCG--RG 522
Query: 928 RKRTLV-------GKSKKKE--KCKNSHLYPLIETQY-CPCDKYNAQPVGNWSDCILPEG 977
K+ LV GK + + +C + P T + PC K+ P WS+C
Sbjct: 523 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP---WSECT---- 575
Query: 978 KVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEAC-IIPCPSD 1035
K CG G R + + CY Q +V +AC + PCP++
Sbjct: 576 --------------KTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCPTE 619
Score = 50.4 bits (119), Expect = 1e-05
Identities = 61/294 (20%), Positives = 100/294 (34%), Gaps = 94/294 (31%)
Query: 992 KECGQGYRYQAMACYDQNG----RLVETSRCNSHGYI----EEACIIP-CPSDCKLSEW- 1041
+ CG+GY+++ + C+ V + C + + + C P C ++SEW
Sbjct: 345 RTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWS 404
Query: 1042 ------------------------------------------------SNWSRCSKSCGS 1053
S+W CS SCG
Sbjct: 405 ECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 464
Query: 1054 GVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVN 1113
G +R + + + GR P+ + + + PC W+ + W C T
Sbjct: 465 GRTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT--- 518
Query: 1114 MRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC-KLPCPEDCVISEW- 1171
CG GV+ R V CM+ A+G + C + P C + PC +W
Sbjct: 519 ----CGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWY 567
Query: 1172 -GPWTQCV-----------LPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPC 1213
PW++C + C Q + R DP+ +P GR A + +PC
Sbjct: 568 TSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV--GR---QACDLQPC 616
Score = 42.0 bits (97), Expect = 0.005
Identities = 34/135 (25%), Positives = 54/135 (40%), Gaps = 29/135 (21%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWC---AHVEGWTTLHTNCKQAERPNNQQNCFKVCDW 117
W W RC CG G ++ R V C A+ + T C A++P + CF+
Sbjct: 507 WLAQDWERC-NTTCGRG-VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFE---- 560
Query: 118 HKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF 177
+ + W PW++C G+++R++ C Q + D +
Sbjct: 561 -RPCFKWYTSPWSECTKTCG-------------VGVRMRDVKCYQGTDIVRGCDPLV--- 603
Query: 178 EPKPLLEQAC-LIPC 191
KP+ QAC L PC
Sbjct: 604 --KPVGRQACDLQPC 616
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 99.8 bits (247), Expect = 2e-20
Identities = 132/574 (22%), Positives = 206/574 (35%), Gaps = 160/574 (27%)
Query: 994 CGQGYRYQAMACYD-QNGRLVETSRCNSHGY-------IEEACIIPCPSDC--------- 1036
CG GY+ + CYD ++ R+V C+ + ++E + PCP+
Sbjct: 313 CGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYD 372
Query: 1037 ---KLSEW--SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV--- 1088
L W + W+ CS SCG G++ R+ E+ G HV + ++ +
Sbjct: 373 LYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQG--------HVTSVEEWKCMYTP 424
Query: 1089 --PCHSDCNQY---LWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVED 1143
P CN + W+ + WS C VT CG+G++ R V C+ D H
Sbjct: 425 KMPIAQPCNIFDCPKWLAQEWSPCTVT-------CGQGLRYRVVLCI----DHRGMHTGG 473
Query: 1144 YLCDPEEMPLGSRVCKLPCP------------------------EDCVISEWGP-----W 1174
C P+ P C +P P E +SE W
Sbjct: 474 --CSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAW 531
Query: 1175 TQCVLPCNQS------------SFRQRSAD-PIRQPADEGRSCPNAVEKEPCN------- 1214
+ C + C SF Q AD PI + + A PC+
Sbjct: 532 SACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFN 591
Query: 1215 ----------LNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKS-VDLKY 1263
L YD+ ++ C S CG G++ ++ C+ + +
Sbjct: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSES----CGGGVQEAVVSCLNKQTREPAEENL 647
Query: 1264 CEALGLEKNWQMNTSCMVE-CPVNCQLSDWSPWSECSQTCGL---TGKMIRRRTVTQPFQ 1319
C + + Q+ SC ++ CP ++ WSP CS TCG+ T + +++
Sbjct: 648 C--VTSRRPPQLLKSCNLDPCPARWEIGKWSP---CSLTCGVGLQTRDVFCSHLLSREMN 702
Query: 1320 GDGRPCPSLMDQSKPCPVKPCYR------WQYGQWSPCQVQEAQCGEGTRTRNISCVVSD 1373
L Q KP V+ C R W QW PC CG G + R + C
Sbjct: 703 ETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCS---RTCGGGVQKREVLC--KQ 757
Query: 1374 GSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP-CPGDCYLKDWSSWSLCQLTCVN 1432
AD + E FC+ +++C + CP + L DW+ C +C
Sbjct: 758 RMADGSFLELPETFCSA--------SKPACQQACKKDDCPSEWLLSDWTE---CSTSC-- 804
Query: 1433 GEDLGFGGIQVRS---RPVI---IQELENQHLCP 1460
GE G Q RS R ++ + + N LCP
Sbjct: 805 GE-----GTQTRSAICRKMLKTGLSTVVNSTLCP 833
Score = 91.7 bits (226), Expect = 5e-18
Identities = 149/612 (24%), Positives = 217/612 (35%), Gaps = 175/612 (28%)
Query: 838 HKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQY----AGPVP 893
H+WR P S CG G Q + C + + Y P P
Sbjct: 299 HRWRETDFFPCSAT---------CGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP 349
Query: 894 ALTQACQIPCQDDC------------QLTSW--SKFSSCNGDCGA-VRTRKRTLVGK--- 935
L + PC L W + +++C+ CG +++R + V +
Sbjct: 350 KLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQ 409
Query: 936 ----SKKKEKCKNSHLYPLIET-QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGD 990
S ++ KC + P+ + C K+ AQ WS C +
Sbjct: 410 GHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQ---EWSPCTVT--------------- 451
Query: 991 IKECGQGYRYQAMACYDQNGRLVETSRCN--SHGYIEEACIIPCPSDCKLSEWSNWSRCS 1048
CGQG RY+ + C D G + T C+ + +I+E CI+P P C
Sbjct: 452 ---CGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEECIVPTP-------------CY 493
Query: 1049 KSCGSGVKVRSKWLREK-PYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSIC 1107
K +EK P KL QAQ E S+ + ++ E WS C
Sbjct: 494 KP------------KEKLPVEA-----KLPWFKQAQELEEGAAVSE--EPSFIPEAWSAC 534
Query: 1108 KVTFVNMRENCGEGVQTRKVRCM------QNTADGPSEHVEDYLCDPEEMPLGSRVCKL- 1160
VT CG G Q R VRC Q+ AD P + E P R C
Sbjct: 535 TVT-------CGVGTQVRIVRCQVLLSFSQSVADLPIDECEG------PKPASQRACYAG 581
Query: 1161 PCPEDCVISEWGP-----------------------WTQCVLPCN---QSSFRQRSADPI 1194
PC + I E+ P +T+C C Q +
Sbjct: 582 PCSGE--IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQT 639
Query: 1195 RQPADEGRSCPNAVEKEPCNLNKNCYHYD-----YNVTDWSTCQLSEKAVCGNGIKTRML 1249
R+PA+E + P L K+C + D + + WS C L+ CG G++TR +
Sbjct: 640 REPAEENLC---VTSRRPPQLLKSC-NLDPCPARWEIGKWSPCSLT----CGVGLQTRDV 691
Query: 1250 DCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECP-VNCQLSDWSP--WSECSQTCGLTG 1306
C S S ++ L E Q S + C NC + W P W CS+TCG G
Sbjct: 692 FC--SHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPA-WYPAQWQPCSRTCG--G 746
Query: 1307 KMIRRRTVTQPFQGDGRPCP---SLMDQSKPCPVKPCYR------WQYGQWSPCQVQEAQ 1357
+ +R + + DG + SKP + C + W W+ C
Sbjct: 747 GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTS--- 803
Query: 1358 CGEGTRTRNISC 1369
CGEGT+TR+ C
Sbjct: 804 CGEGTQTRSAIC 815
Score = 91.3 bits (225), Expect = 7e-18
Identities = 138/602 (22%), Positives = 203/602 (33%), Gaps = 151/602 (25%)
Query: 646 CSHTCSG--KTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-------- 695
CS TC G + T + RS A + N +++ CN PC
Sbjct: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQI 368
Query: 696 ----VYH----WQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVN---- 743
+YH W+ PW C +SC G+Q+R V CV +
Sbjct: 369 MPYDLYHPLPRWEATPWTAC-----------------SSSCGGGIQSRAVSCVEEDIQGH 411
Query: 744 VGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVI 803
V V KC + + +PC + DC +W+ C +C +G R+RV+
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNI---FDCPKWLAQEWSPCTVTCGQG-------LRYRVV 461
Query: 804 IQLPANGGRD--C---TDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPW--SVQQDSPG 856
+ + G C T P +E+ C P C + K + +PW Q+ G
Sbjct: 462 LCIDHRGMHTGGCSPKTKPHIKEE-CIVPTPCYKPKEKLPVEAK---LPWFKQAQELEEG 517
Query: 857 AQEG----------------CGPGRQARAITCR-----KQDGGQAGIHECLQYAGPVPAL 895
A CG G Q R + C+ Q I EC GP PA
Sbjct: 518 AAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC---EGPKPAS 574
Query: 896 TQACQI-PC-------------------QDDCQLTSWSK--FSSCNGDCG-----AVRTR 928
+AC PC QD +L W F+ C+ CG AV +
Sbjct: 575 QRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC 634
Query: 929 KRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQ-PVGNWSDCILPEGKVEVLLGMKV 987
+ ++ C S P + + C D A+ +G WS C L
Sbjct: 635 LNKQTREPAEENLCVTSRRPPQL-LKSCNLDPCPARWEIGKWSPCSLT------------ 681
Query: 988 QGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSN---- 1043
CG G + + + C L+ + +E C P PS + N
Sbjct: 682 ------CGVGLQTRDVFC----SHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPA 731
Query: 1044 -----WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYL 1098
W CS++CG GV+ R +++ +G + ++ C D
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSE 791
Query: 1099 WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC 1158
W+ W+ C + CGEG QTR C + G S V LC P R C
Sbjct: 792 WLLSDWTECSTS-------CGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPC 844
Query: 1159 KL 1160
L
Sbjct: 845 ML 846
Score = 80.9 bits (198), Expect = 1e-14
Identities = 121/499 (24%), Positives = 171/499 (34%), Gaps = 113/499 (22%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAH---------VEGWTTLHTNCKQAERPNNQQNC 111
W+ PW C CG GGIQ+RAV C VE W ++T +P N +C
Sbjct: 380 WEATPWTAC-SSSCG-GGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDC 437
Query: 112 FKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAED 171
K W W+ C + L + G+ C K K E+
Sbjct: 438 PK----------WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTG--GCSPKTKPHIKEE 485
Query: 172 IICEY--FEPKPLLEQACLIP-------CQQDCIVSEF-----SAWSECSKTCGSGLQHR 217
I ++PK L +P ++ VSE AWS C+ TCG G Q R
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVR 545
Query: 218 TRHVVAPPQFGGSGC---------PNLTEFQVCQSSPCEAE------------------- 249
F S P + C + PC E
Sbjct: 546 IVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDF 605
Query: 250 ELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKG--VKDPEARELIKKKRNRN 307
+ Y ++ CS V++A NK+ + + V +L+K
Sbjct: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDP 665
Query: 308 RQNRQENKYWD-----IQIGYQTREVMC-------INKTGKAADLSFCQQEKLPMTFQSC 355
R E W +G QTR+V C +N+T AD C+Q K P T Q+C
Sbjct: 666 CPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILAD-ELCRQPK-PSTVQAC 723
Query: 356 VITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTI---RQFPIGSEKECPE--FEEKE 410
++W PCS+TC G V+ R + ++ GS E PE +
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTC-------GGGVQKREVLCKQRMADGSFLELPETFCSASK 776
Query: 411 PCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQAN 470
P Q C + W ++WTEC + CG G QTR C
Sbjct: 777 PACQQACKKDDCPS-EWLLSDWTEC----------------STSCGEGTQTRSAIC---R 816
Query: 471 ENLLSQLSTHKNKEASKPM 489
+ L + LST N P+
Sbjct: 817 KMLKTGLSTVVNSTLCPPL 835
Score = 68.9 bits (167), Expect = 4e-11
Identities = 63/227 (27%), Positives = 93/227 (40%), Gaps = 37/227 (16%)
Query: 1099 WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLC-DPEEMPLGSRV 1157
W+ WS C +CG GVQTR+V C + A G S V + +C + P+ ++
Sbjct: 1549 WMVTSWSACT-------RSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQA 1601
Query: 1158 CKLPCPEDCVISEWGPWT-QCVLPCNQSSFRQ---RSADPIRQPADEGRSCPNAVEKEPC 1213
C + S WG C+ P RQ ++ D I P+++ + P V + C
Sbjct: 1602 CNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNC 1661
Query: 1214 NLNKNCYHYDYNVTDWSTCQLSEKAVCGN-GIKTRMLDCVRS-DGKSVDLKYCEALGLEK 1271
H + V+ W+ C A CGN G ++R ++CV + K+V C
Sbjct: 1662 WSEACSVH--WRVSLWTLC----TATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPA 1715
Query: 1272 NWQM-------NTSC--------MVECPVNCQLSDWSPWSECSQTCG 1303
NWQ N C V+ CQLS + S C TCG
Sbjct: 1716 NWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFK--SRCCGTCG 1760
Score = 68.2 bits (165), Expect = 6e-11
Identities = 136/630 (21%), Positives = 208/630 (33%), Gaps = 183/630 (29%)
Query: 152 GIQVREIACIQKDKDIPAEDIICEYF----EPKPLLEQACLIPCQQDCIVS--------- 198
G Q+ C + D C Y+ +PKP L++ L PC
Sbjct: 316 GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYH 375
Query: 199 -----EFSAWSECSKTCGSGLQHRT---------RHVVAPPQFGGSGCPNLTEFQVCQSS 244
E + W+ CS +CG G+Q R HV + ++ P + Q C
Sbjct: 376 PLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIF 435
Query: 245 PCE---AEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIK 301
C A+E WS C++ + +R R + G P+ + IK
Sbjct: 436 DCPKWLAQE---------WSPCTVTCGQGLRY---RVVLCIDHRGMHTGGCSPKTKPHIK 483
Query: 302 KKRNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKEC 361
++ Y+ +E + + + KLP Q+ + +
Sbjct: 484 EECIVPTPC------------YKPKEKLPV-------------EAKLPWFKQAQELEEGA 518
Query: 362 QVSEWSE-----WSPCSKTCHDMVSPAGTRVR----------TRTIRQFPI--------G 398
VSE WS C+ TC GT+VR ++++ PI
Sbjct: 519 AVSEEPSFIPEAWSACTVTCG-----VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPA 573
Query: 399 SEKEC---------PEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRG 449
S++ C PEF E G Y W +T+C
Sbjct: 574 SQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKC-------------- 619
Query: 450 NQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLC--TGPIPNTTQLCHI 507
+ CGGG+Q V C+ NK+ +P + LC + P + C++
Sbjct: 620 --SESCGGGVQEAVVSCL--------------NKQTREPAEENLCVTSRRPPQLLKSCNL 663
Query: 508 -PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLL--- 563
PCP E+ WS PC+ C G L+ R + C HLL
Sbjct: 664 DPCPARWEIGKWS---PCSL-TC-------GVGLQTRDVF------------CSHLLSRE 700
Query: 564 --EAI-----PCEEPACYDWKAVRLGNCEP--------DNGKECGPGTQVQEVVCINSDG 608
E + C +P +A NC P + CG G Q +EV+C
Sbjct: 701 MNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMA 760
Query: 609 EEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTCSGKTTEGKQIRARSIL 666
+ +L AC C KD S W S W+ CS +C G+ T+ + R +L
Sbjct: 761 DGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSC-GEGTQTRSAICRKML 819
Query: 667 --AYAGEEGGIRCPNSSALQEVRSCNEHPC 694
+ CP +R C C
Sbjct: 820 KTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Score = 62.4 bits (150), Expect = 4e-09
Identities = 113/533 (21%), Positives = 179/533 (33%), Gaps = 134/533 (25%)
Query: 116 DWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKD---IPAEDI 172
D + L W PW C GIQ R ++C+++D E+
Sbjct: 372 DLYHPLPRWEATPWTACSSSCGG-------------GIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 173 ICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGC 232
C Y PK + Q C I DC WS C+ TCG GL++R + GC
Sbjct: 419 KCMY-TPKMPIAQPCNI---FDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 233 PNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVK 292
T+ P EE + P + C P + +A+ + +E + V
Sbjct: 475 SPKTK-------PHIKEEC-----IVP-TPCYKPKEKLPVEAKLPWFKQAQELEEGAAVS 521
Query: 293 D-----PEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC---INKTGKAADLSFCQ 344
+ PEA +G Q R V C ++ + ADL +
Sbjct: 522 EEPSFIPEAWSACTV---------------TCGVGTQVRIVRCQVLLSFSQSVADLPIDE 566
Query: 345 QEKLPMTFQSCVITKEC-----------------------QVSEW--SEWSPCSKTCHDM 379
E Q C ++ +W ++ CS++C
Sbjct: 567 CEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGG 626
Query: 380 VSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDP 439
V A + R+ +E+ + P L + + PC W +W+ C
Sbjct: 627 VQEAVVSCLNKQTRE---PAEENLCVTSRRPPQLLKSCNLDPCPA-RWEIGKWSPC---- 678
Query: 440 LLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIP 499
+ CG G+QTR+V+C S L + + E D +LC P P
Sbjct: 679 ------------SLTCGVGLQTRDVFC--------SHLLSREMNETVILAD-ELCRQPKP 717
Query: 500 NTTQLCH-IPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGN 558
+T Q C+ CP AW P ++ C+ G ++KR + + G
Sbjct: 718 STVQACNRFNCP--------PAWYPAQWQPCSRTCGG---GVQKREVLCKQRMADGSFLE 766
Query: 559 CPHLLEAIPCEEPACYDWKAVRLGNCE--------PDNGKECGPGTQVQEVVC 603
P +PAC +A + +C + CG GTQ + +C
Sbjct: 767 LPETF--CSASKPACQ--QACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 62.0 bits (149), Expect = 5e-09
Identities = 146/643 (22%), Positives = 233/643 (36%), Gaps = 155/643 (24%)
Query: 363 VSEWSE--WSPCSKTC---HDMVSPAGTRVRTRTI------RQFPIGSEKECPEFEE--K 409
+ W E + PCS TC + + S +R+ + +P + K P+ +E
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP-ENIKPKPKLQECNL 356
Query: 410 EPCLSQGDG---VVPCATYG----WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTR 462
+PC + DG ++P Y W T WT C ++ CGGGIQ+R
Sbjct: 357 DPCPAS-DGYKQIMPYDLYHPLPRWEATPWTAC----------------SSSCGGGIQSR 399
Query: 463 EVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSA- 520
V CV+ E++ +++ + + K P Q C+I CP W A
Sbjct: 400 AVSCVE--EDIQGHVTSVE--------EWKCMYTPKMPIAQPCNIFDCP------KWLAQ 443
Query: 521 -WGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNC-----PHLLEAIPCEEPACY 574
W PCT C G LR R + G TG C PH+ E P CY
Sbjct: 444 EWSPCTV-TC-------GQGLRYRVVLCIDHRGMH-TGGCSPKTKPHIKEECIVPTP-CY 493
Query: 575 DWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKD 634
K + K Q QE+ +G V + + P
Sbjct: 494 KPKEKLPVEAKLPWFK------QAQEL----EEGAAVSEE---PSFIP------------ 528
Query: 635 CVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQEVRSCNE 691
WS+C+ TC G T+ + +R + +L+++ + C + R+C
Sbjct: 529 ------EAWSACTVTC-GVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQ-RACYA 580
Query: 692 HPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEA------SCSVGMQTRKVICVRVNVG 745
PC+ + P + F+ W E SC G+Q V C+
Sbjct: 581 GPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTR 640
Query: 746 QVGPKK-CPESLR-PETVRPCLL-PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRV 802
+ + C S R P+ ++ C L PC + W+ C +C G + H
Sbjct: 641 EPAEENLCVTSRRPPQLLKSCNLDPCPARWEI---GKWSPCSLTCGVGLQTRDVFCSH-- 695
Query: 803 IIQLPANGGRDCTDPLYEEKACEAPQACQSYR----WKTHKWRRCQLVPWSVQQDSPGAQ 858
++ N D L + QAC + W +W+ C
Sbjct: 696 LLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPC--------------S 741
Query: 859 EGCGPGRQARAITCRKQ--DGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SK 914
CG G Q R + C+++ DG + E A PA QAC+ +DDC + W S
Sbjct: 742 RTCGGGVQKREVLCKQRMADGSFLELPETFCSASK-PACQQACK---KDDCP-SEWLLSD 796
Query: 915 FSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCP 957
++ C+ CG T+ R+ + + K + L ++ + CP
Sbjct: 797 WTECSTSCGE-GTQTRSAICR-----KMLKTGLSTVVNSTLCP 833
Score = 57.8 bits (138), Expect = 9e-08
Identities = 45/171 (26%), Positives = 65/171 (38%), Gaps = 40/171 (23%)
Query: 61 WKTGPWGRCMGDECGPG-GIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCF-KVCDWH 118
W WG+C G GP +Q R V+C +G T C RP + QNC+ + C H
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVH 1669
Query: 119 KELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFE 178
WR+ W C G G Q R + C+ + + +C +
Sbjct: 1670 -----WRVSLWTLCTATC------------GNYGFQSRRVECVHARTNKAVPEHLCSW-G 1711
Query: 179 PKPLLEQAC-LIPCQ-----------------QDCIVSEFSAWSECSKTCG 211
P+P Q C + PC+ + C +S+F S C TCG
Sbjct: 1712 PRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFK--SRCCGTCG 1760
Score = 56.2 bits (134), Expect = 3e-07
Identities = 55/219 (25%), Positives = 88/219 (40%), Gaps = 37/219 (16%)
Query: 58 LYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTN-CKQAERPNNQQNCFKVCD 116
LY W+ + +C + CG GG+Q V C + + N C + RP K C+
Sbjct: 608 LYDWEYEGFTKC-SESCG-GGVQEAVVSCLNKQTREPAEENLCVTSRRP---PQLLKSCN 662
Query: 117 WHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACI-----QKDKDIPAED 171
W +G W+ C L C G+Q R++ C + ++ + D
Sbjct: 663 LDPCPARWEIGKWSPCS----------LTC---GVGLQTRDVFCSHLLSREMNETVILAD 709
Query: 172 IICEYFEPKPLLEQACLIPCQQDCIVSEFSA-WSECSKTCGSGLQHRTRHVVAPPQFGGS 230
+C +PKP QAC + +C + + A W CS+TCG G+Q R V+ +
Sbjct: 710 ELCR--QPKPSTVQACN---RFNCPPAWYPAQWQPCSRTCGGGVQ--KREVLCKQRMADG 762
Query: 231 GCPNLTEFQVCQSSP-----CEAEELRYSLHVGPWSTCS 264
L E S P C+ ++ + W+ CS
Sbjct: 763 SFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECS 801
Score = 53.5 bits (127), Expect = 2e-06
Identities = 60/233 (25%), Positives = 92/233 (39%), Gaps = 51/233 (21%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHV------EGWTTLHTNCKQAERPNNQQNCFKV 114
W+ G W C CG G +QTR V+C+H+ E C+Q +P+ Q C +
Sbjct: 670 WEIGKWSPC-SLTCGVG-LQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRF 726
Query: 115 CDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKD---IPAED 171
C P + +P G G+Q RE+ C Q+ D + +
Sbjct: 727 ----------------NCPPAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPE 769
Query: 172 IICEYFEPKPLLEQACLIPCQQDCIVSEF--SAWSECSKTCGSGLQHRTRHVVAPPQFGG 229
C +P AC C++D SE+ S W+ECS +CG G Q TR +
Sbjct: 770 TFCSASKP------ACQQACKKDDCPSEWLLSDWTECSTSCGEGTQ--TRSAICRKML-K 820
Query: 230 SGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMP------HSRQVRQARR 276
+G + +C P + S+ +TC+ P HS + AR+
Sbjct: 821 TGLSTVVNSTLCPPLPFSS-----SIRPCMLATCARPGRPSTKHSPHIAAARK 868
Score = 51.2 bits (121), Expect = 8e-06
Identities = 57/262 (21%), Positives = 90/262 (34%), Gaps = 39/262 (14%)
Query: 521 WGPCTYENCNDQQGKKGFKLRKRR--ITNEPTGGSGVTGNCPHLLEAIPCEEPACYD-WK 577
W C+ G +G + + R + + + G ++ I C C W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 578 AVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPI---PVACDAPCPKD 634
C + CG G Q + V C + + D + PV A +
Sbjct: 1551 VTSWSACT----RSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 635 CVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNS--SALQ---EVRSC 689
CV +S+W C+ C G + + + GI P+ SAL ++C
Sbjct: 1607 CVEWAFSSWGQCNGPCI-----GPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNC 1661
Query: 690 NEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGP 749
C+V HW+ W C T T N G Q+R+V CV + P
Sbjct: 1662 WSEACSV-HWRVSLWTLC----------TATCGN------YGFQSRRVECVHARTNKAVP 1704
Query: 750 KK-CPESLRPETVRPC-LLPCK 769
+ C RP + C + PC+
Sbjct: 1705 EHLCSWGPRPANWQRCNITPCE 1726
Score = 51.2 bits (121), Expect = 8e-06
Identities = 50/200 (25%), Positives = 74/200 (37%), Gaps = 36/200 (18%)
Query: 1298 CSQTCGLTG------KMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC-YRWQYGQWSP 1350
CS +CG G + + T P G+ P++ Q C + C RW WS
Sbjct: 1499 CSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAV--QPIACNRRDCPSRWMVTSWSA 1556
Query: 1351 CQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP 1410
C CG G +TR ++C A S V + C + K V ++C+Q
Sbjct: 1557 CT---RSCGGGVQTRRVTC--QKLKASGISTPVSNDMCTQVA------KRPVDTQACNQQ 1605
Query: 1411 CPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQM------L 1464
C +SSW C C+ + V+ R V Q + L EQ +
Sbjct: 1606 L---CVEWAFSSWGQCNGPCIGPH------LAVQHRQVFCQTRDGITLPSEQCSALPRPV 1656
Query: 1465 ETKSCYDGQCYEYKWMASAW 1484
T++C+ C W S W
Sbjct: 1657 STQNCWSEAC-SVHWRVSLW 1675
Score = 49.3 bits (116), Expect = 3e-05
Identities = 69/304 (22%), Positives = 108/304 (35%), Gaps = 64/304 (21%)
Query: 644 SSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNS--SALQEVRSCNEHPCTVYHWQT 701
++CS +C + + ++R L + E C A+Q + +CN C W
Sbjct: 1497 ATCSASCGNRGVQQPRLRC---LLNSTEVNPAHCAGKVRPAVQPI-ACNRRDCPS-RWMV 1551
Query: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETV 761
W C SC G+QTR+V C ++ + +
Sbjct: 1552 TSWSACTR-----------------SCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAK 1594
Query: 762 RPC-LLPCKKD-CIVTPYSDWTSCPSSCKEGDSSIRKQS---RHRVIIQLPANGGRDCTD 816
RP C + C+ +S W C C +++ + + R I LP+
Sbjct: 1595 RPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPR 1654
Query: 817 PLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGP-GRQARAITCRKQ 875
P+ + +AC S W+ W C CG G Q+R + C
Sbjct: 1655 PVSTQNCWS--EAC-SVHWRVSLWTLCTAT--------------CGNYGFQSRRVECVHA 1697
Query: 876 DGGQAGIHECLQYAGPVPALTQACQI-PCQD-DC-------------QLTSWSKFSS-CN 919
+A + E L GP PA Q C I PC++ +C +L S+F S C
Sbjct: 1698 RTNKA-VPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFKSRCC 1756
Query: 920 GDCG 923
G CG
Sbjct: 1757 GTCG 1760
Score = 47.4 bits (111), Expect = 1e-04
Identities = 42/169 (24%), Positives = 67/169 (39%), Gaps = 33/169 (19%)
Query: 1227 TDWSTCQLSEKAVCGNGIKTRMLDC--VRSDGKSVDLKYCEAL--GLEKNWQMNTSCMVE 1282
TD+ C A CG G + +C +RS+ D +YC ++ ++ +
Sbjct: 304 TDFFPCS----ATCGGGYQLTSAECYDLRSNRVVAD-QYCHYYPENIKPKPKLQECNLDP 358
Query: 1283 CPVNC------------QLSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSL 1328
CP + L W +PW+ CS +CG + V + QG
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 1329 -------MDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCV 1370
M ++PC + C +W +WSPC V CG+G R R + C+
Sbjct: 419 KCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTV---TCGQGLRYRVVLCI 464
Score = 46.6 bits (109), Expect = 2e-04
Identities = 55/252 (21%), Positives = 90/252 (35%), Gaps = 46/252 (18%)
Query: 1222 YDYNVTDWSTCQLSEKAVCGN-GIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSC- 1279
Y ++V +TC S CGN G++ L C+ + S ++ G + +C
Sbjct: 1489 YWWSVDRLATCSAS----CGNRGVQQPRLRCLLN---STEVNPAHCAGKVRPAVQPIACN 1541
Query: 1280 MVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQ-------- 1331
+CP ++ WS C+++CG G + RR Q + G P D
Sbjct: 1542 RRDCPSRWMVTSWSA---CTRSCG--GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP 1596
Query: 1332 --SKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCA 1389
++ C + C W + W C + R + C DG + E C+
Sbjct: 1597 VDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGIT------LPSEQCS 1650
Query: 1390 DIELIIDGNKNMVLEESCSQPCPGDCYLKDW--SSWSLCQLTCVNGEDLGFGGIQVRSRP 1447
+ + +Q C + W S W+LC TC N GF +V
Sbjct: 1651 ALPRPVS-----------TQNCWSEACSVHWRVSLWTLCTATCGN---YGFQSRRVECVH 1696
Query: 1448 VIIQELENQHLC 1459
+ +HLC
Sbjct: 1697 ARTNKAVPEHLC 1708
Score = 46.6 bits (109), Expect = 2e-04
Identities = 55/230 (23%), Positives = 77/230 (33%), Gaps = 39/230 (16%)
Query: 59 YLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWH 118
Y W C CG G+Q + C + +C RP Q C+
Sbjct: 1489 YWWSVDRLATCSAS-CGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIA---CNRR 1543
Query: 119 KELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDK----DIPAEDIIC 174
W + W+ C G+Q R + C QK K P + +C
Sbjct: 1544 DCPSRWMVTSWSACTRSCGG-------------GVQTRRVTC-QKLKASGISTPVSNDMC 1589
Query: 175 EYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTC---GSGLQHR-----TRHVVAPPQ 226
+P+ QAC QQ C+ FS+W +C+ C +QHR TR + P
Sbjct: 1590 TQVAKRPVDTQACN---QQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPS 1646
Query: 227 FGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARR 276
S P Q C S C V W+ C+ Q+RR
Sbjct: 1647 EQCSALPRPVSTQNCWSEACSVH-----WRVSLWTLCTATCGNYGFQSRR 1691
Score = 45.8 bits (107), Expect = 3e-04
Identities = 59/225 (26%), Positives = 81/225 (36%), Gaps = 41/225 (18%)
Query: 1035 DCKLSEW--SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS 1092
DC S W ++WS C++SCG GV+ R ++ +G D Q V
Sbjct: 1544 DCP-SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDT--Q 1600
Query: 1093 DCNQYL---WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADG---PSEHVEDYLC 1146
CNQ L W W C + VQ R+V C T DG PSE C
Sbjct: 1601 ACNQQLCVEWAFSSWGQCNGPCIGPH----LAVQHRQVFC--QTRDGITLPSEQ-----C 1649
Query: 1147 DPEEMPLGSRVCKLPCPEDCVISEW--GPWTQCVLPCNQSSFRQRSADPIRQPADEG--- 1201
P+ ++ C E C + W WT C C F+ R + + ++
Sbjct: 1650 SALPRPVSTQNC---WSEACSV-HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPE 1705
Query: 1202 RSC---PNAVEKEPCNL----NKNC---YHYDYNVTDWSTCQLSE 1236
C P + CN+ N C Y V CQLS+
Sbjct: 1706 HLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQ 1750
Score = 45.4 bits (106), Expect = 4e-04
Identities = 58/204 (28%), Positives = 77/204 (37%), Gaps = 49/204 (24%)
Query: 322 GYQTREVMC--INKTGKAADLS--FCQQ-EKLPMTFQSCVITKECQVSEWSEWSPCSKTC 376
G QTR V C + +G + +S C Q K P+ Q+C + C +S W C+ C
Sbjct: 1564 GVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACN-QQLCVEWAFSSWGQCNGPC 1622
Query: 377 ---HDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWT 433
H V +TR P P + C S+ C+ + WR + WT
Sbjct: 1623 IGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA-----CSVH-WRVSLWT 1676
Query: 434 ECRVDPLLSQQDKRRGNQTALCGG-GIQTREVYCVQANENLLSQLSTHKNKEASKPMDLK 492
C TA CG G Q+R V CV A N K +
Sbjct: 1677 LC----------------TATCGNYGFQSRRVECVHARTN--------------KAVPEH 1706
Query: 493 LCT-GPIPNTTQLCHI-PCPT-EC 513
LC+ GP P Q C+I PC EC
Sbjct: 1707 LCSWGPRPANWQRCNITPCENMEC 1730
Score = 42.7 bits (99), Expect = 0.003
Identities = 62/278 (22%), Positives = 106/278 (38%), Gaps = 42/278 (15%)
Query: 1097 YLWVTEPWSICKVTFVNMRENCGE-GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGS 1155
Y W + + C + CG GVQ ++RC+ N+ + H + P P+
Sbjct: 1489 YWWSVDRLATCSAS-------CGNRGVQQPRLRCLLNSTEVNPAHCAGKV-RPAVQPIAC 1540
Query: 1156 RVCKLPCPEDCVISEWGPWTQCV---LPCNQSSFRQRSADPIRQPADEGRSCPNA---VE 1209
+ CP +++ W T+ + + + ++ A I P A V+
Sbjct: 1541 N--RRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVD 1598
Query: 1210 KEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGN---GIKTRMLDCVRSDGKSVDLKYCEA 1266
+ CN + C + ++ W C C ++ R + C DG ++ + C A
Sbjct: 1599 TQACN-QQLCVEWAFS--SWGQCN----GPCIGPHLAVQHRQVFCQTRDGITLPSEQCSA 1651
Query: 1267 LGLEKNWQMNTSCMVE-CPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPC 1325
L + Q +C E C V+ ++S W+ C+ TCG G RR V +
Sbjct: 1652 LPRPVSTQ---NCWSEACSVHWRVS---LWTLCTATCGNYGFQSRR--VECVHARTNKAV 1703
Query: 1326 PSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTR 1363
P + P P WQ +PC+ E C + TR
Sbjct: 1704 PEHLCSWGPRPA----NWQRCNITPCENME--CRDTTR 1735
Score = 38.9 bits (89), Expect = 0.042
Identities = 22/84 (26%), Positives = 32/84 (38%), Gaps = 19/84 (22%)
Query: 633 KDCVLSTWSTWSSCSHTCSG------------KTTEGKQIRARSILAYAGEEGGIRCPNS 680
+D + W WS CS TC G K+ EG+ IR R+ + CP
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTC-------SNVDCPPE 84
Query: 681 SALQEVRSCNEHPCTVYHWQTGPW 704
+ + C+ H +H Q W
Sbjct: 85 AGDFRAQQCSAHNDVKHHGQFYEW 108
Score = 37.4 bits (85), Expect = 0.12
Identities = 49/223 (21%), Positives = 77/223 (34%), Gaps = 62/223 (27%)
Query: 201 SAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVC---QSSPCEAEELRYSLHV 257
++WS C+++CG G+Q R V + SG +C P + + L V
Sbjct: 1552 TSWSACTRSCGGGVQTRR---VTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 258 ----GPWSTCSMP--------HSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRN 305
W C+ P RQV R G E + L +
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSE----------QCSALPRPVST 1658
Query: 306 RNRQNRQENKYWDIQI-----------GYQTREVMCIN-KTGKAADLSFCQQEKLPMTFQ 353
+N + + +W + + G+Q+R V C++ +T KA C P +Q
Sbjct: 1659 QNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQ 1718
Query: 354 SCVIT--------------------KECQVSEWSEWSPCSKTC 376
C IT K CQ+S++ S C TC
Sbjct: 1719 RCNITPCENMECRDTTRYCEKVKQLKLCQLSQFK--SRCCGTC 1759
Score = 37.0 bits (84), Expect = 0.16
Identities = 29/101 (28%), Positives = 35/101 (34%), Gaps = 30/101 (29%)
Query: 427 WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEAS 486
W T W+ C T CGGG+QTR V C + K S
Sbjct: 1549 WMVTSWSAC----------------TRSCGGGVQTRRVTCQKL-----------KASGIS 1581
Query: 487 KPMDLKLCT--GPIPNTTQLCHIPCPTECEVSPWSAW-GPC 524
P+ +CT P TQ C+ E S W GPC
Sbjct: 1582 TPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPC 1622
Score = 33.1 bits (74), Expect = 2.3
Identities = 15/57 (26%), Positives = 25/57 (43%), Gaps = 4/57 (7%)
Query: 193 QDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAE 249
+D + + WSECS+TCG G + R ++ G ++ C + C E
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRN----IRYRTCSNVDCPPE 84
Score = 32.3 bits (72), Expect = 3.9
Identities = 10/12 (83%), Positives = 11/12 (91%)
Query: 1292 WSPWSECSQTCG 1303
W PWSECS+TCG
Sbjct: 39 WGPWSECSRTCG 50
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 97.1 bits (240), Expect = 1e-19
Identities = 105/414 (25%), Positives = 156/414 (37%), Gaps = 83/414 (20%)
Query: 1029 IIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREK-PYNGGRPCPKLDHVNQAQVYEV 1087
I C + + W++WS CS +CG G +VR + P +GGR C V Q +
Sbjct: 589 IANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVC-----VGQNREERY 643
Query: 1088 VPCHSDCNQYLWVTE--PWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYL 1145
H C +++ T PW C CG G+Q R+ C +N D +VE
Sbjct: 644 CNEHLLCPPHMFWTGWGPWERCTA-------QCGGGIQARRRIC-ENGPDCAGCNVEYQS 695
Query: 1146 CDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRS--------ADP---- 1193
C+ PCPE + W PWT + N + QR ADP
Sbjct: 696 CNTN-----------PCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLE 744
Query: 1194 -------IRQPADEGRS--CPNAVEKEPCNLNKNCYHYDYNV----TDWSTCQLSEKAVC 1240
+R + +G S + + + + H T WS C C
Sbjct: 745 VGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRD----C 800
Query: 1241 GNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQ 1300
GI+ R C + + KY L + + ++ CPV+ S WSPW++CS
Sbjct: 801 SRGIRNRKRVC-----NNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSA 855
Query: 1301 TCGLTGKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPC-YRW-QYGQWSPC-----Q 1352
TCG G +R R+ + P G C L + C +PC W ++ WS C Q
Sbjct: 856 TCG-GGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEASGVQ 914
Query: 1353 VQEAQC---------GEGTRTRNISCVVSDGSADDF----SKVVDEEFCADIEL 1393
V+ QC G T + CV + S V+E+ C + +
Sbjct: 915 VRARQCILLFPMGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNM 968
Score = 75.1 bits (183), Expect = 5e-13
Identities = 96/406 (23%), Positives = 148/406 (36%), Gaps = 85/406 (20%)
Query: 603 CINSDGEEVDRQLCRDAIFPIPVA------CDAP------CPKDCVLSTWSTWSSCSHTC 650
C ++DG V LCR P C+ P C ++ + W++WS CS TC
Sbjct: 552 CTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTC 611
Query: 651 SGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEH---PCTVYHWQTGPWGQC 707
G Q+R RS GG C + +E R CNEH P ++ GPW +C
Sbjct: 612 G----IGFQVRQRSCSNPTPRHGGRVCVGQN--REERYCNEHLLCPPHMFWTGWGPWERC 665
Query: 708 IEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLP 767
A C G+Q R+ IC + GP ++ ++ P
Sbjct: 666 -----------------TAQCGGGIQARRRIC------ENGPDCAGCNVEYQSCN--TNP 700
Query: 768 CKKDCIVTPYSDWTSCPSS-------------CKE--GDSSIRKQSRHRVIIQLPANGGR 812
C + TP++ WT S CK D ++ + R R+ ++ ++ G
Sbjct: 701 CPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGT 760
Query: 813 D--CTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI 870
TD L + ++ R+ H WS C G + R
Sbjct: 761 SGCSTDGL-------SGDFLRAGRYSAHTVNGA----WSAWTSWSQCSRDCSRGIRNRKR 809
Query: 871 TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGA---VRT 927
C + G+ CL GP + +PC D + WS ++ C+ CG +RT
Sbjct: 810 VCNNPEPKYGGM-PCL---GPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRT 865
Query: 928 RKRTLVGKSKKKEKCKNSHL-YPLIETQYCPCDKYNAQPVGNWSDC 972
R + + + C H L TQ CP + +WS+C
Sbjct: 866 RSCSNPAPAYGGDICLGLHTEEALCNTQPCP---ESWSEWSDWSEC 908
Score = 73.9 bits (180), Expect = 1e-12
Identities = 89/364 (24%), Positives = 144/364 (39%), Gaps = 55/364 (15%)
Query: 768 CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAP 827
C ++ TP++ W+ C ++C G +R++S P +GGR C EE+ C
Sbjct: 592 CSRNGGWTPWTSWSPCSTTCGIG-FQVRQRSCSN---PTPRHGGRVCVGQNREERYCNEH 647
Query: 828 QACQSYRWKTH--KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQ-AGIHE 884
C + + T W RC AQ CG G QAR C ++G AG +
Sbjct: 648 LLCPPHMFWTGWGPWERCT------------AQ--CGGGIQARRRIC--ENGPDCAGCN- 690
Query: 885 CLQYAGPVPALTQACQI-PCQDDCQLTSWSKFSSCN-GDCGAVRTRKRTLVGKSKKKEKC 942
++Y Q+C PC + + T W+ ++ N D G ++ K++ +
Sbjct: 691 -VEY--------QSCNTNPCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPN 741
Query: 943 KNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGKVEVLLGMKVQGD----------IK 992
IE +YC D + S L G+ V G +
Sbjct: 742 LLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSA---HTVNGAWSAWTSWSQCSR 798
Query: 993 ECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCG 1052
+C +G R + C + + +E I+PCP D S WS W++CS +CG
Sbjct: 799 DCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCG 858
Query: 1053 SGVKVRSK-WLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTF 1111
G +R++ P GG C L H +A + PC +++ WS C+ +
Sbjct: 859 GGHYMRTRSCSNPAPAYGGDICLGL-HTEEA-LCNTQPCPESWSEW----SDWSECEASG 912
Query: 1112 VNMR 1115
V +R
Sbjct: 913 VQVR 916
Score = 65.9 bits (159), Expect = 3e-10
Identities = 97/422 (22%), Positives = 138/422 (32%), Gaps = 75/422 (17%)
Query: 334 TGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIR 393
T LS Q E+ + +T + WS W+PC+ T V R R+
Sbjct: 514 TSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCD-- 571
Query: 394 QFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRT--TEWTECRVDPLLSQQDKRR--G 449
+C ++ C G + C+ G T T W+ C + Q ++R
Sbjct: 572 ----SPAPQCGGWQ----CEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCS 623
Query: 450 NQTALCGG----GIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLC 505
N T GG G E YC NE+LL C G I ++C
Sbjct: 624 NPTPRHGGRVCVGQNREERYC---NEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRIC 680
Query: 506 H-----------------IPCPTECEVSPWSAWGPCTYENCNDQQG--KKGF-------- 538
PCP + +PW+ W P N +D G ++ F
Sbjct: 681 ENGPDCAGCNVEYQSCNTNPCPELKKTTPWTPWTPV---NISDNGGHYEQRFRYTCKARL 737
Query: 539 -----------KLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYD-WKA-VRLGNCE 585
++ R +++ T G G L A W A C
Sbjct: 738 ADPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQC- 796
Query: 586 PDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSS 645
++C G + ++ VC N+ + C PCP D V S WS W+
Sbjct: 797 ---SRDCSRGIRNRKRVC-NNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTK 852
Query: 646 CSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWG 705
CS TC G G +R RS A GG C E CN PC + W
Sbjct: 853 CSATCGG----GHYMRTRSCSNPAPAYGGDICLGLHT--EEALCNTQPCPESWSEWSDWS 906
Query: 706 QC 707
+C
Sbjct: 907 EC 908
Score = 65.1 bits (157), Expect = 5e-10
Identities = 115/456 (25%), Positives = 161/456 (35%), Gaps = 118/456 (25%)
Query: 640 WSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHW 699
WS W+ C+HT G R RS + A + GG +C E+ +C+ + W
Sbjct: 546 WSPWTPCTHT-DGSAVGSCLCRTRSCDSPAPQCGGWQCEGPG--MEIANCSRNG----GW 598
Query: 700 QTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPE 759
PW TS S +TT C +G Q R+ C + G + C R E
Sbjct: 599 T--PW------TSWSPCSTT--------CGIGFQVRQRSCSN-PTPRHGGRVCVGQNREE 641
Query: 760 TVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLY 819
L C T + W C + C G Q+R R+ G DC
Sbjct: 642 RYCNEHLLCPPHMFWTGWGPWERCTAQCGGG-----IQARRRI-----CENGPDCAGCNV 691
Query: 820 EEKACEAPQACQSYRWKTHKWRRCQLVPWSVQ--QDSPGAQEG---------------CG 862
E ++C C + KT W PW+ D+ G E
Sbjct: 692 EYQSCNT-NPCPELK-KTTPW-----TPWTPVNISDNGGHYEQRFRYTCKARLADPNLLE 744
Query: 863 PGRQARAITCRKQDGGQA----GIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSC 918
GRQ + DG G+ AG A T + ++W+ +S C
Sbjct: 745 VGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTV--------NGAWSAWTSWSQC 796
Query: 919 NGDCG-AVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYC---PCDKYNAQPV-GNWSDCI 973
+ DC +R RKR V + + + L P +E Q C PC PV G WS C
Sbjct: 797 SRDCSRGIRNRKR--VCNNPEPKYGGMPCLGPSLEYQECNILPC------PVDGVWS-CW 847
Query: 974 LPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQN---------GRLVETSRCNSHGYI 1024
P K CG G+ + +C + G E + CN+
Sbjct: 848 SPWTKCSA-----------TCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQ--- 893
Query: 1025 EEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSK 1060
PCP SEWS+WS C SGV+VR++
Sbjct: 894 ------PCPE--SWSEWSDWSECE---ASGVQVRAR 918
Score = 60.5 bits (145), Expect = 1e-08
Identities = 79/353 (22%), Positives = 121/353 (34%), Gaps = 66/353 (18%)
Query: 516 SPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEE----P 571
+PW++W PC+ C GF++R+R +N PT G E C E P
Sbjct: 599 TPWTSWSPCS-TTCGI-----GFQVRQRSCSN-PTPRHGGRVCVGQNREERYCNEHLLCP 651
Query: 572 ACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSD---GEEVDRQLCRDAIFPIPVACD 628
W G E +CG G Q + +C N G V+ Q C
Sbjct: 652 PHMFWTG--WGPWERCTA-QCGGGIQARRRICENGPDCAGCNVEYQSCNTN--------- 699
Query: 629 APCPKDCVLSTWSTWSSCS-------------HTCSGKTTEGKQI---RARSILAYAGEE 672
PCP+ + W+ W+ + +TC + + + R R + Y +
Sbjct: 700 -PCPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSD 758
Query: 673 GGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNG-EASCSVG 731
G C + + H G W + T+W+ CS G
Sbjct: 759 GTSGCSTDGLSGDFLRAGRYSA---HTVNGAW------------SAWTSWSQCSRDCSRG 803
Query: 732 MQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGD 791
++ RK +C G SL + +LPC D + + +S WT C ++C G
Sbjct: 804 IRNRKRVCNNPEPKYGGMPCLGPSLEYQECN--ILPCPVDGVWSCWSPWTKCSATCGGGH 861
Query: 792 SSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQ 844
+ + PA GG C EE C Q C + W C+
Sbjct: 862 YMRTRSCSN----PAPAYGGDICLGLHTEEALCNT-QPCPESWSEWSDWSECE 909
Score = 56.2 bits (134), Expect = 3e-07
Identities = 39/103 (37%), Positives = 50/103 (48%), Gaps = 16/103 (15%)
Query: 173 ICEYFEPK--------PLLE-QAC-LIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVV 222
+C EPK P LE Q C ++PC D + S +S W++CS TCG G RTR
Sbjct: 810 VCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCS 869
Query: 223 AP-PQFGGSGCPNL-TEFQVCQSSPCEAEELRYSLHVGPWSTC 263
P P +GG C L TE +C + PC +S WS C
Sbjct: 870 NPAPAYGGDICLGLHTEEALCNTQPCPESWSEWS----DWSEC 908
Score = 54.3 bits (129), Expect = 1e-06
Identities = 66/264 (25%), Positives = 99/264 (37%), Gaps = 48/264 (18%)
Query: 1225 NVTDW----STCQLSEKAVCGN-GIKTRMLDCVRSDGKSVDLKYCEALGLEK------NW 1273
++T W S C V G+ G+ + C +DG +V C + W
Sbjct: 521 SMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGW 580
Query: 1274 QMNTSCM--VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPF-QGDGRPCPSLMD 1330
Q M C N + W+ WS CS TCG+ G +R+R+ + P + GR C
Sbjct: 581 QCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGI-GFQVRQRSCSNPTPRHGGRVCVGQNR 639
Query: 1331 QSKPCP---VKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEF 1387
+ + C + P + + G W P + AQCG G + R C + D
Sbjct: 640 EERYCNEHLLCPPHMFWTG-WGPWERCTAQCGGGIQARRRIC---ENGPD---------- 685
Query: 1388 CADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRP 1447
CA N+ + + PCP W+ W T VN D G G + R R
Sbjct: 686 CAGC--------NVEYQSCNTNPCPELKKTTPWTPW-----TPVNISDNG-GHYEQRFRY 731
Query: 1448 VIIQELENQHLCP--EQMLETKSC 1469
L + +L Q +E + C
Sbjct: 732 TCKARLADPNLLEVGRQRIEMRYC 755
Score = 50.1 bits (118), Expect = 2e-05
Identities = 56/220 (25%), Positives = 84/220 (38%), Gaps = 70/220 (31%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGC--PNLTEFQVCQSSPCEAEELRYS 254
S +++WS+CS+ C G+++R R P P++GG C P+L E+Q C PC + +
Sbjct: 788 SAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSL-EYQECNILPCPVDGVWSC 846
Query: 255 LHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQEN 314
PW+ CS A G + R R+ N
Sbjct: 847 W--SPWTKCS---------ATCGGGH---------------------YMRTRSCSNPAPA 874
Query: 315 KYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSK 374
DI +G T E + C + P ++ SEWS+WS C
Sbjct: 875 YGGDICLGLHTEEAL-------------CNTQPCPESW-----------SEWSDWSEC-- 908
Query: 375 TCHDMVSPAGTRVRTR-TIRQFPIGSEKECPEFEEKEPCL 413
+G +VR R I FP+GS+ E PC+
Sbjct: 909 ------EASGVQVRARQCILLFPMGSQCS-GNTTESRPCV 941
Score = 48.1 bits (113), Expect = 7e-05
Identities = 122/529 (23%), Positives = 172/529 (32%), Gaps = 144/529 (27%)
Query: 91 GWTTLHTNCKQAERPNNQ---QNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECI 147
GW + C E + + C D G W+ P
Sbjct: 505 GWDVVMKKCTSLEESLSMTQWEQSISACPTRNLTVDGHFGVWSPWTPCTHT--------- 555
Query: 148 KGEEGIQVREIACIQKDKDIPAEDIICEYFEPK-PLLEQACLIPCQQDCIVSEFSAWSEC 206
+G V C + D PA C ++ + P +E A C ++ + +++WS C
Sbjct: 556 ---DGSAVGSCLCRTRSCDSPAPQ--CGGWQCEGPGMEIA---NCSRNGGWTPWTSWSPC 607
Query: 207 SKTCGSGLQHRTRHVVAP-PQFGGSGCPNLT-EFQVCQSSPCEAEELRYSLHV-----GP 259
S TCG G Q R R P P+ GG C E + C E L H+ GP
Sbjct: 608 STTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCN------EHLLCPPHMFWTGWGP 661
Query: 260 WSTCSMPHSRQVRQARRR---------GKNKEREKDRSKGVKDPEARELIK-------KK 303
W C+ + QARRR G N E + + PE ++
Sbjct: 662 WERCTAQCGGGI-QARRRICENGPDCAGCNVEYQSCNTNPC--PELKKTTPWTPWTPVNI 718
Query: 304 RNRNRQNRQENKYWD---------IQIGYQTREVMCINKTGKAADLSFCQQEKLPMTF-- 352
+ Q +Y +++G Q E+ + G S C + L F
Sbjct: 719 SDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDG----TSGCSTDGLSGDFLR 774
Query: 353 --QSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEK- 409
+ T S W+ WS CS+ C G R R R C E K
Sbjct: 775 AGRYSAHTVNGAWSAWTSWSQCSRDC-----SRGIRNRKRV-----------CNNPEPKY 818
Query: 410 --EPCLS-----QGDGVVPCATYG-WRT-TEWTECRVDPLLSQQDKRRGNQTALCGGGIQ 460
PCL Q ++PC G W + WT+C +A CGGG
Sbjct: 819 GGMPCLGPSLEYQECNILPCPVDGVWSCWSPWTKC----------------SATCGGGHY 862
Query: 461 TREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWS 519
R C N + D +C G + LC+ PCP S WS
Sbjct: 863 MRTRSC--------------SNPAPAYGGD--ICLG-LHTEEALCNTQPCPESW--SEWS 903
Query: 520 AWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPC 568
W C G ++R R+ GS +GN E+ PC
Sbjct: 904 DWSECE---------ASGVQVRARQCILLFPMGSQCSGN---TTESRPC 940
Score = 32.3 bits (72), Expect = 3.9
Identities = 41/176 (23%), Positives = 57/176 (32%), Gaps = 46/176 (26%)
Query: 430 TEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPM 489
T W++C D C GI+ R+ C + + K P
Sbjct: 791 TSWSQCSRD----------------CSRGIRNRKRVC-----------NNPEPKYGGMP- 822
Query: 490 DLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEP 549
C GP + +PCP + S WS W C+ C G +R R +N
Sbjct: 823 ----CLGPSLEYQECNILPCPVDGVWSCWSPWTKCS-ATCGG-----GHYMRTRSCSNPA 872
Query: 550 TGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC-GPGTQVQEVVCI 604
G H EA+ +P W E + EC G QV+ CI
Sbjct: 873 PAYGGDICLGLHTEEALCNTQPCPESWS-------EWSDWSECEASGVQVRARQCI 921
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 96.7 bits (239), Expect = 2e-19
Identities = 140/607 (23%), Positives = 203/607 (33%), Gaps = 166/607 (27%)
Query: 833 YRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITC----RKQDGGQAGIHECLQY 888
Y+ +H+WR+ P +V CG G Q + C K+ H +
Sbjct: 336 YQPISHQWRQTDFFPCTVT---------CGGGYQLNSAECVDIRLKRVVPDHYCHYYPEN 386
Query: 889 AGPVPALTQACQIPCQ-----------DDCQ-LTSW--SKFSSCNGDCGA-VRTRKRTLV 933
P P L + PC D Q L W + +++C+ CG ++ R V
Sbjct: 387 VKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCV 446
Query: 934 GKSKKKE-------KCKNSHLYPLIET-QYCPCDKYNAQPVGNWSDCILPEGKVEVLLGM 985
+S E KC + +++T C K+ A WS C +
Sbjct: 447 EESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAM---EWSQCTVT---------- 493
Query: 986 KVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWS 1045
CG+G RY+ + C + G V +I+E C+IP P
Sbjct: 494 --------CGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIP------------ 533
Query: 1046 RCSK-SCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPW 1104
C K S V+ + WL+ Q E+ + ++ EPW
Sbjct: 534 -CYKPKEKSPVEAKLPWLK-------------------QAQELEETRIATEEPTFIPEPW 573
Query: 1105 SICKVTFVNMRENCGEGVQTRKVRC------MQNTADGPSEHVEDYLCDPEEMPL----- 1153
S C T CG GVQ R+V+C Q + P E E P E P
Sbjct: 574 SACSTT-------CGPGVQVREVKCRVLLTFTQTETELPEEECEGPKL-PTERPCLLEAC 625
Query: 1154 ----GSRVCKLPCPEDCVIS---EWGPWTQCVLPC---------------NQSSFRQRSA 1191
SR +P PED + E+ +T C C Q +
Sbjct: 626 DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
Query: 1192 DPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDC 1251
D + +P ++C EPC ++V W C A CG GI+TR + C
Sbjct: 686 DMVHRPPAMSQAC----NTEPCPPR-------WHVGSWGPC----SATCGVGIQTRDVYC 730
Query: 1252 VRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRR 1311
+ + C EK + +CP + + W +CS+TCG G R
Sbjct: 731 LHPGETPAPPEECRD---EKPHALQACNQFDCPPGWHIEE---WQQCSRTCG--GGTQNR 782
Query: 1312 RTVTQPFQGDG---RPCPSLMDQSKPCPVKPCYRWQ------YGQWSPCQVQEAQCGEGT 1362
R + DG L K K C R G WS C V CG G
Sbjct: 783 RVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSV---SCGVGI 839
Query: 1363 RTRNISC 1369
+ R C
Sbjct: 840 QRRKQVC 846
Score = 85.5 bits (210), Expect = 4e-16
Identities = 118/538 (21%), Positives = 194/538 (36%), Gaps = 113/538 (21%)
Query: 677 CPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRK 736
CP+S +E+ +H + W+ PW C SC G+Q R
Sbjct: 401 CPSSDGFKEIMPY-DHFQPLPRWEHNPWTAC-----------------SVSCGGGIQRRS 442
Query: 737 VICVRVNVG----QVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDS 792
+CV ++ QV KC + +P+ ++ C L DC +W+ C +C G
Sbjct: 443 FVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNL---FDCPKWIAMEWSQCTVTCGRG-- 497
Query: 793 SIRKQSRHRVIIQLPANG----GRDCTDPLYEEKACEAPQACQSYRWKT----------- 837
R+RV++ + G G + L+ ++ C P C + K+
Sbjct: 498 -----LRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQ 552
Query: 838 ----HKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCR-----KQDGGQAGIHECLQY 888
+ R P + + CGPG Q R + CR Q + EC
Sbjct: 553 AQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGP 612
Query: 889 AGPV--PALTQACQ---------IPCQDDCQLT---SWSKFSSCNGDCGAVRTRKRTLVG 934
P P L +AC IP +D + T ++ F+ C C ++ V
Sbjct: 613 KLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGH-QEAIAVC 671
Query: 935 KSKKKEKCKNSHLYPLIETQYCPCDKYNAQP------VGNWSDCILPEGKVEVLLGMKVQ 988
+ ++ N L ++ N +P VG+W C
Sbjct: 672 LHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT------------- 718
Query: 989 GDIKECGQGYRYQAMACYDQNGRLVETSRCNSHG-YIEEACI-IPCPSDCKLSEWSNWSR 1046
CG G + + + C C + +AC CP + EW +
Sbjct: 719 -----CGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQ---Q 770
Query: 1047 CSKSCGSGVKVRSKWLREKPYNGG--RPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPW 1104
CS++CG G + R R+ +G +L +A ++ +DC +L V + W
Sbjct: 771 CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSC-ARTDCPPHLAVGD-W 828
Query: 1105 SICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLC-DPEEMPLGSRVCKLP 1161
S C V+ CG G+Q RK C + A G + + +C D +PL R C++P
Sbjct: 829 SKCSVS-------CGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPL-VRSCQMP 878
Score = 81.6 bits (200), Expect = 6e-15
Identities = 144/618 (23%), Positives = 208/618 (33%), Gaps = 167/618 (27%)
Query: 367 SEWSPCSKTC---HDMVSPAGTRVRTRTI------RQFPIGSEKECPEFEE--KEPCLSQ 415
+++ PC+ TC + + S +R + + +P + K P+ +E +PC S
Sbjct: 346 TDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYP-ENVKPKPKLKECSMDPCPSS 404
Query: 416 GDGVVPCATYG-------WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQ 468
DG Y W WT C V CGGGIQ R CV+
Sbjct: 405 -DGFKEIMPYDHFQPLPRWEHNPWTACSVS----------------CGGGIQRRSFVCVE 447
Query: 469 ANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSA--WGPCT 525
+ + E + + K P P Q C++ CP W A W CT
Sbjct: 448 ES----------MHGEILQVEEWKCMYAPKPKVMQTCNLFDCPK------WIAMEWSQCT 491
Query: 526 YENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHL--------LEAIPCEEP------ 571
C G LR R + G V G P L + IPC +P
Sbjct: 492 V-TC-------GRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPV 543
Query: 572 -ACYDW-------KAVRLGNCEPDNGKE--------CGPGTQVQEVVC-----INSDGEE 610
A W + R+ EP E CGPG QV+EV C E
Sbjct: 544 EAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETE 603
Query: 611 VDRQLCRDAIFPIPVAC--------------DAPCPKDCVLSTWSTWSSCSHTCSGKTTE 656
+ + C P C D P P+D T W T T
Sbjct: 604 LPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDS--ETTYDWEYAGFTPCTATCV 661
Query: 657 GKQIRARSILAYAGEEGGIRCPNSSALQEV-------RSCNEHPCTVYHWQTGPWGQCIE 709
G A ++ + + + N S V ++CN PC W G WG C
Sbjct: 662 GGHQEAIAVCLHIQTQQTV---NDSLCDMVHRPPAMSQACNTEPCPP-RWHVGSWGPC-- 715
Query: 710 DTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC-LLPC 768
A+C VG+QTR V C+ P++C + +P ++ C C
Sbjct: 716 ---------------SATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDC 759
Query: 769 KKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGG-RDCTDPLYEEKACEAP 827
+ +W C +C G Q+R QL +G + +D L C+ P
Sbjct: 760 PPGWHI---EEWQQCSRTCGGG-----TQNRRVTCRQLLTDGSFLNLSDEL-----CQGP 806
Query: 828 QACQSYRWKTHK-WRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRK--QDGGQAGIHE 884
+A +HK R P D CG G Q R C++ G + + E
Sbjct: 807 KA------SSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSE 860
Query: 885 CLQYAGPVPALTQACQIP 902
+ P L ++CQ+P
Sbjct: 861 MMCRDLPGLPLVRSCQMP 878
Score = 80.5 bits (197), Expect = 1e-14
Identities = 70/257 (27%), Positives = 107/257 (41%), Gaps = 39/257 (15%)
Query: 1040 EWSNWSRCSKSCGS-GVKVRSKWLREKPY----NGGRPCPKL-DHVNQAQVYEVVPCHSD 1093
E NWS CS +CG G ++ ++P NG L DH+ Q + PC+
Sbjct: 1429 EPGNWSHCSATCGHLGARI------QRPQCVMANGQEVSEALCDHL-QKPLAGFEPCNIR 1481
Query: 1094 CNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPL 1153
W T WS C V+ CGEG +R+V C + A+G + V C P++ PL
Sbjct: 1482 DCPARWFTSVWSQCSVS-------CGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPL 1534
Query: 1154 GSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPC 1213
G + C CV +W P +C C + R + Q +C + K P
Sbjct: 1535 GRKPC---FGHPCV--QWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDD--RKRP- 1586
Query: 1214 NLNKNC----YHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDG-KSVDLKYCEALG 1268
L +NC ++ W C A CG G ++R +DC+ + K V ++C
Sbjct: 1587 TLRRNCTSGACDVCWHTGPWKPC----TAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKK 1642
Query: 1269 LEKNWQ--MNTSCMVEC 1283
+W+ + SC +C
Sbjct: 1643 KPISWRHCLGPSCDRDC 1659
Score = 79.3 bits (194), Expect = 3e-14
Identities = 119/493 (24%), Positives = 177/493 (35%), Gaps = 122/493 (24%)
Query: 994 CGQGYRYQAMACYD-QNGRLVETSRCNSHGY-------IEEACIIPCPSDCKLSE----- 1040
CG GY+ + C D + R+V C+ + ++E + PCPS E
Sbjct: 355 CGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYD 414
Query: 1041 -------WSN--WSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQ-VYEVVP- 1089
W + W+ CS SCG G++ RS E+ +G ++ V + + +Y P
Sbjct: 415 HFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHG-----EILQVEEWKCMYAPKPK 469
Query: 1090 CHSDCNQY---LWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLC 1146
CN + W+ WS C VT CG G++ R V C+ + EHV C
Sbjct: 470 VMQTCNLFDCPKWIAMEWSQCTVT-------CGRGLRYRVVLCINHRG----EHVGG--C 516
Query: 1147 DPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPN 1206
+P+ KL E+CVI C P +S + P + A E
Sbjct: 517 NPQ--------LKLHIKEECVIP-----IPCYKPKEKSPVEAKL--PWLKQAQELEETRI 561
Query: 1207 AVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDC-----VRSDGKSVDL 1261
A E EP + + WS C + CG G++ R + C +
Sbjct: 562 ATE-EPTFIPE----------PWSACSTT----CGPGVQVREVKCRVLLTFTQTETELPE 606
Query: 1262 KYCEALGLEKNWQMNTSCMVECPVNCQLS-----------DW--SPWSECSQTCGLTGKM 1308
+ CE L E P + +L DW + ++ C+ TC G
Sbjct: 607 EECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC--VGGH 664
Query: 1309 IRRRTVTQPFQGDGRPCPSLMDQ-------SKPCPVKPCY-RWQYGQWSPCQVQEAQCGE 1360
V Q SL D S+ C +PC RW G W PC A CG
Sbjct: 665 QEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCS---ATCGV 721
Query: 1361 GTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDW 1420
G +TR++ C+ + E C D K L+ CP ++++W
Sbjct: 722 GIQTRDVYCLHPGETP------APPEECRD-------EKPHALQACNQFDCPPGWHIEEW 768
Query: 1421 SSWSLCQLTCVNG 1433
C TC G
Sbjct: 769 QQ---CSRTCGGG 778
Score = 66.6 bits (161), Expect = 2e-10
Identities = 130/569 (22%), Positives = 195/569 (34%), Gaps = 151/569 (26%)
Query: 116 DWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKD---IPAEDI 172
D + L W PW C + GIQ R C+++ + E+
Sbjct: 414 DHFQPLPRWEHNPWTACS-------------VSCGGGIQRRSFVCVEESMHGEILQVEEW 460
Query: 173 ICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGC 232
C Y PKP + Q C + DC WS+C+ TCG GL++R VV C
Sbjct: 461 KCMY-APKPKVMQTCNL---FDCPKWIAMEWSQCTVTCGRGLRYR---VVL--------C 505
Query: 233 PNLTEFQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVK 292
N V +P + LH+ +P K KE+ +K
Sbjct: 506 INHRGEHVGGCNP------QLKLHIKEECVIPIPCY----------KPKEKSPVEAKLPW 549
Query: 293 DPEARELIKKKRNRNRQNRQENKYWDIQI-----GYQTREVMC-----INKTGKAADLSF 342
+A+EL ++ R + + W G Q REV C +T
Sbjct: 550 LKQAQEL-EETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEE 608
Query: 343 CQQEKLPMTFQSCVITKECQVS--------------------EWSEWSPCSKTC---HDM 379
C+ KLP T + C++ + C S E++ ++PC+ TC H
Sbjct: 609 CEGPKLP-TERPCLL-EACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQE 666
Query: 380 VSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDP 439
++T+ ++ C + + P +SQ PC W W C
Sbjct: 667 AIAVCLHIQTQQTV-----NDSLC-DMVHRPPAMSQACNTEPCPPR-WHVGSWGPC---- 715
Query: 440 LLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIP 499
+A CG GIQTR+VYC+ E P + C P
Sbjct: 716 ------------SATCGVGIQTRDVYCLHPGET---------------PAPPEECRDEKP 748
Query: 500 NTTQLCH-IPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGN 558
+ Q C+ CP + W C+ C G + RR+T G N
Sbjct: 749 HALQACNQFDCPPGWHIEEWQ---QCS-RTC-------GGGTQNRRVTCRQLLTDGSFLN 797
Query: 559 CPHLLEAIPCEEPACYDWKAVRLGNCEP-----DNGK---ECGPGTQVQEVVC--INSDG 608
L C+ P K+ +C P D K CG G Q ++ VC + + G
Sbjct: 798 LSDEL----CQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKG 853
Query: 609 EEV--DRQLCRDAI-FPIPVACDAP-CPK 633
+ +CRD P+ +C P C K
Sbjct: 854 RRIPLSEMMCRDLPGLPLVRSCQMPECSK 882
Score = 65.5 bits (158), Expect = 4e-10
Identities = 136/604 (22%), Positives = 199/604 (32%), Gaps = 140/604 (23%)
Query: 152 GIQVREIACIQKDKDIPAEDIICEYF----EPKPLLEQACLIPCQ--------------Q 193
G Q+ C+ D C Y+ +PKP L++ + PC Q
Sbjct: 358 GYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQ 417
Query: 194 DCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGG---------SGCPNLTEFQVCQSS 244
E + W+ CS +CG G+Q R+ V G P Q C
Sbjct: 418 PLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLF 477
Query: 245 PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKR 304
C WS C++ R +R N E G +P+ + IK++
Sbjct: 478 DCP------KWIAMEWSQCTVTCGRGLRYRVVLCINHRGE---HVGGCNPQLKLHIKEE- 527
Query: 305 NRNRQNRQENKYWDIQIG-YQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQV 363
I I Y+ +E K+ A L + +Q + + I E
Sbjct: 528 ------------CVIPIPCYKPKE-----KSPVEAKLPWLKQAQ---ELEETRIATEEPT 567
Query: 364 SEWSEWSPCSKTCHDMVSPAGTRVR-----TRTIRQFPIGSEKEC--PEFEEKEPCLSQG 416
WS CS TC V + R T+T + P E+EC P+ + PCL +
Sbjct: 568 FIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELP---EEECEGPKLPTERPCLLEA 624
Query: 417 DGVVPCA-------------TYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTRE 463
P + TY W +T C TA C GG Q
Sbjct: 625 CDESPASRELDIPLPEDSETTYDWEYAGFTPC----------------TATCVGGHQEAI 668
Query: 464 VYC--VQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSA 520
C +Q + + L ++ P +Q C+ PCP V +
Sbjct: 669 AVCLHIQTQQTVNDSLCDMVHRP--------------PAMSQACNTEPCPPRWHV---GS 711
Query: 521 WGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPAC-YDWKAV 579
WGPC+ Q + + L P PH L+A C + C W
Sbjct: 712 WGPCSATCGVGIQTRDVYCLHP---GETPAPPEECRDEKPHALQA--CNQFDCPPGWHIE 766
Query: 580 RLGNCEPDNGKECGPGTQVQEVVC--INSDGE--EVDRQLCRDAIFPIPVAC-DAPCPKD 634
C + CG GTQ + V C + +DG + +LC+ +C CP
Sbjct: 767 EWQQC----SRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPH 822
Query: 635 CVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEE---GGIRCPNSSALQEVRSCNE 691
+ WS CS +C KQ+ R LA G + C + L VRSC
Sbjct: 823 LAV---GDWSKCSVSCGVGIQRRKQVCQR--LAAKGRRIPLSEMMCRDLPGLPLVRSCQM 877
Query: 692 HPCT 695
C+
Sbjct: 878 PECS 881
Score = 57.4 bits (137), Expect = 1e-07
Identities = 57/220 (25%), Positives = 83/220 (37%), Gaps = 35/220 (15%)
Query: 54 EAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTN-CKQAERPNNQQNCF 112
++ T Y W+ + C C GG Q C H++ T++ + C RP
Sbjct: 641 DSETTYDWEYAGFTPCTAT-C-VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMS--- 695
Query: 113 KVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDI 172
+ C+ W +G W C GIQ R++ C+ + PA
Sbjct: 696 QACNTEPCPPRWHVGSWGPCSATCGV-------------GIQTRDVYCLHPG-ETPAPPE 741
Query: 173 ICEYFEPKPLLEQACLIPCQQDCIVS-EFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSG 231
C + KP QAC Q DC W +CS+TCG G Q+ R V
Sbjct: 742 ECR--DEKPHALQACN---QFDCPPGWHIEEWQQCSRTCGGGTQN--RRVTCRQLLTDGS 794
Query: 232 CPNLTEFQVCQS------SPCEAEELRYSLHVGPWSTCSM 265
NL++ ++CQ C + L VG WS CS+
Sbjct: 795 FLNLSD-ELCQGPKASSHKSCARTDCPPHLAVGDWSKCSV 833
Score = 57.0 bits (136), Expect = 1e-07
Identities = 63/258 (24%), Positives = 89/258 (34%), Gaps = 87/258 (33%)
Query: 585 EPDNGKECGP-----GTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCP-KDCVLS 638
EP N C G ++Q C+ ++G+EV LC P+A PC +DC +
Sbjct: 1429 EPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDH--LQKPLAGFEPCNIRDCP-A 1485
Query: 639 TW--STWSSCSHTCSGKTTEGKQIRARSILAYAGE------------------------- 671
W S WS CS +C G+ +Q+ + A
Sbjct: 1486 RWFTSVWSQCSVSC-GEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 672 ---EGGIRCPNSSALQEV---------------------------RSCNEHPCTVYHWQT 701
E G RCP + V R+C C V W T
Sbjct: 1545 VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVC-WHT 1603
Query: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRV-NVGQVGPKKCPESLRPET 760
GPW C A+C G Q+RKV C+ + V + C + +P +
Sbjct: 1604 GPWKPC-----------------TAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPIS 1646
Query: 761 VRPCLLP-CKKDCIVTPY 777
R CL P C +DC T +
Sbjct: 1647 WRHCLGPSCDRDCTDTTH 1664
Score = 56.2 bits (134), Expect = 3e-07
Identities = 69/270 (25%), Positives = 102/270 (37%), Gaps = 56/270 (20%)
Query: 1292 WSP--WSECSQTCGLTGKMIRRRTVTQPFQGDGRP-----CPSL---MDQSKPCPVKPC- 1340
W P WS CS TCG G I+R Q +G+ C L + +PC ++ C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQR---PQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP 1484
Query: 1341 YRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKN 1400
RW WS C V CGEG +R ++C A+ +VV CA + + G K
Sbjct: 1485 ARWFTSVWSQCSV---SCGEGYHSRQVTC--KRTKANGTVQVVSPRACAPKDRPL-GRK- 1537
Query: 1401 MVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCP 1460
PC G ++ W + C C+ ++++ R Q + C
Sbjct: 1538 ---------PCFGHPCVQ-WEPGNRCPGRCMG------RAVRMQQRHTACQHNSSDSNCD 1581
Query: 1461 EQMLET--KSCYDGQCYEYKWMASAWKG---------SSRTVWC--QRSDGINVTGGCLV 1507
++ T ++C G C + W WK SR V C RS C+
Sbjct: 1582 DRKRPTLRRNCTSGAC-DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQ 1640
Query: 1508 MSQPDADR-----SCNPPCSQPHSYCSETK 1532
+P + R SC+ C+ YC K
Sbjct: 1641 KKKPISWRHCLGPSCDRDCTDTTHYCMFVK 1670
Score = 54.7 bits (130), Expect = 7e-07
Identities = 110/471 (23%), Positives = 159/471 (33%), Gaps = 111/471 (23%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCA----HVEGWTTLHTNCKQAERPNNQQNCFKVCD 116
W+ PW C CG GGIQ R+ C H E C A +P Q C
Sbjct: 422 WEHNPWTAC-SVSCG-GGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTC----- 474
Query: 117 WHKELYD---WRLGPWNQCQPVISKSLE-KPLECI--KGEE--------GIQVRE----- 157
L+D W W+QC + L + + CI +GE + ++E
Sbjct: 475 ---NLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIP 531
Query: 158 IACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHR 217
I C + + P E + + + L E I ++ + E WS CS TCG G+Q R
Sbjct: 532 IPCYKPKEKSPVEAKLPWLKQAQELEETR--IATEEPTFIPE--PWSACSTTCGPGVQVR 587
Query: 218 ----------TRHVVAPPQFGGSGCPNLTE----FQVCQSSPCEAE-------------E 250
T+ P+ G TE + C SP E +
Sbjct: 588 EVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYD 647
Query: 251 LRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQN 310
Y+ +TC H + + V P A + +
Sbjct: 648 WEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPA--MSQACNTEPCPP 705
Query: 311 RQENKYW-----DIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSE 365
R W +G QTR+V C++ A C+ EK P Q+C +C
Sbjct: 706 RWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK-PHALQAC-NQFDCPPG- 762
Query: 366 W--SEWSPCSKTCHDMVSPAGTRVRTRTIRQ------FPIGSEKEC--PEFEEKEPCLSQ 415
W EW CS+TC GT+ R T RQ F S++ C P+ + C
Sbjct: 763 WHIEEWQQCSRTC-----GGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCAR- 816
Query: 416 GDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYC 466
C + +W++C V CG GIQ R+ C
Sbjct: 817 ----TDCPPH-LAVGDWSKCSVS----------------CGVGIQRRKQVC 846
Score = 53.9 bits (128), Expect = 1e-06
Identities = 53/182 (29%), Positives = 69/182 (37%), Gaps = 34/182 (18%)
Query: 41 RPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCK 100
RP A A E P W G WG C CG G IQTR V+C H C+
Sbjct: 690 RPPAMSQACNTEPCPPR---WHVGSWGPCSAT-CGVG-IQTRDVYCLHPGETPAPPEECR 744
Query: 101 QAERPNNQQNCFKV-CDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIA 159
E+P+ Q C + C W + W QC G Q R +
Sbjct: 745 D-EKPHALQACNQFDCP-----PGWHIEEWQQCSRTCGG-------------GTQNRRVT 785
Query: 160 CIQKDKD---IPAEDIICEYFEPKPLLEQACL-IPCQQDCIVSEFSAWSECSKTCGSGLQ 215
C Q D + D +C+ PK ++C C V + WS+CS +CG G+Q
Sbjct: 786 CRQLLTDGSFLNLSDELCQ--GPKASSHKSCARTDCPPHLAVGD---WSKCSVSCGVGIQ 840
Query: 216 HR 217
R
Sbjct: 841 RR 842
Score = 43.5 bits (101), Expect = 0.002
Identities = 45/211 (21%), Positives = 70/211 (33%), Gaps = 35/211 (16%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE 120
W+ G W C CG G + + C G C ++P F+ C+
Sbjct: 1428 WEPGNWSHCSAT-CGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAG---FEPCNIRDC 1483
Query: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
W W+QC + EG R++ C + + + + PK
Sbjct: 1484 PARWFTSVWSQCS-------------VSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPK 1530
Query: 181 --PLLEQACL-IPCQQDCIVSEFSAWSECSKTC-GSGLQHRTRHVVAPPQFGGSGCPNL- 235
PL + C PC Q + + C C G ++ + RH S C +
Sbjct: 1531 DRPLGRKPCFGHPCVQ------WEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRK 1584
Query: 236 --TEFQVCQSSPCEAEELRYSLHVGPWSTCS 264
T + C S C+ H GPW C+
Sbjct: 1585 RPTLRRNCTSGACDV-----CWHTGPWKPCT 1610
Score = 40.4 bits (93), Expect = 0.014
Identities = 39/157 (24%), Positives = 54/157 (34%), Gaps = 23/157 (14%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKE 120
W T W +C CG G +R V C + T+ +A P ++ K C H
Sbjct: 1487 WFTSVWSQC-SVSCGEG-YHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHP- 1543
Query: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
W P N+C P C+ +Q R AC D +D +
Sbjct: 1544 CVQWE--PGNRC----------PGRCMGRAVRMQQRHTACQHNSSDSNCDD------RKR 1585
Query: 181 PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHR 217
P L + C C + W C+ CG G Q R
Sbjct: 1586 PTLRRNCTSGACDVCWHT--GPWKPCTAACGRGFQSR 1620
Score = 37.7 bits (86), Expect = 0.093
Identities = 43/193 (22%), Positives = 65/193 (33%), Gaps = 37/193 (19%)
Query: 322 GYQTREVMC----INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCH 377
GY +R+V C N T + C + P+ K C +W P ++ C
Sbjct: 1502 GYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG------RKPCFGHPCVQWEPGNR-CP 1554
Query: 378 DMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRV 437
R++ R S+ C + K P L + C W T W C
Sbjct: 1555 GRCMGRAVRMQQRHTACQHNSSDSNCDD--RKRPTLRRNCTSGACDVC-WHTGPWKPC-- 1609
Query: 438 DPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGP 497
TA CG G Q+R+V C+ ++ + KP+ + C GP
Sbjct: 1610 --------------TAACGRGFQSRKVDCIHTRS--CKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 498 -----IPNTTQLC 505
+TT C
Sbjct: 1654 SCDRDCTDTTHYC 1666
Score = 33.5 bits (75), Expect = 1.8
Identities = 67/292 (22%), Positives = 97/292 (33%), Gaps = 74/292 (25%)
Query: 365 EWSEWSPCSKTCHDMVSPAGTRVRTR--TIRQFPIGSEKECPEFEEK----EPCLSQGDG 418
E WS CS TC + G R++ + SE C ++ EPC
Sbjct: 1429 EPGNWSHCSATCGHL----GARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC-----N 1479
Query: 419 VVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANEN-LLSQL 477
+ C W T+ W++C V CG G +R+V C + N + +
Sbjct: 1480 IRDCPAR-WFTSVWSQCSVS----------------CGEGYHSRQVTCKRTKANGTVQVV 1522
Query: 478 STHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTEC---EVSPWSAWGPCTY----ENCN 530
S +P+ K C G P CP C V C + NC+
Sbjct: 1523 SPRACAPKDRPLGRKPCFGH-PCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCD 1581
Query: 531 DQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGK 590
D ++R T SG C H PC
Sbjct: 1582 D----------RKRPTLRRNCTSGACDVCWHTGPWKPCT--------------------A 1611
Query: 591 ECGPGTQVQEVVCINSDG-EEVDRQLCRDAIFPIPVA-CDAP-CPKDCVLST 639
CG G Q ++V CI++ + V ++ C PI C P C +DC +T
Sbjct: 1612 ACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTT 1663
Score = 32.7 bits (73), Expect = 3.0
Identities = 17/49 (34%), Positives = 21/49 (42%), Gaps = 6/49 (12%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
W WS+CS+TCG RR +T GR C + K C C
Sbjct: 81 WGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDC 123
Score = 32.0 bits (71), Expect = 5.1
Identities = 16/53 (30%), Positives = 25/53 (47%), Gaps = 8/53 (15%)
Query: 203 WSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLT-EFQVCQSSPC--EAEELR 252
WS+CS+TCG G + R + G C ++ C + C +AE+ R
Sbjct: 84 WSDCSRTCGGGASYSLRRCLT-----GRNCEGQNIRYKTCSNHDCPPDAEDFR 131
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 92.4 bits (228), Expect = 3e-18
Identities = 101/371 (27%), Positives = 138/371 (37%), Gaps = 78/371 (21%)
Query: 1089 PCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCM-----------QNTADGP 1137
PC S LW T W+ C VT C EG Q R RC+ T +
Sbjct: 74 PCRSP-RWSLWST--WAPCSVT-------CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQ 123
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
+ ED C CPE S WGPW C + C++ + +R A P
Sbjct: 124 LQACEDQQC---------------CPEMGGWSGWGPWEPCSVTCSKGTRTRRRA--CNHP 166
Query: 1198 ADE-GRSCP-NAVEKEPCNLNKNCYHYDYNVT--DWSTCQLSEKAVCGNGIKTRMLDCVR 1253
A + G CP A E E C+ + C + T W+ C S +TR C
Sbjct: 167 APKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
Query: 1254 SD-GKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRR 1312
+ + K C L E Q + + CPV W P S C TCGL G+ + +R
Sbjct: 227 PEPSQKPPGKPCPGLAYE---QRRCTGLPPCPVAGGWGPWGPVSPCPVTCGL-GQTMEQR 282
Query: 1313 TVTQPFQGDGRP-CPS------LMDQSKPCPVKPCYRW-QYGQWSPC---QVQEAQCGE- 1360
T P G P C + + + PCPV W +G+WSPC ++ C E
Sbjct: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG--EWDSWGEWSPCIRRNMKSISCQEI 340
Query: 1361 -GTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKD 1419
G ++R +C + D CA G + + Q CP +
Sbjct: 341 PGQQSRGRTC---------RGRKFDGHRCA-------GQQQDIRHCYSIQHCPLKGSWSE 384
Query: 1420 WSSWSLCQLTC 1430
WS+W LC C
Sbjct: 385 WSTWGLCMPPC 395
Score = 78.6 bits (192), Expect = 5e-14
Identities = 89/368 (24%), Positives = 129/368 (35%), Gaps = 80/368 (21%)
Query: 638 STWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-- 695
S WSTW+ CS TCS EG Q+R R + + G+ G P + Q +++C + C
Sbjct: 81 SLWSTWAPCSVTCS----EGSQLRYRRCVGWNGQCSGKVAPGTLEWQ-LQACEDQQCCPE 135
Query: 696 VYHWQT-GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPK---K 751
+ W GPW C +CS G +TR+ C PK
Sbjct: 136 MGGWSGWGPWEPC-----------------SVTCSKGTRTRRRAC-----NHPAPKCGGH 173
Query: 752 CPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANG- 810
CP + C + WT C +SC G ++ + P+
Sbjct: 174 CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKP 233
Query: 811 -GRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
G+ C YE++ C C W PW P CG G+
Sbjct: 234 PGKPCPGLAYEQRRCTGLPPCPV----AGGWG-----PWGPVSPCPVT---CGLGQTMEQ 281
Query: 870 ITCRKQDGGQAGIHECLQYAGPVPA----LTQACQ--IPCQDDCQLTSWSKFSSC----- 918
TC H Q+ GP A T C +PC D + SW ++S C
Sbjct: 282 RTCN---------HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNM 332
Query: 919 -NGDCGAV---RTRKRTLVGKSKKKEKCKNS-----HLYPLIETQYCPCDKYNAQPVGNW 969
+ C + ++R RT G+ +C H Y + Q+CP K + W
Sbjct: 333 KSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI---QHCPL-KGSWSEWSTW 388
Query: 970 SDCILPEG 977
C+ P G
Sbjct: 389 GLCMPPCG 396
Score = 68.2 bits (165), Expect = 6e-11
Identities = 79/346 (22%), Positives = 120/346 (34%), Gaps = 54/346 (15%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIP--CPSDCKLSEWSNWSRCSKSC 1051
C +G + + C NG+ + + +AC CP S W W CS +C
Sbjct: 93 CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC 152
Query: 1052 GSGVKVRSKWLREKPYNGGRPCPKLDHVNQA-QVYEVVPCHSDCNQYLWVT-EPWSICKV 1109
G + R + G CP ++A +V P H W T PW+ C
Sbjct: 153 SKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHG-----AWATWGPWTPCS- 206
Query: 1110 TFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK--LPCPEDCV 1167
+ E +TR +C +A PS+ C + R C PCP V
Sbjct: 207 --ASCHGGPHEPKETRSRKC---SAPEPSQKPPGKPC--PGLAYEQRRCTGLPPCP---V 256
Query: 1168 ISEWGPW---TQCVLPCNQSSFRQRSADPIRQPADEGRSCP-NAVEKEPCNLNKNC---Y 1220
WGPW + C + C ++ P G C +A CN C
Sbjct: 257 AGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG 316
Query: 1221 HYDYNVTDWSTC-----------QLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGL 1269
+D + +WS C ++ + G + R D R G+ D+++C ++
Sbjct: 317 EWD-SWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI-- 373
Query: 1270 EKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVT 1315
CP+ S+WS W C CG R+R T
Sbjct: 374 -----------QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
Score = 68.2 bits (165), Expect = 6e-11
Identities = 92/359 (25%), Positives = 129/359 (35%), Gaps = 68/359 (18%)
Query: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPV-----ACDAP--CPKDCVLSTWSTWS 644
C G+Q++ C+ +G+ C + P + AC+ CP+ S W W
Sbjct: 93 CSEGSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWE 146
Query: 645 SCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYH--WQT- 701
CS TCS +G + R R+ A + GG CP + QE +C+ H W T
Sbjct: 147 PCSVTCS----KGTRTRRRACNHPAPKCGG-HCPGQA--QESEACDTQQVCPTHGAWATW 199
Query: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVG----MQTRKVICVRVNVGQVGP-KKCPESL 756
GPW C ASC G +TR C Q P K CP
Sbjct: 200 GPWTPC-----------------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 757 RPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTD 816
+ L PC P+ + CP +C G + ++ H V P +GG C
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV----PQHGGPFCAG 298
Query: 817 PLYEEKACEAPQACQ-SYRWKTH-KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCR- 873
C C W + +W C ++++ PG+Q+R TCR
Sbjct: 299 DATRTHICNTAVPCPVDGEWDSWGEWSPC------IRRNMKSISCQEIPGQQSRGRTCRG 352
Query: 874 -KQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSWSKFSSCNGDCGAVRTRKR 930
K DG H C AG + I C + WS + C CG TR R
Sbjct: 353 RKFDG-----HRC---AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
Score = 66.2 bits (160), Expect = 2e-10
Identities = 98/373 (26%), Positives = 145/373 (38%), Gaps = 73/373 (19%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNG---GRPCP-KLDHVNQAQVYE 1086
PC S + S WS W+ CS +C G ++R + R +NG G+ P L+ Q Q E
Sbjct: 74 PCRSP-RWSLWSTWAPCSVTCSEGSQLR--YRRCVGWNGQCSGKVAPGTLEW--QLQACE 128
Query: 1087 VVPCHSDCNQYL-WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT----ADGPSEHV 1141
C + + W PW C VT C +G +TR+ C P +
Sbjct: 129 DQQCCPEMGGWSGW--GPWEPCSVT-------CSKGTRTRRRACNHPAPKCGGHCPGQAQ 179
Query: 1142 EDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCN-------QSSFRQRSA-DP 1193
E CD +++ CP + WGPWT C C+ ++ R+ SA +P
Sbjct: 180 ESEACDTQQV----------CPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP 229
Query: 1194 IRQPADEGRSCPN-AVEKEPCNLNKNCYHYDYNVTDW---STCQLSEKAVCGNGIKTRML 1249
++P G+ CP A E+ C C W S C ++ CG G
Sbjct: 230 SQKP--PGKPCPGLAYEQRRCTGLPPC-PVAGGWGPWGPVSPCPVT----CGLGQTMEQR 282
Query: 1250 DC---VRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSEC------SQ 1300
C V G +C A + NT+ V CPV+ + W WS C S
Sbjct: 283 TCNHPVPQHGG----PFC-AGDATRTHICNTA--VPCPVDGEWDSWGEWSPCIRRNMKSI 335
Query: 1301 TC-GLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPC-PVKPC-YRWQYGQWSPCQVQEAQ 1357
+C + G+ R RT + + DG C + C ++ C + + +WS +
Sbjct: 336 SCQEIPGQQSRGRT-CRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPP 394
Query: 1358 CGEG-TRTRNISC 1369
CG TR R C
Sbjct: 395 CGPNPTRARQRLC 407
Score = 57.8 bits (138), Expect = 9e-08
Identities = 84/329 (25%), Positives = 113/329 (34%), Gaps = 47/329 (14%)
Query: 516 SPWSAWGPCTYENCNDQQGKKGFKLRKRRIT--NEPTGGSGVTGNCPHLLEAIPCEEPAC 573
S WS W PC+ C++ G +LR RR N G G L+A CE+ C
Sbjct: 81 SLWSTWAPCSV-TCSE-----GSQLRYRRCVGWNGQCSGKVAPGTLEWQLQA--CEDQQC 132
Query: 574 YD----WKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDA 629
W G EP + C GT+ + C N + A ACD
Sbjct: 133 CPEMGGWSG--WGPWEPCS-VTCSKGTRTRRRAC-NHPAPKCGGHCPGQA--QESEACDT 186
Query: 630 P--CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVR 687
CP +TW W+ CS +C G E K+ R+R A + P E R
Sbjct: 187 QQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQR 246
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
C P GPWG VS T C +G + C V Q
Sbjct: 247 RCTGLPPCPVAGGWGPWG------PVSPCPVT--------CGLGQTMEQRTC-NHPVPQH 291
Query: 748 GPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSC------PSSCKEGDSSIRKQSRHR 801
G C + +PC D + +W+ C SC+E +QSR R
Sbjct: 292 GGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG---QQSRGR 348
Query: 802 VIIQLPANGGRDCTDPLYEEKACEAPQAC 830
+G R C + + C + Q C
Sbjct: 349 TCRGRKFDGHR-CAGQQQDIRHCYSIQHC 376
Score = 55.1 bits (131), Expect = 6e-07
Identities = 94/369 (25%), Positives = 121/369 (32%), Gaps = 91/369 (24%)
Query: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTF----QSCVITKECQV----SEWSEWSPCS 373
G Q R C+ G+ C + P T Q+C + C S W W PCS
Sbjct: 96 GSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS 149
Query: 374 KTCHDMVSPAGTRVRTRTIRQFPIGSEKECP-EFEEKEPCLSQGDGVVPCATYG-WRTT- 430
TC GTR R R CP + +E E C +Q C T+G W T
Sbjct: 150 VTCSK-----GTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQ----VCPTHGAWATWG 200
Query: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGI----QTREVYCVQANENLLSQLSTHKNKEAS 486
WT C +A C GG +TR C + K
Sbjct: 201 PWTPC----------------SASCHGGPHEPKETRSRKCSAPEPS---------QKPPG 235
Query: 487 KPM-----DLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
KP + + CTG +P PCP PW PC C Q
Sbjct: 236 KPCPGLAYEQRRCTG-LP--------PCPVAGGWGPWGPVSPCPV-TCGLGQ------TM 279
Query: 542 KRRITNEPT---GGSGVTGNCP--HLLE-AIPCEEPACYD----WKAVRLGNCEPDNGKE 591
++R N P GG G+ H+ A+PC +D W N + + +E
Sbjct: 280 EQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQE 339
Query: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAP-CPKDCVLSTWSTWSSCSHTC 650
PG Q + C G + D C I CP S WSTW C C
Sbjct: 340 I-PGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
Query: 651 SGKTTEGKQ 659
T +Q
Sbjct: 396 GPNPTRARQ 404
Score = 51.2 bits (121), Expect = 8e-06
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 28/150 (18%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMD-QSKPCPVKPCYR----WQ-Y 1345
WS W+ CS TC ++ RR V Q G+ P ++ Q + C + C W +
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
Query: 1346 GQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEE 1405
G W PC V C +GTRTR +C +E E
Sbjct: 143 GPWEPCSVT---CSKGTRTRRRACNHPAPKCGGHCPGQAQE-----------------SE 182
Query: 1406 SCS--QPCPGDCYLKDWSSWSLCQLTCVNG 1433
+C Q CP W W+ C +C G
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGG 212
Score = 44.3 bits (103), Expect = 0.001
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVA-PPQFGGSGCPNLTEFQV--CQSSPCEAEELRYS 254
S +S W+ CS TC G Q R R V Q G P E+Q+ C+ C E +S
Sbjct: 81 SLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS 140
Query: 255 LHVGPWSTCSMPHSRQVRQARR 276
GPW CS+ S+ R RR
Sbjct: 141 -GWGPWEPCSVTCSKGTRTRRR 161
Score = 37.7 bits (86), Expect = 0.093
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 13/101 (12%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHV 257
S + W CS TC G + R R P G CP Q +S C+ +++ +
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPG----QAQESEACDTQQVCPTHGA 195
Query: 258 ----GPWSTCSM-----PHSRQVRQARRRGKNKEREKDRSK 289
GPW+ CS PH + ++R+ + +K K
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236
Score = 32.0 bits (71), Expect = 5.1
Identities = 33/135 (24%), Positives = 47/135 (34%), Gaps = 26/135 (19%)
Query: 1338 KPCYRWQYGQWS---PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELI 1394
+PC ++ WS PC V C EG++ R CV +G KV ++
Sbjct: 73 QPCRSPRWSLWSTWAPCSV---TCSEGSQLRYRRCVGWNGQCS--GKVAPGTLEWQLQAC 127
Query: 1395 IDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELE 1454
D Q CP W W C +TC G + R R +
Sbjct: 128 ED-----------QQCCPEMGGWSGWGPWEPCSVTCSK-------GTRTRRRACNHPAPK 169
Query: 1455 NQHLCPEQMLETKSC 1469
CP Q E+++C
Sbjct: 170 CGGHCPGQAQESEAC 184
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 92.4 bits (228), Expect = 3e-18
Identities = 101/371 (27%), Positives = 138/371 (37%), Gaps = 78/371 (21%)
Query: 1089 PCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCM-----------QNTADGP 1137
PC S LW T W+ C VT C EG Q R RC+ T +
Sbjct: 74 PCRSP-RWSLWST--WAPCSVT-------CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQ 123
Query: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
+ ED C CPE S WGPW C + C++ + +R A P
Sbjct: 124 LQACEDQQC---------------CPEMGGWSGWGPWEPCSVTCSKGTRTRRRA--CNHP 166
Query: 1198 ADE-GRSCP-NAVEKEPCNLNKNCYHYDYNVT--DWSTCQLSEKAVCGNGIKTRMLDCVR 1253
A + G CP A E E C+ + C + T W+ C S +TR C
Sbjct: 167 APKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSA 226
Query: 1254 SD-GKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRR 1312
+ + K C L E Q + + CPV W P S C TCGL G+ + +R
Sbjct: 227 PEPSQKPPGKPCPGLAYE---QRRCTGLPPCPVAGGWGPWGPVSPCPVTCGL-GQTMEQR 282
Query: 1313 TVTQPFQGDGRP-CPS------LMDQSKPCPVKPCYRW-QYGQWSPC---QVQEAQCGE- 1360
T P G P C + + + PCPV W +G+WSPC ++ C E
Sbjct: 283 TCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG--EWDSWGEWSPCIRRNMKSISCQEI 340
Query: 1361 -GTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKD 1419
G ++R +C + D CA G + + Q CP +
Sbjct: 341 PGQQSRGRTC---------RGRKFDGHRCA-------GQQQDIRHCYSIQHCPLKGSWSE 384
Query: 1420 WSSWSLCQLTC 1430
WS+W LC C
Sbjct: 385 WSTWGLCMPPC 395
Score = 78.6 bits (192), Expect = 5e-14
Identities = 89/368 (24%), Positives = 129/368 (35%), Gaps = 80/368 (21%)
Query: 638 STWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCT-- 695
S WSTW+ CS TCS EG Q+R R + + G+ G P + Q +++C + C
Sbjct: 81 SLWSTWAPCSVTCS----EGSQLRYRRCVGWNGQCSGKVAPGTLEWQ-LQACEDQQCCPE 135
Query: 696 VYHWQT-GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPK---K 751
+ W GPW C +CS G +TR+ C PK
Sbjct: 136 MGGWSGWGPWEPC-----------------SVTCSKGTRTRRRAC-----NHPAPKCGGH 173
Query: 752 CPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANG- 810
CP + C + WT C +SC G ++ + P+
Sbjct: 174 CPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKP 233
Query: 811 -GRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARA 869
G+ C YE++ C C W PW P CG G+
Sbjct: 234 PGKPCPGLAYEQRRCTGLPPCPV----AGGWG-----PWGPVSPCPVT---CGLGQTMEQ 281
Query: 870 ITCRKQDGGQAGIHECLQYAGPVPA----LTQACQ--IPCQDDCQLTSWSKFSSC----- 918
TC H Q+ GP A T C +PC D + SW ++S C
Sbjct: 282 RTCN---------HPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNM 332
Query: 919 -NGDCGAV---RTRKRTLVGKSKKKEKCKNS-----HLYPLIETQYCPCDKYNAQPVGNW 969
+ C + ++R RT G+ +C H Y + Q+CP K + W
Sbjct: 333 KSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI---QHCPL-KGSWSEWSTW 388
Query: 970 SDCILPEG 977
C+ P G
Sbjct: 389 GLCMPPCG 396
Score = 68.2 bits (165), Expect = 6e-11
Identities = 79/346 (22%), Positives = 120/346 (34%), Gaps = 54/346 (15%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIP--CPSDCKLSEWSNWSRCSKSC 1051
C +G + + C NG+ + + +AC CP S W W CS +C
Sbjct: 93 CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTC 152
Query: 1052 GSGVKVRSKWLREKPYNGGRPCPKLDHVNQA-QVYEVVPCHSDCNQYLWVT-EPWSICKV 1109
G + R + G CP ++A +V P H W T PW+ C
Sbjct: 153 SKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHG-----AWATWGPWTPCS- 206
Query: 1110 TFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK--LPCPEDCV 1167
+ E +TR +C +A PS+ C + R C PCP V
Sbjct: 207 --ASCHGGPHEPKETRSRKC---SAPEPSQKPPGKPC--PGLAYEQRRCTGLPPCP---V 256
Query: 1168 ISEWGPW---TQCVLPCNQSSFRQRSADPIRQPADEGRSCP-NAVEKEPCNLNKNC---Y 1220
WGPW + C + C ++ P G C +A CN C
Sbjct: 257 AGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDG 316
Query: 1221 HYDYNVTDWSTC-----------QLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGL 1269
+D + +WS C ++ + G + R D R G+ D+++C ++
Sbjct: 317 EWD-SWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSI-- 373
Query: 1270 EKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVT 1315
CP+ S+WS W C CG R+R T
Sbjct: 374 -----------QHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCT 408
Score = 68.2 bits (165), Expect = 6e-11
Identities = 92/359 (25%), Positives = 129/359 (35%), Gaps = 68/359 (18%)
Query: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPV-----ACDAP--CPKDCVLSTWSTWS 644
C G+Q++ C+ +G+ C + P + AC+ CP+ S W W
Sbjct: 93 CSEGSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWE 146
Query: 645 SCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYH--WQT- 701
CS TCS +G + R R+ A + GG CP + QE +C+ H W T
Sbjct: 147 PCSVTCS----KGTRTRRRACNHPAPKCGG-HCPGQA--QESEACDTQQVCPTHGAWATW 199
Query: 702 GPWGQCIEDTSVSSFNTTTTWNGEASCSVG----MQTRKVICVRVNVGQVGP-KKCPESL 756
GPW C ASC G +TR C Q P K CP
Sbjct: 200 GPWTPC-----------------SASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 757 RPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTD 816
+ L PC P+ + CP +C G + ++ H V P +GG C
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPV----PQHGGPFCAG 298
Query: 817 PLYEEKACEAPQACQ-SYRWKTH-KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCR- 873
C C W + +W C ++++ PG+Q+R TCR
Sbjct: 299 DATRTHICNTAVPCPVDGEWDSWGEWSPC------IRRNMKSISCQEIPGQQSRGRTCRG 352
Query: 874 -KQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSWSKFSSCNGDCGAVRTRKR 930
K DG H C AG + I C + WS + C CG TR R
Sbjct: 353 RKFDG-----HRC---AGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCGPNPTRAR 403
Score = 66.2 bits (160), Expect = 2e-10
Identities = 98/373 (26%), Positives = 145/373 (38%), Gaps = 73/373 (19%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNG---GRPCP-KLDHVNQAQVYE 1086
PC S + S WS W+ CS +C G ++R + R +NG G+ P L+ Q Q E
Sbjct: 74 PCRSP-RWSLWSTWAPCSVTCSEGSQLR--YRRCVGWNGQCSGKVAPGTLEW--QLQACE 128
Query: 1087 VVPCHSDCNQYL-WVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT----ADGPSEHV 1141
C + + W PW C VT C +G +TR+ C P +
Sbjct: 129 DQQCCPEMGGWSGW--GPWEPCSVT-------CSKGTRTRRRACNHPAPKCGGHCPGQAQ 179
Query: 1142 EDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCN-------QSSFRQRSA-DP 1193
E CD +++ CP + WGPWT C C+ ++ R+ SA +P
Sbjct: 180 ESEACDTQQV----------CPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEP 229
Query: 1194 IRQPADEGRSCPN-AVEKEPCNLNKNCYHYDYNVTDW---STCQLSEKAVCGNGIKTRML 1249
++P G+ CP A E+ C C W S C ++ CG G
Sbjct: 230 SQKP--PGKPCPGLAYEQRRCTGLPPC-PVAGGWGPWGPVSPCPVT----CGLGQTMEQR 282
Query: 1250 DC---VRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSEC------SQ 1300
C V G +C A + NT+ V CPV+ + W WS C S
Sbjct: 283 TCNHPVPQHGG----PFC-AGDATRTHICNTA--VPCPVDGEWDSWGEWSPCIRRNMKSI 335
Query: 1301 TC-GLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPC-PVKPC-YRWQYGQWSPCQVQEAQ 1357
+C + G+ R RT + + DG C + C ++ C + + +WS +
Sbjct: 336 SCQEIPGQQSRGRT-CRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPP 394
Query: 1358 CGEG-TRTRNISC 1369
CG TR R C
Sbjct: 395 CGPNPTRARQRLC 407
Score = 57.8 bits (138), Expect = 9e-08
Identities = 84/329 (25%), Positives = 113/329 (34%), Gaps = 47/329 (14%)
Query: 516 SPWSAWGPCTYENCNDQQGKKGFKLRKRRIT--NEPTGGSGVTGNCPHLLEAIPCEEPAC 573
S WS W PC+ C++ G +LR RR N G G L+A CE+ C
Sbjct: 81 SLWSTWAPCSV-TCSE-----GSQLRYRRCVGWNGQCSGKVAPGTLEWQLQA--CEDQQC 132
Query: 574 YD----WKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDA 629
W G EP + C GT+ + C N + A ACD
Sbjct: 133 CPEMGGWSG--WGPWEPCS-VTCSKGTRTRRRAC-NHPAPKCGGHCPGQA--QESEACDT 186
Query: 630 P--CPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVR 687
CP +TW W+ CS +C G E K+ R+R A + P E R
Sbjct: 187 QQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQR 246
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
C P GPWG VS T C +G + C V Q
Sbjct: 247 RCTGLPPCPVAGGWGPWG------PVSPCPVT--------CGLGQTMEQRTC-NHPVPQH 291
Query: 748 GPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSC------PSSCKEGDSSIRKQSRHR 801
G C + +PC D + +W+ C SC+E +QSR R
Sbjct: 292 GGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPG---QQSRGR 348
Query: 802 VIIQLPANGGRDCTDPLYEEKACEAPQAC 830
+G R C + + C + Q C
Sbjct: 349 TCRGRKFDGHR-CAGQQQDIRHCYSIQHC 376
Score = 55.1 bits (131), Expect = 6e-07
Identities = 94/369 (25%), Positives = 121/369 (32%), Gaps = 91/369 (24%)
Query: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTF----QSCVITKECQV----SEWSEWSPCS 373
G Q R C+ G+ C + P T Q+C + C S W W PCS
Sbjct: 96 GSQLRYRRCVGWNGQ------CSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS 149
Query: 374 KTCHDMVSPAGTRVRTRTIRQFPIGSEKECP-EFEEKEPCLSQGDGVVPCATYG-WRTT- 430
TC GTR R R CP + +E E C +Q C T+G W T
Sbjct: 150 VTCSK-----GTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQ----VCPTHGAWATWG 200
Query: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGI----QTREVYCVQANENLLSQLSTHKNKEAS 486
WT C +A C GG +TR C + K
Sbjct: 201 PWTPC----------------SASCHGGPHEPKETRSRKCSAPEPS---------QKPPG 235
Query: 487 KPM-----DLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
KP + + CTG +P PCP PW PC C Q
Sbjct: 236 KPCPGLAYEQRRCTG-LP--------PCPVAGGWGPWGPVSPCPV-TCGLGQ------TM 279
Query: 542 KRRITNEPT---GGSGVTGNCP--HLLE-AIPCEEPACYD----WKAVRLGNCEPDNGKE 591
++R N P GG G+ H+ A+PC +D W N + + +E
Sbjct: 280 EQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKSISCQE 339
Query: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAP-CPKDCVLSTWSTWSSCSHTC 650
PG Q + C G + D C I CP S WSTW C C
Sbjct: 340 I-PGQQSRGRTC---RGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPC 395
Query: 651 SGKTTEGKQ 659
T +Q
Sbjct: 396 GPNPTRARQ 404
Score = 51.2 bits (121), Expect = 8e-06
Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 28/150 (18%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMD-QSKPCPVKPCYR----WQ-Y 1345
WS W+ CS TC ++ RR V Q G+ P ++ Q + C + C W +
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGW 142
Query: 1346 GQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEE 1405
G W PC V C +GTRTR +C +E E
Sbjct: 143 GPWEPCSVT---CSKGTRTRRRACNHPAPKCGGHCPGQAQE-----------------SE 182
Query: 1406 SCS--QPCPGDCYLKDWSSWSLCQLTCVNG 1433
+C Q CP W W+ C +C G
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGG 212
Score = 44.3 bits (103), Expect = 0.001
Identities = 30/82 (36%), Positives = 38/82 (46%), Gaps = 4/82 (4%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVA-PPQFGGSGCPNLTEFQV--CQSSPCEAEELRYS 254
S +S W+ CS TC G Q R R V Q G P E+Q+ C+ C E +S
Sbjct: 81 SLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWS 140
Query: 255 LHVGPWSTCSMPHSRQVRQARR 276
GPW CS+ S+ R RR
Sbjct: 141 -GWGPWEPCSVTCSKGTRTRRR 161
Score = 37.7 bits (86), Expect = 0.093
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 13/101 (12%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHV 257
S + W CS TC G + R R P G CP Q +S C+ +++ +
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPG----QAQESEACDTQQVCPTHGA 195
Query: 258 ----GPWSTCSM-----PHSRQVRQARRRGKNKEREKDRSK 289
GPW+ CS PH + ++R+ + +K K
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGK 236
Score = 32.0 bits (71), Expect = 5.1
Identities = 33/135 (24%), Positives = 47/135 (34%), Gaps = 26/135 (19%)
Query: 1338 KPCYRWQYGQWS---PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELI 1394
+PC ++ WS PC V C EG++ R CV +G KV ++
Sbjct: 73 QPCRSPRWSLWSTWAPCSV---TCSEGSQLRYRRCVGWNGQCS--GKVAPGTLEWQLQAC 127
Query: 1395 IDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELE 1454
D Q CP W W C +TC G + R R +
Sbjct: 128 ED-----------QQCCPEMGGWSGWGPWEPCSVTCSK-------GTRTRRRACNHPAPK 169
Query: 1455 NQHLCPEQMLETKSC 1469
CP Q E+++C
Sbjct: 170 CGGHCPGQAQESEAC 184
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
sapiens]
Length = 1584
Score = 88.6 bits (218), Expect = 5e-17
Identities = 91/342 (26%), Positives = 127/342 (37%), Gaps = 76/342 (22%)
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCP-KLDHVNQAQVYEVVPC--HSDCNQY 1097
WS W C++ CG G++ R++ P G C L+ Q P S +Q
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQS 326
Query: 1098 LWVTE------------------------------PWSICKVTFVNMRENCGEGVQTRKV 1127
L T+ PWS+C T CGEG QTR
Sbjct: 327 LRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSST-------CGEGWQTRTR 379
Query: 1128 RCMQNT----ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQ 1183
C+ ++ GP E LC+ + CP EW PW+ C C +
Sbjct: 380 FCVSSSYSTQCSGPLR--EQRLCNNSAV----------CPVHGAWDEWSPWSLCSSTCGR 427
Query: 1184 SSFRQRSADPIRQPADEGRSCPNAVEKEP--CNLNKNC--YHYDYNVTDWSTCQLSEKAV 1239
FR R+ R P G C EK+ CN+ C D N +WS+ A
Sbjct: 428 -GFRDRTR-TCRPPQFGGNPC-EGPEKQTKFCNI-ALCPGRAVDGNWNEWSSWSAC-SAS 482
Query: 1240 CGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMV-ECPVNCQLSDWSPWSEC 1298
C G + R +C +G S C+ +W C + +CPV+ + W+ W C
Sbjct: 483 CSQGRQQRTREC---NGPSYGGAECQG-----HWVETRDCFLQQCPVDGKWQAWASWGSC 534
Query: 1299 SQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
S TCG G R R + PF G G C D+ + C + C
Sbjct: 535 SVTCG-AGSQRRERVCSGPFFG-GAACQGPQDEYRQCGTQRC 574
Score = 77.8 bits (190), Expect = 8e-14
Identities = 63/211 (29%), Positives = 84/211 (39%), Gaps = 38/211 (18%)
Query: 1229 WSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQ 1288
WS C + CG G +TR CV S + C E+ N++ CPV+
Sbjct: 363 WSVCS----STCGEGWQTRTRFCVSSSYST----QCSGPLREQRLCNNSAV---CPVHGA 411
Query: 1289 LSDWSPWSECSQTCGLTGKMIRRRTVT-QPFQGDGRPCPSLMDQSKPCPVKPC----YRW 1343
+WSPWS CS TC G+ R RT T +P Q G PC Q+K C + C
Sbjct: 412 WDEWSPWSLCSSTC---GRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDG 468
Query: 1344 QYGQWSPCQVQEAQCGEGTRTRNISC-VVSDGSADDFSKVVDEEFCADIELIIDGNKNMV 1402
+ +WS A C +G + R C S G A+ V+ C
Sbjct: 469 NWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDC-------------- 514
Query: 1403 LEESCSQPCPGDCYLKDWSSWSLCQLTCVNG 1433
Q CP D + W+SW C +TC G
Sbjct: 515 ----FLQQCPVDGKWQAWASWGSCSVTCGAG 541
Score = 68.9 bits (167), Expect = 4e-11
Identities = 91/357 (25%), Positives = 126/357 (35%), Gaps = 72/357 (20%)
Query: 640 WSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHW 699
WS W C+ C G G Q R R+ L G EGG C L+E R CN C
Sbjct: 267 WSLWGECTRDCGG----GLQTRTRTCLPAPGVEGG-GC--EGVLEEGRQCNREACGPAG- 318
Query: 700 QTGPWGQCIEDTS----------VSSFNTTTTWNGE-------------ASCSVGMQTRK 736
+T Q + T + F G+ ++C G QTR
Sbjct: 319 RTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRT 378
Query: 737 VICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRK 796
CV + +C LR + + C +S W+ C S+C G R
Sbjct: 379 RFCVSSSYST----QCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRG---FRD 431
Query: 797 QSRHRVIIQLPANGGRDCTDPLYEEKACE---APQACQSYRWKTHKWRRCQLVPWSVQQD 853
++R + P GG C P + K C P W ++W WS
Sbjct: 432 RTR---TCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNW--NEWSS-----WSACSA 481
Query: 854 SPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSW 912
S C GRQ R C +G G EC + T+ C + C D + +W
Sbjct: 482 S------CSQGRQQRTREC---NGPSYGGAECQGHW----VETRDCFLQQCPVDGKWQAW 528
Query: 913 SKFSSCNGDCGA-VRTRKRTLVGKSKKKEKCKN-SHLYPLIETQYCP-----CDKYN 962
+ + SC+ CGA + R+R G C+ Y TQ CP CD+ N
Sbjct: 529 ASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDN 585
Score = 65.9 bits (159), Expect = 3e-10
Identities = 68/263 (25%), Positives = 94/263 (35%), Gaps = 50/263 (19%)
Query: 994 CGQGYRYQAMACYDQN------GRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRC 1047
CG+G++ + C + G L E CN+ CP EWS WS C
Sbjct: 370 CGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAV--------CPVHGAWDEWSPWSLC 421
Query: 1048 SKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS---DCNQYLWVTEPW 1104
S +CG G + R++ R P GG PC + Q + + C D N W W
Sbjct: 422 SSTCGRGFRDRTRTCR-PPQFGGNPCEGPE--KQTKFCNIALCPGRAVDGNWNEW--SSW 476
Query: 1105 SICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKL-PCP 1163
S C +C +G Q R C +GPS + C + +R C L CP
Sbjct: 477 SACSA-------SCSQGRQQRTREC-----NGPSYGGAE--CQGHWVE--TRDCFLQQCP 520
Query: 1164 EDCVISEWGPWTQCVLPCNQSSFRQR--------SADPIRQPADEGRSCPNAVEKEPCNL 1215
D W W C + C S R+ + P DE R C EP
Sbjct: 521 VDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEP--- 577
Query: 1216 NKNCYHYDYNVTDWSTCQLSEKA 1238
++ C ++ W E A
Sbjct: 578 HEICDEDNFGAVIWKETPAGEVA 600
Score = 65.1 bits (157), Expect = 5e-10
Identities = 83/354 (23%), Positives = 126/354 (35%), Gaps = 85/354 (24%)
Query: 912 WSKFSSCNGDCGA-VRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWS 970
WS + C DCG ++TR RT + P +E G
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPA-------------PGVE--------------GGGC 299
Query: 971 DCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACII 1030
+ +L EG+ Q + + CG R + + Q+ R + R G +
Sbjct: 300 EGVLEEGR---------QCNREACGPAGRTSSRS---QSLRSTDARRREELGDELQQFGF 347
Query: 1031 PCPS--DCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV 1088
P P D EWS WS CS +CG G + R+++ Y+ P L V
Sbjct: 348 PAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGP-LREQRLCNNSAVC 406
Query: 1089 PCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQ-----NTADGPSEHVED 1143
P H +++ PWS+C T CG G + R C N +GP +
Sbjct: 407 PVHGAWDEW----SPWSLCSST-------CGRGFRDRTRTCRPPQFGGNPCEGPEKQ--- 452
Query: 1144 YLCDPEEMPLGSRVCKLP-CPEDCV---ISEWGPWTQCVLPCNQSSFRQRSADPIRQPAD 1199
++ C + CP V +EW W+ C C+Q RQ+ P+
Sbjct: 453 -----------TKFCNIALCPGRAVDGNWNEWSSWSACSASCSQG--RQQRTRECNGPSY 499
Query: 1200 EGRSCP-NAVEKEPCNLNKNCYHYDYNV-TDWSTCQLSEKAVCGNGIKTRMLDC 1251
G C + VE C L + + W +C ++ CG G + R C
Sbjct: 500 GGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVT----CGAGSQRRERVC 549
Score = 63.2 bits (152), Expect = 2e-09
Identities = 83/348 (23%), Positives = 121/348 (34%), Gaps = 88/348 (25%)
Query: 518 WSAWGPCTYENCNDQQ---------------GKKGFKLRKRRITNEPTGGSGVTGNCPHL 562
WS WG CT + Q G +G R+ E G +G T +
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQS 326
Query: 563 LEAIPCEEPACYDWKAVRLGNCEPDNG--------------KECGPGTQVQEVVCINSD- 607
L + + + G P G CG G Q + C++S
Sbjct: 327 LRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSY 386
Query: 608 -----GEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRA 662
G +++LC ++ A CP WS WS CS TC G+ R
Sbjct: 387 STQCSGPLREQRLCNNS---------AVCPVHGAWDEWSPWSLCSSTC------GRGFRD 431
Query: 663 RSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTW 722
R+ + GG C ++ + CN C G+ ++ ++N ++W
Sbjct: 432 RTRTCRPPQFGGNPCEGPE--KQTKFCNIALCP---------GRAVD----GNWNEWSSW 476
Query: 723 NG-EASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLL-PCKKDCIVTPYSDW 780
+ ASCS G Q R C N G +C + ET R C L C D ++ W
Sbjct: 477 SACSASCSQGRQQRTREC---NGPSYGGAEC-QGHWVET-RDCFLQQCPVDGKWQAWASW 531
Query: 781 TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQ 828
SC +C G Q R RV C+ P + AC+ PQ
Sbjct: 532 GSCSVTCGAG-----SQRRERV-----------CSGPFFGGAACQGPQ 563
Score = 61.2 bits (147), Expect = 8e-09
Identities = 76/327 (23%), Positives = 106/327 (32%), Gaps = 98/327 (29%)
Query: 1292 WSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC----------- 1340
WS W EC++ CG G R RT +G C ++++ + C + C
Sbjct: 267 WSLWGECTRDCG-GGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQ 325
Query: 1341 ---------------YRWQYG------------QWSPCQVQEAQCGEGTRTRNISCVVSD 1373
Q+G +WSP V + CGEG +TR CV S
Sbjct: 326 SLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSS 385
Query: 1374 GSADDFSKVVDEEFCADIELI-----------------IDGNKNMVLEESCSQP------ 1410
S + ++ C + + G +C P
Sbjct: 386 YSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNP 445
Query: 1411 ---------------CPG---DCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQE 1452
CPG D +WSSWS C +C G Q R+R
Sbjct: 446 CEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGR-------QQRTRECNGPS 498
Query: 1453 LENQHLCPEQMLETKSCYDGQC-YEYKWMASAWKGSSRTVWC----QRSDGI---NVTGG 1504
C +ET+ C+ QC + KW A A GS +V C QR + + GG
Sbjct: 499 YGGAE-CQGHWVETRDCFLQQCPVDGKWQAWASWGSC-SVTCGAGSQRRERVCSGPFFGG 556
Query: 1505 CLVMSQPDADRSCNPP-CSQPHSYCSE 1530
D R C C +PH C E
Sbjct: 557 AACQGPQDEYRQCGTQRCPEPHEICDE 583
Score = 53.9 bits (128), Expect = 1e-06
Identities = 94/424 (22%), Positives = 127/424 (29%), Gaps = 149/424 (35%)
Query: 366 WSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECP-EFEEKEPCLSQGDGVVPCAT 424
WS W C++ C G + RTRT P C EE C + G +
Sbjct: 267 WSLWGECTRDC-----GGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTS 321
Query: 425 YGWRTTEWTECRVDPLLSQQDKRRGNQ------------------TALCGGGIQTREVYC 466
++ T+ R L + ++ G ++ CG G QTR +C
Sbjct: 322 SRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFC 381
Query: 467 VQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCH--IPCPTECEVSPWSAWGPC 524
V S ST C+GP+ +LC+ CP WS W C
Sbjct: 382 VS------SSYSTQ-------------CSGPL-REQRLCNNSAVCPVHGAWDEWSPWSLC 421
Query: 525 TYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNC 584
+ C +GF+ R R GG+ PCE
Sbjct: 422 S-STCG-----RGFRDRTRTCRPPQFGGN-------------PCE--------------- 447
Query: 585 EPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWS 644
G E + C A+ CP V W+ WS
Sbjct: 448 -----------------------GPEKQTKFCNIAL----------CPGRAVDGNWNEWS 474
Query: 645 SCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTV-YHWQT-G 702
S S CS ++G+Q R R GG C E R C C V WQ
Sbjct: 475 SWS-ACSASCSQGRQQRTRE--CNGPSYGGAECQGHWV--ETRDCFLQQCPVDGKWQAWA 529
Query: 703 PWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVG------------QVGPK 750
WG C +C G Q R+ +C G Q G +
Sbjct: 530 SWGSC-----------------SVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQ 572
Query: 751 KCPE 754
+CPE
Sbjct: 573 RCPE 576
Score = 52.8 bits (125), Expect = 3e-06
Identities = 70/260 (26%), Positives = 87/260 (33%), Gaps = 69/260 (26%)
Query: 60 LWKTGPWGRCMGDECGPGGIQTRAVWCAHV-------------EGWTTLHTNCKQAERPN 106
LW WG C D CG GG+QTR C EG C A R +
Sbjct: 266 LWSL--WGECTRD-CG-GGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTS 321
Query: 107 NQQNCFKVCDWHK--ELYD-------------------WRLGPWNQCQPVISKSLEKPLE 145
++ + D + EL D W PW+ C
Sbjct: 322 SRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEW--SPWSVCSSTCG-------- 371
Query: 146 CIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACL---IPCQQDCIVSEFSA 202
EG Q R C+ PL EQ C E+S
Sbjct: 372 -----EGWQTRTRFCVSSSYSTQCSG---------PLREQRLCNNSAVCPVHGAWDEWSP 417
Query: 203 WSECSKTCGSGLQHRTRHVVAPPQFGGSGCPN-LTEFQVCQSSPCEAEELRYSLHV-GPW 260
WS CS TCG G + RTR PPQFGG+ C + + C + C + + + W
Sbjct: 418 WSLCSSTCGRGFRDRTR-TCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSW 476
Query: 261 STCSMPHSRQVRQARRRGKN 280
S CS S Q RQ R R N
Sbjct: 477 SACSASCS-QGRQQRTRECN 495
Score = 47.4 bits (111), Expect = 1e-04
Identities = 75/356 (21%), Positives = 120/356 (33%), Gaps = 77/356 (21%)
Query: 358 TKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGD 417
T + EWS WS CS TC + G + RTR ++ P E++ L
Sbjct: 352 TGDPAAEEWSPWSVCSSTCGE-----GWQTRTRFCVSSSYSTQCSGPLREQR---LCNNS 403
Query: 418 GVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQL 477
V P + W+ C ++ CG G + R C
Sbjct: 404 AVCPVHGAWDEWSPWSLC----------------SSTCGRGFRDRTRTC----------- 436
Query: 478 STHKNKEASKPMDLKLCTGPIPNTTQLCHIP-CP---TECEVSPWSAWGPCTYENCNDQQ 533
+ P C GP T+ C+I CP + + WS+W C+ +C+
Sbjct: 437 --RPPQFGGNP-----CEGP-EKQTKFCNIALCPGRAVDGNWNEWSSWSACS-ASCS--- 484
Query: 534 GKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKA-VRLGNCEPDNGKEC 592
+G + R R GG+ G+ + + P W+A G+C C
Sbjct: 485 --QGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSC----SVTC 538
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSG 652
G G+Q +E VC G C+ CP+ H
Sbjct: 539 GAGSQRRERVC---SGPFFGGAACQGPQDEYRQCGTQRCPE-------------PHEICD 582
Query: 653 KTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCI 708
+ G I + AGE +RCP ++ +R C + +W+ + +C+
Sbjct: 583 EDNFGAVIWKET---PAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCV 635
Score = 47.4 bits (111), Expect = 1e-04
Identities = 51/204 (25%), Positives = 74/204 (36%), Gaps = 32/204 (15%)
Query: 65 PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDW 124
PW C CG G QTR +C ++ T C R N VC H +W
Sbjct: 362 PWSVC-SSTCGEGW-QTRTRFCVS----SSYSTQCSGPLREQRLCNNSAVCPVHGAWDEW 415
Query: 125 RLGPWNQCQPVISKSL-EKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLL 183
PW+ C + ++ C + G CE E +
Sbjct: 416 --SPWSLCSSTCGRGFRDRTRTCRPPQFGGNP------------------CEGPEKQTKF 455
Query: 184 EQACLIPCQQ-DCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCP-NLTEFQVC 241
L P + D +E+S+WS CS +C G Q RTR P +GG+ C + E + C
Sbjct: 456 CNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNG-PSYGGAECQGHWVETRDC 514
Query: 242 QSSPCEAEELRYSLHVGPWSTCSM 265
C + + W +CS+
Sbjct: 515 FLQQCPVDGKWQAW--ASWGSCSV 536
Score = 40.8 bits (94), Expect = 0.011
Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 2/57 (3%)
Query: 191 CQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPN-LTEFQVCQSSPC 246
C D +++W CS TCG+G Q R R V + P FGG+ C E++ C + C
Sbjct: 519 CPVDGKWQAWASWGSCSVTCGAGSQRRER-VCSGPFFGGAACQGPQDEYRQCGTQRC 574
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 86.7 bits (213), Expect = 2e-16
Identities = 95/347 (27%), Positives = 131/347 (37%), Gaps = 73/347 (21%)
Query: 848 WSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPV--PALTQACQIPCQD 905
WS+ Q CG G C + Q C PV P + A P
Sbjct: 878 WSIVQSE--CSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY- 934
Query: 906 DCQLTSW--SKFSSCNGDC-GAVRTRKRTLVGKSK-KKEKCKNSHLYPL-IETQYCPCDK 960
W ++S+C+ C G ++RK V K +KE+ L P+ TQ C+
Sbjct: 935 ------WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNS 988
Query: 961 YNAQP---VGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSR 1017
+ P +G WS C K CG+G R + + C + S+
Sbjct: 989 HACPPQWSLGPWSQCS------------------KTCGRGVRKRELLCKGSAAETLPESQ 1030
Query: 1018 CNS--HGYIEEACIIP-CPSDCKLSEW--SNWSRCSKSCGSGVKVRSKWLREKPYNG--- 1069
C S ++E C++ CP + +L +W S+WS CS +CG GV+ R EK + G
Sbjct: 1031 CTSLPRPELQEGCVLGRCPKNSRL-QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLI 1089
Query: 1070 ---GRPC-----PKLDHVNQAQVYEVVPCHSDCNQYL-WVTEPWSICKVTFVNMRENCGE 1120
R C P LD + + P H N W + PW C VT CG
Sbjct: 1090 TFPERRCRNIKKPNLD-LEETCNRRACPAHPVYNMVAGWYSLPWQQCTVT-------CGG 1141
Query: 1121 GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK---LPCPE 1164
GVQTR V C+Q S C + P R C P PE
Sbjct: 1142 GVQTRSVHCVQQGRPSSS-------CLLHQKPPVLRACNTNFCPAPE 1181
Score = 81.3 bits (199), Expect = 7e-15
Identities = 76/328 (23%), Positives = 130/328 (39%), Gaps = 62/328 (18%)
Query: 567 PCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPI--P 624
P + Y W V + + CG G + +C+ +V+ C P+ P
Sbjct: 869 PATKRPAYTWSIV-----QSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEP 923
Query: 625 VACDA-PCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIR--CPNSS 681
C+A CP + WST CS C+G + ++I+ + EE + CP S+
Sbjct: 924 KICNAFSCPAYWMPGEWST---CSKACAGGQ-QSRKIQCVQKKPFQKEEAVLHSLCPVST 979
Query: 682 ALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVR 741
Q V++CN H C W GPW QC + +C G++ R+++C
Sbjct: 980 PTQ-VQACNSHACPP-QWSLGPWSQCSK-----------------TCGRGVRKRELLCKG 1020
Query: 742 VNVGQVGPKKCPESLRPETVRPCLL-PCKKDC-IVTPYSDWTSCPSSC----KEGDSSIR 795
+ +C RPE C+L C K+ + S W+ C ++C ++ +
Sbjct: 1021 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
Query: 796 KQSRHRVIIQLPANGGRDCTDP-LYEEKACEAPQACQSY-------RWKTHKWRRCQLVP 847
++ +I P R+ P L E+ C +AC ++ W + W++C +
Sbjct: 1081 EKGFQGKLITFPERRCRNIKKPNLDLEETCNR-RACPAHPVYNMVAGWYSLPWQQCTVT- 1138
Query: 848 WSVQQDSPGAQEGCGPGRQARAITCRKQ 875
CG G Q R++ C +Q
Sbjct: 1139 -------------CGGGVQTRSVHCVQQ 1153
Score = 73.6 bits (179), Expect = 2e-12
Identities = 68/281 (24%), Positives = 114/281 (40%), Gaps = 44/281 (15%)
Query: 1117 NCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGS-RVCK-LPCPEDCVISEW--G 1172
+CG G K C+++ + V C + P+ ++C CP + W G
Sbjct: 888 SCGGGYINVKAICLRDQ----NTQVNSSFCSAKTKPVTEPKICNAFSCP-----AYWMPG 938
Query: 1173 PWTQCVLPCNQSSFRQRSADPIRQPADEGRS-----CPNAVEKEPCNLNKNCYHYDYNVT 1227
W+ C C ++ ++P + + CP + + N + +++
Sbjct: 939 EWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLG 998
Query: 1228 DWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMV-ECPVN 1286
WS C + CG G++ R L C S +++ C +L ++ C++ CP N
Sbjct: 999 PWSQCSKT----CGRGVRKRELLCKGSAAETLPESQCTSLPRP---ELQEGCVLGRCPKN 1051
Query: 1287 CQLSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQG-----DGRPCPSLMDQS------- 1332
+L W S WSECS TCGL + + + FQG R C ++ +
Sbjct: 1052 SRLQ-WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 1333 --KPCPVKPCYRWQYGQWS-PCQVQEAQCGEGTRTRNISCV 1370
+ CP P Y G +S P Q CG G +TR++ CV
Sbjct: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV 1151
Score = 69.7 bits (169), Expect = 2e-11
Identities = 81/322 (25%), Positives = 119/322 (36%), Gaps = 58/322 (18%)
Query: 1229 WSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQ 1288
WS Q CG G C+R V+ +C A + + CP
Sbjct: 878 WSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSA-KTKPVTEPKICNAFSCP---- 932
Query: 1289 LSDWSP--WSECSQTCGLTGKMIRRRTVTQ--PFQGDGRPCPSLMDQSKPCPVKPCY--- 1341
+ W P WS CS+ C G+ R+ Q PFQ + SL S P V+ C
Sbjct: 933 -AYWMPGEWSTCSKACA-GGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHA 990
Query: 1342 ---RWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGN 1398
+W G WS C CG G R R + C GSA ++ + E C +
Sbjct: 991 CPPQWSLGPWSQC---SKTCGRGVRKRELLC---KGSA---AETLPESQCTSL------- 1034
Query: 1399 KNMVLEESC-SQPCPGDCYLKDW--SSWSLCQLTCVNG--------EDLGFGGIQVRSRP 1447
L+E C CP + L+ W SSWS C TC G + GF G +
Sbjct: 1035 PRPELQEGCVLGRCPKNSRLQ-WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPE 1093
Query: 1448 VIIQELENQHLCPEQMLETKSCYDGQCYEY--KWMASAWKG---------SSRTVWCQRS 1496
+ ++ +L E+ ++C Y W + W+ +R+V C +
Sbjct: 1094 RRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ 1153
Query: 1497 DGINVTGGCLVMSQPDADRSCN 1518
+ CL+ +P R+CN
Sbjct: 1154 G--RPSSSCLLHQKPPVLRACN 1173
Score = 65.1 bits (157), Expect = 5e-10
Identities = 56/226 (24%), Positives = 86/226 (38%), Gaps = 44/226 (19%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGW----TTLHTNCKQAERPNNQQNCFKVCD 116
W G W C + GG Q+R + C + + LH+ C P + + C+
Sbjct: 935 WMPGEWSTC--SKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-----PVSTPTQVQACN 987
Query: 117 WHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEY 176
H W LGPW+QC + + K KG + E C
Sbjct: 988 SHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL------------- 1034
Query: 177 FEPKPLLEQACLI-PCQQDCIVS-EFSAWSECSKTCGSGLQHRTRHVVAPP------QFG 228
P+P L++ C++ C ++ + S+WSECS TCG G++ R F
Sbjct: 1035 --PRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFP 1092
Query: 229 GSGC-----PNLTEFQVCQSSPCEAEELRYSLHVG----PWSTCSM 265
C PNL + C C A + Y++ G PW C++
Sbjct: 1093 ERRCRNIKKPNLDLEETCNRRACPAHPV-YNMVAGWYSLPWQQCTV 1137
Score = 64.3 bits (155), Expect = 9e-10
Identities = 90/379 (23%), Positives = 121/379 (31%), Gaps = 125/379 (32%)
Query: 146 CIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSE 205
C++ ++ QV C K K + E IC F C + E WS
Sbjct: 900 CLR-DQNTQVNSSFCSAKTKPV-TEPKICNAFS------------CPAYWMPGE---WST 942
Query: 206 CSKTCGSGLQHRTRHVVAPPQFGG------SGCP--NLTEFQVCQSSPCEAEELRYSLHV 257
CSK C G Q R V F S CP T+ Q C S C + +SL
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ---WSL-- 997
Query: 258 GPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYW 317
GPWS CS R
Sbjct: 998 GPWSQCSKTCGR------------------------------------------------ 1009
Query: 318 DIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVS--EW--SEWSPCS 373
G + RE++C + S C P + CV+ + + S +W S WS CS
Sbjct: 1010 ----GVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECS 1065
Query: 374 KTCHDMVSPAGTRVRTRTIRQFPIG--------SEKEC-----PEFEEKEPCLSQGDGVV 420
TC G VR R ++ G E+ C P + +E C +
Sbjct: 1066 ATC-------GLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAH 1118
Query: 421 PCATY--GWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLS 478
P GW + W +C T CGGG+QTR V+CVQ S L
Sbjct: 1119 PVYNMVAGWYSLPWQQC----------------TVTCGGGVQTRSVHCVQQGRPSSSCL- 1161
Query: 479 THKNKEASKPMDLKLCTGP 497
H+ + + C P
Sbjct: 1162 LHQKPPVLRACNTNFCPAP 1180
Score = 56.2 bits (134), Expect = 3e-07
Identities = 34/96 (35%), Positives = 50/96 (52%), Gaps = 9/96 (9%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNLTE-FQVCQSSPCEAEELRYSL 255
S +S WSECS+TCG G++ + RH P PQ+GG CP + +Q+C +PC L +
Sbjct: 593 SAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRA 652
Query: 256 HVGPWSTCSMPHSRQVRQARRRGK--NKEREKDRSK 289
C+ +S+ R + K K E+DR K
Sbjct: 653 -----QQCAEYNSKPFRGWFYQWKPYTKVEEEDRCK 683
Score = 53.9 bits (128), Expect = 1e-06
Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 17/199 (8%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNC-FKVCDWHK 119
W GPW +C CG G ++ R + C T + C RP Q+ C C +
Sbjct: 995 WSLGPWSQC-SKTCGRG-VRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNS 1052
Query: 120 ELYDWRLGPWNQCQPVISKSLEK-PLECIKGEEGIQVREIACIQKD-KDIPAEDIICEYF 177
L W W++C + K ++C E+G Q + I ++ ++I ++ E
Sbjct: 1053 RL-QWVASSWSECSATCGLGVRKREMKC--SEKGFQGKLITFPERRCRNIKKPNLDLE-- 1107
Query: 178 EPKPLLEQACLIPCQQDCIVSEFSA-WSECSKTCGSGLQHRTRHVVAPPQFGGSGC---P 233
+ +AC + + +S W +C+ TCG G+Q R+ H V + S C
Sbjct: 1108 --ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGR-PSSSCLLHQ 1164
Query: 234 NLTEFQVCQSSPCEAEELR 252
+ C ++ C A E R
Sbjct: 1165 KPPVLRACNTNFCPAPEKR 1183
Score = 45.8 bits (107), Expect = 3e-04
Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 3/64 (4%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPKLDHVNQAQVYEVVP 1089
P P + S WS WS CS++CG GVK + + KP GG CP + Q+ + P
Sbjct: 585 PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRI--YQLCNINP 642
Query: 1090 CHSD 1093
C+ +
Sbjct: 643 CNEN 646
Score = 43.9 bits (102), Expect = 0.001
Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 638 STWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
S WS WS CS TC G G + + R + GG+ CP SS + ++ CN +PC
Sbjct: 593 SAWSKWSECSRTCGG----GVKFQERHCNNPKPQYGGLFCPGSSRIYQL--CNINPC 643
Score = 43.1 bits (100), Expect = 0.002
Identities = 22/57 (38%), Positives = 27/57 (47%)
Query: 1284 PVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
P++ Q S WS WSECS+TCG K R Q G CP + C + PC
Sbjct: 587 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
Score = 43.1 bits (100), Expect = 0.002
Identities = 68/301 (22%), Positives = 106/301 (35%), Gaps = 82/301 (27%)
Query: 422 CATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHK 481
C Y W EW+ C + C GG Q+R++ CVQ + H
Sbjct: 931 CPAY-WMPGEWSTC----------------SKACAGGQQSRKIQCVQKKPFQKEEAVLH- 972
Query: 482 NKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKL 540
LC P Q C+ CP + + PWS C+ G+ +
Sbjct: 973 ----------SLCPVSTPTQVQACNSHACPPQWSLGPWS--------QCSKTCGR---GV 1011
Query: 541 RKRRITNEPTGGSGV-TGNC-----PHLLEAI---PCEEPACYDWKAVRLGNCEPDNGKE 591
RKR + + + + C P L E C + + W A C
Sbjct: 1012 RKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSEC----SAT 1067
Query: 592 CGPGTQVQEVVCINSDGE----EVDRQLCRDAIFP---IPVACD-APCPKDCV---LSTW 640
CG G + +E+ C + + CR+ P + C+ CP V ++ W
Sbjct: 1068 CGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGW 1127
Query: 641 ST--WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQE-----VRSCNEHP 693
+ W C+ TC G G Q R+ + ++G P+SS L +R+CN +
Sbjct: 1128 YSLPWQQCTVTCGG----GVQTRS----VHCVQQGR---PSSSCLLHQKPPVLRACNTNF 1176
Query: 694 C 694
C
Sbjct: 1177 C 1177
Score = 37.7 bits (86), Expect = 0.093
Identities = 68/318 (21%), Positives = 105/318 (33%), Gaps = 93/318 (29%)
Query: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHDM 379
GY + +C+ + SFC + P+T C + W EWS CSK C
Sbjct: 892 GYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP-AYWMPGEWSTCSKAC--- 947
Query: 380 VSPAGTRVR-TRTIRQFPIGSEKE-----CPEFEEKEPCLSQGDGVVPCATYG----WRT 429
G + R + +++ P E+ CP +S V C ++ W
Sbjct: 948 --AGGQQSRKIQCVQKKPFQKEEAVLHSLCP--------VSTPTQVQACNSHACPPQWSL 997
Query: 430 TEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPM 489
W++C + CG G++ RE+ C A++ +
Sbjct: 998 GPWSQC----------------SKTCGRGVRKRELLC---------------KGSAAETL 1026
Query: 490 DLKLCTG-PIPNTTQLCHI-PCPTECEVSPW--SAWGPCTYENCNDQQGKKGFKLRKRRI 545
CT P P + C + CP + W S+W C+ C G +RKR +
Sbjct: 1027 PESQCTSLPRPELQEGCVLGRCPKNSRLQ-WVASSWSECS-ATC-------GLGVRKREM 1077
Query: 546 TNEPTGGSG-----VTGNC-----PHLLEAIPCEEPAC---------YDWKAVRLGNCEP 586
G G C P+L C AC W ++ C
Sbjct: 1078 KCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCT- 1136
Query: 587 DNGKECGPGTQVQEVVCI 604
CG G Q + V C+
Sbjct: 1137 ---VTCGGGVQTRSVHCV 1151
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 85.1 bits (209), Expect = 5e-16
Identities = 82/270 (30%), Positives = 109/270 (40%), Gaps = 53/270 (19%)
Query: 19 RRGVLQLL----PLPLPLPLLLLLLLRPGAG-----------RAAAQGEAEAP--TLYLW 61
RRG+ + + P LPL L++LL G A Q E E P +L++W
Sbjct: 745 RRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIW 804
Query: 62 KTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTN---CKQAERPNNQQNCFKVCDWH 118
W C +CG GG + V C + TT N C QA RP Q + C+ H
Sbjct: 805 THSGWEGC-SVQCG-GGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQ---VRRCNLH 859
Query: 119 KELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACI---QKDKDIPAEDIICE 175
W GPW+ C E+G Q RE+ C+ Q + + C
Sbjct: 860 PCQSRWVAGPWSPCSATC-------------EKGFQHREVTCVYQLQNGTHVATRPLYCP 906
Query: 176 YFEPKPLLEQACLIPCQQDCI-VSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPN 234
P+P Q+C QDC+ + E S WS+CS +CG G+ RT VA G C
Sbjct: 907 --GPRPAAVQSCE---GQDCLSIWEASEWSQCSASCGKGVWKRT---VACTNSQGK-CDA 957
Query: 235 LTEFQVCQSSPCEAEELRYSLHVGPWSTCS 264
T + CE Y G WSTCS
Sbjct: 958 STRPRA--EEACEDYSGCYEWKTGDWSTCS 985
Score = 84.3 bits (207), Expect = 9e-16
Identities = 79/281 (28%), Positives = 107/281 (38%), Gaps = 54/281 (19%)
Query: 632 PKDCV-LSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQ-EVRSC 689
P+D + + T S W CS C G R + CP +S + +VR C
Sbjct: 797 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRC 856
Query: 690 NEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICV-RVNVGQ-- 746
N HPC W GPW C A+C G Q R+V CV ++ G
Sbjct: 857 NLHPCQS-RWVAGPWSPC-----------------SATCEKGFQHREVTCVYQLQNGTHV 898
Query: 747 -VGPKKCPESLRPETVRPCLLPCKKDCI-VTPYSDWTSCPSSCKEGDSSIRKQSRHRVII 804
P CP RP V+ C +DC+ + S+W+ C +SC +G R +
Sbjct: 899 ATRPLYCPGP-RPAAVQSCE---GQDCLSIWEASEWSQCSASCGKGVWK-------RTVA 947
Query: 805 QLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPG 864
+ G D + E+ACE C Y WKT W C CG G
Sbjct: 948 CTNSQGKCDASTRPRAEEACEDYSGC--YEWKTGDWSTCSST--------------CGKG 991
Query: 865 RQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQD 905
Q+R + C + G+ G EC + P P Q Q C D
Sbjct: 992 LQSRVVQCMHKVTGRHG-SECPALSKPAP-YRQCYQEVCND 1030
Score = 62.4 bits (150), Expect = 4e-09
Identities = 72/270 (26%), Positives = 100/270 (37%), Gaps = 64/270 (23%)
Query: 881 GIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCGAVRTRKRTLVGKSKK 938
GIH +Y PV + P + L W S + C+ CG +RT+V ++
Sbjct: 775 GIH--YEYTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGG--GERRTIVSCTRI 830
Query: 939 KEKCKNSHLYPLIETQYCP-----------CDKYNAQP---VGNWSDCILPEGKVEVLLG 984
K L+ CP C+ + Q G WS C
Sbjct: 831 VNKTTT-----LVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSAT--------- 876
Query: 985 MKVQGDIKECGQGYRYQAMACYDQ--NGRLVETSRCNSHGYIEEACIIPCPSDCKLSEW- 1041
C +G++++ + C Q NG V T G A + C LS W
Sbjct: 877 ---------CEKGFQHREVTCVYQLQNGTHVATRPLYCPGP-RPAAVQSCEGQDCLSIWE 926
Query: 1042 -SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWV 1100
S WS+CS SCG GV W R + K D + + E +S C Y W
Sbjct: 927 ASEWSQCSASCGKGV-----WKRTVACTNSQ--GKCDASTRPRAEEACEDYSGC--YEWK 977
Query: 1101 TEPWSICKVTFVNMRENCGEGVQTRKVRCM 1130
T WS C T CG+G+Q+R V+CM
Sbjct: 978 TGDWSTCSST-------CGKGLQSRVVQCM 1000
Score = 62.4 bits (150), Expect = 4e-09
Identities = 74/279 (26%), Positives = 104/279 (37%), Gaps = 52/279 (18%)
Query: 1079 VNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPS 1138
VN+ + P + ++W W C V CG G + V C + + +
Sbjct: 784 VNRTAENQSEPEKPQDSLFIWTHSGWEGCSV-------QCGGGERRTIVSCTR-IVNKTT 835
Query: 1139 EHVEDYLCDPEEMPLGS-RVCKL-PCPEDCVISEW--GPWTQCVLPCNQSSFRQRSADPI 1194
V D C P R C L PC S W GPW+ C C + F+ R +
Sbjct: 836 TLVNDSDCPQASRPEPQVRRCNLHPCQ-----SRWVAGPWSPCSATC-EKGFQHREVTCV 889
Query: 1195 RQ------PADEGRSCPNA--VEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKT 1246
Q A CP + C ++C + ++WS C S CG G+
Sbjct: 890 YQLQNGTHVATRPLYCPGPRPAAVQSCE-GQDCLSI-WEASEWSQCSAS----CGKGVWK 943
Query: 1247 RMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTG 1306
R + C S GK C+A + +C E C WS CS TCG
Sbjct: 944 RTVACTNSQGK------CDA---STRPRAEEAC--EDYSGCYEWKTGDWSTCSSTCG--- 989
Query: 1307 KMIRRRTVTQPFQGDGR---PCPSLMDQSKPCPVKPCYR 1342
K ++ R V + GR CP+L SKP P + CY+
Sbjct: 990 KGLQSRVVQCMHKVTGRHGSECPAL---SKPAPYRQCYQ 1025
Score = 57.4 bits (137), Expect = 1e-07
Identities = 56/221 (25%), Positives = 75/221 (33%), Gaps = 54/221 (24%)
Query: 1229 WSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQ 1288
W C + CG G + ++ C R K+ L + C ++
Sbjct: 809 WEGCSVQ----CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVR---RCNLHPC 861
Query: 1289 LSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQGDG------RP--CPSLMDQSKPCPVK 1338
S W PWS CS TC K + R VT +Q RP CP +P V+
Sbjct: 862 QSRWVAGPWSPCSATCE---KGFQHREVTCVYQLQNGTHVATRPLYCPG----PRPAAVQ 914
Query: 1339 PCYR------WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIE 1392
C W+ +WS C A CG+G R ++C S G D ++ EE C D
Sbjct: 915 SCEGQDCLSIWEASEWSQCS---ASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDY- 970
Query: 1393 LIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNG 1433
CY WS C TC G
Sbjct: 971 --------------------SGCYEWKTGDWSTCSSTCGKG 991
Score = 52.8 bits (125), Expect = 3e-06
Identities = 62/248 (25%), Positives = 86/248 (34%), Gaps = 43/248 (17%)
Query: 455 CGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECE 514
CGGG + V C + + ++ +AS+P P + PC +
Sbjct: 816 CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE---------PQVRRCNLHPCQSRWV 866
Query: 515 VSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGN---CPHLLEAI--PCE 569
PWS PC+ C +KGF+ R+ + G+ V CP A CE
Sbjct: 867 AGPWS---PCS-ATC-----EKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCE 917
Query: 570 EPACYD-WKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACD 628
C W+A C CG G + V C NS G+ C + P +
Sbjct: 918 GQDCLSIWEASEWSQCSAS----CGKGVWKRTVACTNSQGK------CDASTRP---RAE 964
Query: 629 APCPKDCVLSTWST--WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEV 686
C W T WS+CS TC +G Q R + G CP S
Sbjct: 965 EACEDYSGCYEWKTGDWSTCSSTC----GKGLQSRVVQCMHKVTGRHGSECPALSKPAPY 1020
Query: 687 RSCNEHPC 694
R C + C
Sbjct: 1021 RQCYQEVC 1028
Score = 52.0 bits (123), Expect = 5e-06
Identities = 58/225 (25%), Positives = 75/225 (33%), Gaps = 49/225 (21%)
Query: 591 ECGPGTQVQEVVC---INSDGEEVDRQLCRDAIFPIPVA--CDA-PCPKDCVLSTWSTWS 644
+CG G + V C +N V+ C A P P C+ PC V WS
Sbjct: 815 QCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSP-- 872
Query: 645 SCSHTCSGKTTEGKQIRARSILAYAGEEGG-------IRCPNSSALQEVRSCNEHPCTVY 697
CS TC K + R + + G + CP V+SC C
Sbjct: 873 -CSATCE------KGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAA-VQSCEGQDCLSI 924
Query: 698 HWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLR 757
W+ W QC ASC G+ R V C KC S R
Sbjct: 925 -WEASEWSQC-----------------SASCGKGVWKRTVACTN------SQGKCDASTR 960
Query: 758 PETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRV 802
P C C DW++C S+C +G S Q H+V
Sbjct: 961 PRAEEAC--EDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKV 1003
Score = 47.8 bits (112), Expect = 9e-05
Identities = 26/60 (43%), Positives = 34/60 (56%), Gaps = 2/60 (3%)
Query: 189 IPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQF-GGSGCPNLT-EFQVCQSSPC 246
IP D S + AWS CS+TCG+G + R R PP GG+ CP + E VC++ PC
Sbjct: 538 IPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPC 597
Score = 45.8 bits (107), Expect = 3e-04
Identities = 40/150 (26%), Positives = 57/150 (38%), Gaps = 33/150 (22%)
Query: 322 GYQTREVMCI----NKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCH 377
G+Q REV C+ N T A +C + P QSC + E SEWS CS +C
Sbjct: 880 GFQHREVTCVYQLQNGTHVATRPLYCPGPR-PAAVQSCEGQDCLSIWEASEWSQCSASC- 937
Query: 378 DMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRV 437
G V RT+ + + E G Y W+T +W+ C
Sbjct: 938 ------GKGVWKRTVACTNSQGKCDASTRPRAEEACEDYSG-----CYEWKTGDWSTC-- 984
Query: 438 DPLLSQQDKRRGNQTALCGGGIQTREVYCV 467
++ CG G+Q+R V C+
Sbjct: 985 --------------SSTCGKGLQSRVVQCM 1000
Score = 41.6 bits (96), Expect = 0.006
Identities = 26/73 (35%), Positives = 33/73 (45%), Gaps = 6/73 (8%)
Query: 1273 WQMNTSCMVECPVNCQLS-DWSPW---SECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPS 1327
W C+ + P+ + DWSPW S CS+TCG TG R+R P G G CP
Sbjct: 526 WCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCG-TGARFRQRKCDNPPPGPGGTHCPG 584
Query: 1328 LMDQSKPCPVKPC 1340
+ C PC
Sbjct: 585 ASVEHAVCENLPC 597
Score = 41.6 bits (96), Expect = 0.006
Identities = 62/260 (23%), Positives = 87/260 (33%), Gaps = 75/260 (28%)
Query: 331 INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTC-----HDMVS-- 381
+NKT + S C Q P CQ S W WSPCS TC H V+
Sbjct: 831 VNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ-SRWVAGPWSPCSATCEKGFQHREVTCV 889
Query: 382 ---PAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVD 438
GT V TR + + G + E + CLS W +EW++C
Sbjct: 890 YQLQNGTHVATRPL--YCPGPRPAAVQSCEGQDCLSI-----------WEASEWSQC--- 933
Query: 439 PLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPI 498
+A CG G+ R V C S K +++P + C
Sbjct: 934 -------------SASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACE--- 968
Query: 499 PNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGN 558
+ S W + C+ G KG + R + ++ TG G
Sbjct: 969 ---------------DYSGCYEWKTGDWSTCSSTCG-KGLQSRVVQCMHKVTGRHG--SE 1010
Query: 559 CPHLLEAIP---CEEPACYD 575
CP L + P C + C D
Sbjct: 1011 CPALSKPAPYRQCYQEVCND 1030
Score = 40.8 bits (94), Expect = 0.011
Identities = 42/121 (34%), Positives = 50/121 (41%), Gaps = 11/121 (9%)
Query: 1154 GSRVCKLPCPE--DCVISEWGPWTQCVLPCNQSS-FRQRSADPIRQPADEGRSCPNA-VE 1209
G V K P PE D S WG W+ C C + FRQR D P G CP A VE
Sbjct: 530 GECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN-PPPGPGGTHCPGASVE 588
Query: 1210 KEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGL 1269
C N C + D CQ ++ + K +L V D K +L YC LG
Sbjct: 589 HAVCE-NLPCPKGLPSFRD-QQCQAHDRL---SPKKKGLLTAVVVDDKPCEL-YCSPLGK 642
Query: 1270 E 1270
E
Sbjct: 643 E 643
Score = 38.9 bits (89), Expect = 0.042
Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 7/64 (10%)
Query: 1030 IPCPSDCKLSEWSNWSRCSKSCGSGVKVRS-KWLREKPYNGGRPCP--KLDHVNQAQVYE 1086
IP D S W WS CS++CG+G + R K P GG CP ++H V E
Sbjct: 538 IPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHA----VCE 593
Query: 1087 VVPC 1090
+PC
Sbjct: 594 NLPC 597
Score = 36.6 bits (83), Expect = 0.21
Identities = 30/109 (27%), Positives = 36/109 (33%), Gaps = 26/109 (23%)
Query: 586 PDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSS 645
P +G ECG + C++ PIP D S W WS
Sbjct: 515 PLDGTECGADKWCRAGECVSKT--------------PIPEHVDGDW------SPWGAWSM 554
Query: 646 CSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
CS TC G + R R GG CP +S V C PC
Sbjct: 555 CSRTCG----TGARFRQRKCDNPPPGPGGTHCPGASVEHAV--CENLPC 597
Score = 33.5 bits (75), Expect = 1.8
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 9/68 (13%)
Query: 507 IPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHL-LEA 565
IP + + SPW AW C+ C G + R+R+ N P G G +CP +E
Sbjct: 538 IPEHVDGDWSPWGAWSMCS-RTCG-----TGARFRQRKCDNPPPGPGGT--HCPGASVEH 589
Query: 566 IPCEEPAC 573
CE C
Sbjct: 590 AVCENLPC 597
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 84.7 bits (208), Expect = 7e-16
Identities = 64/212 (30%), Positives = 86/212 (40%), Gaps = 40/212 (18%)
Query: 1227 TDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVN 1286
+ WSTC ++ CG G + R CV G +C E NT+ CPV+
Sbjct: 298 SQWSTCSVT----CGQGSQVRTRTCVSPYGT-----HCSGPLRESRVCNNTAL---CPVH 345
Query: 1287 CQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC---YRW 1343
+WSPWS CS TCG G+ R R+ T P G GRPC KPC + C +W
Sbjct: 346 GVWEEWSPWSLCSFTCG-RGQRTRTRSCTPPQYG-GRPCEGPETHHKPCNIALCPVDGQW 403
Query: 1344 Q-YGQWSPCQVQEAQCGEGTRTRNISC-VVSDGSADDFSKVVDEEFCADIELIIDGNKNM 1401
Q + WS C V C GT+ R+ C + G ++ + C + E +G N
Sbjct: 404 QEWSSWSQCSV---TCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWN- 459
Query: 1402 VLEESCSQPCPGDCYLKDWSSWSLCQLTCVNG 1433
W WS C +C G
Sbjct: 460 -----------------QWGHWSGCSKSCDGG 474
Score = 79.0 bits (193), Expect = 4e-14
Identities = 69/256 (26%), Positives = 95/256 (37%), Gaps = 47/256 (18%)
Query: 1289 LSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKP------CPVKPCYR 1342
+ +WS WS CS TCG G +R RT P+ G C + +S+ CPV +
Sbjct: 294 VEEWSQWSTCSVTCG-QGSQVRTRTCVSPY---GTHCSGPLRESRVCNNTALCPVHGVWE 349
Query: 1343 WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMV 1402
+WSP + CG G RTR SC +I L
Sbjct: 350 ----EWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIAL--------- 396
Query: 1403 LEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQ 1462
CP D ++WSSWS C +TC N G Q RSR C
Sbjct: 397 --------CPVDGQWQEWSSWSQCSVTCSN-------GTQQRSRQCTAAAHGGSE-CRGP 440
Query: 1463 MLETKSCYDGQC-YEYKW-MASAWKGSSRTV---WCQR---SDGINVTGGCLVMSQPDAD 1514
E++ CY+ +C +W W G S++ W +R G +TG + +
Sbjct: 441 WAESRECYNPECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVR 500
Query: 1515 RSCNPPCSQPHSYCSE 1530
R C P+ C E
Sbjct: 501 RCSEQRCPAPYEICPE 516
Score = 70.1 bits (170), Expect = 2e-11
Identities = 70/266 (26%), Positives = 102/266 (38%), Gaps = 64/266 (24%)
Query: 640 WSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYH- 698
WS WS+CS TC +G Q+R R+ ++ G C S L+E R CN H
Sbjct: 297 WSQWSTCSVTCG----QGSQVRTRTCVS----PYGTHC--SGPLRESRVCNNTALCPVHG 346
Query: 699 -WQT-GPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESL 756
W+ PW C SF +C G +TR C Q G + C
Sbjct: 347 VWEEWSPWSLC-------SF----------TCGRGQRTRTRSCTPP---QYGGRPCEG-- 384
Query: 757 RPETV-RPCLLP-CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDC 814
PET +PC + C D +S W+ C +C G +Q A+GG +C
Sbjct: 385 -PETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCT------AAAHGGSEC 437
Query: 815 TDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITC-- 872
P E + C P+ + +W ++W WS G + C G + R TC
Sbjct: 438 RGPWAESRECYNPECTANGQW--NQWGH-----WS------GCSKSCDGGWERRIRTCQG 484
Query: 873 -----RKQDGGQAGIHECLQYAGPVP 893
++ +G + C + P P
Sbjct: 485 AVITGQQCEGTGEEVRRCSEQRCPAP 510
Score = 69.3 bits (168), Expect = 3e-11
Identities = 66/248 (26%), Positives = 90/248 (36%), Gaps = 58/248 (23%)
Query: 1038 LSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQY 1097
+ EWS WS CS +CG G +VR++ PY G L + P H ++
Sbjct: 294 VEEWSQWSTCSVTCGQGSQVRTRTC-VSPY-GTHCSGPLRESRVCNNTALCPVHGVWEEW 351
Query: 1098 LWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQ-----NTADGPSEHVEDYLCDPEEMP 1152
PWS+C T CG G +TR C +GP H
Sbjct: 352 ----SPWSLCSFT-------CGRGQRTRTRSCTPPQYGGRPCEGPETH------------ 388
Query: 1153 LGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRS---------ADPIRQPADEGR 1202
+ C + CP D EW W+QC + C+ + +QRS R P E R
Sbjct: 389 --HKPCNIALCPVDGQWQEWSSWSQCSVTCSNGT-QQRSRQCTAAAHGGSECRGPWAESR 445
Query: 1203 SCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLK 1262
C N C N + + WS C S C G + R+ C G + +
Sbjct: 446 ECYN----PECTANGQWNQWGH----WSGCSKS----CDGGWERRIRTC---QGAVITGQ 490
Query: 1263 YCEALGLE 1270
CE G E
Sbjct: 491 QCEGTGEE 498
Score = 55.5 bits (132), Expect = 4e-07
Identities = 83/354 (23%), Positives = 119/354 (33%), Gaps = 79/354 (22%)
Query: 358 TKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGD 417
T E V EWS+WS CS TC G++VRTRT P G+ P E C +
Sbjct: 289 TGESGVEEWSQWSTCSVTCGQ-----GSQVRTRTCVS-PYGTHCSGP-LRESRVC----N 337
Query: 418 GVVPCATYG-WRT-TEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLS 475
C +G W + W+ C + CG G +TR C
Sbjct: 338 NTALCPVHGVWEEWSPWSLC----------------SFTCGRGQRTRTRSCTPP------ 375
Query: 476 QLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGK 535
+ +P C GP + CP + + WS+W C+ N
Sbjct: 376 -------QYGGRP-----CEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSN----- 418
Query: 536 KGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPG 595
G + R R+ T GGS G E+ C P C K C G
Sbjct: 419 -GTQQRSRQCTAAAHGGSECRG---PWAESRECYNPECTANGQWNQWGHWSGCSKSCDGG 474
Query: 596 TQVQEVVC---------INSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLS-TWS---- 641
+ + C GEEV R C + P P CP+D ++S W
Sbjct: 475 WERRIRTCQGAVITGQQCEGTGEEVRR--CSEQRCPAPYEI---CPEDYLMSMVWKRTPA 529
Query: 642 ---TWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEH 692
++ C +G T+ + + A+ + RC ++ S EH
Sbjct: 530 GDLAFNQCPLNATGTTSRRCSLSLHGV-AFWEQPSFARCISNEYRHLQHSIKEH 582
Score = 52.0 bits (123), Expect = 5e-06
Identities = 66/277 (23%), Positives = 105/277 (37%), Gaps = 71/277 (25%)
Query: 912 WSKFSSCNGDCG-AVRTRKRTLV--------GKSKKKEKCKNSHLYPL--IETQYCPCDK 960
WS++S+C+ CG + R RT V G ++ C N+ L P+ + ++ P
Sbjct: 297 WSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSP--- 353
Query: 961 YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACY--DQNGRLVETSRC 1018
WS C CG+G R + +C GR E
Sbjct: 354 --------WSLCSFT------------------CGRGQRTRTRSCTPPQYGGRPCEGPET 387
Query: 1019 NSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDH 1078
+ + I CP D + EWS+WS+CS +C +G + RS+ + GG C +
Sbjct: 388 HH----KPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAH-GGSEC-RGPW 441
Query: 1079 VNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNT----- 1133
+ Y C ++ W WS C ++C +G R++R Q
Sbjct: 442 AESRECYN-PECTANGQWNQW--GHWSGCS-------KSC-DGGWERRIRTCQGAVITGQ 490
Query: 1134 -ADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVIS 1169
+G E V C + P + CPED ++S
Sbjct: 491 QCEGTGEEVR--RCSEQRCPAPYEI----CPEDYLMS 521
Score = 50.8 bits (120), Expect = 1e-05
Identities = 68/281 (24%), Positives = 102/281 (36%), Gaps = 68/281 (24%)
Query: 774 VTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSY 833
V +S W++C +C +G Q R R + + G C+ PL E + C C +
Sbjct: 294 VEEWSQWSTCSVTCGQGS-----QVRTRTCV---SPYGTHCSGPLRESRVCNNTALCPVH 345
Query: 834 R-WKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPV 892
W+ +W PWS+ + CG G++ R +C Q G C GP
Sbjct: 346 GVWE--EWS-----PWSLCSFT------CGRGQRTRTRSCTPP---QYGGRPC---EGP- 385
Query: 893 PALTQACQIP-CQDDCQLTSWSKFSSCNGDC-GAVRTRKRTLVGKSKKKEKCKNSHLYPL 950
+ C I C D Q WS +S C+ C + R R + +C+ P
Sbjct: 386 ETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRG----PW 441
Query: 951 IETQYC--PCDKYNAQ--PVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACY 1006
E++ C P N Q G+WS C K C G+ + C
Sbjct: 442 AESRECYNPECTANGQWNQWGHWSGC------------------SKSCDGGWERRIRTC- 482
Query: 1007 DQNGRLVETSRCNSHG-----YIEEACIIP---CPSDCKLS 1039
G ++ +C G E+ C P CP D +S
Sbjct: 483 --QGAVITGQQCEGTGEEVRRCSEQRCPAPYEICPEDYLMS 521
Score = 49.3 bits (116), Expect = 3e-05
Identities = 61/231 (26%), Positives = 85/231 (36%), Gaps = 31/231 (13%)
Query: 197 VSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS---PCEAEELRY 253
V E+S WS CS TCG G Q RTR V+P +G L E +VC ++ P +
Sbjct: 294 VEEWSQWSTCSVTCGQGSQVRTRTCVSP--YGTHCSGPLRESRVCNNTALCPVHGVWEEW 351
Query: 254 SLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQE 313
S PWS CS R R R ++ + + + PE + N
Sbjct: 352 S----PWSLCSFTCG---RGQRTRTRSCTPPQYGGRPCEGPETHH-----KPCNIALCPV 399
Query: 314 NKYWDIQIGYQTREVMCINKTGK-----AADLSFCQQEKLPMTFQSCVITKEC----QVS 364
+ W + V C N T + A + + P EC Q +
Sbjct: 400 DGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWN 459
Query: 365 EWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQ 415
+W WS CSK+C G R RT + I ++ EE C Q
Sbjct: 460 QWGHWSGCSKSC-----DGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQ 505
Score = 47.8 bits (112), Expect = 9e-05
Identities = 66/257 (25%), Positives = 80/257 (31%), Gaps = 100/257 (38%)
Query: 455 CGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP--CPTE 512
CG G Q R CV S TH C+GP+ +++C+ CP
Sbjct: 307 CGQGSQVRTRTCV-------SPYGTH-------------CSGPL-RESRVCNNTALCPVH 345
Query: 513 CEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPA 572
WS W C++ C +G + R R T GG PCE P
Sbjct: 346 GVWEEWSPWSLCSF-TCG-----RGQRTRTRSCTPPQYGGR-------------PCEGP- 385
Query: 573 CYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCP 632
E + C A+ CP
Sbjct: 386 -------------------------------------ETHHKPCNIAL----------CP 398
Query: 633 KDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEH 692
D WS+WS CS TCS G Q R+R A A GG C A E R C
Sbjct: 399 VDGQWQEWSSWSQCSVTCS----NGTQQRSRQCTAAA--HGGSECRGPWA--ESRECYNP 450
Query: 693 PCTVY-HW-QTGPWGQC 707
CT W Q G W C
Sbjct: 451 ECTANGQWNQWGHWSGC 467
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/178 (25%), Positives = 68/178 (38%), Gaps = 18/178 (10%)
Query: 191 CQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPN-LTEFQVCQSSPCEAE 249
C + E+S WS CS TCG G + RTR PPQ+GG C T + C + C +
Sbjct: 342 CPVHGVWEEWSPWSLCSFTCGRGQRTRTRS-CTPPQYGGRPCEGPETHHKPCNIALCPVD 400
Query: 250 ELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQ 309
WS CS+ S +Q R+ +G E+RE + N Q
Sbjct: 401 GQWQEW--SSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRG-PWAESRECYNPECTANGQ 457
Query: 310 NRQENKYW-----DIQIGYQTREVMCINKT-------GKAADLSFCQQEKLPMTFQSC 355
Q +W G++ R C G ++ C +++ P ++ C
Sbjct: 458 WNQWG-HWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRCPAPYEIC 514
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 84.3 bits (207), Expect = 9e-16
Identities = 103/407 (25%), Positives = 139/407 (34%), Gaps = 96/407 (23%)
Query: 1029 IIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSK-WLREKPYNGGRPCPKLDHVNQAQVYEV 1087
I C + + WS+W+ CS SCG G +VR + P +GGR C + E
Sbjct: 658 IANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSR-EERFCNEN 716
Query: 1088 VPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCD 1147
PC W + WS C NCG G+Q+R+ C +N VE C+
Sbjct: 717 TPCPVPIFWASWGS--WSKCS-------SNCGGGMQSRRRAC-ENGNSCLGCGVEFKTCN 766
Query: 1148 PEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA 1207
PE CPE + W PW LP N + R R + P+
Sbjct: 767 PE-----------GCPEVRRNTPWTPW----LPVNVTQGGARQEQRFRFTCRAPLADPHG 811
Query: 1208 VEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEAL 1267
++ + T+ TC C +L +RS S
Sbjct: 812 LQ------------FGRRRTETRTCPADGSGSCDTDALVEVL--LRSGSTSPHT------ 851
Query: 1268 GLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPF-QGDGRPCP 1326
+ W + W PWS CS+ C L G +R+RT T P + G PC
Sbjct: 852 -VSGGW----------------AAWGPWSSCSRDCEL-GFRVRKRTCTNPEPRNGGLPCV 893
Query: 1327 SLMDQSKPCPVKPC---YRWQ-YGQWSPCQVQEAQCGEGTRTRNISC---VVSDGSADDF 1379
+ + C + C W + WSPC A CG G R SC S G
Sbjct: 894 GDAAEYQDCNPQACPVRGAWSCWTSWSPC---SASCGGGHYQRTRSCTSPAPSPGEDICL 950
Query: 1380 SKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLC 1426
+E CA +Q CP WS WS C
Sbjct: 951 GLHTEEALCA------------------TQACPEG--WSPWSEWSKC 977
Score = 61.6 bits (148), Expect = 6e-09
Identities = 102/471 (21%), Positives = 139/471 (29%), Gaps = 110/471 (23%)
Query: 517 PWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDW 576
PWS W PC + + D G + R GG G H+ A W
Sbjct: 614 PWSPWQPCEHLD-GDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANC--SRNGAWTPW 670
Query: 577 KAVRLGNCEPDNGKECGPGTQVQEVVCINSD---------GEEVDRQLCRDAIFPIPVAC 627
+ L + CG G QV++ C N G+ + + C +
Sbjct: 671 SSWALCSTS------CGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNE--------- 715
Query: 628 DAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVR 687
+ PCP ++W +WS CS C G G Q R R+ E G C E +
Sbjct: 716 NTPCPVPIFWASWGSWSKCSSNCGG----GMQSRRRAC------ENGNSCLGCGV--EFK 763
Query: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
+CN C T PW T W G + +
Sbjct: 764 TCNPEGCPEVRRNT-PW---------------TPWLPVNVTQGGARQEQRFRFTCRAPLA 807
Query: 748 GPKKCPESLRPETVRPCLL----PCKKDCIV------------------TPYSDWTSCPS 785
P R R C C D +V + W+SC
Sbjct: 808 DPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSR 867
Query: 786 SCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQL 845
C+ G +RK++ P NGG C E + C PQAC
Sbjct: 868 DCELG-FRVRKRT---CTNPEPRNGGLPCVGDAAEYQDCN-PQACPVRG----------- 911
Query: 846 VPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECL-QYAGPVPALTQACQIPCQ 904
WS CG G R +C G CL + TQAC
Sbjct: 912 -AWSCWTSWSPCSASCGGGHYQRTRSC-TSPAPSPGEDICLGLHTEEALCATQACPE--- 966
Query: 905 DDCQLTSWSKFSSCNGDCGAVRTR--------KRTLVGKSKKKEKCKNSHL 947
+ WS++S C D R+R G S + C S +
Sbjct: 967 ---GWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEI 1014
Score = 57.8 bits (138), Expect = 9e-08
Identities = 113/483 (23%), Positives = 152/483 (31%), Gaps = 121/483 (25%)
Query: 633 KDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEH 692
+D WS W C H G + RARS + GG+ C + + +C+ +
Sbjct: 608 RDGGFGPWSPWQPCEHL-DGDNSGSCLCRARSCDSPRPRCGGLDCLGPAI--HIANCSRN 664
Query: 693 PCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKC 752
G W T SS+ +T SC +G Q R+ C + G + C
Sbjct: 665 ---------GAW------TPWSSWALCST-----SCGIGFQVRQRSCSNP-APRHGGRIC 703
Query: 753 PESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGR 812
R E PC + W+ C S+C G QSR R G
Sbjct: 704 VGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGG-----MQSRRRA-----CENGN 753
Query: 813 DCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPW-SVQQDSPGAQEGCGPGRQARAIT 871
C E K C P+ C R T W PW V GA++ Q T
Sbjct: 754 SCLGCGVEFKTCN-PEGCPEVRRNT-PW-----TPWLPVNVTQGGARQ-----EQRFRFT 801
Query: 872 CRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQL---------------------- 909
CR G LQ+ G T+ C C
Sbjct: 802 CRAPLADPHG----LQF-GRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGW 856
Query: 910 TSWSKFSSCNGDCG-AVRTRKRTLVGKSKKKEKCKNSHLYPLI--ETQYCPCDKYNAQPV 966
+W +SSC+ DC R RKRT + N L P + +Y C+
Sbjct: 857 AAWGPWSSCSRDCELGFRVRKRTCTNPEPR-----NGGL-PCVGDAAEYQDCNPQACPVR 910
Query: 967 GNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEE 1026
G WS C CG G+ + +C TS S G E+
Sbjct: 911 GAWS-CWTSWSPCSA-----------SCGGGHYQRTRSC---------TSPAPSPG--ED 947
Query: 1027 ACI------IPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLRE---------KPYNGGR 1071
C+ C + WS WS SK G + RS+ E + R
Sbjct: 948 ICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSR 1007
Query: 1072 PCP 1074
PCP
Sbjct: 1008 PCP 1010
Score = 56.2 bits (134), Expect = 3e-07
Identities = 121/548 (22%), Positives = 167/548 (30%), Gaps = 119/548 (21%)
Query: 65 PWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQ----QNCFKVCDWHKE 120
P RC + R +C GW C E +N QN C
Sbjct: 552 PLERCAAYRSQGACLGARDPYC----GWDGKQQRCSTLEDSSNMSLWTQN-ITACPVRNV 606
Query: 121 LYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPK 180
D GPW+ QP + C+ C D PA I
Sbjct: 607 TRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIA------- 659
Query: 181 PLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNLT-EF 238
C ++ + +S+W+ CS +CG G Q R R P P+ GG C + E
Sbjct: 660 ---------NCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREE 710
Query: 239 QVC-QSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEAR 297
+ C +++PC S G WS CS ++ RR +N K
Sbjct: 711 RFCNENTPCPVPIFWASW--GSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPE 768
Query: 298 ELIKKKRN-----------RNRQNRQENKY-----------WDIQIGYQTREVMCINKTG 335
+ +RN RQE ++ +Q G + E G
Sbjct: 769 GCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADG 828
Query: 336 KAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTI--- 392
+ + E L + + T + W WS CS+ C G RVR RT
Sbjct: 829 SGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCE-----LGFRVRKRTCTNP 883
Query: 393 --RQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGN 450
R + + E+++ P G C W T W+ C
Sbjct: 884 EPRNGGLPCVGDAAEYQDCNPQACPVRGAWSC----W--TSWSPC--------------- 922
Query: 451 QTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP 510
+A CGGG R C A P + +C G CP
Sbjct: 923 -SASCGGGHYQRTRSC---------------TSPAPSPGE-DICLGLHTEEALCATQACP 965
Query: 511 TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGN------CPHLLE 564
SPWS W CT + G + R R G S GN CP+
Sbjct: 966 EGW--SPWSEWSKCTDD---------GAQSRSRHCEELLPGSSACAGNSSQSRPCPY--S 1012
Query: 565 AIPCEEPA 572
IP PA
Sbjct: 1013 EIPVILPA 1020
Score = 56.2 bits (134), Expect = 3e-07
Identities = 85/388 (21%), Positives = 127/388 (32%), Gaps = 85/388 (21%)
Query: 768 CKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAP 827
C ++ TP+S W C +SC G +R++S P +GGR C EE+ C
Sbjct: 661 CSRNGAWTPWSSWALCSTSCGIG-FQVRQRSCSN---PAPRHGGRICVGKSREERFCNEN 716
Query: 828 QACQ-SYRWKTH-KWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHEC 885
C W + W +C CG G Q+R C + G + +
Sbjct: 717 TPCPVPIFWASWGSWSKCS--------------SNCGGGMQSRRRAC---ENGNSCLGCG 759
Query: 886 LQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNS 945
+++ P C + + T W+ + N G R +R + C+
Sbjct: 760 VEFKTCNPE-------GCPEVRRNTPWTPWLPVNVTQGGARQEQRF-------RFTCRAP 805
Query: 946 HLYP--------LIETQYCPCDKYNAQPVGNWSDCILPEGKVE---VLLGMKVQGDIKEC 994
P ET+ CP D + + +L G V G G C
Sbjct: 806 LADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSC 865
Query: 995 GQ----GYRYQAMACYD---QNGRL------VETSRCNSHGYIEEACIIPCPSDCKLSEW 1041
+ G+R + C + +NG L E CN CP S W
Sbjct: 866 SRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQA---------CPVRGAWSCW 916
Query: 1042 SNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVT 1101
++WS CS SCG G + R + P P D E + C +
Sbjct: 917 TSWSPCSASCGGG-----HYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPW 971
Query: 1102 EPWSICKVTFVNMRENCGEGVQTRKVRC 1129
WS C +G Q+R C
Sbjct: 972 SEWSKC----------TDDGAQSRSRHC 989
Score = 53.5 bits (127), Expect = 2e-06
Identities = 98/409 (23%), Positives = 135/409 (33%), Gaps = 92/409 (22%)
Query: 1171 WGPWTQCVLPCNQSS----FRQRSADPIRQPADEGRSCPN-AVEKEPCNLNKNCYHYDYN 1225
W PW C +S R RS D R P G C A+ C+ N +
Sbjct: 615 WSPWQPCEHLDGDNSGSCLCRARSCDSPR-PRCGGLDCLGPAIHIANCSRNGAWTPW--- 670
Query: 1226 VTDWSTCQLSEKAVCGNGIKTRMLDCVRSD---------GKSVDLKYCEALGLEKNWQMN 1276
+ W+ C S CG G + R C GKS + ++C N
Sbjct: 671 -SSWALCSTS----CGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNE---------N 716
Query: 1277 TSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCP 1336
T C PV + W WS+CS CG G M RR + +G C + K C
Sbjct: 717 TPC----PVPIFWASWGSWSKCSSNCG--GGMQSRRRACE----NGNSCLGCGVEFKTCN 766
Query: 1337 VKPC----YRWQYGQWSPCQVQEAQCGEGTRTR-NISCVVSDGSADDFSK--------VV 1383
+ C + W P V + + R R ++D F +
Sbjct: 767 PEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPA 826
Query: 1384 DEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQV 1443
D D + +++ ++L + P W WS C C +LGF +V
Sbjct: 827 DGSGSCDTDALVE----VLLRSGSTSPHTVSGGWAAWGPWSSCSRDC----ELGF---RV 875
Query: 1444 RSRPVIIQELENQHL-CPEQMLETKSCYDGQCYEYKWMASAWKGSSRTVW--CQRSDGIN 1500
R R E N L C E + C C + AW S T W C S G
Sbjct: 876 RKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACP----VRGAW--SCWTSWSPCSASCG-- 927
Query: 1501 VTGGCLVMSQPDADRSCNPPCSQP--------HSYCSETKTCHCEEGYT 1541
GG RSC P P H+ + T C EG++
Sbjct: 928 --GG-----HYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWS 969
Score = 51.2 bits (121), Expect = 8e-06
Identities = 86/389 (22%), Positives = 132/389 (33%), Gaps = 114/389 (29%)
Query: 366 WSEWSPCSKTCHDMVSPAGTRVRTRTIR--------QFPIGSEKECPEFEEKEPCLSQGD 417
WS W+ CS +C G +VR R+ + +G +E E PC
Sbjct: 670 WSSWALCSTSCG-----IGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPC----- 719
Query: 418 GVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQL 477
VP W + W++C ++ CGGG+Q+R C N L
Sbjct: 720 -PVPIFWASWGS--WSKC----------------SSNCGGGMQSRRRACENGNSCL---- 756
Query: 478 STHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKG 537
++ K C CP +PW+ W P +Q ++
Sbjct: 757 --------GCGVEFKTCNPE----------GCPEVRRNTPWTPWLPVNVTQGGARQEQR- 797
Query: 538 FKLRKRRITNEPTG-----GSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDN---- 588
F+ R +P G T CP C+ A + +R G+ P
Sbjct: 798 FRFTCRAPLADPHGLQFGRRRTETRTCPADGSG-SCDTDALVE-VLLRSGSTSPHTVSGG 855
Query: 589 ----------GKECGPGTQVQEVVCINSD---------GEEVDRQLCRDAIFPIPVACDA 629
++C G +V++ C N + G+ + Q C P AC
Sbjct: 856 WAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCN------PQAC-- 907
Query: 630 PCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYA---GEEGGIRCPNSSALQEV 686
P S W++WS CS +C G G R RS + A GE+ + AL
Sbjct: 908 --PVRGAWSCWTSWSPCSASCGG----GHYQRTRSCTSPAPSPGEDICLGLHTEEALCAT 961
Query: 687 RSCNEHPCTVYHWQT-GPWGQCIEDTSVS 714
++C E W W +C +D + S
Sbjct: 962 QACPE------GWSPWSEWSKCTDDGAQS 984
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 84.0 bits (206), Expect = 1e-15
Identities = 91/366 (24%), Positives = 141/366 (38%), Gaps = 71/366 (19%)
Query: 204 SECSKTCGSGLQ-------HRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEELRYSLH 256
+ECS TCG G Q HR+ H AP + S E + C PC A
Sbjct: 627 TECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPA-----FWD 681
Query: 257 VGPWSTCS------MPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQN 310
+G WS CS M H + + + ++ + R + ++ PE + K Q
Sbjct: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQI 741
Query: 311 RQENKYWDIQ--IGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVI---TKECQVSE 365
R + + +G +TR+V C++ G D C + P ++C + K ++E
Sbjct: 742 RTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTE 801
Query: 366 WSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPI-GSEKECPEFEEKEPCLSQGDGVVPCA- 423
WSE CS C V T + P+ G P E PC + PC
Sbjct: 802 WSE--RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA--EATPCDNG-----PCTG 852
Query: 424 TYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNK 483
W W++C ++ CG G Q REV CV+ N + L +
Sbjct: 853 KVEWFAGSWSQCSIE----------------CGSGTQQREVICVRKNADTFEVLDPSECS 896
Query: 484 EASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRK 542
K P + Q CH+ PC + + WS C+ ++C QG GF++R+
Sbjct: 897 FLEK-----------PPSQQSCHLKPCGAKWFSTEWSM---CS-KSC---QG--GFRVRE 936
Query: 543 RRITNE 548
R ++
Sbjct: 937 VRCLSD 942
Score = 82.4 bits (202), Expect = 3e-15
Identities = 84/346 (24%), Positives = 128/346 (36%), Gaps = 56/346 (16%)
Query: 727 SCSVGMQTRKVICVRVNVGQVGPKK-CPESLRPETVR-PC-LLPCKKDCIVTPYSDWTSC 783
+C G Q CV + + P+ C S++P PC + PC + +W+ C
Sbjct: 632 TCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDI---GEWSEC 688
Query: 784 PSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRC 843
+C G +HR ++ R T Y + E P+ + + K C
Sbjct: 689 SKTCGLG-------MQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKI-----C 736
Query: 844 QLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQI-P 902
W ++ D CG G++ R + C G EC P + C + P
Sbjct: 737 S--EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDI--ENCDMGP 792
Query: 903 CQDDCQLTSWSKFSSCNGDCGA-VRTRKRTLVGK---SKKKEKCKNSHLYPLIETQYCPC 958
C LT WS+ C+ +CGA VRTR + S E C N+ PC
Sbjct: 793 CAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPC 850
Query: 959 DKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRC 1018
G+WS C + ECG G + + + C +N E
Sbjct: 851 TGKVEWFAGSWSQCSI------------------ECGSGTQQREVICVRKNADTFEVLDP 892
Query: 1019 NSHGYIEEACIIPCPSDCKL----SEW--SNWSRCSKSCGSGVKVR 1058
+ ++E+ P C L ++W + WS CSKSC G +VR
Sbjct: 893 SECSFLEKP---PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVR 935
Score = 81.6 bits (200), Expect = 6e-15
Identities = 93/359 (25%), Positives = 144/359 (40%), Gaps = 85/359 (23%)
Query: 1223 DYNVTDWSTCQLSEKAVCGNGIKTRMLDCV-RSDGKSVDLKYCEALGLEKNWQMNTSCMV 1281
D+N T + S CG G + + CV RS + YC++ ++ + +
Sbjct: 618 DHNWKQLGTTECS--TTCGKGSQYPIFRCVHRSTHEEAPESYCDS-SMKPTPEEEPCNIF 674
Query: 1282 ECPVNCQLSDWSPWSECSQTCG--------LTGKMIRRRTVT-QPFQGDGRPCPSLMDQS 1332
CP + +WS ECS+TCG L ++ R++T QP++ P + +
Sbjct: 675 PCPAFWDIGEWS---ECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKP---ETT 728
Query: 1333 KPCPVKPCYRWQY-GQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADI 1391
C +K C WQ W+ C V CG G RTR++ CV + G VVD+E C
Sbjct: 729 STCQLKICSEWQIRTDWTSCSV---PCGVGQRTRDVKCVSNIGD------VVDDEEC--- 776
Query: 1392 ELIIDGNKNMVLE----ESCSQ-PCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSR 1446
NM L E+C PC +L +WS C C G VR+R
Sbjct: 777 --------NMKLRPNDIENCDMGPCAKSWFLTEWS--ERCSAEC---------GAGVRTR 817
Query: 1447 PVI-----IQELENQHLCPEQMLETKSCYDGQCY-EYKWMASAWKGSS---------RTV 1491
V+ + L + + E C +G C + +W A +W S R V
Sbjct: 818 SVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREV 877
Query: 1492 WCQRSDG----INVTGGCLVMSQPDADRSCN-PPC-----SQPHSYCSETKTCHCEEGY 1540
C R + + C + +P + +SC+ PC S S CS++ C+ G+
Sbjct: 878 ICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKS----CQGGF 932
Score = 81.6 bits (200), Expect = 6e-15
Identities = 85/332 (25%), Positives = 132/332 (39%), Gaps = 59/332 (17%)
Query: 994 CGQGYRYQAMACYDQNGRL-VETSRCNSHGYI---EEAC-IIPCPSDCKLSEWSNWSRCS 1048
CG+G +Y C ++ S C+S EE C I PCP+ + EWS CS
Sbjct: 633 CGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSE---CS 689
Query: 1049 KSCGSGVKVRSKWLRE---------KPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLW 1099
K+CG G++ R R+ +PY C L+ ++ C W
Sbjct: 690 KTCGLGMQHRQVLCRQVYANRSLTVQPYR----CQHLEKPETTSTCQLKICSE------W 739
Query: 1100 -VTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVC 1158
+ W+ C V CG G +TR V+C+ N D V+D C+ + P C
Sbjct: 740 QIRTDWTSCSVP-------CGVGQRTRDVKCVSNIGD----VVDDEECNMKLRPNDIENC 788
Query: 1159 KL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRS----ADPIRQPADEGRSCPNAVEKEPC 1213
+ PC + ++EW +C C + R RS + + EG E PC
Sbjct: 789 DMGPCAKSWFLTEWS--ERCSAECG-AGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPC 845
Query: 1214 NLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD-LKYCEALGLEKN 1272
+ ++ WS C + CG+G + R + CVR + + + L E LEK
Sbjct: 846 DNGPCTGKVEWFAGSWSQCSIE----CGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
Query: 1273 WQMNTSCMVECPVNCQLSDW--SPWSECSQTC 1302
+ + C + W + WS CS++C
Sbjct: 902 PSQQSCHLKPCG-----AKWFSTEWSMCSKSC 928
Score = 77.8 bits (190), Expect = 8e-14
Identities = 100/430 (23%), Positives = 154/430 (35%), Gaps = 86/430 (20%)
Query: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCIN-SDGEEVDRQLCRDAIFPIPVA--CDA- 629
++WK + C CG G+Q C++ S EE C ++ P P C+
Sbjct: 619 HNWKQLGTTECSTT----CGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIF 674
Query: 630 PCPKDCVLSTWST--WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQ 684
PCP + W WS CS TC G + +Q+ R + YA + RC + +
Sbjct: 675 PCP-----AFWDIGEWSECSKTC-GLGMQHRQVLCRQV--YANRSLTVQPYRCQHLEKPE 726
Query: 685 EVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNV 744
+C C+ + +T W C C VG +TR V CV N+
Sbjct: 727 TTSTCQLKICSEWQIRTD-WTSC-----------------SVPCGVGQRTRDVKCVS-NI 767
Query: 745 GQ-VGPKKCPESLRPETVRPC-LLPCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRV 802
G V ++C LRP + C + PC K +T +S+ C + C G +
Sbjct: 768 GDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVRTRSVVCMTNH 825
Query: 803 IIQLPANGGRDC-TDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGC 861
+ LP G C + E C+ W W +C + C
Sbjct: 826 VSSLPLEG---CGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSI--------------EC 868
Query: 862 GPGRQARAITCRKQDGGQAGI---HECLQYAGPVPALTQACQI-PCQDDCQLTSWSKFSS 917
G G Q R + C +++ + EC P Q+C + PC T W S
Sbjct: 869 GSGTQQREVICVRKNADTFEVLDPSECSFL--EKPPSQQSCHLKPCGAKWFSTEW---SM 923
Query: 918 CNGDC-GAVRTRKRTLVG-------------KSKKKEKCKNSHLYPLIETQYCPCDKYNA 963
C+ C G R R+ + K +++E C P ++ + C YN
Sbjct: 924 CSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVD-ENCKDKYYNC 982
Query: 964 QPVGNWSDCI 973
V C+
Sbjct: 983 NVVVQARLCV 992
Score = 72.0 bits (175), Expect = 4e-12
Identities = 87/364 (23%), Positives = 130/364 (35%), Gaps = 56/364 (15%)
Query: 151 EGIQVREIACIQKDKDIPAEDIICEY-FEPKPLLEQACLIPCQQDCIVSEFSAWSECSKT 209
+G Q C+ + A + C+ +P P E + PC + E WSECSKT
Sbjct: 635 KGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGE---WSECSKT 691
Query: 210 CGSGLQHR---------TRHVVAPPQFGGSGCPNLTE---FQVCQSSPCEAEELRYSLHV 257
CG G+QHR R + P C +L + CQ C ++R
Sbjct: 692 CGLGMQHRQVLCRQVYANRSLTVQPY----RCQHLEKPETTSTCQLKICSEWQIRTD--- 744
Query: 258 GPWSTCSMP-----HSRQVRQARRRGKNKEREKDRSK-GVKDPEARELIKKKRNRNRQNR 311
W++CS+P +R V+ G + E+ K D E ++ ++
Sbjct: 745 --WTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEW 802
Query: 312 QENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEW--SEW 369
E + G +TR V+C+ + L C + P C EW W
Sbjct: 803 SERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNR-PAEATPCDNGPCTGKVEWFAGSW 861
Query: 370 SPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRT 429
S CS C + F + EC F EK P Q + PC W +
Sbjct: 862 SQCSIECGSGTQQREVICVRKNADTFEVLDPSEC-SFLEKPPS-QQSCHLKPCGA-KWFS 918
Query: 430 TEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQAN---ENLLSQLSTHKNKEAS 486
TEW+ C + C GG + REV C+ + NL + +E+
Sbjct: 919 TEWSMC----------------SKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
Query: 487 KPMD 490
P D
Sbjct: 963 NPQD 966
Score = 66.2 bits (160), Expect = 2e-10
Identities = 104/433 (24%), Positives = 165/433 (38%), Gaps = 85/433 (19%)
Query: 1120 EGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMP-----------LGSRVCKLPCPEDCVI 1168
E QT VR D S H D L P P LG+ C C +
Sbjct: 584 ESAQTFPVR----HPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKG--- 636
Query: 1169 SEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCYHYDYNVTD 1228
S++ P +CV + D +P E +EPCN+ +D + +
Sbjct: 637 SQY-PIFRCVHRSTHEEAPESYCDSSMKPTPE---------EEPCNIFPCPAFWD--IGE 684
Query: 1229 WSTCQLSEKAVCGNGIKTRMLDCVRS-DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNC 1287
WS C + CG G++ R + C + +S+ ++ LEK +T + C
Sbjct: 685 WSECSKT----CGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC---- 736
Query: 1288 QLSDW---SPWSECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPSLM--DQSKPCPVKPCY 1341
S+W + W+ CS CG+ + + V+ D C + + + C + PC
Sbjct: 737 --SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCA 794
Query: 1342 R-WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKN 1400
+ W +WS + A+CG G RTR++ C+ + S+ + E C GN
Sbjct: 795 KSWFLTEWS--ERCSAECGAGVRTRSVVCMTNHVSS------LPLEGC--------GNNR 838
Query: 1401 MVLEESCSQ-PCPGDCYLKDW--SSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQH 1457
C PC G +W SWS C + C +G I VR + L+
Sbjct: 839 PAEATPCDNGPCTGKV---EWFAGSWSQCSIECGSGTQQR-EVICVRKNADTFEVLDPSE 894
Query: 1458 LC-PEQMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQR----------SDGINVTGGCL 1506
E+ +SC+ C KW ++ W S++ CQ SD + ++ C
Sbjct: 895 CSFLEKPPSQQSCHLKPCGA-KWFSTEWSMCSKS--CQGGFRVREVRCLSDDMTLSNLCD 951
Query: 1507 VMSQPDADRSCNP 1519
+P+ SCNP
Sbjct: 952 PQLKPEERESCNP 964
Score = 41.6 bits (96), Expect = 0.006
Identities = 56/216 (25%), Positives = 72/216 (33%), Gaps = 52/216 (24%)
Query: 66 WGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWR 125
W C CG G +TR V C G C RPN+ +N CD W
Sbjct: 745 WTSC-SVPCGVGQ-RTRDVKCVSNIGDVVDDEECNMKLRPNDIEN----CDMGPCAKSWF 798
Query: 126 LGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKD-KDIPAEDIICEYFEPKPLLE 184
L W++ EC G++ R + C+ +P E C P
Sbjct: 799 LTEWSE---------RCSAEC---GAGVRTRSVVCMTNHVSSLPLEG--CGNNRP----- 839
Query: 185 QACLIPCQQDCIVSEF----SAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV 240
A PC + +WS+CS CGSG Q R V N F+V
Sbjct: 840 -AEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVR---------KNADTFEV 889
Query: 241 CQSSPC---EAEELRYSLHVGP---------WSTCS 264
S C E + S H+ P WS CS
Sbjct: 890 LDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCS 925
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 78.6 bits (192), Expect = 5e-14
Identities = 54/180 (30%), Positives = 77/180 (42%), Gaps = 24/180 (13%)
Query: 1227 TDWSTCQLSEKAVCGNGIKTRMLDCV----RSDGKSVDLKYCEALGLEKNWQMNTSCMVE 1282
++W++C S CGNGI+ R C R +G SV + C +K ++ +
Sbjct: 386 SEWTSCSTS----CGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGW--- 438
Query: 1283 CPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPF-QGDGRPCPSLMDQSKPCPVKPC- 1340
S WSPWS CS TCG G + R R P Q +G+PC ++K C C
Sbjct: 439 -------SHWSPWSSCSVTCG-DGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
Query: 1341 YRWQYGQWSPCQVQEAQCGEGTRTRNISC---VVSDGSADDFSKVVDEEFCADIELIIDG 1397
+G WSP + CG G + R+ C G D V + + C + IDG
Sbjct: 491 INGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDG 550
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/250 (26%), Positives = 94/250 (37%), Gaps = 51/250 (20%)
Query: 1026 EACIIPCPSDCK---LSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQA 1082
E C PSD S WS W+ CS SCG+G++ R GR C L++ +
Sbjct: 367 ECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQR-----------GRSCDSLNNRCEG 415
Query: 1083 QVYEVVPCH-SDCNQYL-----WV-TEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTAD 1135
+ CH +C++ W PWS C VT CG+GV TR C +
Sbjct: 416 SSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT-------CGDGVITRIRLC-----N 463
Query: 1136 GPSEHVEDYLCDPEEMPLGSRVCKL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPI 1194
PS + C+ E ++ CK CP + W PW C + C ++
Sbjct: 464 SPSPQMNGKPCEGEARE--TKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNN 521
Query: 1195 RQPADEGRSCPNAV-EKEPCN---------LNKNCYH----YDYNVTDWSTCQLSEKAVC 1240
P G+ C V E + CN L+ C+ Y W C
Sbjct: 522 PTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWK-CGACPPGYS 580
Query: 1241 GNGIKTRMLD 1250
GNGI+ +D
Sbjct: 581 GNGIQCTDVD 590
Score = 62.4 bits (150), Expect = 4e-09
Identities = 58/206 (28%), Positives = 84/206 (40%), Gaps = 28/206 (13%)
Query: 1146 CDPEEMPLGSRVCKLPCPEDCVISEWGPW---TQCVLPC-NQSSFRQRSADPIRQPADEG 1201
C +P G C P D W PW T C C N R RS D + EG
Sbjct: 358 CSNATVPDGE-CCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRC-EG 415
Query: 1202 RSCPNAVEKEPCNLNKNCYHYDYNV-----TDWSTCQLSEKAVCGNGIKTRMLDCVRSDG 1256
S V+ C++ + + + + WS+C ++ CG+G+ TR+ C S
Sbjct: 416 SS----VQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVT----CGDGVITRIRLC-NSPS 466
Query: 1257 KSVDLKYCEALGLEKNWQMNTSCMVE-CPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVT 1315
++ K CE E +C + CP+N WSPW CS TCG G R R
Sbjct: 467 PQMNGKPCEGEARETK-----ACKKDACPINGGWGPWSPWDICSVTCG-GGVQKRSRLCN 520
Query: 1316 QPF-QGDGRPCPSLMDQSKPCPVKPC 1340
P Q G+ C + +++ C + C
Sbjct: 521 NPTPQFGGKDCVGDVTENQICNKQDC 546
Score = 59.3 bits (142), Expect = 3e-08
Identities = 63/221 (28%), Positives = 85/221 (38%), Gaps = 49/221 (22%)
Query: 616 CRDAIFPIPVACDAPCPKDCV---LSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEE 672
C +A P C P D S WS W+SCS +C G Q R RS +
Sbjct: 358 CSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCG----NGIQQRGRSC-----DS 408
Query: 673 GGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSV-- 730
RC SS + R+C+ C Q G W W+ +SCSV
Sbjct: 409 LNNRCEGSSV--QTRTCHIQECDKRFKQDGGWSH---------------WSPWSSCSVTC 451
Query: 731 --GMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKD-CIVT----PYSDWTSC 783
G+ TR +C + Q+ K C R CKKD C + P+S W C
Sbjct: 452 GDGVITRIRLCNSPS-PQMNGKPCEGEARETKA------CKKDACPINGGWGPWSPWDIC 504
Query: 784 PSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC 824
+C G ++K+SR P GG+DC + E + C
Sbjct: 505 SVTCGGG---VQKRSR-LCNNPTPQFGGKDCVGDVTENQIC 541
Score = 47.0 bits (110), Expect = 2e-04
Identities = 64/273 (23%), Positives = 86/273 (31%), Gaps = 77/273 (28%)
Query: 364 SEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVVPCA 423
S WSEW+ CS +C + + G + R + +E + Q DG
Sbjct: 383 SPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQ-DG----- 436
Query: 424 TYGW-RTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKN 482
GW + W+ C V CG G+ TR C
Sbjct: 437 --GWSHWSPWSSCSV----------------TCGDGVITRIRLC---------------- 462
Query: 483 KEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRK 542
S M+ K C G T CP PWS W C+ C G ++
Sbjct: 463 NSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSV-TCG------GGVQKR 515
Query: 543 RRITNEPT---GGSGVTG-----------NCP-------HLLEAIPCEEPACYDWKAVRL 581
R+ N PT GG G +CP + C WK
Sbjct: 516 SRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKC--- 572
Query: 582 GNCEP---DNGKECGPGTQVQEV--VCINSDGE 609
G C P NG +C + +EV C N +GE
Sbjct: 573 GACPPGYSGNGIQCTDVDECKEVPDACFNHNGE 605
Score = 44.3 bits (103), Expect = 0.001
Identities = 80/356 (22%), Positives = 120/356 (33%), Gaps = 87/356 (24%)
Query: 592 CGPGTQVQEVVC--INS--DGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCS 647
CG G Q + C +N+ +G V + C CD +D S WS WSSCS
Sbjct: 395 CGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQ------ECDKRFKQDGGWSHWSPWSSCS 448
Query: 648 HTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQC 707
TC +G R R + + + G C + +E ++C + C + + GPW
Sbjct: 449 VTCG----DGVITRIRLCNSPSPQMNGKPCEGEA--RETKACKKDACPI-NGGWGPW--- 498
Query: 708 IEDTSVSSFNTTTTWN-GEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETV---RP 763
+ W+ +C G+Q R +C Q G K C + + +
Sbjct: 499 ------------SPWDICSVTCGGGVQKRSRLC-NNPTPQFGGKDCVGDVTENQICNKQD 545
Query: 764 CLL------PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDP 817
C + PC T Y D + +C G S G CTD
Sbjct: 546 CPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYS----------------GNGIQCTD- 588
Query: 818 LYEEKACEAPQACQSYRWKTHKWRRCQLV-PWSVQQDSPGAQEGCGPGRQ------ARAI 870
++ E P AC ++ + RC+ P P G P Q A
Sbjct: 589 --VDECKEVPDACFNHNGE----HRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQ 642
Query: 871 TCRKQDGGQAGIHEC-----LQYAGPVPALTQACQ---------IPCQDDCQLTSW 912
C+ ++ G H+C Y G C+ I C +D L W
Sbjct: 643 VCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGW 698
Score = 42.7 bits (99), Expect = 0.003
Identities = 35/123 (28%), Positives = 52/123 (42%), Gaps = 8/123 (6%)
Query: 185 QACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNLTEFQVCQS 243
Q C +QD S +S WS CS TCG G+ R R +P PQ G C E + ++
Sbjct: 426 QECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPC----EGEARET 481
Query: 244 SPCEAEELRYSLHVGPWS---TCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI 300
C+ + + GPWS CS+ V++ R N + V D ++
Sbjct: 482 KACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQIC 541
Query: 301 KKK 303
K+
Sbjct: 542 NKQ 544
Score = 38.5 bits (88), Expect = 0.055
Identities = 69/281 (24%), Positives = 97/281 (34%), Gaps = 64/281 (22%)
Query: 775 TPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYR 834
+P+S+WTSC +SC G Q R R L C + + C Q C
Sbjct: 383 SPWSEWTSCSTSCGNG-----IQQRGRSCDSL----NNRCEGSSVQTRTCHI-QECDKRF 432
Query: 835 WKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPA 894
+ W PWS CG G R C G C A
Sbjct: 433 KQDGGWSHWS--PWS------SCSVTCGDGVITRIRLCNSPSPQMNG-KPCEGEARE--- 480
Query: 895 LTQACQIPCQDDCQLTS----WSKFSSCNGDC-GAVRTRKRTLVGKSKK---KEKCKNSH 946
T+AC+ +D C + WS + C+ C G V+ R R + + K+ +
Sbjct: 481 -TKACK---KDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVT 536
Query: 947 LYPLIETQYCPCD-----------KYNAQPVGNWSDCILPEGKVEVLLGMKVQ-GDIKEC 994
+ Q CP D K + P G+W P G G +Q D+ EC
Sbjct: 537 ENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPG----YSGNGIQCTDVDEC 592
Query: 995 GQGYRYQAMACYDQNGRLVETSRCNS--HGYIEEACIIPCP 1033
+ AC++ NG RC + GY +PCP
Sbjct: 593 ----KEVPDACFNHNGE----HRCENTDPGY----NCLPCP 621
Score = 37.0 bits (84), Expect = 0.16
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 15/75 (20%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEEL--RYS- 254
S +S W+ CS +CG+G+Q R R N E Q+ C +E R+
Sbjct: 383 SPWSEWTSCSTSCGNGIQQRGRSC--------DSLNNRCEGSSVQTRTCHIQECDKRFKQ 434
Query: 255 ----LHVGPWSTCSM 265
H PWS+CS+
Sbjct: 435 DGGWSHWSPWSSCSV 449
Score = 33.9 bits (76), Expect = 1.3
Identities = 34/133 (25%), Positives = 48/133 (36%), Gaps = 18/133 (13%)
Query: 1405 ESCSQPCPGDCYLKDWSSWS---LCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPE 1461
E C + P D WS WS C +C N GIQ R R L N+ C
Sbjct: 367 ECCPRCWPSDSADDGWSPWSEWTSCSTSCGN-------GIQQRGRS--CDSLNNR--CEG 415
Query: 1462 QMLETKSCYDGQCYEYKWMASAWKGSSRTVWCQRSDGINVTGGCLVMSQPDADRSCNPPC 1521
++T++C+ +C + W S C + G V + + P + PC
Sbjct: 416 SSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMN-GKPC 474
Query: 1522 SQPHSYCSETKTC 1534
ETK C
Sbjct: 475 ---EGEARETKAC 484
Score = 31.6 bits (70), Expect = 6.7
Identities = 30/130 (23%), Positives = 45/130 (34%), Gaps = 25/130 (19%)
Query: 1345 YGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLE 1404
+ +W+ C CG G + R SC + + S V C
Sbjct: 385 WSEWTSCSTS---CGNGIQQRGRSCDSLNNRCEGSS--VQTRTCH--------------I 425
Query: 1405 ESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQML 1464
+ C + D WS WS C +TC +G I++ + P N C +
Sbjct: 426 QECDKRFKQDGGWSHWSPWSSCSVTCGDGV---ITRIRLCNSP---SPQMNGKPCEGEAR 479
Query: 1465 ETKSCYDGQC 1474
ETK+C C
Sbjct: 480 ETKACKKDAC 489
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 78.2 bits (191), Expect = 6e-14
Identities = 120/480 (25%), Positives = 172/480 (35%), Gaps = 106/480 (22%)
Query: 994 CGQGYRYQAMACYDQNGR-LVETSRCNSHGYIE---EACII-PCPSDCKLSEWSNWSRCS 1048
CG G R+ +C DQ + LVET +C EAC++ PCP + ++ CS
Sbjct: 668 CGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CS 724
Query: 1049 KSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV--PCHSDCNQYLW-VTEPWS 1105
SCG G++ R E + + P AQ V C+ W V+EP S
Sbjct: 725 ASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 784
Query: 1106 ICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPED 1165
G G+ C+ ADG V + +E KLP PE
Sbjct: 785 CTSAG--------GAGLALENETCVPG-ADGLEAPVTEGPGSVDE--------KLPAPEP 827
Query: 1166 CV--------------------ISEWGP----------WT----QCVLPCNQSSFRQRSA 1191
CV S WG WT C + C + R
Sbjct: 828 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 887
Query: 1192 ---DPIRQPADE---GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIK 1245
+R P E G + +E C + Y + + C +S CG G+
Sbjct: 888 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKL---AACSVS----CGRGVV 940
Query: 1246 TRMLDCVRS----DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQT 1301
R+L C R+ DG+ + L + GL + + CP ++ P CS +
Sbjct: 941 RRILYCARAHGEDDGEEI-LLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP---CSAS 996
Query: 1302 CGLTGKMIRRRTVTQPFQG-----DGRPCPSLM--DQSKPCPVKPC-YRWQYGQWSPCQV 1353
CGL G R Q QG D C +L+ + S PC + C YRW G W C V
Sbjct: 997 CGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSV 1055
Query: 1354 QEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPG 1413
CG+G + R +C+ A V +FC + K + + + PC G
Sbjct: 1056 ---SCGDGIQRRRDTCLGPQAQAP-----VPADFCQHLP------KPVTVRGCWAGPCVG 1101
Score = 67.0 bits (162), Expect = 1e-10
Identities = 96/382 (25%), Positives = 135/382 (35%), Gaps = 82/382 (21%)
Query: 449 GNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCH-I 507
G +A CGGG++ R V CV+A +LL L + + ++ + L + C+
Sbjct: 721 GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL---------ETCNPQ 771
Query: 508 PCPTECEVSPWSAWGPCT--------YENCNDQQGKKGFK---------LRKRRITNEPT 550
PCP EVS S+ CT EN G G + + ++ EP
Sbjct: 772 PCPARWEVSEPSS---CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC 828
Query: 551 GGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGN-----CEPDNGK---ECGPGTQVQEVV 602
G H L+A E A W ++R G P G CG G +
Sbjct: 829 VGMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 887
Query: 603 CINSD-GEEVDRQLCRDAIFP---IPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGK 658
C++S V +LC A P V PCP + W CS G
Sbjct: 888 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCP--------ARWQYKLAACSVSCGRGV 939
Query: 659 QIRARSILAYAGEEGG------IRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTS 712
R GE+ G +C + +C+ PC W+ G C
Sbjct: 940 VRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC----- 993
Query: 713 VSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQ---VGPKKCPESLRPETVRPCLLPCK 769
ASC +G R V CV+++ GQ V C +RPE PCL+
Sbjct: 994 ------------SASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLI--- 1038
Query: 770 KDCIVTPY-SDWTSCPSSCKEG 790
DC + W C SC +G
Sbjct: 1039 ADCTYRWHVGTWMECSVSCGDG 1060
Score = 48.5 bits (114), Expect = 5e-05
Identities = 60/242 (24%), Positives = 84/242 (34%), Gaps = 41/242 (16%)
Query: 38 LLLRPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTT--- 94
L +PG+ R Q P + +K CG G ++ R ++CA G
Sbjct: 904 LASKPGSRREVCQA-VPCPARWQYKLA----ACSVSCGRGVVR-RILYCARAHGEDDGEE 957
Query: 95 --LHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEG 152
L T C+ RP Q+ C L P C P P G G
Sbjct: 958 ILLDTQCQGLPRPEPQEAC-------------SLEP---CPPRWKVMSLGPCSASCGL-G 1000
Query: 153 IQVREIACIQKDK--DIPAEDIICEYFEPKPLLEQACLIPCQQDCIVS-EFSAWSECSKT 209
R +AC+Q D+ D+ ++ C +P CLI DC W ECS +
Sbjct: 1001 TARRSVACVQLDQGQDVEVDEAACAALV-RPEASVPCLIA---DCTYRWHVGTWMECSVS 1056
Query: 210 CGSGLQHRTRHVVAP------PQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTC 263
CG G+Q R + P P P + C + PC + H+ P T
Sbjct: 1057 CGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTI 1116
Query: 264 SM 265
M
Sbjct: 1117 DM 1118
Score = 42.4 bits (98), Expect = 0.004
Identities = 41/155 (26%), Positives = 60/155 (38%), Gaps = 30/155 (19%)
Query: 1298 CSQTCGLTGKMIR-------RRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYR-WQYGQWS 1349
CS +CG + + R+ + + Q G P ++ C ++PC W G +
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA--CVLEPCPPYWAVGDFG 721
Query: 1350 PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCS- 1408
PC A CG G R R + CV + GS K + C + V E+C+
Sbjct: 722 PCS---ASCGGGLRERPVRCVEAQGS---LLKTLPPARCR-----AGAQQPAVALETCNP 770
Query: 1409 QPC--------PGDCYLKDWSSWSLCQLTCVNGED 1435
QPC P C + +L TCV G D
Sbjct: 771 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGAD 805
Score = 38.1 bits (87), Expect = 0.071
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 200 FSAW---SECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNL-TEFQVCQSSPCEAEELRY 253
+S+W S CS++CG G+ R R P P FGG C + ++C + CE +L +
Sbjct: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEF 414
Score = 36.2 bits (82), Expect = 0.27
Identities = 35/134 (26%), Positives = 54/134 (40%), Gaps = 16/134 (11%)
Query: 152 GIQVREIACIQKDKDIPAEDII----CEYFEPKPLLEQAC-LIPCQQDCIVSEFSAWSEC 206
G+ R + C + + E+I+ C+ P+P ++AC L PC V C
Sbjct: 938 GVVRRILYCARAHGEDDGEEILLDTQCQGL-PRPEPQEACSLEPCPPRWKVMSLGP---C 993
Query: 207 SKTCGSGLQHRTRHVVAPPQ-----FGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWS 261
S +CG G R+ V Q + C L + S PC + Y HVG W
Sbjct: 994 SASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA--SVPCLIADCTYRWHVGTWM 1051
Query: 262 TCSMPHSRQVRQAR 275
CS+ +++ R
Sbjct: 1052 ECSVSCGDGIQRRR 1065
Score = 35.8 bits (81), Expect = 0.35
Identities = 83/408 (20%), Positives = 132/408 (32%), Gaps = 89/408 (21%)
Query: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDG---EEVDRQLCRDAIFPIPVA 626
EP W G C CG G + + V C+ + G + + CR VA
Sbjct: 709 EPCPPYWAVGDFGPCSAS----CGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVA 764
Query: 627 CDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEG------------- 673
+ P+ C + W S T +G G + + G +G
Sbjct: 765 LETCNPQPCP-ARWEVSEPSSCTSAG----GAGLALENETCVPGADGLEAPVTEGPGSVD 819
Query: 674 ----------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWN 723
G+ CP + S E PWG + T +
Sbjct: 820 EKLPAPEPCVGMSCPPGWGHLDATSAGEKA-------PSPWGSIRTGAQAAHVWTPAAGS 872
Query: 724 GEASCSVGMQTRKVICV----RVNVGQVGPKKCPESLRPETVRPCL--LPCKKDCIVTPY 777
SC G+ + +C+ RV V + + C + +P + R +PC
Sbjct: 873 CSVSCGRGLMELRFLCMDSALRVPVQE---ELCGLASKPGSRREVCQAVPCP-------- 921
Query: 778 SDW----TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSY 833
+ W +C SC G R++ A+G D + L + + P
Sbjct: 922 ARWQYKLAACSVSCGRGVV-------RRILYCARAHGEDDGEEILLDTQCQGLP------ 968
Query: 834 RWKTHKWRRCQLVP----WSVQQDSPGAQEGCGPGRQARAITCRKQDGGQ-AGIHECLQY 888
+ C L P W V P CG G R++ C + D GQ + E
Sbjct: 969 --RPEPQEACSLEPCPPRWKVMSLGP-CSASCGLGTARRSVACVQLDQGQDVEVDEAACA 1025
Query: 889 AGPVPALTQACQI-PCQDDCQLTSWSKFSSCNGDCG-AVRTRKRTLVG 934
A P + C I C + +W + C+ CG ++ R+ T +G
Sbjct: 1026 ALVRPEASVPCLIADCTYRWHVGTWME---CSVSCGDGIQRRRDTCLG 1070
Score = 35.4 bits (80), Expect = 0.46
Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 14/108 (12%)
Query: 152 GIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLI-PCQQDCIVSEFSAWSECSKTC 210
G++ +C+ + + E + C+ + P +AC++ PC V +F CS +C
Sbjct: 671 GLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CSASC 727
Query: 211 GSGLQHRTRHVV---------APPQFGGSGCPN-LTEFQVCQSSPCEA 248
G GL+ R V PP +G + C PC A
Sbjct: 728 GGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA 775
Score = 35.0 bits (79), Expect = 0.60
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Query: 1285 VNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPCYRW 1343
V+ + S W P S CS++CG G + RRR P GR C Q++ C + C +
Sbjct: 352 VHGRWSSWGPRSPCSRSCG-GGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKT 410
Query: 1344 Q 1344
Q
Sbjct: 411 Q 411
Score = 34.7 bits (78), Expect = 0.79
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 4/41 (9%)
Query: 1041 WSNW---SRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPKLD 1077
WS+W S CS+SCG GV R + +P GGR C D
Sbjct: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
Score = 33.9 bits (76), Expect = 1.3
Identities = 44/164 (26%), Positives = 58/164 (35%), Gaps = 38/164 (23%)
Query: 343 CQQEKLPMTFQSCVITKECQVSEWSEWS--PCSKTCHDMVSPAGTRVRTRTIRQFPIGSE 400
CQ P ++C + E W S PCS +C GT R+ Q G +
Sbjct: 964 CQGLPRPEPQEACSL--EPCPPRWKVMSLGPCSASCG-----LGTARRSVACVQLDQGQD 1016
Query: 401 KECPEFEEKEPCLSQGDGVVPC----ATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCG 456
E E L + + VPC TY W W EC V CG
Sbjct: 1017 VEVDE--AACAALVRPEASVPCLIADCTYRWHVGTWMECSVS----------------CG 1058
Query: 457 GGIQTREVYCV--QANENLLSQLSTHKNKEASKPMDLKLC-TGP 497
GIQ R C+ QA + + H KP+ ++ C GP
Sbjct: 1059 DGIQRRRDTCLGPQAQAPVPADFCQH----LPKPVTVRGCWAGP 1098
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 78.2 bits (191), Expect = 6e-14
Identities = 120/480 (25%), Positives = 172/480 (35%), Gaps = 106/480 (22%)
Query: 994 CGQGYRYQAMACYDQNGR-LVETSRCNSHGYIE---EACII-PCPSDCKLSEWSNWSRCS 1048
CG G R+ +C DQ + LVET +C EAC++ PCP + ++ CS
Sbjct: 699 CGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CS 755
Query: 1049 KSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV--PCHSDCNQYLW-VTEPWS 1105
SCG G++ R E + + P AQ V C+ W V+EP S
Sbjct: 756 ASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 1106 ICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPED 1165
G G+ C+ ADG V + +E KLP PE
Sbjct: 816 CTSAG--------GAGLALENETCVPG-ADGLEAPVTEGPGSVDE--------KLPAPEP 858
Query: 1166 CV--------------------ISEWGP----------WT----QCVLPCNQSSFRQRSA 1191
CV S WG WT C + C + R
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 918
Query: 1192 ---DPIRQPADE---GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIK 1245
+R P E G + +E C + Y + + C +S CG G+
Sbjct: 919 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKL---AACSVS----CGRGVV 971
Query: 1246 TRMLDCVRS----DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQT 1301
R+L C R+ DG+ + L + GL + + CP ++ P CS +
Sbjct: 972 RRILYCARAHGEDDGEEI-LLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP---CSAS 1027
Query: 1302 CGLTGKMIRRRTVTQPFQG-----DGRPCPSLM--DQSKPCPVKPC-YRWQYGQWSPCQV 1353
CGL G R Q QG D C +L+ + S PC + C YRW G W C V
Sbjct: 1028 CGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSV 1086
Query: 1354 QEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPG 1413
CG+G + R +C+ A V +FC + K + + + PC G
Sbjct: 1087 ---SCGDGIQRRRDTCLGPQAQAP-----VPADFCQHLP------KPVTVRGCWAGPCVG 1132
Score = 67.0 bits (162), Expect = 1e-10
Identities = 96/382 (25%), Positives = 135/382 (35%), Gaps = 82/382 (21%)
Query: 449 GNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCH-I 507
G +A CGGG++ R V CV+A +LL L + + ++ + L + C+
Sbjct: 752 GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL---------ETCNPQ 802
Query: 508 PCPTECEVSPWSAWGPCT--------YENCNDQQGKKGFK---------LRKRRITNEPT 550
PCP EVS S+ CT EN G G + + ++ EP
Sbjct: 803 PCPARWEVSEPSS---CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC 859
Query: 551 GGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGN-----CEPDNGK---ECGPGTQVQEVV 602
G H L+A E A W ++R G P G CG G +
Sbjct: 860 VGMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 918
Query: 603 CINSD-GEEVDRQLCRDAIFP---IPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGK 658
C++S V +LC A P V PCP + W CS G
Sbjct: 919 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCP--------ARWQYKLAACSVSCGRGV 970
Query: 659 QIRARSILAYAGEEGG------IRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTS 712
R GE+ G +C + +C+ PC W+ G C
Sbjct: 971 VRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC----- 1024
Query: 713 VSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQ---VGPKKCPESLRPETVRPCLLPCK 769
ASC +G R V CV+++ GQ V C +RPE PCL+
Sbjct: 1025 ------------SASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLI--- 1069
Query: 770 KDCIVTPY-SDWTSCPSSCKEG 790
DC + W C SC +G
Sbjct: 1070 ADCTYRWHVGTWMECSVSCGDG 1091
Score = 48.5 bits (114), Expect = 5e-05
Identities = 60/242 (24%), Positives = 84/242 (34%), Gaps = 41/242 (16%)
Query: 38 LLLRPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTT--- 94
L +PG+ R Q P + +K CG G ++ R ++CA G
Sbjct: 935 LASKPGSRREVCQA-VPCPARWQYKLA----ACSVSCGRGVVR-RILYCARAHGEDDGEE 988
Query: 95 --LHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEG 152
L T C+ RP Q+ C L P C P P G G
Sbjct: 989 ILLDTQCQGLPRPEPQEAC-------------SLEP---CPPRWKVMSLGPCSASCGL-G 1031
Query: 153 IQVREIACIQKDK--DIPAEDIICEYFEPKPLLEQACLIPCQQDCIVS-EFSAWSECSKT 209
R +AC+Q D+ D+ ++ C +P CLI DC W ECS +
Sbjct: 1032 TARRSVACVQLDQGQDVEVDEAACAALV-RPEASVPCLIA---DCTYRWHVGTWMECSVS 1087
Query: 210 CGSGLQHRTRHVVAP------PQFGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWSTC 263
CG G+Q R + P P P + C + PC + H+ P T
Sbjct: 1088 CGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTI 1147
Query: 264 SM 265
M
Sbjct: 1148 DM 1149
Score = 42.4 bits (98), Expect = 0.004
Identities = 41/155 (26%), Positives = 60/155 (38%), Gaps = 30/155 (19%)
Query: 1298 CSQTCGLTGKMIR-------RRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYR-WQYGQWS 1349
CS +CG + + R+ + + Q G P ++ C ++PC W G +
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA--CVLEPCPPYWAVGDFG 752
Query: 1350 PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCS- 1408
PC A CG G R R + CV + GS K + C + V E+C+
Sbjct: 753 PCS---ASCGGGLRERPVRCVEAQGS---LLKTLPPARCR-----AGAQQPAVALETCNP 801
Query: 1409 QPC--------PGDCYLKDWSSWSLCQLTCVNGED 1435
QPC P C + +L TCV G D
Sbjct: 802 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGAD 836
Score = 38.1 bits (87), Expect = 0.071
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 200 FSAW---SECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNL-TEFQVCQSSPCEAEELRY 253
+S+W S CS++CG G+ R R P P FGG C + ++C + CE +L +
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEF 445
Score = 36.2 bits (82), Expect = 0.27
Identities = 35/134 (26%), Positives = 54/134 (40%), Gaps = 16/134 (11%)
Query: 152 GIQVREIACIQKDKDIPAEDII----CEYFEPKPLLEQAC-LIPCQQDCIVSEFSAWSEC 206
G+ R + C + + E+I+ C+ P+P ++AC L PC V C
Sbjct: 969 GVVRRILYCARAHGEDDGEEILLDTQCQGL-PRPEPQEACSLEPCPPRWKVMSLGP---C 1024
Query: 207 SKTCGSGLQHRTRHVVAPPQ-----FGGSGCPNLTEFQVCQSSPCEAEELRYSLHVGPWS 261
S +CG G R+ V Q + C L + S PC + Y HVG W
Sbjct: 1025 SASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA--SVPCLIADCTYRWHVGTWM 1082
Query: 262 TCSMPHSRQVRQAR 275
CS+ +++ R
Sbjct: 1083 ECSVSCGDGIQRRR 1096
Score = 35.8 bits (81), Expect = 0.35
Identities = 83/408 (20%), Positives = 132/408 (32%), Gaps = 89/408 (21%)
Query: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDG---EEVDRQLCRDAIFPIPVA 626
EP W G C CG G + + V C+ + G + + CR VA
Sbjct: 740 EPCPPYWAVGDFGPCSAS----CGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVA 795
Query: 627 CDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEG------------- 673
+ P+ C + W S T +G G + + G +G
Sbjct: 796 LETCNPQPCP-ARWEVSEPSSCTSAG----GAGLALENETCVPGADGLEAPVTEGPGSVD 850
Query: 674 ----------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWN 723
G+ CP + S E PWG + T +
Sbjct: 851 EKLPAPEPCVGMSCPPGWGHLDATSAGEKA-------PSPWGSIRTGAQAAHVWTPAAGS 903
Query: 724 GEASCSVGMQTRKVICV----RVNVGQVGPKKCPESLRPETVRPCL--LPCKKDCIVTPY 777
SC G+ + +C+ RV V + + C + +P + R +PC
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQE---ELCGLASKPGSRREVCQAVPCP-------- 952
Query: 778 SDW----TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSY 833
+ W +C SC G R++ A+G D + L + + P
Sbjct: 953 ARWQYKLAACSVSCGRGVV-------RRILYCARAHGEDDGEEILLDTQCQGLP------ 999
Query: 834 RWKTHKWRRCQLVP----WSVQQDSPGAQEGCGPGRQARAITCRKQDGGQ-AGIHECLQY 888
+ C L P W V P CG G R++ C + D GQ + E
Sbjct: 1000 --RPEPQEACSLEPCPPRWKVMSLGP-CSASCGLGTARRSVACVQLDQGQDVEVDEAACA 1056
Query: 889 AGPVPALTQACQI-PCQDDCQLTSWSKFSSCNGDCG-AVRTRKRTLVG 934
A P + C I C + +W + C+ CG ++ R+ T +G
Sbjct: 1057 ALVRPEASVPCLIADCTYRWHVGTWME---CSVSCGDGIQRRRDTCLG 1101
Score = 35.4 bits (80), Expect = 0.46
Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 14/108 (12%)
Query: 152 GIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLI-PCQQDCIVSEFSAWSECSKTC 210
G++ +C+ + + E + C+ + P +AC++ PC V +F CS +C
Sbjct: 702 GLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CSASC 758
Query: 211 GSGLQHRTRHVV---------APPQFGGSGCPN-LTEFQVCQSSPCEA 248
G GL+ R V PP +G + C PC A
Sbjct: 759 GGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA 806
Score = 35.0 bits (79), Expect = 0.60
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Query: 1285 VNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPCYRW 1343
V+ + S W P S CS++CG G + RRR P GR C Q++ C + C +
Sbjct: 383 VHGRWSSWGPRSPCSRSCG-GGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKT 441
Query: 1344 Q 1344
Q
Sbjct: 442 Q 442
Score = 34.7 bits (78), Expect = 0.79
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 4/41 (9%)
Query: 1041 WSNW---SRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPKLD 1077
WS+W S CS+SCG GV R + +P GGR C D
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 427
Score = 33.9 bits (76), Expect = 1.3
Identities = 44/164 (26%), Positives = 58/164 (35%), Gaps = 38/164 (23%)
Query: 343 CQQEKLPMTFQSCVITKECQVSEWSEWS--PCSKTCHDMVSPAGTRVRTRTIRQFPIGSE 400
CQ P ++C + E W S PCS +C GT R+ Q G +
Sbjct: 995 CQGLPRPEPQEACSL--EPCPPRWKVMSLGPCSASCG-----LGTARRSVACVQLDQGQD 1047
Query: 401 KECPEFEEKEPCLSQGDGVVPC----ATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCG 456
E E L + + VPC TY W W EC V CG
Sbjct: 1048 VEVDE--AACAALVRPEASVPCLIADCTYRWHVGTWMECSVS----------------CG 1089
Query: 457 GGIQTREVYCV--QANENLLSQLSTHKNKEASKPMDLKLC-TGP 497
GIQ R C+ QA + + H KP+ ++ C GP
Sbjct: 1090 DGIQRRRDTCLGPQAQAPVPADFCQH----LPKPVTVRGCWAGP 1129
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 78.2 bits (191), Expect = 6e-14
Identities = 120/480 (25%), Positives = 172/480 (35%), Gaps = 106/480 (22%)
Query: 994 CGQGYRYQAMACYDQNGR-LVETSRCNSHGYIE---EACII-PCPSDCKLSEWSNWSRCS 1048
CG G R+ +C DQ + LVET +C EAC++ PCP + ++ CS
Sbjct: 699 CGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CS 755
Query: 1049 KSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV--PCHSDCNQYLW-VTEPWS 1105
SCG G++ R E + + P AQ V C+ W V+EP S
Sbjct: 756 ASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 1106 ICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPED 1165
G G+ C+ ADG V + +E KLP PE
Sbjct: 816 CTSAG--------GAGLALENETCVPG-ADGLEAPVTEGPGSVDE--------KLPAPEP 858
Query: 1166 CV--------------------ISEWGP----------WT----QCVLPCNQSSFRQRSA 1191
CV S WG WT C + C + R
Sbjct: 859 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 918
Query: 1192 ---DPIRQPADE---GRSCPNAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIK 1245
+R P E G + +E C + Y + + C +S CG G+
Sbjct: 919 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKL---AACSVS----CGRGVV 971
Query: 1246 TRMLDCVRS----DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQT 1301
R+L C R+ DG+ + L + GL + + CP ++ P CS +
Sbjct: 972 RRILYCARAHGEDDGEEI-LLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP---CSAS 1027
Query: 1302 CGLTGKMIRRRTVTQPFQG-----DGRPCPSLM--DQSKPCPVKPC-YRWQYGQWSPCQV 1353
CGL G R Q QG D C +L+ + S PC + C YRW G W C V
Sbjct: 1028 CGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSV 1086
Query: 1354 QEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPG 1413
CG+G + R +C+ A V +FC + K + + + PC G
Sbjct: 1087 ---SCGDGIQRRRDTCLGPQAQAP-----VPADFCQHLP------KPVTVRGCWAGPCVG 1132
Score = 67.0 bits (162), Expect = 1e-10
Identities = 96/382 (25%), Positives = 135/382 (35%), Gaps = 82/382 (21%)
Query: 449 GNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCH-I 507
G +A CGGG++ R V CV+A +LL L + + ++ + L + C+
Sbjct: 752 GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL---------ETCNPQ 802
Query: 508 PCPTECEVSPWSAWGPCT--------YENCNDQQGKKGFK---------LRKRRITNEPT 550
PCP EVS S+ CT EN G G + + ++ EP
Sbjct: 803 PCPARWEVSEPSS---CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC 859
Query: 551 GGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGN-----CEPDNGK---ECGPGTQVQEVV 602
G H L+A E A W ++R G P G CG G +
Sbjct: 860 VGMSCPPGWGH-LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFL 918
Query: 603 CINSD-GEEVDRQLCRDAIFP---IPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGK 658
C++S V +LC A P V PCP + W CS G
Sbjct: 919 CMDSALRVPVQEELCGLASKPGSRREVCQAVPCP--------ARWQYKLAACSVSCGRGV 970
Query: 659 QIRARSILAYAGEEGG------IRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTS 712
R GE+ G +C + +C+ PC W+ G C
Sbjct: 971 VRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP-RWKVMSLGPC----- 1024
Query: 713 VSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQ---VGPKKCPESLRPETVRPCLLPCK 769
ASC +G R V CV+++ GQ V C +RPE PCL+
Sbjct: 1025 ------------SASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLI--- 1069
Query: 770 KDCIVTPY-SDWTSCPSSCKEG 790
DC + W C SC +G
Sbjct: 1070 ADCTYRWHVGTWMECSVSCGDG 1091
Score = 45.8 bits (107), Expect = 3e-04
Identities = 61/259 (23%), Positives = 90/259 (34%), Gaps = 45/259 (17%)
Query: 38 LLLRPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTT--- 94
L +PG+ R Q P + +K CG G ++ R ++CA G
Sbjct: 935 LASKPGSRREVCQA-VPCPARWQYKLA----ACSVSCGRGVVR-RILYCARAHGEDDGEE 988
Query: 95 --LHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEG 152
L T C+ RP Q+ C L P C P P G G
Sbjct: 989 ILLDTQCQGLPRPEPQEAC-------------SLEP---CPPRWKVMSLGPCSASCGL-G 1031
Query: 153 IQVREIACIQKDK--DIPAEDIICEYFEPKPLLEQACLIPCQQDCIVS-EFSAWSECSKT 209
R +AC+Q D+ D+ ++ C +P CLI DC W ECS +
Sbjct: 1032 TARRSVACVQLDQGQDVEVDEAACAALV-RPEASVPCLIA---DCTYRWHVGTWMECSVS 1087
Query: 210 CGSGLQHRTRHVVAP------PQFGGSGCPNLTEFQVCQSSPCEAEE----LRYSLHVGP 259
CG G+Q R + P P P + C + PC + + + P
Sbjct: 1088 CGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVPHEEAAAP 1147
Query: 260 WSTCSMPHSRQVRQARRRG 278
T + P + ++ RG
Sbjct: 1148 GRTTATPAGASLEWSQARG 1166
Score = 42.4 bits (98), Expect = 0.004
Identities = 41/155 (26%), Positives = 60/155 (38%), Gaps = 30/155 (19%)
Query: 1298 CSQTCGLTGKMIR-------RRTVTQPFQGDGRPCPSLMDQSKPCPVKPCYR-WQYGQWS 1349
CS +CG + + R+ + + Q G P ++ C ++PC W G +
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA--CVLEPCPPYWAVGDFG 752
Query: 1350 PCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEESCS- 1408
PC A CG G R R + CV + GS K + C + V E+C+
Sbjct: 753 PCS---ASCGGGLRERPVRCVEAQGS---LLKTLPPARCR-----AGAQQPAVALETCNP 801
Query: 1409 QPC--------PGDCYLKDWSSWSLCQLTCVNGED 1435
QPC P C + +L TCV G D
Sbjct: 802 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGAD 836
Score = 38.1 bits (87), Expect = 0.071
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 200 FSAW---SECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNL-TEFQVCQSSPCEAEELRY 253
+S+W S CS++CG G+ R R P P FGG C + ++C + CE +L +
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEF 445
Score = 35.8 bits (81), Expect = 0.35
Identities = 83/408 (20%), Positives = 132/408 (32%), Gaps = 89/408 (21%)
Query: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDG---EEVDRQLCRDAIFPIPVA 626
EP W G C CG G + + V C+ + G + + CR VA
Sbjct: 740 EPCPPYWAVGDFGPCSAS----CGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVA 795
Query: 627 CDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEG------------- 673
+ P+ C + W S T +G G + + G +G
Sbjct: 796 LETCNPQPCP-ARWEVSEPSSCTSAG----GAGLALENETCVPGADGLEAPVTEGPGSVD 850
Query: 674 ----------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWN 723
G+ CP + S E PWG + T +
Sbjct: 851 EKLPAPEPCVGMSCPPGWGHLDATSAGEKA-------PSPWGSIRTGAQAAHVWTPAAGS 903
Query: 724 GEASCSVGMQTRKVICV----RVNVGQVGPKKCPESLRPETVRPCL--LPCKKDCIVTPY 777
SC G+ + +C+ RV V + + C + +P + R +PC
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQE---ELCGLASKPGSRREVCQAVPCP-------- 952
Query: 778 SDW----TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSY 833
+ W +C SC G R++ A+G D + L + + P
Sbjct: 953 ARWQYKLAACSVSCGRGVV-------RRILYCARAHGEDDGEEILLDTQCQGLP------ 999
Query: 834 RWKTHKWRRCQLVP----WSVQQDSPGAQEGCGPGRQARAITCRKQDGGQ-AGIHECLQY 888
+ C L P W V P CG G R++ C + D GQ + E
Sbjct: 1000 --RPEPQEACSLEPCPPRWKVMSLGP-CSASCGLGTARRSVACVQLDQGQDVEVDEAACA 1056
Query: 889 AGPVPALTQACQI-PCQDDCQLTSWSKFSSCNGDCG-AVRTRKRTLVG 934
A P + C I C + +W + C+ CG ++ R+ T +G
Sbjct: 1057 ALVRPEASVPCLIADCTYRWHVGTWME---CSVSCGDGIQRRRDTCLG 1101
Score = 35.4 bits (80), Expect = 0.46
Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 14/108 (12%)
Query: 152 GIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLI-PCQQDCIVSEFSAWSECSKTC 210
G++ +C+ + + E + C+ + P +AC++ PC V +F CS +C
Sbjct: 702 GLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP---CSASC 758
Query: 211 GSGLQHRTRHVV---------APPQFGGSGCPN-LTEFQVCQSSPCEA 248
G GL+ R V PP +G + C PC A
Sbjct: 759 GGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA 806
Score = 35.0 bits (79), Expect = 0.60
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 2/61 (3%)
Query: 1285 VNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPCYRW 1343
V+ + S W P S CS++CG G + RRR P GR C Q++ C + C +
Sbjct: 383 VHGRWSSWGPRSPCSRSCG-GGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKT 441
Query: 1344 Q 1344
Q
Sbjct: 442 Q 442
Score = 34.7 bits (78), Expect = 0.79
Identities = 18/41 (43%), Positives = 22/41 (53%), Gaps = 4/41 (9%)
Query: 1041 WSNW---SRCSKSCGSGVKVRSKWLRE-KPYNGGRPCPKLD 1077
WS+W S CS+SCG GV R + +P GGR C D
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 427
Score = 33.9 bits (76), Expect = 1.3
Identities = 44/164 (26%), Positives = 58/164 (35%), Gaps = 38/164 (23%)
Query: 343 CQQEKLPMTFQSCVITKECQVSEWSEWS--PCSKTCHDMVSPAGTRVRTRTIRQFPIGSE 400
CQ P ++C + E W S PCS +C GT R+ Q G +
Sbjct: 995 CQGLPRPEPQEACSL--EPCPPRWKVMSLGPCSASCG-----LGTARRSVACVQLDQGQD 1047
Query: 401 KECPEFEEKEPCLSQGDGVVPC----ATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCG 456
E E L + + VPC TY W W EC V CG
Sbjct: 1048 VEVDE--AACAALVRPEASVPCLIADCTYRWHVGTWMECSVS----------------CG 1089
Query: 457 GGIQTREVYCV--QANENLLSQLSTHKNKEASKPMDLKLC-TGP 497
GIQ R C+ QA + + H KP+ ++ C GP
Sbjct: 1090 DGIQRRRDTCLGPQAQAPVPADFCQH----LPKPVTVRGCWAGP 1129
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 75.5 bits (184), Expect = 4e-13
Identities = 77/313 (24%), Positives = 111/313 (35%), Gaps = 101/313 (32%)
Query: 1035 DCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDC 1094
D EWS WS CS +CG G++VR++ PY G C + E PC++
Sbjct: 309 DPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPY--GTLC-------SGPLRETRPCNNSA 359
Query: 1095 N---QYLWVT-EPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEE 1150
+W WS+C +CG G ++R C+ P +H PE
Sbjct: 360 TCPVHGVWEEWGSWSLCS-------RSCGRGSRSRMRTCV------PPQHGGKACEGPE- 405
Query: 1151 MPLGSRVCKL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVE 1209
L +++C + CP + EWGPW C C + ++ + PA
Sbjct: 406 --LQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPA----------- 452
Query: 1210 KEPCNLNKNCYHYDYNVTDWSTC--QLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEAL 1267
W+TC L++ C N L+C +D K
Sbjct: 453 -------------------WATCTGALTDTRECSN------LECPATDSK---------- 477
Query: 1268 GLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPS 1327
W W+ WS CS+TC TG RR + Q G PC
Sbjct: 478 -----W----------------GPWNAWSLCSKTCD-TGWQ-RRFRMCQATGTQGYPCEG 514
Query: 1328 LMDQSKPCPVKPC 1340
++ KPC K C
Sbjct: 515 TGEEVKPCSEKRC 527
Score = 70.1 bits (170), Expect = 2e-11
Identities = 58/211 (27%), Positives = 80/211 (37%), Gaps = 23/211 (10%)
Query: 1165 DCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAV-EKEPCNLNKNCYHYD 1223
D EW PW+ C L C Q + R+ + P G C + E PCN + C +
Sbjct: 309 DPAAEEWSPWSVCSLTCGQG-LQVRTRSCVSSPY--GTLCSGPLRETRPCNNSATCPVHG 365
Query: 1224 Y--NVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMV 1281
WS C S CG G ++RM CV K CE L Q M
Sbjct: 366 VWEEWGSWSLCSRS----CGRGSRSRMRTCVPPQHGG---KACEGPEL----QTKLCSMA 414
Query: 1282 ECPVNCQLSDWSPWSECSQTCGL-TGKMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
CPV Q +W PW CS +C T + R+ +V P C + ++ C C
Sbjct: 415 ACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWA---TCTGALTDTRECSNLEC 471
Query: 1341 YRW--QYGQWSPCQVQEAQCGEGTRTRNISC 1369
++G W+ + C G + R C
Sbjct: 472 PATDSKWGPWNAWSLCSKTCDTGWQRRFRMC 502
Score = 66.6 bits (161), Expect = 2e-10
Identities = 61/226 (26%), Positives = 91/226 (40%), Gaps = 46/226 (20%)
Query: 1291 DWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKP------CPVKPCYRWQ 1344
+WSPWS CS TCG ++ R V+ P+ G C + +++P CPV + +
Sbjct: 314 EWSPWSVCSLTCGQGLQVRTRSCVSSPY---GTLCSGPLRETRPCNNSATCPVHGVWE-E 369
Query: 1345 YGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLE 1404
+G WS C CG G+R+R +CV + C EL
Sbjct: 370 WGSWSLC---SRSCGRGSRSRMRTCVPPQHGG---------KACEGPEL---------QT 408
Query: 1405 ESCSQ-PCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQM 1463
+ CS CP + +W W C +C N G Q RSR + C +
Sbjct: 409 KLCSMAACPVEGQWLEWGPWGPCSTSCAN-------GTQQRSRKCSVAG-PAWATCTGAL 460
Query: 1464 LETKSCYDGQC--YEYKWMA-SAWKGSSRTV---WCQRSDGINVTG 1503
+T+ C + +C + KW +AW S+T W +R TG
Sbjct: 461 TDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATG 506
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/239 (27%), Positives = 93/239 (38%), Gaps = 49/239 (20%)
Query: 994 CGQGYRYQAMACYDQ------NGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRC 1047
CGQG + + +C +G L ET CN+ CP EW +WS C
Sbjct: 325 CGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSA--------TCPVHGVWEEWGSWSLC 376
Query: 1048 SKSCGSGVKVRSKWLREKPYNGGRPC--PKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWS 1105
S+SCG G + R + P +GG+ C P+L Q ++ + C + W PW
Sbjct: 377 SRSCGRGSRSRMRTC-VPPQHGGKACEGPEL----QTKLCSMAACPVEGQWLEW--GPWG 429
Query: 1106 ICKVTFVNMRENCGEGVQTRKVRCMQNTADGPS-EHVEDYLCDPEEMPLGSRVCKLPCPE 1164
C +C G Q R +C + GP+ L D E L CP
Sbjct: 430 PCST-------SCANGTQQRSRKC---SVAGPAWATCTGALTDTRE------CSNLECP- 472
Query: 1165 DCVISEWGP---WTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEK-EPCNLNKNC 1219
S+WGP W+ C C+ QR + +G C E+ +PC+ K C
Sbjct: 473 -ATDSKWGPWNAWSLCSKTCDTG--WQRRFRMCQATGTQGYPCEGTGEEVKPCS-EKRC 527
Score = 57.8 bits (138), Expect = 9e-08
Identities = 73/292 (25%), Positives = 100/292 (34%), Gaps = 87/292 (29%)
Query: 128 PWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQAC 187
PW+ C L C +G+QVR +C+ + E +P A
Sbjct: 317 PWSVCS----------LTC---GQGLQVRTRSCVSSPYGTLCSGPLRE---TRPCNNSAT 360
Query: 188 LIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGC--PNLTEFQVCQSSP 245
C + E+ +WS CS++CG G + R R V PPQ GG C P L + ++C +
Sbjct: 361 ---CPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCV-PPQHGGKACEGPEL-QTKLCSMAA 415
Query: 246 CEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRN 305
C E L GPW CS + N +++ R V P
Sbjct: 416 CPVE--GQWLEWGPWGPCSTSCA-----------NGTQQRSRKCSVAGPA---------- 452
Query: 306 RNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSE 365
W C TG D C + P T + +
Sbjct: 453 -----------W----------ATC---TGALTDTRECSNLECPAT--------DSKWGP 480
Query: 366 WSEWSPCSKTCHD-------MVSPAGTR--VRTRTIRQFPIGSEKECPEFEE 408
W+ WS CSKTC M GT+ T + SEK CP F E
Sbjct: 481 WNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHE 532
Score = 55.8 bits (133), Expect = 3e-07
Identities = 89/352 (25%), Positives = 116/352 (32%), Gaps = 73/352 (20%)
Query: 358 TKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGD 417
T + EWS WS CS TC G +VRTR+ P G+ P E PC +
Sbjct: 307 TGDPAAEEWSPWSVCSLTCGQ-----GLQVRTRSCVSSPYGTLCSGP-LRETRPC----N 356
Query: 418 GVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQL 477
C +G W E L S+ CG G ++R CV
Sbjct: 357 NSATCPVHG----VWEEWGSWSLCSRS----------CGRGSRSRMRTCVPPQHGG---- 398
Query: 478 STHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKG 537
K C GP T CP E + W WGPC+ N Q +
Sbjct: 399 --------------KACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRS- 443
Query: 538 FKLRKRRITNEP----TGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNG---- 589
RK + TG T C +L P + W A L + D G
Sbjct: 444 ---RKCSVAGPAWATCTGALTDTRECSNL--ECPATDSKWGPWNAWSLCSKTCDTGWQRR 498
Query: 590 -KECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCV-LSTWS------ 641
+ C T Q C GEEV + C + P A C + V L TW
Sbjct: 499 FRMC-QATGTQGYPC-EGTGEEV--KPCSEKRCP---AFHEMCRDEYVMLMTWKKAAAGE 551
Query: 642 -TWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEH 692
++ C SG + + A+ + AY G RC + S EH
Sbjct: 552 IIYNKCPPNASGSASRRCLLSAQGV-AYWGLPSFARCISHEYRYLYLSLREH 602
Score = 52.4 bits (124), Expect = 4e-06
Identities = 61/236 (25%), Positives = 84/236 (35%), Gaps = 41/236 (17%)
Query: 592 CGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCS 651
CG G QV+ C++S + R+ P A CP V W +WS CS +C
Sbjct: 325 CGQGLQVRTRSCVSSPYGTLCSGPLRETR---PCNNSATCPVHGVWEEWGSWSLCSRSC- 380
Query: 652 GKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVY-HW-QTGPWGQCIE 709
G+ R+R + GG C + + C+ C V W + GPWG C
Sbjct: 381 -----GRGSRSRMRTCVPPQHGGKACEGPEL--QTKLCSMAACPVEGQWLEWGPWGPC-- 431
Query: 710 DTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPC- 768
SC+ G Q R C +V C +L +T L C
Sbjct: 432 ---------------STSCANGTQQRSRKC---SVAGPAWATCTGAL-TDTRECSNLECP 472
Query: 769 KKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKAC 824
D P++ W+ C +C G Q R R + Q G C E K C
Sbjct: 473 ATDSKWGPWNAWSLCSKTCDTG-----WQRRFR-MCQATGTQGYPCEGTGEEVKPC 522
Score = 52.0 bits (123), Expect = 5e-06
Identities = 76/316 (24%), Positives = 107/316 (33%), Gaps = 73/316 (23%)
Query: 455 CGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCH--IPCPTE 512
CG G+Q R CV S P LC+GP+ T+ C+ CP
Sbjct: 325 CGQGLQVRTRSCV------------------SSPYGT-LCSGPL-RETRPCNNSATCPVH 364
Query: 513 CEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPA 572
W +W C+ +C +G + R R GG G P L + C A
Sbjct: 365 GVWEEWGSWSLCS-RSCG-----RGSRSRMRTCVPPQHGGKACEG--PELQTKL-CSMAA 415
Query: 573 C-YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPC 631
C + + + G P + C GTQ + C + C A+ + C
Sbjct: 416 CPVEGQWLEWGPWGPCS-TSCANGTQQRSRKCSVAGPAWAT---CTGALTDTRECSNLEC 471
Query: 632 PK-DCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN 690
P D W+ WS CS TC G Q R R A G +G P +EV+ C+
Sbjct: 472 PATDSKWGPWNAWSLCSKTCD----TGWQRRFRMCQA-TGTQG---YPCEGTGEEVKPCS 523
Query: 691 EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPK 750
E C +H + + TW A+ G++
Sbjct: 524 EKRCPAFH-----------EMCRDEYVMLMTWKKAAA-----------------GEIIYN 555
Query: 751 KCPESLRPETVRPCLL 766
KCP + R CLL
Sbjct: 556 KCPPNASGSASRRCLL 571
Score = 42.0 bits (97), Expect = 0.005
Identities = 47/199 (23%), Positives = 68/199 (34%), Gaps = 34/199 (17%)
Query: 727 SCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC--LLPCKKDCIVTPYSDWTSCP 784
+C G+Q R CV G + C LR RPC C + + W+ C
Sbjct: 324 TCGQGLQVRTRSCVSSPYGTL----CSGPLRE--TRPCNNSATCPVHGVWEEWGSWSLCS 377
Query: 785 SSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQ 844
SC G +SR R + P +GG+ C P + K C +W +W
Sbjct: 378 RSCGRGS-----RSRMRTCVP-PQHGGKACEGPELQTKLCSMAACPVEGQWL--EWG--- 426
Query: 845 LVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPC- 903
PW S C G Q R+ C A G + + + C
Sbjct: 427 --PWGPCSTS------CANGTQQRSRKCSVAGPAWA------TCTGALTDTRECSNLECP 472
Query: 904 QDDCQLTSWSKFSSCNGDC 922
D + W+ +S C+ C
Sbjct: 473 ATDSKWGPWNAWSLCSKTC 491
Score = 37.7 bits (86), Expect = 0.093
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 12/86 (13%)
Query: 1413 GDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDG 1472
GD ++WS WS+C LTC G+QVR+R + LC + ET+ C +
Sbjct: 308 GDPAAEEWSPWSVCSLTCGQ-------GLQVRTRSCVSSPYGT--LCSGPLRETRPCNNS 358
Query: 1473 QCYEYKWMASAWKGSSRTVWCQRSDG 1498
+ W S C RS G
Sbjct: 359 ATCPVHGVWEEWGSWS---LCSRSCG 381
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 75.5 bits (184), Expect = 4e-13
Identities = 74/258 (28%), Positives = 108/258 (41%), Gaps = 45/258 (17%)
Query: 1097 YLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPE-EMPLGS 1155
+ W +PWS C T C GVQ ++V C + + V++ CDP+ + P
Sbjct: 842 FTWNHQPWSECSAT-------CAGGVQRQEVVCKRL---DDNSIVQNNYCDPDSKPPENQ 891
Query: 1156 RVCKL-PCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQ--PADE------GRSCPN 1206
R C PCP + I G W +C C+ R R+ IR+ P++E G
Sbjct: 892 RACNTEPCPPEWFI---GDWLECSKTCD-GGMRTRAVLCIRKIGPSEEETLDYSGCLTHR 947
Query: 1207 AVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSD-GKSVDLKYCE 1265
VEKEPCN N++C + DWS C CG G K R++ C SD K+ C
Sbjct: 948 PVEKEPCN-NQSC-PPQWVALDWSEC----TPKCGPGFKHRIVLCKSSDLSKTFPAAQCP 1001
Query: 1266 ALGLEKNWQMNTSCMVECPV-NCQLSDW--SPWSECSQTCGLTGKMIRRRTVTQPFQGDG 1322
+ + C + C W W +CS CGL +M RTV Q G
Sbjct: 1002 E-------ESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQM---RTV-QCLSYTG 1050
Query: 1323 RPCPSLMDQSKPCPVKPC 1340
+ ++ +P ++ C
Sbjct: 1051 QASSDCLETVRPPSMQQC 1068
Score = 65.5 bits (158), Expect = 4e-10
Identities = 80/335 (23%), Positives = 132/335 (39%), Gaps = 69/335 (20%)
Query: 425 YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKE 484
+ W W+EC +A C GG+Q +EV C + ++N + Q + + + +
Sbjct: 842 FTWNHQPWSEC----------------SATCAGGVQRQEVVCKRLDDNSIVQ-NNYCDPD 884
Query: 485 ASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRR 544
+ P + + C NT PCP E + W C+ + + +RK
Sbjct: 885 SKPPENQRAC-----NTE-----PCPPEWFIGDWL---ECSKTCDGGMRTRAVLCIRKIG 931
Query: 545 ITNEPT-GGSGVTGNCPHLLEAIPCEEPAC-YDWKAVRLGNCEPDNGKECGPGTQVQEVV 602
+ E T SG + P +E PC +C W A+ C P +CGPG + + V+
Sbjct: 932 PSEEETLDYSGCLTHRP--VEKEPCNNQSCPPQWVALDWSECTP----KCGPGFKHRIVL 985
Query: 603 CINSDGEEV--DRQLCRDAIFPIPVACD-APCPKDCVLSTWST--WSSCSHTCSGKTTEG 657
C +SD + Q ++ P+ + C CP W T W CS C G
Sbjct: 986 CKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP----PRWVTGDWGQCSAQCG----LG 1037
Query: 658 KQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFN 717
+Q+R L+Y G+ +S L+ VR + C +C + T +S+
Sbjct: 1038 QQMRTVQCLSYTGQ------ASSDCLETVRPPSMQQCE---------SKC-DSTPISNTE 1081
Query: 718 TTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKC 752
N A C + ++ + C R Q+ K C
Sbjct: 1082 ECKDVNKVAYCPLVLKFK--FCSRAYFRQMCCKTC 1114
Score = 62.4 bits (150), Expect = 4e-09
Identities = 63/236 (26%), Positives = 92/236 (38%), Gaps = 63/236 (26%)
Query: 1173 PWTQCVLPC---------------NQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNK 1217
PW++C C + S + DP +P + R+C EPC
Sbjct: 848 PWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRAC----NTEPCPP-- 901
Query: 1218 NCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVD--LKYCEAL---GLEKN 1272
++ + DW C + C G++TR + C+R G S + L Y L +EK
Sbjct: 902 -----EWFIGDWLECSKT----CDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKE 952
Query: 1273 WQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGK----MIRRRTVTQPFQGDGRPCPSL 1328
N S CP D WSEC+ CG K + + +++ F P
Sbjct: 953 PCNNQS----CPPQWVALD---WSECTPKCGPGFKHRIVLCKSSDLSKTF-----PAAQC 1000
Query: 1329 MDQSKPCPVK--------PCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSA 1376
++SKP PV+ P RW G W C AQCG G + R + C+ G A
Sbjct: 1001 PEESKP-PVRIRCSLGRCPPPRWVTGDWGQC---SAQCGLGQQMRTVQCLSYTGQA 1052
Score = 58.5 bits (140), Expect = 5e-08
Identities = 69/260 (26%), Positives = 95/260 (36%), Gaps = 44/260 (16%)
Query: 1294 PWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMD-QSKP------CPVKPC-YRWQY 1345
PWSECS TC G + R+ V + + + D SKP C +PC W
Sbjct: 848 PWSECSATC--AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFI 905
Query: 1346 GQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNKNMVLEE 1405
G W C C G RTR + C+ G +++ + +D C V +E
Sbjct: 906 GDWLEC---SKTCDGGMRTRAVLCIRKIGPSEE--ETLDYSGCL--------THRPVEKE 952
Query: 1406 SC-SQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQHLCPEQML 1464
C +Q CP DWS C C GF V + + + CPE+
Sbjct: 953 PCNNQSCPPQWVALDWSE---CTPKC----GPGFKHRIVLCKSSDLSKTFPAAQCPEESK 1005
Query: 1465 ETK--SCYDGQCYEYKWMASAWKGSS---------RTVWCQRSDGINVTGGCLVMSQPDA 1513
C G+C +W+ W S RTV C G + CL +P +
Sbjct: 1006 PPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTG-QASSDCLETVRPPS 1064
Query: 1514 DRSCNPPC-SQPHSYCSETK 1532
+ C C S P S E K
Sbjct: 1065 MQQCESKCDSTPISNTEECK 1084
Score = 58.2 bits (139), Expect = 7e-08
Identities = 55/235 (23%), Positives = 90/235 (38%), Gaps = 32/235 (13%)
Query: 915 FSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCIL 974
+S C+ C G +++ CK +++ YC D ++P N C
Sbjct: 849 WSECSATCAG---------GVQRQEVVCKRLDDNSIVQNNYCDPD---SKPPENQRACNT 896
Query: 975 PEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNG----RLVETSRCNSHGYIEEACII 1030
E +G ++ K C G R +A+ C + G ++ S C +H +E+
Sbjct: 897 EPCPPEWFIGDWLECS-KTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKE--- 952
Query: 1031 PCPSDCKLSEWS--NWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVV 1088
PC + +W +WS C+ CG G K R + + P + ++ V +
Sbjct: 953 PCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR--I 1010
Query: 1089 PCH-SDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVE 1142
C C WVT W C CG G Q R V+C+ T S+ +E
Sbjct: 1011 RCSLGRCPPPRWVTGDWGQCSA-------QCGLGQQMRTVQCLSYTGQASSDCLE 1058
Score = 58.2 bits (139), Expect = 7e-08
Identities = 50/200 (25%), Positives = 68/200 (34%), Gaps = 35/200 (17%)
Query: 590 KECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWST--WSSCS 647
K C G + + V+CI G + L PC W WS C+
Sbjct: 913 KTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECT 972
Query: 648 HTCSGKTTEGKQIRARSILAYAGEEG----GIRCPNSSALQEVRSCNEHPCTVYHWQTGP 703
C G + R +L + + +CP S C+ C W TG
Sbjct: 973 PKC------GPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD 1026
Query: 704 WGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRP 763
WGQC A C +G Q R V C+ GQ C E++RP P
Sbjct: 1027 WGQC-----------------SAQCGLGQQMRTVQCLSY-TGQAS-SDCLETVRP----P 1063
Query: 764 CLLPCKKDCIVTPYSDWTSC 783
+ C+ C TP S+ C
Sbjct: 1064 SMQQCESKCDSTPISNTEEC 1083
Score = 56.2 bits (134), Expect = 3e-07
Identities = 60/279 (21%), Positives = 104/279 (37%), Gaps = 42/279 (15%)
Query: 51 GEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTN-CKQAERPNNQQ 109
G + + W PW C C GG+Q + V C ++ + + N C +P Q
Sbjct: 834 GSGDNEVGFTWNHQPWSECSAT-CA-GGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ 891
Query: 110 NCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPA 169
+ C+ +W +G W +C + G++ R + CI+K P+
Sbjct: 892 ---RACNTEPCPPEWFIGDWLECSKTC-------------DGGMRTRAVLCIRKIG--PS 933
Query: 170 EDIICEY---FEPKPLLEQACLIPCQQDCIVSEFSA--WSECSKTCGSGLQHR---TRHV 221
E+ +Y +P+ ++ PC ++ A WSEC+ CG G +HR +
Sbjct: 934 EEETLDYSGCLTHRPVEKE----PCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSS 989
Query: 222 VAPPQFGGSGCPNLTEFQV---CQSSPCEAEELRYSLHVGPWSTCSMP--HSRQVRQARR 276
F + CP ++ V C C G W CS +Q+R +
Sbjct: 990 DLSKTFPAAQCPEESKPPVRIRCSLGRCPPPR----WVTGDWGQCSAQCGLGQQMRTVQC 1045
Query: 277 RGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENK 315
+ D + V+ P ++ K + N +E K
Sbjct: 1046 LSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECK 1084
Score = 48.1 bits (113), Expect = 7e-05
Identities = 59/297 (19%), Positives = 100/297 (33%), Gaps = 76/297 (25%)
Query: 697 YHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKC--PE 754
+ W PW +C A+C+ G+Q ++V+C R++ + P+
Sbjct: 842 FTWNHQPWSEC-----------------SATCAGGVQRQEVVCKRLDDNSIVQNNYCDPD 884
Query: 755 SLRPETVRPCLL-PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRD 813
S PE R C PC + + DW C +C G R R ++ + G +
Sbjct: 885 SKPPENQRACNTEPCPPEWFI---GDWLECSKTCDGG-------MRTRAVLCIRKIGPSE 934
Query: 814 ---------CTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPG 864
T E++ C Q+C +W W C CGPG
Sbjct: 935 EETLDYSGCLTHRPVEKEPCNN-QSCPP-QWVALDWSECT--------------PKCGPG 978
Query: 865 RQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQL-----TSW--SKFSS 917
+ R + C+ D L P + + P + C L W +
Sbjct: 979 FKHRIVLCKSSD---------LSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQ 1029
Query: 918 CNGDCGAVRTRK--RTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDC 972
C+ CG + + + L + C + P ++ CD + P+ N +C
Sbjct: 1030 CSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCD---STPISNTEEC 1083
Score = 45.1 bits (105), Expect = 6e-04
Identities = 51/197 (25%), Positives = 70/197 (35%), Gaps = 27/197 (13%)
Query: 994 CGQGYRYQAMAC--YDQNGRLVETSRCNSHGYIEE---ACII-PCPSDCKLSEW--SNWS 1045
C G + Q + C D N +V+ + C+ E AC PCP EW +W
Sbjct: 856 CAGGVQRQEVVCKRLDDNS-IVQNNYCDPDSKPPENQRACNTEPCPP-----EWFIGDWL 909
Query: 1046 RCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWS 1105
CSK+C G++ R+ K + E PC++ WV WS
Sbjct: 910 ECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWS 969
Query: 1106 ICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKL-PCPE 1164
C CG G + R V C + S+ C E P C L CP
Sbjct: 970 EC-------TPKCGPGFKHRIVLCKSSDL---SKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
Query: 1165 DCVISEWGPWTQCVLPC 1181
++ G W QC C
Sbjct: 1020 PRWVT--GDWGQCSAQC 1034
Score = 42.7 bits (99), Expect = 0.003
Identities = 47/178 (26%), Positives = 66/178 (37%), Gaps = 41/178 (23%)
Query: 322 GYQTREVMCINKTGKA-ADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHD 378
G Q +EV+C + ++C + P Q T+ C EW +W CSKTC
Sbjct: 859 GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP-PEWFIGDWLECSKTC-- 915
Query: 379 MVSPAGTRVRTRTIRQFPIGSEKECPEFE--------EKEPCLSQGDGVVPCATYGWRTT 430
G R R + SE+E ++ EKEPC +Q C W
Sbjct: 916 ---DGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS-----CPPQ-WVAL 966
Query: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKP 488
+W+EC T CG G + R V C + +L + E SKP
Sbjct: 967 DWSEC----------------TPKCGPGFKHRIVLC--KSSDLSKTFPAAQCPEESKP 1006
Score = 42.7 bits (99), Expect = 0.003
Identities = 48/193 (24%), Positives = 71/193 (36%), Gaps = 39/193 (20%)
Query: 322 GYQTREVMCINKTG----KAADLSFC----QQEKLPMTFQSCVITKECQVSEW--SEWSP 371
G +TR V+CI K G + D S C EK P QSC +W +WS
Sbjct: 918 GMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSC-------PPQWVALDWSE 970
Query: 372 CSKTCHDMVSPAGTRVRTRTI-RQFPIGSEKECPEFEEKEPCLSQGDGVVPCATYGWRTT 430
C+ C ++ + + FP +CP EE +P + + C W T
Sbjct: 971 CTPKCGPGFKHRIVLCKSSDLSKTFPAA---QCP--EESKPPVRIRCSLGRCPPPRWVTG 1025
Query: 431 EWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMD 490
+W +C +A CG G Q R V C+ S + + +
Sbjct: 1026 DWGQC----------------SAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCE 1069
Query: 491 LKLCTGPIPNTTQ 503
K + PI NT +
Sbjct: 1070 SKCDSTPISNTEE 1082
Score = 42.0 bits (97), Expect = 0.005
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 2/49 (4%)
Query: 200 FSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGC-PNLTEFQVCQSSPC 246
+S W ECS+TCG G+ RH +P P GG C ++ C + PC
Sbjct: 564 WSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
Score = 39.3 bits (90), Expect = 0.032
Identities = 23/94 (24%), Positives = 36/94 (38%), Gaps = 4/94 (4%)
Query: 1251 CVRSDGKSVDLKYCEALGLEKNWQMNTSCMV----ECPVNCQLSDWSPWSECSQTCGLTG 1306
CV + + + C+ +EK W C+ ++ WS W ECS+TCG
Sbjct: 519 CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGV 578
Query: 1307 KMIRRRTVTQPFQGDGRPCPSLMDQSKPCPVKPC 1340
R + G G+ C + + C PC
Sbjct: 579 SSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
Score = 34.3 bits (77), Expect = 1.0
Identities = 20/55 (36%), Positives = 22/55 (40%), Gaps = 6/55 (10%)
Query: 640 WSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
WS W CS TC G G R + A GG C + RSCN PC
Sbjct: 564 WSLWGECSRTCGG----GVSSSLRHCDSPAPSGGGKYCLGER--KRYRSCNTDPC 612
Score = 31.2 bits (69), Expect = 8.7
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 7/37 (18%)
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLRE----KPYNGGRPC 1073
WS W CS++CG GV S LR P GG+ C
Sbjct: 564 WSLWGECSRTCGGGV---SSSLRHCDSPAPSGGGKYC 597
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 74.7 bits (182), Expect = 7e-13
Identities = 75/295 (25%), Positives = 111/295 (37%), Gaps = 64/295 (21%)
Query: 621 FPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRA---RSILAYAGEEGGIRC 677
F P+A D+ P ++ W+ CS C+G G Q++A R+ L +
Sbjct: 815 FNAPIARDSLPPYSW---HYAPWTKCSAQCAG----GSQVQAVECRNQLDSSAVAPHYCS 867
Query: 678 PNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKV 737
+S + R+CN PC W G W C SC G+++R V
Sbjct: 868 AHSKLPKRQRACNTEPCPP-DWVVGNWSLC-----------------SRSCDAGVRSRSV 909
Query: 738 ICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYS--DWTSCPSSCKEGDSSIR 795
+C R V K +S P+ P L C ++ DW+ C SC G
Sbjct: 910 VCQR-RVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPG----- 963
Query: 796 KQSRHRVIIQLPANGGRDCTDPLYEEKACEAP-------QACQSYRWKTHKWRRCQLVPW 848
RHRV++ A+ R P + A + P + C RW +W C
Sbjct: 964 --LRHRVVLCKSADH-RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECS---- 1016
Query: 849 SVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPC 903
AQ CG G++ R++ C G + HEC + P TQ C+ C
Sbjct: 1017 --------AQ--CGVGQRQRSVRCTSHTGQAS--HECTEALR--PPTTQQCEAKC 1057
Score = 64.7 bits (156), Expect = 7e-10
Identities = 59/225 (26%), Positives = 84/225 (37%), Gaps = 28/225 (12%)
Query: 993 ECGQGYRYQAMACYDQ-NGRLVETSRCNSHGYI---EEACII-PCPSDCKLSEWSNWSRC 1047
+C G + QA+ C +Q + V C++H + + AC PCP D + NWS C
Sbjct: 840 QCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVG---NWSLC 896
Query: 1048 SKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSIC 1107
S+SC +GV+ RS + + Q + + CH W WS C
Sbjct: 897 SRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSEC 956
Query: 1108 KVTFVNMRENCGEGVQTRKVRC--MQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPED 1165
+CG G++ R V C + A P H C P P + C L
Sbjct: 957 -------TPSCGPGLRHRVVLCKSADHRATLPPAH-----CSPAAKPPATMRCNL---RR 1001
Query: 1166 CVISEW--GPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAV 1208
C + W G W +C C RQRS C A+
Sbjct: 1002 CPPARWVAGEWGECSAQCGVGQ-RQRSVRCTSHTGQASHECTEAL 1045
Score = 63.9 bits (154), Expect = 1e-09
Identities = 53/210 (25%), Positives = 77/210 (36%), Gaps = 45/210 (21%)
Query: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCIN----SDGEEVDRQLCRDAIFPIPV 625
EP DW C + C G + + VVC ++ + +D C P+
Sbjct: 882 EPCPPDWVVGNWSLCS----RSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLE 937
Query: 626 ACDAP-CPKDCVLSTWST--WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI----RCP 678
AC P CP + W+ WS C+ +C G +R R +L + + C
Sbjct: 938 ACHGPTCPPE-----WAALDWSECTPSC------GPGLRHRVVLCKSADHRATLPPAHCS 986
Query: 679 NSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVI 738
++ CN C W G WG+C A C VG + R V
Sbjct: 987 PAAKPPATMRCNLRRCPPARWVAGEWGEC-----------------SAQCGVGQRQRSVR 1029
Query: 739 CVRVNVGQVGPKKCPESLRPETVRPCLLPC 768
C + GQ +C E+LRP T + C C
Sbjct: 1030 CTS-HTGQAS-HECTEALRPPTTQQCEAKC 1057
Score = 60.1 bits (144), Expect = 2e-08
Identities = 70/273 (25%), Positives = 97/273 (35%), Gaps = 68/273 (24%)
Query: 1171 WGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPN-------------AVEKEPCNLNK 1217
+ PWT+C C S Q A R D P+ A EPC
Sbjct: 831 YAPWTKCSAQCAGGS--QVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP-- 886
Query: 1218 NCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVR----SDGKSVDLKYCEALGLEKNW 1273
D+ V +WS C S C G+++R + C R ++ K++D C
Sbjct: 887 -----DWVVGNWSLCSRS----CDAGVRSRSVVCQRRVSAAEEKALDDSACP-------- 929
Query: 1274 QMNTSCMVECPVNCQLSDWSP--WSECSQTCGLTGKMIRRRTVTQPFQGDGR---PCPSL 1328
Q + C +W+ WSEC+ +CG +R R V D R P
Sbjct: 930 QPRPPVLEACHGPTCPPEWAALDWSECTPSCG---PGLRHRVVLCK-SADHRATLPPAHC 985
Query: 1329 MDQSKP-----CPVKPC--YRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSK 1381
+KP C ++ C RW G+W C AQCG G R R++ C G A
Sbjct: 986 SPAAKPPATMRCNLRRCPPARWVAGEWGECS---AQCGVGQRQRSVRCTSHTGQA----- 1037
Query: 1382 VVDEEFCADIELIIDGNKNMVLEESCSQPCPGD 1414
C + + E C P PGD
Sbjct: 1038 ---SHECTE---ALRPPTTQQCEAKCDSPTPGD 1064
Score = 56.2 bits (134), Expect = 3e-07
Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 40/170 (23%)
Query: 59 YLWKTGPWGRCMGDECGPGGIQTRAVWC-------AHVEGWTTLHTNCKQAERPNNQQNC 111
Y W PW +C +C GG Q +AV C A + + H+ + +R N + C
Sbjct: 827 YSWHYAPWTKCSA-QCA-GGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 112 FKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIAC---IQKDKDIP 168
DW +G W+ C S+S + G++ R + C + ++
Sbjct: 885 PP---------DWVVGNWSLC----SRSCDA---------GVRSRSVVCQRRVSAAEEKA 922
Query: 169 AEDIICEYFEPKPLLEQACLIP-CQQDCIVSEFSAWSECSKTCGSGLQHR 217
+D C +P+P + +AC P C + + WSEC+ +CG GL+HR
Sbjct: 923 LDDSACP--QPRPPVLEACHGPTCPPEWAALD---WSECTPSCGPGLRHR 967
Score = 55.8 bits (133), Expect = 3e-07
Identities = 54/229 (23%), Positives = 89/229 (38%), Gaps = 33/229 (14%)
Query: 1041 WSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWV 1100
++ W++CS C G +V++ R + + P + C+++ WV
Sbjct: 831 YAPWTKCSAQCAGGSQVQAVECRNQ-LDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
Query: 1101 TEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKL 1160
WS+C +C GV++R V C + + + ++D C P+ P C
Sbjct: 890 VGNWSLCS-------RSCDAGVRSRSVVCQRRVSAAEEKALDDSAC-PQPRPPVLEACHG 941
Query: 1161 P-CPEDCVISEWG--PWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA----VEKEP- 1212
P CP EW W++C C R R + + AD + P A K P
Sbjct: 942 PTCP-----PEWAALDWSECTPSCG-PGLRHRVV--LCKSADHRATLPPAHCSPAAKPPA 993
Query: 1213 ---CNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKS 1258
CNL + C + +W C A CG G + R + C G++
Sbjct: 994 TMRCNL-RRCPPARWVAGEWGEC----SAQCGVGQRQRSVRCTSHTGQA 1037
Score = 51.2 bits (121), Expect = 8e-06
Identities = 68/275 (24%), Positives = 96/275 (34%), Gaps = 58/275 (21%)
Query: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINS-DGEEVDRQLCRDAIFPIPV---ACDA 629
Y W C +C G+QVQ V C N D V C A +P AC+
Sbjct: 827 YSWHYAPWTKCSA----QCAGGSQVQAVECRNQLDSSAVAPHYC-SAHSKLPKRQRACNT 881
Query: 630 -PCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAY----AGEEGGI---RCPNSS 681
PCP D V+ WS CS +C +R+RS++ A EE + CP
Sbjct: 882 EPCPPDWVVGNWSL---CSRSCDA------GVRSRSVVCQRRVSAAEEKALDDSACPQPR 932
Query: 682 ALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVR 741
+ +C+ C W W +C SC G++ R V+C
Sbjct: 933 P-PVLEACHGPTCPP-EWAALDWSEC-----------------TPSCGPGLRHRVVLCKS 973
Query: 742 V-NVGQVGPKKC-PESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSSCKEG--DSSIRKQ 797
+ + P C P + P T+R L C V +W C + C G S+R
Sbjct: 974 ADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVA--GEWGECSAQCGVGQRQRSVRCT 1031
Query: 798 SRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQS 832
S +CT+ L + C S
Sbjct: 1032 SH-------TGQASHECTEALRPPTTQQCEAKCDS 1059
Score = 50.8 bits (120), Expect = 1e-05
Identities = 58/250 (23%), Positives = 89/250 (35%), Gaps = 62/250 (24%)
Query: 697 YHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICV-RVNVGQVGPKKCP-E 754
Y W PW +C A C+ G Q + V C +++ V P C
Sbjct: 827 YSWHYAPWTKC-----------------SAQCAGGSQVQAVECRNQLDSSAVAPHYCSAH 869
Query: 755 SLRPETVRPCLL-PCKKDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRD 813
S P+ R C PC D +V +W+ C SC D+ +R +S V+ Q + +
Sbjct: 870 SKLPKRQRACNTEPCPPDWVV---GNWSLCSRSC---DAGVRSRS---VVCQRRVSAAEE 920
Query: 814 CTDPLYEEKACEAP-----QACQSY----RWKTHKWRRCQLVPWSVQQDSPGAQEGCGPG 864
++ AC P +AC W W C CGPG
Sbjct: 921 ---KALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECT--------------PSCGPG 963
Query: 865 RQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDC 922
+ R + C+ D +A + P T C + C W ++ C+ C
Sbjct: 964 LRHRVVLCKSAD-HRATLPPAHCSPAAKPPATMRCNL---RRCPPARWVAGEWGECSAQC 1019
Query: 923 GAVRTRKRTL 932
G V R+R++
Sbjct: 1020 G-VGQRQRSV 1028
Score = 50.1 bits (118), Expect = 2e-05
Identities = 63/256 (24%), Positives = 94/256 (36%), Gaps = 50/256 (19%)
Query: 425 YGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKE 484
Y W WT+C +A C GG Q + V C N+ S ++ H
Sbjct: 827 YSWHYAPWTKC----------------SAQCAGGSQVQAVEC--RNQLDSSAVAPHYCSA 868
Query: 485 ASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKR 543
SK +P + C+ PCP + V WS C+ +C+ + ++R
Sbjct: 869 HSK----------LPKRQRACNTEPCPPDWVVGNWSL---CS-RSCDAGVRSRSVVCQRR 914
Query: 544 RITNEPTG--GSGVTGNCPHLLEAIPCEEPAC-YDWKAVRLGNCEPDNGKECGPGTQVQE 600
E S P +LEA C P C +W A+ C P CGPG + +
Sbjct: 915 VSAAEEKALDDSACPQPRPPVLEA--CHGPTCPPEWAALDWSECTP----SCGPGLRHRV 968
Query: 601 VVCINSDGE-EVDRQLCRDAIF-PIPVACDAPCPKDCVLSTW--STWSSCSHTCSGKTTE 656
V+C ++D + C A P + C+ + C + W W CS C G
Sbjct: 969 VLCKSADHRATLPPAHCSPAAKPPATMRCNL---RRCPPARWVAGEWGECSAQC-GVGQR 1024
Query: 657 GKQIRARSILAYAGEE 672
+ +R S A E
Sbjct: 1025 QRSVRCTSHTGQASHE 1040
Score = 48.5 bits (114), Expect = 5e-05
Identities = 57/250 (22%), Positives = 85/250 (34%), Gaps = 39/250 (15%)
Query: 122 YDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKP 181
Y W PW +C +C G QV+ + C + C P
Sbjct: 827 YSWHYAPWTKCSA----------QCAGGS---QVQAVECRNQLDSSAVAPHYCSAHSKLP 873
Query: 182 LLEQACLI-PCQQDCIVSEFSAWSECSKTCGSGLQHRT----RHVVAPPQ--FGGSGCPN 234
++AC PC D +V WS CS++C +G++ R+ R V A + S CP
Sbjct: 874 KRQRACNTEPCPPDWVVGN---WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ 930
Query: 235 LTE--FQVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVK 292
+ C C E WS C+ +R K+ +
Sbjct: 931 PRPPVLEACHGPTCPPEWAALD-----WSECTPSCGPGLRHRVVLCKSADHRATLPPAHC 985
Query: 293 DPEARELIKKKRNRNR--QNRQENKYW-----DIQIGYQTREVMCINKTGKAADLSFCQQ 345
P A+ + N R R W +G + R V C + TG+A+ C +
Sbjct: 986 SPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQAS--HECTE 1043
Query: 346 EKLPMTFQSC 355
P T Q C
Sbjct: 1044 ALRPPTTQQC 1053
Score = 46.6 bits (109), Expect = 2e-04
Identities = 48/200 (24%), Positives = 73/200 (36%), Gaps = 46/200 (23%)
Query: 1339 PCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGN 1398
P Y W Y W+ C AQC G++ + + C D S V +C+ +
Sbjct: 825 PPYSWHYAPWTKC---SAQCAGGSQVQAVEC---RNQLD--SSAVAPHYCS------AHS 870
Query: 1399 KNMVLEESC-SQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQ------ 1451
K + +C ++PCP D + +WSLC +C G VRSR V+ Q
Sbjct: 871 KLPKRQRACNTEPCPPDWVV---GNWSLCSRSCDAG---------VRSRSVVCQRRVSAA 918
Query: 1452 --ELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSS---------RTVWCQRSD--G 1498
+ + CP+ G +W A W + R V C+ +D
Sbjct: 919 EEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRA 978
Query: 1499 INVTGGCLVMSQPDADRSCN 1518
C ++P A CN
Sbjct: 979 TLPPAHCSPAAKPPATMRCN 998
Score = 42.0 bits (97), Expect = 0.005
Identities = 65/287 (22%), Positives = 95/287 (33%), Gaps = 71/287 (24%)
Query: 366 WSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEF---EEKEPCLSQGDGVVPC 422
++ W+ CS C G++V+ R + S P + K P + PC
Sbjct: 831 YAPWTKCSAQC-----AGGSQVQAVECRN-QLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 423 ATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKN 482
W W+ C + C G+++R V C + +
Sbjct: 885 PP-DWVVGNWSLC----------------SRSCDAGVRSRSVVCQR-----------RVS 916
Query: 483 KEASKPMDLKLCTGPIPNTTQLCHIP-CPTECEVSPWSA--WGPCTYENCNDQQGKKGF- 538
K +D C P P + CH P CP E W+A W CT +C +
Sbjct: 917 AAEEKALDDSACPQPRPPVLEACHGPTCPPE-----WAALDWSECT-PSCGPGLRHRVVL 970
Query: 539 -KLRKRRITNEPTGGS-----GVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC 592
K R T P S T C +L P W A G C +C
Sbjct: 971 CKSADHRATLPPAHCSPAAKPPATMRC-NLRRCPPAR------WVAGEWGEC----SAQC 1019
Query: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFP-----IPVACDAPCPKD 634
G G + + V C + G+ C +A+ P CD+P P D
Sbjct: 1020 GVGQRQRSVRCTSHTGQASHE--CTEALRPPTTQQCEAKCDSPTPGD 1064
Score = 37.0 bits (84), Expect = 0.16
Identities = 14/34 (41%), Positives = 21/34 (61%), Gaps = 1/34 (2%)
Query: 200 FSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGC 232
++ W +CS+TCG G+ +RH +P P GG C
Sbjct: 553 WTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYC 586
Score = 35.4 bits (80), Expect = 0.46
Identities = 21/56 (37%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 61 WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCD 116
W G WG C +CG G Q R+V C G + C +A RP Q C CD
Sbjct: 1007 WVAGEWGECSA-QCGVGQRQ-RSVRCTSHTGQAS--HECTEALRPPTTQQCEAKCD 1058
Score = 34.3 bits (77), Expect = 1.0
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 17/99 (17%)
Query: 992 KECGQGYRYQAMACYDQNGRLV-------ETSRCNSH----GYIEEACIIPCPS-----D 1035
++C G + C ++ R + E + C +H G+ + +P S D
Sbjct: 488 RQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVD 547
Query: 1036 CKLSEWSNWSRCSKSCGSGVKVRSKWL-REKPYNGGRPC 1073
W+ W CS++CG GV S+ +P GG+ C
Sbjct: 548 GAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYC 586
Score = 32.7 bits (73), Expect = 3.0
Identities = 14/57 (24%), Positives = 26/57 (45%), Gaps = 4/57 (7%)
Query: 1251 CVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECP----VNCQLSDWSPWSECSQTCG 1303
C+ + + + C+ ++K W C+ V+ W+PW +CS+TCG
Sbjct: 508 CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCG 564
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 71.2 bits (173), Expect = 8e-12
Identities = 65/283 (22%), Positives = 99/283 (34%), Gaps = 37/283 (13%)
Query: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWS--NWSRCSKSC 1051
CG G CY V S CN ++PC WS NWS CS++C
Sbjct: 885 CGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTG-LVPCKVSACPPSWSVGNWSACSRTC 943
Query: 1052 GSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTF 1111
G G + R + + P P Q C+S W PW+ C T
Sbjct: 944 GGGAQSRPVQCTRRVHYDSEPVP-ASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHT- 1001
Query: 1112 VNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEW 1171
CG+G + R V C ++ + D +C E P C L +W
Sbjct: 1002 ------CGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQW 1055
Query: 1172 --GPWTQCVLPCNQSSFRQ------------------RSADPIRQPADE-GRSC-PNAVE 1209
W+QC + C + + ++ + + +P+ E R+C P
Sbjct: 1056 LVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCP 1115
Query: 1210 KEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCV 1252
+ P + + WS C S CG G++TR + C+
Sbjct: 1116 RHPPFAAAGPSRGSWFASPWSQCTAS----CGGGVQTRSVQCL 1154
Score = 70.5 bits (171), Expect = 1e-11
Identities = 82/338 (24%), Positives = 124/338 (36%), Gaps = 55/338 (16%)
Query: 1229 WSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQ 1288
W+ + CG G T C R V++ +C + +V C V+
Sbjct: 874 WAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPK------TRPVTGLVPCKVSAC 927
Query: 1289 LSDWSP--WSECSQTCGLTGKMIRRRTVTQPFQGDGRPCP-SLMDQSKPCPVKPCYR--- 1342
WS WS CS+TCG G R T+ D P P SL Q P + C
Sbjct: 928 PPSWSVGNWSACSRTCG-GGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSC 986
Query: 1343 ---WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNK 1399
W G W+ C CG+G R R ++C ++ SA ++++ + C K
Sbjct: 987 PPAWSAGPWAECS---HTCGKGWRKRAVACKSTNPSAR--AQLLPDAVCTSEP------K 1035
Query: 1400 NMVLEESCSQPCPGDCYLKDW--SSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQELENQ- 1456
+ E Q C L+ W S+WS C +TC G F + +EL ++
Sbjct: 1036 PRMHEACLLQRCHKPKKLQ-WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKK 1094
Query: 1457 --HLCPEQMLETKSCYDGQCYEY-----------KWMASAWK-------GSSRTVWCQRS 1496
HL + ++C C + W AS W G +T Q
Sbjct: 1095 CSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL 1154
Query: 1497 DGINVTGGCLVMSQPDADRSCN----PPCSQPHSYCSE 1530
G GCL+ +P A +CN P + ++C +
Sbjct: 1155 AGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKD 1192
Score = 65.9 bits (159), Expect = 3e-10
Identities = 73/309 (23%), Positives = 113/309 (36%), Gaps = 78/309 (25%)
Query: 861 CGPGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWS--KFSSC 918
CG G+ C + Q + C PV L +PC+ SWS +S+C
Sbjct: 885 CGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGL-----VPCKVSACPPSWSVGNWSAC 939
Query: 919 NGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPL--IETQYCP---------CDKYNAQPV- 966
+ CG G + +C Y + CP C+ + P
Sbjct: 940 SRTCGG---------GAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAW 990
Query: 967 --GNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQN----GRLVETSRCNS 1020
G W++C CG+G+R +A+AC N +L+ + C S
Sbjct: 991 SAGPWAECS------------------HTCGKGWRKRAVACKSTNPSARAQLLPDAVCTS 1032
Query: 1021 HGY--IEEACIIPCPSDCKLSEW--SNWSRCSKSCGSGVKVRSKWLREKPYNG------G 1070
+ EAC++ K +W S WS+CS +C G + R EK +G
Sbjct: 1033 EPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELAS 1092
Query: 1071 RPCPKLDH--VNQAQVYEVVPCH-------SDCNQYLWVTEPWSICKVTFVNMRENCGEG 1121
+ C L + + +PC + ++ W PWS C + CG G
Sbjct: 1093 KKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTAS-------CGGG 1145
Query: 1122 VQTRKVRCM 1130
VQTR V+C+
Sbjct: 1146 VQTRSVQCL 1154
Score = 61.6 bits (148), Expect = 6e-09
Identities = 85/373 (22%), Positives = 122/373 (32%), Gaps = 78/373 (20%)
Query: 564 EAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPI 623
E P +P+ Y W VR + CG G C +V+ C P+
Sbjct: 863 EKQPPAQPS-YTWAIVR-----SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPV 916
Query: 624 PVACDAPCPKDCVLSTWST--WSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSS 681
PC +WS WS+CS TC G + + ++ + Y E
Sbjct: 917 TGL--VPCKVSACPPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLCPQP 973
Query: 682 ALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVR 741
A ++CN C W GPW +C +C G + R V C
Sbjct: 974 APSSRQACNSQSCPP-AWSAGPWAEC-----------------SHTCGKGWRKRAVACKS 1015
Query: 742 VNV---GQVGPKK-CPESLRPETVRPCLL-----PCKKDCIVTPYSDWTSCPSSCKEG-D 791
N Q+ P C +P CLL P K +V S W+ C +C+ G
Sbjct: 1016 TNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV---SAWSQCSVTCERGTQ 1072
Query: 792 SSIRKQSRHRVIIQLPANGGRDCT----DPLYEEKACEAPQACQSY-----------RWK 836
K + V + + C+ L E+AC AP C + W
Sbjct: 1073 KRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERAC-APLPCPRHPPFAAAGPSRGSWF 1131
Query: 837 THKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQDGGQAGIHECLQYAGPVPAL- 895
W +C CG G Q R++ C +G CL + P +L
Sbjct: 1132 ASPWSQC--------------TASCGGGVQTRSVQCLAGGRPASG---CLLHQKPSASLA 1174
Query: 896 --TQACQIPCQDD 906
T C I + D
Sbjct: 1175 CNTHFCPIAEKKD 1187
Score = 60.1 bits (144), Expect = 2e-08
Identities = 81/342 (23%), Positives = 117/342 (34%), Gaps = 82/342 (23%)
Query: 1045 SRCSKSCGSG-VKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEP 1103
S CS SCG G + VR R+ + + V +VPC W
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNM---SFCNPKTRPVTGLVPCKVSACPPSWSVGN 935
Query: 1104 WSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLP-C 1162
WS C T CG G Q+R V+C + SE V LC P+ P + C C
Sbjct: 936 WSACSRT-------CGGGAQSRPVQCTRRV-HYDSEPVPASLC-PQPAPSSRQACNSQSC 986
Query: 1163 PEDCVISEW--GPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNAVEKEPCNLNKNCY 1220
P W GPW +C C + ++ A P+
Sbjct: 987 PP-----AWSAGPWAECSHTCGKGWRKRAVACKSTNPS---------------------- 1019
Query: 1221 HYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
+ QL AVC + K RM + L+ C K Q S
Sbjct: 1020 ---------ARAQLLPDAVCTSEPKPRMHEACL-------LQRCHK---PKKLQWLVSAW 1060
Query: 1281 VECPVNCQLSDWSPWSECSQ--TCGLTGKMIRRRT--VTQPFQGDGRPCPSLMDQSKPCP 1336
+C V C+ + +C++ G ++ ++ + +P R C L PCP
Sbjct: 1061 SQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPL-----PCP 1115
Query: 1337 VKPCYR--------WQYGQWSPCQVQEAQCGEGTRTRNISCV 1370
P + W WS C A CG G +TR++ C+
Sbjct: 1116 RHPPFAAAGPSRGSWFASPWSQCT---ASCGGGVQTRSVQCL 1154
Score = 58.5 bits (140), Expect = 5e-08
Identities = 70/314 (22%), Positives = 101/314 (32%), Gaps = 84/314 (26%)
Query: 418 GVVPCATYG----WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENL 473
G+VPC W W+ C + CGGG Q+R V C
Sbjct: 918 GLVPCKVSACPPSWSVGNWSAC----------------SRTCGGGAQSRPVQC------- 954
Query: 474 LSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHI-PCPTECEVSPWSAWGPCTYENCNDQ 532
T + S+P+ LC P P++ Q C+ CP PW+ C+
Sbjct: 955 -----TRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWA--------ECSHT 1001
Query: 533 QGKKGFKLRKRRITNEPTGGSG----------VTGNCPHLLEAI---PCEEPACYDWKAV 579
GK RKR + + T S + P + EA C +P W
Sbjct: 1002 CGK---GWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVS 1058
Query: 580 RLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIP--------VACDAPC 631
C C GTQ + + C R+L +P PC
Sbjct: 1059 AWSQC----SVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
Query: 632 PKDCVLS-------TW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSA 682
P+ + +W S WS C+ +C G ++ RS+ AG C
Sbjct: 1115 PRHPPFAAAGPSRGSWFASPWSQCTASCGG------GVQTRSVQCLAGGRPASGCLLHQK 1168
Query: 683 LQEVRSCNEHPCTV 696
+CN H C +
Sbjct: 1169 PSASLACNTHFCPI 1182
Score = 56.6 bits (135), Expect = 2e-07
Identities = 65/253 (25%), Positives = 98/253 (38%), Gaps = 64/253 (25%)
Query: 1224 YNVTDWSTCQLSEKAVCGNGIKTRMLDCVRS---DGKSVDLKYCEALGLEKNWQMNTSCM 1280
++V +WS C + CG G ++R + C R D + V C N+
Sbjct: 931 WSVGNWSACSRT----CGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQ-- 984
Query: 1281 VECPVNCQLSDWS--PWSECSQTCGLTGKMIRRRTV----TQPFQGDGRPCPSLMDQSKP 1334
CP WS PW+ECS TC GK R+R V T P + P + S+P
Sbjct: 985 -SCP-----PAWSAGPWAECSHTC---GKGWRKRAVACKSTNP-SARAQLLPDAVCTSEP 1034
Query: 1335 -------CPVKPCYR-----WQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKV 1382
C ++ C++ W WS C V C GT+ R + C ++ +
Sbjct: 1035 KPRMHEACLLQRCHKPKKLQWLVSAWSQCSV---TCERGTQKRFLKC--AEKYVSGKYRE 1089
Query: 1383 VDEEFCADIELIIDGNKNMVLEESCSQ-PCP-------GDCYLKDW--SSWSLCQLTCVN 1432
+ + C+ + ++ LE +C+ PCP W S WS C +C
Sbjct: 1090 LASKKCSHLP-----KPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASC-- 1142
Query: 1433 GEDLGFGGIQVRS 1445
GG+Q RS
Sbjct: 1143 -----GGGVQTRS 1150
Score = 55.8 bits (133), Expect = 3e-07
Identities = 69/332 (20%), Positives = 107/332 (32%), Gaps = 95/332 (28%)
Query: 188 LIPCQQDCIVSEFSA--WSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSS- 244
L+PC+ +S WS CS+TCG G Q R + P Q SS
Sbjct: 919 LVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSR 978
Query: 245 -PCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKK 303
C ++ + GPW+ CS GK + K +L+
Sbjct: 979 QACNSQSCPPAWSAGPWAECS----------HTCGKGWRKRAVACKSTNPSARAQLLPD- 1027
Query: 304 RNRNRQNRQENKYWDIQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITK--EC 361
+ C E P ++C++ + +
Sbjct: 1028 -------------------------------------AVCTSEPKPRMHEACLLQRCHKP 1050
Query: 362 QVSEW--SEWSPCSKTCHDMVSPAGTRVR-TRTIRQFPIG-----SEKECPEFEEKEPCL 413
+ +W S WS CS TC GT+ R + ++ G + K+C + L
Sbjct: 1051 KKLQWLVSAWSQCSVTCE-----RGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLEL 1105
Query: 414 SQGDGVVPCATY-----------GWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTR 462
+ +PC + W + W++C TA CGGG+QTR
Sbjct: 1106 ERACAPLPCPRHPPFAAAGPSRGSWFASPWSQC----------------TASCGGGVQTR 1149
Query: 463 EVYCVQANENLLSQLSTHKNKEASKPMDLKLC 494
V C+ A S H+ AS + C
Sbjct: 1150 SVQCL-AGGRPASGCLLHQKPSASLACNTHFC 1180
Score = 54.7 bits (130), Expect = 7e-07
Identities = 145/641 (22%), Positives = 220/641 (34%), Gaps = 139/641 (21%)
Query: 508 PCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITN-EPTGGSGVTGNCPHLLEAI 566
P PT S WS+W PC+ C G R R TN +P+ G L+
Sbjct: 582 PKPTHGHWSDWSSWSPCS-RTCGG-----GVSHRSRLCTNPKPSHGGKFCEGSTRTLKL- 634
Query: 567 PCEEPAC-YDWKAVRLGNCEPDNGK-------ECGPGTQVQE-----VVCINS------- 606
C C D R C N + + P TQV++ + CI
Sbjct: 635 -CNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFS 693
Query: 607 ------DG---EEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCS---GKT 654
DG E R +C D I V CD D V + + C+ G
Sbjct: 694 LSNKVKDGTPCSEDSRNVCIDGICE-RVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLY 752
Query: 655 TEGKQIR-----------ARSILAYAGEEGGIRCPNSSALQEVRSCNEHPCTVYHWQTGP 703
T+ ARSI Y S++ VR+ HW
Sbjct: 753 TKHHHTNQYYHMVTIPSGARSIRIYEMNV-------STSYISVRNALRRYYLNGHWTVDW 805
Query: 704 WGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRP 763
G+ S ++F+ ++N + T + + V + P E P
Sbjct: 806 PGRY--KFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPR---- 859
Query: 764 CLLPCKKDCIVTPYSDW----TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLY 819
L +K P W + C SC G ++R+ + Q+ + T P+
Sbjct: 860 --LGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVT 917
Query: 820 EEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQ---D 876
C+ AC W W C CG G Q+R + C ++ D
Sbjct: 918 GLVPCKV-SACPP-SWSVGNWSACSRT--------------CGGGAQSRPVQCTRRVHYD 961
Query: 877 GGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSK--FSSCNGDCGAVRTRKRTLVG 934
C Q P P+ QAC C +WS ++ C+ CG G
Sbjct: 962 SEPVPASLCPQ---PAPSSRQACN---SQSCP-PAWSAGPWAECSHTCGK---------G 1005
Query: 935 KSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSD-CILPE----GKVEVLLGMKVQG 989
K+ CK+++ P Q P ++P + C+L K++ L+ Q
Sbjct: 1006 WRKRAVACKSTN--PSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQC 1063
Query: 990 DIKECGQGYRYQAMACYDQ--NGRLVE-TSRCNSHG-----YIEEACI-IPCPSDCKLS- 1039
+ C +G + + + C ++ +G+ E S+ SH +E AC +PCP +
Sbjct: 1064 SVT-CERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAA 1122
Query: 1040 ------EW--SNWSRCSKSCGSGVKVRSKWLREKPYNGGRP 1072
W S WS+C+ SCG GV+ RS + GGRP
Sbjct: 1123 AGPSRGSWFASPWSQCTASCGGGVQTRS----VQCLAGGRP 1159
Score = 53.1 bits (126), Expect = 2e-06
Identities = 57/218 (26%), Positives = 88/218 (40%), Gaps = 34/218 (15%)
Query: 31 PLPLLLLLLLRPGAGRAAAQGEAEAPTLYLWKTGPWGRCMGDECGPGGIQTRAVWCAHVE 90
P+P L P + R A ++ P W GPW C CG G + RAV C
Sbjct: 964 PVPASLCPQPAPSS-RQACNSQSCPPA---WSAGPWAEC-SHTCGKGW-RKRAVACKSTN 1017
Query: 91 GWTTLH----TNCKQAERPNNQQNCF-KVCDWHKELYDWRLGPWNQCQPVISKSLEKP-L 144
C +P + C + C K+L W + W+QC + +K L
Sbjct: 1018 PSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKL-QWLVSAWSQCSVTCERGTQKRFL 1076
Query: 145 ECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACL-IPCQQDCIVSEF--- 200
+C + + RE+A +K +P +P LE+AC +PC + +
Sbjct: 1077 KCAEKYVSGKYRELAS-KKCSHLP---------KPSLELERACAPLPCPRHPPFAAAGPS 1126
Query: 201 ------SAWSECSKTCGSGLQHRTRHVVAPPQFGGSGC 232
S WS+C+ +CG G+Q R+ +A + SGC
Sbjct: 1127 RGSWFASPWSQCTASCGGGVQTRSVQCLAGGR-PASGC 1163
Score = 50.8 bits (120), Expect = 1e-05
Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 7/92 (7%)
Query: 198 SEFSAWSECSKTCGSGLQHRTRHVVAP-PQFGGSGCPNLTE-FQVCQSSPCEAEELRYSL 255
S++S+WS CS+TCG G+ HR+R P P GG C T ++C S C + + +
Sbjct: 590 SDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRA 649
Query: 256 HVGPWSTCSMPHSRQVRQARRRGKNKEREKDR 287
+ C+ +SR+ R + K + +D+
Sbjct: 650 -----AQCAEHNSRRFRGRHYKWKPYTQVEDQ 676
Score = 45.4 bits (106), Expect = 4e-04
Identities = 72/306 (23%), Positives = 102/306 (33%), Gaps = 61/306 (19%)
Query: 1326 PSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDE 1385
P L + +P P +P Y W + S C V CG G T V +G D V+
Sbjct: 858 PRLGTEKQP-PAQPSYTWAIVR-SECSVS---CGGGQMT------VREGCYRDLKFQVNM 906
Query: 1386 EFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWS--SWSLCQLTCVNGEDLGFGGIQV 1443
FC + G PC WS +WS C TC G +Q
Sbjct: 907 SFCNPKTRPVTG----------LVPCKVSACPPSWSVGNWSACSRTCGGGAQSR--PVQC 954
Query: 1444 RSRPVIIQELENQHLCPEQMLETKSCYDGQCYEYKWMASAWKGSSRTV---WCQRSDGIN 1500
R E LCP+ ++ + Q W A W S T W +R+
Sbjct: 955 TRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACK 1014
Query: 1501 VTG-GCLVMSQPDADRSCNPP-----------CSQPH---------SYCSET-------K 1532
T PDA + P C +P S CS T +
Sbjct: 1015 STNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKR 1074
Query: 1533 TCHCEEGYTEVMSSNSTLEQCTLIPVVVLPTMEDKRGDVKTSRAVHPTQPSSNPAGRGRT 1592
C E Y ++C+ +P P++E +R HP ++ P+ RG +
Sbjct: 1075 FLKCAEKYVSGKYRELASKKCSHLP---KPSLELERACAPLPCPRHPPFAAAGPS-RG-S 1129
Query: 1593 WFLQPF 1598
WF P+
Sbjct: 1130 WFASPW 1135
Score = 44.3 bits (103), Expect = 0.001
Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 1031 PCPSDCKLSEWSNWSRCSKSCGSGVKVRSK-WLREKPYNGGRPC 1073
P P+ S+WS+WS CS++CG GV RS+ KP +GG+ C
Sbjct: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFC 625
Score = 42.0 bits (97), Expect = 0.005
Identities = 67/306 (21%), Positives = 94/306 (30%), Gaps = 62/306 (20%)
Query: 322 GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWS--EWSPCSKTCHDM 379
G T C ++SFC + P+T C S WS WS CS+TC
Sbjct: 888 GQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS-WSVGNWSACSRTCGGG 946
Query: 380 VSPAGTRVRTRTIRQFPIGSEKECPE--FEEKEPCLSQGDGVVPCATYGWRTTEWTECRV 437
+ R CP+ ++ C SQ W W EC
Sbjct: 947 AQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQS------CPPAWSAGPWAEC-- 998
Query: 438 DPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHK-NKEASKPMDLKLCTG 496
+ CG G + R V C N + +QL KP + C
Sbjct: 999 --------------SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC-- 1042
Query: 497 PIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVT 556
Q CH P + V SAW C+ C K+ K ++ ++ + +
Sbjct: 1043 ----LLQRCHKPKKLQWLV---SAWSQCSV-TCERGTQKRFLKCAEKYVSGKYR--ELAS 1092
Query: 557 GNCPHL----------LEAIPCEE--------PACYDWKAVRLGNCEPDNGKECGPGTQV 598
C HL +PC P+ W A C CG G Q
Sbjct: 1093 KKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCT----ASCGGGVQT 1148
Query: 599 QEVVCI 604
+ V C+
Sbjct: 1149 RSVQCL 1154
Score = 38.9 bits (89), Expect = 0.042
Identities = 28/83 (33%), Positives = 33/83 (39%), Gaps = 8/83 (9%)
Query: 1284 PVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQG-DGRPCPSLMDQSKPCPVKPCYR 1342
P + SDWS WS CS+TCG G R R T P G+ C K C + C R
Sbjct: 584 PTHGHWSDWSSWSPCSRTCG-GGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPR 642
Query: 1343 WQYGQWSPCQVQEAQCGEGTRTR 1365
+ AQC E R
Sbjct: 643 ------DSVDFRAAQCAEHNSRR 659
Score = 37.7 bits (86), Expect = 0.093
Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 15/97 (15%)
Query: 628 DAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGE--EGGIR--------- 676
+ P P S WS+WS CS TC G + ++ ++ G+ EG R
Sbjct: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
Query: 677 CPNSSALQEVRSCNEHPCTVY---HWQTGPWGQCIED 710
CP S C EH + H++ P+ Q +ED
Sbjct: 640 CPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQ-VED 675
Score = 33.1 bits (74), Expect = 2.3
Identities = 12/18 (66%), Positives = 14/18 (77%)
Query: 364 SEWSEWSPCSKTCHDMVS 381
S+WS WSPCS+TC VS
Sbjct: 590 SDWSSWSPCSRTCGGGVS 607
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,386,461
Number of Sequences: 37866
Number of extensions: 4353573
Number of successful extensions: 15183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 11168
Number of HSP's gapped (non-prelim): 1900
length of query: 1657
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1541
effective length of database: 13,855,062
effective search space: 21350650542
effective search space used: 21350650542
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.