Search of human proteins with 148664184

Search of human proteins with 148664184

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
         (541 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148664184 solute carrier family 22, member 10 [Homo sapiens]      1073   0.0  
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       666   0.0  
gi|153791484 putative UST1-like organic anion transporter [Homo ...   649   0.0  
gi|42542386 solute carrier family 22 (organic anion/cation trans...   632   0.0  
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          508   e-144
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          491   e-139
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   419   e-117
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   417   e-116
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       395   e-110
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          378   e-105
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   375   e-104
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   373   e-103
gi|166064021 solute carrier family 22 (organic anion transporter...   283   3e-76
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   265   6e-71
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          263   4e-70
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   260   2e-69
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          216   3e-56
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           207   2e-53
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           196   5e-50
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   194   1e-49
gi|169202895 PREDICTED: similar to solute carrier family 22, mem...   189   7e-48
gi|239750073 PREDICTED: similar to solute carrier family 22, mem...   189   7e-48
gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo ...   189   7e-48
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          173   4e-43
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        171   2e-42
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   159   5e-39
gi|157426885 organic cation transporter like 4 [Homo sapiens]         157   3e-38
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       152   6e-37
gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   130   3e-30
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   111   1e-24

>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 1073 bits (2776), Expect = 0.0
 Identities = 541/541 (100%), Positives = 541/541 (100%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
           GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL
Sbjct: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA
Sbjct: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
           LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR
Sbjct: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN
Sbjct: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI
Sbjct: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA
Sbjct: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 540
           ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK
Sbjct: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 540

Query: 541 A 541
           A
Sbjct: 541 A 541


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  666 bits (1718), Expect = 0.0
 Identities = 326/542 (60%), Positives = 417/542 (76%), Gaps = 2/542 (0%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M F+ LL QVGG+GRFQ+  + F   + +LL P+I+LENF A  P HRCWV +LDN+T S
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+TG LS+D LLRISIPLDSNLRP+KC+RF+HPQWQLLHLNGT  +T+E DTEPCVDGW
Sbjct: 61  DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW 120

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VYD+S F STIVT+WDLVC+ QSLKS+VQ L + G L+GG+I GH+SDR GR+ I + C 
Sbjct: 121 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF 180

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQLAI++TCAAFAPTF VYC+LRFLAGFS+M I+ N  +   EW  P S+++ +++   +
Sbjct: 181 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS 240

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S+GQ++LGGLA+  +DW  L +  S P  V FL S  +VESARWLII N+LDEGLK LR
Sbjct: 241 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR 300

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VA  NG KN EETL  E+VRSTM++ELDA + KT++  LFR P +R R+  L F+RFA 
Sbjct: 301 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAI 360

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           T+PFYG ++NLQH+GSN+ L Q+L GAV    RC++LLTLNHMGRRISQILF F VGL I
Sbjct: 361 TVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           L NTF+P+EMQ LRV LA LGIG  +A  +S +VH  EL+PT+LR+  +GI+  + R GA
Sbjct: 421 LVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGA 480

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQK--KNLK 538
           ALAPLLMTL  +   LPWI YG+FPI+   ++ LLPET++LPLP+TI+DVEN+K  +N+K
Sbjct: 481 ALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENEKDSRNIK 540

Query: 539 EK 540
           ++
Sbjct: 541 QE 542


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  649 bits (1675), Expect = 0.0
 Identities = 323/536 (60%), Positives = 404/536 (75%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF++LL QVGGLGRFQ+L +VF++   +++     LENFAA I  HRCWVH+LDN+T  
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+ G LS+DALLRISIP DSNLRPEKCRRFVHPQW+L+HLNGT  +TSE DTEPCVDGW
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGW 120

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VYDQS FPSTIVTKWDLVC+ Q L SV +FL + GM+VGG + GH+SDRFGR+F+LRW  
Sbjct: 121 VYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSY 180

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQLAI  TCAAFAPT  VYC LRFLAG ++  II N  L I EWI     A+ + L+  A
Sbjct: 181 LQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCA 240

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            SIG I LG LA+V RD   L +V S P FVFFL SRWL ESARWLII NK +EGLK LR
Sbjct: 241 ASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELR 300

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           K A  NG+KNAE+ L +EV++STM++EL+AAQ K ++C+L R P++ KRIC L F+RFA+
Sbjct: 301 KAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFAS 360

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           TIPF+G  ++LQH+G+N+FLLQ L+GAV L+  C+A   LNHM RR+SQ+L MFL+   +
Sbjct: 361 TIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCL 420

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           LA  FVP+EMQTLRV LA LG+G ++   +       ELIP+++R RA+GI    + IG 
Sbjct: 421 LAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGG 480

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKN 536
           ALA L+M L+++   LPWIIYG+F I+ GL+V LLPET+N PL D+I+DVEN+  N
Sbjct: 481 ALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVN 536


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  632 bits (1631), Expect = 0.0
 Identities = 308/540 (57%), Positives = 400/540 (74%), Gaps = 1/540 (0%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF++LL   G L RFQ+L  VF+    +    H +LENF A IPGHRCWVH+LDN+T S
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+TG LS+DALLRISIPLDSN+RPEKCRRFVHPQWQLLHLNGT  +TS+AD EPCVDGW
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGW 120

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VYD+  F STIVT+WDLVCD QSL SV +F+ + GM+VGGI+GGH+SDRFGRRF+LRWC 
Sbjct: 121 VYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCY 180

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ+AI  TCAA APTF +YC LRFL+G ++M +I+N  + I EW     +A+ + L    
Sbjct: 181 LQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCP 240

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
             I  + L GLA+  RDW  L +V SVP+FV FL S WL+ESARWLII NK +EGLK LR
Sbjct: 241 SGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELR 300

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQ-TKTTVCDLFRNPSMRKRICILVFLRFA 359
           K A  +G+KNA +TL +E+++STM++EL+AAQ  K ++C++   P++ KRI +L F RFA
Sbjct: 301 KAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFA 360

Query: 360 NTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLS 419
           N + ++G  +++QH+G+N+FLLQ L+GAV L+  C+A   L +M RR SQ+L MFL+ + 
Sbjct: 361 NFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAIC 420

Query: 420 ILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479
           +LA  FVP+EMQTLR  LA LG+G SA   +    H  E+IPT++RARA GI+ T + I 
Sbjct: 421 LLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIA 480

Query: 480 AALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKE 539
            ALAPL+M L+V+   LPWIIYG+FP I G    LLPET+N PL DTI+D +N++K+ +E
Sbjct: 481 GALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPRE 540


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  508 bits (1309), Expect = e-144
 Identities = 268/533 (50%), Positives = 341/533 (63%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF ELL  VGGLGRFQ+L  + ++ S+M L    +LENF+AA+P HRCW  +LDN+T  
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            +  G LS +ALL ISIP   N RP +CRRF  PQWQLL  N T  S SEADTEPCVDGW
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW 120

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VYD+S F STIV KW+LVCD  +LK + Q + L G+LVG    G  SDRFGRR +L W  
Sbjct: 121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY 180

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ+A+  T AAFAP FPVYC+ RFL  F+   ++ N    + EW    ++ LV+ L+S  
Sbjct: 181 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG 240

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S G  +   +AY  RDW  L +V SVPFF+ FL S WL ESARWL+ T +LD GL+ L 
Sbjct: 241 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW 300

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VA  NG    ++TL  EV+ S M+EEL   Q   ++  L R P +R R CI     FA 
Sbjct: 301 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF 360

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
              F+G  ++LQ +GSNIFLLQ+  G V +  +  ALL L+H+GRR +    + L GL I
Sbjct: 361 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI 420

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           LANT VP EM  LR ALA LG+G   A F+ + ++  EL PTVLR  A G+   A+R GA
Sbjct: 421 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA 480

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
            L PL+  L V    LP ++YG  P++ GL   LLPET++LPLPDTI+DV+NQ
Sbjct: 481 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQ 533


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  491 bits (1263), Expect = e-139
 Identities = 268/536 (50%), Positives = 348/536 (64%), Gaps = 7/536 (1%)

Query: 1   MAFEELLSQVGGLGRFQMLH-LVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTG 59
           MAF +LL Q GG+G FQ L  L FILP LM+    +LLENF+AAIPGHRCW HMLDN  G
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIP-SQMLLENFSAAIPGHRCWTHMLDN--G 57

Query: 60  SGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDG 119
           S   T  ++  ALL ISIP   N  P +CRRF  PQWQLL  N T  S SEADTEPCVDG
Sbjct: 58  SAVSTN-MTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDG 116

Query: 120 WVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWC 179
           WVYD+S F STIV KWDLVC  Q LK + Q + ++G+LVG  I G +S RFGR+ +L WC
Sbjct: 117 WVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWC 176

Query: 180 LLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSG 239
            LQLA+  T   FAPTF +YC LRF+A F    I  ++   + EW   + +A+ + +   
Sbjct: 177 CLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGC 236

Query: 240 ALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKAL 299
           A S GQ  LGGLA+  RDW+TL + ASVPFF   L+S WL ESARWLII  K D+ L+ L
Sbjct: 237 AFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQEL 296

Query: 300 RKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFA 359
           RKVAR NG K A + L IEV+ S+++EE+ +A+   +V DLF  P +R R C ++ + F+
Sbjct: 297 RKVARINGHKEA-KNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFS 355

Query: 360 NTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLS 419
             I +YG + +LQ +G +IFLLQ L+GAV  + R    L L+ +GRR  Q     + GL+
Sbjct: 356 LLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLA 415

Query: 420 ILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIG 479
           ILAN  VP+++QTLRV  A LG GC   + + + ++  EL PT +R  A GI  T  R+G
Sbjct: 416 ILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLG 475

Query: 480 AALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIV-FLLPETKNLPLPDTIKDVENQK 534
           A + PL++        LP ++YG+  I   L+V F LPET+ LPLPDTI+D+E+QK
Sbjct: 476 AMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQK 531


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  419 bits (1076), Expect = e-117
 Identities = 213/534 (39%), Positives = 328/534 (61%), Gaps = 11/534 (2%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF +LL QVGG+GRFQ + +  ++  L+L+  H  L+NF AAIP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  +     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT-EANGTGATEPCTDGW 109

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           +YD S FPSTIVT+WDLVC +++L+ + Q L + G+L+G ++ G+++DR GRR +L    
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ A++ TCAAFAP FP+YC  R L+G +   I  N      EW+  +++A V  L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S+GQ +L G+AY    W+ L ++ S PFF FF+ S + +ESARW   + +LD  L+AL+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VAR NG +     L++EV+R+++Q+EL   + + +  +L R P++R     L  L FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           +  +YG +++LQ  G +I+L+QV++GAV L  + +  L +N +GRR +Q+  + L G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           L N  +P++   +R +LA LG GC AA+F+ + ++  EL PT++R    G+  T +R+G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQK 534
            ++PL+      + ++P  IYG  P+    +  LLPET   PLPDT++D+E++K
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRK 523


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  417 bits (1071), Expect = e-116
 Identities = 212/533 (39%), Positives = 327/533 (61%), Gaps = 11/533 (2%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF +LL QVGG+GRFQ + +  ++  L+L+  H  L+NF AAIP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  +     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT-EANGTGATEPCTDGW 109

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           +YD S FPSTIVT+WDLVC +++L+ + Q L + G+L+G ++ G+++DR GRR +L    
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ A++ TCAAFAP FP+YC  R L+G +   I  N      EW+  +++A V  L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S+GQ +L G+AY    W+ L ++ S PFF FF+ S + +ESARW   + +LD  L+AL+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VAR NG +     L++EV+R+++Q+EL   + + +  +L R P++R     L  L FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           +  +YG +++LQ  G +I+L+QV++GAV L  + +  L +N +GRR +Q+  + L G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           L N  +P++   +R +LA LG GC AA+F+ + ++  EL PT++R    G+  T +R+G+
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
            ++PL+      + ++P  IYG  P+    +  LLPET   PLPDT++D+E++
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESR 522


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  395 bits (1014), Expect = e-110
 Identities = 219/549 (39%), Positives = 318/549 (57%), Gaps = 19/549 (3%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF +LL  +G +GRFQ+ H   +L    LL  H  L+NF AA+P H C         G 
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHC--------RGP 52

Query: 61  GNETGILSED--ALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVD 118
            N T   + D  A LR +IPLD    PE CRRF  PQW LL  N +I     A TE C D
Sbjct: 53  ANHTEASTNDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPG---AATEGCKD 109

Query: 119 GWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRW 178
           GWVY++S FPSTIV +WDLVC+ ++L+ + Q + + G+LVG  + G ++DR G +  L W
Sbjct: 110 GWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVW 169

Query: 179 CLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSS 238
             LQLA +    A+  +F  YCV RFL G +   II N+   + EW+    + +  IL  
Sbjct: 170 SYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLG 229

Query: 239 GALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKA 298
            + ++GQ+IL G+AY+ R W+ L    S PF +FFL S WL ES+RWL++  K    ++ 
Sbjct: 230 YSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQN 289

Query: 299 LRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRF 358
           L+KVA  NG K   E L  EV+ S +Q E  +  T  ++ DLFR P++RK  C L+ + F
Sbjct: 290 LQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWF 349

Query: 359 ANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGL 418
           +N++ +YG  ++LQ  G +++L+Q L+G +      +A  T+ ++GRR +   F+ L GL
Sbjct: 350 SNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGL 409

Query: 419 SILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRI 478
            ++AN FVP+  Q L  A A LG GC A++F  V +   EL PT +R    G     +R+
Sbjct: 410 MVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARL 469

Query: 479 GAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE------N 532
           G   APL+ TL  + T LP + +G   I+ GL V +L ET+N+PL +TI  +E      +
Sbjct: 470 GGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGS 529

Query: 533 QKKNLKEKA 541
            KK+++EK+
Sbjct: 530 SKKHVEEKS 538


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  378 bits (971), Expect = e-105
 Identities = 203/539 (37%), Positives = 311/539 (57%), Gaps = 23/539 (4%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M F E+L +VG +G FQ LH+  +   ++ +  H LL+ F AA P H C      +N  +
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC---RPPHNAST 57

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
           G               +P+  N +PE+C RFVHP       N ++ + ++   EPC+DGW
Sbjct: 58  GPWV------------LPMGPNGKPERCLRFVHPP------NASLPNDTQRAMEPCLDGW 99

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           VY+ +    +IVT+WDLVC+   LK + Q + + G+L+GG++ G +SDRFGRR IL    
Sbjct: 100 VYNST--KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSY 157

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           L LA + + AAF+PTFP+Y V RFL GF    I  +  +   EW+    +A++       
Sbjct: 158 LLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYC 217

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            + GQ IL GLAY    W+ L +  S+PFFVFFL S W  ES RWL+++ K  + LK LR
Sbjct: 218 YTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILR 277

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VA  NG K   E L++E ++  +Q+E+  A+ K T  DLFR P +R+    L    FA 
Sbjct: 278 RVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFAT 337

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
              +Y   + ++  G N+++LQ+++G V +  + + +L+L+++GR  +Q   + L G +I
Sbjct: 338 GFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAI 397

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           LA TFVP ++QT+R  LA  G GC +++FS + ++  EL PTV+R    G+    +R+G+
Sbjct: 398 LALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGS 457

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKE 539
            ++PL+         +P IIYGI  ++GG     LPET N PLP+TI+D+EN     K+
Sbjct: 458 MVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKK 516


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  375 bits (963), Expect = e-104
 Identities = 203/534 (38%), Positives = 307/534 (57%), Gaps = 55/534 (10%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF +LL QVGG+GRFQ + +  ++  L+L+  H  L+NF AAIP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  +     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT-EANGTGATEPCTDGW 109

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           +YD S FPSTIVT+WDLVC +++L+ + Q L + G+L+G ++ G+++DR GRR +L    
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ A++ TCAAFAP FP+YC  R L+G +   I  N      EW+  +++A V  L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S+GQ +L G+AY    W+ L ++ S PFF FF+ S + +ESARW   + +LD  L+AL+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VAR NG +     L++EV+R+++Q+EL   + + +  +L R P++R     L  L FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           +  +YG +++LQ  G +I+L+QV++GAV L  + +  L +N +GRR +Q+  + L G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           L N  +P++   +R +LA LG GC AA+F+ + ++  EL PT++RA              
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQK 534
                                         +  LLPET   PLPDT++D+E++K
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLESRK 479


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  373 bits (958), Expect = e-103
 Identities = 202/533 (37%), Positives = 306/533 (57%), Gaps = 55/533 (10%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           MAF +LL QVGG+GRFQ + +  ++  L+L+  H  L+NF AAIP H C      N    
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADAN---- 56

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
                 LS++  L + +P D   +PE C RF  PQW L  LNGT  +     TEPC DGW
Sbjct: 57  ------LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT-EANGTGATEPCTDGW 109

Query: 121 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL 180
           +YD S FPSTIVT+WDLVC +++L+ + Q L + G+L+G ++ G+++DR GRR +L    
Sbjct: 110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 181 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA 240
           LQ A++ TCAAFAP FP+YC  R L+G +   I  N      EW+  +++A V  L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 241 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR 300
            S+GQ +L G+AY    W+ L ++ S PFF FF+ S + +ESARW   + +LD  L+AL+
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 301 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN 360
           +VAR NG +     L++EV+R+++Q+EL   + + +  +L R P++R     L  L FA 
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI 420
           +  +YG +++LQ  G +I+L+QV++GAV L  + +  L +N +GRR +Q+  + L G+ I
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 421 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA 480
           L N  +P++   +R +LA LG GC AA+F+ + ++  EL PT++RA              
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRA-------------- 455

Query: 481 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
                                         +  LLPET   PLPDT++D+E++
Sbjct: 456 ------------------------------VTVLLPETLGQPLPDTVQDLESR 478


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  283 bits (724), Expect = 3e-76
 Identities = 173/530 (32%), Positives = 278/530 (52%), Gaps = 19/530 (3%)

Query: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLEN-FAAAIPGHRCWVHMLDNNTGSG 61
           F ++L+++G  GRFQ + L+ +L  L  L P     + F      H C V  + N+T + 
Sbjct: 4   FVQVLAEIGDFGRFQ-IQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFN- 61

Query: 62  NETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGWV 121
                LS    L +S+PLD+   PE C  F  P       +   H  +E  T+PC  GW 
Sbjct: 62  -----LSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNE--TQPCDMGWE 114

Query: 122 YDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLL 181
           Y ++  PS +  +++LVCD + LK   Q + + G+LVG ++ G + DR GR+  +   LL
Sbjct: 115 YPENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173

Query: 182 QLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGAL 241
              +     AF P+F +Y  LRF    +   +  +N   +TEW+ P+ +   V+L+    
Sbjct: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233

Query: 242 SIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRK 301
           S+GQ++L GLAY FR+W+ L +  + P  + F     L ESARWL+   ++DE ++ ++K
Sbjct: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293

Query: 302 VARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANT 361
            A  N  K + E +N  V   T               DLFR+P +RK   I+  + F ++
Sbjct: 294 AASVNRRKLSPELMNQLVPEKT--------GPSGNALDLFRHPQLRKVTLIIFCVWFVDS 345

Query: 362 IPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSIL 421
           + +YG  + +   G +++L Q+++GAV +  RC ++  +   GR+ SQ+  + L GL  +
Sbjct: 346 LGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCI 405

Query: 422 ANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAA 481
              F+P ++  +   LA +G   +AA F+   V+  EL PT+LR    G+    SRIG  
Sbjct: 406 IIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGI 465

Query: 482 LAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531
           L PL++ L  +   LP +IYG  PI+ GL+  LLPET    L DT++D+E
Sbjct: 466 LTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLE 515


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  265 bits (678), Expect = 6e-71
 Identities = 169/539 (31%), Positives = 264/539 (48%), Gaps = 17/539 (3%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M FEELL QVGG G FQ+ ++  +    +LL  H LL  F AA+P HRC +         
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCAL--------P 52

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHST-----SEADTEP 115
           G       +D  L   +P + +     C RF +PQ       G    +      E  T P
Sbjct: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVP 112

Query: 116 CVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFI 175
           C  GW YD S F STI T+WDLVC+ + L          G+LVG +  G++SDRFGRR +
Sbjct: 113 CSQGWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRL 172

Query: 176 LRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPIT-EWIRPNSKALVV 234
           L    +   +    +A + ++ ++ + R L G S++   +   +P+  EW+    + +  
Sbjct: 173 LLVAYVSTLVLGLASAASVSYVMFAITRTLTG-SALAGFTIIVMPLELEWLDVEHRTVAG 231

Query: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294
           +LSS   + G ++L  + Y+ RDW+ L +  ++P     L   W+ ESARWL+    + E
Sbjct: 232 VLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKE 291

Query: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILV 354
             + L   AR NG    E++ + E V      E      + +  DLFR P +R      V
Sbjct: 292 AHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCV 349

Query: 355 FLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMF 414
            + F     +YG  +++  +G N++  Q+L+GAV L  + L  L++ + GRR++Q   + 
Sbjct: 350 VVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL 409

Query: 415 LVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLT 474
              L+      V  +M++    LA +G   S A F++  +   EL PTVLR    G+   
Sbjct: 410 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 469

Query: 475 ASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533
             R+G +LAPL   L   + +LP + YG   ++      LLPET+   LP+TI+DVE +
Sbjct: 470 VGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK 528


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  263 bits (671), Expect = 4e-70
 Identities = 145/311 (46%), Positives = 191/311 (61%)

Query: 223 EWIRPNSKALVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVES 282
           EW    ++ LV+ L+S   S G  +   +AY  RDW  L +V SVPFF+ FL S WL ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 283 ARWLIITNKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFR 342
           ARWL+ T +LD GL+ L +VA  NG    ++TL  EV+ S M+EEL   Q   ++  L R
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLR 121

Query: 343 NPSMRKRICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNH 402
            P +R R CI     FA    F+G  ++LQ +GSNIFLLQ+  G V +  +  ALL L+H
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH 181

Query: 403 MGRRISQILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPT 462
           +GRR +    + L GL ILANT VP EM  LR ALA LG+G   A F+ + ++  EL PT
Sbjct: 182 LGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 241

Query: 463 VLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLP 522
           VLR  A G+   A+R GA L PL+  L V    LP ++YG  P++ GL   LLPET++LP
Sbjct: 242 VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLP 301

Query: 523 LPDTIKDVENQ 533
           LPDTI+DV+NQ
Sbjct: 302 LPDTIQDVQNQ 312


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  260 bits (665), Expect = 2e-69
 Identities = 169/541 (31%), Positives = 264/541 (48%), Gaps = 19/541 (3%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M FEELL QVGG G FQ+ ++  +    +LL  H LL  F AA+P HRC +         
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCAL--------P 52

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHST-----SEADTEP 115
           G       +D  L   +P + +     C RF +PQ       G    +      E  T P
Sbjct: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVP 112

Query: 116 CVDGWVYDQSYFPSTIVTK--WDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRR 173
           C  GW YD S F STI T+  WDLVC+ + L          G+LVG +  G++SDRFGRR
Sbjct: 113 CSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 172

Query: 174 FILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPIT-EWIRPNSKAL 232
            +L    +   +    +A + ++ ++ + R L G S++   +   +P+  EW+    + +
Sbjct: 173 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTG-SALAGFTIIVMPLELEWLDVEHRTV 231

Query: 233 VVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKL 292
             +LSS   + G ++L  + Y+ RDW+ L +  ++P     L   W+ ESARWL+    +
Sbjct: 232 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 291

Query: 293 DEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICI 352
            E  + L   AR NG    E++ + E V      E      + +  DLFR P +R     
Sbjct: 292 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLC 349

Query: 353 LVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILF 412
            V + F     +YG  +++  +G N++  Q+L+GAV L  + L  L++ + GRR++Q   
Sbjct: 350 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 409

Query: 413 MFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGID 472
           +    L+      V  +M++    LA +G   S A F++  +   EL PTVLR    G+ 
Sbjct: 410 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469

Query: 473 LTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVEN 532
               R+G +LAPL   L   + +LP + YG   ++      LLPET+   LP+TI+DVE 
Sbjct: 470 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 529

Query: 533 Q 533
           +
Sbjct: 530 K 530


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  216 bits (551), Expect = 3e-56
 Identities = 144/419 (34%), Positives = 213/419 (50%), Gaps = 13/419 (3%)

Query: 115 PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRF 174
           PC  GW Y Q++  STIV+++DLVC    +  + Q +L  G L G    G+ +DR+GR  
Sbjct: 126 PCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIV 183

Query: 175 ILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVV 234
           I     L + +T    AFAP FPV+ + RFL G           + +TE +    + +V 
Sbjct: 184 IYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVG 243

Query: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLV-ESARWLIITNKLD 293
           I+     ++G IIL G+AY   +WQ + +  ++P F+F LL  W+V ES RWLI   K D
Sbjct: 244 IVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLF-LLYYWVVPESPRWLITRKKGD 302

Query: 294 EGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICIL 353
           + L+ LR++A+ NG   +     I V         D   +  +  DL R P MRK   IL
Sbjct: 303 KALQILRRIAKCNGKYLSSNYSEITVT--------DEEVSNPSFLDLVRTPQMRKCTLIL 354

Query: 354 VFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFM 413
           +F  F + + + G ++ L  +G N+++   + G V L    L LLT+  +GRR+      
Sbjct: 355 MFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASN 414

Query: 414 FLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDL 473
            + G++ L   F+P+ +  LR  +A LG       F  V +   EL PT LR     +  
Sbjct: 415 IVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCS 474

Query: 474 TASRIGAALAP-LLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531
                G  +AP LL  L   +  LP II+GI   I G +V LLPETK + LP+T+ DVE
Sbjct: 475 GLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  207 bits (527), Expect = 2e-53
 Identities = 137/465 (29%), Positives = 233/465 (50%), Gaps = 20/465 (4%)

Query: 85  PEKCRRFVHPQWQLLHLNGTIHSTSEADTE-------PCVDGWVYDQSYFPSTIVTKWDL 137
           P +CRR+    W     +  +   +  DT        PC DGWVY+     S+IVT+++L
Sbjct: 86  PRQCRRY-EVDWNQSTFD-CVDPLASLDTNRSRLPLGPCRDGWVYETP--GSSIVTEFNL 141

Query: 138 VCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP 197
           VC    +  + Q  +  G  +G +  G+++DRFGR+  L   +L  A      A +PT+ 
Sbjct: 142 VCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT 201

Query: 198 VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRD 257
              + R + G  S        + ITE++    +  V I    A ++G ++L G+AY    
Sbjct: 202 WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPH 261

Query: 258 WQTLHVVASVPFFVFFLLSRWLV-ESARWLIITNKLDEGLKALRKVARTNGIKNAEETLN 316
           W+ L    ++P F FFLL  W + ES RWLI  NK  E ++ ++ +A+ NG     ++L 
Sbjct: 262 WRWLQFTVALPNF-FFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNG-----KSLP 315

Query: 317 IEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGS 376
             + R  ++EE    +   +  DL R P +RK   IL++  F +++ + G ++++   G 
Sbjct: 316 ASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGD 374

Query: 377 NIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQTLRVA 436
           NI+L       V      + +LT++ +GRR        + G + LA+ F+P ++Q L++ 
Sbjct: 375 NIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKII 434

Query: 437 LACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLM-TLTVFFTT 495
           ++CLG       +  V +   EL PT +R     I  +   IG  + P L+  LT  +  
Sbjct: 435 ISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLE 494

Query: 496 LPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 540
           LP +++G+  ++ G +V LLPETK   LP+TI++ EN ++  K K
Sbjct: 495 LPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNK 539


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  196 bits (498), Expect = 5e-50
 Identities = 156/538 (28%), Positives = 245/538 (45%), Gaps = 33/538 (6%)

Query: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHI--LLENFAAAIPGHRCWVHMLDNNTGS 60
           ++E+ + +G  G FQ   L+F L S  ++      L   F  A P HRC V    N + +
Sbjct: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSA 61

Query: 61  GNETGILSEDALLRISIPL---DSNLRPEKCRRF---VHPQWQLLHLN-GTIHSTSEADT 113
                          ++PL   D    P  CRR+       +  L L  G      + + 
Sbjct: 62  WRNH-----------TVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQ 110

Query: 114 EPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRR 173
           E C+DGW + Q  + STIVT+W+LVC+      +   L   G+L+G  I G +SDRFGR+
Sbjct: 111 ESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRK 170

Query: 174 FILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALV 233
            +L   +           F+  F ++ VL  L G      ISN             K++ 
Sbjct: 171 NVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQ---ISNYVAAFVLGTEILGKSVR 227

Query: 234 VILSSGALSI----GQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIIT 289
           +I S+  + I    G ++L   AY  RDW+ L V  ++P  +   L  ++ ES RWLI  
Sbjct: 228 IIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQ 287

Query: 290 NKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKR 349
            + +E    +RK A+ NGI       +     S +Q+     Q    + DL R  ++R  
Sbjct: 288 GRFEEAEVIIRKAAKANGIVVPSTIFD----PSELQDLSSKKQQSHNILDLLRTWNIRMV 343

Query: 350 ICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQ 409
             + + L    ++ ++G  ++  ++  +IF+   L   V +    LA L L ++ RR S 
Sbjct: 344 TIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSM 403

Query: 410 ILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARAS 469
              +FL G  +L    VP ++  L   L  +G     A FS V V+  EL PTV+R    
Sbjct: 404 ATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGV 463

Query: 470 GIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTI 527
           G+  TASR+G+ L+P  + L  +   LP+I+ G   I+  ++   LPE+   PLPDTI
Sbjct: 464 GVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  194 bits (494), Expect = 1e-49
 Identities = 128/428 (29%), Positives = 212/428 (49%), Gaps = 11/428 (2%)

Query: 115 PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRF 174
           PC DGWVYD     S+IVT+++LVC       + Q  L  G L G +  G+ +DRFGR+ 
Sbjct: 120 PCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL 177

Query: 175 ILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVV 234
            L   +L  A++    AF+P +    + R L G  S          ITE++   S+  V 
Sbjct: 178 CLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA 237

Query: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294
           I+   A ++G + L GLAY    W+ L +  S+P F+F L    + ES RWL+   +  E
Sbjct: 238 IMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTE 297

Query: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILV 354
            +K +  +A+ NG K     L +  +   + E+L       +  DLFR P +RKR  IL+
Sbjct: 298 AIKIMDHIAQKNG-KLPPADLKMLSLEEDVTEKL-----SPSFADLFRTPRLRKRTFILM 351

Query: 355 FLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRC-LALLTLNHMGRRISQILFM 413
           +L F +++ + G ++++     N++ L  LY A+  I    +AL+T++ +GR     +  
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLY-LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410

Query: 414 FLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDL 473
            L G + L   F+  ++  L + + C+G          + +   EL PT +R     +  
Sbjct: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCS 470

Query: 474 TASRIGAALAP-LLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVEN 532
           +   IG  + P ++  L   +  LP I++ +  ++   +  LLPETK + LP+T+KD EN
Sbjct: 471 SLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAEN 530

Query: 533 QKKNLKEK 540
             +  K K
Sbjct: 531 LGRKAKPK 538


>gi|169202895 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  189 bits (479), Expect = 7e-48
 Identities = 90/133 (67%), Positives = 105/133 (78%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M F+ LL QVGGLGRFQ+ HL+F+  S+++  PH+LLENF A IPGH  WVH+LDN+T S
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+TG LS+ ALLRISIPLDSNLRPEKCR F+HPQW LLHLN T  + SE +TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDQSYFPSTIVT 133
           VY QS F  TIVT
Sbjct: 121 VYHQSSFLFTIVT 133


>gi|239750073 PREDICTED: similar to solute carrier family 22, member
           24 [Homo sapiens]
          Length = 139

 Score =  189 bits (479), Expect = 7e-48
 Identities = 90/133 (67%), Positives = 105/133 (78%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M F+ LL QVGGLGRFQ+ HL+F+  S+++  PH+LLENF A IPGH  WVH+LDN+T S
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+TG LS+ ALLRISIPLDSNLRPEKCR F+HPQW LLHLN T  + SE +TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDQSYFPSTIVT 133
           VY QS F  TIVT
Sbjct: 121 VYHQSSFLFTIVT 133


>gi|239744382 PREDICTED: hypothetical protein XP_002343132 [Homo
           sapiens]
          Length = 139

 Score =  189 bits (479), Expect = 7e-48
 Identities = 90/133 (67%), Positives = 105/133 (78%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60
           M F+ LL QVGGLGRFQ+ HL+F+  S+++  PH+LLENF A IPGH  WVH+LDN+T S
Sbjct: 1   MGFDMLLDQVGGLGRFQIFHLIFLTISIIIHYPHLLLENFIAFIPGHHYWVHILDNDTVS 60

Query: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW 120
            N+TG LS+ ALLRISIPLDSNLRPEKCR F+HPQW LLHLN T  + SE +TEPCV GW
Sbjct: 61  DNDTGTLSQVALLRISIPLDSNLRPEKCRCFIHPQWHLLHLNVTFSNMSEPNTEPCVGGW 120

Query: 121 VYDQSYFPSTIVT 133
           VY QS F  TIVT
Sbjct: 121 VYHQSSFLFTIVT 133


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  173 bits (438), Expect = 4e-43
 Identities = 137/543 (25%), Positives = 245/543 (45%), Gaps = 31/543 (5%)

Query: 3   FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGN 62
           ++E+++ +G  G FQ L    +  S++    + +   F A  P HRC V    N + +  
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWR 63

Query: 63  ETGILSEDALLRISIPL---DSNLRPEKCRRF---VHPQWQLLHLN-GTIHSTSEADTEP 115
                        S+PL   D    P  C R+       +  L L  G      + + E 
Sbjct: 64  NN-----------SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES 112

Query: 116 CVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFI 175
           C+DGW + Q  + ST+VT+W+LVC+      +   L   G+L+G  + G +SDRFGR+ +
Sbjct: 113 CLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNV 172

Query: 176 LRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVI 235
           L   +           F+ ++ ++ VL  + G      ISN  +          K++ +I
Sbjct: 173 LFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQ---ISNYVVAFILGTEILGKSVRII 229

Query: 236 LSSGAL----SIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNK 291
            S+  +    ++G ++L   AY  RDW+ L +  +VP  +   L  ++ ES RWLI   +
Sbjct: 230 FSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRR 289

Query: 292 LDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRIC 351
             E    ++K A+ N I          V+  +++E     Q K  + DLFR  ++     
Sbjct: 290 FREAEDIIQKAAKMNNIAVPA------VIFDSVEELNPLKQQKAFILDLFRTRNIAIMTI 343

Query: 352 ILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQIL 411
           + + L    ++ ++   ++  ++  + +L   L   + +     A L L  + RR     
Sbjct: 344 MSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAA 403

Query: 412 FMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGI 471
            +F  G  +L    VP +   L + L  LG     + FS + V   EL PT++R  A G+
Sbjct: 404 VLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463

Query: 472 DLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVE 531
             TASR+G+ +AP  + L  +   LP+I+ G   ++ G++    PE+  + LP+T++ ++
Sbjct: 464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523

Query: 532 NQK 534
             K
Sbjct: 524 KVK 526


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  171 bits (432), Expect = 2e-42
 Identities = 141/555 (25%), Positives = 252/555 (45%), Gaps = 27/555 (4%)

Query: 3   FEELLSQVGGLGRFQ-MLHLVFILPSLMLLIPHILLENFAAAIPGHRC-------WVHML 54
           FE +   VG  GRFQ +L+ +    ++   I H L   F    P H C        V   
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGI-HYLASVFMGVTPHHVCRPPGNVSQVVFH 64

Query: 55  DNNTGSGNETG-ILSEDALLRISIPLDSNLRPE--KCRRFVHPQWQLLHLNGTIHSTSEA 111
           +++  S  +TG +LS      +++ L +    E  +C R        L   G  ++ S+ 
Sbjct: 65  NHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSL---GYEYTGSKK 121

Query: 112 DTEPCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFG 171
           +  PCVDG++YDQ+ + ST VT+W+LVCD + L  ++Q L + G+L+G +  G+ SDR G
Sbjct: 122 EF-PCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180

Query: 172 RRFILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKA 231
           RR +L      + +    AAFA  +  +   RF     +   +    + + E+I   S+ 
Sbjct: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240

Query: 232 LVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNK 291
              +      ++G +++    Y+ R W    ++ S     F L    L E+  WL+   +
Sbjct: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300

Query: 292 LDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQT---KTTVCDLFRNPSMRK 348
            +E  K +  +A+ N   + + +   E++   +Q  +  + T   K  +  LF N S+ K
Sbjct: 301 YEEAQKIVDIMAKWNRASSCKLS---ELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITK 357

Query: 349 RICILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRIS 408
           R   +  + F  ++ FY   +N  ++G N +L   L G V +       + ++ +GRR  
Sbjct: 358 RTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTV 417

Query: 409 QILFMFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARA 468
               +F   L+      +P++   L V  A +G     A F  + ++  EL PT++R+ A
Sbjct: 418 LAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLA 477

Query: 469 SGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIK 528
            G      R+ + LAP  + L+  +  +P +  G   ++ G++   LPET    L  T +
Sbjct: 478 VGSGSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWE 537

Query: 529 DV-----ENQKKNLK 538
           +      EN+ K+ K
Sbjct: 538 EAAKLESENESKSSK 552


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  159 bits (403), Expect = 5e-39
 Identities = 110/367 (29%), Positives = 179/367 (48%), Gaps = 13/367 (3%)

Query: 115 PCVDGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRF 174
           PC DGWVYD     S+IVT+++LVC       + Q  L  G L G +  G+ +DRFGR+ 
Sbjct: 120 PCQDGWVYDTP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL 177

Query: 175 ILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVV 234
            L   +L  A++    AF+P +    + R L G  S          ITE++   S+  V 
Sbjct: 178 CLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVA 237

Query: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294
           I+   A ++G + L GLAY    W+ L +  S+P F+F L    + ES RWL+   +  E
Sbjct: 238 IMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTE 297

Query: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILV 354
            +K +  +A+ NG K     L +  +   + E+L       +  DLFR P +RKR  IL+
Sbjct: 298 AIKIMDHIAQKNG-KLPPADLKMLSLEEDVTEKL-----SPSFADLFRTPRLRKRTFILM 351

Query: 355 FLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRC-LALLTLNHMGRRISQILFM 413
           +L F +++ + G ++++     N++ L  LY A+  I    +AL+T++ +GR     +  
Sbjct: 352 YLWFTDSVLYQGLILHMGATSGNLY-LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSN 410

Query: 414 FLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRA---RASG 470
            L G + L   F+  ++  L + + C+G          + +   EL PT +        G
Sbjct: 411 LLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVGPACRG 470

Query: 471 IDLTASR 477
            D T+SR
Sbjct: 471 SDATSSR 477


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  157 bits (396), Expect = 3e-38
 Identities = 144/567 (25%), Positives = 257/567 (45%), Gaps = 60/567 (10%)

Query: 3   FEELLSQVGGLGRFQ--MLHLVFILPSLMLLIPHILLENFAAAIPGHRC---WVHMLDNN 57
           F  LL  VG  G FQ  ++ L FI PS+M     +  ++F        C   W+  +  +
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFI-PSIMSAF-FMFADHFVFTAQKPYCNTSWILAVGPH 109

Query: 58  TGSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCV 117
                    LS+   L ++IP   N     C  ++   W L     +I      DT+ C 
Sbjct: 110 ---------LSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNL----DSIIQFGLNDTDTCQ 156

Query: 118 DGWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILR 177
           DGW+Y  +   S ++ ++DLVC  ++ K   Q + + G+ +G +I   ++D+ GR   + 
Sbjct: 157 DGWIYPDAKKRS-LINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAIL 215

Query: 178 WCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMII---ISNNSLPITEWIRPNSKALVV 234
             LL L I     AF  +F +Y   RF  G S  ++   IS+ SL  TEW+    +A  +
Sbjct: 216 LSLLGLIIFGFGTAFMNSFHLYLFFRF--GISQSVVGYAISSISLA-TEWLVGEHRAHAI 272

Query: 235 ILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDE 294
           IL     ++G ++L G+AY    WQ L +V  +    F      L ES RWL++  K+ E
Sbjct: 273 ILGHCFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKE 332

Query: 295 GLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTT---VCDLFRNPSMRKRIC 351
             + L   A          ++N + + S + +EL   + K T   V D  +N  + K   
Sbjct: 333 AKQVLCYAA----------SVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTL 382

Query: 352 ILVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQIL 411
           ++  + F  +  ++   + ++ +G ++    V+   + +  R   +  L  +GR+ S  +
Sbjct: 383 VMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAV 442

Query: 412 FMFLVGLSILANTFVPK---------------EMQTLRVALACLGIGCSAATFSSVAVHF 456
            +    +  L   F+P+               E++++ + +  L     AAT +   ++ 
Sbjct: 443 TLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYT 502

Query: 457 IELIPTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLP 516
            EL+PTVLRA   G+   AS  GA L+  +++ T   + LP  +  +  I+   +  LLP
Sbjct: 503 AELLPTVLRATGLGLVSLASVAGAILSLTIISQTP--SLLPIFLCCVLAIVAFSLSSLLP 560

Query: 517 ETKNLPLPDTI---KDVENQKKNLKEK 540
           ET++ PL +++     + N+ K++K K
Sbjct: 561 ETRDQPLSESLNHSSQIRNKVKDMKTK 587


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  152 bits (385), Expect = 6e-37
 Identities = 146/547 (26%), Positives = 232/547 (42%), Gaps = 66/547 (12%)

Query: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLI--PHILLENFAAAIPGHRCWVHMLDNNT 58
           M  EE    VG +G +QM +L F+L  L+ L      +L     A P +   +  L  N 
Sbjct: 1   MEVEEAFQAVGEMGIYQM-YLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQ 59

Query: 59  GSGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVD 118
             GN++    ED                         W L      IH            
Sbjct: 60  SHGNQSA--GEDQAFG--------------------DWLLTANGSEIHKH---------- 87

Query: 119 GWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRW 178
             V+  S F S I ++W L+ +     S       +G+ VG I  G +SDRFGR+ +   
Sbjct: 88  --VHFSSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLT 144

Query: 179 CLLQLAITDTCAAFAPTFPVYCVLRFLAGFSS------MIIISNNSLPITEWIRPNSKAL 232
                 +      F+P++  + V RFL G  +        ++ N  +    W    S   
Sbjct: 145 GFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGG 204

Query: 233 VVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKL 292
           +      A+ I Q  L  L Y  R W+TL ++ ++   V FLLS ++ ES RWL    +L
Sbjct: 205 LFF----AVGIAQYAL--LGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRL 258

Query: 293 DEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICI 352
            E  +AL  +A+ N       +L     RS  +          +  DLFR   +     I
Sbjct: 259 SEAEEALYLIAKRNRKLKCTFSLTHPANRSCRETG--------SFLDLFRYRVLLGHTLI 310

Query: 353 LVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVAL--IVRCLALLTLNHMGRRISQI 410
           L+F+ F  ++ +YG  ++   +G +I+    L G + +     C+ L+     GR+ +  
Sbjct: 311 LMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS 370

Query: 411 LFMFLVGLSILANTFVPKEMQTLRVA------LACLGIGCSAATFSSVAVHFIELIPTVL 464
            F+ L GL+ L   F+P++  T   A      L+ LG    +A F+ V ++  EL PTV+
Sbjct: 371 AFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVI 430

Query: 465 RARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLP 524
           R    G     SR+G  +AP + +L     +LP+I++G   +  GL+  LLPET N PL 
Sbjct: 431 RNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLL 490

Query: 525 DTIKDVE 531
           +T  D++
Sbjct: 491 ETFSDLQ 497


>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  130 bits (327), Expect = 3e-30
 Identities = 113/429 (26%), Positives = 197/429 (45%), Gaps = 35/429 (8%)

Query: 131 IVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCA 190
           +V+KWDLVCD      + +F LL G++ G +I G ++D  GRR +L + ++ + I     
Sbjct: 215 VVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTV 274

Query: 191 AFAPTFPVYCVLRFLAGFS-SMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILG 249
           A +    ++  LRF  GF  + II++  +L I E   P  + ++ +++S     GQ ++ 
Sbjct: 275 ALSVNVTMFSTLRFFEGFCLAGIILTLYALRI-ELCPPGKRFMITMVASFVAMAGQFLMP 333

Query: 250 GLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIK 309
           GLA + RDWQ L  +   PF +  L      ES RWL+ T + +   + +    + N + 
Sbjct: 334 GLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRM- 392

Query: 310 NAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGT-- 367
           N E   +I+ V   +++EL     K  +  +    ++ K I +L      N++  YG   
Sbjct: 393 NPEG--DIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLC----VNSLTGYGIHH 446

Query: 368 --MVNLQHVGSNIFLLQVLYG-----AVALIVRCLAL-LTLNHMGRRISQILFMFLVGLS 419
               ++      + LL+  Y      A   +V CLA+ + +  +GRR   +LFM L  L+
Sbjct: 447 CFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALA 506

Query: 420 ILAN----TFVPKEMQ------------TLRVALACLGIGCSAATFSSVAVHFIELIPTV 463
            L        + K  Q               +A + +G+  S A  S       E+ PTV
Sbjct: 507 SLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTV 566

Query: 464 LRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPL 523
           +R    G+ L ++  G   AP++         L  II+    +I  + + LLPE+++  L
Sbjct: 567 IRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNL 626

Query: 524 PDTIKDVEN 532
           P+ I + E+
Sbjct: 627 PENISNGEH 635


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  111 bits (278), Expect = 1e-24
 Identities = 112/431 (25%), Positives = 179/431 (41%), Gaps = 16/431 (3%)

Query: 112 DTEPCVDGWVYDQ-SYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRF 170
           D   C+  W Y+      +  + +WDLVCD      + Q L + G   G +  G+ +DRF
Sbjct: 66  DFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRF 125

Query: 171 GRRFILRWCLLQLAITDTC---AAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRP 227
           GRR I+   LL L +   C    A A +      LRFL GF    +     L   E   P
Sbjct: 126 GRRGIV---LLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDP 182

Query: 228 NSKALVVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVP--FFVFFLLSRWLVESARW 285
             +  V +        G  +  GLA V +DW+ L  + + P   F+F+      +ESARW
Sbjct: 183 TQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARW 242

Query: 286 LIITNKLDEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDA---AQTKTTVCDLFR 342
           LI+  +++E    LR +A  N  +   + L  E   +    E      A +  +   L  
Sbjct: 243 LIVKRQIEEAQSVLRILAERN--RPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLN 300

Query: 343 NPSMRKRICILVFLRF-ANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLN 401
             ++ K + IL F  F A+ I      V      S+ +L  +L    A +      +T++
Sbjct: 301 YRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVD 360

Query: 402 HMGRRISQILFMFLVGLSILANTFVPKEMQTLRV-ALACLGIGCSAATFSSVAVHFIELI 460
             GRR   +L M L G++ L    +   +    +   + LG+  S A      +   E+I
Sbjct: 361 RFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVI 420

Query: 461 PTVLRARASGIDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKN 520
           PT +R R  G+ +    +G    P           L  ++     ++  L + LLPETK 
Sbjct: 421 PTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKR 480

Query: 521 LPLPDTIKDVE 531
             LP+ ++D E
Sbjct: 481 KLLPEVLRDGE 491


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.141    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,232,769
Number of Sequences: 37866
Number of extensions: 750005
Number of successful extensions: 2310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2153
Number of HSP's gapped (non-prelim): 81
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.