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Search of human proteins with 148277037
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148277037 AP2 associated kinase 1 [Homo sapiens]
(961 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148277037 AP2 associated kinase 1 [Homo sapiens] 1922 0.0
gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens] 667 0.0
gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens] 664 0.0
gi|157384971 cyclin G associated kinase [Homo sapiens] 192 1e-48
gi|57165436 serine/threonine kinase 16 [Homo sapiens] 112 1e-24
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 107 5e-23
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 106 1e-22
gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens] 100 9e-21
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 100 9e-21
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 98 3e-20
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 98 3e-20
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 98 3e-20
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 97 7e-20
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 95 4e-19
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 95 4e-19
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 95 4e-19
gi|221139761 zinc finger protein 853 [Homo sapiens] 90 1e-17
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 90 1e-17
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 89 3e-17
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 87 6e-17
gi|33286444 mastermind-like 2 [Homo sapiens] 87 7e-17
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 87 1e-16
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 86 2e-16
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 85 3e-16
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 84 5e-16
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 84 6e-16
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 84 6e-16
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 83 1e-15
gi|110347429 mediator complex subunit 12 [Homo sapiens] 82 2e-15
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 82 3e-15
>gi|148277037 AP2 associated kinase 1 [Homo sapiens]
Length = 961
Score = 1922 bits (4980), Expect = 0.0
Identities = 961/961 (100%), Positives = 961/961 (100%)
Query: 1 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV 60
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
Sbjct: 1 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV 60
Query: 61 FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW 120
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
Sbjct: 61 FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW 120
Query: 121 EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE 180
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
Sbjct: 121 EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE 180
Query: 181 NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT 240
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
Sbjct: 181 NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT 240
Query: 241 TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK 300
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
Sbjct: 241 TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK 300
Query: 301 RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT 360
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
Sbjct: 301 RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT 360
Query: 361 ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP 420
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
Sbjct: 361 ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP 420
Query: 421 QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP 480
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
Sbjct: 421 QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP 480
Query: 481 AQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ 540
AQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
Sbjct: 481 AQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ 540
Query: 541 QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ 600
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
Sbjct: 541 QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ 600
Query: 601 PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA 660
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
Sbjct: 601 PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA 660
Query: 661 AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG 720
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
Sbjct: 661 AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG 720
Query: 721 EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI 780
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
Sbjct: 721 EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI 780
Query: 781 PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV 840
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
Sbjct: 781 PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV 840
Query: 841 PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL 900
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
Sbjct: 841 PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL 900
Query: 901 ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID 960
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
Sbjct: 901 ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID 960
Query: 961 L 961
L
Sbjct: 961 L 961
>gi|38787935 BMP-2 inducible kinase isoform a [Homo sapiens]
Length = 1161
Score = 667 bits (1721), Expect = 0.0
Identities = 391/776 (50%), Positives = 474/776 (61%), Gaps = 99/776 (12%)
Query: 1 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIG-----RVFGIGRQQVTVDEVLAEG 55
MKKF + +GGSG G+ G GG+ +G G G G RVF +GR QVT++E LAEG
Sbjct: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
Query: 56 GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS 115
GF+ VFLVRT G++CALKRM+VNN DL VCKREI IM++LSGHKNIVGY+D ++N++S
Sbjct: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
Query: 116 SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR 175
+VWEVLILM++CR GQVVN MN++LQTGFTE EVLQIFCDTCEAVARLHQCKTPIIHR
Sbjct: 121 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 179
Query: 176 DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS 235
DLKVENILL+D G+YVLCDFGSATNKF NPQ +GVN VE+EIKKYTTLSYRAPEM+NLY
Sbjct: 180 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 239
Query: 236 GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE 295
GK ITTKADIWALGCLLYKLC+FTLPFGESQVAICDGNFTIPDNSRYS+++HCLIR+MLE
Sbjct: 240 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 299
Query: 296 PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD 355
PDP+ RPDI+QVSYF+FK KK+CP+ N+ NS IP+ LPEP+ ASEAAA+K+Q KAR+TD
Sbjct: 300 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 359
Query: 356 PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS 414
I TETSIAPRQRPKA T P +L IQ + TP K P G+ G L
Sbjct: 360 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 415
Query: 415 VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ 471
P+ Q PP QP PQ QQ + Q HQQQ +Q
Sbjct: 416 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 464
Query: 472 QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF 531
QQQQQQ QQQ QQQQ Q QQ H L+Q+
Sbjct: 465 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 499
Query: 532 YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP 591
Y QQ Q QQQQ LQQ+ M + QPQP + P P +
Sbjct: 500 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQQ 542
Query: 592 AI---QAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVP 648
A Q + QP Q P LT P S S +P
Sbjct: 543 AFFQQQMLAQHQPSQQQASPE--------YLTSPQE-----------FSPALVSYTSSLP 583
Query: 649 ASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTA 708
A T + ++S + ++S + + T+Q+N+ NP + S WNPF +DNFSKLT
Sbjct: 584 AQVGTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTE 637
Query: 709 EELLNKDFAKLGEGKHPEKLGG--SAESLIPGFQSTQGDAFATTSF--SAGTAEKR 760
EELL+++F L + E+ + +SL D F + F +G+ EK+
Sbjct: 638 EELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKK 693
>gi|38787904 BMP-2 inducible kinase isoform b [Homo sapiens]
Length = 662
Score = 664 bits (1713), Expect = 0.0
Identities = 383/735 (52%), Positives = 458/735 (62%), Gaps = 95/735 (12%)
Query: 1 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIG-----RVFGIGRQQVTVDEVLAEG 55
MKKF + +GGSG G+ G GG+ +G G G G RVF +GR QVT++E LAEG
Sbjct: 1 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 60
Query: 56 GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS 115
GF+ VFLVRT G++CALKRM+VNN DL VCKREI IM++LSGHKNIVGY+D ++N++S
Sbjct: 61 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 120
Query: 116 SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR 175
+VWEVLILM++CR GQVVN MN++LQTGFTE EVLQIFCDTCEAVARLHQCKTPIIHR
Sbjct: 121 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 179
Query: 176 DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS 235
DLKVENILL+D G+YVLCDFGSATNKF NPQ +GVN VE+EIKKYTTLSYRAPEM+NLY
Sbjct: 180 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 239
Query: 236 GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE 295
GK ITTKADIWALGCLLYKLC+FTLPFGESQVAICDGNFTIPDNSRYS+++HCLIR+MLE
Sbjct: 240 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 299
Query: 296 PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD 355
PDP+ RPDI+QVSYF+FK KK+CP+ N+ NS IP+ LPEP+ ASEAAA+K+Q KAR+TD
Sbjct: 300 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 359
Query: 356 PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS 414
I TETSIAPRQRPKA T P +L IQ + TP K P G+ G L
Sbjct: 360 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 415
Query: 415 VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ 471
P+ Q PP QP PQ QQ + Q HQQQ +Q
Sbjct: 416 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 464
Query: 472 QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF 531
QQQQQQ QQQ QQQQ Q QQ H L+Q+
Sbjct: 465 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 499
Query: 532 YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP 591
Y QQ Q QQQQ LQQ+ M + QPQP + P P +
Sbjct: 500 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQQ 542
Query: 592 AI---QAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVP 648
A Q + QP Q P LT P S S +P
Sbjct: 543 AFFQQQMLAQHQPSQQQASPE--------YLTSPQE-----------FSPALVSYTSSLP 583
Query: 649 ASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTA 708
A T + ++S + ++S + + T+Q+N+ NP + S WNPF +DNFSKLT
Sbjct: 584 AQVGTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTE 637
Query: 709 EELLNKDFAKLGEGK 723
EELL+++F L K
Sbjct: 638 EELLDREFDLLRSSK 652
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 192 bits (488), Expect = 1e-48
Identities = 117/299 (39%), Positives = 168/299 (56%), Gaps = 10/299 (3%)
Query: 17 GSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKR 75
G GS GG S ++G+ +G ++ V VLAEGGFA V+ + +G + ALKR
Sbjct: 13 GPGSLGGASGRDQ--SDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKR 70
Query: 76 MFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW--EVLILMDFCRGGQ 133
+ N E + +E+ M+ LSGH NIV + ++ D E L+L + C+G
Sbjct: 71 LLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 130
Query: 134 VVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLC 193
V L + + + VL+IF TC AV +H+ K PIIHRDLKVEN+LL ++G LC
Sbjct: 131 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLC 190
Query: 194 DFGSATNKFQNP----QTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALG 249
DFGSAT P + VE+EI + TT YR PE+++LYS I K DIWALG
Sbjct: 191 DFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALG 250
Query: 250 CLLYKLCYFTLPFGE-SQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 307
C+LY LC+ PF + +++ I +G ++IP + H LIR ML+ +P++R I +V
Sbjct: 251 CILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 309
>gi|57165436 serine/threonine kinase 16 [Homo sapiens]
Length = 305
Score = 112 bits (281), Expect = 1e-24
Identities = 80/263 (30%), Positives = 129/263 (49%), Gaps = 15/263 (5%)
Query: 52 LAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSS 110
L EGGF+ V LV +G ALKR+ + + D + +RE + R L H NI+ +
Sbjct: 26 LGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHR-LFNHPNILRLVAYC 84
Query: 111 INNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG--FTENEVLQIFCDTCEAVARLHQC 168
+ G E +L+ F + G + N + + G TE+++L + C + +H
Sbjct: 85 LRE--RGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHA- 141
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTTLSYRA 227
HRDLK NILL D G VL D GS + + + ++D + T+SYRA
Sbjct: 142 -KGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRA 200
Query: 228 PEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF------GESQVAICDGNFTIPDNSR 281
PE+ ++ S +I + D+W+LGC+LY + + P+ G+S +IP + R
Sbjct: 201 PELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPR 260
Query: 282 YSQDMHCLIRYMLEPDPDKRPDI 304
+S + L+ M+ DP +RP I
Sbjct: 261 HSSALRQLLNSMMTVDPHQRPHI 283
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 107 bits (267), Expect = 5e-23
Identities = 95/331 (28%), Positives = 155/331 (46%), Gaps = 46/331 (13%)
Query: 52 LAEGGFAIVFLVR-TSNGMKCALKRMFVN--NEHDLQVCKREIQIMRDLSGHKNIVGYID 108
+ EG F LV+ T +G + +K + ++ + + + +RE+ ++ ++ H NIV Y +
Sbjct: 10 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK-HPNIVQYRE 68
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
S N S + I+MD+C GG + +N + F E+++L F C A+ +H
Sbjct: 69 SFEENGS------LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 122
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 228
K I+HRD+K +NI L G L DFG A + N + VE T Y +P
Sbjct: 123 K--ILHRDIKSQNIFLTKDGTVQLGDFGIA--RVLN------STVELARTCIGTPYYLSP 172
Query: 229 EMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYS 283
E + K K+DIWALGC+LY+LC F + I G+F P + YS
Sbjct: 173 E---ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFP-PVSLHYS 228
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQV-----------SYFSFKLLKKECPIPNVQ---NSPI 329
D+ L+ + + +P RP + + + S +L+ +E + + PI
Sbjct: 229 YDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPI 288
Query: 330 PAKLPEPVKASEA---AAKKTQPKARLTDPI 357
PAK P + S + A K T+P A+ P+
Sbjct: 289 PAKRPASGQNSISVMPAQKITKPAAKYGIPL 319
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 106 bits (264), Expect = 1e-22
Identities = 115/525 (21%), Positives = 216/525 (41%), Gaps = 75/525 (14%)
Query: 48 VDEVLAEGGFAIVFLVRTSNGMK-CALKRMFVNNE----HDLQVCKREIQIMRDLSGHKN 102
V + + +G F +L + + K C +K +N E + + K+E+ ++ + H N
Sbjct: 6 VIKAIGQGAFGKAYLAKGKSDSKHCVIKE--INFEKMPIQEKEASKKEVILLEKMK-HPN 62
Query: 103 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 162
IV + +S N + I+M++C GG ++ +N++ F+E+++L F +
Sbjct: 63 IVAFFNSFQEN------GRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGL 116
Query: 163 ARLHQCKTPIIHRDLKVENILLHDRGHYV-LCDFGSATNKFQNPQTEGVNAVEDEIKKYT 221
+H K I+HRD+K +NI L G L DFG A + N N++E
Sbjct: 117 KHIHDRK--ILHRDIKAQNIFLSKNGMVAKLGDFGIA--RVLN------NSMELARTCIG 166
Query: 222 TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTI 276
T Y +PE+ K K DIW+LGC+LY+LC PF + + IC +F
Sbjct: 167 TPYYLSPEICQ---NKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFA- 222
Query: 277 PDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV-----------SYFSFKLLKKECPIPNVQ 325
P + +S+++H LI + + P RP I + Y + +++++E +
Sbjct: 223 PISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLIC 282
Query: 326 NSPIPA-----KLPEPVKASEAAAK-KTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNP 379
+ PA K+ + K + + K P++R++ PI RP AG
Sbjct: 283 RAGAPASRHAGKVVQKCKIQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAG------ 336
Query: 380 GILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAP 439
A R ++ P AA + A + + + +A +P
Sbjct: 337 -------AQKARSIKMIERPKIAAVCGHYDYYYAQL-----------DMLRRRAHKPSYH 378
Query: 440 PTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQ 499
P PQ+ + G + +P +L+++ + QQ ++ G + Q
Sbjct: 379 PIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLRPSSAEPNYNQ 438
Query: 500 FQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQ 544
Q + ++P + P +Q+ + + +QQ ++
Sbjct: 439 RQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKE 483
>gi|51477700 mediator complex subunit 15 isoform a [Homo sapiens]
Length = 788
Score = 100 bits (248), Expect = 9e-21
Identities = 93/248 (37%), Positives = 112/248 (45%), Gaps = 39/248 (15%)
Query: 394 ATVQPPPQAAGSS-NQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQG 452
A + PP+ G S G L ++ QP + QP P T P +
Sbjct: 97 AGIGMPPRGPGQSLGGMGSLGAMGQPMSLS--GQPPPGTSGMAPHS-------------- 140
Query: 453 LPAQAQATPQHQ---QQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQ 509
+ + ATPQ Q QQ+ L+QQQQQQQ QQQ A QQQQ Q QQFQA A QQ
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQQFQ--QQQQAALQQQQQQQQQQQFQAQQSAMQQ 198
Query: 510 PAIA----QFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQ 565
A Q + Q QQ L++ +Q QQQ QQQQQQ Q L QQ QQ QQ
Sbjct: 199 QFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQ 258
Query: 566 KPTMAAGQQP--QPQPAAAPQPAPAQEPAIQAPVRQ-------QPKVQTTPPPAVQGQKV 616
+ A QP Q P PQP P+Q A+ ++Q QP Q PP Q Q
Sbjct: 259 QQQQALQAQPPIQQPPMQQPQPPPSQ--ALPQQLQQMHHTQHHQPPPQPQQPPVAQNQP- 315
Query: 617 GSLTPPSS 624
S PP S
Sbjct: 316 -SQLPPQS 322
Score = 70.9 bits (172), Expect = 6e-12
Identities = 83/288 (28%), Positives = 108/288 (37%), Gaps = 38/288 (13%)
Query: 374 QTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQ--- 430
Q Q I +Q +++ Q Q A + P + P +PQ PPSQ LPQ
Sbjct: 234 QQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPP--IQQPPMQQPQPPPSQALPQQLQ 291
Query: 431 ----TQAKQPQAPPTPQQTPSTQAQG--LPAQAQATPQHQQQLFLKQQQQQQQPP----- 479
TQ QP PP PQQ P Q Q LP Q+Q P Q L Q QPP
Sbjct: 292 QMHHTQHHQP--PPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVR 349
Query: 480 ---PAQQQPAGTFYQQQQAQTQQFQA---VHPATQQ--PAIAQ--------FPVVSQGGS 523
QQ P QQQQ Q QA V P Q A+AQ FP + +
Sbjct: 350 APMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSA 409
Query: 524 QQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQ-KPTMAAGQ---QPQPQP 579
+Q Q Q L++ QQ+ T Q+ +P+ GQ QP
Sbjct: 410 IPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNV 469
Query: 580 AAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKT 627
++ P P+P+ +P Q V P G L P +P +
Sbjct: 470 SSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 517
Score = 64.7 bits (156), Expect = 4e-10
Identities = 113/395 (28%), Positives = 144/395 (36%), Gaps = 86/395 (21%)
Query: 359 TTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQP 418
T +T + +Q Q Q Q AL +++ Q QA S+ Q A V Q
Sbjct: 148 TPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQ- 206
Query: 419 KPQAPPSQPLPQTQAKQP---QAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQ 475
Q L Q Q +Q + QQ Q Q L AQ Q QQQ +QQQQQ
Sbjct: 207 ------QQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ--QQQQQQ 258
Query: 476 QQ------PPPAQQQPAGTFYQQQ----QAQTQQFQAVH--------PATQQPAIAQ--- 514
QQ PP QQ P Q Q QA QQ Q +H P QQP +AQ
Sbjct: 259 QQQQALQAQPPIQQPP---MQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQP 315
Query: 515 ---------FPVVSQGGSQQQLMQNFYQQQ-----------QQQQQQQQQQQLATALHQQ 554
P+VSQ +Q Q Y Q QQ Q Q QQ TA+
Sbjct: 316 SQLPPQSQTQPLVSQ--AQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTA 373
Query: 555 QLMTQQAALQQKPTMAAGQQPQPQPAA-APQPAPAQEPAIQAPVRQQPKVQ--------- 604
Q A Q T A Q A P A + P+ P+ +QP Q
Sbjct: 374 QAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPML 433
Query: 605 TTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEAS 664
++P P Q Q S+ PP P Q G P+S+ + + A +
Sbjct: 434 SSPSPGQQVQTPQSMPPPPQPSPQP----------------GQPSSQPNSNVSSGPAPSP 477
Query: 665 LNKSKSATTTPSGSPRTSQ--QNVYNPSEGSTWNP 697
+ S + PS SP T++ QN PS G P
Sbjct: 478 SSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTP 512
Score = 38.9 bits (89), Expect = 0.023
Identities = 38/152 (25%), Positives = 53/152 (34%), Gaps = 5/152 (3%)
Query: 329 IPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPR-QRPKAGQTQPNPGILPIQPA 387
I A+ P P A A + P R P+ S P P GQ P +P P
Sbjct: 397 IRARFP-PTTAVSAIPSSSIPLGR--QPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQ 453
Query: 388 LTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPS 447
+P+ P S P + +P P PQ S +T P P TP
Sbjct: 454 PSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPV 513
Query: 448 TQAQGLPAQAQATPQHQQQL-FLKQQQQQQQP 478
+ + + + QQ L LKQ + +P
Sbjct: 514 NPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEP 545
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 100 bits (248), Expect = 9e-21
Identities = 93/248 (37%), Positives = 112/248 (45%), Gaps = 39/248 (15%)
Query: 394 ATVQPPPQAAGSS-NQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQG 452
A + PP+ G S G L ++ QP + QP P T P +
Sbjct: 97 AGIGMPPRGPGQSLGGMGSLGAMGQPMSLS--GQPPPGTSGMAPHS-------------- 140
Query: 453 LPAQAQATPQHQ---QQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQ 509
+ + ATPQ Q QQ+ L+QQQQQQQ QQQ A QQQQ Q QQFQA A QQ
Sbjct: 141 MAVVSTATPQTQLQLQQVALQQQQQQQQFQ--QQQQAALQQQQQQQQQQQFQAQQSAMQQ 198
Query: 510 PAIA----QFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQ 565
A Q + Q QQ L++ +Q QQQ QQQQQQ Q L QQ QQ QQ
Sbjct: 199 QFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQ 258
Query: 566 KPTMAAGQQP--QPQPAAAPQPAPAQEPAIQAPVRQ-------QPKVQTTPPPAVQGQKV 616
+ A QP Q P PQP P+Q A+ ++Q QP Q PP Q Q
Sbjct: 259 QQQQALQAQPPIQQPPMQQPQPPPSQ--ALPQQLQQMHHTQHHQPPPQPQQPPVAQNQP- 315
Query: 617 GSLTPPSS 624
S PP S
Sbjct: 316 -SQLPPQS 322
Score = 87.4 bits (215), Expect = 6e-17
Identities = 100/344 (29%), Positives = 128/344 (37%), Gaps = 77/344 (22%)
Query: 397 QPPPQAAGSSNQPGLLASVPQPKPQ-----APPSQPLPQTQAKQPQAPPTPQQTPSTQAQ 451
QPPP +G + + S P+ Q Q Q Q +Q Q QQ Q Q
Sbjct: 128 QPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQ 187
Query: 452 GLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQ-QQQAQTQQFQAVHPATQQP 510
AQ Q+ Q Q Q ++QQQQ QQ QQ +Q QQQ Q QQ Q
Sbjct: 188 QFQAQ-QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQL-------- 238
Query: 511 AIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMA 570
Q++ Q QQQQQQQQQQQQQ QQQ + Q +QQ P
Sbjct: 239 --------------QRIAQLQLQQQQQQQQQQQQQ-------QQQALQAQPPIQQPPM-- 275
Query: 571 AGQQPQPQPAAA---------------PQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQK 615
QQPQP P+ A P P P Q P Q Q P T P Q Q
Sbjct: 276 --QQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQA 333
Query: 616 V-GSL-----------------TPPSSPKTQRAGHRRILSDVTHSAVFGVPASKST-QLL 656
+ G + PP P+ Q+ + GV S+S+ +L
Sbjct: 334 LPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPML 393
Query: 657 QAAAAEASLNKSKSATTTPSGSPRTSQ---QNVYNPSEGSTWNP 697
+ + + +S P SP+ Q Q N S G +P
Sbjct: 394 SSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSP 437
Score = 63.2 bits (152), Expect = 1e-09
Identities = 68/235 (28%), Positives = 90/235 (38%), Gaps = 26/235 (11%)
Query: 417 QPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQ- 475
Q + Q Q Q Q + QA P QQ P Q Q P +QA PQ QQ+ Q Q
Sbjct: 245 QLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQ--PPPSQALPQQLQQMHHTQHHQPP 302
Query: 476 ---QQPPPAQQQPAGTFYQQQ------QAQTQQFQAVHPA-----TQQPAIAQFPVVSQG 521
QQPP AQ QP+ Q Q QAQ Q ++ + P + Q P V
Sbjct: 303 PQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQ 362
Query: 522 GSQQQLMQNFYQQQQQ-----QQQQQQQQQLATALHQQQLMTQQAALQQ-KPTMAAGQ-- 573
QQQ Q Q Q Q L++ QQ+ T Q+ +P+ GQ
Sbjct: 363 VQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPS 422
Query: 574 -QPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKT 627
QP ++ P P+P+ +P Q V P G L P +P +
Sbjct: 423 SQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSS 477
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/188 (21%), Positives = 72/188 (38%), Gaps = 3/188 (1%)
Query: 294 LEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLP-EPVKASEAAAKKTQPKAR 352
L P +P + Q ++L + P+ V+ + + P +P + A +T A+
Sbjct: 318 LPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQ 377
Query: 353 LTDP-IPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGL 411
+ P + +++S+ P GQ P +P P +P+ P S P
Sbjct: 378 MVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSP 437
Query: 412 LASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQL-FLK 470
+ +P P PQ S +T P P TP + + + + QQ L LK
Sbjct: 438 SSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLK 497
Query: 471 QQQQQQQP 478
Q + +P
Sbjct: 498 QLSKYIEP 505
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 98.2 bits (243), Expect = 3e-20
Identities = 152/683 (22%), Positives = 258/683 (37%), Gaps = 94/683 (13%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K+EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KQEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G+ ++ ++M+FC G V +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH 147
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
K +IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 148 K--VIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++DIW+LG + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDIWSLGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + + F C I + P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFIDF---IDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + T + + + +
Sbjct: 294 TER-QVRIQLKDHI--------DRSRKKRGEKEE-----------TEYEYSGSEEEDDSH 333
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQH 463
G +P + +VP L Q +A QQ Q + A + H
Sbjct: 334 GEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHL-LH 392
Query: 464 QQQLFLKQQQQQQQPPPAQQ----QPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVS 519
Q+Q +++Q+++++ QQ + ++QQ + + QA+ ++ +
Sbjct: 393 QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 520 QGGSQQQLMQNFYQQQQQQ--------QQQQQQQQLATALHQQQLMTQQAALQQKPTMAA 571
+ ++Q Q+Q QQ QQQQQQQQL QQ L + L
Sbjct: 453 RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH---YGR 509
Query: 572 GQQPQPQPAAAPQPAPAQEPAIQ--APVRQQPKVQTTPPPAVQGQKVG-----SLTPPSS 624
G P +PA A + Q +P+ + T P P + G S TPP
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQ 569
Query: 625 --PKTQRAGHRRILSDVTHSAVFGVPASKSTQL-----LQAAAAEASLNKS---KSATTT 674
+ Q H+ +++ + P +S L AA AS + + T T
Sbjct: 570 RPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTAT 629
Query: 675 PSGSPRTSQQNVYNPSEGSTWNP 697
PS +QN SEG +P
Sbjct: 630 PSARGAVIRQNSDPTSEGPGPSP 652
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 98.2 bits (243), Expect = 3e-20
Identities = 152/683 (22%), Positives = 258/683 (37%), Gaps = 94/683 (13%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K+EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KQEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G+ ++ ++M+FC G V +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH 147
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
K +IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 148 K--VIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++DIW+LG + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDIWSLGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + + F C I + P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFIDF---IDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + T + + + +
Sbjct: 294 TER-QVRIQLKDHI--------DRSRKKRGEKEE-----------TEYEYSGSEEEDDSH 333
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQH 463
G +P + +VP L Q +A QQ Q + A + H
Sbjct: 334 GEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHL-LH 392
Query: 464 QQQLFLKQQQQQQQPPPAQQ----QPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVS 519
Q+Q +++Q+++++ QQ + ++QQ + + QA+ ++ +
Sbjct: 393 QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 520 QGGSQQQLMQNFYQQQQQQ--------QQQQQQQQLATALHQQQLMTQQAALQQKPTMAA 571
+ ++Q Q+Q QQ QQQQQQQQL QQ L + L
Sbjct: 453 RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH---YGR 509
Query: 572 GQQPQPQPAAAPQPAPAQEPAIQ--APVRQQPKVQTTPPPAVQGQKVG-----SLTPPSS 624
G P +PA A + Q +P+ + T P P + G S TPP
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQ 569
Query: 625 --PKTQRAGHRRILSDVTHSAVFGVPASKSTQL-----LQAAAAEASLNKS---KSATTT 674
+ Q H+ +++ + P +S L AA AS + + T T
Sbjct: 570 RPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTAT 629
Query: 675 PSGSPRTSQQNVYNPSEGSTWNP 697
PS +QN SEG +P
Sbjct: 630 PSARGAVIRQNSDPTSEGPGPSP 652
Score = 40.8 bits (94), Expect = 0.006
Identities = 67/293 (22%), Positives = 101/293 (34%), Gaps = 45/293 (15%)
Query: 405 SSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTP--STQAQGLPAQAQATPQ 462
+ ++PG P P PQA P P P +Q Q P PQ+ P S A +P + A P
Sbjct: 538 AKSKPGSTGPEP-PIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
Query: 463 HQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVH----PATQQPAIAQFPVV 518
+ Q Q + PA P + + + P ++ P
Sbjct: 597 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGP-------- 648
Query: 519 SQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQ 578
G S + + Q+ +ATAL+ T AG +
Sbjct: 649 --GPSPNPPAWVRPDNEAPPKVPQRTSSIATALN---------------TSGAGGS---R 688
Query: 579 PAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSD 638
PA A + P A Q ++++ + T PP Q G S+P +R+ SD
Sbjct: 689 PAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSD 748
Query: 639 VTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSE 691
+PAS L QA + E ++ P SP S N P +
Sbjct: 749 SV------LPASHG-HLPQAGSLE---RNRVGVSSKPDSSPVLSPGNKAKPDD 791
Score = 35.0 bits (79), Expect = 0.34
Identities = 49/202 (24%), Positives = 76/202 (37%), Gaps = 46/202 (22%)
Query: 325 QNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGIL-- 382
QNSP+ P + P+A P P ++T P QRP Q P+ ++
Sbjct: 533 QNSPLAKSKP-----GSTGPEPPIPQASPGPPGPLSQTP--PMQRPVEPQEGPHKSLVAH 585
Query: 383 --PIQPALTPRKR----------------ATVQPPPQAAGSSNQPGLLASV----PQPKP 420
P++P P R A+ P P + P +V P
Sbjct: 586 RVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTS 645
Query: 421 QAPPSQPLPQTQAKQP-QAPPTPQQTPSTQAQGL---------PAQA-QATPQHQQ--QL 467
+ P P P + +APP Q S+ A L PAQA +A P+ Q+
Sbjct: 646 EGPGPSPNPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQI 705
Query: 468 FLKQQQQQ--QQPPPAQQQPAG 487
+L+++ ++ +PP QP G
Sbjct: 706 YLQRRAERGTPKPPGPPAQPPG 727
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 98.2 bits (243), Expect = 3e-20
Identities = 152/683 (22%), Positives = 258/683 (37%), Gaps = 94/683 (13%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K+EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KQEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G+ ++ ++M+FC G V +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH 147
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
K +IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 148 K--VIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++DIW+LG + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDIWSLGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + + F C I + P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFIDF---IDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + T + + + +
Sbjct: 294 TER-QVRIQLKDHI--------DRSRKKRGEKEE-----------TEYEYSGSEEEDDSH 333
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQH 463
G +P + +VP L Q +A QQ Q + A + H
Sbjct: 334 GEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHL-LH 392
Query: 464 QQQLFLKQQQQQQQPPPAQQ----QPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVS 519
Q+Q +++Q+++++ QQ + ++QQ + + QA+ ++ +
Sbjct: 393 QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 520 QGGSQQQLMQNFYQQQQQQ--------QQQQQQQQLATALHQQQLMTQQAALQQKPTMAA 571
+ ++Q Q+Q QQ QQQQQQQQL QQ L + L
Sbjct: 453 RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH---YGR 509
Query: 572 GQQPQPQPAAAPQPAPAQEPAIQ--APVRQQPKVQTTPPPAVQGQKVG-----SLTPPSS 624
G P +PA A + Q +P+ + T P P + G S TPP
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQ 569
Query: 625 --PKTQRAGHRRILSDVTHSAVFGVPASKSTQL-----LQAAAAEASLNKS---KSATTT 674
+ Q H+ +++ + P +S L AA AS + + T T
Sbjct: 570 RPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTAT 629
Query: 675 PSGSPRTSQQNVYNPSEGSTWNP 697
PS +QN SEG +P
Sbjct: 630 PSARGAVIRQNSDPTSEGPGPSP 652
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 97.1 bits (240), Expect = 7e-20
Identities = 151/674 (22%), Positives = 251/674 (37%), Gaps = 96/674 (14%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K+EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KQEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G+ ++ ++M+FC G V +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAH 147
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
K +IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 148 K--VIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++DIW+LG + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDIWSLGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + + F C I + P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFIDF---IDTCLIKTYLSRPPTEQLLKFPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + T + + + +
Sbjct: 294 TER-QVRIQLKDHI--------DRSRKKRGEKEE-----------TEYEYSGSEEEDDSH 333
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQH 463
G +P + +VP L Q +A QQ Q + A + H
Sbjct: 334 GEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHL-LH 392
Query: 464 QQQLFLKQQQQQQQPPPAQQ----QPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVS 519
Q+Q +++Q+++++ QQ + ++QQ + + QA+ ++ +
Sbjct: 393 QRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYK 452
Query: 520 QGGSQQQLMQNFYQQQQQQ--------QQQQQQQQLATALHQQQLMTQQAALQQKPTMAA 571
+ ++Q Q+Q QQ QQQQQQQQL QQ L + L
Sbjct: 453 RKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYH---YGR 509
Query: 572 GQQPQPQPAAAPQPAPAQEPAIQ--APVRQQPKVQTTPPPAVQGQKVG-----SLTPP-S 623
G P +PA A + Q +P+ + T P P + G S TPP
Sbjct: 510 GMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQ 569
Query: 624 SPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQ 683
P + G + L D + PAS A T TPS +
Sbjct: 570 RPVEPQEGPHKSLQDQPTRNLAAFPASHDPDPAIPA-----------PTATPSARGAVIR 618
Query: 684 QNVYNPSEGSTWNP 697
QN SEG +P
Sbjct: 619 QNSDPTSEGPGPSP 632
Score = 35.0 bits (79), Expect = 0.34
Identities = 45/173 (26%), Positives = 62/173 (35%), Gaps = 16/173 (9%)
Query: 318 ECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQP 377
E PIP P P L + + P L D PT + P P
Sbjct: 548 EPPIPQASPGP-PGPLSQTPPMQRPVEPQEGPHKSLQDQ-PTRNLAAFPASH------DP 599
Query: 378 NPGILPIQPALTPRKRATV---QPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAK 434
+P I P TP R V P + G P A V +P +APP +PQ +
Sbjct: 600 DPAIPA--PTATPSARGAVIRQNSDPTSEGPGPSPNPPAWV-RPDNEAPPK--VPQRTSS 654
Query: 435 QPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAG 487
A T S AQ + A+ ++ Q L + ++ +PP QP G
Sbjct: 655 IATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPG 707
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/259 (28%), Positives = 122/259 (47%), Gaps = 28/259 (10%)
Query: 51 VLAEGGFAIVFLVR--TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
++ EG F LV+ +SN M + + + Q ++E ++ + H NIV + +
Sbjct: 9 MIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKE 67
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
S + G ++ I+M++C GG ++ + Q+ F E+ +L F C V +H
Sbjct: 68 SF---EAEGHLY---IVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH-- 119
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 228
K ++HRD+K +NI L G L DFGSA NP V T Y P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPP 171
Query: 229 EMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYS 283
E ++ K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 172 E---IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYS 227
Query: 284 QDMHCLIRYMLEPDPDKRP 302
++ L++ M + +P RP
Sbjct: 228 YELQFLVKQMFKRNPSHRP 246
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/259 (28%), Positives = 122/259 (47%), Gaps = 28/259 (10%)
Query: 51 VLAEGGFAIVFLVR--TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
++ EG F LV+ +SN M + + + Q ++E ++ + H NIV + +
Sbjct: 9 MIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKE 67
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
S + G ++ I+M++C GG ++ + Q+ F E+ +L F C V +H
Sbjct: 68 SF---EAEGHLY---IVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH-- 119
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 228
K ++HRD+K +NI L G L DFGSA NP V T Y P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPP 171
Query: 229 EMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYS 283
E ++ K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 172 E---IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYS 227
Query: 284 QDMHCLIRYMLEPDPDKRP 302
++ L++ M + +P RP
Sbjct: 228 YELQFLVKQMFKRNPSHRP 246
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/259 (28%), Positives = 122/259 (47%), Gaps = 28/259 (10%)
Query: 51 VLAEGGFAIVFLVR--TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
++ EG F LV+ +SN M + + + Q ++E ++ + H NIV + +
Sbjct: 9 MIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMK-HPNIVAFKE 67
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
S + G ++ I+M++C GG ++ + Q+ F E+ +L F C V +H
Sbjct: 68 SF---EAEGHLY---IVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH-- 119
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAP 228
K ++HRD+K +NI L G L DFGSA NP V T Y P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSA-RLLSNPMAFACTYVG-------TPYYVPP 171
Query: 229 EMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYS 283
E ++ K+DIW+LGC+LY+LC PF + + +C G + P S YS
Sbjct: 172 E---IWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCIS-PLPSHYS 227
Query: 284 QDMHCLIRYMLEPDPDKRP 302
++ L++ M + +P RP
Sbjct: 228 YELQFLVKQMFKRNPSHRP 246
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 89.7 bits (221), Expect = 1e-17
Identities = 92/276 (33%), Positives = 116/276 (42%), Gaps = 33/276 (11%)
Query: 326 NSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQ 385
+SP + PV ASE A ++T+P R + E P+Q+P+ Q Q
Sbjct: 62 SSPQRPAVSAPVGASEIA-EETRPGQRELQ-LQQLEQQPEPQQQPQHEQLQQ-------- 111
Query: 386 PALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQA-------PPSQPLPQTQAKQPQA 438
P+ +Q PQ G L+ + Q K Q+ P Q + Q Q QPQ
Sbjct: 112 ----PQPHLELQQQPQQDGQQQ----LSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQ 163
Query: 439 PPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQ---QPAGTFYQQQQA 495
Q+ Q Q QAQ QQQ L+QQ Q+QQ QQ Q QQ+Q
Sbjct: 164 VQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQL 223
Query: 496 QTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQ 555
Q QQFQ QQ Q ++ Q G QL Q QQQQ Q QQQ +Q L QQ
Sbjct: 224 QQQQFQQQQEQLQQQQ--QLLLLQQQG---QLQQQLLQQQQAQLQQQLLEQQQAQLQQQL 278
Query: 556 LMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP 591
L+ QQ LQQ+ QQ Q Q P EP
Sbjct: 279 LLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEP 314
Score = 68.6 bits (166), Expect = 3e-11
Identities = 70/229 (30%), Positives = 98/229 (42%), Gaps = 18/229 (7%)
Query: 358 PTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ 417
P TET + Q + G PG + + + P + S +P + A V
Sbjct: 20 PATETFVLELQCLEDG----GPGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGA 75
Query: 418 PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPA---QAQATPQH--QQQLFLKQQ 472
+ + Q +Q + P PQQ P + P + Q PQ QQQL QQ
Sbjct: 76 SEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQ 135
Query: 473 QQQQQPPPAQQQPA-GTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF 531
++ Q + +P +QQQQ Q QQ Q QQ Q + +Q +QQ++Q
Sbjct: 136 EKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQ----QEQLQTQQAQEQQVLQQQ 191
Query: 532 --YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQ 578
QQQ Q+QQ QQQQ L QQQL+ QQ LQQ+ +Q Q Q
Sbjct: 192 EQLQQQVQEQQLLQQQQ--EQLQQQQLLQQQEQLQQQQFQQQQEQLQQQ 238
Score = 62.8 bits (151), Expect = 2e-09
Identities = 63/212 (29%), Positives = 93/212 (43%), Gaps = 14/212 (6%)
Query: 417 QPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQ 476
Q + Q Q L Q + QQ + Q L Q QA Q QQQL L+QQ+Q Q
Sbjct: 230 QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQA--QLQQQLLLQQQEQLQ 287
Query: 477 QPPPAQQQPAGTFYQQQQAQTQQFQA--VHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQ 534
Q QQQ QQ+Q Q QQ Q + P ++ + V G Q+ Q +
Sbjct: 288 Q----QQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELE 343
Query: 535 QQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQ 594
+QQ+ ++QQ+Q+ Q++L + L+Q+ Q+ Q + A QE ++
Sbjct: 344 RQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLE 403
Query: 595 -APVRQQPKVQTTPPPAVQGQKVGSLTPPSSP 625
PV QP++Q PA G G P +P
Sbjct: 404 LTPV--QPELQLELVPAAGG---GGAAVPGAP 430
Score = 58.5 bits (140), Expect = 3e-08
Identities = 60/194 (30%), Positives = 82/194 (42%), Gaps = 20/194 (10%)
Query: 414 SVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQ 473
S + +PQ S P + A ++T Q + Q + P+ QQQ Q +
Sbjct: 51 SQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQ---PQHE 107
Query: 474 QQQQPPP---AQQQPAGTFYQQ-QQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQ 529
Q QQP P QQQP QQ Q Q ++ Q+VH +P + QQQL
Sbjct: 108 QLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMH------QQQQLQP 161
Query: 530 NFYQQQQ---QQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPA 586
Q+QQ QQQ+Q Q QQ +QQ++ QQ LQQ+ Q Q + Q
Sbjct: 162 QQVQEQQRLQQQQEQLQTQQ----AQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLL 217
Query: 587 PAQEPAIQAPVRQQ 600
QE Q +QQ
Sbjct: 218 QQQEQLQQQQFQQQ 231
Score = 58.2 bits (139), Expect = 4e-08
Identities = 76/268 (28%), Positives = 99/268 (36%), Gaps = 37/268 (13%)
Query: 421 QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQ-----QQ 475
Q Q L Q Q Q Q QQ Q Q L Q + Q QQQ L+QQQ QQ
Sbjct: 247 QGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ 306
Query: 476 QQPPPAQQQ----------PAGTFYQQQ-QAQTQQFQAVHPATQQPAIAQFPVVSQGGSQ 524
QPPP + + P +Q+ + Q Q+ + +Q Q + Q Q
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366
Query: 525 QQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQ--------QAALQQKPTMAAGQQPQ 576
Q Q QQQQ +QQ+ Q + L QQ Q + L+ P G
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVPAAGGGGAAV 426
Query: 577 PQPAAAPQPAPAQEPAIQ----APVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGH 632
P AA AP +Q P P V P PA +LTP + +RA
Sbjct: 427 PGAPAAVVVAPPGYVVVQELMVLPAVAAPAVVAIPGPAGS----AALTPARQRRRRRARD 482
Query: 633 RRILSDVTHSAVFGVPASKSTQLLQAAA 660
R T G S+ST L++ A
Sbjct: 483 R-----PTICGECGKGFSRSTDLVRHQA 505
Score = 52.8 bits (125), Expect = 2e-06
Identities = 58/195 (29%), Positives = 83/195 (42%), Gaps = 13/195 (6%)
Query: 416 PQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQ-GLPAQAQATPQHQQQLFLKQQQQ 474
P P + S + ++PQ + Q P+ A G A+ T Q++L L+Q +Q
Sbjct: 37 PGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQ 96
Query: 475 QQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQ 534
Q +P QQQP QQ Q + Q QQ ++Q Q ++ Q
Sbjct: 97 QPEP---QQQPQHEQLQQPQPHLELQQQPQQDGQQQ-LSQLQQEKHQSVHHQELKPELQL 152
Query: 535 QQQQQQ---QQQQQQLATALHQQQLMTQQAALQQ--KPTMAAGQQPQPQPAAAPQPAPAQ 589
QQQQ QQ Q+Q Q+QL TQQA QQ + QQ Q Q Q Q
Sbjct: 153 MHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQ 212
Query: 590 EPAIQAPVRQQPKVQ 604
+ Q ++QQ ++Q
Sbjct: 213 Q---QQLLQQQEQLQ 224
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 89.7 bits (221), Expect = 1e-17
Identities = 106/426 (24%), Positives = 186/426 (43%), Gaps = 57/426 (13%)
Query: 72 ALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRG 131
++++ + +E D+ +REI+IM L+ H +I+ + N +++I+M++
Sbjct: 85 SIRKDKIKDEQDMVHIRREIEIMSSLN-HPHIISIYEVFENKD------KIVIIMEYASK 137
Query: 132 GQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYV 191
G++ + +++R + +E E F AV H K ++HRDLK+ENILL D +
Sbjct: 138 GELYDYISERRR--LSERETRHFFRQIVSAVHYCH--KNGVVHRDLKLENILLDDNCNIK 193
Query: 192 LCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLS--YRAPEMVN--LYSGKIITTKADIWA 247
+ DFG +N +Q +D+ + S Y +PE+VN Y G + D WA
Sbjct: 194 IADFG-LSNLYQ----------KDKFLQTFCGSPLYASPEIVNGRPYRG----PEVDSWA 238
Query: 248 LGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRP 302
LG LLY L Y T+PF I G + P D LIR+ML +PD+R
Sbjct: 239 LGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ---PSDARGLIRWMLMVNPDRRA 295
Query: 303 DIYQVS-----YFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPI 357
I ++ + +K +C + SP+ A++ + S T+ K +
Sbjct: 296 TIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAK- 354
Query: 358 PTTETSIAPRQRPKAGQTQPNPGILPIQPAL--TPRKRATVQPP------PQAAGSSNQP 409
PTT + RQR + N Q A+ +P K ++ +P + S+
Sbjct: 355 PTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHST 414
Query: 410 GLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFL 469
G + V P P + + Q + P+ +P + G + Q+ ++ +
Sbjct: 415 GFIEGV--VGPALPSTFKMEQDLCRTGVLLPS---SPEAEVPGKLSPKQSATMPKKGILK 469
Query: 470 KQQQQQ 475
K QQ++
Sbjct: 470 KTQQRE 475
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 88.6 bits (218), Expect = 3e-17
Identities = 103/413 (24%), Positives = 171/413 (41%), Gaps = 84/413 (20%)
Query: 51 VLAEGGFAIVFL-VRTSNGMKCALKRMFVNN--EHDLQVCKREIQIMRDLSGHKNIVGYI 107
V+ G F IV L +R ++ +K++ V + + Q + E Q+++ L H N++ Y
Sbjct: 9 VVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLK-LLNHPNVIEYY 67
Query: 108 DSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQ 167
++ + + + ++I M++ GG + + +R + E +L F A+ +H
Sbjct: 68 ENFLEDKA------LMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHT 121
Query: 168 CKTPIIHRDLKVENILLHDRGHYV-LCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLS-- 224
I+HRDLK +NILL V + DFG + + + K YT +
Sbjct: 122 HL--ILHRDLKTQNILLDKHRMVVKIGDFGIS------------KILSSKSKAYTVVGTP 167
Query: 225 -YRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPD 278
Y +PE L GK K+DIWALGC+LY+L F + + I G F P
Sbjct: 168 CYISPE---LCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFA-PI 223
Query: 279 NSRYSQDMHCLIRYMLEPDPDKRPDIYQV---------------SYFSFKLLKKECPIP- 322
+ RYS ++ L+ +L +P +RP + + S ++ + E +
Sbjct: 224 SDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAP 283
Query: 323 -------------NVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTE-TSIAPRQ 368
+ P+ +P P+ + A RL P+ TE +A +
Sbjct: 284 SNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRL--PMLNTEVVQVAAGR 341
Query: 369 RPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQ 421
KAG T+ IL PP A G S PG +V QP+PQ
Sbjct: 342 TQKAGVTRSGRLIL------------WEAPPLGAGGGSLLPG---AVEQPQPQ 379
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 87.4 bits (215), Expect = 6e-17
Identities = 157/721 (21%), Positives = 276/721 (38%), Gaps = 86/721 (11%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G ++ ++M+FC G + +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLH-- 145
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
+IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++D+W+ G + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + +FSF + C + N P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFFSF---IEGCLVKNYMQRPSTEQLLKHPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + + + + P Q
Sbjct: 294 NER-QVRIQLKDHI--------DRTRKKRGEKDET------EYEYSGSEEEEEEVPEQ-- 336
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQ- 462
+P + +VP L Q ++ +A Q Q Q L Q + Q
Sbjct: 337 --EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ---LLQEQQLREQEEYKRQL 391
Query: 463 -HQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQG 521
++Q ++QQ++Q++ QQ+ +QQ+ + ++ + + + +
Sbjct: 392 LAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Query: 522 GSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAA 581
++ + ++Q+ ++Q +++Q + QQQL+ +QA L + ++P PQ +
Sbjct: 452 RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAML-----LHDHRRPHPQHSQ 506
Query: 582 APQPAPAQE---PAIQAPVRQQPKVQTTPPP-AVQGQKVGSLTPPSSPKTQRAGHRRILS 637
P P P QE P+ AP +PK P A + + T SSP+ Q R+L
Sbjct: 507 QP-PPPQQERSKPSFHAP---EPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLE 562
Query: 638 DVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNP 697
S S + A A + + T S SP S+++ G +
Sbjct: 563 PPVPSRSESFSNGNSESVHPALQRPA---EPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQ 619
Query: 698 FDDDNFSKLTAEELLNKDFAKL----GEGKHP-EKLGGSAESLIPGFQSTQGDAFATTSF 752
N + LL + KL G G GS PG QS G+ F S
Sbjct: 620 AGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSS 679
Query: 753 S 753
S
Sbjct: 680 S 680
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 87.0 bits (214), Expect = 7e-17
Identities = 92/276 (33%), Positives = 118/276 (42%), Gaps = 47/276 (17%)
Query: 403 AGSSNQPGLLASVPQPKPQAPP----SQPLPQTQAKQPQAPP--------TPQQTPST-Q 449
AG S Q G L + Q KPQ + P P + +Q P QQ PS
Sbjct: 517 AGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLP 576
Query: 450 AQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQ 509
+Q P+ T Q QQQ +QQQQQQQ QQQ QQQQ Q QQ ++ QQ
Sbjct: 577 SQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQ------QQQQQQQQQQSSISAQQQQ 630
Query: 510 PAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQL-----ATALHQQQLMTQQAALQ 564
Q +S QQQ Q QQQQQQQQQQQQQQ A +L Q L+ LQ
Sbjct: 631 Q---QQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQ 687
Query: 565 QKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVG---SLTP 621
QK + QQ Q QP A +Q+ Q +V GQ G S P
Sbjct: 688 QKLLL---QQMQNQPIAGMGYQVSQQ-------------QRQDQHSVVGQNTGPSPSPNP 731
Query: 622 PSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQ 657
S+P T +G+ + + + G + Q+++
Sbjct: 732 CSNPNT-GSGYMNSQQSLLNQQLMGKKQTLQRQIME 766
Score = 68.6 bits (166), Expect = 3e-11
Identities = 97/359 (27%), Positives = 135/359 (37%), Gaps = 59/359 (16%)
Query: 366 PRQRPKAGQTQPNPGILPIQPALTP----RKRATVQPPPQAAGSSNQPGLLASVPQPKPQ 421
P+ ++ P+P + P Q P Q P S N+P LL Q + Q
Sbjct: 534 PQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQ 593
Query: 422 APPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFL-----KQQQQQQ 476
Q Q Q +Q Q QQ Q Q + A Q QQQ + +QQQQQQ
Sbjct: 594 QQQQQQQQQQQQQQQQ-----QQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQ 648
Query: 477 QPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPA--IAQFPVVSQGGSQQQLMQN---- 530
Q QQ QQQQ Q QQ + PA P+ + + P+ Q Q MQN
Sbjct: 649 QQQQQQQ-------QQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIA 701
Query: 531 --FYQQQQQQQQQQQQ---QQLATA---------------LHQQQLMTQQAALQQKPTMA 570
YQ QQQ+Q Q Q + ++ QQ + Q + +K T+
Sbjct: 702 GMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQ 761
Query: 571 AGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQK--VGSLTPPSSPKTQ 628
Q Q Q A I AP Q + + PPP + Q+ VG++ P Q
Sbjct: 762 RQIMEQKQQLLLQQQMLADAEKI-APQDQINRHLSRPPPDYKDQRRNVGNM----QPTAQ 816
Query: 629 RAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY 687
+G +S ++ A+ P S T L +SL + T PS S +Y
Sbjct: 817 YSGGSSTISLNSNQALAN-PVSTHTIL----TPNSSLLSTSHGTRMPSLSTAVQNMGMY 870
Score = 55.1 bits (131), Expect = 3e-07
Identities = 88/389 (22%), Positives = 131/389 (33%), Gaps = 94/389 (24%)
Query: 386 PALTPRKRATVQ-PPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQ 444
P LT + Q PP A + + S P P P SQ PQT + +A P+ Q+
Sbjct: 370 PGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQE 429
Query: 445 TPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPP-----PAQQQPAGTFYQQQQAQTQQ 499
+ AQ L Q QQ ++Q QQQ QP P+ P+ + Q++ +
Sbjct: 430 V--SHAQQL---KQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPS 484
Query: 500 FQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF---------------YQQQQQQ------ 538
F T P + P V+ G Q ++M N+ QQ+ Q
Sbjct: 485 F---GQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSF 541
Query: 539 ---------------------QQQQQQQQLATAL-------------------HQQQLMT 558
Q QQ+ + L QQQ
Sbjct: 542 INNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQ 601
Query: 559 QQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQA-PVRQQPKVQTTPPPAVQGQKVG 617
QQ QQ+ QQ Q Q + + Q Q+ +I A +QQ + Q Q Q+
Sbjct: 602 QQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQ 661
Query: 618 SLTPPSSPKTQR------------AGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASL 665
PSS Q + +L + + + G+ S Q Q +
Sbjct: 662 QQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQ 721
Query: 666 NKSKSATTTPSGSPRT------SQQNVYN 688
N S + P +P T SQQ++ N
Sbjct: 722 NTGPSPSPNPCSNPNTGSGYMNSQQSLLN 750
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 86.7 bits (213), Expect = 1e-16
Identities = 88/272 (32%), Positives = 108/272 (39%), Gaps = 46/272 (16%)
Query: 374 QTQPNPGILPIQPALTPRKRATVQP--------------PPQAAGSSNQPGLLASVPQPK 419
Q Q PG+ Q AL P+ + + P PPQ P +A + Q
Sbjct: 3756 QQQQGPGVQTNQ-ALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQH 3814
Query: 420 PQA-PPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQ- 477
P A P P Q Q + +PQ + Q QGL T Q QQQ QQQ QQQ
Sbjct: 3815 PGALGPQGPHRQVLMTQSRVLSSPQL--AQQGQGLMGHRLVTAQQQQQ----QQQHQQQG 3868
Query: 478 -----------------PPPAQQQPAGTFYQ-QQQAQTQQFQAVHPATQQPAIAQFPVVS 519
P QP G+ Q QQQ Q QQ Q + QQ Q
Sbjct: 3869 SMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQ----- 3923
Query: 520 QGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQP 579
Q QQQL Q QQQ QQQQQQQ QQ L QQQ QQ QQ+ G Q +
Sbjct: 3924 QQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRT 3983
Query: 580 AAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAV 611
+PQ Q+ A+ + +P + P A+
Sbjct: 3984 LLSPQQQQQQQVALGPGMPAKPLQHFSSPGAL 4015
Score = 61.2 bits (147), Expect = 4e-09
Identities = 82/312 (26%), Positives = 118/312 (37%), Gaps = 33/312 (10%)
Query: 391 RKRATVQPPPQAAGSSNQPGLLASVPQPKPQAP---PSQPLPQTQAKQPQAPPTPQQ--- 444
R + Q Q +LA P P+ P Q LP + PQ PP Q
Sbjct: 3596 RNKQQQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGL 3655
Query: 445 --TPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQA 502
TP A LP Q P L +QQQQ + P+G F+ A ++
Sbjct: 3656 RLTPGGMA--LPGQPGG-PFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLA----LRS 3708
Query: 503 VHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAA 562
+ P ++ Q + QQQ MQ + QQQQQQQQQQQ L + QQ Q
Sbjct: 3709 LGPDSRLLQERQLQL------QQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPG 3762
Query: 563 LQQKPTMAAGQQPQP-QPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTP 621
+Q A G +PQ P ++ Q Q+ + Q P Q + +Q Q G+L P
Sbjct: 3763 VQ--TNQALGPKPQGLMPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQHPGALGP 3820
Query: 622 PSSPKTQRAGHRRILSD---------VTHSAVFGVPASKSTQLLQAAAAEASLNKSKSAT 672
+ R+LS + + + Q Q + A L+ + +
Sbjct: 3821 QGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQQSL 3880
Query: 673 TTPSGSPRTSQQ 684
+ SG P+ S Q
Sbjct: 3881 MSHSGQPKLSAQ 3892
Score = 56.2 bits (134), Expect = 1e-07
Identities = 156/676 (23%), Positives = 228/676 (33%), Gaps = 163/676 (24%)
Query: 361 ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAG----SSNQPGLLASVP 416
+ ++ P K Q +PG L LT +++ TV P + S++Q G LA
Sbjct: 3994 QVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGPSTHQGGPLAIGT 4053
Query: 417 QPKPQAP------PS----------QPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQAT 460
P+ A PS QP PQ Q Q P P + P Q Q + A
Sbjct: 4054 TPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQP-PLRLPGQQQQQVSLLHTAG 4112
Query: 461 PQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVH---------------- 504
QL + P QP+ + Q + TQ
Sbjct: 4113 GGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQP 4172
Query: 505 ----PATQQ----PAIAQFPVVSQGGSQQQ--LMQNFYQQQQQQQQQQQQQQLATALHQQ 554
P Q P + P V Q +Q Q L +N Q + QQQQQL L Q+
Sbjct: 4173 PKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKN---PQLRHLSPQQQQQLQALLMQR 4229
Query: 555 QLMTQQAALQQKPTMAAGQQPQP-------QPA----AAPQPAPAQEPAIQAPVRQQPKV 603
QL QA Q P G Q P QP PQ P QE + P++
Sbjct: 4230 QLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRL 4289
Query: 604 QTTPPPAVQGQKVGSL---TPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA 660
P G +G + PPSSP+ + + S S+QL
Sbjct: 4290 PAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQL--------------PSPSSQL----P 4331
Query: 661 AEASLNKSKSATTTPSG----------SPRTSQQNVYNPSEG-STWNPFDDDNFSKLTAE 709
EA L + T P G SP +Q S+G W+P D+
Sbjct: 4332 TEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDN--------- 4382
Query: 710 ELLNKDFAKLGEGKHPEKLGGSAESLIPG-FQSTQGDAFATTSFSAGTAEKRKGGQTVDS 768
L E + PE+ SL+PG G S + E R+ +
Sbjct: 4383 ---------LAETQKPEQ-----SSLVPGHLDQVNGQVVPEASQLSIKQEPRE--EPCAL 4426
Query: 769 GLPLLSVSDPFIPLQVPDAPEK-LIEGLKSPDTSLLLPDLLPMTD---PFGSTSDAVIEK 824
G + P+ P L+ G +S LLL LL + G S+ + +
Sbjct: 4427 GAQSVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGRGSEGLRAE 4486
Query: 825 ADVAVESLIPGLE-------------------PPVPQRLPSQTESVTSNR-----TDSLT 860
+ ++S + GLE P P+R+ ++ + S+R D +
Sbjct: 4487 INGHIDSKLAGLEQKLQGTPSNKEDAAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVR 4546
Query: 861 GEDSLL-----DCSL--LSNPT-TDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDK 912
++LL + SL L+ P T FAP PV+ ++ +P G D
Sbjct: 4547 ASEALLKQLKQELSLLPLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDY 4606
Query: 913 VAEDEFDPIPVLITKN 928
++ L+TKN
Sbjct: 4607 YSQ--------LLTKN 4614
Score = 53.5 bits (127), Expect = 9e-07
Identities = 92/392 (23%), Positives = 138/392 (35%), Gaps = 38/392 (9%)
Query: 320 PIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNP 379
P+ + P A EP AS K + + P P T P+ P
Sbjct: 3093 PLGPEERPPPAADASEPRLASVLPEVKPKVEEGGRHPSPCQFTIATPKVEPAPAANSLGL 3152
Query: 380 GILPIQPALTPRKRATVQPPPQAAGSSNQP-------GLLASVPQPKPQAPP--SQPLPQ 430
G+ P Q + R P ++G + + G A + P P + P S L +
Sbjct: 3153 GLKPGQSMMGSRDTRMGTGPFSSSGHTAEKASFGATGGPPAHLLTPSPLSGPGGSSLLEK 3212
Query: 431 TQAKQ-----PQAPPTP-----QQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP 480
+ + P P + S A LP + +H+++ K+QQ Q P
Sbjct: 3213 FELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQP 3272
Query: 481 AQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQ--Q 538
AQQQ QQQQ Q A PA + S GSQQQL +Q
Sbjct: 3273 AQQQ------QQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQLSLGLAGARQPGLP 3326
Query: 539 QQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQ---QPQPQPAAAPQPAPAQEPAIQA 595
Q Q A AL QQ+L A + + M +GQ Q P + QP +Q+P
Sbjct: 3327 QPLMPTQPPAHAL-QQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQSSQPVLSQKPMGTM 3385
Query: 596 PVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQL 655
P K Q A+Q Q S P + + I+ + + + + K
Sbjct: 3386 PPSMCMKPQQL---AMQQQLANSFFPDTD--LDKFAAEDIIDPIAKAKMVALKGIKKVMA 3440
Query: 656 LQAAAAEASLNKSKSATTTP--SGSPRTSQQN 685
+ +N+ + + SG P + QN
Sbjct: 3441 QGSIGVAPGMNRQQVSLLAQRLSGGPSSDLQN 3472
Score = 50.4 bits (119), Expect = 8e-06
Identities = 138/658 (20%), Positives = 219/658 (33%), Gaps = 118/658 (17%)
Query: 320 PIPNVQN-SPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPN 378
P+P V SP P + P E+ +RL+ P + TS P P + + +
Sbjct: 655 PLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDS 714
Query: 379 PGILPIQPA-LTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAP-----PSQPLPQTQ 432
LP++ + L P + PQ S P L P+P+ P P +P Q
Sbjct: 715 LMSLPLEESPLLP-----LPEEPQLCPRSEGPHL-----SPRPEEPHLSPRPEEPHLSPQ 764
Query: 433 AKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQ 492
A++P P P++ P A +P + +PQ + L Q ++ P ++P
Sbjct: 765 AEEPHLSPQPEE-PCLCA--VPEEPHLSPQAEGP-HLSPQPEELHLSPQTEEP------- 813
Query: 493 QQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALH 552
+ P ++P ++ P S Q ++ + ++ L+ L
Sbjct: 814 ---------HLSPVPEEPCLSPQPEESHLSPQ--------SEEPCLSPRPEESHLSPELE 856
Query: 553 QQQLMTQQAALQQKPTMAAGQQPQPQ--PAAAPQPAPAQEPAIQAPVRQQPKVQTTPP-- 608
+ L + +KP GQ P P+ P P P+ P + P +P P
Sbjct: 857 KPPLSPR----PEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLP 912
Query: 609 ----------PAVQGQKV--GSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQL- 655
P++ Q + L PP SP A + FG +
Sbjct: 913 EELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESP 972
Query: 656 LQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKD 715
L A E ++ A T P + PS GS P L +
Sbjct: 973 LAAPILETPISPPPEANCT---DPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQ 1029
Query: 716 FAKLGEGKHPEKLGGSAESL-IPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLS 774
+ + + P + A L +P S G + AE + +
Sbjct: 1030 HSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSD----EAELHE--------METEK 1077
Query: 775 VSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIP 834
VS+P P P A L + D S P P D F + D A +
Sbjct: 1078 VSEPECPALEPSATSPLPSPM--GDLSCPAPSPAPALDDFSGLGE------DTAP---LD 1126
Query: 835 GLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLS------------------NPTT 876
G++ P Q P QT + L G LLD L+ +P
Sbjct: 1127 GIDAPGSQPEPGQT---PGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPCE 1183
Query: 877 DLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHS 934
+ E AP A + P ++ N IS + S E P+L + +P+GG S
Sbjct: 1184 EQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSE----PLLGSPDPEGGGS 1237
Score = 44.3 bits (103), Expect = 6e-04
Identities = 50/183 (27%), Positives = 69/183 (37%), Gaps = 29/183 (15%)
Query: 432 QAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQ------- 484
Q + P P+ P T AQG+ +A Q+++ LF QQ Q Q ++Q
Sbjct: 3480 QERSAGDPSQPRPNPPTFAQGVINEADQR-QYEEWLFHTQQLLQMQLKVLEEQIGVHRKS 3538
Query: 485 ------------PAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFY 532
AG + + A+ + + Q + Q V Q LM +
Sbjct: 3539 RKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQ--VRKQQKEHTNLMAEYR 3596
Query: 533 QQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPA 592
+QQQQQQQQQQQQ QQ + Q P + Q P QP P P
Sbjct: 3597 NKQQQQQQQQQQQQ------QQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQP-PQGPPG 3649
Query: 593 IQA 595
QA
Sbjct: 3650 GQA 3652
Score = 40.4 bits (93), Expect = 0.008
Identities = 59/318 (18%), Positives = 114/318 (35%), Gaps = 35/318 (11%)
Query: 294 LEPDPDKRPDIYQVSYFSFKLLKKECPI-PNVQNSPI---PAKLP-EPVKASEAAAKKTQ 348
L P P++ P +E P+ P + SP+ P P P++ S + +
Sbjct: 467 LSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES 526
Query: 349 PKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQ 408
P P P ET ++P P P+ P P + + + PPP+ +S
Sbjct: 527 P------PSPALETPLSPP-----------PEASPLSP---PFEESPLSPPPEELPTSPP 566
Query: 409 P--GLLASVPQPKPQAPPSQPLPQTQAKQPQA--PPTPQQTPSTQAQGLPAQAQATPQHQ 464
P L+ P+ P +PP + P + + PP + S + P + P
Sbjct: 567 PEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPL---SPPPEA 623
Query: 465 QQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQ 524
+L + PPP + + + + + P ++ ++ P S
Sbjct: 624 SRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPP 683
Query: 525 QQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQP-AAAP 583
+ + + + A+ + LM+ L++ P + ++PQ P + P
Sbjct: 684 PEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMS--LPLEESPLLPLPEEPQLCPRSEGP 741
Query: 584 QPAPAQEPAIQAPVRQQP 601
+P E +P ++P
Sbjct: 742 HLSPRPEEPHLSPRPEEP 759
Score = 39.3 bits (90), Expect = 0.018
Identities = 74/362 (20%), Positives = 119/362 (32%), Gaps = 29/362 (8%)
Query: 358 PTTETS---IAPRQRPKAGQT---QPN-PGILPIQPALTPRKRATVQPPPQAAGSSNQPG 410
PT E +A + +PK G QP PG P+Q P +A VQ PQ N+
Sbjct: 381 PTDEPDALYVACQGQPKGGHVTSMQPKEPG--PLQCEAKPLGKAGVQLEPQLEAPLNEEM 438
Query: 411 LLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLK 470
L P+ P +PP + + P +PP S + LPA H L
Sbjct: 439 PLLPPPEESPLSPPPE-------ESPTSPPPEASRLSPPPEELPASPLPEALH---LSRP 488
Query: 471 QQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQN 530
++ PPP + + + ++ P P+ A +S L
Sbjct: 489 LEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPP 548
Query: 531 FYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAP--QPAPA 588
F + ++ + +++ + P + P P + +P
Sbjct: 549 FEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPL 608
Query: 589 QEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVP 648
P ++P+ P+ PP S P SP + R LS + + P
Sbjct: 609 SPPPEESPLSPPPEASRLSPPPEDSPM--SPPPEESPMSPPPEVSR-LSPLPVVSRLSPP 665
Query: 649 ASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTA 708
+S + S S + P TS P E S +P +D+ L
Sbjct: 666 PEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSP-----PPEDSPASPPPEDSLMSLPL 720
Query: 709 EE 710
EE
Sbjct: 721 EE 722
Score = 38.1 bits (87), Expect = 0.040
Identities = 49/190 (25%), Positives = 74/190 (38%), Gaps = 30/190 (15%)
Query: 524 QQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAP 583
+QQL Q QQQQQQQQQ L +A Q M+ P++A QQ A
Sbjct: 3263 KQQLSAQL-QPAQQQQQQQQQHSLLSAPGPAQAMSLPHE-GSSPSLAGSQQQLSLGLAG- 3319
Query: 584 QPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSA 643
A++P + QP + T PP Q++ PS GH + H
Sbjct: 3320 ----ARQPGL-----PQPLMPTQPPAHALQQRLA----PSMAMVSNQGH---MLSGQHGG 3363
Query: 644 VFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNF 703
G+ +S+Q + L++ T PS + Q + S F D +
Sbjct: 3364 QAGLVPQQSSQPV--------LSQKPMGTMPPSMCMKPQQLAMQQQLANSF---FPDTDL 3412
Query: 704 SKLTAEELLN 713
K AE++++
Sbjct: 3413 DKFAAEDIID 3422
Score = 37.4 bits (85), Expect = 0.068
Identities = 90/400 (22%), Positives = 128/400 (32%), Gaps = 68/400 (17%)
Query: 322 PNVQNSPIP-AKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPG 380
P+V P P LP + + T P + DP +S+A + P +PG
Sbjct: 2613 PSVLPPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAELPGT----QDPG 2668
Query: 381 ILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPP 440
+ + ++R + Q L + A + P + +P +P
Sbjct: 2669 MSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPA 2728
Query: 441 TPQ----QTPSTQAQ------GLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFY 490
Q QTP Q GLP + P F + + PPPA
Sbjct: 2729 FEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNS 2788
Query: 491 QQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATA 550
+Q +Q F + P P+ QQQQQQ QQQQ AT+
Sbjct: 2789 RQLVGGSQAFYQ-----RAPYPGSLPL---------------QQQQQQLWQQQQATAATS 2828
Query: 551 LHQQQLMTQQAALQQKPTMAAGQQPQPQPAA------------APQPA-PAQEPAIQAPV 597
+ A P G+Q P A P PA PAQ ++ V
Sbjct: 2829 MR----FAMSARFPSTPGPELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNV 2884
Query: 598 RQQPKVQTTPPPAVQGQKVGSLTPPSSPK---TQRAGHRRILSDVTHSAVFGVPASKSTQ 654
++ TP P QG PP P+ HR + AV G+P K
Sbjct: 2885 QKGLGPGGTPFPG-QG-------PPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQK--- 2933
Query: 655 LLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGST 694
+A LN S T G + + N ST
Sbjct: 2934 --PSAPPAPELNNSLHPTPHTKGPTLPTGLELVNRPPSST 2971
Score = 36.2 bits (82), Expect = 0.15
Identities = 76/351 (21%), Positives = 121/351 (34%), Gaps = 81/351 (23%)
Query: 385 QPALTPRKRATVQPPPQAAGSSNQPGLLASVPQP--------------KPQAPPSQPLPQ 430
+P+L P PPP S PG PQ P P S +
Sbjct: 2544 EPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGE 2603
Query: 431 TQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFY 490
+ P PP+ P+ LP + Q+ P +++ GT
Sbjct: 2604 SYGLSPLRPPSVLPPPAPDG-SLPYLSHGA----------SQRSGITSPVEKREDPGTGM 2652
Query: 491 QQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATA 550
A + P TQ P ++ G SQ +L ++Q+Q+Q+L
Sbjct: 2653 GSSLATAEL-----PGTQDPGMS-------GLSQTEL-----------EKQRQRQRLREL 2689
Query: 551 LHQQQLMTQQAALQQKPT--MAAGQQPQPQPAAAPQPAPAQEPAIQ-----APVRQQPKV 603
L +QQ+ + Q+K T AAG P A +PA E + A + + +
Sbjct: 2690 LIRQQIQ-RNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSL 2748
Query: 604 QTTPPPAVQGQKVGSLT-----------PPSSPKTQRAGHRRILSDVTHSAVF------- 645
PP + G +G + PP++P + R++ V S F
Sbjct: 2749 VGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQL---VGGSQAFYQRAPYP 2805
Query: 646 -GVPASKSTQLL---QAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEG 692
+P + Q L Q A A S+ + SA + P +Q + +P G
Sbjct: 2806 GSLPLQQQQQQLWQQQQATAATSMRFAMSARFPSTPGPELGRQALGSPLAG 2856
Score = 35.0 bits (79), Expect = 0.34
Identities = 26/99 (26%), Positives = 37/99 (37%), Gaps = 7/99 (7%)
Query: 370 PKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQA-PPSQPL 428
P+A Q +P L ++P P +A PP + P + P A PP P
Sbjct: 2333 PRASQVEPQSPGLGLRPQEPPPAQALAPSPP------SHPDIFRPGSYTDPYAQPPLTPR 2386
Query: 429 PQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQL 467
PQ + P+ PS +PA Q+ Q L
Sbjct: 2387 PQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPL 2425
Score = 33.5 bits (75), Expect = 0.98
Identities = 25/102 (24%), Positives = 39/102 (38%), Gaps = 13/102 (12%)
Query: 387 ALTPRKRATVQPPPQAAGSSNQPGL---LASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQ 443
+L ++ +PP Q + + N L S P P+ +PP PL P+P
Sbjct: 4877 SLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPL----------APSPA 4926
Query: 444 QTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQP 485
P+ LP + A P L L + +P P + P
Sbjct: 4927 SPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPP 4968
Score = 33.1 bits (74), Expect = 1.3
Identities = 30/99 (30%), Positives = 37/99 (37%), Gaps = 12/99 (12%)
Query: 358 PTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ 417
P E PR + P PG L P L P V P P + S +P + +P
Sbjct: 4273 PLQELGAGPRPQGPPRLPAP-PGALSTGPVLGP-----VHPTPPPS-SPQEPKRPSQLPS 4325
Query: 418 PKPQAPPSQPLPQTQ--AKQPQAP---PTPQQTPSTQAQ 451
P Q P LP T +PQ P P P + AQ
Sbjct: 4326 PSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQ 4364
Score = 32.7 bits (73), Expect = 1.7
Identities = 72/339 (21%), Positives = 102/339 (30%), Gaps = 59/339 (17%)
Query: 320 PIPNVQNSPIPAKLPE--------PVKASEAAAKKTQPKA--------------RLTDPI 357
P P SP PA P P S +A +P A +L +
Sbjct: 2108 PQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQV 2167
Query: 358 PTTETSIAPRQRPKAGQTQPN-PGILPIQPALTPRKRATVQPPPQAAGS---SNQPGLLA 413
P S P A +P P P P A QPP A S + QPG
Sbjct: 2168 PAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFH 2227
Query: 414 SVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQ 473
+ P P+ PS P P + + P A P+ K +
Sbjct: 2228 TTPPGTPRHQPSTPDPFLKPRCPS-----------------LDNLAVPESPGVGGGKASE 2270
Query: 474 QQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQ----GGSQQQLMQ 529
PP P G + + + ++ A P+ P + S GG + +
Sbjct: 2271 PLLSPP-----PFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPD 2325
Query: 530 NFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPT------MAAGQQPQPQPAAAP 583
F + Q + Q L Q+ QA P+ + P QP P
Sbjct: 2326 VFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTP 2385
Query: 584 QP-APAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTP 621
+P P E P R P + PA + S +P
Sbjct: 2386 RPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSP 2424
Score = 31.6 bits (70), Expect = 3.7
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 13/82 (15%)
Query: 398 PPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQA 457
PPP+ S P LA P P +PP++PL + + PP P P + P A
Sbjct: 4909 PPPEEP--SPPPSPLA----PSPASPPTEPLVELPTEPLAEPPVPSPLPLASS---PESA 4959
Query: 458 QATPQHQQQLFLKQQQQQQQPP 479
+ P+ + ++ + +PP
Sbjct: 4960 RPKPRARP----PEEGEDSRPP 4977
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 85.5 bits (210), Expect = 2e-16
Identities = 133/608 (21%), Positives = 245/608 (40%), Gaps = 79/608 (12%)
Query: 50 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYID 108
EV+ G + V+ R G A+K M V + + ++ K EI +++ S H+NI Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEI-KLEINMLKKYSHHRNIATYYG 87
Query: 109 SSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQC 168
+ I G ++ ++M+FC G + +L+ E+ + I + +A LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLH-- 145
Query: 169 KTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLSY 225
+IHRD+K +N+LL + L DFG + Q +T G ++ T T +
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSA---QLDRTVG--------RRNTFIGTPYW 194
Query: 226 RAPEMVNLYSGKIIT--TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYS 283
APE++ T ++D+W+ G + E +CD
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGIT-------AIEMAEGAPPLCD-----------M 236
Query: 284 QDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAA 343
M L P P + + +FSF + C + N P +L + +
Sbjct: 237 HPMRALFLIPRNPPPRLKSKKWSKKFFSF---IEGCLVKNYMQRPSTEQLLKHPFIRDQP 293
Query: 344 AKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAA 403
++ Q + +L D I R R K G+ + + + + P Q
Sbjct: 294 NER-QVRIQLKDHI--------DRTRKKRGEKDET------EYEYSGSEEEEEEVPEQ-- 336
Query: 404 GSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQ- 462
+P + +VP L Q ++ +A Q Q Q L Q + Q
Sbjct: 337 --EGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQ---LLQEQQLREQEEYKRQL 391
Query: 463 -HQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQG 521
++Q ++QQ++Q++ QQ+ +QQ+ + ++ + + + +
Sbjct: 392 LAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Query: 522 GSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAAL---QQKPTMAAGQQPQP- 577
++ + ++Q+ ++Q +++Q + QQQL+ +QA L ++P QQP P
Sbjct: 452 RRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPP 511
Query: 578 -----QPA-AAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAG 631
+P+ AP+P EPA +A R+ P V+TT V ++ L S + +AG
Sbjct: 512 QQERSKPSFHAPEPKAHYEPADRA--REVP-VRTTSRSPVLSRRDSPL-QGSGQQNSQAG 567
Query: 632 HRRILSDV 639
R S +
Sbjct: 568 QRNSTSSI 575
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 85.1 bits (209), Expect = 3e-16
Identities = 80/268 (29%), Positives = 127/268 (47%), Gaps = 35/268 (13%)
Query: 50 EVLAEGGFAIVFLVRTSNGMKCALKRMF---VNNEHDLQVCKREIQIMRDLSGHKNIVGY 106
E L +G + V R S+G A+K + + +E DL +REI+IM L+ H +I+
Sbjct: 57 ETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN-HPHIIA- 114
Query: 107 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 166
I N S +++I+M++ G + + +++R Q +E E F AV H
Sbjct: 115 IHEVFENSS-----KIVIVMEYASRGDLYDYISERQQ--LSEREARHFFRQIVSAVHYCH 167
Query: 167 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYR 226
Q + ++HRDLK+ENILL G+ + DFG + Q + + Y
Sbjct: 168 QNR--VVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCG---------SPLYA 216
Query: 227 APEMVNLYSGKIIT-TKADIWALGCLLYKLCYFTLPFGESQ-----VAICDGNFTIPDNS 280
+PE+VN GK T + D W+LG LLY L + T+PF I +G + P
Sbjct: 217 SPEIVN---GKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPK- 272
Query: 281 RYSQDMHCLIRYMLEPDPDKRPDIYQVS 308
D LIR++L +P +R + V+
Sbjct: 273 --PSDACGLIRWLLMVNPTRRATLEDVA 298
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 84.3 bits (207), Expect = 5e-16
Identities = 84/319 (26%), Positives = 141/319 (44%), Gaps = 57/319 (17%)
Query: 51 VLAEGGFAIVFLVR-TSNGMKCALKRMFVNN--EHDLQVCKREIQIMRDLSGHKNIVGYI 107
V+ +G + V LV+ +G + +K++ + N + + ++E Q++ L H NIV Y
Sbjct: 11 VVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLK-HPNIVTYK 69
Query: 108 DSSINNVSSGDVWE-----VLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 162
+S WE + I+M FC GG + + ++ EN+V++ F A+
Sbjct: 70 ES----------WEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMAL 119
Query: 163 ARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTT 222
LH+ I+HRDLK +N+ L + D G A +E+ +T
Sbjct: 120 QYLHE--KHILHRDLKTQNVFLTRTNIIKVGDLGIA------------RVLENHCDMAST 165
Query: 223 LS----YRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQV-----AICDGN 273
L Y +PE L+S K K+D+WALGC +Y++ F + I +G
Sbjct: 166 LIGTPYYMSPE---LFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGK 222
Query: 274 FTIPDNSRYSQDMHCLIRYMLEPDPDKRPDI----------YQVSYFSFKLLKKECPIPN 323
P YS ++ LIR ML P++RP + Q+S+F + K + N
Sbjct: 223 LP-PMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISFF-LEATKIKTSKNN 280
Query: 324 VQNSPIPAKLPEPVKASEA 342
++N +K V + EA
Sbjct: 281 IKNGDSQSKPFATVVSGEA 299
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 84.0 bits (206), Expect = 6e-16
Identities = 88/318 (27%), Positives = 137/318 (43%), Gaps = 45/318 (14%)
Query: 10 EQGGSGLGSGSSGGGGSTSG----------LGSGYIGRVFGIGRQQVTVDEVLAEGGFAI 59
E+GGS G+ + G G + G +G + + +VL G +
Sbjct: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
Query: 60 VFLVRTSNG--------MKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSI 111
VFLVR +G MK K V + + E Q++ + +V
Sbjct: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTL----- 117
Query: 112 NNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTP 171
+ + ++ +++D+ GG++ ++QR + FTE+EV + A+ LH K
Sbjct: 118 -HYAFQTETKLHLILDYINGGELFTHLSQRER--FTEHEVQIYVGEIVLALEHLH--KLG 172
Query: 172 IIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMV 231
II+RD+K+ENILL GH VL DFG + +F +TE + T+ Y AP++V
Sbjct: 173 IIYRDIKLENILLDSNGHVVLTDFG-LSKEFVADETERAYSF------CGTIEYMAPDIV 225
Query: 232 NLYSGKIITTKA-DIWALGCLLYKLCYFTLPF---GESQVAICDGNFTIPDNSRYSQDMH 287
G KA D W+LG L+Y+L PF GE + Y Q+M
Sbjct: 226 R--GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 288 C----LIRYMLEPDPDKR 301
LI+ +L DP KR
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 84.0 bits (206), Expect = 6e-16
Identities = 88/318 (27%), Positives = 137/318 (43%), Gaps = 45/318 (14%)
Query: 10 EQGGSGLGSGSSGGGGSTSG----------LGSGYIGRVFGIGRQQVTVDEVLAEGGFAI 59
E+GGS G+ + G G + G +G + + +VL G +
Sbjct: 3 EEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGK 62
Query: 60 VFLVRTSNG--------MKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSI 111
VFLVR +G MK K V + + E Q++ + +V
Sbjct: 63 VFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTL----- 117
Query: 112 NNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTP 171
+ + ++ +++D+ GG++ ++QR + FTE+EV + A+ LH K
Sbjct: 118 -HYAFQTETKLHLILDYINGGELFTHLSQRER--FTEHEVQIYVGEIVLALEHLH--KLG 172
Query: 172 IIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMV 231
II+RD+K+ENILL GH VL DFG + +F +TE + T+ Y AP++V
Sbjct: 173 IIYRDIKLENILLDSNGHVVLTDFG-LSKEFVADETERAYSF------CGTIEYMAPDIV 225
Query: 232 NLYSGKIITTKA-DIWALGCLLYKLCYFTLPF---GESQVAICDGNFTIPDNSRYSQDMH 287
G KA D W+LG L+Y+L PF GE + Y Q+M
Sbjct: 226 R--GGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 283
Query: 288 C----LIRYMLEPDPDKR 301
LI+ +L DP KR
Sbjct: 284 ALAKDLIQRLLMKDPKKR 301
Score = 68.6 bits (166), Expect = 3e-11
Identities = 74/275 (26%), Positives = 119/275 (43%), Gaps = 50/275 (18%)
Query: 49 DEVLAEGGFAIV--FLVRTSN---GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNI 103
D+ L EG F+I + + SN +K KRM N + +EI ++ GH NI
Sbjct: 429 DKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ-------KEITALKLCEGHPNI 481
Query: 104 VGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVA 163
V ++ V D ++M+ GG++ + ++ F+E E I AV+
Sbjct: 482 V-----KLHEVFH-DQLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAVS 533
Query: 164 RLHQCKTPIIHRDLKVENILLHDRGHYV---LCDFGSATNKFQNPQTEGVNAVEDEIKKY 220
+H ++HRDLK EN+L D + + DFG A + + P + +
Sbjct: 534 HMHD--VGVVHRDLKPENLLFTDENDNLEIKIIDFGFA--RLKPPDNQPLKT------PC 583
Query: 221 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG------------ESQVA 268
TL Y APE++N D+W+LG +LY + +PF E
Sbjct: 584 FTLHYAAPELLNQNG---YDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKK 640
Query: 269 ICDGNFTIPDNS--RYSQDMHCLIRYMLEPDPDKR 301
I G+F+ + SQ+ LI+ +L DP+KR
Sbjct: 641 IKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKR 675
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/238 (29%), Positives = 116/238 (48%), Gaps = 29/238 (12%)
Query: 81 EHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQ 140
E + Q+ E+ ++R+L H NIV Y D I+ ++ + I+M++C GG + +++ +
Sbjct: 46 EAEKQMLVSEVNLLRELK-HPNIVRYYDRIIDRTNT----TLYIVMEYCEGGDLASVITK 100
Query: 141 --RLQTGFTENEVLQIFCDTCEAVARLHQCKT---PIIHRDLKVENILLHDRGHYVLCDF 195
+ + E VL++ A+ H+ ++HRDLK N+ L + + L DF
Sbjct: 101 GTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDF 160
Query: 196 GSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 255
G A + N T T Y +PE +N S K+DIW+LGCLLY+L
Sbjct: 161 GLA--RILNHDTSFAKTFVG------TPYYMSPEQMNRMS---YNEKSDIWSLGCLLYEL 209
Query: 256 CYFTLP---FGESQVA--ICDGNF-TIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 307
C P F + ++A I +G F IP RYS +++ +I ML RP + ++
Sbjct: 210 CALMPPFTAFSQKELAGKIREGKFRRIP--YRYSDELNEIITRMLNLKDYHRPSVEEI 265
>gi|110347429 mediator complex subunit 12 [Homo sapiens]
Length = 2177
Score = 82.4 bits (202), Expect = 2e-15
Identities = 99/340 (29%), Positives = 124/340 (36%), Gaps = 95/340 (27%)
Query: 325 QNSPIPAKLP--EPVKASEAAAKKTQPKARLTDPIPTT------------ETSIAPRQRP 370
QN P+PA P +P + +K + +PTT +TS+ +Q+P
Sbjct: 1844 QNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQP 1903
Query: 371 KAGQ-------TQPNPGILPIQPA--LTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQ 421
Q Q + G+L +TP +Q + GL
Sbjct: 1904 AVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTM 1963
Query: 422 APPSQPLPQTQAKQPQAPPTP-------QQTPS--------TQAQGLPAQAQATPQHQQQ 466
PPS Q+ P PT QQ PS T GL + + + Q QQ
Sbjct: 1964 VPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQ 2023
Query: 467 L----------------------FLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVH 504
L +QQQQQQ QQQ QQQQ Q QQ Q H
Sbjct: 2024 TPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQ-----QQQQQQQQQQQQYH 2078
Query: 505 PATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQ 564
QQ QQQ+++ QQQQQQQQQQQQQQ QQQ QQ
Sbjct: 2079 IRQQQ--------------QQQILRQQQQQQQQQQQQQQQQQ-----QQQQQQQQQ---- 2115
Query: 565 QKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQ 604
QQ Q Q AA PQP P +P Q QQ + Q
Sbjct: 2116 -------HQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQ 2148
Score = 68.9 bits (167), Expect = 2e-11
Identities = 74/231 (32%), Positives = 84/231 (36%), Gaps = 23/231 (9%)
Query: 330 PAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALT 389
PA P S + T P T PT +QRP Q P LT
Sbjct: 1959 PAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHL----QQRPSGYVHQQAP---TYGHGLT 2011
Query: 390 PRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQ 449
+R + Q Q S + A Q ++ P Q Q +Q Q QQ Q
Sbjct: 2012 STQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQ 2071
Query: 450 AQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQ 509
Q Q Q QQQ L+QQQQQQQ QQQ QQQQ Q QQ Q A Q
Sbjct: 2072 QQ---QQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQ 2128
Query: 510 PAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQ 560
P Q Q F +Q QQ QQQQQ QQQL Q
Sbjct: 2129 P-------------QPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQ 2166
Score = 63.5 bits (153), Expect = 9e-10
Identities = 48/120 (40%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 439 PPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQ 498
P QQ Q Q Q Q Q QQQ ++QQQQQQ QQQ QQQQ Q Q
Sbjct: 2049 PEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQ 2108
Query: 499 QFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ-----QQQQQQLATALHQ 553
Q Q QQ P Q SQ Q + QQ QQQQQ +Q QQQL+ Q
Sbjct: 2109 QQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQ 2168
Score = 43.5 bits (101), Expect = 0.001
Identities = 50/196 (25%), Positives = 65/196 (33%), Gaps = 12/196 (6%)
Query: 322 PNVQNSPIPAKLPE--PVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNP 379
P+ + P + P P + +P + PT + QR Q P
Sbjct: 1966 PSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTP 2025
Query: 380 GILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAP 439
I + P +A V+ Q Q + Q Q Q +Q Q
Sbjct: 2026 MISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQ- 2084
Query: 440 PTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQ------PPPAQQQPAGTFYQQQ 493
QQ Q Q Q Q Q QQQ +QQQ QQQ PP Q Q F +Q
Sbjct: 2085 ---QQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQG 2141
Query: 494 QAQTQQFQAVHPATQQ 509
QTQQ Q +Q
Sbjct: 2142 LQQTQQQQQTAALVRQ 2157
Score = 38.5 bits (88), Expect = 0.030
Identities = 40/148 (27%), Positives = 56/148 (37%), Gaps = 7/148 (4%)
Query: 343 AAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQA 402
+A+ Q R T +P + +Q+ + Q Q Q + +++ + Q
Sbjct: 2034 SAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQ 2093
Query: 403 AGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQ 462
Q Q + Q Q Q QA PQ P PQ P Q QGL Q T Q
Sbjct: 2094 QQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQ--PQPQSQPQFQRQGL----QQTQQ 2147
Query: 463 HQQQLFLKQQQQQQQPPPAQQQPAGTFY 490
QQ L +Q QQQ Q QP+ +
Sbjct: 2148 QQQTAALVRQLQQQLSN-TQPQPSTNIF 2174
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 81.6 bits (200), Expect = 3e-15
Identities = 78/262 (29%), Positives = 121/262 (46%), Gaps = 33/262 (12%)
Query: 50 EVLAEGGFAIVFLVRTSNGMKCA-LKRMFVNNEHDLQVCKR-EIQIMRDLSGHKNIVGYI 107
+VL +G F VFLVR G L M V + L+V R ++ RD+ N +
Sbjct: 77 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIV 136
Query: 108 DSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQ 167
+ G ++ +++DF RGG V +++ + FTE +V + A+ LHQ
Sbjct: 137 KLHYAFQTEGKLY---LILDFLRGGDVFTRLSKEVL--FTEEDVKFYLAELALALDHLHQ 191
Query: 168 CKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT---TLS 224
I++RDLK ENILL + GH L DFG + +V+ E K Y+ T+
Sbjct: 192 LG--IVYRDLKPENILLDEIGHIKLTDFGLSK-----------ESVDQEKKAYSFCGTVE 238
Query: 225 YRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-----GESQVAICDGNFTIPDN 279
Y APE+VN + AD W+ G L++++ TLPF E+ I +P
Sbjct: 239 YMAPEVVNRRGH---SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP-- 293
Query: 280 SRYSQDMHCLIRYMLEPDPDKR 301
S + L+R + + +P R
Sbjct: 294 QFLSAEAQSLLRMLFKRNPANR 315
Score = 57.0 bits (136), Expect = 8e-08
Identities = 76/298 (25%), Positives = 125/298 (41%), Gaps = 42/298 (14%)
Query: 90 EIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTEN 149
EI+I+ H NI+ D D V ++ D +GG++++ + + Q F+E
Sbjct: 467 EIEILMRYGQHPNIITLKDVF------DDGRYVYLVTDLMKGGELLDRILK--QKCFSER 518
Query: 150 EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYV----LCDFGSATNKFQNP 205
E I + V LH C+ ++HRDLK NIL D +CDFG A
Sbjct: 519 EASDILYVISKTVDYLH-CQG-VVHRDLKPSNILYMDESASADSIRICDFGFA------K 570
Query: 206 QTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-- 263
Q G N + + T ++ APE++ + G DIW+LG L Y + PF
Sbjct: 571 QLRGENGL--LLTPCYTANFVAPEVL-MQQG--YDAACDIWSLGVLFYTMLAGYTPFANG 625
Query: 264 ------ESQVAICDGNFTIPDNS--RYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLL 315
E + I +G F++ + S L+ +ML DP +R Q+ S+
Sbjct: 626 PNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITH 685
Query: 316 KKECPIPNVQNSPIPAKLPEPVKASEAAA--KKTQPKARLTDPIPTTETSIAPRQRPK 371
+ + P + + + + + A+ +A K QP P +S+A R+ K
Sbjct: 686 RDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLE-----PVAASSLAQRRSMK 738
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,883,960
Number of Sequences: 37866
Number of extensions: 2554613
Number of successful extensions: 51558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 803
Number of HSP's successfully gapped in prelim test: 1967
Number of HSP's that attempted gapping in prelim test: 18348
Number of HSP's gapped (non-prelim): 15563
length of query: 961
length of database: 18,247,518
effective HSP length: 112
effective length of query: 849
effective length of database: 14,006,526
effective search space: 11891540574
effective search space used: 11891540574
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.