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Search of human proteins with 14780902
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
(637 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 1296 0.0
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 456 e-128
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 410 e-114
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 308 1e-83
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 169 7e-42
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 169 9e-42
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 169 9e-42
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 164 2e-40
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 157 4e-38
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 156 6e-38
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 154 2e-37
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 154 3e-37
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 152 9e-37
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 151 2e-36
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 147 4e-35
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 129 1e-29
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 122 1e-27
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 122 1e-27
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 117 4e-26
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 117 4e-26
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 109 7e-24
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 109 7e-24
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 109 7e-24
gi|95089461 discs large homolog 5 [Homo sapiens] 68 3e-11
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 66 9e-11
gi|8922944 lin-7 homolog C [Homo sapiens] 59 1e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 58 2e-08
gi|4759306 lin-7 homolog A [Homo sapiens] 57 4e-08
gi|45827729 scribble isoform b [Homo sapiens] 57 5e-08
gi|45827731 scribble isoform a [Homo sapiens] 57 5e-08
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 1296 bits (3354), Expect = 0.0
Identities = 637/637 (100%), Positives = 637/637 (100%)
Query: 1 MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSP 60
MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSP
Sbjct: 1 MIQSDKGADPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSP 60
Query: 61 WLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFK 120
WLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFK
Sbjct: 61 WLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFK 120
Query: 121 ALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVA 180
ALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVA
Sbjct: 121 ALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVA 180
Query: 181 RIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVN 240
RIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVN
Sbjct: 181 RIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVN 240
Query: 241 SQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAG 300
SQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAG
Sbjct: 241 SQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAG 300
Query: 301 LVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEEL 360
LVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEEL
Sbjct: 301 LVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEEL 360
Query: 361 SEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ 420
SEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ
Sbjct: 361 SEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ 420
Query: 421 RRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS 480
RRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS
Sbjct: 421 RRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS 480
Query: 481 KETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKP 540
KETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKP
Sbjct: 481 KETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKP 540
Query: 541 YVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIV 600
YVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIV
Sbjct: 541 YVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIV 600
Query: 601 NDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ 637
NDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ
Sbjct: 601 NDSLHDACAQLLSAIQKAQEEPQWVPATWISSDTESQ 637
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 456 bits (1172), Expect = e-128
Identities = 245/620 (39%), Positives = 378/620 (60%), Gaps = 52/620 (8%)
Query: 18 LSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKE 77
LST + GL ++L + +L + + L+D+ L +L+KI++ L +++
Sbjct: 4 LSTGSGSDTGLYELLAALPAQLQPHVDSQED-LTFLWDMFGEKSLHSLVKIHEKLHYYEK 62
Query: 78 KKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPL 137
+ VP A L+ ++ E L+ P + EI+EL ++L P+ KALLS HDT+AQK+++P+
Sbjct: 63 QSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPV 122
Query: 138 LPPLPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAG 197
LPP+P++I + E++++I+ LVKN++PLGATIK+ E TG I+VARI+ GG A+RSGL++ G
Sbjct: 123 LPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVG 182
Query: 198 DKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQ-MVYVRAMTEYWPQ 256
D+L EVNG+ VE PE++I ILA S+G I FK++P S S++ ++++A+ +Y P
Sbjct: 183 DELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPN 242
Query: 257 EDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFW 316
ED IPC +AGL F+KGDILQI+ Q+DA WWQA+ +D AGL+PS H +R+
Sbjct: 243 EDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERR----- 297
Query: 317 WSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFI 376
+ E + ++S K
Sbjct: 298 -----------------------------LALRRPEILVQPLKVSNRKS----------- 317
Query: 377 AGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAP-YEEVVRYQRRPSDKYRLIVLMGP 435
+GFR+S RL RK + C Y P YEEV Y+R+ ++KYRL+VL+GP
Sbjct: 318 SGFRKSFRL-SRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGP 376
Query: 436 SGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLE 495
GVG+NEL+R+L+ + H+ VPHTTR ++S E +G EY ++SK FE + +++ +E
Sbjct: 377 VGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIE 436
Query: 496 YGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQ 555
YGEYK + YGTS+D+V++VL + K+C++D++P ++ +RT E KPYVIFIKP ++ +++
Sbjct: 437 YGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRE 496
Query: 556 SRKNAKVIT---DYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLL 612
+RKNAK+I+ D F +ED QEM AQ ME+Q+G FD +I+ND L A +L
Sbjct: 497 TRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELK 556
Query: 613 SAIQKAQEEPQWVPATWISS 632
+ K + E WVP +W+ S
Sbjct: 557 TTFDKLETETHWVPVSWLHS 576
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 410 bits (1054), Expect = e-114
Identities = 233/613 (38%), Positives = 364/613 (59%), Gaps = 44/613 (7%)
Query: 26 NGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATP 85
+GL + L L+ +L S + L D+ L L+KI++ L+ ++ + P
Sbjct: 8 SGLHETLALLTSQLRPD-SNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLH 66
Query: 86 HAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNI 145
A L+ +V+E L+ + +EL Q+L PH +A+L HDT+AQK+F+P+LPPLPDNI
Sbjct: 67 SAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNI 126
Query: 146 PES--EEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEV 203
E EE+++IV LVKN++PLGATI+R E +G ++VARI+ GG A+RSGL++ GD+L EV
Sbjct: 127 DEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 204 NGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVN-SQQMVYVRAMTEYWPQEDPDIP 262
NG++V P+++ ILA S+G+I K++P + + V++RA+ Y P+ED IP
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIP 246
Query: 263 CMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQ 322
C +AGLPFQ+ +L++V Q+D WWQA+++ D AGL+PS +R+
Sbjct: 247 CQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLS--------- 297
Query: 323 PHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFIAGFRRS 382
+ TL S + D+ C D+ET + E GY + ++AG RRS
Sbjct: 298 -YRRAAGTLP-SPQSLRKPPYDQPC---DKETCDCE----------GYLKGHYVAGLRRS 342
Query: 383 MRL-CRRKSHLSPLHASVCCTGSCYSAVGAP----YEEVVRYQRRPSDKYRLIVLMGPSG 437
RL CR + S G S +P YEEV RYQ +P ++ RL+VL+G G
Sbjct: 343 FRLGCRERLGGSQ-------EGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLG 395
Query: 438 VGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYG 497
++EL+++++ NP HF AVPHTTR +KS+E G EYH+VSK+ FE ++ ++ LE+G
Sbjct: 396 ARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHG 455
Query: 498 EYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSR 557
EYK +LYGTS++A+Q V+ + K+C++D+EP+ ++ +RT E KPY+IF+KP+ +++ R
Sbjct: 456 EYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPA----IQEKR 511
Query: 558 KNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQK 617
K + DE QEM A ++ +G D V+V + L A +QL ++K
Sbjct: 512 KTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEK 571
Query: 618 AQEEPQWVPATWI 630
++ WVP +W+
Sbjct: 572 LSKDTHWVPVSWV 584
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 308 bits (789), Expect = 1e-83
Identities = 201/603 (33%), Positives = 321/603 (53%), Gaps = 77/603 (12%)
Query: 40 SLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKL--VPATPHAQVLSYEVVEL 97
+L S+ + LL L+ + Q KI++ + K P +AQ L+ EV +
Sbjct: 137 TLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTV 196
Query: 98 LRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPES-----EEAM 152
L+ E QEL +L PH +ALL AHD +A+++ + L P + + ES E +
Sbjct: 197 LKPVHHK-EGQELTALLNTPHIQALLLAHDKVAEQEMQ-LEPITDERVYESIGQYGGETV 254
Query: 153 RIVCLVKNQQ-PLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGL 211
+IV + K + PLGAT+ R+EM ++++RI+ GG AE+SGLL+ GD+++E+NG+ + G
Sbjct: 255 KIVRIEKARDIPLGATV-RNEMDS-VIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGK 312
Query: 212 DPEQVIHILAMSRGTIMFKVVPVSD--PPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLP 269
D +V +L+ GT+ F ++P PP + +++V+A +Y P +DP +PC + GL
Sbjct: 313 DVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLS 372
Query: 270 FQKGDILQIVDQNDALWWQARKISDPAT--CAGLVPSNHLLKRKQREFWWSQPYQPHTCL 327
FQKGDIL ++ Q D WWQA + D AGLVP ++QRE +
Sbjct: 373 FQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSF--QQQRE-----------AM 419
Query: 328 KSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCR 387
K T+ E E K+ C + +++ + + +K + Y + +
Sbjct: 420 KQTIEEDKEPEKSGKL--WCAKKNKKKRKKVLYNANKND--DYDNEEILT---------- 465
Query: 388 RKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQL 447
YEE+ Y + P+++ R I+L+GP G NELR++L
Sbjct: 466 -------------------------YEEMSLYHQ-PANRKRPIILIGPQNCGQNELRQRL 499
Query: 448 IEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTS 507
+ F SAVPHTTR+++ E+ GR+YH+VS++ FE I + + +E+GE++ +LYGTS
Sbjct: 500 MNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTS 559
Query: 508 VDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYY 567
+D+V+ V+ GKIC++ L Q ++ +R +LKPY+IFI P + Q R A + +
Sbjct: 560 IDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS-----QERLRALLAKE-- 612
Query: 568 VDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
K E+L+E+ + ME G +FD IVN L A +LL I K EPQWVP+
Sbjct: 613 -GKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPS 671
Query: 628 TWI 630
TW+
Sbjct: 672 TWL 674
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 169 bits (428), Expect = 7e-42
Identities = 136/508 (26%), Positives = 235/508 (46%), Gaps = 83/508 (16%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R V L + LG I E I ++ I+ GG A+ SG L GD+++ VN V +
Sbjct: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 213 PEQV----------IHILAMSR----GTIMFKVVPVSDPPVNS-------------QQMV 245
EQ + I+A R K+ + + +NS ++ +
Sbjct: 525 HEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSL 584
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATC--AGLVP 303
YVRA+ +Y +D +P GL F+ GDIL +++ +D WWQAR+++ G++P
Sbjct: 585 YVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIP 642
Query: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
S +++K+R K V+ + +T + + D
Sbjct: 643 SKRRVEKKERARL-----------------------------KTVKFNSKTRDKGQSFND 673
Query: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQ--- 420
K + + +KF F ++ +++ + H + + S S G E V+ Y+
Sbjct: 674 KRKKNLFSRKF---PFYKNKDQSEQETSDADQHVTSNASDSESSYRGQE-EYVLSYEPVN 729
Query: 421 RRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV- 479
++ + R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V
Sbjct: 730 QQEVNYTRPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVT 786
Query: 480 SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELK 539
S+E E I H+ +E G+Y HLYGTSV +V+ V +GK C++D+ I+ ++ +L
Sbjct: 787 SREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLY 846
Query: 540 PYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVI 599
P IFIKP +M + + K + +E ++ A ++E +F + F ++
Sbjct: 847 PISIFIKPKSMENIMEMNK------------RLTEEQARKTFERAMKLEQEFTEHFTAIV 894
Query: 600 VNDSLHDACAQLLSAIQKAQEEPQWVPA 627
D+L D Q+ I++ WVPA
Sbjct: 895 QGDTLEDIYNQVKQIIEEQSGSYIWVPA 922
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/92 (35%), Positives = 47/92 (51%), Gaps = 7/92 (7%)
Query: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
P SE+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 312 PVSEKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231
L+ VN V +E + E+ + L + + KV
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 169 bits (427), Expect = 9e-42
Identities = 134/505 (26%), Positives = 226/505 (44%), Gaps = 88/505 (17%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R V L K LG I E I V+ I+ GG A+ SG L GD+++ VNG+ + G
Sbjct: 525 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
Query: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245
EQ L + T+ K+ + + +N ++ +
Sbjct: 585 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 644
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303
YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ + G++P
Sbjct: 645 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 702
Query: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
S ++RK+R + + K + S +D + ++++E SE
Sbjct: 703 SKRRVERKERARLKTVKFNA----KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQ 758
Query: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
+ GQ+ I YE V R +
Sbjct: 759 ETSDPERGQEDLILS----------------------------------YEPVTRQEINY 784
Query: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 785 T---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 838
Query: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+ ++ +L P
Sbjct: 839 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 898
Query: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
IFIKP ++ + + K + +E ++ + A ++E +FG++F ++ D
Sbjct: 899 IFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 946
Query: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
+L D Q I++ W+P+
Sbjct: 947 TLEDIYNQCKLVIEEQSGPFIWIPS 971
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Query: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
L K + LG +I + GD I V +II GG A++ G L GD+L+ VN S+E
Sbjct: 301 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
Query: 211 LDPEQVIHILAMSRGTIMFKV 231
+ E+ + IL + + KV
Sbjct: 361 VTHEEAVAILKNTSEVVYLKV 381
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 169 bits (427), Expect = 9e-42
Identities = 134/505 (26%), Positives = 226/505 (44%), Gaps = 88/505 (17%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R V L K LG I E I V+ I+ GG A+ SG L GD+++ VNG+ + G
Sbjct: 420 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
Query: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245
EQ L + T+ K+ + + +N ++ +
Sbjct: 480 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 539
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303
YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ + G++P
Sbjct: 540 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 597
Query: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
S ++RK+R + + K + S +D + ++++E SE
Sbjct: 598 SKRRVERKERARLKTVKFNA----KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQ 653
Query: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
+ GQ+ I YE V R +
Sbjct: 654 ETSDPERGQEDLILS----------------------------------YEPVTRQEINY 679
Query: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 680 T---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 733
Query: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+ ++ +L P
Sbjct: 734 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 793
Query: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
IFIKP ++ + + K + +E ++ + A ++E +FG++F ++ D
Sbjct: 794 IFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 841
Query: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
+L D Q I++ W+P+
Sbjct: 842 TLEDIYNQCKLVIEEQSGPFIWIPS 866
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Query: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
L K + LG +I + GD I V +II GG A++ G L GD+L+ VN S+E
Sbjct: 196 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 255
Query: 211 LDPEQVIHILAMSRGTIMFKV 231
+ E+ + IL + + KV
Sbjct: 256 VTHEEAVAILKNTSEVVYLKV 276
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 164 bits (415), Expect = 2e-40
Identities = 135/505 (26%), Positives = 222/505 (43%), Gaps = 99/505 (19%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R V L + LG I E I ++ I+ GG A+ SG L GD+++ VN V +
Sbjct: 465 RKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 213 PEQV----------IHILAMSR----GTIMFKVVPVSDPPVNS-------------QQMV 245
EQ + I+A R K+ + + +NS ++ +
Sbjct: 525 HEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSL 584
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATC--AGLVP 303
YVRA+ +Y +D +P GL F+ GDIL +++ +D WWQAR+++ G++P
Sbjct: 585 YVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIP 642
Query: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
S +++K+R + + T K E DDM + +SE
Sbjct: 643 SKRRVEKKERARLKTVKFNSKTRDKG------EIPDDMG-SKGLKHVTSNASDSESSYRG 695
Query: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
+EE+V YE V ++
Sbjct: 696 QEEYV------------------------------------------LSYEPV---NQQE 710
Query: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 711 VNYTRPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSRE 767
Query: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
E I H+ +E G+Y HLYGTSV +V+ V +GK C++D+ I+ ++ +L P
Sbjct: 768 QMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPIS 827
Query: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
IFIKP +M + + K + +E ++ A ++E +F + F ++ D
Sbjct: 828 IFIKPKSMENIMEMNK------------RLTEEQARKTFERAMKLEQEFTEHFTAIVQGD 875
Query: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
+L D Q+ I++ WVPA
Sbjct: 876 TLEDIYNQVKQIIEEQSGSYIWVPA 900
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/92 (35%), Positives = 47/92 (51%), Gaps = 7/92 (7%)
Query: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
P SE+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 312 PVSEKIMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231
L+ VN V +E + E+ + L + + KV
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 157 bits (396), Expect = 4e-38
Identities = 107/334 (32%), Positives = 168/334 (50%), Gaps = 37/334 (11%)
Query: 9 DPPDK-----KDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQ 63
DPP++ +D S + +SQ+L L+E+ + L+ + L
Sbjct: 323 DPPEELPDFSEDPTSSGLLAAERAVSQVLDS-LEEIHALTDCSEKDLDFLHSVFQDQHLH 381
Query: 64 ALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALL 123
LL +YD + ++ A + EV+E + P + + +EL+++L PHF ALL
Sbjct: 382 TLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALL 441
Query: 124 SAHDTIAQKDFE---------PLLPPLPDNIPESEEA---------MRIVCLVKN-QQPL 164
HD +A + + P P L + PES +R+V KN +P+
Sbjct: 442 QTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPM 501
Query: 165 GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR 224
G T+K +E+ +VARI+HGG+ R G L+ GD++ E+NG+SV EQ+ +L R
Sbjct: 502 GITLKMNELN-HCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMR 560
Query: 225 GTIMFKVVP--------VSDPPVNSQ---QMVYVRAMTEYWPQEDPDIPCMDAGLPFQKG 273
G+I FK+VP D P +Q + +YVRA EY P +D IPC +AG+ F+ G
Sbjct: 561 GSITFKIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVG 620
Query: 274 DILQIVDQNDALWWQARKISDPATCAGLVPSNHL 307
DI+QI+ ++D WWQ + + AGL+PS L
Sbjct: 621 DIIQIISKDDHNWWQGKLENSKNGTAGLIPSPEL 654
Score = 130 bits (326), Expect = 5e-30
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 20/218 (9%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEVV+ P+ K + +VL+G GVG ++ LI +P F +PHTTR K E N
Sbjct: 700 YEEVVKL---PAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEEN 756
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+ Y++VS + I ++ LEYG ++ +YGT ++ ++ + +G I ++D+EPQ ++
Sbjct: 757 GKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKV 816
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
+RT E P+V+FI A IT + DE LQ ++ + ++ +
Sbjct: 817 LRTAEFAPFVVFIA-------------APTITPGLNE----DESLQRLQKESDILQRTYA 859
Query: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD I+N+ + + L A++ PQWVP +W+
Sbjct: 860 HYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 897
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 156 bits (394), Expect = 6e-38
Identities = 106/329 (32%), Positives = 165/329 (50%), Gaps = 33/329 (10%)
Query: 9 DPPDKKDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKI 68
DPP++ S +SQ+L L+E+ + L+ + L LL +
Sbjct: 323 DPPEELP-DFSEDPTSSGAVSQVLDS-LEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDL 380
Query: 69 YDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDT 128
YD + ++ A + EV+E + P + + +EL+++L PHF ALL HD
Sbjct: 381 YDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDV 440
Query: 129 IAQKDFE---------PLLPPLPDNIPESEEA---------MRIVCLVKN-QQPLGATIK 169
+A + + P P L + PES +R+V KN +P+G T+K
Sbjct: 441 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 500
Query: 170 RHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMF 229
+E+ +VARI+HGG+ R G L+ GD++ E+NG+SV EQ+ +L RG+I F
Sbjct: 501 MNELN-HCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 559
Query: 230 KVVP--------VSDPPVNSQ---QMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQI 278
K+VP D P +Q + +YVRA EY P +D IPC +AG+ F+ GDI+QI
Sbjct: 560 KIVPSYRTQSSSCEDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQI 619
Query: 279 VDQNDALWWQARKISDPATCAGLVPSNHL 307
+ ++D WWQ + + AGL+PS L
Sbjct: 620 ISKDDHNWWQGKLENSKNGTAGLIPSPEL 648
Score = 130 bits (326), Expect = 5e-30
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 20/218 (9%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEVV+ P+ K + +VL+G GVG ++ LI +P F +PHTTR K E N
Sbjct: 699 YEEVVKL---PAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEEN 755
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+ Y++VS + I ++ LEYG ++ +YGT ++ ++ + +G I ++D+EPQ ++
Sbjct: 756 GKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKV 815
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
+RT E P+V+FI A IT + DE LQ ++ + ++ +
Sbjct: 816 LRTAEFAPFVVFIA-------------APTITPGLNE----DESLQRLQKESDILQRTYA 858
Query: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD I+N+ + + L A++ PQWVP +W+
Sbjct: 859 HYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 896
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 154 bits (390), Expect = 2e-37
Identities = 127/511 (24%), Positives = 227/511 (44%), Gaps = 86/511 (16%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R + L K LG I E I V+ I+ GG A+ SG L GD+++ VNGV++
Sbjct: 48 RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 107
Query: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS-------------QQMV 245
EQ L + ++ K+ + + +NS ++ +
Sbjct: 108 HEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSL 167
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCA--GLVP 303
YVRA+ +Y D +P GL F GDIL +++ +D WWQAR ++ G++P
Sbjct: 168 YVRALFDYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIP 225
Query: 304 SNHLLKRKQREFWWSQPYQPHT-CLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSE 362
S +++K+R + + T ++S SI + + ++ K
Sbjct: 226 SKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFP-------------- 271
Query: 363 DKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAP-----YEEVV 417
F +S ++S + + + S S+ G YE V
Sbjct: 272 ----------------FYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVT 315
Query: 418 RYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYH 477
R + + R ++++GP VN+ LI P F S VPHTTR ++ E++G++YH
Sbjct: 316 RQEIHYA---RPVIILGPMKDRVND---DLISEFPHKFGSCVPHTTRPRRDNEVDGQDYH 369
Query: 478 YV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTH 536
+V S+E E I ++ +E G++ +LYGTS+ +V+ V GK C++D+ I+ ++
Sbjct: 370 FVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQA 429
Query: 537 ELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFD 596
+L P IFIKP ++ + + + E ++ + A ++E +FG++F
Sbjct: 430 QLYPIAIFIKPKSIEALMEMNRRQTY------------EQANKIYDKAMKLEQEFGEYFT 477
Query: 597 HVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
++ DSL + ++ I+ WVP+
Sbjct: 478 AIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 508
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 154 bits (388), Expect = 3e-37
Identities = 78/219 (35%), Positives = 131/219 (59%), Gaps = 7/219 (3%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEV + P + + +VL+G GVG L+ + I NP+ F + VP T+R + E +
Sbjct: 327 YEEVAKM---PPFQRKTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKD 383
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+ Y +VS+ E I + + LE+GEY+G+LYGT +D++ V+ G+ C++D+ PQ ++
Sbjct: 384 GQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKV 443
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMK-FKDEDLQEMENLAQRMETQF 591
+RT E PYV+FI + + R K + D + K D DL++ + + R++ +
Sbjct: 444 LRTSEFMPYVVFIAAPELETL---RAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAY 500
Query: 592 GQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD +I+ND+L A +L +AI+K + EPQWVP +W+
Sbjct: 501 NHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISWV 539
Score = 140 bits (354), Expect = 3e-33
Identities = 91/268 (33%), Positives = 156/268 (58%), Gaps = 16/268 (5%)
Query: 53 LYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPE-IQELR 111
L ++ +P +++L K ++ L++ KL + + L E++E + E + EL
Sbjct: 25 LKGIMENPIVKSLAKAHERLED---SKLEAVSDNNLELVNEILEDITPLINVDENVAELV 81
Query: 112 QMLQAPHFKALLSAHDTIAQK--DFEPLLPPLPDNIPESE----EAMRIVCLVKNQ-QPL 164
+L+ PHF++LL AHD +A K D P P + ++ ++ +A+RI+ + K +PL
Sbjct: 82 GILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPL 141
Query: 165 GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR 224
G T + D+++ARI+HGG+ +R GLL+ GD + EVNG V G +P+++ +L
Sbjct: 142 GVTFRVEN--NDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNIS 198
Query: 225 GTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDA 284
G++ K++P + QQ V+V+ +Y P D IPC +AGL F KG+ILQIV++ D
Sbjct: 199 GSVTLKILPSYRDTITPQQ-VFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNREDP 257
Query: 285 LWWQARKISDPATCAGLVPSNHLLKRKQ 312
WWQA + + + AGL+PS L ++++
Sbjct: 258 NWWQASHVKEGGS-AGLIPSQFLEEKRK 284
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 152 bits (384), Expect = 9e-37
Identities = 105/302 (34%), Positives = 169/302 (55%), Gaps = 18/302 (5%)
Query: 21 ATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKL 80
ATN + + Q+L + S + +++ + L ++ SP +++L K ++ L+E KL
Sbjct: 5 ATNSETAMQQVLDNLGSLPSATGAAELD-LIFLRGIMESPIVRSLAKAHERLEE---TKL 60
Query: 81 VPATPHAQVLSYEVV-ELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFE---- 135
+ L E++ +L S EL +LQ PHF++LL HD++A K +E
Sbjct: 61 EAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPP 120
Query: 136 -PLLPPLPDNIPESEEAMRIVCLVKNQ-QPLGATIKRHEMTGDILVARIIHGGLAERSGL 193
P L P N P +A+R+V + K + LG T + G++++ARI+HGG+ + GL
Sbjct: 121 SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEG--GELVIARILHGGMVAQQGL 178
Query: 194 LYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEY 253
L+ GD + EVNG V G DP + +L + G+++ K++P P +Q V+V+ +Y
Sbjct: 179 LHVGDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQEPHLPRQ-VFVKCHFDY 236
Query: 254 WPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQR 313
P D IPC +AGL F GD+LQIV+Q+DA WWQA + + AGL+PS LL+ K++
Sbjct: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS--AGLIPS-QLLEEKRK 293
Query: 314 EF 315
F
Sbjct: 294 AF 295
Score = 152 bits (384), Expect = 9e-37
Identities = 75/218 (34%), Positives = 129/218 (59%), Gaps = 5/218 (2%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEV R P + + +VL+G GVG L+ +LI ++P + + VP+T+R K E
Sbjct: 339 YEEVARM---PPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+ Y +VS+ E + + R LE+GEY+G+LYGT +D+++ V+ GK+CV+D+ PQ ++
Sbjct: 396 GQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKV 455
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
+RT E PYV+FI+ + ++ N + + + DL+ + R++ +G
Sbjct: 456 LRTAEFVPYVVFIEAPDFETLR--AMNRAALESGISTKQLTEADLRRTVEESSRIQRGYG 513
Query: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD +VN +L +L +A++K + EPQWVP +W+
Sbjct: 514 HYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWV 551
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 151 bits (382), Expect = 2e-36
Identities = 109/357 (30%), Positives = 170/357 (47%), Gaps = 60/357 (16%)
Query: 9 DPPDK-----KDMKLSTATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQ 63
DPP++ +D S + +SQ+L L+E+ + L+ + L
Sbjct: 323 DPPEELPDFSEDPTSSGLLAAERAVSQVLDS-LEEIHALTDCSEKDLDFLHSVFQDQHLH 381
Query: 64 ALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALL 123
LL +YD + ++ A + EV+E + P + + +EL+++L PHF ALL
Sbjct: 382 TLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALL 441
Query: 124 SAHDTIAQKDFE---------PLLPPLPDNIPESEEA---------MRIVCLVKN-QQPL 164
HD +A + + P P L + PES +R+V KN +P+
Sbjct: 442 QTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPM 501
Query: 165 GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR 224
G T+K +E+ +VARI+HGG+ R G L+ GD++ E+NG+SV EQ+ +L R
Sbjct: 502 GITLKMNELN-HCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMR 560
Query: 225 GTIMFKVVP-------------------------------VSDPPVNSQ---QMVYVRAM 250
G+I FK+VP VSD P +Q + +YVRA
Sbjct: 561 GSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQ 620
Query: 251 TEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHL 307
EY P +D IPC +AG+ F+ GDI+QI+ ++D WWQ + + AGL+PS L
Sbjct: 621 FEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPEL 677
Score = 130 bits (326), Expect = 5e-30
Identities = 69/218 (31%), Positives = 117/218 (53%), Gaps = 20/218 (9%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEVV+ P+ K + +VL+G GVG ++ LI +P F +PHTTR K E N
Sbjct: 723 YEEVVKL---PAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEEN 779
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+ Y++VS + I ++ LEYG ++ +YGT ++ ++ + +G I ++D+EPQ ++
Sbjct: 780 GKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKV 839
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
+RT E P+V+FI A IT + DE LQ ++ + ++ +
Sbjct: 840 LRTAEFAPFVVFIA-------------APTITPGLNE----DESLQRLQKESDILQRTYA 882
Query: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD I+N+ + + L A++ PQWVP +W+
Sbjct: 883 HYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 920
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 147 bits (370), Expect = 4e-35
Identities = 73/218 (33%), Positives = 124/218 (56%), Gaps = 23/218 (10%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YEEVVR P+ K + +VL+G SGVG + ++ L+ NP F VP+TTR + E +
Sbjct: 271 YEEVVRL---PAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEED 327
Query: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
G+EYH++S E I ++ LE+G Y+G+++GT + V + + KI ++D+EPQ ++
Sbjct: 328 GKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKI 387
Query: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
VRT EL P+++FI P+ D + E LQ+++ ++ + +Q+
Sbjct: 388 VRTAELSPFIVFIAPT--------------------DQGTQTEALQQLQKDSEAIRSQYA 427
Query: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
+FD +VN+ + + +L A +A PQWVP +W+
Sbjct: 428 HYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465
Score = 116 bits (290), Expect = 7e-26
Identities = 60/166 (36%), Positives = 98/166 (59%), Gaps = 2/166 (1%)
Query: 161 QQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
++P+G T+K +E VARI+HGG+ R G L+ GD+++E+NG +V +Q+ +
Sbjct: 79 EEPMGITLKLNEKQS-CTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAM 137
Query: 221 AMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVD 280
++G I KV+P + + QM ++RA +Y P++D IPC +AGL F GDI+QI++
Sbjct: 138 KETKGMISLKVIPNQQSRLPALQM-FMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIIN 196
Query: 281 QNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTC 326
++D+ WWQ R AGL+PS L + + S P + +C
Sbjct: 197 KDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSC 242
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 129 bits (323), Expect = 1e-29
Identities = 122/519 (23%), Positives = 217/519 (41%), Gaps = 105/519 (20%)
Query: 140 PLPDNIPESEEAMRI---VCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYA 196
P+P ++ E+ R + L K LG I E I V+ I+ GG A+ SG L
Sbjct: 369 PIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRR 428
Query: 197 GDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS- 241
GD+++ VNGV++ EQ L + ++ K+ + + +NS
Sbjct: 429 GDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSS 488
Query: 242 ------------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQA 289
++ +YVRA+ +Y D +P GL F GDIL
Sbjct: 489 MSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSFSYGDIL------------- 533
Query: 290 RKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVE 349
H++ E+W ++ PH + I ++ + K E+
Sbjct: 534 ----------------HVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKK--ERARL 575
Query: 350 ADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAV 409
+ + E +F G ++ A + + + LS
Sbjct: 576 KTVKFHARTGMIESNRDFPGLSDDYYGAKNLKG----QEDAILS---------------- 615
Query: 410 GAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSY 469
YE V R + + R ++++GP VN+ LI P F S VPHTTR ++
Sbjct: 616 ---YEPVTRQEIHYA---RPVIILGPMKDRVND---DLISEFPHKFGSCVPHTTRPRRDN 666
Query: 470 EMNGREYHYV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQ 528
E++G++YH+V S+E E I ++ +E G++ +LYGTS+ +V+ V GK C++D+
Sbjct: 667 EVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGN 726
Query: 529 DIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRME 588
I+ ++ +L P IFIKP ++ + + + E ++ + A ++E
Sbjct: 727 AIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTY------------EQANKIYDKAMKLE 774
Query: 589 TQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
+FG++F ++ DSL + ++ I+ WVP+
Sbjct: 775 QEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 813
Score = 40.0 bits (92), Expect = 0.007
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 150 EAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEV 203
E + V L+K + LG +I + GD I + +II GG A++ G L GD+L+ V
Sbjct: 222 ETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAV 281
Query: 204 NGVSVEGLDPEQVIHILAMSRGTIMFKV 231
N +++ + E+ + L + + KV
Sbjct: 282 NNTNLQDVRHEEAVASLKNTSDMVYLKV 309
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 122 bits (305), Expect = 1e-27
Identities = 69/216 (31%), Positives = 117/216 (54%), Gaps = 19/216 (8%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YE V R + + R ++++GP +N+ LI P F S VPHTTR K+ YE++
Sbjct: 548 YEPVTRQEINYT---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVD 601
Query: 473 GREYHYV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQ 531
GR+YH+V S+E E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+
Sbjct: 602 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 661
Query: 532 GVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQF 591
++ +L P IFIKP ++ + + K + +E ++ + A ++E +F
Sbjct: 662 RLQVAQLYPIAIFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEF 709
Query: 592 GQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
G++F ++ D+L D Q I++ W+P+
Sbjct: 710 GEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Score = 75.1 bits (183), Expect = 2e-13
Identities = 56/190 (29%), Positives = 89/190 (46%), Gaps = 31/190 (16%)
Query: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
R V L K LG I E I V+ I+ GG A+ SG L GD+++ VNG+ + G
Sbjct: 317 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376
Query: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245
EQ L + T+ K+ + + +N ++ +
Sbjct: 377 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 436
Query: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303
YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ + G++P
Sbjct: 437 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 494
Query: 304 SNHLLKRKQR 313
S ++RK+R
Sbjct: 495 SKRRVERKER 504
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Query: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
L K + LG +I + GD I V +II GG A++ G L GD+L+ VN S+E
Sbjct: 145 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
Query: 211 LDPEQVIHILAMSRGTIMFKV 231
+ E+ + IL + + KV
Sbjct: 205 VTHEEAVAILKNTSEVVYLKV 225
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 122 bits (305), Expect = 1e-27
Identities = 69/216 (31%), Positives = 117/216 (54%), Gaps = 19/216 (8%)
Query: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
YE V R + + R ++++GP +N+ LI P F S VPHTTR K+ YE++
Sbjct: 133 YEPVTRQEINYT---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVD 186
Query: 473 GREYHYV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQ 531
GR+YH+V S+E E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+
Sbjct: 187 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 246
Query: 532 GVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQF 591
++ +L P IFIKP ++ + + K + +E ++ + A ++E +F
Sbjct: 247 RLQVAQLYPIAIFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEF 294
Query: 592 GQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
G++F ++ D+L D Q I++ W+P+
Sbjct: 295 GEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 330
Score = 57.0 bits (136), Expect = 5e-08
Identities = 28/76 (36%), Positives = 47/76 (61%), Gaps = 4/76 (5%)
Query: 240 NSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPAT 297
N ++ +YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ +
Sbjct: 16 NQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE 73
Query: 298 CAGLVPSNHLLKRKQR 313
G++PS ++RK+R
Sbjct: 74 EMGVIPSKRRVERKER 89
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 117 bits (292), Expect = 4e-26
Identities = 62/201 (30%), Positives = 110/201 (54%), Gaps = 16/201 (7%)
Query: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS-KETFEN 486
R I+++GP+ N+ L+ P F S VPHTTR K+ YE++GR+YH+VS +E E
Sbjct: 578 RPIIILGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 634
Query: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
I +H+ +E G+Y HLYGTSV +V+ V +GK C++D+ ++ ++ L P IFI+
Sbjct: 635 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 694
Query: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHD 606
P ++ + + ++ + +E ++ + A ++E +F + F ++ DS +
Sbjct: 695 PRSLENVLE------------INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEE 742
Query: 607 ACAQLLSAIQKAQEEPQWVPA 627
++ I+ WVPA
Sbjct: 743 IYHKVKRVIEDLSGPYIWVPA 763
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 38/206 (18%)
Query: 143 DNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVE 202
++IP E RIV + + LG I E I ++ I+ GG A+ SG L GD+++
Sbjct: 348 EDIPR--EPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILS 404
Query: 203 VNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS------- 241
VNGV + EQ L + T+ K+ + + +NS
Sbjct: 405 VNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 464
Query: 242 ------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI-SD 294
++ Y+RA+ +Y + D + L F+ GD+L ++D +D WWQAR++ SD
Sbjct: 465 SLRSNPKRGFYIRALFDY--DKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSD 522
Query: 295 PAT-CAGLVPSNHLLKRKQREFWWSQ 319
T G +PS ++R++ WS+
Sbjct: 523 SETDDIGFIPSKRRVERRE----WSR 544
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
P +E+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 196 PPAEKVMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
++ VN V +E + E + L + + KV S+
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
Score = 30.4 bits (67), Expect = 5.2
Identities = 46/192 (23%), Positives = 71/192 (36%), Gaps = 26/192 (13%)
Query: 53 LYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQ 112
L +LHS QALL I D + + +Q Y+ + T P
Sbjct: 26 LLTVLHSDLFQALLDILDYYE--------ASLSESQKYRYQ------DEDTPPLEHSPAH 71
Query: 113 MLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATI---K 169
+ + ++ DT+ +E L N E E + L + LG +I
Sbjct: 72 LPNQANSPPVIVNTDTLEAPGYE-----LQVNGTEGEMEYEEITLERGNSGLGFSIAGGT 126
Query: 170 RHEMTGD---ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGT 226
+ GD I + +II GG A + G L D ++ VN V V + + L G+
Sbjct: 127 DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL-KEAGS 185
Query: 227 IMFKVVPVSDPP 238
I+ V PP
Sbjct: 186 IVRLYVMRRKPP 197
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 117 bits (292), Expect = 4e-26
Identities = 62/201 (30%), Positives = 110/201 (54%), Gaps = 16/201 (7%)
Query: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS-KETFEN 486
R I+++GP+ N+ L+ P F S VPHTTR K+ YE++GR+YH+VS +E E
Sbjct: 532 RPIIILGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 588
Query: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
I +H+ +E G+Y HLYGTSV +V+ V +GK C++D+ ++ ++ L P IFI+
Sbjct: 589 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 648
Query: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHD 606
P ++ + + ++ + +E ++ + A ++E +F + F ++ DS +
Sbjct: 649 PRSLENVLE------------INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEE 696
Query: 607 ACAQLLSAIQKAQEEPQWVPA 627
++ I+ WVPA
Sbjct: 697 IYHKVKRVIEDLSGPYIWVPA 717
Score = 63.9 bits (154), Expect = 4e-10
Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 38/206 (18%)
Query: 143 DNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVE 202
++IP E RIV + + LG I E I ++ I+ GG A+ SG L GD+++
Sbjct: 302 EDIPR--EPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILS 358
Query: 203 VNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS------- 241
VNGV + EQ L + T+ K+ + + +NS
Sbjct: 359 VNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 418
Query: 242 ------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI-SD 294
++ Y+RA+ +Y + D + L F+ GD+L ++D +D WWQAR++ SD
Sbjct: 419 SLRSNPKRGFYIRALFDY--DKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSD 476
Query: 295 PAT-CAGLVPSNHLLKRKQREFWWSQ 319
T G +PS ++R++ WS+
Sbjct: 477 SETDDIGFIPSKRRVERRE----WSR 498
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
P +E+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 150 PPAEKVMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
Query: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
++ VN V +E + E + L + + KV S+
Sbjct: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 109 bits (273), Expect = 7e-24
Identities = 65/198 (32%), Positives = 113/198 (57%), Gaps = 11/198 (5%)
Query: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENL 487
R +VL GPSG G + L ++L++ + F +V HTTR + E NG++Y++V++E +
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 488 IYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKP 547
I + +E+ E+ G+LYGTS AVQ V +ICV+D++ Q ++ ++ +L+P I ++P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 548 SNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQR-ME-TQFGQFFDHVIVNDSLH 605
++ ++Q + T +E L + AQ ME ++ FD VI+NDSL
Sbjct: 125 PSLHVLEQRLRQRNTET---------EESLVKRLAAAQADMESSKEPGLFDVVIINDSLD 175
Query: 606 DACAQLLSAIQKAQEEPQ 623
A A+L A+ + ++ Q
Sbjct: 176 QAYAELKEALSEEIKKAQ 193
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 109 bits (273), Expect = 7e-24
Identities = 65/198 (32%), Positives = 113/198 (57%), Gaps = 11/198 (5%)
Query: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENL 487
R +VL GPSG G + L ++L++ + F +V HTTR + E NG++Y++V++E +
Sbjct: 26 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 85
Query: 488 IYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKP 547
I + +E+ E+ G+LYGTS AVQ V +ICV+D++ Q ++ ++ +L+P I ++P
Sbjct: 86 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 145
Query: 548 SNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQR-ME-TQFGQFFDHVIVNDSLH 605
++ ++Q + T +E L + AQ ME ++ FD VI+NDSL
Sbjct: 146 PSLHVLEQRLRQRNTET---------EESLVKRLAAAQADMESSKEPGLFDVVIINDSLD 196
Query: 606 DACAQLLSAIQKAQEEPQ 623
A A+L A+ + ++ Q
Sbjct: 197 QAYAELKEALSEEIKKAQ 214
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 109 bits (273), Expect = 7e-24
Identities = 65/198 (32%), Positives = 113/198 (57%), Gaps = 11/198 (5%)
Query: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENL 487
R +VL GPSG G + L ++L++ + F +V HTTR + E NG++Y++V++E +
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 488 IYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKP 547
I + +E+ E+ G+LYGTS AVQ V +ICV+D++ Q ++ ++ +L+P I ++P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 548 SNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQR-ME-TQFGQFFDHVIVNDSLH 605
++ ++Q + T +E L + AQ ME ++ FD VI+NDSL
Sbjct: 125 PSLHVLEQRLRQRNTET---------EESLVKRLAAAQADMESSKEPGLFDVVIINDSLD 175
Query: 606 DACAQLLSAIQKAQEEPQ 623
A A+L A+ + ++ Q
Sbjct: 176 QAYAELKEALSEEIKKAQ 193
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 67.8 bits (164), Expect = 3e-11
Identities = 99/520 (19%), Positives = 197/520 (37%), Gaps = 84/520 (16%)
Query: 124 SAHDTIAQKDFEPLLPP-------LPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGD 176
S D + ++D P PP + + + R+V + K+Q LG + + G
Sbjct: 1465 SVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVFIKKSQLELGVHLCGGNLHG- 1523
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
+ VA + A+ L GD ++E + V E+V + R + KV +
Sbjct: 1524 VFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPE 1583
Query: 237 PPVNSQQM----VYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVD---QNDALWWQA 289
++ + Y+RA+ + + + L F+K DIL + D Q W A
Sbjct: 1584 EFTKAKGLPGDSFYIRALYDRLADVEQE-------LSFKKDDILYVDDTLPQGTFGSWMA 1636
Query: 290 RKISDPATCA--GLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKC 347
++ + A G +PS +++ ++ LS+S ++D+
Sbjct: 1637 WQLDENAQKIQRGQIPSKYVMDQE---------------FSRRLSMSEVKDDNSATKTLS 1681
Query: 348 VEADEETFESEELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYS 407
A F + + G + + L S PL
Sbjct: 1682 AAARRSFFRRKHKHKRSGSKDG----------KDLLALDAFSSDSIPLFED--------- 1722
Query: 408 AVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKK 467
+V Y+ V Q+ R ++++GP ++ ++ L+ P F +
Sbjct: 1723 SVSLAYQRV---QKVDCTALRPVLILGPL---LDVVKEMLVNEAPGKFCRCPLEVMKA-- 1774
Query: 468 SYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEP 527
S++ E + ++Y GH T+V +++ + + + C++D+ P
Sbjct: 1775 ------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAP 1822
Query: 528 QDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRM 587
I+ + + P VIFI + + +K+ R Y+ K +E AQ++
Sbjct: 1823 HAIERLHHMHIYPIVIFIHYKSAKHIKEQRD------PIYLRDKVTQRHSKEQFEAAQKL 1876
Query: 588 ETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627
E ++ ++F VI +L C Q+L+ + + Q + W+PA
Sbjct: 1877 EQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 2/78 (2%)
Query: 150 EAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVE 209
E R V + K +PLG +I E G I V+++ G +A ++GL Y GD+L+E NG+++
Sbjct: 1346 EEPRHVKVQKGSEPLGISIVSGEK-GGIYVSKVTVGSIAHQAGLEY-GDQLLEFNGINLR 1403
Query: 210 GLDPEQVIHILAMSRGTI 227
+Q I+ TI
Sbjct: 1404 SATEQQARLIIGQQCDTI 1421
Score = 30.0 bits (66), Expect = 6.8
Identities = 15/62 (24%), Positives = 32/62 (51%), Gaps = 3/62 (4%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTI---MFKVVP 233
+ A ++ G A + G L GD++V +NG++++ + +L + ++ + KV P
Sbjct: 738 VYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFP 797
Query: 234 VS 235
S
Sbjct: 798 QS 799
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 66.2 bits (160), Expect = 9e-11
Identities = 44/199 (22%), Positives = 87/199 (43%), Gaps = 9/199 (4%)
Query: 427 YRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFEN 486
Y +++L GP G EL +L ++F+ HTTR E + +YH++S++ F+
Sbjct: 414 YPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDE 473
Query: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
++ + + Y H YG + D V+ + +G + +E + ++ ++ +P I +
Sbjct: 474 MVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVV 533
Query: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSL-- 604
P N + + + + ++ DL ++ F +FD VI D L
Sbjct: 534 PMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLY------IKINQNFPGYFDEVINADDLDV 587
Query: 605 -HDACAQLLSAIQKAQEEP 622
+ +QL+ EEP
Sbjct: 588 AYQKLSQLIREYLGLTEEP 606
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 58.9 bits (141), Expect = 1e-08
Identities = 46/154 (29%), Positives = 74/154 (48%), Gaps = 17/154 (11%)
Query: 95 VELLRETPTSPEI-----QELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIP--- 146
+ELL + S E+ Q L+++LQ+ A+ ++ + + P + N
Sbjct: 18 IELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKA 77
Query: 147 --------ESEEAMRIVCLVKNQQPLGATIKR-HEMTGDILVARIIHGGLAERSGLLYAG 197
E R+V L K ++ LG I E I ++RII GG+A+R G L G
Sbjct: 78 TVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRG 137
Query: 198 DKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231
D+L+ VNGVSVEG E+ + +L ++G + V
Sbjct: 138 DQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 58.2 bits (139), Expect = 2e-08
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 4/98 (4%)
Query: 143 DNIPESEEAMRIVCLVKNQQ---PLGATIKRHEMTGD-ILVARIIHGGLAERSGLLYAGD 198
DN E E + I+ V+ ++ PLG TI E D I+++ + GGLAER+G ++ GD
Sbjct: 607 DNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGD 666
Query: 199 KLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
+++ +N S++G + IH+L M+ T+ K+ +D
Sbjct: 667 RILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTD 704
Score = 37.4 bits (85), Expect = 0.043
Identities = 30/101 (29%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 144 NIPESEEAMRIVCLVKNQ-QPLGATIKRH-EMTGDILVARIIHGGLAERSGLLYAGDKLV 201
+IPE + +V L+K + LG T+ + G V+ + GG+A RS L GD +
Sbjct: 43 SIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIK 102
Query: 202 EVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQ 242
VNG+++ +++I +L + G + V PPV+ Q
Sbjct: 103 AVNGINLAKFRHDEIISLL-KNVGERVVLEVEYELPPVSVQ 142
Score = 37.0 bits (84), Expect = 0.056
Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 6/101 (5%)
Query: 159 KNQQPLGATIKR--HEMTGD-ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQ 215
K+ LG TI GD ++++ I G +A R+G L GDKL+ ++ + ++ E
Sbjct: 527 KHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMED 586
Query: 216 VIHILAMSRGTIMFKV---VPVSDPPVNSQQMVYVRAMTEY 253
+ IL + K+ SD +S ++Y + Y
Sbjct: 587 AVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRY 627
Score = 33.5 bits (75), Expect = 0.61
Identities = 14/57 (24%), Positives = 31/57 (54%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVP 233
I++ +I +A+R G L+ GD ++ ++G S+E + LA + + +++P
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP 334
Score = 30.4 bits (67), Expect = 5.2
Identities = 13/44 (29%), Positives = 26/44 (59%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
+++ + GG A+R G + GD+L+ V+G+ + G + + IL
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
Score = 30.0 bits (66), Expect = 6.8
Identities = 15/56 (26%), Positives = 28/56 (50%)
Query: 165 GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
G+ ++ L++ I AER G+L GD+++ +NG+ E E+ +L
Sbjct: 437 GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLL 492
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 57.4 bits (137), Expect = 4e-08
Identities = 49/167 (29%), Positives = 76/167 (45%), Gaps = 14/167 (8%)
Query: 66 LKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSA 125
+++ + LQE E + +VL E +RE + E + P F+A +A
Sbjct: 33 IELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREV--YQYMHETITVNGCPEFRARATA 90
Query: 126 HDTIAQKDFEPLLPPLPDNIPESEEAMRIVCLVKNQQPLGATIKR-HEMTGDILVARIIH 184
T+A E R+V L K + LG + E I ++RII
Sbjct: 91 KATVAAFAAS-----------EGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIP 139
Query: 185 GGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV 231
GG+AER G L GD+L+ VNGVSVEG E+ + +L ++ ++ V
Sbjct: 140 GGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVV 186
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 57.0 bits (136), Expect = 5e-08
Identities = 52/200 (26%), Positives = 85/200 (42%), Gaps = 23/200 (11%)
Query: 43 YSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETP 102
Y D G+ + P +A +++ D L E L A H E VE LR
Sbjct: 751 YKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHH------EAVEALRGAG 804
Query: 103 TSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPL--------LPPLPDNIPESEEAMRI 154
T+ +++ R+ + P ++ + D+ P LP LP P +
Sbjct: 805 TAVQMRVWRERMVEPENAVTITP--LRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHV 862
Query: 155 VCLVKNQQPLGATIKRHE-----MTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVS 207
CL ++++ LG +I + GD I V+RI GG A R+G L GD+++ +NGV
Sbjct: 863 ACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVD 922
Query: 208 VEGLDPEQVIHILAMSRGTI 227
V + + +L + TI
Sbjct: 923 VTEARHDHAVSLLTAASPTI 942
Score = 38.1 bits (87), Expect = 0.025
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV-VPVS 235
I ++R+ G A R+G+ GDKL+EVNGV+++G + + + L + + +V
Sbjct: 758 IFISRVSEEGPAARAGVR-VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM 816
Query: 236 DPPVNSQQMVYVRAMTEYWPQE 257
P N+ + +R +Y P+E
Sbjct: 817 VEPENAVTITPLRPEDDYSPRE 838
Score = 30.0 bits (66), Expect = 6.8
Identities = 14/44 (31%), Positives = 26/44 (59%), Gaps = 1/44 (2%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
+ +++++ GLA RSG L GD+++ VNG V ++ + L
Sbjct: 1036 VFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 57.0 bits (136), Expect = 5e-08
Identities = 52/200 (26%), Positives = 85/200 (42%), Gaps = 23/200 (11%)
Query: 43 YSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKLVPATPHAQVLSYEVVELLRETP 102
Y D G+ + P +A +++ D L E L A H E VE LR
Sbjct: 751 YKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHH------EAVEALRGAG 804
Query: 103 TSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPL--------LPPLPDNIPESEEAMRI 154
T+ +++ R+ + P ++ + D+ P LP LP P +
Sbjct: 805 TAVQMRVWRERMVEPENAVTITP--LRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHV 862
Query: 155 VCLVKNQQPLGATIKRHE-----MTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVS 207
CL ++++ LG +I + GD I V+RI GG A R+G L GD+++ +NGV
Sbjct: 863 ACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVD 922
Query: 208 VEGLDPEQVIHILAMSRGTI 227
V + + +L + TI
Sbjct: 923 VTEARHDHAVSLLTAASPTI 942
Score = 38.1 bits (87), Expect = 0.025
Identities = 24/82 (29%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKV-VPVS 235
I ++R+ G A R+G+ GDKL+EVNGV+++G + + + L + + +V
Sbjct: 758 IFISRVSEEGPAARAGVR-VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM 816
Query: 236 DPPVNSQQMVYVRAMTEYWPQE 257
P N+ + +R +Y P+E
Sbjct: 817 VEPENAVTITPLRPEDDYSPRE 838
Score = 30.0 bits (66), Expect = 6.8
Identities = 14/44 (31%), Positives = 26/44 (59%), Gaps = 1/44 (2%)
Query: 177 ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL 220
+ +++++ GLA RSG L GD+++ VNG V ++ + L
Sbjct: 1036 VFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,263,004
Number of Sequences: 37866
Number of extensions: 1168112
Number of successful extensions: 5212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 4577
Number of HSP's gapped (non-prelim): 615
length of query: 637
length of database: 18,247,518
effective HSP length: 109
effective length of query: 528
effective length of database: 14,120,124
effective search space: 7455425472
effective search space used: 7455425472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.