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Search of human proteins with 145580592
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145580592 nesprin-3 [Homo sapiens]
(975 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145580592 nesprin-3 [Homo sapiens] 1924 0.0
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 285 1e-76
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 285 1e-76
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 97 1e-19
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 97 1e-19
gi|221316624 dystonin isoform 4 [Homo sapiens] 80 7e-15
gi|221316622 dystonin isoform 3 [Homo sapiens] 80 7e-15
gi|221316618 dystonin isoform 2 [Homo sapiens] 80 7e-15
gi|34577047 dystonin isoform 1 [Homo sapiens] 80 7e-15
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 80 7e-15
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 77 8e-14
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 77 1e-13
gi|33188443 microfilament and actin filament cross-linker protei... 75 4e-13
gi|33188445 microfilament and actin filament cross-linker protei... 75 4e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 73 1e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 73 1e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 73 1e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 73 1e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 73 1e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 73 1e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 73 1e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 73 1e-12
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 72 2e-12
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 72 2e-12
gi|55770834 centromere protein F [Homo sapiens] 67 6e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 66 2e-10
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 64 7e-10
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 64 7e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 9e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 61 4e-09
>gi|145580592 nesprin-3 [Homo sapiens]
Length = 975
Score = 1924 bits (4985), Expect = 0.0
Identities = 975/975 (100%), Positives = 975/975 (100%)
Query: 1 MTQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVR 60
MTQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVR
Sbjct: 1 MTQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVR 60
Query: 61 VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLL 120
VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLL
Sbjct: 61 VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLL 120
Query: 121 ARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL 180
ARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL
Sbjct: 121 ARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL 180
Query: 181 FNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVV 240
FNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVV
Sbjct: 181 FNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVV 240
Query: 241 EKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
EKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG
Sbjct: 241 EKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
Query: 301 ELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQ 360
ELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQ
Sbjct: 301 ELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQ 360
Query: 361 PAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 420
PAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI
Sbjct: 361 PAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 420
Query: 421 QEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLP 480
QEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLP
Sbjct: 421 QEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLP 480
Query: 481 QIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRK 540
QIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRK
Sbjct: 481 QIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRK 540
Query: 541 SKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLD 600
SKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLD
Sbjct: 541 SKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLD 600
Query: 601 LGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL 660
LGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL
Sbjct: 601 LGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL 660
Query: 661 RQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSP 720
RQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSP
Sbjct: 661 RQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSP 720
Query: 721 EGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLI 780
EGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLI
Sbjct: 721 EGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLI 780
Query: 781 NPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRT 840
NPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRT
Sbjct: 781 NPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRT 840
Query: 841 RKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSS 900
RKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSS
Sbjct: 841 RKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSS 900
Query: 901 PGEPTGFQKTRRWRGLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFA 960
PGEPTGFQKTRRWRGLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFA
Sbjct: 901 PGEPTGFQKTRRWRGLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFA 960
Query: 961 RSFTLMLRYNGPPPT 975
RSFTLMLRYNGPPPT
Sbjct: 961 RSFTLMLRYNGPPPT 975
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 285 bits (729), Expect = 1e-76
Identities = 193/751 (25%), Positives = 370/751 (49%), Gaps = 15/751 (1%)
Query: 4 QPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
Q + + +++ W+KA+QD+L ++T G + LE RL + + I ++ EG V++++
Sbjct: 2631 QEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM 2690
Query: 64 VLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARD 123
+ E L + + I +L+ +K W + ++ H S +E V W++Y+ ++
Sbjct: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2750
Query: 124 EFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
+ +W + + +E ++ Q GLKEK L H Q +L ++ L RL+ ++ L+ +
Sbjct: 2751 QLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK 2810
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
D S + AQ+ +K +++ + A++++ +E++ ++H Y V EF WL + E++
Sbjct: 2811 TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
Query: 244 NGCLGRNCKLPITQ-RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
+ + TQ +LS ++++ G L +E + V +NT+ G E + E+
Sbjct: 2871 HRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM 2930
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQ----QIKQLEAELSEFRMVLQRLAQEG 358
+ +R ++ + + L L+ EQ Q+ QLE L +F +L+ AQ+
Sbjct: 2931 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ- 2989
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
L T++E+V W + AL EPR + L++QL EL F +L S V
Sbjct: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
Query: 419 TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLHT 477
I+EY L +++++ L Q F++ +D Q W A+ +P ++ + T
Sbjct: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
L +I+ L ES + L M+ K +LL + +E+A + +V + D H++L
Sbjct: 3110 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3169
Query: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Q++S L++L Q KDF + EP+Q L + V DLP K+ + +LQ + EE
Sbjct: 3170 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE 3229
Query: 598 GLDLGAQMEAARPLVQE-------NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650
Q+ + Q+ + + +H++ QLSS + AL ++ V R + V EH
Sbjct: 3230 IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3289
Query: 651 CTFSHQLLELRQWIVVTTQKLEAH-RGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
FS + EL+ W+ L+++ + +S+ + E L++ EKE Q+ ++
Sbjct: 3290 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
+G V++ +SPEG +Q++L+ + + W +L
Sbjct: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASL 3380
Score = 105 bits (262), Expect = 2e-22
Identities = 128/640 (20%), Positives = 257/640 (40%), Gaps = 52/640 (8%)
Query: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
+ F +++ Q WM L + ++ L++R + E + ++ E +++ +++
Sbjct: 3290 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
Query: 67 MAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFY 126
E++L + P I +L+ +K W ++ C S++E W+ Y +F
Sbjct: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3409
Query: 127 RWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD 186
W M L L++K L A++L V + + LL+ + + A +
Sbjct: 3410 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVN-- 244
+D Q+R Y A++ +A++ V E++ R H+EYQ + F++WL EK++
Sbjct: 3470 QLELQDLQER----YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3525
Query: 245 GCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEE 304
L + T L LQ++ G+ L ++ VI + P +
Sbjct: 3526 SVLEGDAHTHET-TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAED-------- 3576
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+ LE LR W+ + RL +R + + +L +F+ V E L+ A +
Sbjct: 3577 --RALESLRQDWQAYQHRLS---ETRTQFNNVVNKLRLMEQKFQQV-----DEWLKTAEE 3626
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
+E+ A+ V+ + A+ +E++ H + YQ
Sbjct: 3627 KKWHEEVTAY--------------RDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3672
Query: 425 SLKVKSARLRNAAAVEL--WQHFQRPLQDLQLWKALAQRLLEVTAS---LPDLPSLHTFL 479
+L ++ E+ + + L W + + A+ D + L
Sbjct: 3673 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3732
Query: 480 PQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQR 539
+E L + + LL + K + + + A L +++ M L +++ +
Sbjct: 3733 KTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKE 3792
Query: 540 KSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGL 599
L+ L K+F + L + + + Q + + + +L K+AQLS+ + LQ+ L
Sbjct: 3793 HMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVL 3852
Query: 600 -------DLGAQMEAARPLVQENPNHQHKMDQLSSDFQAL 632
+ + EA LVQ+ + K+DQL SD+Q L
Sbjct: 3853 SHEPSVKSVREKGEALLELVQD-VTLKDKIDQLQSDYQDL 3891
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 8379 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8433
Query: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 8434 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8487
Query: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 8488 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8547
Query: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 8548 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8607
Query: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
E V Q + L G TS R + K L G ++
Sbjct: 8608 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8667
Query: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 8668 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 8726
Query: 954 TLANNFARSFTLMLRY-NGPPP 974
L+NNFARSF MLRY NGPPP
Sbjct: 8727 ALSNNFARSFHPMLRYTNGPPP 8748
Score = 71.2 bits (173), Expect = 4e-12
Identities = 175/953 (18%), Positives = 364/953 (38%), Gaps = 152/953 (15%)
Query: 8 DFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRM 67
++ R ++ + W+ Q++L +G E L + +++ EG+ ++ VL
Sbjct: 3503 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3562
Query: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
E ++ P L+ ++ W+ + H E R +F
Sbjct: 3563 REDVI---PSGIPQAEDRALESLRQDWQ------AYQHRLSE-----------TRTQFNN 3602
Query: 128 WFQKMMVTLEPHIELQLGLK---EKQWQLSHAQVLLHN--VDNQAVLLDRLLEEAASLFN 182
K+ + + ++ LK EK+W H +V + V+ +L+E+ + +
Sbjct: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKW---HEEVTAYRDEVEEVGARAQEILDES-HVNS 3658
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEK 242
R+G + ++ + Y A+ + +++ LE+ + EE ++ + + W + +
Sbjct: 3659 RMGCQAT------QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKN 3712
Query: 243 VNGCLGRNCKLPIT---QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
+ K+ ++L TL+ + KD +G L++ E+ ++ AE++
Sbjct: 3713 FKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLR 3772
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGL 359
E+ + + L++L + +E L L + + K L ++E++ +L + +
Sbjct: 3773 KEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKM 3832
Query: 360 QPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIAT 419
+ K A +Y + + + S EP
Sbjct: 3833 ELYEKK-------AQLSKYKSLQQTVLSHEP----------------------------- 3856
Query: 420 IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFL 479
VKS R + A +EL +QD+ L ++ ++ + DL S+
Sbjct: 3857 -------SVKSVREKGEALLEL-------VQDV----TLKDKIDQLQSDYQDLCSIG--- 3895
Query: 480 PQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQR 539
+A + E + ++ L LQ+K D LIG L + V ++ ++++
Sbjct: 3896 ---KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICST 3952
Query: 540 KSKL-QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDL-PGKQAQLSRLQGLQEE 597
++ QSL + + + + LQ+ Q + A +Q DL P Q LSR + +++
Sbjct: 3953 AQRMYQSLEHELQKHVSRQDTLQQ----CQAWLSA---VQPDLEPSPQPPLSRAEAIKQV 4005
Query: 598 GLDLGAQMEAARP----LVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
A E AR L + + D Q ++++E + + + Q
Sbjct: 4006 -KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4064
Query: 654 SHQLLELRQWIVV-----TTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL-SLV 707
H EL WI + Q ++ E A++ ++ + V + K+A + +++
Sbjct: 4065 KHLKSEL--WIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4122
Query: 708 EAQGWLVMEKSSPEGAAV--VQEELRELAESWRALRLLEESLLSLIRNWH--LQRMEVDS 763
E L ++ SPE + + ++ +L L L E L R++H + +EV
Sbjct: 4123 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4182
Query: 764 GKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSK 823
K +N+ +S + + ++ A LQE + + ED + + L +++ +
Sbjct: 4183 EKFTTEWDNLARSDAESTAVH-LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4241
Query: 824 LV-------------------RIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLR 864
LV R I + + E+L +S+ QEL E Q L+
Sbjct: 4242 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301
Query: 865 LGPARGTSDEL--------EDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQK 909
P + L +L + ML KS +KD+ ++ E QK
Sbjct: 4302 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4354
Score = 68.9 bits (167), Expect = 2e-11
Identities = 115/641 (17%), Positives = 250/641 (39%), Gaps = 55/641 (8%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKA 206
++ +W S + + ++ + LD + L + + +K +++ VK
Sbjct: 2126 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL---------KKIHSSDFSLVKT 2176
Query: 207 KAQKRVDLLEQVAREHEEYQAGVD-EFQLW--LKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
+ VD V+ + EE + +W + + +++ G NC + + +S L
Sbjct: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW-SNNCVPQMAENISNLD 2235
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERL 323
+ R EE L+ E + L ++ +L+E+ K LE L E + +
Sbjct: 2236 NHL----RAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQFIEADLM 2289
Query: 324 RGLLRSRGAWEQQ---IKQLEAELSEFRMVLQRLA------QEGLQPAAKAGTEDELVAH 374
+ L ++ E +K A+ ++ + + +E L A+ T + L
Sbjct: 2290 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEAL--- 2346
Query: 375 WRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLKVKSAR 432
++ + L S++ + Q L L H+ L+ L ++ I++++++ ++
Sbjct: 2347 -KKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSK 2405
Query: 433 LRNAAAVELWQHFQRPLQDLQLW----KALAQRLLEVTASLPDLPSLHTFLPQIEAALME 488
+ + L +HF +Q+ Q W KA A+ + T D L L ++ L
Sbjct: 2406 TQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG---DSKVLEAKLHDLQNILDS 2462
Query: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
S + L + + L ++ +++ EQ+ + + L+ K LQ +
Sbjct: 2463 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2522
Query: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEK--GLQRDLPGKQAQLSRLQGLQEEGLDLGAQME 606
+ F L + +++ R E ++ +P K+ ++ +++ E L ++
Sbjct: 2523 ELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLD 2582
Query: 607 AARPLVQENPNHQH-------KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Q H QL + Q L R ++ + C+ ++QEH L
Sbjct: 2583 KLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQS 2642
Query: 660 LRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKS 718
+ W+ +L G D E + ++ + ++ E E +L++ +G + S
Sbjct: 2643 MWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSS 2702
Query: 719 SPEGAAVVQEELRELAESWRALRL----LEESLLSLIRNWH 755
+ EG V+Q +L L E W + + +L S+I W+
Sbjct: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
Score = 60.5 bits (145), Expect = 8e-09
Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)
Query: 143 QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182
QLG K WQ +L V + LL+ LLE + N
Sbjct: 6924 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 6978
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223
RIGD + ++A K + D +KAK +K V+ +EQ RE
Sbjct: 6979 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 7037
Query: 224 EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257
+ A +D + ++ LK+V++ K+N L +
Sbjct: 7038 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7097
Query: 258 RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
++ LQ++ D + E SL+ + +++ P E +T L+E+ + L E
Sbjct: 7098 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 7154
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
E E+L+ W Q+ K + + + E L+ A D+ VA W +
Sbjct: 7155 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7213
Query: 378 YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429
D L+ +K+ + F H L + + S + IQ Q SL
Sbjct: 7214 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7261
Query: 430 SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478
L A A V ++ F + L+ L+ W A+ +L+ + DL ++
Sbjct: 7262 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 7321
Query: 479 LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538
+ +++ +++ S + L L + + + +E ++++ R L+ + +
Sbjct: 7322 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 7375
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596
R SKLQS L QH+ F L++ ++ VQ E+ L ++ G L Q E
Sbjct: 7376 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7429
Query: 597 -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645
+ + Q + V + K+ LS+ +Q + R +
Sbjct: 7430 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7489
Query: 646 SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700
+++ + +LR+W+V + + G P + F+ + +F EK
Sbjct: 7490 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 7546
Query: 701 -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755
+ + VEA L++ S AA +Q EL E+ E W+ ++RL E+ L L+++W
Sbjct: 7547 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 7605
Query: 756 LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809
+ + + T S L + + + + R L+ GS +D +QL
Sbjct: 7606 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7660
Score = 58.5 bits (140), Expect = 3e-08
Identities = 142/799 (17%), Positives = 309/799 (38%), Gaps = 75/799 (9%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F S+++ Q W + + + + G LEA+L + + I +G+ ++D V +
Sbjct: 2418 FSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEG 2477
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR- 127
+ L A K + + + I EE ++ C + + SE D+ +
Sbjct: 2478 QTLYAHL---SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Query: 128 --WFQKM--MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
W +M E E + + EK+ ++ ++ L + LD+L + L
Sbjct: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
+ ++ + + ++++ + +EHE + + W+KA+ +++
Sbjct: 2595 GHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRL 2654
Query: 244 ---NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
LG K + +RLS +QDI GE L + +R+++ G I
Sbjct: 2655 ACAESTLG--SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT 2712
Query: 301 ELEEMRKV--------------LEKLRALWEEEEERLRGLLRSRGAWEQQIK---QLEAE 343
+LE +++V LE + + W + ER L + + +Q+I+ Q +
Sbjct: 2713 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2772
Query: 344 LSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI 403
L E ++L L Q L A ED A R + +R E + AQ +EL
Sbjct: 2773 LKEKFVLLDHL-QSILSEA-----EDHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELK 2825
Query: 404 VFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLL 463
+++ ++ + ++E VK + A E ++L W ++
Sbjct: 2826 TQFNDIMTVAKEKMRKVEEI----VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG--- 2878
Query: 464 EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVA 523
+ +A+ L + + E SR++ L ++K++ G E ++ +
Sbjct: 2879 DSSATQKKLSKIKELIDSREIGASRLSRVESLAP--EVKQNTTAS--GCELMHTEMQALR 2934
Query: 524 GSMRDRDLLHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQR 579
+ + +S+ Q +S L++L++Q ++F L++ L ++
Sbjct: 2935 ADWKQWE---DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT 2991
Query: 580 DLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDL 639
L GK + +G ++ ++ A P ++ + +++ + S D + L
Sbjct: 2992 LLEGKNTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGL 3050
Query: 640 VDR----CRQSVQEHCTFSHQLLELR---------QWIV---VTTQKLEAHRGEAGPGDA 683
+ C Q+ + C Q+L+ R QW+V +TT K +
Sbjct: 3051 IKEYNCLCLQA-SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAK--CFDIPQNISEV 3107
Query: 684 ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLL 743
+ + + ++E + +L+++ ++G L+ + E A +Q ++ E W+
Sbjct: 3108 STSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3167
Query: 744 EESLLSLIRNWHLQRMEVD 762
S + N +Q + +
Sbjct: 3168 LHQKESALENLKIQMKDFE 3186
Score = 58.2 bits (139), Expect = 4e-08
Identities = 143/777 (18%), Positives = 288/777 (37%), Gaps = 92/777 (11%)
Query: 12 SVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEAL 71
+V + W+ + +++L + G +A + +L + +++ G R+ V +A +
Sbjct: 2855 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2914
Query: 72 LACCPGDQKPGILARLKDIKA---QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ ++ ++A QWE++V C + S+ L+ EF
Sbjct: 2915 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEFSGQ 2968
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAV--------LLDRL------L 174
++ LE Q K W + N D + V +LD L
Sbjct: 2969 VAQLEQALE-----QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Query: 175 EEAASLFNRI----GDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
E+ S N + D S + EY+ + +A K EQ+ ++ ++
Sbjct: 3024 EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRKAFR 3081
Query: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
+FQ WL N K+ + Q+I++ ++ E L E G +
Sbjct: 3082 DFQQWLV------------NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3129
Query: 291 SPLGAEKITGEL---EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEF 347
L ++ L E+ + + K+ A +E+ + L + E ++ L+ ++ +F
Sbjct: 3130 MMLSKGELLSTLLTKEKAKGIQAKVTAA-KEDWKNFHSNLHQK---ESALENLKIQMKDF 3185
Query: 348 RMVLQRLAQEGLQPAAKAGTED-----ELVAHWRRYSATRAALAS---EEPRVDRLQAQL 399
+ + + Q+ L K E +L A R ++ L EP+++RL+ +
Sbjct: 3186 EVSAEPI-QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA 3244
Query: 400 KELIV-------FPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDL 452
++L F H + LS +A K K +RL A F +++L
Sbjct: 3245 QQLWEGQAASKSFRHRVSQLSSQYLALSN---LTKEKVSRLDRIVAEH--NQFSLGIKEL 3299
Query: 453 QLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Q W A +L+ D L + ++EA L + + M+ + + ++
Sbjct: 3300 QDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3359
Query: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
E + +Q+ L ++ ++ KS+L+ L++ + + ++ +
Sbjct: 3360 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3419
Query: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
+ +L K L + + L EE L + +E H Q ++ L
Sbjct: 3420 NESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQER 3479
Query: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEA 688
++A+Q ++ V + + V+ H + L W+ +KL+ + GDA + E
Sbjct: 3480 YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY--SVLEGDAHTHET 3537
Query: 689 EFERLVAEFPEKEAQLSLVEAQGWL-----VMEKSSPEGAAVVQEE-LRELAESWRA 739
L +E Q+ E Q L E P G ++ L L + W+A
Sbjct: 3538 TLRDL------QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA 3588
Score = 52.0 bits (123), Expect = 3e-06
Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266
+A+ R+ L Q A EEY ++ W++ +G + N + ++ Q +
Sbjct: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
Query: 267 KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326
++ + LE + E+ + TS EK++ ++ E+ + E+LR + + + L+
Sbjct: 5503 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5559
Query: 327 LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
+ +E ++K+L+A L + + L P + E ++H + + +L
Sbjct: 5560 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 5612
Query: 387 SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440
+ V Q+ L+ P ++ PL + + +E L+ ++ + AA V+
Sbjct: 5613 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 5668
Query: 441 LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Q+ Q QL + + + + + ++ L + + E + +E + L
Sbjct: 5669 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 5728
Query: 501 LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
K +L + AT LL +V G + L LL S S++
Sbjct: 5729 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 5780
Query: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601
LL E+G ++ A ++ Q L E L
Sbjct: 5781 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5839
Query: 602 GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
A++ + QE P + D Q +L++++ ++++ E + +
Sbjct: 5840 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 5899
Query: 660 LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712
Q I + +E E+ PG ESQ AE + L+ E E Q SL E
Sbjct: 5900 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 5956
Query: 713 LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757
LV E ++ P +Q L LAE +R LLEE L + +
Sbjct: 5957 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 6016
Query: 758 -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813
R E D + + L P +P+ + N+L E E S+
Sbjct: 6017 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 6071
Query: 814 GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872
L V N L ++ + T ++ KL+ L+ + E Q L + L + +GT+
Sbjct: 6072 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 6123
Query: 873 DELED 877
E E+
Sbjct: 6124 QEKEE 6128
Score = 48.1 bits (113), Expect = 4e-05
Identities = 99/619 (15%), Positives = 243/619 (39%), Gaps = 97/619 (15%)
Query: 171 DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
+R L++ A L E Q++M + + + ++ ++Q+ +H+EY G++
Sbjct: 6521 ERALQDLADLL---------ETGQEKMAGDQKIIVSSKEE----IQQLLDKHKEYFQGLE 6567
Query: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
+ + + K+ + T+ ++ + K + LE + E + + +
Sbjct: 6568 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6627
Query: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERL-------RGLLRSRGAWEQQIKQ---- 339
++++ +LE + + + L EE E+RL + L S ++ ++ Q
Sbjct: 6628 -----QELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 6681
Query: 340 -----LEAELSEFRMVLQRLAQEGLQPAAKAGTE----DELVAHWRRYSATRAALASE-E 389
+ S+ L +L + L K E + ++ HW RY + A L +
Sbjct: 6682 GKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6741
Query: 390 PRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPL 449
DRL+ ++ + P L+ + D + A ++ + + +S+ + + + +
Sbjct: 6742 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6801
Query: 450 QDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSR-LKELLTMLQLKKDLLIG 508
L L++ + T L ++P++ L Q++ + S + E+++ + L ++++
Sbjct: 6802 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-- 6859
Query: 509 IFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ 568
+D D + NS+ + A E LQ+
Sbjct: 6860 -----------------QKDEDNIKNSI---------------GYKAIHEYLQKY----- 6882
Query: 569 VRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ-MEAARPLVQENPNHQHKMDQLSS 627
KG + D+ KQ + + + L + +Q +E+ R + + ++ ++
Sbjct: 6883 ------KGFKIDINCKQLTVDFVN---QSVLQISSQDVESKR---SDKTDFAEQLGAMNK 6930
Query: 628 DFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQE 687
+Q LQ + + + ++ + + + L+ W ++L+ ++
Sbjct: 6931 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAL 6990
Query: 688 AEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRAL----RLL 743
+ + L KE ++ +E G +++ + +++V LREL ++W L L
Sbjct: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
Query: 744 EESLLSLIRNWHLQRMEVD 762
+ L S++ W ++ D
Sbjct: 7051 KILLKSVLDQWSSHKVAFD 7069
Score = 47.0 bits (110), Expect = 9e-05
Identities = 73/378 (19%), Positives = 145/378 (38%), Gaps = 60/378 (15%)
Query: 90 IKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLE-PHIELQLGLKE 148
++ Q+E+ + + +E + HW F W ++ P +++ +
Sbjct: 1639 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1698
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK- 207
+ +L Q L + V +QA +LL+ SLF+ +D K MK + + +
Sbjct: 1699 VEGELQLIQALQNEVVSQASFYSKLLQLKESLFS-----VASKDDVKMMKLHLEQLDERW 1753
Query: 208 ------AQKRVDLLEQVAREHEEYQAGVDEFQLWL------------------------- 236
KR++ L+ V EH+++ + F +W+
Sbjct: 1754 RDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRH 1813
Query: 237 ----------KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKD-FPRGEESLETLEEQSAG 285
K ++ + G L + L + L LQ A+D F EE+ + +E +
Sbjct: 1814 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA 1873
Query: 286 VIRNTSPLGAE-KITGELEEMRKVLEKLRALWEEE----EERLRGLLRSRGAWEQQIKQL 340
+ L + ++G L ++R+ +E ++ + E E+ L L++ A E L
Sbjct: 1874 LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSL 1933
Query: 341 EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRL----Q 396
+ LS+ + L+ + E Q + T D+L R SE + L Q
Sbjct: 1934 DGILSKAQYHLKIGSSE--QRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ 1991
Query: 397 AQLKELIVFPHNLKPLSD 414
Q +EL+ +++ +D
Sbjct: 1992 DQKEELLKSIEDIEERTD 2009
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/344 (17%), Positives = 131/344 (38%), Gaps = 14/344 (4%)
Query: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 7820 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 7877
Query: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 7878 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 7937
Query: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 7938 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 7997
Query: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 7998 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 8056
Query: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 8057 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 8115
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAE 343
EL+E+R+ +++ E ++L L + ++LE E
Sbjct: 8116 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159
Score = 46.6 bits (109), Expect = 1e-04
Identities = 94/452 (20%), Positives = 169/452 (37%), Gaps = 49/452 (10%)
Query: 93 QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKM---MVTLEPHIELQLGLKEK 149
+W+ +T R++ E+ ARD W +M + +E E + K K
Sbjct: 8017 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK 8076
Query: 150 QWQLSHAQVLL-HNVDNQAVLL-DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK 207
Q + ++ L HN Q + ++L+E++ L I + +DE +R E +
Sbjct: 8077 QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE--LRRYCQEVFGRVER 8134
Query: 208 AQKRVDLLEQVAREHE--------EYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
K++ L EH+ E A + + ++ ++ N L + Q L
Sbjct: 8135 YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8194
Query: 260 STLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRK------------ 307
+ + +D P +S+ + + R+ + + E EE +
Sbjct: 8195 RSERS-GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 8253
Query: 308 ----VLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAA 363
+ E A + E ++ A E QI+QL L + R +Q+ +
Sbjct: 8254 SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRS 8310
Query: 364 KAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE----LIVFPHNLKPLSDSVIAT 419
K T EL ++ Y +S V RL+ +LKE L F NL
Sbjct: 8311 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV-NLHSTETQTAGV 8369
Query: 420 IQEYQSLKVK--SARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT 477
I ++ L+ + S LR ++ WQ F L + W + LE L L T
Sbjct: 8370 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL----ELST 8425
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
+ IE ++ +LKEL + +K +++ I
Sbjct: 8426 DIQTIE---LQIKKLKELQKAVDHRKAIILSI 8454
Score = 45.8 bits (107), Expect = 2e-04
Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)
Query: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61
+ F +S+E +AW+ ++ LQ D + + ++ R+ E + K + P+
Sbjct: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
Query: 62 DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114
+L R+ P + K + R++++ W + T S+++ L
Sbjct: 7344 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 7393
Query: 115 ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
W E+L+ + QK+ V + + + L +++ +L A++ ++++D
Sbjct: 7394 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 7446
Query: 172 --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224
RLLE+ VD+ + +K ++ V +AQ+R +++ R+ +
Sbjct: 7447 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7496
Query: 225 YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281
Y+ ++ + WL V LG + +P+ Q + ++ K F R + S E
Sbjct: 7497 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7555
Query: 282 QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341
++ + + EL E+++ + EE++++L LL+ WE+ K +
Sbjct: 7556 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 7612
Query: 342 AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401
L + R ++L+Q + +EL A R A+ S + +L + LK+
Sbjct: 7613 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 7665
Query: 402 LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456
+ + ++ L++ V ++++ L ++ R + + W F ++L W
Sbjct: 7666 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 7724
Query: 457 ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515
L Q +V+ + L + + +++ E + +E LQ + L + +A
Sbjct: 7725 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7781
Query: 516 TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574
+ +E G + DR L + + R KL+ L + L+ L + +
Sbjct: 7782 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 7838
Query: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632
K + D + +L QE D+ ++ H D ++D + ++
Sbjct: 7839 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 7898
Query: 633 QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678
Q++ +L R C S++ F W+ ++++ A +
Sbjct: 7899 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 7957
Query: 679 GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736
G A+ + +FE + E QL L+ Q + ++ + A +++ + E +
Sbjct: 7958 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8017
Query: 737 WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768
W L+ S+L ++++ QR E ++ + +
Sbjct: 8018 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 8049
Score = 45.4 bits (106), Expect = 3e-04
Identities = 82/429 (19%), Positives = 166/429 (38%), Gaps = 64/429 (14%)
Query: 266 AKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE-------- 317
A + P G ++ + L++Q+ + +K+ LEE K +E ++ W+
Sbjct: 1410 ASEIPLGPQNKQLLQQQAKSIKEQV-----KKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1464
Query: 318 ------EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
E+E+ L L S A + QI Q++ + E L + GL+ A++ +
Sbjct: 1465 LSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV--GLEEEAQSFAQFVT 1522
Query: 372 VAHWRRYSA--TRAALASEEPRVDR------LQAQLKELIVFPHNLKPLSDSVIATIQEY 423
R A T+ EE R + L + F NL+ + SV + ++
Sbjct: 1523 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSV-SEFEDK 1581
Query: 424 QSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
++ +K ++A E ++ Q + Q ++L+ + +AS
Sbjct: 1582 LAVPIKIC----SSATETYKVLQEHMDLCQALESLSSAITAFSASA-------------R 1624
Query: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
+ S ++E + Q +D+L +ER TAL +A R L + L +
Sbjct: 1625 KVVNRDSCVQEAAALQQQYEDILRR--AKERQTALENLLAHWQRLEKELSSFLTWLERGE 1682
Query: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGA 603
+ D A ++ +L Q + LQ ++ + + S+L L+E + +
Sbjct: 1683 AKASSPEMDISADRVKVEGEL-------QLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1735
Query: 604 QMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQW 663
+ + + ++QL ++ L + + ++ + V EH F LL W
Sbjct: 1736 KDDVKMMKLH--------LEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1787
Query: 664 IVVTTQKLE 672
I + +L+
Sbjct: 1788 IKLFLSELQ 1796
Score = 43.9 bits (102), Expect = 7e-04
Identities = 127/632 (20%), Positives = 245/632 (38%), Gaps = 101/632 (15%)
Query: 115 WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK-EKQWQLSHAQVLLHNVDNQAVLLDRL 173
W +Y AR+E L L+ E + +LS + L+ V++ + L
Sbjct: 5032 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
Query: 174 LEEAASLFNRIGDPSVDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
EE AS + G+ + + M + ++A AQ + +LE E + V
Sbjct: 5092 -EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVK 5150
Query: 231 EFQLWLKAVVEKVNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRN 289
+ + + +K+ G K + L + + + +L L +Q+ ++++
Sbjct: 5151 KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQD 5210
Query: 290 TS-------PLGAEKITGELEEMRKVLEKLRALWE------EEEERLRGLLRSRGAWEQQ 336
+ P ++IT + + EK++ + ++ E + + S W Q+
Sbjct: 5211 GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5270
Query: 337 IKQ--------LEAELSEFRMVLQRLA--QEGLQPAAKAGTEDELVAHW---RRYSATRA 383
K+ ++A+L E +++L ++ ++ A+ E L + S A
Sbjct: 5271 TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLA 5330
Query: 384 ALASEEPRVDRLQAQLKE---------------------LIVFPHNLKPLSDSVIATIQE 422
+A + D++Q ++KE L LK +D+V+ Q
Sbjct: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV---QA 5387
Query: 423 YQSLKVKSARLR--NAAAVELWQHFQRPL-QDLQLWKALAQRLLEVTA----SLPDLPSL 475
KV L N+ +EL Q+ L Q+ QL K LA+++ ++T ++ +
Sbjct: 5388 KTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5447
Query: 476 HTFLPQIEAALMESSRLKEL-LTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHN 534
+ L Q + L E + + EL L ++ K L G A+ L EQ +LH
Sbjct: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY--------ILHQ 5499
Query: 535 SLLQRKSKLQSLLA--------------------QHKDFGAAFEPLQRKLLDLQVRVQAE 574
+LL+ ++ S L Q + G E L++ + ++R+Q
Sbjct: 5500 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 5556
Query: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH-QH---KMDQLSSDFQ 630
+ +D+ +A+L +LQ E+ E R ++E +H QH +M+ L Q
Sbjct: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ 5616
Query: 631 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQ 662
A+Q L R + V H L L++
Sbjct: 5617 AVQLCQSAL--RIPEDVVASLPLCHAALRLQE 5646
Score = 40.4 bits (93), Expect = 0.008
Identities = 87/448 (19%), Positives = 187/448 (41%), Gaps = 40/448 (8%)
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV-----DEFQLWLKA 238
+G+P+++ DAQ E + +A +E++A E +E G+ E L L
Sbjct: 5275 LGNPTIEIDAQLE---ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5331
Query: 239 VVE--KVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLET----LEEQSAGVI--RNT 290
V K+ + K + Q +T Q++++ + + L T L+ ++ V+ +
Sbjct: 5332 VALDLKIRDQIQDKIK-EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
Query: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAW----EQQIKQLEAELSE 346
+ E++ G ++ ++ ++ E+ + + L + G +Q I+Q E LS+
Sbjct: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5450
Query: 347 FRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALASEEPRVDRLQAQLK 400
L + E L+ K + +++AH W S R + ++ +
Sbjct: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
Query: 401 ELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
EL L+ L+ SV T Q+ L ++ LR + L Q+ Q +D++ ++A
Sbjct: 5511 ELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QNLQDAAKDMKKFEA 5568
Query: 458 LAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
++L + T + P++ SL L + L E LK + +QL + L
Sbjct: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP 5628
Query: 510 FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569
+ L + L ++ +Q+ + +Q+ + Q++ + + LQ+ +
Sbjct: 5629 EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR 5688
Query: 570 RVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
++ + ++ QAQ+SR + L ++
Sbjct: 5689 EIEDKPVATSNIQELQAQISRHEELAQK 5716
Score = 38.5 bits (88), Expect = 0.031
Identities = 94/549 (17%), Positives = 221/549 (40%), Gaps = 65/549 (11%)
Query: 101 MTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL 160
+T C SR+ + ++ W +++ L + L L L++ Q ++ Q+
Sbjct: 4805 VTECESRM----VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
Query: 161 HNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMKAEYD-----AVKAKAQKRVDL 214
V + +++ L + F + + S D + +E D A++ + ++
Sbjct: 4861 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
Q R ++ +QA D WL+ E + L N L + L+ + F ++
Sbjct: 4921 YSQCQRYYQVFQAAND----WLEDAQELLQ--LAGN-GLDVESAEENLKSHMEFFSTEDQ 4973
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLE-KLRALWEEEEERLRGLLRSRGAW 333
LEE + ++ PL +LE+ LE + + + + ++ L R W
Sbjct: 4974 FHSNLEELHS-LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5032
Query: 334 EQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVD 393
K E + ++L++ L + + +E ++ + A + + S ++
Sbjct: 5033 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE---HKALVSVVNSFHEKIV 5089
Query: 394 RLQAQLKELIVFPHNLKPLSDSVIATI-QEYQSLKVKSARLRNAAAVELWQHFQRPLQD- 451
L+ + +L K +D+ AT+ + ++ + RLR A Q ++ L+D
Sbjct: 5090 ALEEKASQLE------KTGNDASKATLSRSMTTVWQRWTRLRAVA-----QDQEKILEDA 5138
Query: 452 LQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
+ W ++ + T + L ++ + E + ELLT+L+ ++ +
Sbjct: 5139 VDEWTGFNNKVKKATEMIDQLQD------KLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
Query: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Q+ A +L Q SM L + + L+ + +Q + L++Q +V
Sbjct: 5193 QQSALGMLRQQTLSM-----LQDGAAPTPGEEPPLMQE-------ITAMQDRCLNMQEKV 5240
Query: 572 QAE-KGLQRDLPGKQAQLSRLQGLQ-----------EEGLDLGAQMEAARPLVQENPNHQ 619
+ K ++++L ++ +++ ++ +++ AQ+E + L+ E NH+
Sbjct: 5241 KTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHR 5300
Query: 620 HKMDQLSSD 628
+++++ +
Sbjct: 5301 QNIEKMAEE 5309
Score = 33.9 bits (76), Expect = 0.76
Identities = 123/705 (17%), Positives = 259/705 (36%), Gaps = 79/705 (11%)
Query: 78 DQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ--KMMVT 135
++ ++ + + AQW + S +E V +W Y W + + M+
Sbjct: 585 EEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN 644
Query: 136 LEPHIELQLGLKEKQWQLSHAQV------LLHNVDNQAVLLDRLLEEAASLFNRIGDPSV 189
+ + W H + L+ D ++ R L++ L N
Sbjct: 645 QSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDE---MVSRDLKQQLLLLN------- 694
Query: 190 DEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGR 249
R + + VK AQ D ++++ +E+ + + F + +
Sbjct: 695 -----GRWRELFMEVKQYAQ--ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFM 747
Query: 250 NCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVL 309
N KL I L+DI + P + + + + + + + + +++ + ++++ L
Sbjct: 748 NVKLLI----QDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQL 803
Query: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
K++ + + LL E+Q+ L + ++ L +E A
Sbjct: 804 TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 863
Query: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLK 427
EL+A T + V + L F + ++D +A +QS+
Sbjct: 864 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA----FQSMV 919
Query: 428 VKSARLRNAAAV--ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT-FLPQIEA 484
K+ + L + F+ +L+ +AQ LE +L HT F Q++
Sbjct: 920 KKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD- 978
Query: 485 ALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
+ +L D L I ++ L E V + L L+
Sbjct: 979 --------QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLS----------RLQGL 594
+ +++ F A+ E R LD + ++ ++G ++ + + S RLQ +
Sbjct: 1031 IDVEKNR-FLASVEEC-RTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI 1088
Query: 595 QEEGLDLGAQMEAARPLVQENPNHQH-KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
+E + L R V++ P H + +L + + R L + D+ + +
Sbjct: 1089 EELCVKL-----PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD-------Y 1136
Query: 654 SHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEF----PEKEAQLSLVEA 709
+ + E WI +L+ +GEA + E +R V E ++ LS +++
Sbjct: 1137 TSRFSEFSSWISTNETQLKGIKGEA---IDTANHGEVKRAVEEIRNGVTKRGETLSWLKS 1193
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNW 754
+ ++ E SS A +EL +L+ S++AL L + ++ N+
Sbjct: 1194 RLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238
Score = 33.1 bits (74), Expect = 1.3
Identities = 30/163 (18%), Positives = 72/163 (44%), Gaps = 1/163 (0%)
Query: 195 KRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK-AVVEKVNGCLGRNCKL 253
+ +++ YD+V K R+ LE+ + ++ D+ WLK A + N
Sbjct: 4466 QELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESS 4525
Query: 254 PITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLR 313
+ +L+ Q+I + P E L TL+ ++ + + + ++ +L + + +
Sbjct: 4526 ELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIV 4585
Query: 314 ALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
AL +++ +++ + +R + I+ LSE R+++
Sbjct: 4586 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSK 4628
Score = 32.0 bits (71), Expect = 2.9
Identities = 118/640 (18%), Positives = 229/640 (35%), Gaps = 82/640 (12%)
Query: 85 ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQL 144
++L + W M+ R+E + HW+ Y + W Q LE + +
Sbjct: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
Query: 145 GL-KEKQWQLSHAQVLLH---NVDNQAVLLDRLLEEAASLFN-RIGDPSVDEDAQKRMKA 199
+ +E + H L VD Q+ L +L L + D + R+ +
Sbjct: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 6815
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW---LKAVVEK----VNGCLGRNCK 252
++ + + L Q+ + + + E W ++ V++K + +G
Sbjct: 6816 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
Query: 253 LPITQRLS------TLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMR 306
Q+ + + DF +S+ + Q R+ AE +L M
Sbjct: 6876 HEYLQKYKGFKIDINCKQLTVDFV--NQSVLQISSQDVESKRSDKTDFAE----QLGAMN 6929
Query: 307 KVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAG 366
K + L+ L E+ + L GLL S +E ++ L+ L++ + G Q + +
Sbjct: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNA 6989
Query: 367 TEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSL 426
+D + ++E V++++ L + + + +S V++T++E
Sbjct: 6990 LKD--------CQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVMSTLRELGQT 7039
Query: 427 ------KVKSARLRNAAAVELW-----------QHFQRPLQDLQLWKALAQRLLEVTASL 469
V ++ + ++ W + L ++ L L V +
Sbjct: 7040 WANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV 7099
Query: 470 PDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDR 529
+L +L L + E +L + + QL K+ + E T L++V +MR
Sbjct: 7100 DNLQNLQDDLEKQERSLQKFGSITN-----QLLKECHPPV--TETLTNTLKEV--NMRWN 7150
Query: 530 DLLHN--SLLQRKSKLQSLLAQHKDFG---AAFEPLQRKLLDLQVRVQAEKGLQRD---- 580
+LL LQ L L ++KD+ A+ Q + ++ K + D
Sbjct: 7151 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT 7210
Query: 581 --------LPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQAL 632
L G L L E G L Q++A+ Q LS AL
Sbjct: 7211 WIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-----IQSDQLSLSQHLCAL 7265
Query: 633 QRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
+++L + V ++ TF+ L L WIV + L+
Sbjct: 7266 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ 7305
Score = 30.8 bits (68), Expect = 6.5
Identities = 82/380 (21%), Positives = 150/380 (39%), Gaps = 66/380 (17%)
Query: 257 QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE------------KITGELEE 304
QR+S L+D + E+ + LE Q V S + E + G L++
Sbjct: 4697 QRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQD 4756
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
VL+++ E+ L L A+E+ Q+++ E +++ + +
Sbjct: 4757 SGIVLKRVTIHLEDLAPHLDPL-----AYEKARHQIQSWQGELKLLTSAIGE-------- 4803
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
T E + + + ++ + R++A+L + NL+ + + I IQ +Q
Sbjct: 4804 --TVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE-IRKIQIHQ 4860
Query: 425 SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLP-SLHTFLPQIE 483
S R+ NA + + + F + + ++ L A L +L + L +
Sbjct: 4861 EEVQSSLRIMNALSHKEKEKFTKAKE------LISADLEHSLAELSELDGDIQEALRTRQ 4914
Query: 484 AALME-SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRD-------------- 528
A L E S+ + + Q D L E A LL Q+AG+ D
Sbjct: 4915 ATLTEIYSQCQRYYQVFQAANDWL------EDAQELL-QLAGNGLDVESAEENLKSHMEF 4967
Query: 529 ---RDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQ---AEKGLQRDLP 582
D H++L + S + +L K G E L++K+ L++R Q + G Q DL
Sbjct: 4968 FSTEDQFHSNLEELHSLVATLDPLIKPTGK--EDLEQKVASLELRSQRMSRDSGAQVDLL 5025
Query: 583 GK-QAQLSRLQGLQEEGLDL 601
+ AQ Q +EE ++L
Sbjct: 5026 QRCTAQWHDYQKAREEVIEL 5045
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 285 bits (729), Expect = 1e-76
Identities = 193/751 (25%), Positives = 370/751 (49%), Gaps = 15/751 (1%)
Query: 4 QPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
Q + + +++ W+KA+QD+L ++T G + LE RL + + I ++ EG V++++
Sbjct: 2624 QEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM 2683
Query: 64 VLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARD 123
+ E L + + I +L+ +K W + ++ H S +E V W++Y+ ++
Sbjct: 2684 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2743
Query: 124 EFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
+ +W + + +E ++ Q GLKEK L H Q +L ++ L RL+ ++ L+ +
Sbjct: 2744 QLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK 2803
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
D S + AQ+ +K +++ + A++++ +E++ ++H Y V EF WL + E++
Sbjct: 2804 TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
Query: 244 NGCLGRNCKLPITQ-RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
+ + TQ +LS ++++ G L +E + V +NT+ G E + E+
Sbjct: 2864 HRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM 2923
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQ----QIKQLEAELSEFRMVLQRLAQEG 358
+ +R ++ + + L L+ EQ Q+ QLE L +F +L+ AQ+
Sbjct: 2924 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ- 2982
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
L T++E+V W + AL EPR + L++QL EL F +L S V
Sbjct: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
Query: 419 TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLHT 477
I+EY L +++++ L Q F++ +D Q W A+ +P ++ + T
Sbjct: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
L +I+ L ES + L M+ K +LL + +E+A + +V + D H++L
Sbjct: 3103 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3162
Query: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Q++S L++L Q KDF + EP+Q L + V DLP K+ + +LQ + EE
Sbjct: 3163 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE 3222
Query: 598 GLDLGAQMEAARPLVQE-------NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650
Q+ + Q+ + + +H++ QLSS + AL ++ V R + V EH
Sbjct: 3223 IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3282
Query: 651 CTFSHQLLELRQWIVVTTQKLEAH-RGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
FS + EL+ W+ L+++ + +S+ + E L++ EKE Q+ ++
Sbjct: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
+G V++ +SPEG +Q++L+ + + W +L
Sbjct: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASL 3373
Score = 118 bits (296), Expect = 2e-26
Identities = 137/687 (19%), Positives = 285/687 (41%), Gaps = 42/687 (6%)
Query: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
+ F +++ Q WM L + ++ L++R + E + ++ E +++ +++
Sbjct: 3283 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3342
Query: 67 MAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFY 126
E++L + P I +L+ +K W ++ C S++E W+ Y +F
Sbjct: 3343 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3402
Query: 127 RWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD 186
W M L L++K L A++L V + + LL+ + + A +
Sbjct: 3403 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3462
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVN-- 244
+D Q+R Y A++ +A++ V E++ R H+EYQ + F++WL EK++
Sbjct: 3463 QLELQDLQER----YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3518
Query: 245 GCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEE 304
L + T L LQ++ G+ L ++ VI + P +
Sbjct: 3519 SVLEGDAHTHET-TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAED-------- 3569
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQ--RLAQEGLQPA 362
+ LE LR W+ + RL +R + + +L +F+ V + + A+E + P
Sbjct: 3570 --RALESLRQDWQAYQHRLS---ETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPR 3624
Query: 363 AK----AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
+ T++ + +++ A E V+ + A+ +E++ H +
Sbjct: 3625 TRRQSNRATKEIQLHQMKKWHEEVTAYRDE---VEEVGARAQEILDESHVNSRMGCQATQ 3681
Query: 419 TIQEYQSLKVKSARLRNAAAVEL--WQHFQRPLQDLQLWKALAQRLLEVTAS---LPDLP 473
YQ+L ++ E+ + + L W + + A+ D
Sbjct: 3682 LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
Query: 474 SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLH 533
+ L +E L + + LL + K + + + A L +++ M L
Sbjct: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
Query: 534 NSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
+++ + L+ L K+F + L + + + Q + + + +L K+AQLS+ +
Sbjct: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
Query: 594 LQEEGL-------DLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQS 646
LQ+ L + + EA LVQ+ + K+DQL SD+Q L ++ V
Sbjct: 3862 LQQTVLSHEPSVKSVREKGEALLELVQD-VTLKDKIDQLQSDYQDLCSIGKEHVFSLEAK 3920
Query: 647 VQEHCTFSHQLLELRQWIVVTTQKLEA 673
V++H ++ +L E+ +W++ + +L A
Sbjct: 3921 VKDHEDYNSELQEVEKWLLQMSGRLVA 3947
Score = 90.9 bits (224), Expect = 5e-18
Identities = 184/968 (19%), Positives = 385/968 (39%), Gaps = 104/968 (10%)
Query: 8 DFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRM 67
++ R ++ + W+ Q++L +G E L + +++ EG+ ++ VL
Sbjct: 3496 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3555
Query: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
E ++ P L+ ++ W+ ++ ++ V ++ L +F +
Sbjct: 3556 REDVI---PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVV---NKLRLMEQKFQQ 3609
Query: 128 ---WFQKMMVTLEPHIELQLGLKEKQWQLS-----HAQVLLHN--VDNQAVLLDRLLEEA 177
W + + P Q K+ QL H +V + V+ +L+E+
Sbjct: 3610 VDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDES 3669
Query: 178 ASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK 237
+ +R+G + ++ + Y A+ + +++ LE+ + EE ++ + + W
Sbjct: 3670 -HVNSRMGCQAT------QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYG 3722
Query: 238 AVVEKVNGCLGRNCKLPIT---QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG 294
+ + + K+ ++L TL+ + KD +G L++ E+ ++
Sbjct: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
Query: 295 AEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRL 354
AE++ E+ + + L++L + +E L L + + K L ++E++ +L
Sbjct: 3783 AERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVP 3842
Query: 355 AQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSD 414
+ ++ K A +Y + + + S EP V ++ + + L+ ++ L D
Sbjct: 3843 EEPKMELYEKK-------AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT-LKD 3894
Query: 415 SVIATIQEYQSLKV--KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASL--P 470
+ +YQ L K A V+ + + LQ+++ W LL+++ L P
Sbjct: 3895 KIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKW------LLQMSGRLVAP 3948
Query: 471 DL---PSLHTFLPQI---EAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAG 524
DL SL T Q+ +A + E + ++ L LQ+K D LIG L + V
Sbjct: 3949 DLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 4008
Query: 525 SMRDRDLLHNSLLQRKSKL-QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDL-P 582
++ ++++ ++ QSL + + + + LQ+ Q + A +Q DL P
Sbjct: 4009 HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQ----CQAWLSA---VQPDLEP 4061
Query: 583 GKQAQLSRLQGLQEEGLDLGAQMEAARP----LVQENPNHQHKMDQLSSDFQALQRSLED 638
Q LSR + +++ A E AR L + + D Q ++++E
Sbjct: 4062 SPQPPLSRAEAIKQV-KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQ 4120
Query: 639 LVDRCRQSVQEHCTFSHQLLELRQWIVV-----TTQKLEAHRGEAGPGDAESQEAEFERL 693
+ + + Q H EL WI + Q ++ E A++ ++ +
Sbjct: 4121 KLVQAQNLTQGWEEIKHLKSEL--WIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDF 4178
Query: 694 VAEFPEKEAQL-SLVEAQGWLVMEKSSPEGAAV--VQEELRELAESWRALRLLEESLLSL 750
V + K+A + +++E L ++ SPE + + ++ +L L L E L
Sbjct: 4179 VKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQR 4238
Query: 751 IRNWH--LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQ 808
R++H + +EV K +N+ +S + + ++ A LQE + + ED
Sbjct: 4239 TRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVH-LEALKKLALALQERKYAIEDLKD 4297
Query: 809 LLRNFGQWLQVENSKLV-------------------RIIAMRTSTAEDLRTRKSKLQELE 849
+ + L +++ +LV R I + + E+L +S+ QEL
Sbjct: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Query: 850 ARVPEGQHLFENLLRLGPARGTSDEL--------EDLRYQWMLYKSKLKDSGHLLTQSSP 901
E Q L+ P + L +L + ML KS +KD+ ++
Sbjct: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
Query: 902 GEPTGFQK 909
E QK
Sbjct: 4418 NERQVIQK 4425
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 8427 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8481
Query: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 8482 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8535
Query: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 8536 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8595
Query: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 8596 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8655
Query: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
E V Q + L G TS R + K L G ++
Sbjct: 8656 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8715
Query: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 8716 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 8774
Query: 954 TLANNFARSFTLMLRY-NGPPP 974
L+NNFARSF MLRY NGPPP
Sbjct: 8775 ALSNNFARSFHPMLRYTNGPPP 8796
Score = 68.9 bits (167), Expect = 2e-11
Identities = 115/641 (17%), Positives = 250/641 (39%), Gaps = 55/641 (8%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKA 206
++ +W S + + ++ + LD + L + + +K +++ VK
Sbjct: 2119 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL---------KKIHSSDFSLVKT 2169
Query: 207 KAQKRVDLLEQVAREHEEYQAGVD-EFQLW--LKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
+ VD V+ + EE + +W + + +++ G NC + + +S L
Sbjct: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW-SNNCVPQMAENISNLD 2228
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERL 323
+ R EE L+ E + L ++ +L+E+ K LE L E + +
Sbjct: 2229 NHL----RAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQFIEADLM 2282
Query: 324 RGLLRSRGAWEQQ---IKQLEAELSEFRMVLQRLA------QEGLQPAAKAGTEDELVAH 374
+ L ++ E +K A+ ++ + + +E L A+ T + L
Sbjct: 2283 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEAL--- 2339
Query: 375 WRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLKVKSAR 432
++ + L S++ + Q L L H+ L+ L ++ I++++++ ++
Sbjct: 2340 -KKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSK 2398
Query: 433 LRNAAAVELWQHFQRPLQDLQLW----KALAQRLLEVTASLPDLPSLHTFLPQIEAALME 488
+ + L +HF +Q+ Q W KA A+ + T D L L ++ L
Sbjct: 2399 TQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG---DSKVLEAKLHDLQNILDS 2455
Query: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
S + L + + L ++ +++ EQ+ + + L+ K LQ +
Sbjct: 2456 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2515
Query: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEK--GLQRDLPGKQAQLSRLQGLQEEGLDLGAQME 606
+ F L + +++ R E ++ +P K+ ++ +++ E L ++
Sbjct: 2516 ELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLD 2575
Query: 607 AARPLVQENPNHQH-------KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Q H QL + Q L R ++ + C+ ++QEH L
Sbjct: 2576 KLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQS 2635
Query: 660 LRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKS 718
+ W+ +L G D E + ++ + ++ E E +L++ +G + S
Sbjct: 2636 MWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSS 2695
Query: 719 SPEGAAVVQEELRELAESWRALRL----LEESLLSLIRNWH 755
+ EG V+Q +L L E W + + +L S+I W+
Sbjct: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2736
Score = 60.5 bits (145), Expect = 8e-09
Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)
Query: 143 QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182
QLG K WQ +L V + LL+ LLE + N
Sbjct: 6995 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 7049
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223
RIGD + ++A K + D +KAK +K V+ +EQ RE
Sbjct: 7050 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 7108
Query: 224 EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257
+ A +D + ++ LK+V++ K+N L +
Sbjct: 7109 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7168
Query: 258 RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
++ LQ++ D + E SL+ + +++ P E +T L+E+ + L E
Sbjct: 7169 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 7225
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
E E+L+ W Q+ K + + + E L+ A D+ VA W +
Sbjct: 7226 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7284
Query: 378 YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429
D L+ +K+ + F H L + + S + IQ Q SL
Sbjct: 7285 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7332
Query: 430 SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478
L A A V ++ F + L+ L+ W A+ +L+ + DL ++
Sbjct: 7333 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 7392
Query: 479 LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538
+ +++ +++ S + L L + + + +E ++++ R L+ + +
Sbjct: 7393 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 7446
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596
R SKLQS L QH+ F L++ ++ VQ E+ L ++ G L Q E
Sbjct: 7447 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7500
Query: 597 -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645
+ + Q + V + K+ LS+ +Q + R +
Sbjct: 7501 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7560
Query: 646 SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700
+++ + +LR+W+V + + G P + F+ + +F EK
Sbjct: 7561 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 7617
Query: 701 -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755
+ + VEA L++ S AA +Q EL E+ E W+ ++RL E+ L L+++W
Sbjct: 7618 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 7676
Query: 756 LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809
+ + + T S L + + + + R L+ GS +D +QL
Sbjct: 7677 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7731
Score = 58.5 bits (140), Expect = 3e-08
Identities = 142/799 (17%), Positives = 309/799 (38%), Gaps = 75/799 (9%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F S+++ Q W + + + + G LEA+L + + I +G+ ++D V +
Sbjct: 2411 FSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEG 2470
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR- 127
+ L A K + + + I EE ++ C + + SE D+ +
Sbjct: 2471 QTLYAHL---SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Query: 128 --WFQKM--MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
W +M E E + + EK+ ++ ++ L + LD+L + L
Sbjct: 2528 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2587
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
+ ++ + + ++++ + +EHE + + W+KA+ +++
Sbjct: 2588 GHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRL 2647
Query: 244 ---NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
LG K + +RLS +QDI GE L + +R+++ G I
Sbjct: 2648 ACAESTLG--SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT 2705
Query: 301 ELEEMRKV--------------LEKLRALWEEEEERLRGLLRSRGAWEQQIK---QLEAE 343
+LE +++V LE + + W + ER L + + +Q+I+ Q +
Sbjct: 2706 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2765
Query: 344 LSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI 403
L E ++L L Q L A ED A R + +R E + AQ +EL
Sbjct: 2766 LKEKFVLLDHL-QSILSEA-----EDHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELK 2818
Query: 404 VFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLL 463
+++ ++ + ++E VK + A E ++L W ++
Sbjct: 2819 TQFNDIMTVAKEKMRKVEEI----VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG--- 2871
Query: 464 EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVA 523
+ +A+ L + + E SR++ L ++K++ G E ++ +
Sbjct: 2872 DSSATQKKLSKIKELIDSREIGASRLSRVESLAP--EVKQNTTAS--GCELMHTEMQALR 2927
Query: 524 GSMRDRDLLHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQR 579
+ + +S+ Q +S L++L++Q ++F L++ L ++
Sbjct: 2928 ADWKQWE---DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT 2984
Query: 580 DLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDL 639
L GK + +G ++ ++ A P ++ + +++ + S D + L
Sbjct: 2985 LLEGKNTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGL 3043
Query: 640 VDR----CRQSVQEHCTFSHQLLELR---------QWIV---VTTQKLEAHRGEAGPGDA 683
+ C Q+ + C Q+L+ R QW+V +TT K +
Sbjct: 3044 IKEYNCLCLQA-SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAK--CFDIPQNISEV 3100
Query: 684 ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLL 743
+ + + ++E + +L+++ ++G L+ + E A +Q ++ E W+
Sbjct: 3101 STSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3160
Query: 744 EESLLSLIRNWHLQRMEVD 762
S + N +Q + +
Sbjct: 3161 LHQKESALENLKIQMKDFE 3179
Score = 58.2 bits (139), Expect = 4e-08
Identities = 143/777 (18%), Positives = 288/777 (37%), Gaps = 92/777 (11%)
Query: 12 SVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEAL 71
+V + W+ + +++L + G +A + +L + +++ G R+ V +A +
Sbjct: 2848 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2907
Query: 72 LACCPGDQKPGILARLKDIKA---QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ ++ ++A QWE++V C + S+ L+ EF
Sbjct: 2908 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEFSGQ 2961
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAV--------LLDRL------L 174
++ LE Q K W + N D + V +LD L
Sbjct: 2962 VAQLEQALE-----QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3016
Query: 175 EEAASLFNRI----GDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
E+ S N + D S + EY+ + +A K EQ+ ++ ++
Sbjct: 3017 EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRKAFR 3074
Query: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
+FQ WL N K+ + Q+I++ ++ E L E G +
Sbjct: 3075 DFQQWLV------------NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3122
Query: 291 SPLGAEKITGEL---EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEF 347
L ++ L E+ + + K+ A +E+ + L + E ++ L+ ++ +F
Sbjct: 3123 MMLSKGELLSTLLTKEKAKGIQAKVTAA-KEDWKNFHSNLHQK---ESALENLKIQMKDF 3178
Query: 348 RMVLQRLAQEGLQPAAKAGTED-----ELVAHWRRYSATRAALAS---EEPRVDRLQAQL 399
+ + + Q+ L K E +L A R ++ L EP+++RL+ +
Sbjct: 3179 EVSAEPI-QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA 3237
Query: 400 KELIV-------FPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDL 452
++L F H + LS +A K K +RL A F +++L
Sbjct: 3238 QQLWEGQAASKSFRHRVSQLSSQYLALSN---LTKEKVSRLDRIVAEH--NQFSLGIKEL 3292
Query: 453 QLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Q W A +L+ D L + ++EA L + + M+ + + ++
Sbjct: 3293 QDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3352
Query: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
E + +Q+ L ++ ++ KS+L+ L++ + + ++ +
Sbjct: 3353 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3412
Query: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
+ +L K L + + L EE L + +E H Q ++ L
Sbjct: 3413 NESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQER 3472
Query: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEA 688
++A+Q ++ V + + V+ H + L W+ +KL+ + GDA + E
Sbjct: 3473 YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY--SVLEGDAHTHET 3530
Query: 689 EFERLVAEFPEKEAQLSLVEAQGWL-----VMEKSSPEGAAVVQEE-LRELAESWRA 739
L +E Q+ E Q L E P G ++ L L + W+A
Sbjct: 3531 TLRDL------QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA 3581
Score = 52.0 bits (123), Expect = 3e-06
Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266
+A+ R+ L Q A EEY ++ W++ +G + N + ++ Q +
Sbjct: 5514 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5573
Query: 267 KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326
++ + LE + E+ + TS EK++ ++ E+ + E+LR + + + L+
Sbjct: 5574 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5630
Query: 327 LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
+ +E ++K+L+A L + + L P + E ++H + + +L
Sbjct: 5631 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
Query: 387 SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440
+ V Q+ L+ P ++ PL + + +E L+ ++ + AA V+
Sbjct: 5684 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 5739
Query: 441 LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Q+ Q QL + + + + + ++ L + + E + +E + L
Sbjct: 5740 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 5799
Query: 501 LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
K +L + AT LL +V G + L LL S S++
Sbjct: 5800 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 5851
Query: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601
LL E+G ++ A ++ Q L E L
Sbjct: 5852 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
Query: 602 GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
A++ + QE P + D Q +L++++ ++++ E + +
Sbjct: 5911 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 5970
Query: 660 LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712
Q I + +E E+ PG ESQ AE + L+ E E Q SL E
Sbjct: 5971 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 6027
Query: 713 LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757
LV E ++ P +Q L LAE +R LLEE L + +
Sbjct: 6028 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 6087
Query: 758 -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813
R E D + + L P +P+ + N+L E E S+
Sbjct: 6088 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 6142
Query: 814 GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872
L V N L ++ + T ++ KL+ L+ + E Q L + L + +GT+
Sbjct: 6143 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 6194
Query: 873 DELED 877
E E+
Sbjct: 6195 QEKEE 6199
Score = 51.2 bits (121), Expect = 5e-06
Identities = 113/613 (18%), Positives = 226/613 (36%), Gaps = 39/613 (6%)
Query: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 7891 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 7948
Query: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 7949 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 8008
Query: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 8009 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 8068
Query: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 8069 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 8127
Query: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 8128 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 8186
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVL---QRLAQ 356
EL+E+R+ +++ E ++L L + ++LE E S L R A
Sbjct: 8187 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8246
Query: 357 EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSV 416
L P + L R + R AS VD + + +L+
Sbjct: 8247 SLLSPQPSSNLSLSLAQPLRSERSGRDTPAS----VDSIPLEWDHDYDLSRDLESAMSRA 8302
Query: 417 IATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLE-------VTASL 469
+ + ++ + K LR A + H Q QL KAL + + +
Sbjct: 8303 LPS-EDEEGQDDKDFYLRGAVGLS-GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKT 8360
Query: 470 PDLPSLHTFLPQIEAALMESS----RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525
P P L T L E S +K L L+ +++ L G Q AG
Sbjct: 8361 PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET---QTAGV 8417
Query: 526 MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ--RDLPG 583
+ +LL L ++ +++ L + + F + + L D + ++ + L+ D+
Sbjct: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
Query: 584 KQAQLSRLQGLQE 596
+ Q+ +L+ LQ+
Sbjct: 8478 IELQIKKLKELQK 8490
Score = 48.1 bits (113), Expect = 4e-05
Identities = 99/619 (15%), Positives = 243/619 (39%), Gaps = 97/619 (15%)
Query: 171 DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
+R L++ A L E Q++M + + + ++ ++Q+ +H+EY G++
Sbjct: 6592 ERALQDLADLL---------ETGQEKMAGDQKIIVSSKEE----IQQLLDKHKEYFQGLE 6638
Query: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
+ + + K+ + T+ ++ + K + LE + E + + +
Sbjct: 6639 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6698
Query: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERL-------RGLLRSRGAWEQQIKQ---- 339
++++ +LE + + + L EE E+RL + L S ++ ++ Q
Sbjct: 6699 -----QELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 6752
Query: 340 -----LEAELSEFRMVLQRLAQEGLQPAAKAGTE----DELVAHWRRYSATRAALASE-E 389
+ S+ L +L + L K E + ++ HW RY + A L +
Sbjct: 6753 GKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6812
Query: 390 PRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPL 449
DRL+ ++ + P L+ + D + A ++ + + +S+ + + + +
Sbjct: 6813 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6872
Query: 450 QDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSR-LKELLTMLQLKKDLLIG 508
L L++ + T L ++P++ L Q++ + S + E+++ + L ++++
Sbjct: 6873 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-- 6930
Query: 509 IFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ 568
+D D + NS+ + A E LQ+
Sbjct: 6931 -----------------QKDEDNIKNSI---------------GYKAIHEYLQKY----- 6953
Query: 569 VRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ-MEAARPLVQENPNHQHKMDQLSS 627
KG + D+ KQ + + + L + +Q +E+ R + + ++ ++
Sbjct: 6954 ------KGFKIDINCKQLTVDFVN---QSVLQISSQDVESKR---SDKTDFAEQLGAMNK 7001
Query: 628 DFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQE 687
+Q LQ + + + ++ + + + L+ W ++L+ ++
Sbjct: 7002 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAL 7061
Query: 688 AEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRAL----RLL 743
+ + L KE ++ +E G +++ + +++V LREL ++W L L
Sbjct: 7062 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7121
Query: 744 EESLLSLIRNWHLQRMEVD 762
+ L S++ W ++ D
Sbjct: 7122 KILLKSVLDQWSSHKVAFD 7140
Score = 47.0 bits (110), Expect = 9e-05
Identities = 73/378 (19%), Positives = 145/378 (38%), Gaps = 60/378 (15%)
Query: 90 IKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLE-PHIELQLGLKE 148
++ Q+E+ + + +E + HW F W ++ P +++ +
Sbjct: 1632 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1691
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK- 207
+ +L Q L + V +QA +LL+ SLF+ +D K MK + + +
Sbjct: 1692 VEGELQLIQALQNEVVSQASFYSKLLQLKESLFS-----VASKDDVKMMKLHLEQLDERW 1746
Query: 208 ------AQKRVDLLEQVAREHEEYQAGVDEFQLWL------------------------- 236
KR++ L+ V EH+++ + F +W+
Sbjct: 1747 RDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRH 1806
Query: 237 ----------KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKD-FPRGEESLETLEEQSAG 285
K ++ + G L + L + L LQ A+D F EE+ + +E +
Sbjct: 1807 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA 1866
Query: 286 VIRNTSPLGAE-KITGELEEMRKVLEKLRALWEEE----EERLRGLLRSRGAWEQQIKQL 340
+ L + ++G L ++R+ +E ++ + E E+ L L++ A E L
Sbjct: 1867 LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSL 1926
Query: 341 EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRL----Q 396
+ LS+ + L+ + E Q + T D+L R SE + L Q
Sbjct: 1927 DGILSKAQYHLKIGSSE--QRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ 1984
Query: 397 AQLKELIVFPHNLKPLSD 414
Q +EL+ +++ +D
Sbjct: 1985 DQKEELLKSIEDIEERTD 2002
Score = 45.8 bits (107), Expect = 2e-04
Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)
Query: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61
+ F +S+E +AW+ ++ LQ D + + ++ R+ E + K + P+
Sbjct: 7355 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7414
Query: 62 DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114
+L R+ P + K + R++++ W + T S+++ L
Sbjct: 7415 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 7464
Query: 115 ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
W E+L+ + QK+ V + + + L +++ +L A++ ++++D
Sbjct: 7465 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 7517
Query: 172 --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224
RLLE+ VD+ + +K ++ V +AQ+R +++ R+ +
Sbjct: 7518 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7567
Query: 225 YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281
Y+ ++ + WL V LG + +P+ Q + ++ K F R + S E
Sbjct: 7568 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7626
Query: 282 QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341
++ + + EL E+++ + EE++++L LL+ WE+ K +
Sbjct: 7627 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 7683
Query: 342 AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401
L + R ++L+Q + +EL A R A+ S + +L + LK+
Sbjct: 7684 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 7736
Query: 402 LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456
+ + ++ L++ V ++++ L ++ R + + W F ++L W
Sbjct: 7737 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 7795
Query: 457 ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515
L Q +V+ + L + + +++ E + +E LQ + L + +A
Sbjct: 7796 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7852
Query: 516 TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574
+ +E G + DR L + + R KL+ L + L+ L + +
Sbjct: 7853 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 7909
Query: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632
K + D + +L QE D+ ++ H D ++D + ++
Sbjct: 7910 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 7969
Query: 633 QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678
Q++ +L R C S++ F W+ ++++ A +
Sbjct: 7970 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 8028
Query: 679 GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736
G A+ + +FE + E QL L+ Q + ++ + A +++ + E +
Sbjct: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8088
Query: 737 WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768
W L+ S+L ++++ QR E ++ + +
Sbjct: 8089 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 8120
Score = 45.4 bits (106), Expect = 3e-04
Identities = 82/429 (19%), Positives = 166/429 (38%), Gaps = 64/429 (14%)
Query: 266 AKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE-------- 317
A + P G ++ + L++Q+ + +K+ LEE K +E ++ W+
Sbjct: 1403 ASEIPLGPQNKQLLQQQAKSIKEQV-----KKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1457
Query: 318 ------EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
E+E+ L L S A + QI Q++ + E L + GL+ A++ +
Sbjct: 1458 LSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV--GLEEEAQSFAQFVT 1515
Query: 372 VAHWRRYSA--TRAALASEEPRVDR------LQAQLKELIVFPHNLKPLSDSVIATIQEY 423
R A T+ EE R + L + F NL+ + SV + ++
Sbjct: 1516 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSV-SEFEDK 1574
Query: 424 QSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
++ +K ++A E ++ Q + Q ++L+ + +AS
Sbjct: 1575 LAVPIKIC----SSATETYKVLQEHMDLCQALESLSSAITAFSASA-------------R 1617
Query: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
+ S ++E + Q +D+L +ER TAL +A R L + L +
Sbjct: 1618 KVVNRDSCVQEAAALQQQYEDILRR--AKERQTALENLLAHWQRLEKELSSFLTWLERGE 1675
Query: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGA 603
+ D A ++ +L Q + LQ ++ + + S+L L+E + +
Sbjct: 1676 AKASSPEMDISADRVKVEGEL-------QLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1728
Query: 604 QMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQW 663
+ + + ++QL ++ L + + ++ + V EH F LL W
Sbjct: 1729 KDDVKMMKLH--------LEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1780
Query: 664 IVVTTQKLE 672
I + +L+
Sbjct: 1781 IKLFLSELQ 1789
Score = 43.9 bits (102), Expect = 7e-04
Identities = 127/632 (20%), Positives = 245/632 (38%), Gaps = 101/632 (15%)
Query: 115 WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK-EKQWQLSHAQVLLHNVDNQAVLLDRL 173
W +Y AR+E L L+ E + +LS + L+ V++ + L
Sbjct: 5103 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5162
Query: 174 LEEAASLFNRIGDPSVDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
EE AS + G+ + + M + ++A AQ + +LE E + V
Sbjct: 5163 -EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVK 5221
Query: 231 EFQLWLKAVVEKVNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRN 289
+ + + +K+ G K + L + + + +L L +Q+ ++++
Sbjct: 5222 KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQD 5281
Query: 290 TS-------PLGAEKITGELEEMRKVLEKLRALWE------EEEERLRGLLRSRGAWEQQ 336
+ P ++IT + + EK++ + ++ E + + S W Q+
Sbjct: 5282 GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5341
Query: 337 IKQ--------LEAELSEFRMVLQRLA--QEGLQPAAKAGTEDELVAHW---RRYSATRA 383
K+ ++A+L E +++L ++ ++ A+ E L + S A
Sbjct: 5342 TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLA 5401
Query: 384 ALASEEPRVDRLQAQLKE---------------------LIVFPHNLKPLSDSVIATIQE 422
+A + D++Q ++KE L LK +D+V+ Q
Sbjct: 5402 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV---QA 5458
Query: 423 YQSLKVKSARLR--NAAAVELWQHFQRPL-QDLQLWKALAQRLLEVTA----SLPDLPSL 475
KV L N+ +EL Q+ L Q+ QL K LA+++ ++T ++ +
Sbjct: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5518
Query: 476 HTFLPQIEAALMESSRLKEL-LTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHN 534
+ L Q + L E + + EL L ++ K L G A+ L EQ +LH
Sbjct: 5519 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY--------ILHQ 5570
Query: 535 SLLQRKSKLQSLLA--------------------QHKDFGAAFEPLQRKLLDLQVRVQAE 574
+LL+ ++ S L Q + G E L++ + ++R+Q
Sbjct: 5571 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 5627
Query: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH-QH---KMDQLSSDFQ 630
+ +D+ +A+L +LQ E+ E R ++E +H QH +M+ L Q
Sbjct: 5628 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ 5687
Query: 631 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQ 662
A+Q L R + V H L L++
Sbjct: 5688 AVQLCQSAL--RIPEDVVASLPLCHAALRLQE 5717
Score = 40.4 bits (93), Expect = 0.008
Identities = 87/448 (19%), Positives = 187/448 (41%), Gaps = 40/448 (8%)
Query: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV-----DEFQLWLKA 238
+G+P+++ DAQ E + +A +E++A E +E G+ E L L
Sbjct: 5346 LGNPTIEIDAQLE---ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5402
Query: 239 VVE--KVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLET----LEEQSAGVI--RNT 290
V K+ + K + Q +T Q++++ + + L T L+ ++ V+ +
Sbjct: 5403 VALDLKIRDQIQDKIK-EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5461
Query: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAW----EQQIKQLEAELSE 346
+ E++ G ++ ++ ++ E+ + + L + G +Q I+Q E LS+
Sbjct: 5462 QKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5521
Query: 347 FRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALASEEPRVDRLQAQLK 400
L + E L+ K + +++AH W S R + ++ +
Sbjct: 5522 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5581
Query: 401 ELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
EL L+ L+ SV T Q+ L ++ LR + L Q+ Q +D++ ++A
Sbjct: 5582 ELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QNLQDAAKDMKKFEA 5639
Query: 458 LAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
++L + T + P++ SL L + L E LK + +QL + L
Sbjct: 5640 ELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP 5699
Query: 510 FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569
+ L + L ++ +Q+ + +Q+ + Q++ + + LQ+ +
Sbjct: 5700 EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR 5759
Query: 570 RVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
++ + ++ QAQ+SR + L ++
Sbjct: 5760 EIEDKPVATSNIQELQAQISRHEELAQK 5787
Score = 38.5 bits (88), Expect = 0.031
Identities = 94/549 (17%), Positives = 221/549 (40%), Gaps = 65/549 (11%)
Query: 101 MTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL 160
+T C SR+ + ++ W +++ L + L L L++ Q ++ Q+
Sbjct: 4876 VTECESRM----VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4931
Query: 161 HNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMKAEYD-----AVKAKAQKRVDL 214
V + +++ L + F + + S D + +E D A++ + ++
Sbjct: 4932 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4991
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
Q R ++ +QA D WL+ E + L N L + L+ + F ++
Sbjct: 4992 YSQCQRYYQVFQAAND----WLEDAQELLQ--LAGN-GLDVESAEENLKSHMEFFSTEDQ 5044
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLE-KLRALWEEEEERLRGLLRSRGAW 333
LEE + ++ PL +LE+ LE + + + + ++ L R W
Sbjct: 5045 FHSNLEELHS-LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5103
Query: 334 EQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVD 393
K E + ++L++ L + + +E ++ + A + + S ++
Sbjct: 5104 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE---HKALVSVVNSFHEKIV 5160
Query: 394 RLQAQLKELIVFPHNLKPLSDSVIATI-QEYQSLKVKSARLRNAAAVELWQHFQRPLQD- 451
L+ + +L K +D+ AT+ + ++ + RLR A Q ++ L+D
Sbjct: 5161 ALEEKASQLE------KTGNDASKATLSRSMTTVWQRWTRLRAVA-----QDQEKILEDA 5209
Query: 452 LQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
+ W ++ + T + L ++ + E + ELLT+L+ ++ +
Sbjct: 5210 VDEWTGFNNKVKKATEMIDQLQD------KLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5263
Query: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Q+ A +L Q SM L + + L+ + +Q + L++Q +V
Sbjct: 5264 QQSALGMLRQQTLSM-----LQDGAAPTPGEEPPLMQE-------ITAMQDRCLNMQEKV 5311
Query: 572 QAE-KGLQRDLPGKQAQLSRLQGLQ-----------EEGLDLGAQMEAARPLVQENPNHQ 619
+ K ++++L ++ +++ ++ +++ AQ+E + L+ E NH+
Sbjct: 5312 KTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHR 5371
Query: 620 HKMDQLSSD 628
+++++ +
Sbjct: 5372 QNIEKMAEE 5380
Score = 33.9 bits (76), Expect = 0.76
Identities = 123/705 (17%), Positives = 259/705 (36%), Gaps = 79/705 (11%)
Query: 78 DQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ--KMMVT 135
++ ++ + + AQW + S +E V +W Y W + + M+
Sbjct: 578 EEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN 637
Query: 136 LEPHIELQLGLKEKQWQLSHAQV------LLHNVDNQAVLLDRLLEEAASLFNRIGDPSV 189
+ + W H + L+ D ++ R L++ L N
Sbjct: 638 QSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDE---MVSRDLKQQLLLLN------- 687
Query: 190 DEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGR 249
R + + VK AQ D ++++ +E+ + + F + +
Sbjct: 688 -----GRWRELFMEVKQYAQ--ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFM 740
Query: 250 NCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVL 309
N KL I L+DI + P + + + + + + + + +++ + ++++ L
Sbjct: 741 NVKLLI----QDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQL 796
Query: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
K++ + + LL E+Q+ L + ++ L +E A
Sbjct: 797 TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 856
Query: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLK 427
EL+A T + V + L F + ++D +A +QS+
Sbjct: 857 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA----FQSMV 912
Query: 428 VKSARLRNAAAV--ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT-FLPQIEA 484
K+ + L + F+ +L+ +AQ LE +L HT F Q++
Sbjct: 913 KKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD- 971
Query: 485 ALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
+ +L D L I ++ L E V + L L+
Sbjct: 972 --------QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1023
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLS----------RLQGL 594
+ +++ F A+ E R LD + ++ ++G ++ + + S RLQ +
Sbjct: 1024 IDVEKNR-FLASVEEC-RTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI 1081
Query: 595 QEEGLDLGAQMEAARPLVQENPNHQH-KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
+E + L R V++ P H + +L + + R L + D+ + +
Sbjct: 1082 EELCVKL-----PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD-------Y 1129
Query: 654 SHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEF----PEKEAQLSLVEA 709
+ + E WI +L+ +GEA + E +R V E ++ LS +++
Sbjct: 1130 TSRFSEFSSWISTNETQLKGIKGEA---IDTANHGEVKRAVEEIRNGVTKRGETLSWLKS 1186
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNW 754
+ ++ E SS A +EL +L+ S++AL L + ++ N+
Sbjct: 1187 RLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1231
Score = 33.1 bits (74), Expect = 1.3
Identities = 30/163 (18%), Positives = 72/163 (44%), Gaps = 1/163 (0%)
Query: 195 KRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK-AVVEKVNGCLGRNCKL 253
+ +++ YD+V K R+ LE+ + ++ D+ WLK A + N
Sbjct: 4537 QELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESS 4596
Query: 254 PITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLR 313
+ +L+ Q+I + P E L TL+ ++ + + + ++ +L + + +
Sbjct: 4597 ELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIV 4656
Query: 314 ALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
AL +++ +++ + +R + I+ LSE R+++
Sbjct: 4657 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSK 4699
Score = 32.0 bits (71), Expect = 2.9
Identities = 118/640 (18%), Positives = 229/640 (35%), Gaps = 82/640 (12%)
Query: 85 ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQL 144
++L + W M+ R+E + HW+ Y + W Q LE + +
Sbjct: 6767 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6826
Query: 145 GL-KEKQWQLSHAQVLLH---NVDNQAVLLDRLLEEAASLFN-RIGDPSVDEDAQKRMKA 199
+ +E + H L VD Q+ L +L L + D + R+ +
Sbjct: 6827 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 6886
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW---LKAVVEK----VNGCLGRNCK 252
++ + + L Q+ + + + E W ++ V++K + +G
Sbjct: 6887 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6946
Query: 253 LPITQRLS------TLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMR 306
Q+ + + DF +S+ + Q R+ AE +L M
Sbjct: 6947 HEYLQKYKGFKIDINCKQLTVDFV--NQSVLQISSQDVESKRSDKTDFAE----QLGAMN 7000
Query: 307 KVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAG 366
K + L+ L E+ + L GLL S +E ++ L+ L++ + G Q + +
Sbjct: 7001 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNA 7060
Query: 367 TEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSL 426
+D + ++E V++++ L + + + +S V++T++E
Sbjct: 7061 LKD--------CQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVMSTLRELGQT 7110
Query: 427 ------KVKSARLRNAAAVELW-----------QHFQRPLQDLQLWKALAQRLLEVTASL 469
V ++ + ++ W + L ++ L L V +
Sbjct: 7111 WANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV 7170
Query: 470 PDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDR 529
+L +L L + E +L + + QL K+ + E T L++V +MR
Sbjct: 7171 DNLQNLQDDLEKQERSLQKFGSITN-----QLLKECHPPV--TETLTNTLKEV--NMRWN 7221
Query: 530 DLLHN--SLLQRKSKLQSLLAQHKDFG---AAFEPLQRKLLDLQVRVQAEKGLQRD---- 580
+LL LQ L L ++KD+ A+ Q + ++ K + D
Sbjct: 7222 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT 7281
Query: 581 --------LPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQAL 632
L G L L E G L Q++A+ Q LS AL
Sbjct: 7282 WIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-----IQSDQLSLSQHLCAL 7336
Query: 633 QRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
+++L + V ++ TF+ L L WIV + L+
Sbjct: 7337 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ 7376
Score = 30.8 bits (68), Expect = 6.5
Identities = 82/380 (21%), Positives = 150/380 (39%), Gaps = 66/380 (17%)
Query: 257 QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE------------KITGELEE 304
QR+S L+D + E+ + LE Q V S + E + G L++
Sbjct: 4768 QRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQD 4827
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
VL+++ E+ L L A+E+ Q+++ E +++ + +
Sbjct: 4828 SGIVLKRVTIHLEDLAPHLDPL-----AYEKARHQIQSWQGELKLLTSAIGE-------- 4874
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
T E + + + ++ + R++A+L + NL+ + + I IQ +Q
Sbjct: 4875 --TVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE-IRKIQIHQ 4931
Query: 425 SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLP-SLHTFLPQIE 483
S R+ NA + + + F + + ++ L A L +L + L +
Sbjct: 4932 EEVQSSLRIMNALSHKEKEKFTKAKE------LISADLEHSLAELSELDGDIQEALRTRQ 4985
Query: 484 AALME-SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRD-------------- 528
A L E S+ + + Q D L E A LL Q+AG+ D
Sbjct: 4986 ATLTEIYSQCQRYYQVFQAANDWL------EDAQELL-QLAGNGLDVESAEENLKSHMEF 5038
Query: 529 ---RDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQ---AEKGLQRDLP 582
D H++L + S + +L K G E L++K+ L++R Q + G Q DL
Sbjct: 5039 FSTEDQFHSNLEELHSLVATLDPLIKPTGK--EDLEQKVASLELRSQRMSRDSGAQVDLL 5096
Query: 583 GK-QAQLSRLQGLQEEGLDL 601
+ AQ Q +EE ++L
Sbjct: 5097 QRCTAQWHDYQKAREEVIEL 5116
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 96.7 bits (239), Expect = 1e-19
Identities = 81/341 (23%), Positives = 164/341 (48%), Gaps = 15/341 (4%)
Query: 5 PQDD--FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVD 62
P +D F+ D W+K +++ L V ++++G + LE R+ + ++I L+PEG R++
Sbjct: 2040 PTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG-KMPLEERIQKIKEIILLKPEGDARIE 2098
Query: 63 LVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+++ AE+ + P + L DI QW+ T+ + S E + L +YL ++
Sbjct: 2099 TIMKQAES-------SEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
Query: 123 DEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN 182
++ ++ E LQ GL+EK+ QL + L + LL L + L
Sbjct: 2152 EDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE 2211
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEK 242
+PS E+ +K ++++ + Q V L+ REH+ YQ V + L ++
Sbjct: 2212 CTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKE 2271
Query: 243 VNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGE 301
+ ++ + ++L LQ++ + +L+ + + V +NTS +G + I +
Sbjct: 2272 FVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD 2331
Query: 302 LEEM---RKVLE-KLRALWEEEEERLRGLLRSRGAWEQQIK 338
++ + +K LE +L + +E E L +L+S+ + E++ K
Sbjct: 2332 IKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGK 2372
Score = 82.4 bits (202), Expect = 2e-15
Identities = 92/345 (26%), Positives = 145/345 (42%), Gaps = 19/345 (5%)
Query: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 6571 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6627
Query: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQR 758
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 6628 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 6686
Query: 759 MEVDSGKK-----MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQEEEGSHEDFSQLLRN 812
+ + + N + + +P DP R L+Q E+ E Q+
Sbjct: 6687 QDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV--- 6743
Query: 813 FGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQHLFENLLRLGPARGT 871
++ NS L++ AE+ + + KL++L +V + + +
Sbjct: 6744 -DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPS 6802
Query: 872 SDELEDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRGLGSLFRRACCVALPLQ 931
DE++ + + + E T + R S R ALPLQ
Sbjct: 6803 FDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ 6862
Query: 932 LLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPPT 975
LLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPPT
Sbjct: 6863 LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 6907
Score = 49.7 bits (117), Expect = 1e-05
Identities = 156/863 (18%), Positives = 329/863 (38%), Gaps = 153/863 (17%)
Query: 11 RSVEDAQAWMKAVQDQLQVNDNTQGPRAALEAR-LWETEKICQLEPEGRVRVDLVLRMAE 69
+++ + +WM V+ Q D+ P +A + + L + K ++E + + + + +
Sbjct: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 70 ALLACCPGDQK----PGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEF 125
L+ C + K L ++ QW H + H + L + E
Sbjct: 5123 LQLSTCDVESKRYERTEFAEHLGEMNRQWHRV-------HGMLNRKIQHLEQLLESITES 5175
Query: 126 YRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL--HNVDNQAVLLDRLLEEAASLFNR 183
Q + LE E L++ + +S ++LL +++NQ + + L+E +
Sbjct: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLT 5235
Query: 184 IGDPSVD--EDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVE 241
+ +V ED R+ + QKR +L QV + Q+ + E++++ + +
Sbjct: 5236 LESGAVPLLEDTASRIDELF-------QKRSSVLTQVNQLKTSMQSVLQEWKIY-DQLYD 5287
Query: 242 KVNG-------CLGRNCKLPIT--------QRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
+VN C+ + + ++ + L +LQD A+ E L+ + + G+
Sbjct: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
Query: 287 IRNTSPLGAEK--------------ITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGA 332
+ + + EK I +L++ + +L+ +A E L +
Sbjct: 5348 CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAK 5407
Query: 333 WEQ--------------------QIKQLEAELSEFR-------MVLQRLAQ--------- 356
++Q IK+L+ ++ + + VL RL Q
Sbjct: 5408 FQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHML 5467
Query: 357 -----EGLQPAA--------KAGTEDELVAHWR----RYSATRAALASEEPRVDRLQAQL 399
LQ AA KA + +++ ++ R + + + EE +DRL Q
Sbjct: 5468 LPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQE 5527
Query: 400 KE-----------LIVFPHNLK---------PLSDSVIATIQEY--QSLKVKSARLRNAA 437
KE L +++ PLSD + T+Q Q ++ + L +
Sbjct: 5528 KENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCS 5587
Query: 438 AVELWQHFQRPLQDLQLWKALAQRL-----LEVTASLPDLPSLHTFLPQIEAALMESSRL 492
++ ++ L + W L +++ ++V SLP+L +EA + + +
Sbjct: 5588 ELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTI 5647
Query: 493 KELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKD 552
+ L+ LL + R + E + R ++ + + QRK + L+ Q +D
Sbjct: 5648 ADSYVTQSLQ--LLDTTEIENRPEFITEFSKLTDRWQNAVQG-VRQRKGDVDGLVRQWQD 5704
Query: 553 FGAAFEPLQRKLLDLQVRVQAEKGLQR-----------DLPGKQAQLSRLQGLQEEGLDL 601
F + E L R L D + A KG +R +L K+ R + L+
Sbjct: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
Query: 602 GAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELR 661
G ++ L + + ++ QL ++ ++ L +++ + + +V+ ++ EL+
Sbjct: 5765 GEKLLLTTDL-KTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELK 5823
Query: 662 QWIVVTTQKLEAHRGEAGPGDAESQE--AEFERLVAEFPEKEAQLSLVEAQGWLVMEKSS 719
+ V + E E +E E E+ +A + + +L ++A +
Sbjct: 5824 SRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD---LTRHVL 5880
Query: 720 PEGAAVVQEELRELAESWRALRL 742
E V++E++ L W L L
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCL 5903
Score = 45.4 bits (106), Expect = 3e-04
Identities = 122/659 (18%), Positives = 243/659 (36%), Gaps = 94/659 (14%)
Query: 136 LEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQK 195
L+ H E ++ + KQW + L + V R E +G+
Sbjct: 5098 LQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRY--ERTEFAEHLGE--------- 5146
Query: 196 RMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPI 255
M ++ V +++ LEQ+ E + + WL+A E++ + +
Sbjct: 5147 -MNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRAL 315
+ L QDI ++L+ L++ + PL E ++E+ + +
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-LEDTASRIDELFQKRSSVLTQ 5264
Query: 316 WEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHW 375
+ + ++ +L+ ++Q ++ F ++ L + + L
Sbjct: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVL-------SLETLRCQV 5317
Query: 376 RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQE-YQSLKVKSARLR 434
+ + S E ++LQ + + LK L SV I+E Q+ + ++
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGK-------LKGLCPSVAEIIEEKCQNTHKRWTQVN 5370
Query: 435 NAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKE 494
A A +L Q+ LQLWKA + E A L + L I M + L E
Sbjct: 5371 QAIADQL----QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS---MSGNNLAE 5423
Query: 495 LL-TMLQLKKDLLIGIFGQERA-------------------TALLEQVAGSMRDRDLLHN 534
+L LQ K+L + + A LL S++ L
Sbjct: 5424 ILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 535 SLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGL 594
LL + ++ + +L+Q KDFG VR+++ KGL + ++ L RL
Sbjct: 5484 MLLVKANEFEFVLSQFKDFG--------------VRLESLKGL---IMHEEENLDRLHQQ 5526
Query: 595 QEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFS 654
++E D + + L ++P+ +H ++++S +++ L + RQ ++ T
Sbjct: 5527 EKENPD--SFLNHVLALTAQSPDIEH-LNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL 5583
Query: 655 HQLLELR-------------QWIVVTTQKLEAHRGEAGPGDAE--SQEAEFERLVAEFPE 699
+ EL+ +WI + + EA + + E Q+ ++ L AE
Sbjct: 5584 ERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 700 KEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESW----RALRLLEESLLSLIRNW 754
+ Q +++ + E E +L + W + +R + + L+R W
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
Score = 40.4 bits (93), Expect = 0.008
Identities = 57/313 (18%), Positives = 127/313 (40%), Gaps = 20/313 (6%)
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
+Y V +A+ R L + + EEY + + W++ + + ++
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHA 3824
Query: 260 STLQDIAKDFPRGEESLET--LEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
ST+Q +D + L + ++ + +I T +++T ++E+ + L+
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIFET-----DELTQSIQELSNQVTALQQKIM 3879
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
E +++ + A E ++K +E +S+ + +L P + ++ + R
Sbjct: 3880 ESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRP 3939
Query: 378 YSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSD-SVIATIQEYQSLKVKSARLRNA 436
T A + S + + Q +K L VF + L D ++ + + Q+ +K +
Sbjct: 3940 MKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTN 3999
Query: 437 AAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELL 496
E ++ ++ L + +L + LP L Q E ME K++L
Sbjct: 4000 EWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL--------QGEIERME----KQIL 4047
Query: 497 TMLQLKKDLLIGI 509
++ Q K+DLL+ +
Sbjct: 4048 SLNQRKEDLLVDL 4060
Score = 39.7 bits (91), Expect = 0.014
Identities = 53/316 (16%), Positives = 118/316 (37%), Gaps = 20/316 (6%)
Query: 10 DRSVEDAQAWMKAVQDQLQ------VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
D+++ + + W+ ++ +L V D+ + ++ RL E + + + + V+
Sbjct: 6028 DKNMSNLRTWLARIESELSKPVVYDVCDDQE-----IQKRLAEQQDLQRDIEQHSAGVES 6082
Query: 64 VLRMAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYL 119
V + + LL AC + I + + +W +IE W W ++L
Sbjct: 6083 VFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFL 6142
Query: 120 LARDEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEE 176
F W + T P+ L KE+ + Q +H Q L+++
Sbjct: 6143 DDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRR 6202
Query: 177 AASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWL 236
A NR S + +D ++ + + L + EE++ + +WL
Sbjct: 6203 LAR-ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL 6261
Query: 237 KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE 296
+ ++ + + ++ L ++ ++ L +I+ + PL A
Sbjct: 6262 TEMDLQLTN-VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAV 6320
Query: 297 KITGELEEMRKVLEKL 312
I ELEE+ + +++
Sbjct: 6321 LIEDELEELHRYCQEV 6336
Score = 37.4 bits (85), Expect = 0.069
Identities = 64/311 (20%), Positives = 129/311 (41%), Gaps = 36/311 (11%)
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQ-HKDFGAAFEPLQRKLLDLQVRVQAEKG 576
+ EQ +G+ +++ L K K++ L Q + D A L++ +L++ A+
Sbjct: 6547 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKP- 6605
Query: 577 LQRDLPGKQAQLSRLQGLQE-----EGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
D+ + ++ RLQ + + + L + + + L E+P Q ++ QLS
Sbjct: 6606 -PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLL 6664
Query: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLE-LRQWIVVT---TQKLEAHRGEAGPGDAE 684
++A Q +++ RQS+ + C HQL + L W+ QK +A P
Sbjct: 6665 WEAAQGAVDSWRGGLRQSLMQ-CQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 6723
Query: 685 SQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALR-LL 743
E +L E E++ Q+ +++ ++ K E +E++ + + + LR +
Sbjct: 6724 ECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQV 6783
Query: 744 EESLLSLIRNWHLQRM-----EVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQE 798
+ L++L + EVDSG + P +P R + ++
Sbjct: 6784 SQDLMALQGTQNPASPLPSFDEVDSGDQ--------------PPATSVPAPRAKFRAVRT 6829
Query: 799 EEGSHEDFSQL 809
EG E S++
Sbjct: 6830 TEGEEETESRV 6840
Score = 32.7 bits (73), Expect = 1.7
Identities = 77/384 (20%), Positives = 153/384 (39%), Gaps = 53/384 (13%)
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQE--GLQ 360
+ ++ LE +A + L+ L +++ +IK+L +L + + LQ+ E G
Sbjct: 4608 DNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQS 4667
Query: 361 PAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 420
A + D + A L E R+ A L+E+ + L+ + DS+
Sbjct: 4668 VAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV----YKLEDVLDSM---- 4719
Query: 421 QEYQSLKVKSARLRNAAAVELWQH--FQRPLQDLQLWKA-LAQRLLEVTASLPDLPSLHT 477
+ L+ + L + E Q Q ++ +++ K LA L+ T S L +
Sbjct: 4720 --WGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA--- 4774
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
QIE + +L + ++Q ++ Q R T EQV + +L
Sbjct: 4775 ---QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVT----EVKILEEKSR 4827
Query: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKL-----------------LDLQVRVQAEKGLQRD 580
Q KLQSLL + ++F + L++ L L R+ + ++R+
Sbjct: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Query: 581 LPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLV 640
+ GK A RL EG L A + P + ++ +L + +L + ++ +
Sbjct: 4888 IGGKHA---RLYQTLNEGKQLVASVSC--------PELEGQIAKLEEQWLSLNKKIDHEL 4936
Query: 641 DRCRQSVQEHCTFSHQLLELRQWI 664
R + ++ +++ +L +W+
Sbjct: 4937 HRLQALLKHLLSYNRDSDQLTKWL 4960
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 96.7 bits (239), Expect = 1e-19
Identities = 81/341 (23%), Positives = 164/341 (48%), Gaps = 15/341 (4%)
Query: 5 PQDD--FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVD 62
P +D F+ D W+K +++ L V ++++G + LE R+ + ++I L+PEG R++
Sbjct: 2040 PTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEG-KMPLEERIQKIKEIILLKPEGDARIE 2098
Query: 63 LVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+++ AE+ + P + L DI QW+ T+ + S E + L +YL ++
Sbjct: 2099 TIMKQAES-------SEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSK 2151
Query: 123 DEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN 182
++ ++ E LQ GL+EK+ QL + L + LL L + L
Sbjct: 2152 EDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLE 2211
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEK 242
+PS E+ +K ++++ + Q V L+ REH+ YQ V + L ++
Sbjct: 2212 CTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKE 2271
Query: 243 VNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGE 301
+ ++ + ++L LQ++ + +L+ + + V +NTS +G + I +
Sbjct: 2272 FVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDD 2331
Query: 302 LEEM---RKVLE-KLRALWEEEEERLRGLLRSRGAWEQQIK 338
++ + +K LE +L + +E E L +L+S+ + E++ K
Sbjct: 2332 IKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGK 2372
Score = 82.0 bits (201), Expect = 2e-15
Identities = 95/347 (27%), Positives = 148/347 (42%), Gaps = 22/347 (6%)
Query: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 6548 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 6604
Query: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQR 758
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 6605 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 6663
Query: 759 MEVDSGKK-----MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQEEEGSHEDFSQLLRN 812
+ + + N + + +P DP R L+Q E+ E Q+
Sbjct: 6664 QDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV--- 6720
Query: 813 FGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQHLFENLLRLGPARGT 871
++ NS L++ AE+ + + KL++L +V + + +
Sbjct: 6721 -DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPS 6779
Query: 872 SDELE--DLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRGLGSLFRRACCVALP 929
DE++ D + + K + T E T + R S R ALP
Sbjct: 6780 FDEVDSGDQPPATSVPAPRAKQFRAVRTTEGE-EETESRVPGSTRPQRSFLSRVVRAALP 6838
Query: 930 LQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPPT 975
LQLLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPPT
Sbjct: 6839 LQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 6885
Score = 49.7 bits (117), Expect = 1e-05
Identities = 156/863 (18%), Positives = 329/863 (38%), Gaps = 153/863 (17%)
Query: 11 RSVEDAQAWMKAVQDQLQVNDNTQGPRAALEAR-LWETEKICQLEPEGRVRVDLVLRMAE 69
+++ + +WM V+ Q D+ P +A + + L + K ++E + + + + +
Sbjct: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 70 ALLACCPGDQK----PGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEF 125
L+ C + K L ++ QW H + H + L + E
Sbjct: 5123 LQLSTCDVESKRYERTEFAEHLGEMNRQWHRV-------HGMLNRKIQHLEQLLESITES 5175
Query: 126 YRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL--HNVDNQAVLLDRLLEEAASLFNR 183
Q + LE E L++ + +S ++LL +++NQ + + L+E +
Sbjct: 5176 ENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLT 5235
Query: 184 IGDPSVD--EDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVE 241
+ +V ED R+ + QKR +L QV + Q+ + E++++ + +
Sbjct: 5236 LESGAVPLLEDTASRIDELF-------QKRSSVLTQVNQLKTSMQSVLQEWKIY-DQLYD 5287
Query: 242 KVNG-------CLGRNCKLPIT--------QRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
+VN C+ + + ++ + L +LQD A+ E L+ + + G+
Sbjct: 5288 EVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGL 5347
Query: 287 IRNTSPLGAEK--------------ITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGA 332
+ + + EK I +L++ + +L+ +A E L +
Sbjct: 5348 CPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAK 5407
Query: 333 WEQ--------------------QIKQLEAELSEFR-------MVLQRLAQ--------- 356
++Q IK+L+ ++ + + VL RL Q
Sbjct: 5408 FQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHML 5467
Query: 357 -----EGLQPAA--------KAGTEDELVAHWR----RYSATRAALASEEPRVDRLQAQL 399
LQ AA KA + +++ ++ R + + + EE +DRL Q
Sbjct: 5468 LPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQE 5527
Query: 400 KE-----------LIVFPHNLK---------PLSDSVIATIQEY--QSLKVKSARLRNAA 437
KE L +++ PLSD + T+Q Q ++ + L +
Sbjct: 5528 KENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCS 5587
Query: 438 AVELWQHFQRPLQDLQLWKALAQRL-----LEVTASLPDLPSLHTFLPQIEAALMESSRL 492
++ ++ L + W L +++ ++V SLP+L +EA + + +
Sbjct: 5588 ELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTI 5647
Query: 493 KELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKD 552
+ L+ LL + R + E + R ++ + + QRK + L+ Q +D
Sbjct: 5648 ADSYVTQSLQ--LLDTTEIENRPEFITEFSKLTDRWQNAVQG-VRQRKGDVDGLVRQWQD 5704
Query: 553 FGAAFEPLQRKLLDLQVRVQAEKGLQR-----------DLPGKQAQLSRLQGLQEEGLDL 601
F + E L R L D + A KG +R +L K+ R + L+
Sbjct: 5705 FTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEA 5764
Query: 602 GAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELR 661
G ++ L + + ++ QL ++ ++ L +++ + + +V+ ++ EL+
Sbjct: 5765 GEKLLLTTDL-KTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELK 5823
Query: 662 QWIVVTTQKLEAHRGEAGPGDAESQE--AEFERLVAEFPEKEAQLSLVEAQGWLVMEKSS 719
+ V + E E +E E E+ +A + + +L ++A +
Sbjct: 5824 SRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKAD---LTRHVL 5880
Query: 720 PEGAAVVQEELRELAESWRALRL 742
E V++E++ L W L L
Sbjct: 5881 VEDVMVLKEQIEHLHRQWEDLCL 5903
Score = 45.4 bits (106), Expect = 3e-04
Identities = 122/659 (18%), Positives = 243/659 (36%), Gaps = 94/659 (14%)
Query: 136 LEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQK 195
L+ H E ++ + KQW + L + V R E +G+
Sbjct: 5098 LQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRY--ERTEFAEHLGE--------- 5146
Query: 196 RMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPI 255
M ++ V +++ LEQ+ E + + WL+A E++ + +
Sbjct: 5147 -MNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISV 5205
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRAL 315
+ L QDI ++L+ L++ + PL E ++E+ + +
Sbjct: 5206 QKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVPL-LEDTASRIDELFQKRSSVLTQ 5264
Query: 316 WEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHW 375
+ + ++ +L+ ++Q ++ F ++ L + + L
Sbjct: 5265 VNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVL-------SLETLRCQV 5317
Query: 376 RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQE-YQSLKVKSARLR 434
+ + S E ++LQ + + LK L SV I+E Q+ + ++
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGK-------LKGLCPSVAEIIEEKCQNTHKRWTQVN 5370
Query: 435 NAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKE 494
A A +L Q+ LQLWKA + E A L + L I M + L E
Sbjct: 5371 QAIADQL----QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANIS---MSGNNLAE 5423
Query: 495 LL-TMLQLKKDLLIGIFGQERA-------------------TALLEQVAGSMRDRDLLHN 534
+L LQ K+L + + A LL S++ L
Sbjct: 5424 ILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 535 SLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGL 594
LL + ++ + +L+Q KDFG VR+++ KGL + ++ L RL
Sbjct: 5484 MLLVKANEFEFVLSQFKDFG--------------VRLESLKGL---IMHEEENLDRLHQQ 5526
Query: 595 QEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFS 654
++E D + + L ++P+ +H ++++S +++ L + RQ ++ T
Sbjct: 5527 EKENPD--SFLNHVLALTAQSPDIEH-LNEVSLKLPLSDVAVKTLQNMNRQWIRATATAL 5583
Query: 655 HQLLELR-------------QWIVVTTQKLEAHRGEAGPGDAE--SQEAEFERLVAEFPE 699
+ EL+ +WI + + EA + + E Q+ ++ L AE
Sbjct: 5584 ERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 700 KEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESW----RALRLLEESLLSLIRNW 754
+ Q +++ + E E +L + W + +R + + L+R W
Sbjct: 5644 NQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQW 5702
Score = 40.4 bits (93), Expect = 0.008
Identities = 57/313 (18%), Positives = 127/313 (40%), Gaps = 20/313 (6%)
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
+Y V +A+ R L + + EEY + + W++ + + ++
Sbjct: 3765 QYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHA 3824
Query: 260 STLQDIAKDFPRGEESLET--LEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
ST+Q +D + L + ++ + +I T +++T ++E+ + L+
Sbjct: 3825 STVQMALEDSEQKHNLLHSIFMDLEDLSIIFET-----DELTQSIQELSNQVTALQQKIM 3879
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
E +++ + A E ++K +E +S+ + +L P + ++ + R
Sbjct: 3880 ESLPQIQRMADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRP 3939
Query: 378 YSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSD-SVIATIQEYQSLKVKSARLRNA 436
T A + S + + Q +K L VF + L D ++ + + Q+ +K +
Sbjct: 3940 MKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTN 3999
Query: 437 AAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELL 496
E ++ ++ L + +L + LP L Q E ME K++L
Sbjct: 4000 EWDEEIENLKQILNNYSAQFSLEHMSPDQADKLPQL--------QGEIERME----KQIL 4047
Query: 497 TMLQLKKDLLIGI 509
++ Q K+DLL+ +
Sbjct: 4048 SLNQRKEDLLVDL 4060
Score = 39.7 bits (91), Expect = 0.014
Identities = 53/316 (16%), Positives = 118/316 (37%), Gaps = 20/316 (6%)
Query: 10 DRSVEDAQAWMKAVQDQLQ------VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
D+++ + + W+ ++ +L V D+ + ++ RL E + + + + V+
Sbjct: 6028 DKNMSNLRTWLARIESELSKPVVYDVCDDQE-----IQKRLAEQQDLQRDIEQHSAGVES 6082
Query: 64 VLRMAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYL 119
V + + LL AC + I + + +W +IE W W ++L
Sbjct: 6083 VFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFL 6142
Query: 120 LARDEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEE 176
F W + T P+ L KE+ + Q +H Q L+++
Sbjct: 6143 DDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRR 6202
Query: 177 AASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWL 236
A NR S + +D ++ + + L + EE++ + +WL
Sbjct: 6203 LAR-ENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRESILVWL 6261
Query: 237 KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE 296
+ ++ + + ++ L ++ ++ L +I+ + PL A
Sbjct: 6262 TEMDLQLTN-VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAV 6320
Query: 297 KITGELEEMRKVLEKL 312
I ELEE+ + +++
Sbjct: 6321 LIEDELEELHRYCQEV 6336
Score = 37.0 bits (84), Expect = 0.090
Identities = 50/237 (21%), Positives = 103/237 (43%), Gaps = 16/237 (6%)
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQ-HKDFGAAFEPLQRKLLDLQVRVQAEKG 576
+ EQ +G+ +++ L K K++ L Q + D A L++ +L++ A+
Sbjct: 6524 ITEQQSGAFDRWEMIQAQELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKP- 6582
Query: 577 LQRDLPGKQAQLSRLQGLQE-----EGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
D+ + ++ RLQ + + + L + + + L E+P Q ++ QLS
Sbjct: 6583 -PSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLL 6641
Query: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLE-LRQWIVVT---TQKLEAHRGEAGPGDAE 684
++A Q +++ RQS+ + C HQL + L W+ QK +A P
Sbjct: 6642 WEAAQGAVDSWRGGLRQSLMQ-CQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALL 6700
Query: 685 SQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALR 741
E +L E E++ Q+ +++ ++ K E +E++ + + + LR
Sbjct: 6701 ECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLR 6757
Score = 32.7 bits (73), Expect = 1.7
Identities = 77/384 (20%), Positives = 153/384 (39%), Gaps = 53/384 (13%)
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQE--GLQ 360
+ ++ LE +A + L+ L +++ +IK+L +L + + LQ+ E G
Sbjct: 4608 DNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQS 4667
Query: 361 PAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATI 420
A + D + A L E R+ A L+E+ + L+ + DS+
Sbjct: 4668 VAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEV----YKLEDVLDSM---- 4719
Query: 421 QEYQSLKVKSARLRNAAAVELWQH--FQRPLQDLQLWKA-LAQRLLEVTASLPDLPSLHT 477
+ L+ + L + E Q Q ++ +++ K LA L+ T S L +
Sbjct: 4720 --WGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQA--- 4774
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
QIE + +L + ++Q ++ Q R T EQV + +L
Sbjct: 4775 ---QIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVT----EVKILEEKSR 4827
Query: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKL-----------------LDLQVRVQAEKGLQRD 580
Q KLQSLL + ++F + L++ L L R+ + ++R+
Sbjct: 4828 QCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRN 4887
Query: 581 LPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLV 640
+ GK A RL EG L A + P + ++ +L + +L + ++ +
Sbjct: 4888 IGGKHA---RLYQTLNEGKQLVASVSC--------PELEGQIAKLEEQWLSLNKKIDHEL 4936
Query: 641 DRCRQSVQEHCTFSHQLLELRQWI 664
R + ++ +++ +L +W+
Sbjct: 4937 HRLQALLKHLLSYNRDSDQLTKWL 4960
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 80.5 bits (197), Expect = 7e-15
Identities = 182/930 (19%), Positives = 384/930 (41%), Gaps = 117/930 (12%)
Query: 19 WMKAVQDQLQ---VND-NTQGPRAALEARLWETEKICQLEPEG----RVRVDLVLRMAEA 70
W+ V D+L V D +T+G LW+ + ++ E + VD L
Sbjct: 3568 WLNEVHDKLSKLSVQDYSTEG--------LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3619
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
LL GD+ I +L+ IKA++++ T +E +E W
Sbjct: 3620 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3679
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD 190
K+ V L + L +E + L N LLD L E +++L + P
Sbjct: 3680 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV--PWRA 3737
Query: 191 EDAQKRMKAE----YDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++M AE Y V ++V+ ++ +++ D W+ +K+
Sbjct: 3738 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS- 3796
Query: 247 LGRNCKLPITQRLSTLQDIAKDFP----RGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
LG + +L Q + LQ + K F R ++ ++ L + ++ S + + +L
Sbjct: 3797 LG-DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3854
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGA----WEQQIKQLEAELSEFRMVLQRLAQEG 358
+ KVL+ + + ER L R++ WE ++L L+E + ++ +L
Sbjct: 3855 D---KVLKNYDTICQINSERYLQLERAQSLVNQFWETY-EELWPWLTETQSIISQLPAPA 3910
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI-VFPHNLKPLSDSVI 417
L+ ++E + R +A +P +D++ +L+ + P + + +
Sbjct: 3911 LEYETLRQQQEE-------HRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3963
Query: 418 ATIQEYQSLKV---KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPS 474
A Y +K K A + A + Q + Q L+ + + +RL + + ++
Sbjct: 3964 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK 4023
Query: 475 LHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE----RATALLEQVAGSMRDRD 530
+ + + + ++ +L+ L L+ + + +I G A A+ +++ + +
Sbjct: 4024 IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE 4083
Query: 531 LLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ--VRVQAEKGLQRDLPGKQAQL 588
+H + +R++KL ++ + F L + D Q +R + G+ + +Q +
Sbjct: 4084 NIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEA 4143
Query: 589 SR-----LQGLQEE---GLDLGAQMEAA-----RPLVQENPNHQHKMDQLSSDFQALQRS 635
+ + GLQEE ++LG+++ AA +P+V+++ +D+L+S + +L ++
Sbjct: 4144 AETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS------IDELNSAWDSLNKA 4197
Query: 636 LEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG--DAESQEAEFERL 693
+D +D+ +++Q + L + W+ + KL A G + Q E ++
Sbjct: 4198 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL-ASMSPIGTDLETVKQQIEELKQF 4256
Query: 694 VAEFPEKEAQLSLVEAQGWLVMEKSSPEG-AAVVQEELRELAESWRAL--------RLLE 744
+E +++ ++ + Q L+++K + E VQ+ L EL W +L LE
Sbjct: 4257 KSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLE 4316
Query: 745 ESLLSLIRNWHL--QRMEVDSGKKMVFTNNIPKSGFLINPMDP--IPRHRRRANLLQEEE 800
+LL+L + H + + + + + + P G DP I + ++LQ +
Sbjct: 4317 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGG------DPKAIEIELAKHHVLQNDV 4370
Query: 801 GSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEAR-------VP 853
+H+ + + G L + +S E+ ++KL+ L R
Sbjct: 4371 LAHQSTVEAVNKAGNDL------------IESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418
Query: 854 EGQHLFENLLRLGPARGTSDELEDLRYQWM 883
+ + + LR A+G E+EDL+ QW+
Sbjct: 4419 QRKQQLDGALR--QAKGFHGEIEDLQ-QWL 4445
Score = 60.8 bits (146), Expect = 6e-09
Identities = 138/639 (21%), Positives = 251/639 (39%), Gaps = 97/639 (15%)
Query: 136 LEPHIELQLGLKEK----QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD---PS 188
LE ++ Q+G ++ Q+Q AQ +QAV++ + A L + G P
Sbjct: 1774 LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVII--ATQSAQVLLEKQGQYLSPE 1831
Query: 189 VDEDAQKRMK---AEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
E QK MK Y+ A+++K++ L + E E++ A EF+ WL+
Sbjct: 1832 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQ-------- 1883
Query: 246 CLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
Q L L+ A D L+ + S VI + L I+G
Sbjct: 1884 --------QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISG----- 1930
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+VLE ++ +R G + + + ++L+ FR + + G
Sbjct: 1931 NRVLEAAKSC----SKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG------- 1979
Query: 366 GTEDELVAHWRRY-SATRAALASEEPRVDRLQAQLKE-LIVFPHNLKPLSDSVIATIQEY 423
+LV ++ Y A+ LA + L E + V P NL+ + A +
Sbjct: 1980 NNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQI 2039
Query: 424 QSLKVKSARLRNAAAVEL---------WQHFQRPLQDL-----QLWKALAQR----LLEV 465
S +V +L+ A V L Q+ L D+ L K++ +R + +
Sbjct: 2040 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2099
Query: 466 TASL---PDLPSLHTFLPQIEAALMESSRLKELLTMLQ--LKKDLLI--GIFG-QERATA 517
T SL L + ++ +E++L E ++ T LQ + K++++ I G Q A
Sbjct: 2100 TRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA 2159
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSK-----LQSLLAQHKDFGAAFEPLQRKL-------- 564
+ E+V M D S LQ K K +HK+ A E L+ K+
Sbjct: 2160 MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2219
Query: 565 -LDLQVRVQAEKGLQRDLPGKQ-AQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNH--- 618
L + + + + D+PGK +LS+ +Q E L+ +E L++E +H
Sbjct: 2220 KLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLP 2279
Query: 619 ------QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
K + LS F+ ++ ++++ + ++ F + L+ WI TT+K+
Sbjct: 2280 SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVP 2339
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQG 711
+ G D + ++L ++ K ++ V G
Sbjct: 2340 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2378
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 23/522 (4%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F +ED Q W+ + L + G + +L ++C +++
Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4493
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ +LA CP + I + ++K +WE T + +++E E+ + +F W
Sbjct: 4494 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4553
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL--FNRIGD 186
+ TL L L +Q+ +V + V++ + L + L F++ D
Sbjct: 4554 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4613
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++ +++ ++ V + +R L+ + +++ + WL+ + ++
Sbjct: 4614 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4673
Query: 247 LG-RNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE-KITGELEE 304
L N I +L+ ++ K +T + TS K+ L E
Sbjct: 4674 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4733
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+R + + E + +L L G Q L+A + V +LA++ QP
Sbjct: 4734 LRDKWDTICGKSVERQNKLEEALLFSG---QFTDALQALIDWLYRVEPQLAED--QPV-- 4786
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
G D ++ + A + L V L+ +ELI + S V +QE
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQMQELS 4843
Query: 425 -------SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLH 476
+L + S + R AA+ + F + L W A A++ L LP D +L
Sbjct: 4844 TRWETVCALSI-SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4902
Query: 477 TFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
T + Q + + + + L D ++ I + T +
Sbjct: 4903 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944
Score = 46.6 bits (109), Expect = 1e-04
Identities = 120/663 (18%), Positives = 243/663 (36%), Gaps = 91/663 (13%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMK---AEYD 202
K Q QL + L + +Q V +++L + A L + G D QK + Y+
Sbjct: 2023 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2082
Query: 203 AVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTL 262
+ +R + L+ Q G+DE W+ V L ++P+ + L
Sbjct: 2083 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG----NVESSLKEQGQVPLNS--TAL 2136
Query: 263 QDIA-------KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM---------- 305
QDI +D + S+ + E+ + T P A + +++++
Sbjct: 2137 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2196
Query: 306 -RKVLEKLRAL------WEEEEERLRGLLRSR----------GAWEQQIKQ-LEAELSEF 347
++ L K+ L +E E+L+ L ++ G ++ Q ++ SEF
Sbjct: 2197 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2256
Query: 348 ----------RMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQA 397
+L+ ++ GL P+ KA ++ +++ + ++ V Q
Sbjct: 2257 LEHKKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2315
Query: 398 QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
QL V +LK + Q + A +L + + + + W
Sbjct: 2316 QLDAFQVLVKSLKSWIKETTKKVPIVQP---------SFGAEDLGKSLEDTKKLQEKWSL 2366
Query: 458 LAQRLLEVT---ASLPDLPSLHTFLPQIEAALME----------SSRLKELLT---MLQL 501
+ +V SL +L S T + AA+ ++ +E + +
Sbjct: 2367 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
KKD+ G E LL+ + + + S + L + ++
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHK 621
V+ Q E+ + KQ ++++Q L+++ +L + P E P +
Sbjct: 2487 APTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEE----NPDTPEAPRWKQM 2541
Query: 622 MDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG--EAG 679
+ ++ S +Q L + D + +S F +L+QW+ V + + + G
Sbjct: 2542 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL-VEKELMVSVLGPLSID 2600
Query: 680 PGDAESQEAEFERLVAEFPEKEAQLSLVEA--QGWLVMEKSSPEGAAVVQEELRELAESW 737
P +Q + + L+ EF ++ Q + A QG L P +V+E+L + + W
Sbjct: 2601 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2660
Query: 738 RAL 740
+L
Sbjct: 2661 DSL 2663
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/578 (19%), Positives = 219/578 (37%), Gaps = 72/578 (12%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
V+ KA+ V L+ ++Q +FQ WL E+ +N PI+ +L L+
Sbjct: 2773 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEE------QNKSHPISAKLDVLE 2826
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE------ 317
+ KD ++L I L + E ++ L ++ W+
Sbjct: 2827 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2886
Query: 318 -EEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRMVLQRLAQEGLQPAAK-AGTE 368
E E +L+ L +++Q++ L + L E + L EG AK +
Sbjct: 2887 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQ 2944
Query: 369 DELVAHW---RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQS 425
E+ H+ + T +L S ++ + +V N K L V ++ S
Sbjct: 2945 KEMDQHFGMVELLNNTANSLLS--------VCEIDKEVVTDEN-KSLIQKVDMVTEQLHS 2995
Query: 426 LKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K L N + ++ FQ ++ + A+ L++ SL + +L ++
Sbjct: 2996 ---KKFCLEN--MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050
Query: 486 LMESSRLKELLTML-QLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
LK + + +L +DL++ + + +L QV ++ L + ++ S L+
Sbjct: 3051 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3110
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
+ L F + + + + + + RD Q Q ++ ++ L A
Sbjct: 3111 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK---LEAL 3167
Query: 605 MEAARPLVQENPNHQHKM----DQLSSDFQALQRSLEDLVDRCR------QSVQEHCTFS 654
M + +N N KM ++ S D ++R LE L +C Q+ +E +
Sbjct: 3168 MAS-----NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3222
Query: 655 HQLLE-----LRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
+ LE L+++ ++ QK E H GP E++ + + + +KE L
Sbjct: 3223 IKRLEEFYSKLKEFSIL-LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3281
Query: 710 Q---GW----LVMEKSSPEGAAVVQEELRELAESWRAL 740
Q W L+ + ++ +L ++ W+ L
Sbjct: 3282 QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3319
Score = 42.7 bits (99), Expect = 0.002
Identities = 119/646 (18%), Positives = 254/646 (39%), Gaps = 73/646 (11%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +WM ++ + ++A++ E + + +L + + V+++ R
Sbjct: 3340 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3399
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
E + K IL +L + ++WE + + ++E + + + E L +E+
Sbjct: 3400 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3459
Query: 126 YRWFQKMMVTLEPHIELQLGLKEK--QWQLSHAQVLLHNVD-NQAVLLDRLLEEAASLFN 182
+K +V EP L+E+ Q + ++ HN +QAV + + L+ +S
Sbjct: 3460 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR-- 3517
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVV 240
D + + + Y ++ K+ R +LL+Q + + G DE +L WL V
Sbjct: 3518 --EDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIF--GEDEVELMNWLNEVH 3573
Query: 241 EKVN----------GCLGRNCKLPITQR--LSTLQDIAKDFPRGEESLETLEEQSAGVIR 288
+K++ G + +L + Q L Q++ + G E L+ +I+
Sbjct: 3574 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3633
Query: 289 NTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFR 348
+ E I +++ K+ + E+ + R L + + ++E EL +
Sbjct: 3634 DK----LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3689
Query: 349 MVL---QRLAQEGLQP---AAKAGTEDELVAHWRRYSATRAALASEEPR--VDRLQAQLK 400
+ + +Q ++P +A L+ S+ L R ++++ A+
Sbjct: 3690 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3749
Query: 401 ELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL-W-QHFQRPLQDLQLWKAL 458
E + +SD++ ++E + ++S + AA EL W ++ L +L
Sbjct: 3750 E------RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM------SL 3797
Query: 459 AQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
LE + L TF ME R K+++ L ++ +E ++
Sbjct: 3798 GDIRLEQDQTSAQLQVQKTF-------TMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3850
Query: 519 LEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ 578
+++ +++ D + +R +L+ + F +E L L + Q +
Sbjct: 3851 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ-------SII 3903
Query: 579 RDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQ 624
LP + L+ QEE L R L+ E+ H KM++
Sbjct: 3904 SQLPAPALEYETLRQQQEEHRQL-------RELIAEHKPHIDKMNK 3942
Score = 37.7 bits (86), Expect = 0.053
Identities = 85/431 (19%), Positives = 171/431 (39%), Gaps = 64/431 (14%)
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
L + ++ + G ++ L LK + ++N +LS LQ ++ +
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELN------------TKLSKLQKAQEESSAMMQ 2470
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRA---LWEEEEERLRGLLRSRG 331
L+ + + + + +P E + ++E+ + +L+ +E +++L LL
Sbjct: 2471 WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP 2530
Query: 332 ------AWEQQIKQLEA---ELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATR 382
W+Q + ++++ EL++ + Q+ +E + T + + W
Sbjct: 2531 DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW------- 2583
Query: 383 AALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW 442
L +E V + L L + P+ L V +QE+ + K + +L A L
Sbjct: 2584 --LVEKELMV----SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL- 2636
Query: 443 QHFQRPLQDLQLWKALAQRLLEVTASLPDLPS-LHTFLPQIEAALMESSRLKELLTMLQL 501
RP +D L + ++L VT L L I+ A+++S++ + LL L
Sbjct: 2637 ---SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS- 2692
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
D L + + ++ + +M N L+ K++ + Q K + Q
Sbjct: 2693 --DKLSDLDNKLSSSLAVSTHPDAM-------NQQLETAQKMKQEIQQEKK---QIKVAQ 2740
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNHQH 620
DL V+ E +A+LSR L+G+ + D+ + E +Q H
Sbjct: 2741 ALCEDLSALVKEEY--------LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2792
Query: 621 KMDQLSSDFQA 631
+ Q+S DFQA
Sbjct: 2793 QFQQMSRDFQA 2803
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 80.5 bits (197), Expect = 7e-15
Identities = 182/930 (19%), Positives = 384/930 (41%), Gaps = 117/930 (12%)
Query: 19 WMKAVQDQLQ---VND-NTQGPRAALEARLWETEKICQLEPEG----RVRVDLVLRMAEA 70
W+ V D+L V D +T+G LW+ + ++ E + VD L
Sbjct: 3579 WLNEVHDKLSKLSVQDYSTEG--------LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
LL GD+ I +L+ IKA++++ T +E +E W
Sbjct: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD 190
K+ V L + L +E + L N LLD L E +++L + P
Sbjct: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV--PWRA 3748
Query: 191 EDAQKRMKAE----YDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++M AE Y V ++V+ ++ +++ D W+ +K+
Sbjct: 3749 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS- 3807
Query: 247 LGRNCKLPITQRLSTLQDIAKDFP----RGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
LG + +L Q + LQ + K F R ++ ++ L + ++ S + + +L
Sbjct: 3808 LG-DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGA----WEQQIKQLEAELSEFRMVLQRLAQEG 358
+ KVL+ + + ER L R++ WE ++L L+E + ++ +L
Sbjct: 3866 D---KVLKNYDTICQINSERYLQLERAQSLVNQFWETY-EELWPWLTETQSIISQLPAPA 3921
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI-VFPHNLKPLSDSVI 417
L+ ++E + R +A +P +D++ +L+ + P + + +
Sbjct: 3922 LEYETLRQQQEE-------HRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3974
Query: 418 ATIQEYQSLKV---KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPS 474
A Y +K K A + A + Q + Q L+ + + +RL + + ++
Sbjct: 3975 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK 4034
Query: 475 LHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE----RATALLEQVAGSMRDRD 530
+ + + + ++ +L+ L L+ + + +I G A A+ +++ + +
Sbjct: 4035 IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE 4094
Query: 531 LLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ--VRVQAEKGLQRDLPGKQAQL 588
+H + +R++KL ++ + F L + D Q +R + G+ + +Q +
Sbjct: 4095 NIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEA 4154
Query: 589 SR-----LQGLQEE---GLDLGAQMEAA-----RPLVQENPNHQHKMDQLSSDFQALQRS 635
+ + GLQEE ++LG+++ AA +P+V+++ +D+L+S + +L ++
Sbjct: 4155 AETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS------IDELNSAWDSLNKA 4208
Query: 636 LEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG--DAESQEAEFERL 693
+D +D+ +++Q + L + W+ + KL A G + Q E ++
Sbjct: 4209 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL-ASMSPIGTDLETVKQQIEELKQF 4267
Query: 694 VAEFPEKEAQLSLVEAQGWLVMEKSSPEG-AAVVQEELRELAESWRAL--------RLLE 744
+E +++ ++ + Q L+++K + E VQ+ L EL W +L LE
Sbjct: 4268 KSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLE 4327
Query: 745 ESLLSLIRNWHL--QRMEVDSGKKMVFTNNIPKSGFLINPMDP--IPRHRRRANLLQEEE 800
+LL+L + H + + + + + + P G DP I + ++LQ +
Sbjct: 4328 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGG------DPKAIEIELAKHHVLQNDV 4381
Query: 801 GSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEAR-------VP 853
+H+ + + G L + +S E+ ++KL+ L R
Sbjct: 4382 LAHQSTVEAVNKAGNDL------------IESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
Query: 854 EGQHLFENLLRLGPARGTSDELEDLRYQWM 883
+ + + LR A+G E+EDL+ QW+
Sbjct: 4430 QRKQQLDGALR--QAKGFHGEIEDLQ-QWL 4456
Score = 60.8 bits (146), Expect = 6e-09
Identities = 138/639 (21%), Positives = 251/639 (39%), Gaps = 97/639 (15%)
Query: 136 LEPHIELQLGLKEK----QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD---PS 188
LE ++ Q+G ++ Q+Q AQ +QAV++ + A L + G P
Sbjct: 1785 LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVII--ATQSAQVLLEKQGQYLSPE 1842
Query: 189 VDEDAQKRMK---AEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
E QK MK Y+ A+++K++ L + E E++ A EF+ WL+
Sbjct: 1843 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQ-------- 1894
Query: 246 CLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
Q L L+ A D L+ + S VI + L I+G
Sbjct: 1895 --------QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISG----- 1941
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+VLE ++ +R G + + + ++L+ FR + + G
Sbjct: 1942 NRVLEAAKSC----SKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG------- 1990
Query: 366 GTEDELVAHWRRY-SATRAALASEEPRVDRLQAQLKE-LIVFPHNLKPLSDSVIATIQEY 423
+LV ++ Y A+ LA + L E + V P NL+ + A +
Sbjct: 1991 NNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQI 2050
Query: 424 QSLKVKSARLRNAAAVEL---------WQHFQRPLQDL-----QLWKALAQR----LLEV 465
S +V +L+ A V L Q+ L D+ L K++ +R + +
Sbjct: 2051 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2110
Query: 466 TASL---PDLPSLHTFLPQIEAALMESSRLKELLTMLQ--LKKDLLI--GIFG-QERATA 517
T SL L + ++ +E++L E ++ T LQ + K++++ I G Q A
Sbjct: 2111 TRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA 2170
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSK-----LQSLLAQHKDFGAAFEPLQRKL-------- 564
+ E+V M D S LQ K K +HK+ A E L+ K+
Sbjct: 2171 MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
Query: 565 -LDLQVRVQAEKGLQRDLPGKQ-AQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNH--- 618
L + + + + D+PGK +LS+ +Q E L+ +E L++E +H
Sbjct: 2231 KLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLP 2290
Query: 619 ------QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
K + LS F+ ++ ++++ + ++ F + L+ WI TT+K+
Sbjct: 2291 SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVP 2350
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQG 711
+ G D + ++L ++ K ++ V G
Sbjct: 2351 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 23/522 (4%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F +ED Q W+ + L + G + +L ++C +++
Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ +LA CP + I + ++K +WE T + +++E E+ + +F W
Sbjct: 4505 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL--FNRIGD 186
+ TL L L +Q+ +V + V++ + L + L F++ D
Sbjct: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++ +++ ++ V + +R L+ + +++ + WL+ + ++
Sbjct: 4625 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4684
Query: 247 LG-RNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE-KITGELEE 304
L N I +L+ ++ K +T + TS K+ L E
Sbjct: 4685 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4744
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+R + + E + +L L G Q L+A + V +LA++ QP
Sbjct: 4745 LRDKWDTICGKSVERQNKLEEALLFSG---QFTDALQALIDWLYRVEPQLAED--QPV-- 4797
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
G D ++ + A + L V L+ +ELI + S V +QE
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQMQELS 4854
Query: 425 -------SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLH 476
+L + S + R AA+ + F + L W A A++ L LP D +L
Sbjct: 4855 TRWETVCALSI-SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4913
Query: 477 TFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
T + Q + + + + L D ++ I + T +
Sbjct: 4914 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
Score = 46.6 bits (109), Expect = 1e-04
Identities = 120/663 (18%), Positives = 243/663 (36%), Gaps = 91/663 (13%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMK---AEYD 202
K Q QL + L + +Q V +++L + A L + G D QK + Y+
Sbjct: 2034 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2093
Query: 203 AVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTL 262
+ +R + L+ Q G+DE W+ V L ++P+ + L
Sbjct: 2094 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG----NVESSLKEQGQVPLNS--TAL 2147
Query: 263 QDIA-------KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM---------- 305
QDI +D + S+ + E+ + T P A + +++++
Sbjct: 2148 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2207
Query: 306 -RKVLEKLRAL------WEEEEERLRGLLRSR----------GAWEQQIKQ-LEAELSEF 347
++ L K+ L +E E+L+ L ++ G ++ Q ++ SEF
Sbjct: 2208 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2267
Query: 348 ----------RMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQA 397
+L+ ++ GL P+ KA ++ +++ + ++ V Q
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2326
Query: 398 QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
QL V +LK + Q + A +L + + + + W
Sbjct: 2327 QLDAFQVLVKSLKSWIKETTKKVPIVQP---------SFGAEDLGKSLEDTKKLQEKWSL 2377
Query: 458 LAQRLLEVT---ASLPDLPSLHTFLPQIEAALME----------SSRLKELLT---MLQL 501
+ +V SL +L S T + AA+ ++ +E + +
Sbjct: 2378 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
KKD+ G E LL+ + + + S + L + ++
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHK 621
V+ Q E+ + KQ ++++Q L+++ +L + P E P +
Sbjct: 2498 APTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEE----NPDTPEAPRWKQM 2552
Query: 622 MDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG--EAG 679
+ ++ S +Q L + D + +S F +L+QW+ V + + + G
Sbjct: 2553 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL-VEKELMVSVLGPLSID 2611
Query: 680 PGDAESQEAEFERLVAEFPEKEAQLSLVEA--QGWLVMEKSSPEGAAVVQEELRELAESW 737
P +Q + + L+ EF ++ Q + A QG L P +V+E+L + + W
Sbjct: 2612 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2671
Query: 738 RAL 740
+L
Sbjct: 2672 DSL 2674
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/578 (19%), Positives = 219/578 (37%), Gaps = 72/578 (12%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
V+ KA+ V L+ ++Q +FQ WL E+ +N PI+ +L L+
Sbjct: 2784 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEE------QNKSHPISAKLDVLE 2837
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE------ 317
+ KD ++L I L + E ++ L ++ W+
Sbjct: 2838 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2897
Query: 318 -EEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRMVLQRLAQEGLQPAAK-AGTE 368
E E +L+ L +++Q++ L + L E + L EG AK +
Sbjct: 2898 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQ 2955
Query: 369 DELVAHW---RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQS 425
E+ H+ + T +L S ++ + +V N K L V ++ S
Sbjct: 2956 KEMDQHFGMVELLNNTANSLLS--------VCEIDKEVVTDEN-KSLIQKVDMVTEQLHS 3006
Query: 426 LKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K L N + ++ FQ ++ + A+ L++ SL + +L ++
Sbjct: 3007 ---KKFCLEN--MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
Query: 486 LMESSRLKELLTML-QLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
LK + + +L +DL++ + + +L QV ++ L + ++ S L+
Sbjct: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3121
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
+ L F + + + + + + RD Q Q ++ ++ L A
Sbjct: 3122 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK---LEAL 3178
Query: 605 MEAARPLVQENPNHQHKM----DQLSSDFQALQRSLEDLVDRCR------QSVQEHCTFS 654
M + +N N KM ++ S D ++R LE L +C Q+ +E +
Sbjct: 3179 MAS-----NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3233
Query: 655 HQLLE-----LRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
+ LE L+++ ++ QK E H GP E++ + + + +KE L
Sbjct: 3234 IKRLEEFYSKLKEFSIL-LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3292
Query: 710 Q---GW----LVMEKSSPEGAAVVQEELRELAESWRAL 740
Q W L+ + ++ +L ++ W+ L
Sbjct: 3293 QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330
Score = 42.7 bits (99), Expect = 0.002
Identities = 119/646 (18%), Positives = 254/646 (39%), Gaps = 73/646 (11%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +WM ++ + ++A++ E + + +L + + V+++ R
Sbjct: 3351 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3410
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
E + K IL +L + ++WE + + ++E + + + E L +E+
Sbjct: 3411 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3470
Query: 126 YRWFQKMMVTLEPHIELQLGLKEK--QWQLSHAQVLLHNVD-NQAVLLDRLLEEAASLFN 182
+K +V EP L+E+ Q + ++ HN +QAV + + L+ +S
Sbjct: 3471 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR-- 3528
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVV 240
D + + + Y ++ K+ R +LL+Q + + G DE +L WL V
Sbjct: 3529 --EDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIF--GEDEVELMNWLNEVH 3584
Query: 241 EKVN----------GCLGRNCKLPITQR--LSTLQDIAKDFPRGEESLETLEEQSAGVIR 288
+K++ G + +L + Q L Q++ + G E L+ +I+
Sbjct: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644
Query: 289 NTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFR 348
+ E I +++ K+ + E+ + R L + + ++E EL +
Sbjct: 3645 DK----LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3700
Query: 349 MVL---QRLAQEGLQP---AAKAGTEDELVAHWRRYSATRAALASEEPR--VDRLQAQLK 400
+ + +Q ++P +A L+ S+ L R ++++ A+
Sbjct: 3701 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3760
Query: 401 ELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL-W-QHFQRPLQDLQLWKAL 458
E + +SD++ ++E + ++S + AA EL W ++ L +L
Sbjct: 3761 E------RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM------SL 3808
Query: 459 AQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
LE + L TF ME R K+++ L ++ +E ++
Sbjct: 3809 GDIRLEQDQTSAQLQVQKTF-------TMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3861
Query: 519 LEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ 578
+++ +++ D + +R +L+ + F +E L L + Q +
Sbjct: 3862 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ-------SII 3914
Query: 579 RDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQ 624
LP + L+ QEE L R L+ E+ H KM++
Sbjct: 3915 SQLPAPALEYETLRQQQEEHRQL-------RELIAEHKPHIDKMNK 3953
Score = 37.7 bits (86), Expect = 0.053
Identities = 85/431 (19%), Positives = 171/431 (39%), Gaps = 64/431 (14%)
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
L + ++ + G ++ L LK + ++N +LS LQ ++ +
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELN------------TKLSKLQKAQEESSAMMQ 2481
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRA---LWEEEEERLRGLLRSRG 331
L+ + + + + +P E + ++E+ + +L+ +E +++L LL
Sbjct: 2482 WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP 2541
Query: 332 ------AWEQQIKQLEA---ELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATR 382
W+Q + ++++ EL++ + Q+ +E + T + + W
Sbjct: 2542 DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW------- 2594
Query: 383 AALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW 442
L +E V + L L + P+ L V +QE+ + K + +L A L
Sbjct: 2595 --LVEKELMV----SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL- 2647
Query: 443 QHFQRPLQDLQLWKALAQRLLEVTASLPDLPS-LHTFLPQIEAALMESSRLKELLTMLQL 501
RP +D L + ++L VT L L I+ A+++S++ + LL L
Sbjct: 2648 ---SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS- 2703
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
D L + + ++ + +M N L+ K++ + Q K + Q
Sbjct: 2704 --DKLSDLDNKLSSSLAVSTHPDAM-------NQQLETAQKMKQEIQQEKK---QIKVAQ 2751
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNHQH 620
DL V+ E +A+LSR L+G+ + D+ + E +Q H
Sbjct: 2752 ALCEDLSALVKEEY--------LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2803
Query: 621 KMDQLSSDFQA 631
+ Q+S DFQA
Sbjct: 2804 QFQQMSRDFQA 2814
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 80.5 bits (197), Expect = 7e-15
Identities = 182/930 (19%), Positives = 384/930 (41%), Gaps = 117/930 (12%)
Query: 19 WMKAVQDQLQ---VND-NTQGPRAALEARLWETEKICQLEPEG----RVRVDLVLRMAEA 70
W+ V D+L V D +T+G LW+ + ++ E + VD L
Sbjct: 3717 WLNEVHDKLSKLSVQDYSTEG--------LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3768
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
LL GD+ I +L+ IKA++++ T +E +E W
Sbjct: 3769 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3828
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD 190
K+ V L + L +E + L N LLD L E +++L + P
Sbjct: 3829 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV--PWRA 3886
Query: 191 EDAQKRMKAE----YDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++M AE Y V ++V+ ++ +++ D W+ +K+
Sbjct: 3887 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS- 3945
Query: 247 LGRNCKLPITQRLSTLQDIAKDFP----RGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
LG + +L Q + LQ + K F R ++ ++ L + ++ S + + +L
Sbjct: 3946 LG-DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 4003
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGA----WEQQIKQLEAELSEFRMVLQRLAQEG 358
+ KVL+ + + ER L R++ WE ++L L+E + ++ +L
Sbjct: 4004 D---KVLKNYDTICQINSERYLQLERAQSLVNQFWETY-EELWPWLTETQSIISQLPAPA 4059
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI-VFPHNLKPLSDSVI 417
L+ ++E + R +A +P +D++ +L+ + P + + +
Sbjct: 4060 LEYETLRQQQEE-------HRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 4112
Query: 418 ATIQEYQSLKV---KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPS 474
A Y +K K A + A + Q + Q L+ + + +RL + + ++
Sbjct: 4113 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK 4172
Query: 475 LHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE----RATALLEQVAGSMRDRD 530
+ + + + ++ +L+ L L+ + + +I G A A+ +++ + +
Sbjct: 4173 IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE 4232
Query: 531 LLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ--VRVQAEKGLQRDLPGKQAQL 588
+H + +R++KL ++ + F L + D Q +R + G+ + +Q +
Sbjct: 4233 NIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEA 4292
Query: 589 SR-----LQGLQEE---GLDLGAQMEAA-----RPLVQENPNHQHKMDQLSSDFQALQRS 635
+ + GLQEE ++LG+++ AA +P+V+++ +D+L+S + +L ++
Sbjct: 4293 AETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS------IDELNSAWDSLNKA 4346
Query: 636 LEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG--DAESQEAEFERL 693
+D +D+ +++Q + L + W+ + KL A G + Q E ++
Sbjct: 4347 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL-ASMSPIGTDLETVKQQIEELKQF 4405
Query: 694 VAEFPEKEAQLSLVEAQGWLVMEKSSPEG-AAVVQEELRELAESWRAL--------RLLE 744
+E +++ ++ + Q L+++K + E VQ+ L EL W +L LE
Sbjct: 4406 KSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLE 4465
Query: 745 ESLLSLIRNWHL--QRMEVDSGKKMVFTNNIPKSGFLINPMDP--IPRHRRRANLLQEEE 800
+LL+L + H + + + + + + P G DP I + ++LQ +
Sbjct: 4466 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGG------DPKAIEIELAKHHVLQNDV 4519
Query: 801 GSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEAR-------VP 853
+H+ + + G L + +S E+ ++KL+ L R
Sbjct: 4520 LAHQSTVEAVNKAGNDL------------IESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567
Query: 854 EGQHLFENLLRLGPARGTSDELEDLRYQWM 883
+ + + LR A+G E+EDL+ QW+
Sbjct: 4568 QRKQQLDGALR--QAKGFHGEIEDLQ-QWL 4594
Score = 60.8 bits (146), Expect = 6e-09
Identities = 138/639 (21%), Positives = 251/639 (39%), Gaps = 97/639 (15%)
Query: 136 LEPHIELQLGLKEK----QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD---PS 188
LE ++ Q+G ++ Q+Q AQ +QAV++ + A L + G P
Sbjct: 1923 LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVII--ATQSAQVLLEKQGQYLSPE 1980
Query: 189 VDEDAQKRMK---AEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
E QK MK Y+ A+++K++ L + E E++ A EF+ WL+
Sbjct: 1981 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQ-------- 2032
Query: 246 CLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
Q L L+ A D L+ + S VI + L I+G
Sbjct: 2033 --------QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISG----- 2079
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+VLE ++ +R G + + + ++L+ FR + + G
Sbjct: 2080 NRVLEAAKSC----SKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG------- 2128
Query: 366 GTEDELVAHWRRY-SATRAALASEEPRVDRLQAQLKE-LIVFPHNLKPLSDSVIATIQEY 423
+LV ++ Y A+ LA + L E + V P NL+ + A +
Sbjct: 2129 NNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQI 2188
Query: 424 QSLKVKSARLRNAAAVEL---------WQHFQRPLQDL-----QLWKALAQR----LLEV 465
S +V +L+ A V L Q+ L D+ L K++ +R + +
Sbjct: 2189 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2248
Query: 466 TASL---PDLPSLHTFLPQIEAALMESSRLKELLTMLQ--LKKDLLI--GIFG-QERATA 517
T SL L + ++ +E++L E ++ T LQ + K++++ I G Q A
Sbjct: 2249 TRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA 2308
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSK-----LQSLLAQHKDFGAAFEPLQRKL-------- 564
+ E+V M D S LQ K K +HK+ A E L+ K+
Sbjct: 2309 MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2368
Query: 565 -LDLQVRVQAEKGLQRDLPGKQ-AQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNH--- 618
L + + + + D+PGK +LS+ +Q E L+ +E L++E +H
Sbjct: 2369 KLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLP 2428
Query: 619 ------QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
K + LS F+ ++ ++++ + ++ F + L+ WI TT+K+
Sbjct: 2429 SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVP 2488
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQG 711
+ G D + ++L ++ K ++ V G
Sbjct: 2489 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2527
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 23/522 (4%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F +ED Q W+ + L + G + +L ++C +++
Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4642
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ +LA CP + I + ++K +WE T + +++E E+ + +F W
Sbjct: 4643 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4702
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL--FNRIGD 186
+ TL L L +Q+ +V + V++ + L + L F++ D
Sbjct: 4703 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4762
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++ +++ ++ V + +R L+ + +++ + WL+ + ++
Sbjct: 4763 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4822
Query: 247 LG-RNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE-KITGELEE 304
L N I +L+ ++ K +T + TS K+ L E
Sbjct: 4823 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4882
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+R + + E + +L L G Q L+A + V +LA++ QP
Sbjct: 4883 LRDKWDTICGKSVERQNKLEEALLFSG---QFTDALQALIDWLYRVEPQLAED--QPV-- 4935
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
G D ++ + A + L V L+ +ELI + S V +QE
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQMQELS 4992
Query: 425 -------SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLH 476
+L + S + R AA+ + F + L W A A++ L LP D +L
Sbjct: 4993 TRWETVCALSI-SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 5051
Query: 477 TFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
T + Q + + + + L D ++ I + T +
Sbjct: 5052 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093
Score = 46.6 bits (109), Expect = 1e-04
Identities = 120/663 (18%), Positives = 243/663 (36%), Gaps = 91/663 (13%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMK---AEYD 202
K Q QL + L + +Q V +++L + A L + G D QK + Y+
Sbjct: 2172 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2231
Query: 203 AVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTL 262
+ +R + L+ Q G+DE W+ V L ++P+ + L
Sbjct: 2232 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG----NVESSLKEQGQVPLNS--TAL 2285
Query: 263 QDIA-------KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM---------- 305
QDI +D + S+ + E+ + T P A + +++++
Sbjct: 2286 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2345
Query: 306 -RKVLEKLRAL------WEEEEERLRGLLRSR----------GAWEQQIKQ-LEAELSEF 347
++ L K+ L +E E+L+ L ++ G ++ Q ++ SEF
Sbjct: 2346 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2405
Query: 348 ----------RMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQA 397
+L+ ++ GL P+ KA ++ +++ + ++ V Q
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2464
Query: 398 QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
QL V +LK + Q + A +L + + + + W
Sbjct: 2465 QLDAFQVLVKSLKSWIKETTKKVPIVQP---------SFGAEDLGKSLEDTKKLQEKWSL 2515
Query: 458 LAQRLLEVT---ASLPDLPSLHTFLPQIEAALME----------SSRLKELLT---MLQL 501
+ +V SL +L S T + AA+ ++ +E + +
Sbjct: 2516 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
KKD+ G E LL+ + + + S + L + ++
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHK 621
V+ Q E+ + KQ ++++Q L+++ +L + P E P +
Sbjct: 2636 APTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEE----NPDTPEAPRWKQM 2690
Query: 622 MDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG--EAG 679
+ ++ S +Q L + D + +S F +L+QW+ V + + + G
Sbjct: 2691 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL-VEKELMVSVLGPLSID 2749
Query: 680 PGDAESQEAEFERLVAEFPEKEAQLSLVEA--QGWLVMEKSSPEGAAVVQEELRELAESW 737
P +Q + + L+ EF ++ Q + A QG L P +V+E+L + + W
Sbjct: 2750 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2809
Query: 738 RAL 740
+L
Sbjct: 2810 DSL 2812
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/578 (19%), Positives = 219/578 (37%), Gaps = 72/578 (12%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
V+ KA+ V L+ ++Q +FQ WL E+ +N PI+ +L L+
Sbjct: 2922 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEE------QNKSHPISAKLDVLE 2975
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE------ 317
+ KD ++L I L + E ++ L ++ W+
Sbjct: 2976 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 3035
Query: 318 -EEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRMVLQRLAQEGLQPAAK-AGTE 368
E E +L+ L +++Q++ L + L E + L EG AK +
Sbjct: 3036 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQ 3093
Query: 369 DELVAHW---RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQS 425
E+ H+ + T +L S ++ + +V N K L V ++ S
Sbjct: 3094 KEMDQHFGMVELLNNTANSLLS--------VCEIDKEVVTDEN-KSLIQKVDMVTEQLHS 3144
Query: 426 LKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K L N + ++ FQ ++ + A+ L++ SL + +L ++
Sbjct: 3145 ---KKFCLEN--MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199
Query: 486 LMESSRLKELLTML-QLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
LK + + +L +DL++ + + +L QV ++ L + ++ S L+
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3259
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
+ L F + + + + + + RD Q Q ++ ++ L A
Sbjct: 3260 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK---LEAL 3316
Query: 605 MEAARPLVQENPNHQHKM----DQLSSDFQALQRSLEDLVDRCR------QSVQEHCTFS 654
M + +N N KM ++ S D ++R LE L +C Q+ +E +
Sbjct: 3317 MAS-----NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3371
Query: 655 HQLLE-----LRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
+ LE L+++ ++ QK E H GP E++ + + + +KE L
Sbjct: 3372 IKRLEEFYSKLKEFSIL-LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3430
Query: 710 Q---GW----LVMEKSSPEGAAVVQEELRELAESWRAL 740
Q W L+ + ++ +L ++ W+ L
Sbjct: 3431 QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3468
Score = 42.7 bits (99), Expect = 0.002
Identities = 119/646 (18%), Positives = 254/646 (39%), Gaps = 73/646 (11%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +WM ++ + ++A++ E + + +L + + V+++ R
Sbjct: 3489 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3548
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
E + K IL +L + ++WE + + ++E + + + E L +E+
Sbjct: 3549 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3608
Query: 126 YRWFQKMMVTLEPHIELQLGLKEK--QWQLSHAQVLLHNVD-NQAVLLDRLLEEAASLFN 182
+K +V EP L+E+ Q + ++ HN +QAV + + L+ +S
Sbjct: 3609 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR-- 3666
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVV 240
D + + + Y ++ K+ R +LL+Q + + G DE +L WL V
Sbjct: 3667 --EDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIF--GEDEVELMNWLNEVH 3722
Query: 241 EKVN----------GCLGRNCKLPITQR--LSTLQDIAKDFPRGEESLETLEEQSAGVIR 288
+K++ G + +L + Q L Q++ + G E L+ +I+
Sbjct: 3723 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3782
Query: 289 NTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFR 348
+ E I +++ K+ + E+ + R L + + ++E EL +
Sbjct: 3783 DK----LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3838
Query: 349 MVL---QRLAQEGLQP---AAKAGTEDELVAHWRRYSATRAALASEEPR--VDRLQAQLK 400
+ + +Q ++P +A L+ S+ L R ++++ A+
Sbjct: 3839 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3898
Query: 401 ELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL-W-QHFQRPLQDLQLWKAL 458
E + +SD++ ++E + ++S + AA EL W ++ L +L
Sbjct: 3899 E------RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM------SL 3946
Query: 459 AQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
LE + L TF ME R K+++ L ++ +E ++
Sbjct: 3947 GDIRLEQDQTSAQLQVQKTF-------TMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3999
Query: 519 LEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ 578
+++ +++ D + +R +L+ + F +E L L + Q +
Sbjct: 4000 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ-------SII 4052
Query: 579 RDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQ 624
LP + L+ QEE L R L+ E+ H KM++
Sbjct: 4053 SQLPAPALEYETLRQQQEEHRQL-------RELIAEHKPHIDKMNK 4091
Score = 37.7 bits (86), Expect = 0.053
Identities = 85/431 (19%), Positives = 171/431 (39%), Gaps = 64/431 (14%)
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
L + ++ + G ++ L LK + ++N +LS LQ ++ +
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELN------------TKLSKLQKAQEESSAMMQ 2619
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRA---LWEEEEERLRGLLRSRG 331
L+ + + + + +P E + ++E+ + +L+ +E +++L LL
Sbjct: 2620 WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP 2679
Query: 332 ------AWEQQIKQLEA---ELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATR 382
W+Q + ++++ EL++ + Q+ +E + T + + W
Sbjct: 2680 DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW------- 2732
Query: 383 AALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW 442
L +E V + L L + P+ L V +QE+ + K + +L A L
Sbjct: 2733 --LVEKELMV----SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL- 2785
Query: 443 QHFQRPLQDLQLWKALAQRLLEVTASLPDLPS-LHTFLPQIEAALMESSRLKELLTMLQL 501
RP +D L + ++L VT L L I+ A+++S++ + LL L
Sbjct: 2786 ---SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS- 2841
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
D L + + ++ + +M N L+ K++ + Q K + Q
Sbjct: 2842 --DKLSDLDNKLSSSLAVSTHPDAM-------NQQLETAQKMKQEIQQEKK---QIKVAQ 2889
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNHQH 620
DL V+ E +A+LSR L+G+ + D+ + E +Q H
Sbjct: 2890 ALCEDLSALVKEEY--------LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2941
Query: 621 KMDQLSSDFQA 631
+ Q+S DFQA
Sbjct: 2942 QFQQMSRDFQA 2952
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 80.5 bits (197), Expect = 7e-15
Identities = 182/930 (19%), Positives = 384/930 (41%), Gaps = 117/930 (12%)
Query: 19 WMKAVQDQLQ---VND-NTQGPRAALEARLWETEKICQLEPEG----RVRVDLVLRMAEA 70
W+ V D+L V D +T+G LW+ + ++ E + VD L
Sbjct: 3539 WLNEVHDKLSKLSVQDYSTEG--------LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
LL GD+ I +L+ IKA++++ T +E +E W
Sbjct: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD 190
K+ V L + L +E + L N LLD L E +++L + P
Sbjct: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV--PWRA 3708
Query: 191 EDAQKRMKAE----YDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++M AE Y V ++V+ ++ +++ D W+ +K+
Sbjct: 3709 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS- 3767
Query: 247 LGRNCKLPITQRLSTLQDIAKDFP----RGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
LG + +L Q + LQ + K F R ++ ++ L + ++ S + + +L
Sbjct: 3768 LG-DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGA----WEQQIKQLEAELSEFRMVLQRLAQEG 358
+ KVL+ + + ER L R++ WE ++L L+E + ++ +L
Sbjct: 3826 D---KVLKNYDTICQINSERYLQLERAQSLVNQFWETY-EELWPWLTETQSIISQLPAPA 3881
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI-VFPHNLKPLSDSVI 417
L+ ++E + R +A +P +D++ +L+ + P + + +
Sbjct: 3882 LEYETLRQQQEE-------HRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3934
Query: 418 ATIQEYQSLKV---KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPS 474
A Y +K K A + A + Q + Q L+ + + +RL + + ++
Sbjct: 3935 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK 3994
Query: 475 LHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE----RATALLEQVAGSMRDRD 530
+ + + + ++ +L+ L L+ + + +I G A A+ +++ + +
Sbjct: 3995 IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE 4054
Query: 531 LLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ--VRVQAEKGLQRDLPGKQAQL 588
+H + +R++KL ++ + F L + D Q +R + G+ + +Q +
Sbjct: 4055 NIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEA 4114
Query: 589 SR-----LQGLQEE---GLDLGAQMEAA-----RPLVQENPNHQHKMDQLSSDFQALQRS 635
+ + GLQEE ++LG+++ AA +P+V+++ +D+L+S + +L ++
Sbjct: 4115 AETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS------IDELNSAWDSLNKA 4168
Query: 636 LEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG--DAESQEAEFERL 693
+D +D+ +++Q + L + W+ + KL A G + Q E ++
Sbjct: 4169 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL-ASMSPIGTDLETVKQQIEELKQF 4227
Query: 694 VAEFPEKEAQLSLVEAQGWLVMEKSSPEG-AAVVQEELRELAESWRAL--------RLLE 744
+E +++ ++ + Q L+++K + E VQ+ L EL W +L LE
Sbjct: 4228 KSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLE 4287
Query: 745 ESLLSLIRNWHL--QRMEVDSGKKMVFTNNIPKSGFLINPMDP--IPRHRRRANLLQEEE 800
+LL+L + H + + + + + + P G DP I + ++LQ +
Sbjct: 4288 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGG------DPKAIEIELAKHHVLQNDV 4341
Query: 801 GSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEAR-------VP 853
+H+ + + G L + +S E+ ++KL+ L R
Sbjct: 4342 LAHQSTVEAVNKAGNDL------------IESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
Query: 854 EGQHLFENLLRLGPARGTSDELEDLRYQWM 883
+ + + LR A+G E+EDL+ QW+
Sbjct: 4390 QRKQQLDGALR--QAKGFHGEIEDLQ-QWL 4416
Score = 60.8 bits (146), Expect = 6e-09
Identities = 138/639 (21%), Positives = 251/639 (39%), Gaps = 97/639 (15%)
Query: 136 LEPHIELQLGLKEK----QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD---PS 188
LE ++ Q+G ++ Q+Q AQ +QAV++ + A L + G P
Sbjct: 1745 LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVII--ATQSAQVLLEKQGQYLSPE 1802
Query: 189 VDEDAQKRMK---AEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
E QK MK Y+ A+++K++ L + E E++ A EF+ WL+
Sbjct: 1803 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQ-------- 1854
Query: 246 CLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
Q L L+ A D L+ + S VI + L I+G
Sbjct: 1855 --------QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISG----- 1901
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+VLE ++ +R G + + + ++L+ FR + + G
Sbjct: 1902 NRVLEAAKSC----SKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG------- 1950
Query: 366 GTEDELVAHWRRY-SATRAALASEEPRVDRLQAQLKE-LIVFPHNLKPLSDSVIATIQEY 423
+LV ++ Y A+ LA + L E + V P NL+ + A +
Sbjct: 1951 NNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQI 2010
Query: 424 QSLKVKSARLRNAAAVEL---------WQHFQRPLQDL-----QLWKALAQR----LLEV 465
S +V +L+ A V L Q+ L D+ L K++ +R + +
Sbjct: 2011 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2070
Query: 466 TASL---PDLPSLHTFLPQIEAALMESSRLKELLTMLQ--LKKDLLI--GIFG-QERATA 517
T SL L + ++ +E++L E ++ T LQ + K++++ I G Q A
Sbjct: 2071 TRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA 2130
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSK-----LQSLLAQHKDFGAAFEPLQRKL-------- 564
+ E+V M D S LQ K K +HK+ A E L+ K+
Sbjct: 2131 MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
Query: 565 -LDLQVRVQAEKGLQRDLPGKQ-AQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNH--- 618
L + + + + D+PGK +LS+ +Q E L+ +E L++E +H
Sbjct: 2191 KLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLP 2250
Query: 619 ------QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
K + LS F+ ++ ++++ + ++ F + L+ WI TT+K+
Sbjct: 2251 SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVP 2310
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQG 711
+ G D + ++L ++ K ++ V G
Sbjct: 2311 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 23/522 (4%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F +ED Q W+ + L + G + +L ++C +++
Sbjct: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ +LA CP + I + ++K +WE T + +++E E+ + +F W
Sbjct: 4465 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL--FNRIGD 186
+ TL L L +Q+ +V + V++ + L + L F++ D
Sbjct: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++ +++ ++ V + +R L+ + +++ + WL+ + ++
Sbjct: 4585 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4644
Query: 247 LG-RNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE-KITGELEE 304
L N I +L+ ++ K +T + TS K+ L E
Sbjct: 4645 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4704
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+R + + E + +L L G Q L+A + V +LA++ QP
Sbjct: 4705 LRDKWDTICGKSVERQNKLEEALLFSG---QFTDALQALIDWLYRVEPQLAED--QPV-- 4757
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
G D ++ + A + L V L+ +ELI + S V +QE
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQMQELS 4814
Query: 425 -------SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLH 476
+L + S + R AA+ + F + L W A A++ L LP D +L
Sbjct: 4815 TRWETVCALSI-SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4873
Query: 477 TFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
T + Q + + + + L D ++ I + T +
Sbjct: 4874 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915
Score = 46.6 bits (109), Expect = 1e-04
Identities = 120/663 (18%), Positives = 243/663 (36%), Gaps = 91/663 (13%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMK---AEYD 202
K Q QL + L + +Q V +++L + A L + G D QK + Y+
Sbjct: 1994 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 2053
Query: 203 AVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTL 262
+ +R + L+ Q G+DE W+ V L ++P+ + L
Sbjct: 2054 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG----NVESSLKEQGQVPLNS--TAL 2107
Query: 263 QDIA-------KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM---------- 305
QDI +D + S+ + E+ + T P A + +++++
Sbjct: 2108 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2167
Query: 306 -RKVLEKLRAL------WEEEEERLRGLLRSR----------GAWEQQIKQ-LEAELSEF 347
++ L K+ L +E E+L+ L ++ G ++ Q ++ SEF
Sbjct: 2168 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2227
Query: 348 ----------RMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQA 397
+L+ ++ GL P+ KA ++ +++ + ++ V Q
Sbjct: 2228 LEHKKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2286
Query: 398 QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
QL V +LK + Q + A +L + + + + W
Sbjct: 2287 QLDAFQVLVKSLKSWIKETTKKVPIVQP---------SFGAEDLGKSLEDTKKLQEKWSL 2337
Query: 458 LAQRLLEVT---ASLPDLPSLHTFLPQIEAALME----------SSRLKELLT---MLQL 501
+ +V SL +L S T + AA+ ++ +E + +
Sbjct: 2338 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
KKD+ G E LL+ + + + S + L + ++
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHK 621
V+ Q E+ + KQ ++++Q L+++ +L + P E P +
Sbjct: 2458 APTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEE----NPDTPEAPRWKQM 2512
Query: 622 MDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG--EAG 679
+ ++ S +Q L + D + +S F +L+QW+ V + + + G
Sbjct: 2513 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL-VEKELMVSVLGPLSID 2571
Query: 680 PGDAESQEAEFERLVAEFPEKEAQLSLVEA--QGWLVMEKSSPEGAAVVQEELRELAESW 737
P +Q + + L+ EF ++ Q + A QG L P +V+E+L + + W
Sbjct: 2572 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2631
Query: 738 RAL 740
+L
Sbjct: 2632 DSL 2634
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/578 (19%), Positives = 219/578 (37%), Gaps = 72/578 (12%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
V+ KA+ V L+ ++Q +FQ WL E+ +N PI+ +L L+
Sbjct: 2744 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEE------QNKSHPISAKLDVLE 2797
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE------ 317
+ KD ++L I L + E ++ L ++ W+
Sbjct: 2798 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2857
Query: 318 -EEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRMVLQRLAQEGLQPAAK-AGTE 368
E E +L+ L +++Q++ L + L E + L EG AK +
Sbjct: 2858 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQ 2915
Query: 369 DELVAHW---RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQS 425
E+ H+ + T +L S ++ + +V N K L V ++ S
Sbjct: 2916 KEMDQHFGMVELLNNTANSLLS--------VCEIDKEVVTDEN-KSLIQKVDMVTEQLHS 2966
Query: 426 LKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K L N + ++ FQ ++ + A+ L++ SL + +L ++
Sbjct: 2967 ---KKFCLEN--MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3021
Query: 486 LMESSRLKELLTML-QLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
LK + + +L +DL++ + + +L QV ++ L + ++ S L+
Sbjct: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3081
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
+ L F + + + + + + RD Q Q ++ ++ L A
Sbjct: 3082 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK---LEAL 3138
Query: 605 MEAARPLVQENPNHQHKM----DQLSSDFQALQRSLEDLVDRCR------QSVQEHCTFS 654
M + +N N KM ++ S D ++R LE L +C Q+ +E +
Sbjct: 3139 MAS-----NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 3193
Query: 655 HQLLE-----LRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
+ LE L+++ ++ QK E H GP E++ + + + +KE L
Sbjct: 3194 IKRLEEFYSKLKEFSIL-LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3252
Query: 710 Q---GW----LVMEKSSPEGAAVVQEELRELAESWRAL 740
Q W L+ + ++ +L ++ W+ L
Sbjct: 3253 QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3290
Score = 42.7 bits (99), Expect = 0.002
Identities = 119/646 (18%), Positives = 254/646 (39%), Gaps = 73/646 (11%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +WM ++ + ++A++ E + + +L + + V+++ R
Sbjct: 3311 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3370
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
E + K IL +L + ++WE + + ++E + + + E L +E+
Sbjct: 3371 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3430
Query: 126 YRWFQKMMVTLEPHIELQLGLKEK--QWQLSHAQVLLHNVD-NQAVLLDRLLEEAASLFN 182
+K +V EP L+E+ Q + ++ HN +QAV + + L+ +S
Sbjct: 3431 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR-- 3488
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVV 240
D + + + Y ++ K+ R +LL+Q + + G DE +L WL V
Sbjct: 3489 --EDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIF--GEDEVELMNWLNEVH 3544
Query: 241 EKVN----------GCLGRNCKLPITQR--LSTLQDIAKDFPRGEESLETLEEQSAGVIR 288
+K++ G + +L + Q L Q++ + G E L+ +I+
Sbjct: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604
Query: 289 NTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFR 348
+ E I +++ K+ + E+ + R L + + ++E EL +
Sbjct: 3605 DK----LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660
Query: 349 MVL---QRLAQEGLQP---AAKAGTEDELVAHWRRYSATRAALASEEPR--VDRLQAQLK 400
+ + +Q ++P +A L+ S+ L R ++++ A+
Sbjct: 3661 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3720
Query: 401 ELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL-W-QHFQRPLQDLQLWKAL 458
E + +SD++ ++E + ++S + AA EL W ++ L +L
Sbjct: 3721 E------RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM------SL 3768
Query: 459 AQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
LE + L TF ME R K+++ L ++ +E ++
Sbjct: 3769 GDIRLEQDQTSAQLQVQKTF-------TMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3821
Query: 519 LEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ 578
+++ +++ D + +R +L+ + F +E L L + Q +
Sbjct: 3822 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ-------SII 3874
Query: 579 RDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQ 624
LP + L+ QEE L R L+ E+ H KM++
Sbjct: 3875 SQLPAPALEYETLRQQQEEHRQL-------RELIAEHKPHIDKMNK 3913
Score = 37.7 bits (86), Expect = 0.053
Identities = 85/431 (19%), Positives = 171/431 (39%), Gaps = 64/431 (14%)
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
L + ++ + G ++ L LK + ++N +LS LQ ++ +
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELN------------TKLSKLQKAQEESSAMMQ 2441
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRA---LWEEEEERLRGLLRSRG 331
L+ + + + + +P E + ++E+ + +L+ +E +++L LL
Sbjct: 2442 WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP 2501
Query: 332 ------AWEQQIKQLEA---ELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATR 382
W+Q + ++++ EL++ + Q+ +E + T + + W
Sbjct: 2502 DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW------- 2554
Query: 383 AALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW 442
L +E V + L L + P+ L V +QE+ + K + +L A L
Sbjct: 2555 --LVEKELMV----SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL- 2607
Query: 443 QHFQRPLQDLQLWKALAQRLLEVTASLPDLPS-LHTFLPQIEAALMESSRLKELLTMLQL 501
RP +D L + ++L VT L L I+ A+++S++ + LL L
Sbjct: 2608 ---SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS- 2663
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
D L + + ++ + +M N L+ K++ + Q K + Q
Sbjct: 2664 --DKLSDLDNKLSSSLAVSTHPDAM-------NQQLETAQKMKQEIQQEKK---QIKVAQ 2711
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNHQH 620
DL V+ E +A+LSR L+G+ + D+ + E +Q H
Sbjct: 2712 ALCEDLSALVKEEY--------LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2763
Query: 621 KMDQLSSDFQA 631
+ Q+S DFQA
Sbjct: 2764 QFQQMSRDFQA 2774
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 80.5 bits (197), Expect = 7e-15
Identities = 182/930 (19%), Positives = 384/930 (41%), Gaps = 117/930 (12%)
Query: 19 WMKAVQDQLQ---VND-NTQGPRAALEARLWETEKICQLEPEG----RVRVDLVLRMAEA 70
W+ V D+L V D +T+G LW+ + ++ E + VD L
Sbjct: 3213 WLNEVHDKLSKLSVQDYSTEG--------LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3264
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
LL GD+ I +L+ IKA++++ T +E +E W
Sbjct: 3265 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3324
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD 190
K+ V L + L +E + L N LLD L E +++L + P
Sbjct: 3325 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELV--PWRA 3382
Query: 191 EDAQKRMKAE----YDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++M AE Y V ++V+ ++ +++ D W+ +K+
Sbjct: 3383 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMS- 3441
Query: 247 LGRNCKLPITQRLSTLQDIAKDFP----RGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
LG + +L Q + LQ + K F R ++ ++ L + ++ S + + +L
Sbjct: 3442 LG-DIRLEQDQTSAQLQ-VQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3499
Query: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGA----WEQQIKQLEAELSEFRMVLQRLAQEG 358
+ KVL+ + + ER L R++ WE ++L L+E + ++ +L
Sbjct: 3500 D---KVLKNYDTICQINSERYLQLERAQSLVNQFWETY-EELWPWLTETQSIISQLPAPA 3555
Query: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI-VFPHNLKPLSDSVI 417
L+ ++E + R +A +P +D++ +L+ + P + + +
Sbjct: 3556 LEYETLRQQQEE-------HRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3608
Query: 418 ATIQEYQSLKV---KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPS 474
A Y +K K A + A + Q + Q L+ + + +RL + + ++
Sbjct: 3609 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK 3668
Query: 475 LHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE----RATALLEQVAGSMRDRD 530
+ + + + ++ +L+ L L+ + + +I G A A+ +++ + +
Sbjct: 3669 IKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE 3728
Query: 531 LLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ--VRVQAEKGLQRDLPGKQAQL 588
+H + +R++KL ++ + F L + D Q +R + G+ + +Q +
Sbjct: 3729 NIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEA 3788
Query: 589 SR-----LQGLQEE---GLDLGAQMEAA-----RPLVQENPNHQHKMDQLSSDFQALQRS 635
+ + GLQEE ++LG+++ AA +P+V+++ +D+L+S + +L ++
Sbjct: 3789 AETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS------IDELNSAWDSLNKA 3842
Query: 636 LEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG--DAESQEAEFERL 693
+D +D+ +++Q + L + W+ + KL A G + Q E ++
Sbjct: 3843 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL-ASMSPIGTDLETVKQQIEELKQF 3901
Query: 694 VAEFPEKEAQLSLVEAQGWLVMEKSSPEG-AAVVQEELRELAESWRAL--------RLLE 744
+E +++ ++ + Q L+++K + E VQ+ L EL W +L LE
Sbjct: 3902 KSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLE 3961
Query: 745 ESLLSLIRNWHL--QRMEVDSGKKMVFTNNIPKSGFLINPMDP--IPRHRRRANLLQEEE 800
+LL+L + H + + + + + + P G DP I + ++LQ +
Sbjct: 3962 GALLALGQFQHALDELLAWLTHTEGLLSEQKPVGG------DPKAIEIELAKHHVLQNDV 4015
Query: 801 GSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEAR-------VP 853
+H+ + + G L + +S E+ ++KL+ L R
Sbjct: 4016 LAHQSTVEAVNKAGNDL------------IESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4063
Query: 854 EGQHLFENLLRLGPARGTSDELEDLRYQWM 883
+ + + LR A+G E+EDL+ QW+
Sbjct: 4064 QRKQQLDGALR--QAKGFHGEIEDLQ-QWL 4090
Score = 60.8 bits (146), Expect = 6e-09
Identities = 138/639 (21%), Positives = 251/639 (39%), Gaps = 97/639 (15%)
Query: 136 LEPHIELQLGLKEK----QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD---PS 188
LE ++ Q+G ++ Q+Q AQ +QAV++ + A L + G P
Sbjct: 1419 LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVII--ATQSAQVLLEKQGQYLSPE 1476
Query: 189 VDEDAQKRMK---AEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
E QK MK Y+ A+++K++ L + E E++ A EF+ WL+
Sbjct: 1477 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQ-------- 1528
Query: 246 CLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
Q L L+ A D L+ + S VI + L I+G
Sbjct: 1529 --------QSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISG----- 1575
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+VLE ++ +R G + + + ++L+ FR + + G
Sbjct: 1576 NRVLEAAKSC----SKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLG------- 1624
Query: 366 GTEDELVAHWRRY-SATRAALASEEPRVDRLQAQLKE-LIVFPHNLKPLSDSVIATIQEY 423
+LV ++ Y A+ LA + L E + V P NL+ + A +
Sbjct: 1625 NNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQI 1684
Query: 424 QSLKVKSARLRNAAAVEL---------WQHFQRPLQDL-----QLWKALAQR----LLEV 465
S +V +L+ A V L Q+ L D+ L K++ +R + +
Sbjct: 1685 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 1744
Query: 466 TASL---PDLPSLHTFLPQIEAALMESSRLKELLTMLQ--LKKDLLI--GIFG-QERATA 517
T SL L + ++ +E++L E ++ T LQ + K++++ I G Q A
Sbjct: 1745 TRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA 1804
Query: 518 LLEQVAGSMRDRDLLHNSLLQRKSK-----LQSLLAQHKDFGAAFEPLQRKL-------- 564
+ E+V M D S LQ K K +HK+ A E L+ K+
Sbjct: 1805 MNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 1864
Query: 565 -LDLQVRVQAEKGLQRDLPGKQ-AQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNH--- 618
L + + + + D+PGK +LS+ +Q E L+ +E L++E +H
Sbjct: 1865 KLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLP 1924
Query: 619 ------QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
K + LS F+ ++ ++++ + ++ F + L+ WI TT+K+
Sbjct: 1925 SDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVP 1984
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQG 711
+ G D + ++L ++ K ++ V G
Sbjct: 1985 IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2023
Score = 48.9 bits (115), Expect = 2e-05
Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 23/522 (4%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F +ED Q W+ + L + G + +L ++C +++
Sbjct: 4079 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4138
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ +LA CP + I + ++K +WE T + +++E E+ + +F W
Sbjct: 4139 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4198
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL--FNRIGD 186
+ TL L L +Q+ +V + V++ + L + L F++ D
Sbjct: 4199 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4258
Query: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC 246
+ ++ +++ ++ V + +R L+ + +++ + WL+ + ++
Sbjct: 4259 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4318
Query: 247 LG-RNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE-KITGELEE 304
L N I +L+ ++ K +T + TS K+ L E
Sbjct: 4319 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4378
Query: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
+R + + E + +L L G Q L+A + V +LA++ QP
Sbjct: 4379 LRDKWDTICGKSVERQNKLEEALLFSG---QFTDALQALIDWLYRVEPQLAED--QPV-- 4431
Query: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
G D ++ + A + L V L+ +ELI + S V +QE
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQMQELS 4488
Query: 425 -------SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLH 476
+L + S + R AA+ + F + L W A A++ L LP D +L
Sbjct: 4489 TRWETVCALSI-SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALR 4547
Query: 477 TFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
T + Q + + + + L D ++ I + T +
Sbjct: 4548 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589
Score = 46.6 bits (109), Expect = 1e-04
Identities = 120/663 (18%), Positives = 243/663 (36%), Gaps = 91/663 (13%)
Query: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMK---AEYD 202
K Q QL + L + +Q V +++L + A L + G D QK + Y+
Sbjct: 1668 KNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYE 1727
Query: 203 AVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTL 262
+ +R + L+ Q G+DE W+ V L ++P+ + L
Sbjct: 1728 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMG----NVESSLKEQGQVPLNS--TAL 1781
Query: 263 QDIA-------KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM---------- 305
QDI +D + S+ + E+ + T P A + +++++
Sbjct: 1782 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 1841
Query: 306 -RKVLEKLRAL------WEEEEERLRGLLRSR----------GAWEQQIKQ-LEAELSEF 347
++ L K+ L +E E+L+ L ++ G ++ Q ++ SEF
Sbjct: 1842 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 1901
Query: 348 ----------RMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQA 397
+L+ ++ GL P+ KA ++ +++ + ++ V Q
Sbjct: 1902 LEHKKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 1960
Query: 398 QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
QL V +LK + Q + A +L + + + + W
Sbjct: 1961 QLDAFQVLVKSLKSWIKETTKKVPIVQP---------SFGAEDLGKSLEDTKKLQEKWSL 2011
Query: 458 LAQRLLEVT---ASLPDLPSLHTFLPQIEAALME----------SSRLKELLT---MLQL 501
+ +V SL +L S T + AA+ ++ +E + +
Sbjct: 2012 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
KKD+ G E LL+ + + + S + L + ++
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHK 621
V+ Q E+ + KQ ++++Q L+++ +L + P E P +
Sbjct: 2132 APTDTEAVKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEE----NPDTPEAPRWKQM 2186
Query: 622 MDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG--EAG 679
+ ++ S +Q L + D + +S F +L+QW+ V + + + G
Sbjct: 2187 LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL-VEKELMVSVLGPLSID 2245
Query: 680 PGDAESQEAEFERLVAEFPEKEAQLSLVEA--QGWLVMEKSSPEGAAVVQEELRELAESW 737
P +Q + + L+ EF ++ Q + A QG L P +V+E+L + + W
Sbjct: 2246 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2305
Query: 738 RAL 740
+L
Sbjct: 2306 DSL 2308
Score = 45.4 bits (106), Expect = 3e-04
Identities = 110/578 (19%), Positives = 219/578 (37%), Gaps = 72/578 (12%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
V+ KA+ V L+ ++Q +FQ WL E+ +N PI+ +L L+
Sbjct: 2418 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEE------QNKSHPISAKLDVLE 2471
Query: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE------ 317
+ KD ++L I L + E ++ L ++ W+
Sbjct: 2472 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2531
Query: 318 -EEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRMVLQRLAQEGLQPAAK-AGTE 368
E E +L+ L +++Q++ L + L E + L EG AK +
Sbjct: 2532 KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLKSLQ 2589
Query: 369 DELVAHW---RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQS 425
E+ H+ + T +L S ++ + +V N K L V ++ S
Sbjct: 2590 KEMDQHFGMVELLNNTANSLLS--------VCEIDKEVVTDEN-KSLIQKVDMVTEQLHS 2640
Query: 426 LKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K L N + ++ FQ ++ + A+ L++ SL + +L ++
Sbjct: 2641 ---KKFCLEN--MTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695
Query: 486 LMESSRLKELLTML-QLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
LK + + +L +DL++ + + +L QV ++ L + ++ S L+
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 2755
Query: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
+ L F + + + + + + RD Q Q ++ ++ L A
Sbjct: 2756 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK---LEAL 2812
Query: 605 MEAARPLVQENPNHQHKM----DQLSSDFQALQRSLEDLVDRCR------QSVQEHCTFS 654
M + +N N KM ++ S D ++R LE L +C Q+ +E +
Sbjct: 2813 MAS-----NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT 2867
Query: 655 HQLLE-----LRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
+ LE L+++ ++ QK E H GP E++ + + + +KE L
Sbjct: 2868 IKRLEEFYSKLKEFSIL-LQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 2926
Query: 710 Q---GW----LVMEKSSPEGAAVVQEELRELAESWRAL 740
Q W L+ + ++ +L ++ W+ L
Sbjct: 2927 QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 2964
Score = 42.7 bits (99), Expect = 0.002
Identities = 119/646 (18%), Positives = 254/646 (39%), Gaps = 73/646 (11%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +WM ++ + ++A++ E + + +L + + V+++ R
Sbjct: 2985 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3044
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
E + K IL +L + ++WE + + ++E + + + E L +E+
Sbjct: 3045 EKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEW 3104
Query: 126 YRWFQKMMVTLEPHIELQLGLKEK--QWQLSHAQVLLHNVD-NQAVLLDRLLEEAASLFN 182
+K +V EP L+E+ Q + ++ HN +QAV + + L+ +S
Sbjct: 3105 LTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR-- 3162
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVV 240
D + + + Y ++ K+ R +LL+Q + + G DE +L WL V
Sbjct: 3163 --EDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIF--GEDEVELMNWLNEVH 3218
Query: 241 EKVN----------GCLGRNCKLPITQR--LSTLQDIAKDFPRGEESLETLEEQSAGVIR 288
+K++ G + +L + Q L Q++ + G E L+ +I+
Sbjct: 3219 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3278
Query: 289 NTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFR 348
+ E I +++ K+ + E+ + R L + + ++E EL +
Sbjct: 3279 DK----LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3334
Query: 349 MVL---QRLAQEGLQP---AAKAGTEDELVAHWRRYSATRAALASEEPR--VDRLQAQLK 400
+ + +Q ++P +A L+ S+ L R ++++ A+
Sbjct: 3335 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3394
Query: 401 ELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL-W-QHFQRPLQDLQLWKAL 458
E + +SD++ ++E + ++S + AA EL W ++ L +L
Sbjct: 3395 E------RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM------SL 3442
Query: 459 AQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL 518
LE + L TF ME R K+++ L ++ +E ++
Sbjct: 3443 GDIRLEQDQTSAQLQVQKTF-------TMEILRHKDIIDDLVKSGHKIMTACSEEEKQSM 3495
Query: 519 LEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ 578
+++ +++ D + +R +L+ + F +E L L + Q +
Sbjct: 3496 KKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ-------SII 3548
Query: 579 RDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQ 624
LP + L+ QEE L R L+ E+ H KM++
Sbjct: 3549 SQLPAPALEYETLRQQQEEHRQL-------RELIAEHKPHIDKMNK 3587
Score = 37.7 bits (86), Expect = 0.053
Identities = 85/431 (19%), Positives = 171/431 (39%), Gaps = 64/431 (14%)
Query: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
L + ++ + G ++ L LK + ++N +LS LQ ++ +
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELN------------TKLSKLQKAQEESSAMMQ 2115
Query: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRA---LWEEEEERLRGLLRSRG 331
L+ + + + + +P E + ++E+ + +L+ +E +++L LL
Sbjct: 2116 WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP 2175
Query: 332 ------AWEQQIKQLEA---ELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATR 382
W+Q + ++++ EL++ + Q+ +E + T + + W
Sbjct: 2176 DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW------- 2228
Query: 383 AALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW 442
L +E V + L L + P+ L V +QE+ + K + +L A L
Sbjct: 2229 --LVEKELMV----SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL- 2281
Query: 443 QHFQRPLQDLQLWKALAQRLLEVTASLPDLPS-LHTFLPQIEAALMESSRLKELLTMLQL 501
RP +D L + ++L VT L L I+ A+++S++ + LL L
Sbjct: 2282 ---SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLS- 2337
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQ 561
D L + + ++ + +M N L+ K++ + Q K + Q
Sbjct: 2338 --DKLSDLDNKLSSSLAVSTHPDAM-------NQQLETAQKMKQEIQQEKK---QIKVAQ 2385
Query: 562 RKLLDLQVRVQAEKGLQRDLPGKQAQLSR-LQGLQEEGLDLGAQMEAARPLVQENPNHQH 620
DL V+ E +A+LSR L+G+ + D+ + E +Q H
Sbjct: 2386 ALCEDLSALVKEEY--------LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSH 2437
Query: 621 KMDQLSSDFQA 631
+ Q+S DFQA
Sbjct: 2438 QFQQMSRDFQA 2448
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform
2 [Homo sapiens]
Length = 429
Score = 77.0 bits (188), Expect = 8e-14
Identities = 95/359 (26%), Positives = 147/359 (40%), Gaps = 33/359 (9%)
Query: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 79 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 135
Query: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQ- 757
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 136 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 194
Query: 758 -------RMEVDSGKK-----------MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQE 798
R +V K + N + + +P DP R L+Q
Sbjct: 195 QGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 254
Query: 799 EEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQH 857
E+ E Q+ ++ NS L++ AE+ + + KL++L +V +
Sbjct: 255 EKELVERQPQV----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLM 310
Query: 858 LFENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRGLG 917
+ + DE++ + + + E T + R
Sbjct: 311 ALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETESRVPGSTRPQR 370
Query: 918 SLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPPT 975
S R ALPLQLLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPPT
Sbjct: 371 SFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT 429
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform
4 [Homo sapiens]
Length = 556
Score = 76.6 bits (187), Expect = 1e-13
Identities = 98/361 (27%), Positives = 150/361 (41%), Gaps = 36/361 (9%)
Query: 642 RCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERL---VAEFP 698
+ +Q++Q+ + + + W+ T +LE + P D + E +RL + F
Sbjct: 205 KIKQNLQQ---LNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFD 261
Query: 699 EKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQ- 757
+A + V ++ SPE + Q LR+L+ W A + +S +R +Q
Sbjct: 262 TYKALVVSVNVSSKEFLQTESPESTEL-QSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQC 320
Query: 758 -------RMEVDSGKK-----------MVFTNNIPKSGFLINPM-DPIPRHRRRANLLQE 798
R +V K + N + + +P DP R L+Q
Sbjct: 321 QGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQL 380
Query: 799 EEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED-LRTRKSKLQELEARVPEGQH 857
E+ E Q+ ++ NS L++ AE+ + + KL++L +V +
Sbjct: 381 EKELVERQPQV----DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLM 436
Query: 858 LFENLLRLGPARGTSDELE--DLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQKTRRWRG 915
+ + DE++ D + + K + T E T + R
Sbjct: 437 ALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRAKQFRAVRTTEGE-EETESRVPGSTRP 495
Query: 916 LGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSCTLANNFARSFTLMLRY-NGPPP 974
S R ALPLQLLLLL LLL LLP EED SCT ANNFARSF MLRY NGPPP
Sbjct: 496 QRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 555
Query: 975 T 975
T
Sbjct: 556 T 556
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 74.7 bits (182), Expect = 4e-13
Identities = 136/697 (19%), Positives = 277/697 (39%), Gaps = 47/697 (6%)
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
L+ C +KP + + ++ WE ++E +Y + W
Sbjct: 4615 LIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD 4674
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPS-- 188
++ L + L + QL+ + V Q + +++L + + + D +
Sbjct: 4675 NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDR 4734
Query: 189 -VDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC- 246
+ + +K ++ + K R LE ++Q ++E WL E ++
Sbjct: 4735 DIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQR 4794
Query: 247 -LGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
+ + K+ I L+ + D + ++ET+ + ++ +++ A + LE M
Sbjct: 4795 PISGDPKV-IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4853
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+ E + EE E++L+ L+ + +I+ EL+ L G P
Sbjct: 4854 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET-- 4911
Query: 366 GTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ- 424
++L H YS +A + +D+ + L K SV Q++
Sbjct: 4912 -AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKT-EQSVALLEQKWHV 4969
Query: 425 -SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
S K++ + + A+ L FQ LQ+ W LA++ L + AS P L L+T L QIE
Sbjct: 4970 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI-ASPPSL-ILNTVLSQIE 5027
Query: 484 AALMESSRLK----ELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDR-DLLHNSLLQ 538
+ ++ + +++ + Q L Q++ L++ + S++ R + + ++
Sbjct: 5028 EHKVFANEVNAHRDQIIELDQTGNQL--KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 5085
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG 598
R L + K F A++ L L D + + +E + D + QLS+ + Q+
Sbjct: 5086 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK-- 5143
Query: 599 LDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR----CRQSV------Q 648
LG + ++ + K L D Q L L ++ D+ C +SV +
Sbjct: 5144 -TLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 5201
Query: 649 EHCTFSHQLLELRQWIVVTTQKLEAHRGEAGP--GDAE------SQEAEFERLVAEFPEK 700
E FS Q ++ Q +V K+E E P GD + F++ E ++
Sbjct: 5202 EALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQK---ELGKR 5258
Query: 701 EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESW 737
+ +++ G ++E +S + V+ +L+EL+ W
Sbjct: 5259 TGTVQVLKRSGRELIE-NSRDDTTWVKGQLQELSTRW 5294
Score = 70.9 bits (172), Expect = 6e-12
Identities = 201/1036 (19%), Positives = 373/1036 (36%), Gaps = 183/1036 (17%)
Query: 2 TQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRV 61
TQQ Q FD + + W+ Q Q N L+++L E E+ + +
Sbjct: 3235 TQQFQQMFD----ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
Query: 62 DLVLRMAEALLACCP-GDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLL 120
++++ E+LL P G++K + +L ++K WEE SR++ +Y
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
Query: 121 ARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL 180
++ W + + + + L + + L ++ +L+ V+ + LL+ +L AA +
Sbjct: 3351 HVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLE-ILNSAADI 3408
Query: 181 FNRIGDPSVDEDAQKRMKA----EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWL 236
I DED + KA DAV + Q + LE++ + E+Q + +
Sbjct: 3409 L--INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 3466
Query: 237 KAVVEKV--------NGCLGRN-----CKLPITQRLSTLQDIAKDFPRG----------- 272
+ ++ C +N + + Q L D ++F +G
Sbjct: 3467 EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3526
Query: 273 -----------EESLETLEEQSAGVIRNTSPL---------------------------- 293
+E LE + ++G + + L
Sbjct: 3527 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMG 3586
Query: 294 ----GAEKITGELEEMRKVLEKLRA---------------LWEEEEERLRGLLRSRGAWE 334
+ + ++E++R L K+ L EE L GL R A
Sbjct: 3587 AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3646
Query: 335 QQIKQL----EAELSEFRMVLQRLAQ-----EGLQPAAKAGTEDELVAHW---RRYSATR 382
+Q +L +A + + L R+ +GL A A E E + W
Sbjct: 3647 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL-QWVVGTEVEIIN 3705
Query: 383 AALAS----EEPRVDRLQAQLKELIVFPHNL----------KPLSDSVIATIQEYQSLKV 428
LA ++ +VD LQ +L+++ L + L + + +L
Sbjct: 3706 QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3765
Query: 429 KSARLRNAAAVELWQH---FQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K A+ R A E H FQ L+ L W A + L+ + PS ++A
Sbjct: 3766 KVAQ-RIAQLQEALLHCGKFQDALEPLLSWLADTEELI----ANQKPPSAE--YKVVKAQ 3818
Query: 486 LMESSRLKELLTMLQLKKDLLI---GIFGQERATALLEQVAGSMRDRDLLHNSLLQ---- 538
+ E L+ LL + D+L G Q A E++ G + + LL
Sbjct: 3819 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3878
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG 598
R+ +L+ +L K F EP+ L + ++ + + Q Q+ R + L+E+
Sbjct: 3879 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3938
Query: 599 LDLGAQMEAARPLVQENPNHQHKMDQ--LSSDFQALQRSLEDLVDRC-------RQSVQE 649
+ + A + Q + +Q LS +LQ ++ DRC Q++
Sbjct: 3939 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3998
Query: 650 HCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVE 708
F +E+ W+ KL + + D Q A+ L E ++ +
Sbjct: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
Query: 709 AQGWLVMEKSSPEGAAVVQEELREL--------AESWRALRLLEESLLSLIRNWHLQRME 760
G ++++++ E ++QE+L + S +ALR LE++ L + E
Sbjct: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA-RQLATKFQSTYEE 4117
Query: 761 VDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSH-------EDFSQLLRNF 813
+ + V + SG + IP+ ++R L++E H + S+ L
Sbjct: 4118 LTGWLREV-EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL 4176
Query: 814 GQWLQVEN-SKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFE------------ 860
W E KLV + D T ++ E++A + Q +
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSD--TIGQRVDEIDAAIQRSQQYEQAADAELAWVAET 4234
Query: 861 --NLLRLGPARGTSDE 874
L+ LGP R D+
Sbjct: 4235 KRKLMALGPIRLEQDQ 4250
Score = 69.7 bits (169), Expect = 1e-11
Identities = 161/854 (18%), Positives = 326/854 (38%), Gaps = 119/854 (13%)
Query: 86 RLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLG 145
+LKD ++ + T S + + + ++ + D W Q +E + +
Sbjct: 2407 KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVA 2466
Query: 146 LKEK--QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD----EDAQKRMKA 199
Q QL+ + L + V +++L + A + G+P+ D ++ + +
Sbjct: 2467 SDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILS 2526
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQR- 258
+ ++ +R LL++ + + Q ++ + V + + G + + Q
Sbjct: 2527 HFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA 2586
Query: 259 LSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEE 318
L+T + +D R + SLE E + A + G+L E+ + E+L +E
Sbjct: 2587 LATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQE 2646
Query: 319 EEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRY 378
+E L+ LL + + L +L +F R+ G QP + ++ +++
Sbjct: 2647 KESSLKKLLPQ----AEMFEHLSGKLQQFMENKSRMLASGNQP------DQDITHFFQQI 2696
Query: 379 SATRAALASEEPRVDRLQAQLKEL--IVFPHNLKPLSDSVIATIQEYQSLK--VKSARLR 434
+ ++ +D L+ + EL F +L D V +++ L+ VK
Sbjct: 2697 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD 2756
Query: 435 NAAAVELWQHFQRPLQDLQLW-----------------KALAQRLLEVTASLPDLPSLHT 477
++ E F++ ++ Q W K L +++ + + L D S T
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2816
Query: 478 FLPQI--EAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL-------LEQVAGSMRD 528
+ +I + +E+ ++ Q K ++ G + L ++ M D
Sbjct: 2817 LVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2876
Query: 529 RDL----LHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQRD 580
+L L L +R+ LQ++L + HK+ + + L+ K L+ + +
Sbjct: 2877 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2936
Query: 581 LPGKQAQLSR--LQGLQEEGLDLGAQMEAARPLVQENPNHQHK------MDQLSSDFQAL 632
QA+ ++ L L++ + EA L+ PN Q ++L+S +
Sbjct: 2937 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW--- 2993
Query: 633 QRSLEDLVDRCRQ---SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAE----- 684
+R+ E V R RQ S F +LR W++ + E G GP +
Sbjct: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLM----EKELMMGVLGPLSIDPNMLN 3049
Query: 685 SQEAEFERLVAEFPEKEAQLSLVE--AQGWLVMEKSSPEGAAVVQEELRELAESWRALRL 742
+Q+ + + ++ EF + Q + AQG L + VQ+EL+ + + W
Sbjct: 3050 AQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKW----- 3104
Query: 743 LEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS 802
+ L + + ++D I + + LLQ
Sbjct: 3105 -----VELTDKLNSRSSQIDQA---------------------IVKSTQYQELLQ----- 3133
Query: 803 HEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENL 862
D S+ +R GQ L V+++ + A++ E R S L++L+ V E Q L + L
Sbjct: 3134 --DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR-SDLEQLDHEVKEAQTLCDEL 3190
Query: 863 LRLGPARGTSDELE 876
L + DEL+
Sbjct: 3191 SVLIGEQYLKDELK 3204
Score = 54.7 bits (130), Expect = 4e-07
Identities = 134/766 (17%), Positives = 295/766 (38%), Gaps = 50/766 (6%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEP-EGRVRVDLVLRM 67
F + E+ W++ V+++L + Q P + + +K + E E R+ +D V +
Sbjct: 4111 FQSTYEELTGWLREVEEELATSGG-QSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169
Query: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
+ ALL P + G+ + D Q++ + I+ +Y A D
Sbjct: 4170 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 4229
Query: 128 WF----QKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
W +K+M +E + Q Q + + ++ + D+ +D L + +F
Sbjct: 4230 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDS----MDELFSHRSEIFGT 4285
Query: 184 IGDP--SVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKA--- 238
G+ +V ++ + + +Y+A+ +R LE+ ++ +E W++
Sbjct: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
Query: 239 -VVEKVNGCLGRNCKLPITQRLSTLQD-IAKDFPRGEESLETLEEQSAGVIRNTSPLGAE 296
+ + + + + + L++ IA+ P ++ L+ + ++ +P E
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-----LKELNPEEGE 4400
Query: 297 KITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
+ EE + E + A +EE + L + QI + ++ L+ L+
Sbjct: 4401 MV----EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSS 4456
Query: 357 EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNL------K 410
P D++ + L +P + L+ + +ELI K
Sbjct: 4457 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
Query: 411 PLSDSVIATIQEYQSLKVKSAR--LRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTAS 468
+ D + + ++ +K ++ ++ +EL + F + L Q ++ S
Sbjct: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
Query: 469 LPDLPSLHTFLPQIEAALM---ESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525
PS+ Q+EAA E+ L E L +++ LI G+ + + +
Sbjct: 4577 PGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4634
Query: 526 MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQ 585
+ L+ + +R KL+ + + + + L + +++ + DL +
Sbjct: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
Query: 586 AQLSRLQGLQEEGLDLGAQMEAAR---PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR 642
QL+ ++ + E +ME L+ + + D + L+ E+L ++
Sbjct: 4695 DQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEK 4754
Query: 643 C--RQSVQEHCT-----FSHQLLELRQWIVVTTQKLEAHRGEAG-PGDAESQEAEFERLV 694
RQ E F H L EL W+ T + L+A R +G P E + A+ L
Sbjct: 4755 IAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLK 4814
Query: 695 AEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
+ +A + V G ++E S+ + A+ ++ L + + W ++
Sbjct: 4815 NDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV 4860
Score = 53.5 bits (127), Expect = 9e-07
Identities = 138/790 (17%), Positives = 304/790 (38%), Gaps = 120/790 (15%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +W+ ++ + ++A++ E + + +L + + VD++
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
+ + I +L+ ++++W E ++ ++E + + + E +F
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
Query: 126 YRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIG 185
+K + EP + + Q Q+ + L +++N A + + ++ SL +
Sbjct: 3904 LSVTEKKLANSEP---VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3960
Query: 186 --DPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVVE 241
+ V + ++A Y ++ + ++ LL+Q + G DE ++ WL V +
Sbjct: 3961 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF--GEDEVEVLNWLAEVED 4018
Query: 242 KVNGCLGRNCKLPITQR------------LSTLQDIAKDFPRGE--------ESLETLEE 281
K++ ++ K + R ++ +++ + G+ E + ++E
Sbjct: 4019 KLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 4078
Query: 282 QSAGVIRNTSPL--GAEKITGELEEMRKVLEKLRALWEEEEERLRGL---LRSRGA---- 332
+ G+ + + + K LE+ R++ K ++ +EE LR + L + G
Sbjct: 4079 KLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT 4138
Query: 333 ------WEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
++Q+ K+L+ E+ E R+VL + + ++A E + WR
Sbjct: 4139 GEQIPQFQQRQKELKKEVMEHRLVL-----DTVNEVSRALLE---LVPWRAREG------ 4184
Query: 387 SEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQ 446
+D+L + E K +SD++ + E + +S + AA EL
Sbjct: 4185 -----LDKLVSDANE------QYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL----- 4228
Query: 447 RPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAAL-MESSRLKELLTMLQLKKDL 505
W A +R L + T Q++ A ++ R K+ + L +
Sbjct: 4229 -------AWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281
Query: 506 LIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLL 565
+ G G+E+ T L E+ ++ + + +R ++L+ F +E
Sbjct: 4282 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE------- 4334
Query: 566 DLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQL 625
+L ++ + L LP +L+ QEE M R + E+ H K+ ++
Sbjct: 4335 ELSPWIEETRALIAQLPSPAIDHEQLRQQQEE-------MRQLRESIAEHKPHIDKLLKI 4387
Query: 626 SSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAES 685
+ L ++V+ Q + ++ E+RQ + + + +
Sbjct: 4388 GPQLKELNPEEGEMVEEKYQKAEN--MYAQIKEEVRQRALALDEAV----------SQST 4435
Query: 686 QEAEFERLVAEFPEKEAQLS-------LVEAQGWLVMEKSSPEGAAVVQEELRELAESWR 738
Q EF + E LS L+ A+ + E S +A V EL +L S+
Sbjct: 4436 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV--ELEKLQPSFE 4493
Query: 739 ALRLLEESLL 748
AL+ E L+
Sbjct: 4494 ALKRRGEELI 4503
Score = 50.4 bits (119), Expect = 8e-06
Identities = 115/646 (17%), Positives = 247/646 (38%), Gaps = 80/646 (12%)
Query: 297 KITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
+I ++ ++ EKL + E +E L+ +L ++ + L VL+ +
Sbjct: 2869 EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM-- 2926
Query: 357 EGLQPAAKAGTEDELV-AHWRRYSATRAALASEEPRVDRLQAQLKELIV-FPH-----NL 409
A + T+ E V A A A L P++ +++ L L+V +P+ N
Sbjct: 2927 ----DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
Query: 410 KPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASL 469
K + + + + + + V R +A L FQ L+ W + ++ V L
Sbjct: 2983 KKIQEELNSRWERATEVTVARQRQLEESASHL-ACFQAAESQLRPWLMEKELMMGVLGPL 3041
Query: 470 PDLPS-LHTFLPQIEAALME-SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMR 527
P+ L+ Q++ L E +R ++ + + + +L G +T+ +++ S+
Sbjct: 3042 SIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSIN 3101
Query: 528 DRDL-LHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA 586
+ + L + L R S++ + + + + L K+ + R+ + + +
Sbjct: 3102 QKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQ 3161
Query: 587 QLSRLQGLQEEGLDLGAQMEAARPLVQENP---NHQHKMDQLSSDFQALQ---RSLEDL- 639
QL ++ + L +++ A+ L E Q+ D+L + + + LEDL
Sbjct: 3162 QLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLA 3221
Query: 640 ---VDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDA-----ESQEAEFE 691
++R + ++ F ELR W+ ++ + + P A +SQ E E
Sbjct: 3222 ADRINRLQAALASTQQFQQMFDELRTWL----DDKQSQQAKNCPISAKLERLQSQLQENE 3277
Query: 692 RLVAEFPEKEAQLSLVEAQGWLVMEKSSP-EGAAVVQEELRELAESWRALRLLEESLLSL 750
+ ++ A+G ++ P E +Q +L EL W L S
Sbjct: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
Query: 751 IRN---------WHLQRM-------EVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRAN 794
+++ WH++ + + + V + + L+ + +R +
Sbjct: 3338 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 3397
Query: 795 LLQ---------------EEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLR 839
LL+ +E+G ++ + + +N + + +T + E++
Sbjct: 3398 LLEILNSAADILINSSEADEDGIRDEKAGINQNM--------DAVTEELQAKTGSLEEMT 3449
Query: 840 TRKSKLQE----LEARVPEGQHLFENLLRLGPARGTSDELEDLRYQ 881
R + QE +E +V +H E LG ++ LE LR Q
Sbjct: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQ 3495
Score = 48.9 bits (115), Expect = 2e-05
Identities = 117/658 (17%), Positives = 246/658 (37%), Gaps = 107/658 (16%)
Query: 76 PGD---QKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKM 132
PGD + L+ I +W E + S+I+ + ++Y E + +
Sbjct: 3083 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY----QELLQDLSEK 3138
Query: 133 MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR----IGDPS 188
+ + + +Q + + + + + LD ++EA +L + IG+
Sbjct: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 189 VDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
+ ++ +KR++ ++ A R++ L+ +++Q DE + WL +
Sbjct: 3199 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL----DDKQS 3254
Query: 246 CLGRNCKLPITQRLSTLQ-------DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKI 298
+NC PI+ +L LQ + K + S E + + ++ + P G EK
Sbjct: 3255 QQAKNC--PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP-GEEKR 3311
Query: 299 T--GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRM 349
T +L E++ E+L + + RL+ ++ ++ ++ L +A++SE R+
Sbjct: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 3371
Query: 350 VLQRLAQEGLQPAAKA-------------------------------GTEDELVAHWRRY 378
L + E +KA G DE +
Sbjct: 3372 TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNM 3431
Query: 379 SATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAA 438
A L ++ ++ + +L+E N++ + ++ + +L ++ +N
Sbjct: 3432 DAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 3491
Query: 439 VELWQHFQRPLQ-DLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLT 497
+ Q + L+ + + Q L+E PD L Q E A E
Sbjct: 3492 LRAQQEVLQALEPQVDYLRNFTQGLVE---DAPDGSDASQLLHQAEVAQQE--------- 3539
Query: 498 MLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAF 557
L++K+ + G E + Q +R+ + + L +L + A G
Sbjct: 3540 FLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGA----IGRDT 3592
Query: 558 EPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG----LDLGAQMEAAR---- 609
+ LQ ++ D+++ + L+ D+ +A+ + L+EEG L L ++EA
Sbjct: 3593 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM--LEEEGTLDLLGLKRELEALNKQCG 3650
Query: 610 PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVT 667
L + Q +++ + R L+ L D T + + E QW+V T
Sbjct: 3651 KLTERGKARQEQLELTLGRVEDFYRKLKGLND---------ATTAAEEAEALQWVVGT 3699
Score = 47.8 bits (112), Expect = 5e-05
Identities = 141/762 (18%), Positives = 283/762 (37%), Gaps = 155/762 (20%)
Query: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK-------------AVVEKV 243
+K +Y A+++ + ++ + E +++ EF+ WL+ + E +
Sbjct: 2294 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETL 2353
Query: 244 NGCLGRNCKLP------------ITQRLSTLQDIAKDFPRGEE----------SLETLEE 281
L R +T + D+ F G+E L+ E
Sbjct: 2354 PSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATE 2413
Query: 282 QSAGVIRNTSPLGA--EKITGELEEMRKVLEKLRALWEEEEERLRGLLRSR-----GAWE 334
+ + + LG+ + G+ + + + L+A + E + LL G +
Sbjct: 2414 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 2473
Query: 335 QQI---KQLEAELSEFRMVLQRLAQ--------EGLQPAAK----AGTEDELVAHWR--- 376
+Q+ KQL+ EL+E ++ +++L + EG +PA T D +++H++
Sbjct: 2474 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG-EPAPDHRHVQETTDSILSHFQSLS 2532
Query: 377 -----RYSATRAALASEEPRVDRLQAQLKELIVFPHNL--KPLSDSVIATIQEYQSLKVK 429
R S + A+A + + L++ L+ + NL K +S IQE + +K
Sbjct: 2533 YSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMK 2592
Query: 430 SARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALME- 488
L Q R L+ + + R +E S T ++ L E
Sbjct: 2593 -----------LKQDIARQKSSLEATREMVTRFMETADS--------TTAAVLQGKLAEV 2633
Query: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
S R ++L Q K+ L + Q + E ++G ++ ++ KS++
Sbjct: 2634 SQRFEQLCLQQQEKESSLKKLLPQ---AEMFEHLSGKLQ-------QFMENKSRM----- 2678
Query: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAA 608
+ +P Q D+ Q + L ++ +Q L L+ L E G ++
Sbjct: 2679 ----LASGNQPDQ----DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2730
Query: 609 RPLVQENPNHQHKMDQLSSDFQALQRSLEDL---VDRCRQSVQEHCTFSHQLLELRQWIV 665
+ HQ ++ L DF LQ+++++ C++ + E F + ++W+
Sbjct: 2731 Q--------HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDE---FRKLVRTFQKWLK 2779
Query: 666 VTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGW----LVMEKSSPE 721
T + + E Q + L+ ++ K + + +G L+ME ++P+
Sbjct: 2780 ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD 2839
Query: 722 GAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTN-NIPKSGFLI 780
L + S + + +H + + M N K G ++
Sbjct: 2840 SQGKTGSILPSVGSS-----------VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
Query: 781 NPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED--- 837
+ R +L E H++ + +L QWL+ + L + AM + T +
Sbjct: 2889 H-----ERQESLQAILNRMEEVHKEANSVL----QWLESKEEVLKSMDAMSSPTKTETVK 2939
Query: 838 --LRTRKSKLQELEARVPEGQHLFENLLRLGPARGTSDELED 877
+ K+ L ELE P+ Q + E L L S E E+
Sbjct: 2940 AQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN 2981
Score = 47.0 bits (110), Expect = 9e-05
Identities = 114/584 (19%), Positives = 233/584 (39%), Gaps = 82/584 (14%)
Query: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPIT 256
+K Y + + K + LEQ + ++Q+ +E WL+ V E++ G++ P
Sbjct: 4083 IKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS---PTG 4139
Query: 257 QRLSTLQ----DIAKDFPRGEESLETLEEQSAGVIRNT---SPLGAEKITGELEEMRKVL 309
+++ Q ++ K+ L+T+ E S ++ + G +K+ + E K++
Sbjct: 4140 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 4199
Query: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
+ + +E + RS+ +EQ A ++E + L L L+ +D
Sbjct: 4200 SD--TIGQRVDEIDAAIQRSQ-QYEQAADAELAWVAETKRKLMALGPIRLE-------QD 4249
Query: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELI--VFPHNLKPLSDSVIATIQEYQSLK 427
+ A + A + + +D L + E+ L + + IQ+Y+++
Sbjct: 4250 QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS 4309
Query: 428 V----KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
+ + ARL A L F ++L W + E A + LPS Q+
Sbjct: 4310 LLNSERYARLERAQV--LVNQFWETYEELSPW------IEETRALIAQLPSPAIDHEQLR 4361
Query: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
E +L+E + + D L+ I Q + L G M + ++ K
Sbjct: 4362 QQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE---LNPEEGEMVE---------EKYQKA 4409
Query: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLD--- 600
+++ AQ K E ++++ L L V + + L L+ L
Sbjct: 4410 ENMYAQIK------EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 4463
Query: 601 LGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL 660
+ A+++ R + +N + ++++L F+AL+R E+L+ R + + ++ + ++ +
Sbjct: 4464 IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD--LAAKEIQDK 4521
Query: 661 RQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK-----EAQLSLVEAQGWLVM 715
+V + ++A AE +E +F V E EK A L+ ++ +V
Sbjct: 4522 LDQMVFFWEDIKAR--------AEEREIKFLD-VLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 716 EKSSP-----------EGAAVVQEELRELAESWRALRLLEESLL 748
+ SP E A ++EE L E +R+L L+
Sbjct: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLI 4616
Score = 38.9 bits (89), Expect = 0.024
Identities = 53/255 (20%), Positives = 92/255 (36%), Gaps = 35/255 (13%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E+ +W+ ++ L G +E L + + + V+ V +
Sbjct: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEE--------------TVTYMTHCHSRIEWVWLH 114
LL GD + +RL+ + WE T+ HS IE L
Sbjct: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
Query: 115 WSEY---LLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
+ L A + L+ H+EL LK K+ NQ +
Sbjct: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE-----------ETYNQLLDKG 4940
Query: 172 RLLEEAASLFNR--IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV 229
RL+ L +R G S E + ++ ++ V +K ++R LE+ E+Q +
Sbjct: 4941 RLM-----LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSL 4995
Query: 230 DEFQLWLKAVVEKVN 244
EF WL + +N
Sbjct: 4996 QEFINWLTLAEQSLN 5010
Score = 35.4 bits (80), Expect = 0.26
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 17/123 (13%)
Query: 19 WMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEALLACCPGD 78
W+ + L+ AL++ + ++ + E RV V+ + M E +LA C D
Sbjct: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPD 5387
Query: 79 QKPGILARLKDIKAQWEETVTYMTHCHSRIE----------------WVWLHWSE-YLLA 121
I + I+A++EE +T+ R+E W+ W+E L+
Sbjct: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 5447
Query: 122 RDE 124
RD+
Sbjct: 5448 RDQ 5450
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 74.7 bits (182), Expect = 4e-13
Identities = 136/697 (19%), Positives = 277/697 (39%), Gaps = 47/697 (6%)
Query: 71 LLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ 130
L+ C +KP + + ++ WE ++E +Y + W
Sbjct: 4113 LIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD 4172
Query: 131 KMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPS-- 188
++ L + L + QL+ + V Q + +++L + + + D +
Sbjct: 4173 NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDR 4232
Query: 189 -VDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGC- 246
+ + +K ++ + K R LE ++Q ++E WL E ++
Sbjct: 4233 DIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQR 4292
Query: 247 -LGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEM 305
+ + K+ I L+ + D + ++ET+ + ++ +++ A + LE M
Sbjct: 4293 PISGDPKV-IEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAM 4351
Query: 306 RKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKA 365
+ E + EE E++L+ L+ + +I+ EL+ L G P
Sbjct: 4352 NQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPET-- 4409
Query: 366 GTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ- 424
++L H YS +A + +D+ + L K SV Q++
Sbjct: 4410 -AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKT-EQSVALLEQKWHV 4467
Query: 425 -SLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
S K++ + + A+ L FQ LQ+ W LA++ L + AS P L L+T L QIE
Sbjct: 4468 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI-ASPPSL-ILNTVLSQIE 4525
Query: 484 AALMESSRLK----ELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDR-DLLHNSLLQ 538
+ ++ + +++ + Q L Q++ L++ + S++ R + + ++
Sbjct: 4526 EHKVFANEVNAHRDQIIELDQTGNQL--KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIE 4583
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG 598
R L + K F A++ L L D + + +E + D + QLS+ + Q+
Sbjct: 4584 RGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK-- 4641
Query: 599 LDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR----CRQSV------Q 648
LG + ++ + K L D Q L L ++ D+ C +SV +
Sbjct: 4642 -TLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
Query: 649 EHCTFSHQLLELRQWIVVTTQKLEAHRGEAGP--GDAE------SQEAEFERLVAEFPEK 700
E FS Q ++ Q +V K+E E P GD + F++ E ++
Sbjct: 4700 EALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQK---ELGKR 4756
Query: 701 EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESW 737
+ +++ G ++E +S + V+ +L+EL+ W
Sbjct: 4757 TGTVQVLKRSGRELIE-NSRDDTTWVKGQLQELSTRW 4792
Score = 70.9 bits (172), Expect = 6e-12
Identities = 201/1036 (19%), Positives = 373/1036 (36%), Gaps = 183/1036 (17%)
Query: 2 TQQPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRV 61
TQQ Q FD + + W+ Q Q N L+++L E E+ + +
Sbjct: 2733 TQQFQQMFD----ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
Query: 62 DLVLRMAEALLACCP-GDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLL 120
++++ E+LL P G++K + +L ++K WEE SR++ +Y
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848
Query: 121 ARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL 180
++ W + + + + L + + L ++ +L+ V+ + LL+ +L AA +
Sbjct: 2849 HVEDLVPWIEDCKAKMS-ELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLE-ILNSAADI 2906
Query: 181 FNRIGDPSVDEDAQKRMKA----EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWL 236
I DED + KA DAV + Q + LE++ + E+Q + +
Sbjct: 2907 L--INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 2964
Query: 237 KAVVEKV--------NGCLGRN-----CKLPITQRLSTLQDIAKDFPRG----------- 272
+ ++ C +N + + Q L D ++F +G
Sbjct: 2965 EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3024
Query: 273 -----------EESLETLEEQSAGVIRNTSPL---------------------------- 293
+E LE + ++G + + L
Sbjct: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMG 3084
Query: 294 ----GAEKITGELEEMRKVLEKLRA---------------LWEEEEERLRGLLRSRGAWE 334
+ + ++E++R L K+ L EE L GL R A
Sbjct: 3085 AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALN 3144
Query: 335 QQIKQL----EAELSEFRMVLQRLAQ-----EGLQPAAKAGTEDELVAHW---RRYSATR 382
+Q +L +A + + L R+ +GL A A E E + W
Sbjct: 3145 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL-QWVVGTEVEIIN 3203
Query: 383 AALAS----EEPRVDRLQAQLKELIVFPHNL----------KPLSDSVIATIQEYQSLKV 428
LA ++ +VD LQ +L+++ L + L + + +L
Sbjct: 3204 QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
Query: 429 KSARLRNAAAVELWQH---FQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAA 485
K A+ R A E H FQ L+ L W A + L+ + PS ++A
Sbjct: 3264 KVAQ-RIAQLQEALLHCGKFQDALEPLLSWLADTEELI----ANQKPPSAE--YKVVKAQ 3316
Query: 486 LMESSRLKELLTMLQLKKDLLI---GIFGQERATALLEQVAGSMRDRDLLHNSLLQ---- 538
+ E L+ LL + D+L G Q A E++ G + + LL
Sbjct: 3317 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3376
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG 598
R+ +L+ +L K F EP+ L + ++ + + Q Q+ R + L+E+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 599 LDLGAQMEAARPLVQENPNHQHKMDQ--LSSDFQALQRSLEDLVDRC-------RQSVQE 649
+ + A + Q + +Q LS +LQ ++ DRC Q++
Sbjct: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSN 3496
Query: 650 HCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVE 708
F +E+ W+ KL + + D Q A+ L E ++ +
Sbjct: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
Query: 709 AQGWLVMEKSSPEGAAVVQEELREL--------AESWRALRLLEESLLSLIRNWHLQRME 760
G ++++++ E ++QE+L + S +ALR LE++ L + E
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQA-RQLATKFQSTYEE 3615
Query: 761 VDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSH-------EDFSQLLRNF 813
+ + V + SG + IP+ ++R L++E H + S+ L
Sbjct: 3616 LTGWLREV-EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL 3674
Query: 814 GQWLQVEN-SKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFE------------ 860
W E KLV + D T ++ E++A + Q +
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSD--TIGQRVDEIDAAIQRSQQYEQAADAELAWVAET 3732
Query: 861 --NLLRLGPARGTSDE 874
L+ LGP R D+
Sbjct: 3733 KRKLMALGPIRLEQDQ 3748
Score = 69.7 bits (169), Expect = 1e-11
Identities = 161/854 (18%), Positives = 326/854 (38%), Gaps = 119/854 (13%)
Query: 86 RLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLG 145
+LKD ++ + T S + + + ++ + D W Q +E + +
Sbjct: 1905 KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVA 1964
Query: 146 LKEK--QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD----EDAQKRMKA 199
Q QL+ + L + V +++L + A + G+P+ D ++ + +
Sbjct: 1965 SDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILS 2024
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQR- 258
+ ++ +R LL++ + + Q ++ + V + + G + + Q
Sbjct: 2025 HFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA 2084
Query: 259 LSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEE 318
L+T + +D R + SLE E + A + G+L E+ + E+L +E
Sbjct: 2085 LATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQE 2144
Query: 319 EEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRY 378
+E L+ LL + + L +L +F R+ G QP + ++ +++
Sbjct: 2145 KESSLKKLLPQ----AEMFEHLSGKLQQFMENKSRMLASGNQP------DQDITHFFQQI 2194
Query: 379 SATRAALASEEPRVDRLQAQLKEL--IVFPHNLKPLSDSVIATIQEYQSLK--VKSARLR 434
+ ++ +D L+ + EL F +L D V +++ L+ VK
Sbjct: 2195 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD 2254
Query: 435 NAAAVELWQHFQRPLQDLQLW-----------------KALAQRLLEVTASLPDLPSLHT 477
++ E F++ ++ Q W K L +++ + + L D S T
Sbjct: 2255 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT 2314
Query: 478 FLPQI--EAALMESSRLKELLTMLQLKKDLLIGIFGQERATAL-------LEQVAGSMRD 528
+ +I + +E+ ++ Q K ++ G + L ++ M D
Sbjct: 2315 LVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2374
Query: 529 RDL----LHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQRD 580
+L L L +R+ LQ++L + HK+ + + L+ K L+ + +
Sbjct: 2375 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2434
Query: 581 LPGKQAQLSR--LQGLQEEGLDLGAQMEAARPLVQENPNHQHK------MDQLSSDFQAL 632
QA+ ++ L L++ + EA L+ PN Q ++L+S +
Sbjct: 2435 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW--- 2491
Query: 633 QRSLEDLVDRCRQ---SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAE----- 684
+R+ E V R RQ S F +LR W++ + E G GP +
Sbjct: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLM----EKELMMGVLGPLSIDPNMLN 2547
Query: 685 SQEAEFERLVAEFPEKEAQLSLVE--AQGWLVMEKSSPEGAAVVQEELRELAESWRALRL 742
+Q+ + + ++ EF + Q + AQG L + VQ+EL+ + + W
Sbjct: 2548 AQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKW----- 2602
Query: 743 LEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS 802
+ L + + ++D I + + LLQ
Sbjct: 2603 -----VELTDKLNSRSSQIDQA---------------------IVKSTQYQELLQ----- 2631
Query: 803 HEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENL 862
D S+ +R GQ L V+++ + A++ E R S L++L+ V E Q L + L
Sbjct: 2632 --DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR-SDLEQLDHEVKEAQTLCDEL 2688
Query: 863 LRLGPARGTSDELE 876
L + DEL+
Sbjct: 2689 SVLIGEQYLKDELK 2702
Score = 54.7 bits (130), Expect = 4e-07
Identities = 134/766 (17%), Positives = 295/766 (38%), Gaps = 50/766 (6%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEP-EGRVRVDLVLRM 67
F + E+ W++ V+++L + Q P + + +K + E E R+ +D V +
Sbjct: 3609 FQSTYEELTGWLREVEEELATSGG-QSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 3667
Query: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
+ ALL P + G+ + D Q++ + I+ +Y A D
Sbjct: 3668 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 3727
Query: 128 WF----QKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
W +K+M +E + Q Q + + ++ + D+ +D L + +F
Sbjct: 3728 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDS----MDELFSHRSEIFGT 3783
Query: 184 IGDP--SVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKA--- 238
G+ +V ++ + + +Y+A+ +R LE+ ++ +E W++
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 3843
Query: 239 -VVEKVNGCLGRNCKLPITQRLSTLQD-IAKDFPRGEESLETLEEQSAGVIRNTSPLGAE 296
+ + + + + + L++ IA+ P ++ L+ + ++ +P E
Sbjct: 3844 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-----LKELNPEEGE 3898
Query: 297 KITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
+ EE + E + A +EE + L + QI + ++ L+ L+
Sbjct: 3899 MV----EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSS 3954
Query: 357 EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNL------K 410
P D++ + L +P + L+ + +ELI K
Sbjct: 3955 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
Query: 411 PLSDSVIATIQEYQSLKVKSAR--LRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTAS 468
+ D + + ++ +K ++ ++ +EL + F + L Q ++ S
Sbjct: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
Query: 469 LPDLPSLHTFLPQIEAALM---ESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525
PS+ Q+EAA E+ L E L +++ LI G+ + + +
Sbjct: 4075 PGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4132
Query: 526 MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQ 585
+ L+ + +R KL+ + + + + L + +++ + DL +
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
Query: 586 AQLSRLQGLQEEGLDLGAQMEAAR---PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR 642
QL+ ++ + E +ME L+ + + D + L+ E+L ++
Sbjct: 4193 DQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEK 4252
Query: 643 C--RQSVQEHCT-----FSHQLLELRQWIVVTTQKLEAHRGEAG-PGDAESQEAEFERLV 694
RQ E F H L EL W+ T + L+A R +G P E + A+ L
Sbjct: 4253 IAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLK 4312
Query: 695 AEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
+ +A + V G ++E S+ + A+ ++ L + + W ++
Sbjct: 4313 NDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESV 4358
Score = 53.5 bits (127), Expect = 9e-07
Identities = 138/790 (17%), Positives = 304/790 (38%), Gaps = 120/790 (15%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E +W+ ++ + ++A++ E + + +L + + VD++
Sbjct: 3282 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3341
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWL---HWSEYLLARDEF 125
+ + I +L+ ++++W E ++ ++E + + + E +F
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401
Query: 126 YRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIG 185
+K + EP + + Q Q+ + L +++N A + + ++ SL +
Sbjct: 3402 LSVTEKKLANSEP---VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTS 3458
Query: 186 --DPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQL--WLKAVVE 241
+ V + ++A Y ++ + ++ LL+Q + G DE ++ WL V +
Sbjct: 3459 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF--GEDEVEVLNWLAEVED 3516
Query: 242 KVNGCLGRNCKLPITQR------------LSTLQDIAKDFPRGE--------ESLETLEE 281
K++ ++ K + R ++ +++ + G+ E + ++E
Sbjct: 3517 KLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQE 3576
Query: 282 QSAGVIRNTSPL--GAEKITGELEEMRKVLEKLRALWEEEEERLRGL---LRSRGA---- 332
+ G+ + + + K LE+ R++ K ++ +EE LR + L + G
Sbjct: 3577 KLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT 3636
Query: 333 ------WEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
++Q+ K+L+ E+ E R+VL + + ++A E + WR
Sbjct: 3637 GEQIPQFQQRQKELKKEVMEHRLVL-----DTVNEVSRALLE---LVPWRAREG------ 3682
Query: 387 SEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQ 446
+D+L + E K +SD++ + E + +S + AA EL
Sbjct: 3683 -----LDKLVSDANE------QYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL----- 3726
Query: 447 RPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAAL-MESSRLKELLTMLQLKKDL 505
W A +R L + T Q++ A ++ R K+ + L +
Sbjct: 3727 -------AWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 3779
Query: 506 LIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLL 565
+ G G+E+ T L E+ ++ + + +R ++L+ F +E
Sbjct: 3780 IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYE------- 3832
Query: 566 DLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQL 625
+L ++ + L LP +L+ QEE M R + E+ H K+ ++
Sbjct: 3833 ELSPWIEETRALIAQLPSPAIDHEQLRQQQEE-------MRQLRESIAEHKPHIDKLLKI 3885
Query: 626 SSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAES 685
+ L ++V+ Q + ++ E+RQ + + + +
Sbjct: 3886 GPQLKELNPEEGEMVEEKYQKAEN--MYAQIKEEVRQRALALDEAV----------SQST 3933
Query: 686 QEAEFERLVAEFPEKEAQLS-------LVEAQGWLVMEKSSPEGAAVVQEELRELAESWR 738
Q EF + E LS L+ A+ + E S +A V EL +L S+
Sbjct: 3934 QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV--ELEKLQPSFE 3991
Query: 739 ALRLLEESLL 748
AL+ E L+
Sbjct: 3992 ALKRRGEELI 4001
Score = 50.4 bits (119), Expect = 8e-06
Identities = 115/646 (17%), Positives = 247/646 (38%), Gaps = 80/646 (12%)
Query: 297 KITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQ 356
+I ++ ++ EKL + E +E L+ +L ++ + L VL+ +
Sbjct: 2367 EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM-- 2424
Query: 357 EGLQPAAKAGTEDELV-AHWRRYSATRAALASEEPRVDRLQAQLKELIV-FPH-----NL 409
A + T+ E V A A A L P++ +++ L L+V +P+ N
Sbjct: 2425 ----DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2480
Query: 410 KPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASL 469
K + + + + + + V R +A L FQ L+ W + ++ V L
Sbjct: 2481 KKIQEELNSRWERATEVTVARQRQLEESASHL-ACFQAAESQLRPWLMEKELMMGVLGPL 2539
Query: 470 PDLPS-LHTFLPQIEAALME-SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMR 527
P+ L+ Q++ L E +R ++ + + + +L G +T+ +++ S+
Sbjct: 2540 SIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSIN 2599
Query: 528 DRDL-LHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA 586
+ + L + L R S++ + + + + L K+ + R+ + + +
Sbjct: 2600 QKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQ 2659
Query: 587 QLSRLQGLQEEGLDLGAQMEAARPLVQENP---NHQHKMDQLSSDFQALQ---RSLEDL- 639
QL ++ + L +++ A+ L E Q+ D+L + + + LEDL
Sbjct: 2660 QLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLA 2719
Query: 640 ---VDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDA-----ESQEAEFE 691
++R + ++ F ELR W+ ++ + + P A +SQ E E
Sbjct: 2720 ADRINRLQAALASTQQFQQMFDELRTWL----DDKQSQQAKNCPISAKLERLQSQLQENE 2775
Query: 692 RLVAEFPEKEAQLSLVEAQGWLVMEKSSP-EGAAVVQEELRELAESWRALRLLEESLLSL 750
+ ++ A+G ++ P E +Q +L EL W L S
Sbjct: 2776 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 2835
Query: 751 IRN---------WHLQRM-------EVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRAN 794
+++ WH++ + + + V + + L+ + +R +
Sbjct: 2836 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 2895
Query: 795 LLQ---------------EEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLR 839
LL+ +E+G ++ + + +N + + +T + E++
Sbjct: 2896 LLEILNSAADILINSSEADEDGIRDEKAGINQNM--------DAVTEELQAKTGSLEEMT 2947
Query: 840 TRKSKLQE----LEARVPEGQHLFENLLRLGPARGTSDELEDLRYQ 881
R + QE +E +V +H E LG ++ LE LR Q
Sbjct: 2948 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQ 2993
Score = 48.9 bits (115), Expect = 2e-05
Identities = 117/658 (17%), Positives = 246/658 (37%), Gaps = 107/658 (16%)
Query: 76 PGD---QKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKM 132
PGD + L+ I +W E + S+I+ + ++Y E + +
Sbjct: 2581 PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQY----QELLQDLSEK 2636
Query: 133 MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR----IGDPS 188
+ + + +Q + + + + + LD ++EA +L + IG+
Sbjct: 2637 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 2696
Query: 189 VDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
+ ++ +KR++ ++ A R++ L+ +++Q DE + WL +
Sbjct: 2697 LKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL----DDKQS 2752
Query: 246 CLGRNCKLPITQRLSTLQ-------DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKI 298
+NC PI+ +L LQ + K + S E + + ++ + P G EK
Sbjct: 2753 QQAKNC--PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP-GEEKR 2809
Query: 299 T--GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQL-------EAELSEFRM 349
T +L E++ E+L + + RL+ ++ ++ ++ L +A++SE R+
Sbjct: 2810 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV 2869
Query: 350 VLQRLAQEGLQPAAKA-------------------------------GTEDELVAHWRRY 378
L + E +KA G DE +
Sbjct: 2870 TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNM 2929
Query: 379 SATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAA 438
A L ++ ++ + +L+E N++ + ++ + +L ++ +N
Sbjct: 2930 DAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEK 2989
Query: 439 VELWQHFQRPLQ-DLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLT 497
+ Q + L+ + + Q L+E PD L Q E A E
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVE---DAPDGSDASQLLHQAEVAQQE--------- 3037
Query: 498 MLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAF 557
L++K+ + G E + Q +R+ + + L +L + A G
Sbjct: 3038 FLEVKQRVNSGCVMMENKLEGIGQFHCRVRE---MFSQLADLDDELDGMGA----IGRDT 3090
Query: 558 EPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEG----LDLGAQMEAAR---- 609
+ LQ ++ D+++ + L+ D+ +A+ + L+EEG L L ++EA
Sbjct: 3091 DSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM--LEEEGTLDLLGLKRELEALNKQCG 3148
Query: 610 PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVT 667
L + Q +++ + R L+ L D T + + E QW+V T
Sbjct: 3149 KLTERGKARQEQLELTLGRVEDFYRKLKGLND---------ATTAAEEAEALQWVVGT 3197
Score = 47.8 bits (112), Expect = 5e-05
Identities = 141/762 (18%), Positives = 283/762 (37%), Gaps = 155/762 (20%)
Query: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLK-------------AVVEKV 243
+K +Y A+++ + ++ + E +++ EF+ WL+ + E +
Sbjct: 1792 LKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETL 1851
Query: 244 NGCLGRNCKLP------------ITQRLSTLQDIAKDFPRGEE----------SLETLEE 281
L R +T + D+ F G+E L+ E
Sbjct: 1852 PSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATE 1911
Query: 282 QSAGVIRNTSPLGA--EKITGELEEMRKVLEKLRALWEEEEERLRGLLRSR-----GAWE 334
+ + + LG+ + G+ + + + L+A + E + LL G +
Sbjct: 1912 RYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQ 1971
Query: 335 QQI---KQLEAELSEFRMVLQRLAQ--------EGLQPAAK----AGTEDELVAHWR--- 376
+Q+ KQL+ EL+E ++ +++L + EG +PA T D +++H++
Sbjct: 1972 EQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG-EPAPDHRHVQETTDSILSHFQSLS 2030
Query: 377 -----RYSATRAALASEEPRVDRLQAQLKELIVFPHNL--KPLSDSVIATIQEYQSLKVK 429
R S + A+A + + L++ L+ + NL K +S IQE + +K
Sbjct: 2031 YSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMK 2090
Query: 430 SARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALME- 488
L Q R L+ + + R +E S T ++ L E
Sbjct: 2091 -----------LKQDIARQKSSLEATREMVTRFMETADS--------TTAAVLQGKLAEV 2131
Query: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
S R ++L Q K+ L + Q + E ++G ++ ++ KS++
Sbjct: 2132 SQRFEQLCLQQQEKESSLKKLLPQ---AEMFEHLSGKLQ-------QFMENKSRM----- 2176
Query: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAA 608
+ +P Q D+ Q + L ++ +Q L L+ L E G ++
Sbjct: 2177 ----LASGNQPDQ----DITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2228
Query: 609 RPLVQENPNHQHKMDQLSSDFQALQRSLEDL---VDRCRQSVQEHCTFSHQLLELRQWIV 665
+ HQ ++ L DF LQ+++++ C++ + E F + ++W+
Sbjct: 2229 Q--------HQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDE---FRKLVRTFQKWLK 2277
Query: 666 VTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGW----LVMEKSSPE 721
T + + E Q + L+ ++ K + + +G L+ME ++P+
Sbjct: 2278 ETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD 2337
Query: 722 GAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTN-NIPKSGFLI 780
L + S + + +H + + M N K G ++
Sbjct: 2338 SQGKTGSILPSVGSS-----------VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
Query: 781 NPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED--- 837
+ R +L E H++ + +L QWL+ + L + AM + T +
Sbjct: 2387 H-----ERQESLQAILNRMEEVHKEANSVL----QWLESKEEVLKSMDAMSSPTKTETVK 2437
Query: 838 --LRTRKSKLQELEARVPEGQHLFENLLRLGPARGTSDELED 877
+ K+ L ELE P+ Q + E L L S E E+
Sbjct: 2438 AQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAEN 2479
Score = 47.0 bits (110), Expect = 9e-05
Identities = 114/584 (19%), Positives = 233/584 (39%), Gaps = 82/584 (14%)
Query: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPIT 256
+K Y + + K + LEQ + ++Q+ +E WL+ V E++ G++ P
Sbjct: 3581 IKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS---PTG 3637
Query: 257 QRLSTLQ----DIAKDFPRGEESLETLEEQSAGVIRNT---SPLGAEKITGELEEMRKVL 309
+++ Q ++ K+ L+T+ E S ++ + G +K+ + E K++
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
Query: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
+ + +E + RS+ +EQ A ++E + L L L+ +D
Sbjct: 3698 SD--TIGQRVDEIDAAIQRSQ-QYEQAADAELAWVAETKRKLMALGPIRLE-------QD 3747
Query: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELI--VFPHNLKPLSDSVIATIQEYQSLK 427
+ A + A + + +D L + E+ L + + IQ+Y+++
Sbjct: 3748 QTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAIS 3807
Query: 428 V----KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
+ + ARL A L F ++L W + E A + LPS Q+
Sbjct: 3808 LLNSERYARLERAQV--LVNQFWETYEELSPW------IEETRALIAQLPSPAIDHEQLR 3859
Query: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
E +L+E + + D L+ I Q + L G M + ++ K
Sbjct: 3860 QQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE---LNPEEGEMVE---------EKYQKA 3907
Query: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLD--- 600
+++ AQ K E ++++ L L V + + L L+ L
Sbjct: 3908 ENMYAQIK------EEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 3961
Query: 601 LGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL 660
+ A+++ R + +N + ++++L F+AL+R E+L+ R + + ++ + ++ +
Sbjct: 3962 IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD--LAAKEIQDK 4019
Query: 661 RQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK-----EAQLSLVEAQGWLVM 715
+V + ++A AE +E +F V E EK A L+ ++ +V
Sbjct: 4020 LDQMVFFWEDIKAR--------AEEREIKFLD-VLELAEKFWYDMAALLTTIKDTQDIVH 4070
Query: 716 EKSSP-----------EGAAVVQEELRELAESWRALRLLEESLL 748
+ SP E A ++EE L E +R+L L+
Sbjct: 4071 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLI 4114
Score = 38.9 bits (89), Expect = 0.024
Identities = 53/255 (20%), Positives = 92/255 (36%), Gaps = 35/255 (13%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F ++E+ +W+ ++ L G +E L + + + V+ V +
Sbjct: 4270 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4329
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEE--------------TVTYMTHCHSRIEWVWLH 114
LL GD + +RL+ + WE T+ HS IE L
Sbjct: 4330 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
Query: 115 WSEY---LLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
+ L A + L+ H+EL LK K+ NQ +
Sbjct: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKE-----------ETYNQLLDKG 4438
Query: 172 RLLEEAASLFNR--IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV 229
RL+ L +R G S E + ++ ++ V +K ++R LE+ E+Q +
Sbjct: 4439 RLM-----LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSL 4493
Query: 230 DEFQLWLKAVVEKVN 244
EF WL + +N
Sbjct: 4494 QEFINWLTLAEQSLN 4508
Score = 35.4 bits (80), Expect = 0.26
Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 17/123 (13%)
Query: 19 WMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEALLACCPGD 78
W+ + L+ AL++ + ++ + E RV V+ + M E +LA C D
Sbjct: 4826 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPD 4885
Query: 79 QKPGILARLKDIKAQWEETVTYMTHCHSRIE----------------WVWLHWSE-YLLA 121
I + I+A++EE +T+ R+E W+ W+E L+
Sbjct: 4886 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 4945
Query: 122 RDE 124
RD+
Sbjct: 4946 RDQ 4948
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1629 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1672
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1673 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1724
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1783
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1784 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1835 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2184
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2185 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2233
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2234 RVQMEELSKLKARI 2247
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2101 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2151
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2152 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2331 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2390 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2442 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2493
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2494 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2669 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2727
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2728 ILLEAQAASGFLLDPV----RNRR 2747
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 907 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 963
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1019
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1196
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1397 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1456
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1572
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1633 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1676
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1677 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1728
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1787
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1788 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1839 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 2016 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2074 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2188
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2189 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2237
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2238 RVQMEELSKLKARI 2251
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2105 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2155
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2156 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2274
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2335 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2394 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2446 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2497
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2498 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2613 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2672
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2673 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2731
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2732 ILLEAQAASGFLLDPV----RNRR 2751
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 911 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 967
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 968 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1023
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1024 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1083
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1084 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1143
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1144 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1200
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1201 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1260
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1261 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1320
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1498
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1629 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1672
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1673 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1724
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1783
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1784 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1835 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2070 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2184
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2185 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2233
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2234 RVQMEELSKLKARI 2247
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2101 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2151
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2152 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2331 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2390 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2442 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2493
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2494 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2668
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2669 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2727
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2728 ILLEAQAASGFLLDPV----RNRR 2747
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 907 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 963
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1019
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1196
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1197 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1256
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1257 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1494
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1361 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1420
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1536
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1597 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1640
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1641 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1692
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1751
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1752 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1803 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 1980 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2038 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2152
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2153 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2201
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2202 RVQMEELSKLKARI 2215
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2069 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2119
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2120 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2238
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2299 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2358 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2410 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2461
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2462 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2577 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2636
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2637 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2695
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2696 ILLEAQAASGFLLDPV----RNRR 2715
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 875 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 931
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 932 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 987
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 988 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1107
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1108 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1164
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1165 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1224
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1225 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1284
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1462
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1530 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1705
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1766 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1809
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1810 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1861
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1920
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1921 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1972 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 2149 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2207 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2321
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2322 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2370
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2371 RVQMEELSKLKARI 2384
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2238 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2288
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2289 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2468 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2527 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2579 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2630
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2631 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2746 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2805
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2806 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2864
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2865 ILLEAQAASGFLLDPV----RNRR 2884
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 1044 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 1100
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 1101 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1156
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1157 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1216
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1217 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1276
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1277 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1333
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1334 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1393
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1394 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1453
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1631
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1371 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1546
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1607 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1650
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1651 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1702
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1761
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1762 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1813 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 1990 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2048 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2162
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2163 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2211
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2212 RVQMEELSKLKARI 2225
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2079 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2129
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2130 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2248
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2309 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2368 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2420 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2471
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2472 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2587 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2646
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2647 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2705
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2706 ILLEAQAASGFLLDPV----RNRR 2725
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 885 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 941
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 942 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 997
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 998 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1057
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1058 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1117
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1118 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1174
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1175 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1234
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1235 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1294
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1472
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1379 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1438
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1439 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1554
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1615 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1658
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1659 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1710
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1769
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1770 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1821 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 1998 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2056 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2170
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2171 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2219
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2220 RVQMEELSKLKARI 2233
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2087 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2137
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2138 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2256
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2317 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2376 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2428 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2479
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2480 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2595 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2654
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2655 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2713
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2714 ILLEAQAASGFLLDPV----RNRR 2733
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 893 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 949
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 950 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1005
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1006 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1065
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1066 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1125
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1126 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1182
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1183 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1242
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1243 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1302
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1480
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 73.2 bits (178), Expect = 1e-12
Identities = 207/914 (22%), Positives = 356/914 (38%), Gaps = 121/914 (13%)
Query: 1 MTQQPQDDFDRSVE---DAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEG 57
+ Q+ Q++ R E DAQ +++Q++LQ + +AR E + +L E
Sbjct: 1420 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
Query: 58 RVR-VDLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIE------- 109
+R V L L E G+ + + AR ++ +AQ + +++
Sbjct: 1480 EIRVVRLQLEATERQRGGAEGELQ-ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538
Query: 110 WVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVL 169
+ + + A E R Q+ + LE EL+L +E + +L A+V A+
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALE---ELRLQAEEAERRLRQAEVERARQVQVALE 1595
Query: 170 LDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAV---KAKAQKRVDLLEQVAREHEEYQ 226
+ EA R ++ ++ E+ AV + +A++R + R EE +
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655
Query: 227 AGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGV 286
++ +QL K N L + +++A+ + E +E++
Sbjct: 1656 RELERWQL-------KANEALRLRLQ---------AEEVAQQKSLAQAEAEKQKEEAERE 1699
Query: 287 IRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE 346
R E+ + E + LEK R L E G + R A EQ++ +L AE +
Sbjct: 1700 ARRRGK-AEEQAVRQRELAEQELEKQRQLAE-------GTAQQRLAAEQELIRLRAETEQ 1751
Query: 347 FRMVLQRLAQE--GLQPAAKAGTE--DELVAHWRRYSATRAALASEEPRVDRLQAQLKEL 402
Q L +E LQ A A T+ EL A + A L + + R + E
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE- 1810
Query: 403 IVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRL 462
+ A ++ L ++ARLR A A E + Q +D +A A+R+
Sbjct: 1811 --------KSKQRLEAEAGRFRELAEEAARLR-ALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 463 L-EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML---------QLKKDLLIGIFGQ 512
L E A++ + L T + E AL E E L L +L++
Sbjct: 1862 LAEKLAAIGEATRLKT---EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 513 ERATALLEQVAGS--MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL-QV 569
E A L + + S R + L+ ++L QR+ + +LA F A L+L ++
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 570 RVQAEKGL----QRDL-PGKQAQLS------RLQGLQEEGLDLGAQMEAAR--------- 609
R AE L Q +L +Q QL+ R + + L A+ EAAR
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 610 ----PLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC-TFSHQLLELRQWI 664
V+E + + +Q S+ + LQ + E R + + H + EL+Q +
Sbjct: 2039 ERLKAKVEEARRLRERAEQESA--RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 665 VVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAA 724
L+ RGEA ++EAE R+ AE +++ + EA+ + + A
Sbjct: 2097 QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156
Query: 725 VVQ---EELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
Q E+LR+ AE A R E + +R E++ KK K+
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQ--AALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2211
Query: 782 PMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDL--- 838
LQ EE H+ LL Q L+ E ++ R R+ E+L
Sbjct: 2212 ------EQELTTLRLQLEETDHQ--KNLLDEELQRLKAEATEAAR---QRSQVEEELFSV 2260
Query: 839 RTRKSKLQELEARV 852
R + +L +L+AR+
Sbjct: 2261 RVQMEELSKLKARI 2274
Score = 57.4 bits (137), Expect = 6e-08
Identities = 147/684 (21%), Positives = 277/684 (40%), Gaps = 93/684 (13%)
Query: 164 DNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE 223
+ +A R +EEA L S +E AQ R +A+ A K + + ++ AR +
Sbjct: 2128 EREAAQSRRQVEEAERL-----KQSAEEQAQARAQAQAAAEKLRKEAE----QEAARRAQ 2178
Query: 224 EYQAGVDEFQLWLKAVVEKVNGCLGRNC--KLPITQRLSTLQDIAKDFPRG----EESLE 277
QA + + Q A +EK + K + Q L+TL+ ++ +E L+
Sbjct: 2179 AEQAALRQKQA-ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 278 TLEEQSAGVIRNTSPLGAE--KITGELEEMRKVLEKLRA---------------LWEEEE 320
L+ ++ R S + E + ++EE+ K+ ++ A +EE
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297
Query: 321 ERLRGLLR-----SRGAWEQ-QIKQL-EAELSEFRMVLQRLAQE---GLQPAAKAGTEDE 370
E+++ + S A E +++QL E +L++ R + +++ +E +Q A + E E
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 371 LVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
L+ + + +A E+ + Q +E F L+ + E + LK++
Sbjct: 2358 LLQQQKELAQEQARRLQED-KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2416
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVT-----ASLPDLPSLHTFLPQIEAA 485
A + A A R +D Q ++ A+ + E A+ + + T Q + +
Sbjct: 2417 AEMSRAQA--------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468
Query: 486 LMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQS 545
++ RL+E + L+ +K+ L ++ LL+ + M+ + LLQ LQ
Sbjct: 2469 DHDAERLREAIAELEREKEKL------QQEAKLLQLKSEEMQT--VQQEQLLQETQALQQ 2520
Query: 546 LLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQA----QLSRLQGLQEEGLDL 601
KD LQR+ Q + + E+ Q ++ Q Q + Q +++E L
Sbjct: 2521 SFLSEKD-----SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
Query: 602 GAQMEAARPLVQENPN----HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTF 653
A ME AR E Q ++ QL + + L + R R+ +Q +H
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Query: 654 SHQLLELRQWIVVTTQKL----EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
E+ V T+ L +A G A + E R V+ +EA + E
Sbjct: 2636 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEE 2695
Query: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALR--LLEESLLSLIRNWHLQRMEVDSGKKM 767
L ++ + A +E++R + ++ LL+ + L LQR + G +
Sbjct: 2696 LQRLAQGHTTVDELAR-REDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTAL 2754
Query: 768 VFTNNIPKSGFLINPMDPIPRHRR 791
+ SGFL++P+ R+RR
Sbjct: 2755 ILLEAQAASGFLLDPV----RNRR 2774
Score = 55.5 bits (132), Expect = 2e-07
Identities = 143/646 (22%), Positives = 250/646 (38%), Gaps = 61/646 (9%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAE--YDAVKA 206
+ W L+ + L QA+ LE F R + + R+ AE Y +
Sbjct: 934 RSWSLATFRTLKPEEQRQAL---HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSH 990
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC---KLPI-------- 255
Q+ + LEQ A+E Q + E LK + ++ C R +LP+
Sbjct: 991 HYQQLLQSLEQGAQEESRCQRCISE----LKDIRLQLEACETRTVHRLRLPLDKEPAREC 1046
Query: 256 TQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPL-GAEKITGELEEMRKVLEKLRA 314
QR++ Q + + + L ++ V+ P A + ELE LE++R+
Sbjct: 1047 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1106
Query: 315 LWEEEEERLRGL---LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
L E+L+ + +R E+ ++ E +L E + V L + A+ +
Sbjct: 1107 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1166
Query: 372 VAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS- 430
A + A R L + +RLQ + E V ++ + V ++ +Q++ ++
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQRHGERDV---EVERWRERVAQLLERWQAVLAQTD 1223
Query: 431 ARLRNAAAVELWQHFQRPLQD-LQLWKALAQRLLEVTASLP--DLPSLHTFLPQIEAALM 487
R R + + R D L W A+R E ++P D ++ L Q +A L
Sbjct: 1224 VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE 1283
Query: 488 ESSRLKELLTMLQ-LKKDLLIGIFGQERAT----ALLEQVAGSMRDRDLLHNS------- 535
E R E + Q K + I E A LE VA + + S
Sbjct: 1284 EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1343
Query: 536 --LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQG 593
L S+L +L +Q+ F + E L+R + ++ Q + L +A L + +
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFIS--ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
Query: 594 LQEEGLDLGAQMEA-ARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHC- 651
L E AQ E A+ L Q + ++ + D Q +RS+++ + + RQS +
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461
Query: 652 -------TFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL 704
L + + I V +LEA + G + E Q AE +++AQ
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQE 1521
Query: 705 SLVEAQGWLVME-----KSSPEGAAVVQEELRELAESWRALRLLEE 745
+ + E ++ E A+ V+ E E RAL+ LEE
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform
3 [Homo sapiens]
Length = 982
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 612 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 666
Query: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 667 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
Query: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
E V Q + L G TS R + K L G ++
Sbjct: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
Query: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 959
Query: 954 TLANNFARSFTLMLRY-NGPPP 974
L+NNFARSF MLRY NGPPP
Sbjct: 960 ALSNNFARSFHPMLRYTNGPPP 981
Score = 47.0 bits (110), Expect = 9e-05
Identities = 60/344 (17%), Positives = 131/344 (38%), Gaps = 14/344 (4%)
Query: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 53 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 110
Query: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 111 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 170
Query: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 171 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 230
Query: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 231 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 289
Query: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 290 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAE 343
EL+E+R+ +++ E ++L L + ++LE E
Sbjct: 349 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 392
Score = 46.6 bits (109), Expect = 1e-04
Identities = 94/452 (20%), Positives = 169/452 (37%), Gaps = 49/452 (10%)
Query: 93 QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKM---MVTLEPHIELQLGLKEK 149
+W+ +T R++ E+ ARD W +M + +E E + K K
Sbjct: 250 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK 309
Query: 150 QWQLSHAQVLL-HNVDNQAVLL-DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK 207
Q + ++ L HN Q + ++L+E++ L I + +DE +R E +
Sbjct: 310 QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE--LRRYCQEVFGRVER 367
Query: 208 AQKRVDLLEQVAREHE--------EYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
K++ L EH+ E A + + ++ ++ N L + Q L
Sbjct: 368 YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 427
Query: 260 STLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRK------------ 307
+ + +D P +S+ + + R+ + + E EE +
Sbjct: 428 RSERS-GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 486
Query: 308 ----VLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAA 363
+ E A + E ++ A E QI+QL L + R +Q+ +
Sbjct: 487 SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRS 543
Query: 364 KAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE----LIVFPHNLKPLSDSVIAT 419
K T EL ++ Y +S V RL+ +LKE L F NL
Sbjct: 544 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV-NLHSTETQTAGV 602
Query: 420 IQEYQSLKVK--SARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT 477
I ++ L+ + S LR ++ WQ F L + W + LE L L T
Sbjct: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL----ELST 658
Query: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
+ IE ++ +LKEL + +K +++ I
Sbjct: 659 DIQTIE---LQIKKLKELQKAVDHRKAIILSI 687
Score = 32.3 bits (72), Expect = 2.2
Identities = 24/104 (23%), Positives = 47/104 (45%), Gaps = 5/104 (4%)
Query: 632 LQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE--AHRGEAGPGDAESQEAE 689
LQ+ + ++ R + + + F + W+ +L H E D +++ +
Sbjct: 254 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC---DVQAKIKQ 310
Query: 690 FERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELREL 733
+ E ++ + AQG ++EKS P AA+++EEL EL
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDEL 354
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 72.4 bits (176), Expect = 2e-12
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 2951 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 3005
Query: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 3006 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 3059
Query: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 3060 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 3119
Query: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 3120 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 3179
Query: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
E V Q + L G TS R + K L G ++
Sbjct: 3180 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 3239
Query: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 3240 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 3298
Query: 954 TLANNFARSFTLMLRY-NGPPP 974
L+NNFARSF MLRY NGPPP
Sbjct: 3299 ALSNNFARSFHPMLRYTNGPPP 3320
Score = 60.5 bits (145), Expect = 8e-09
Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)
Query: 143 QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182
QLG K WQ +L V + LL+ LLE + N
Sbjct: 1519 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 1573
Query: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223
RIGD + ++A K + D +KAK +K V+ +EQ RE
Sbjct: 1574 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 1632
Query: 224 EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257
+ A +D + ++ LK+V++ K+N L +
Sbjct: 1633 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 1692
Query: 258 RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
++ LQ++ D + E SL+ + +++ P E +T L+E+ + L E
Sbjct: 1693 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 1749
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
E E+L+ W Q+ K + + + E L+ A D+ VA W +
Sbjct: 1750 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 1808
Query: 378 YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429
D L+ +K+ + F H L + + S + IQ Q SL
Sbjct: 1809 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 1856
Query: 430 SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478
L A A V ++ F + L+ L+ W A+ +L+ + DL ++
Sbjct: 1857 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 1916
Query: 479 LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538
+ +++ +++ S + L L + + + +E ++++ R L+ + +
Sbjct: 1917 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 1970
Query: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596
R SKLQS L QH+ F L++ ++ VQ E+ L ++ G L Q E
Sbjct: 1971 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 2024
Query: 597 -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645
+ + Q + V + K+ LS+ +Q + R +
Sbjct: 2025 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 2084
Query: 646 SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700
+++ + +LR+W+V + + G P + F+ + +F EK
Sbjct: 2085 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 2141
Query: 701 -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755
+ + VEA L++ S AA +Q EL E+ E W+ ++RL E+ L L+++W
Sbjct: 2142 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 2200
Query: 756 LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809
+ + + T S L + + + + R L+ GS +D +QL
Sbjct: 2201 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 2255
Score = 52.0 bits (123), Expect = 3e-06
Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)
Query: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266
+A+ R+ L Q A EEY ++ W++ +G + N + ++ Q +
Sbjct: 38 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 97
Query: 267 KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326
++ + LE + E+ + TS EK++ ++ E+ + E+LR + + + L+
Sbjct: 98 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 154
Query: 327 LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
+ +E ++K+L+A L + + L P + E ++H + + +L
Sbjct: 155 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 207
Query: 387 SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440
+ V Q+ L+ P ++ PL + + +E L+ ++ + AA V+
Sbjct: 208 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 263
Query: 441 LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Q+ Q QL + + + + + ++ L + + E + +E + L
Sbjct: 264 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 323
Query: 501 LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
K +L + AT LL +V G + L LL S S++
Sbjct: 324 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 375
Query: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601
LL E+G ++ A ++ Q L E L
Sbjct: 376 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 434
Query: 602 GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
A++ + QE P + D Q +L++++ ++++ E + +
Sbjct: 435 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 494
Query: 660 LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712
Q I + +E E+ PG ESQ AE + L+ E E Q SL E
Sbjct: 495 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 551
Query: 713 LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757
LV E ++ P +Q L LAE +R LLEE L + +
Sbjct: 552 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 611
Query: 758 -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813
R E D + + L P +P+ + N+L E E S+
Sbjct: 612 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 666
Query: 814 GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872
L V N L ++ + T ++ KL+ L+ + E Q L + L + +GT+
Sbjct: 667 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 718
Query: 873 DELED 877
E E+
Sbjct: 719 QEKEE 723
Score = 51.2 bits (121), Expect = 5e-06
Identities = 113/613 (18%), Positives = 226/613 (36%), Gaps = 39/613 (6%)
Query: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 2415 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 2472
Query: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 2473 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 2532
Query: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 2533 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 2592
Query: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 2593 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 2651
Query: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 2652 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 2710
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVL---QRLAQ 356
EL+E+R+ +++ E ++L L + ++LE E S L R A
Sbjct: 2711 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 2770
Query: 357 EGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSV 416
L P + L R + R AS VD + + +L+
Sbjct: 2771 SLLSPQPSSNLSLSLAQPLRSERSGRDTPAS----VDSIPLEWDHDYDLSRDLESAMSRA 2826
Query: 417 IATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLE-------VTASL 469
+ + ++ + K LR A + H Q QL KAL + + +
Sbjct: 2827 LPS-EDEEGQDDKDFYLRGAVGLS-GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKT 2884
Query: 470 PDLPSLHTFLPQIEAALMESS----RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGS 525
P P L T L E S +K L L+ +++ L G Q AG
Sbjct: 2885 PTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET---QTAGV 2941
Query: 526 MRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQ--RDLPG 583
+ +LL L ++ +++ L + + F + + L D + ++ + L+ D+
Sbjct: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
Query: 584 KQAQLSRLQGLQE 596
+ Q+ +L+ LQ+
Sbjct: 3002 IELQIKKLKELQK 3014
Score = 48.1 bits (113), Expect = 4e-05
Identities = 99/619 (15%), Positives = 243/619 (39%), Gaps = 97/619 (15%)
Query: 171 DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
+R L++ A L E Q++M + + + ++ ++Q+ +H+EY G++
Sbjct: 1116 ERALQDLADLL---------ETGQEKMAGDQKIIVSSKEE----IQQLLDKHKEYFQGLE 1162
Query: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
+ + + K+ + T+ ++ + K + LE + E + + +
Sbjct: 1163 SHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 1222
Query: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERL-------RGLLRSRGAWEQQIKQ---- 339
++++ +LE + + + L EE E+RL + L S ++ ++ Q
Sbjct: 1223 -----QELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 1276
Query: 340 -----LEAELSEFRMVLQRLAQEGLQPAAKAGTE----DELVAHWRRYSATRAALASE-E 389
+ S+ L +L + L K E + ++ HW RY + A L +
Sbjct: 1277 GKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 1336
Query: 390 PRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPL 449
DRL+ ++ + P L+ + D + A ++ + + +S+ + + + +
Sbjct: 1337 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 1396
Query: 450 QDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSR-LKELLTMLQLKKDLLIG 508
L L++ + T L ++P++ L Q++ + S + E+++ + L ++++
Sbjct: 1397 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-- 1454
Query: 509 IFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQ 568
+D D + NS+ + A E LQ+
Sbjct: 1455 -----------------QKDEDNIKNSI---------------GYKAIHEYLQKY----- 1477
Query: 569 VRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ-MEAARPLVQENPNHQHKMDQLSS 627
KG + D+ KQ + + + L + +Q +E+ R + + ++ ++
Sbjct: 1478 ------KGFKIDINCKQLTVDFVN---QSVLQISSQDVESKR---SDKTDFAEQLGAMNK 1525
Query: 628 DFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQE 687
+Q LQ + + + ++ + + + L+ W ++L+ ++
Sbjct: 1526 SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNAL 1585
Query: 688 AEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRAL----RLL 743
+ + L KE ++ +E G +++ + +++V LREL ++W L L
Sbjct: 1586 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 1645
Query: 744 EESLLSLIRNWHLQRMEVD 762
+ L S++ W ++ D
Sbjct: 1646 KILLKSVLDQWSSHKVAFD 1664
Score = 45.8 bits (107), Expect = 2e-04
Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)
Query: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61
+ F +S+E +AW+ ++ LQ D + + ++ R+ E + K + P+
Sbjct: 1879 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 1938
Query: 62 DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114
+L R+ P + K + R++++ W + T S+++ L
Sbjct: 1939 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 1988
Query: 115 ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
W E+L+ + QK+ V + + + L +++ +L A++ ++++D
Sbjct: 1989 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 2041
Query: 172 --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224
RLLE+ VD+ + +K ++ V +AQ+R +++ R+ +
Sbjct: 2042 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 2091
Query: 225 YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281
Y+ ++ + WL V LG + +P+ Q + ++ K F R + S E
Sbjct: 2092 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 2150
Query: 282 QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341
++ + + EL E+++ + EE++++L LL+ WE+ K +
Sbjct: 2151 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 2207
Query: 342 AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401
L + R ++L+Q + +EL A R A+ S + +L + LK+
Sbjct: 2208 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 2260
Query: 402 LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456
+ + ++ L++ V ++++ L ++ R + + W F ++L W
Sbjct: 2261 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 2319
Query: 457 ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515
L Q +V+ + L + + +++ E + +E LQ + L + +A
Sbjct: 2320 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 2376
Query: 516 TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574
+ +E G + DR L + + R KL+ L + L+ L + +
Sbjct: 2377 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 2433
Query: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632
K + D + +L QE D+ ++ H D ++D + ++
Sbjct: 2434 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 2493
Query: 633 QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678
Q++ +L R C S++ F W+ ++++ A +
Sbjct: 2494 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 2552
Query: 679 GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736
G A+ + +FE + E QL L+ Q + ++ + A +++ + E +
Sbjct: 2553 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 2612
Query: 737 WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768
W L+ S+L ++++ QR E ++ + +
Sbjct: 2613 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
Score = 34.7 bits (78), Expect = 0.45
Identities = 56/242 (23%), Positives = 100/242 (41%), Gaps = 42/242 (17%)
Query: 450 QDLQLWKALAQRLLEVTA----SLPDLPSLHTFLPQIEAALMESSRLKEL-LTMLQLKKD 504
Q+ QL K LA+++ ++T ++ + + L Q + L E + + EL L ++ K
Sbjct: 13 QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKV 72
Query: 505 LLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA---------------- 548
L G A+ L EQ +LH +LL+ ++ S L
Sbjct: 73 LAHGTIAWNSASQLREQY--------ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTE 124
Query: 549 ----QHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQ 604
Q + G E L++ + ++R+Q + +D+ +A+L +LQ E+
Sbjct: 125 KMSQQVAELGRETEELRQMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTS 181
Query: 605 MEAARPLVQENPNH-QH---KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLEL 660
E R ++E +H QH +M+ L QA+Q L R + V H L L
Sbjct: 182 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL--RIPEDVVASLPLCHAALRL 239
Query: 661 RQ 662
++
Sbjct: 240 QE 241
Score = 33.5 bits (75), Expect = 1.00
Identities = 57/281 (20%), Positives = 117/281 (41%), Gaps = 19/281 (6%)
Query: 334 EQQIKQLEAELSEFRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALAS 387
+Q I+Q E LS+ L + E L+ K + +++AH W S R
Sbjct: 33 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 92
Query: 388 EEPRVDRLQAQLKELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQH 444
+ ++ + EL L+ L+ SV T Q+ L ++ LR + L Q+
Sbjct: 93 HQTLLEESKEIDSELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QN 150
Query: 445 FQRPLQDLQLWKALAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELL 496
Q +D++ ++A ++L + T + P++ SL L + L E LK +
Sbjct: 151 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 210
Query: 497 TMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAA 556
+QL + L + L + L ++ +Q+ + +Q+ + Q++ +
Sbjct: 211 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 270
Query: 557 FEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
+ LQ+ + ++ + ++ QAQ+SR + L ++
Sbjct: 271 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQK 311
Score = 32.0 bits (71), Expect = 2.9
Identities = 118/640 (18%), Positives = 229/640 (35%), Gaps = 82/640 (12%)
Query: 85 ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQL 144
++L + W M+ R+E + HW+ Y + W Q LE + +
Sbjct: 1291 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 1350
Query: 145 GL-KEKQWQLSHAQVLLH---NVDNQAVLLDRLLEEAASLFN-RIGDPSVDEDAQKRMKA 199
+ +E + H L VD Q+ L +L L + D + R+ +
Sbjct: 1351 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 1410
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLW---LKAVVEK----VNGCLGRNCK 252
++ + + L Q+ + + + E W ++ V++K + +G
Sbjct: 1411 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 1470
Query: 253 LPITQRLS------TLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMR 306
Q+ + + DF +S+ + Q R+ AE +L M
Sbjct: 1471 HEYLQKYKGFKIDINCKQLTVDFV--NQSVLQISSQDVESKRSDKTDFAE----QLGAMN 1524
Query: 307 KVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAG 366
K + L+ L E+ + L GLL S +E ++ L+ L++ + G Q + +
Sbjct: 1525 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNA 1584
Query: 367 TEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSL 426
+D + ++E V++++ L + + + +S V++T++E
Sbjct: 1585 LKD--------CQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSIVMSTLRELGQT 1634
Query: 427 ------KVKSARLRNAAAVELW-----------QHFQRPLQDLQLWKALAQRLLEVTASL 469
V ++ + ++ W + L ++ L L V +
Sbjct: 1635 WANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQV 1694
Query: 470 PDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDR 529
+L +L L + E +L + + QL K+ + E T L++V +MR
Sbjct: 1695 DNLQNLQDDLEKQERSLQKFGSITN-----QLLKECHPPV--TETLTNTLKEV--NMRWN 1745
Query: 530 DLLHN--SLLQRKSKLQSLLAQHKDFG---AAFEPLQRKLLDLQVRVQAEKGLQRD---- 580
+LL LQ L L ++KD+ A+ Q + ++ K + D
Sbjct: 1746 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVAT 1805
Query: 581 --------LPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQAL 632
L G L L E G L Q++A+ Q LS AL
Sbjct: 1806 WIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-----IQSDQLSLSQHLCAL 1860
Query: 633 QRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
+++L + V ++ TF+ L L WIV + L+
Sbjct: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQ 1900
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 67.4 bits (163), Expect = 6e-11
Identities = 164/795 (20%), Positives = 317/795 (39%), Gaps = 115/795 (14%)
Query: 163 VDNQAVLLDR----LLEEAASLFNRIGDPSVDE-DAQKRMKAEYDAVKAKAQKRVDLLEQ 217
++NQ L++ L++E+ SL R+ + ++ + K ++A A+ K + + L
Sbjct: 2054 LENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA---ALVEKGEFALRL-SS 2109
Query: 218 VAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ---DIAKDFPRG-E 273
E + + G+++ ++ ++A +K +L I ++L + D KD E
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKK---------QLHIAEKLKERERENDSLKDKVENLE 2160
Query: 274 ESLETLEEQSAGVIRNT--SPLGAEKITGELEEMRKVLE----KLRALWEEEEERLRGLL 327
L+ EE VI + S E + ++EEM + L+ L L E+E + +
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 328 RSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHW-RRYSATRAALA 386
+G Q+ +L+ LS F+ +L+ Q +Q ++ T E++ + + + AAL
Sbjct: 2221 EKQG----QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALC 2276
Query: 387 SEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELW--QH 444
++ + + L I H L+ S++ ARL +L Q
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLR-------------NSIEKLRARLEADEKKQLCVLQQ 2323
Query: 445 FQRPLQDLQLWKALAQRL---LEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQL 501
+ L K + L LE+ + + +L + E +++ ++ L
Sbjct: 2324 LKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383
Query: 502 KKDLLIGIFGQERATALLEQVAGSMRDRDLLHNS---LLQRKSKLQSLLAQHKDFGAAFE 558
+ D++ +E T L++ + + +++++S +LQ K Q + + A E
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE--QEKVQMKEKSSTAME 2441
Query: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSR------------LQGLQEEGLDLGAQME 606
LQ +L +L RV A Q K+ LS LQGL E +
Sbjct: 2442 MLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
Query: 607 AARPLVQENPNHQHKMDQLSSDFQALQRSLED---LVDRCRQSVQEHCTFSHQLLELRQW 663
+ L+QE + + K+++ + L+ ++D LV + Q EH + Q LELR
Sbjct: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNL 2561
Query: 664 IVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGA 723
V QK++ + + S + E L + + E +L L + +EK + A
Sbjct: 2562 TVELEQKIQVLQSKNA-----SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTA 2616
Query: 724 --AVVQEELRELAESWRALR----------------LLEE--SLLSLIRNWHLQRMEVDS 763
+Q E+ E+A+ L+ LLEE S ++ L+ E+
Sbjct: 2617 KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKK 2676
Query: 764 GKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQW---LQVE 820
+ + + K G + I ++ R L E E H+ + LL Q+ +Q
Sbjct: 2677 SLDCMHKDQVEKEG---KVREEIAEYQLR---LHEAEKKHQ--ALLLDTNKQYEVEIQTY 2728
Query: 821 NSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLGPARGTSDELEDLRY 880
KL +S ++ KS +EL + + E L + ++++L+Y
Sbjct: 2729 REKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK--------TKMDNLKY 2780
Query: 881 QWMLYKSKLKDSGHL 895
L K + G +
Sbjct: 2781 VNQLKKENERAQGKM 2795
Score = 47.0 bits (110), Expect = 9e-05
Identities = 98/484 (20%), Positives = 190/484 (39%), Gaps = 60/484 (12%)
Query: 192 DAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEE---YQAGVDEFQLWLKAVVEKVNGCLG 248
+ +KR++AE A++AK K L Q H + +QA F W + EK L
Sbjct: 176 EERKRLEAEVKALQAK--KASQTLPQATMNHRDIARHQASSSVFS-WQQ---EKTPSHLS 229
Query: 249 RNCKLPITQRLSTLQDIAKDFPRGEE----SLETLE-----EQSAGVIRNTSPLGAEKIT 299
N +QR +D + + GE+ S TL+ S+ ++SP +++
Sbjct: 230 SN-----SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLK 284
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGL 359
+ +E+R + +L + E+ ++G + + Q+++ + EL E VL +
Sbjct: 285 AQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK------ 338
Query: 360 QPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLK-PLSDSVIA 418
DELV +Y + E ++ +L L + + L +
Sbjct: 339 -------CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKE 391
Query: 419 TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTF 478
+E+Q + R E Q R Q+LQ K + L A L L S+
Sbjct: 392 KEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVL---QAELDKLTSVKQQ 448
Query: 479 LP-QIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
L +E + R ++ Q+K++ L + ++ +LL +
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKEN------------ELRRSMEEMKKENNLLKSHSE 496
Query: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGK---QAQLSRLQGL 594
Q+ ++ L A+ K+ Q +++ + +++ + RDL K Q L+ L
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Query: 595 QEEGLDLGAQMEAARPLVQENPNH----QHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650
+ DL Q + ++ L+++ +H K+ + + +AL +LE + +E
Sbjct: 557 KLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEK 616
Query: 651 CTFS 654
FS
Sbjct: 617 TLFS 620
Score = 41.6 bits (96), Expect = 0.004
Identities = 97/471 (20%), Positives = 195/471 (41%), Gaps = 66/471 (14%)
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
+ +A KAK Q +E + E + G+DE + + VNG +
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI------------ 2507
Query: 260 STLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEE 319
++D + + +E + L+ Q + S L ++ GE + ++ +LR L E
Sbjct: 2508 QEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS--QVEGEHQLWKEQNLELRNLTVEL 2565
Query: 320 EERLRGLLRSRGA--------WEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
E++++ +L+S+ A + K LE EL +M ++ + AK E EL
Sbjct: 2566 EQKIQ-VLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK---ETEL 2621
Query: 372 VAHWRRYSATRAALASE-EPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKS 430
+ A L E +RL +L+ L+ +K D + E LK KS
Sbjct: 2622 QREMHEMAQKTAELQEELSGEKNRLAGELQLLL---EEIKSSKDQLKELTLENSELK-KS 2677
Query: 431 ARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESS 490
+ VE + + + QL A++ + L + + +I+ + +
Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALL----LDTNKQYEVEIQTYREKLT 2733
Query: 491 RLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQH 550
+E L+ +L+ DLL + E++ S++ + L +K+K+ +L
Sbjct: 2734 SKEECLSSQKLEIDLL---------KSSKEELNNSLKATTQILEEL--KKTKMDNL---- 2778
Query: 551 KDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARP 610
K + +R +++ +++ K L+ + Q +LS+LQ QE+ G M+
Sbjct: 2779 KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ-KTGTVMDT--- 2834
Query: 611 LVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCT--FSHQLLE 659
K+D+L+++ + L+ +LE+ + + ++C+ SH+ LE
Sbjct: 2835 ----------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 65.9 bits (159), Expect = 2e-10
Identities = 145/683 (21%), Positives = 268/683 (39%), Gaps = 114/683 (16%)
Query: 130 QKMMVTLEPHIELQLGLKEK-QWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPS 188
+K+ TLE + G E+ Q LS + +A L R LEE S+ +++
Sbjct: 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306
Query: 189 V-----DEDAQKRMKAEYDAVKAKA------QKRVDLLEQVAREHEEYQAGVDEFQLWLK 237
E+ +++++ E A A A + DLL + ++EE Q G E Q L
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE---QYEEEQEGKAELQRALS 1363
Query: 238 AVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPR----GEESLETLEEQSAGVIRNTSPL 293
+V + + QR L++ K + EE +E + + A + + L
Sbjct: 1364 KANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL 1422
Query: 294 GAE------------KITGELEEMRKVLEKLRALW----EEEEERLRGLLRS-------- 329
E + L++ ++ +K+ A W EE + L L+
Sbjct: 1423 QGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Query: 330 ---RGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRA--- 383
+ A+E+ + QLE E + + Q +A Q A T EL ++ +A
Sbjct: 1483 FKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Query: 384 --------ALASEEPRVDRLQAQL--------KELIVFPHNLKPLSDSVIATIQEYQSLK 427
AL EE ++ R+Q +L +++ ++ L + T++ QS
Sbjct: 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602
Query: 428 VKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALM 487
R RN A + L + + L ++++ + A R + +L L S+ L + L
Sbjct: 1603 DAEVRSRNEA-IRLKKKMEGDLNEIEIQLSHANR--QAAETLKHLRSVQGQLKDTQLHLD 1659
Query: 488 ESSR----LKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
++ R LKE L +++ + +LL + RAT LEQ + R R L LL ++
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRAT--LEQ---TERARKLAEQELLDSNERV 1714
Query: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGL---- 599
Q L Q+ + L+ L+ LQ V+ R+ K + + E L
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Query: 600 DLGAQMEAARP-LVQENPNHQHKMDQ---------------LSSDFQALQRSLEDLVDRC 643
D A +E + L Q + QH++D+ L + + L+ LE +
Sbjct: 1775 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKN 1834
Query: 644 RQSVQ---------EHCTFSHQ-----LLELRQWIVVTTQKLEAHRGEAGPGD--AESQE 687
+SV+ + T+ + +L L+ + K+++++ +A D A +
Sbjct: 1835 TESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894
Query: 688 AEFERLVAEFPEKEAQLSLVEAQ 710
+F + E E E + + E+Q
Sbjct: 1895 TKFRKAQHELEEAEERADIAESQ 1917
Score = 53.1 bits (126), Expect = 1e-06
Identities = 164/736 (22%), Positives = 302/736 (41%), Gaps = 120/736 (16%)
Query: 192 DAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNC 251
DA++R +KAK Q + E R +E +E L A K+
Sbjct: 901 DAEERCD---QLIKAKFQLEAKIKEVTERAEDE-----EEINAELTAKKRKLEDECSE-L 951
Query: 252 KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEK 311
K I TL + K+ E ++ L E+ +G+ + L EK + E ++ L+
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ-EAHQQALDD 1010
Query: 312 LRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE---FRMVLQR----------LAQEG 358
L+A EE+++ L +++ EQQ++ LE+ L + R+ L+R LAQE
Sbjct: 1011 LQA----EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Query: 359 LQPAA--KAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSV 416
+ K ++ L Y ++ + E+ + Q ++KEL L+ ++
Sbjct: 1067 ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE 1126
Query: 417 IATIQEYQ--------SLKVKSARLRNAAAVELWQ---HFQRPLQDLQLWKALAQRLLEV 465
AT + + L+ S RL A V Q + +R + L+L + L + L+
Sbjct: 1127 RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186
Query: 466 TASLPDLPSLHT-FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAG 524
A + L H + ++ + R+K+ L + + L I + ++ +E V+
Sbjct: 1187 EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI-----DDLSSSMESVSK 1241
Query: 525 SMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDL---QVRVQAEKG-LQRD 580
S + + + +L + S+ A+ K+ E +QR L +L + R+Q E G L R
Sbjct: 1242 SKANLEKICRTLEDQLSE-----ARGKN-----EEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 581 LPGKQAQLSRL----QGLQEEGLDLGAQME----AARPLVQENPNHQHKMDQLSSDFQ-- 630
L K++ +S+L Q ++ +L Q+E A L + +H D L ++
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 1351
Query: 631 -----ALQRSLEDLVDRCRQSVQEHCTFSHQLLE--------LRQWIVVTTQKLEAHRGE 677
LQR+L Q ++ T + Q E L Q + + +++EA +
Sbjct: 1352 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAK 1411
Query: 678 AG---------PGDAESQEAEFER---LVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAV 725
G+ E + ER L A +K+ V A+ E+S E A
Sbjct: 1412 CASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS 1471
Query: 726 VQEELRELAESWRALRLLEESLLSL----IRNWHLQRMEVDSGKKMVFTNNIPKSGFLIN 781
++E E ++ EE+L L N +L++ D T I ++G I+
Sbjct: 1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD------LTEQIAENGKTIH 1525
Query: 782 PMDPIPRHRRRANL--------LQEEEGS--HEDFSQLLRNFGQWLQVENSKLVRIIAMR 831
++ + R++ L L+E E + HE+ +++LR + QV+ S++ R IA +
Sbjct: 1526 ELE---KSRKQIELEKADIQLALEEAEAALEHEE-AKILRIQLELTQVK-SEIDRKIAEK 1580
Query: 832 TSTAEDLRTRKSKLQE 847
E L+ + E
Sbjct: 1581 DEEIEQLKRNYQRTVE 1596
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 63.9 bits (154), Expect = 7e-10
Identities = 191/931 (20%), Positives = 363/931 (38%), Gaps = 145/931 (15%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F+R V++ +W+K ++QL +D+ A+++A L + E + + +V + A
Sbjct: 260 FNRDVDETISWIKE-KEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA 318
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ L P I + +++ WE+ T H+R+ + +L + W
Sbjct: 319 DRLQQSHPLSATQ-IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSW 376
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL-FNRIGDP 187
+M L +A L +V LLDR E + +
Sbjct: 377 VTEMKA------------------LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFK 418
Query: 188 SVDEDAQKRMKAEY---DAVKAK----AQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVV 240
S DE Q + A + D V+ K +++R LLE ++Y+ +D QL+ +
Sbjct: 419 SADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDT- 476
Query: 241 EKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLE-TLEEQSAGVIRNTSPLGAEKIT 299
E+V+ + + + + L D + + E E +L Q EKIT
Sbjct: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQE------------EKIT 524
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE-------FRMV-- 350
E K+++ E+ R LL R A ++ + A+L++ FR
Sbjct: 525 ALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDE 584
Query: 351 LQRLAQEGLQPAAKAGTED--ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN 408
L+ E ++ A +D L +++ A A L++ + R+D L+ ++LI H
Sbjct: 585 LKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHY 644
Query: 409 LKPLSDSVIATIQEYQSL--------KVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQ 460
K D V A + E SL ++K +LR A Q F R ++D++LW +
Sbjct: 645 AK---DEVAARMNEVISLWKKLLEATELKGIKLREA---NQQQQFNRNVEDIELWLYEVE 698
Query: 461 RLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQER------ 514
L DL ++ Q + AL+E+ + +D + GI Q R
Sbjct: 699 GHLASDDYGKDLTNVQNL--QKKHALLEAD--------VAAHQDRIDGITIQARQFQDAG 748
Query: 515 ---ATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
A + ++ + + L ++ RK KL L + F + + + + +
Sbjct: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED--EETWIREKEPI 806
Query: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLD----LGAQMEAARPLVQEN----PNHQHKMD 623
A +DL G Q L + Q LQ E + A + +V+E + + K+
Sbjct: 807 AASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH 866
Query: 624 QLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG-D 682
+L+ ++AL+ S+Q F+ E W+ ++ E G G D
Sbjct: 867 ELNQKWEALKAKASQRRQDLEDSLQAQQYFA-DANEAESWM----REKEPIVGSTDYGKD 921
Query: 683 AESQEA---EFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELREL----AE 735
+S EA + E L+++ + + + Q ++ +P +E + L +
Sbjct: 922 EDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEK 981
Query: 736 SWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANL 795
S R + + + +L+L+ + + +V+ + F +P + + +DP + R NL
Sbjct: 982 SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGF---VPAA--YVKKLDP-AQSASRENL 1035
Query: 796 LQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEG 855
L EE+GS IA+R ++ + + R+ +
Sbjct: 1036 L-EEQGS-------------------------IALRQEQIDNQTRITKEAGSVSLRMKQV 1069
Query: 856 QHLFENLLRLGPARGTSDELEDLRYQWMLYK 886
+ L+ +LL LG R LE ++ML++
Sbjct: 1070 EELYHSLLELGEKR--KGMLEKSCKKFMLFR 1098
Score = 45.8 bits (107), Expect = 2e-04
Identities = 132/666 (19%), Positives = 257/666 (38%), Gaps = 146/666 (21%)
Query: 9 FDRSVEDAQAWMKAVQDQLQV--NDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
F R E+ + W +Q++LQ+ ++N + P L+ +L +K E E + +++
Sbjct: 49 FQRDAEELEKW---IQEKLQIASDENYKDP-TNLQGKL---QKHQAFEAEVQANSGAIVK 101
Query: 67 MAEA--LLACCPGDQKPGILARLKDIKAQWE-----------------ETVTYMTHCHSR 107
+ E L+ I RL ++ QWE + V Y+ C
Sbjct: 102 LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDV 161
Query: 108 IEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIE-LQLGLKEKQWQLSHAQVLLHNVDNQ 166
++W+ + E ++ +E + + H+E LQ +E Q ++ + ++ V+
Sbjct: 162 MDWI--NDKEAIVTSEELGQDLE--------HVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
Query: 167 AVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQ 226
A +L++E + + + Q + A + +K A +R L A E + +
Sbjct: 212 AA---KLIQEQHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFN 261
Query: 227 AGVDEFQLWLKAVVEKV-NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQ--- 282
VDE W+K + + + GR+ L+++Q + + E L LE++
Sbjct: 262 RDVDETISWIKEKEQLMASDDFGRD--------LASVQALLRKHEGLERDLAALEDKVKA 313
Query: 283 ---SAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQ 339
A ++ + PL A +I + EE+ E++R L E RL R
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----------- 362
Query: 340 LEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQL 399
L+ L++FR + + + ++ A DEL + +A E +DR Q
Sbjct: 363 LQRFLADFRDLTSWVTE--MKALINA---DELASD----------VAGAEALLDRHQEHK 407
Query: 400 KELIVFPHNLKPLSDS--VIATIQEYQSLKVKSARL----RNAAAVELW----------- 442
E+ + K +S + Y S +V+ AA +ELW
Sbjct: 408 GEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM 467
Query: 443 --QHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Q F R + + W + + L + L D L +EA L + ++ L+ +
Sbjct: 468 DLQLFYRDTEQVDNWMSKQEAFL-LNEDLGD------SLDSVEALLKKHEDFEKSLSAQE 520
Query: 501 LKKDLLIGIFGQERATALLEQVAGSMRD-----------RDLLHNSLLQRKSKLQSLLAQ 549
K L E AT L++ +M D R+ LH ++R+++L
Sbjct: 521 EKITAL-----DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL 575
Query: 550 HKDF--------------GAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQ 595
+ F A + + +LQ +VQ + + +L Q+++ L+
Sbjct: 576 QQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAG 635
Query: 596 EEGLDL 601
++ +D+
Sbjct: 636 QKLIDV 641
Score = 42.7 bits (99), Expect = 0.002
Identities = 131/618 (21%), Positives = 240/618 (38%), Gaps = 99/618 (16%)
Query: 287 IRNTSPLGAEKITG-ELEEMRKVLEKLRALWEE---EEERLRGLLRSRGAWEQQ----IK 338
IR P+ A G +L ++ +L+K +AL E E R++ + + A ++ +
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE 859
Query: 339 QLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAA--LASEEPRV---- 392
++A+L E + L + Q + ED L A A A + +EP V
Sbjct: 860 DVKAKLHELNQKWEALKAKASQ--RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917
Query: 393 -----DRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL----WQ 443
D +A LK+ +L S+ A ++ QS + + A + EL +
Sbjct: 918 YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYD 977
Query: 444 HFQRPLQDLQLWKALAQRLLEVTAS---LPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
+ ++ +++ + K LL T ++ F+P ++ ++ +L+
Sbjct: 978 YQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
Query: 501 LKKDLLIG---IFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQH------- 550
+ + + I Q R T V+ M+ + L++SLL+ K + +L +
Sbjct: 1038 EQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLF 1097
Query: 551 -------------------KDFGAAFEP---LQRKLLDLQVRVQAEKGLQRDLPGKQAQL 588
++ GA E LQ+K D Q ++A + +D+ K A+
Sbjct: 1098 REANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAED 1156
Query: 589 SRLQGLQEEGLDLGAQMEAARPLVQENPNHQH----KMDQLSSDFQALQRSLEDLVDRCR 644
+GL E + Q E + ++ + + K +L A S+++L +R R
Sbjct: 1157 LESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWR 1216
Query: 645 QSVQEHCTFSHQLL--------------ELRQWIVVTTQKLEAHRGEAGPGDAESQEAE- 689
S+Q+ QLL E ++WI Q L ++ + +
Sbjct: 1217 -SLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKH 1275
Query: 690 --FERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESL 747
FER +A +K SL E L+ +S PE A +QE+ EL ++W +L +
Sbjct: 1276 EGFERDLAALGDKVN--SLGETAERLI--QSHPESAEDLQEKCTELNQAWSSLGKRADQR 1331
Query: 748 LSLIRNWH-LQRMEVDSGKKMVFTNNI---PKSGFLINPMDP----IPRHRRRANLLQEE 799
+ + + H LQR D M + N I S L + + RH+ +
Sbjct: 1332 KAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDAR 1391
Query: 800 EGSHEDFSQLLRNFGQWL 817
G+ + F Q FGQ L
Sbjct: 1392 AGTFQAFEQ----FGQQL 1405
Score = 40.4 bits (93), Expect = 0.008
Identities = 139/733 (18%), Positives = 287/733 (39%), Gaps = 104/733 (14%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
++A K + L E A + +++ V++ +LWL +V G L + + L+ +Q
Sbjct: 664 LEATELKGIKLRE--ANQQQQFNRNVEDIELWLY----EVEGHLASD---DYGKDLTNVQ 714
Query: 264 DIAKDFPRGEESLETLEEQSAGV------IRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
++ K E + +++ G+ ++ AE I + E + E L+
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
+++L LR +Q + +E E + R + +A + G ++ L ++
Sbjct: 775 ARKQKLADSLRL----QQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQNLL----KK 825
Query: 378 YSATRAALASEEPRVDRLQAQLKELIVFPH-NLKPLSDSVIATIQEYQSLKVKSARLRNA 436
+ A +A +A EPR+ + + ++ H + + + Q++++LK K+++ R
Sbjct: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
Query: 437 AAVELW-QHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSR---- 491
L Q + + + W + ++ T D S L + EA + + S
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSS 945
Query: 492 ---LKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLL- 547
L+E + + G+E AL + S R+ + +K + +LL
Sbjct: 946 IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE-------VTMKKGDILTLLN 998
Query: 548 AQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDL--GAQM 605
+ +KD+ ++ D Q V A + D P + A L L+E+G Q+
Sbjct: 999 STNKDWWKV------EVNDRQGFVPAAYVKKLD-PAQSASRENL--LEEQGSIALRQEQI 1049
Query: 606 EAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCT---FSHQLLELRQ 662
+ + +E + +M Q+ + L SL +L ++ + +++ C + EL+Q
Sbjct: 1050 DNQTRITKEAGSVSLRMKQV----EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ 1105
Query: 663 WIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLV-------EAQGWLVM 715
WI L + A E + +F+ + E++L + E++G +
Sbjct: 1106 WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAE 1165
Query: 716 E---------------------KSSPEGAAVVQ-------EELRELAESWRALRLLEESL 747
E +SP +A + ++EL E WR+L+ L E
Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER 1225
Query: 748 LSLIRNWH-LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDF 806
L+ + H +QR D+ + + I + +N + +Q + HE F
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEW---IEEKNQALNT----DNYGHDLASVQALQRKHEGF 1278
Query: 807 SQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLG 866
+ L G + R+I +AEDL+ + ++L + + + G+ + +LG
Sbjct: 1279 ERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSL--GKRADQRKAKLG 1336
Query: 867 PARGTSDELEDLR 879
+ L D R
Sbjct: 1337 DSHDLQRFLSDFR 1349
Score = 38.1 bits (87), Expect = 0.040
Identities = 113/568 (19%), Positives = 225/568 (39%), Gaps = 68/568 (11%)
Query: 159 LLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQV 218
L +V LL+R E + R G E +++ A + ++++D+L+Q
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
Query: 219 AREHE----EYQAGVD---EFQLWLKAVVEKVNGCLGRNCKLPITQR---LSTLQDIAKD 268
+ E + + +D E QL+ + + N R L + L +++ + K
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
Query: 269 FPRGEESLETLEEQSAGVIRNTSPLGA--EKITGELEEMR-KVLEKLRALWEEEEERLRG 325
++++ EE+ A + L A G++ R +VL++ R L + E+
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEK--- 1543
Query: 326 LLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED--ELVAHWRRYSATRA 383
RS+ Q ++Q ++ E ++ E LQ A+ +D + + +++ A A
Sbjct: 1544 --RSKLGESQTLQQFSRDVDE----IEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEA 1597
Query: 384 ALASEEPRVDRLQAQLKELI---VFPHNLKPLSDSVIATIQEYQSLKVKSA-RLRNAAAV 439
L + R+ + LI + + + A ++Q L KSA + +
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA 1657
Query: 440 ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTML 499
Q+F ++D W + + LL DL S++ L + + + S ++ L L
Sbjct: 1658 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1717
Query: 500 QLKKDLLI--GIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAF 557
+ D L+ F + + + G + + + R++KL H+ F
Sbjct: 1718 NSQADSLMTSSAFDTSQVKDKRDTINGRFQK---IKSMAASRRAKLNESHRLHQFF---- 1770
Query: 558 EPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPN 617
R + D + ++ EK L L+ +Q L+++ L A++ A P +Q +
Sbjct: 1771 ----RDMDDEESWIK-EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLD 1825
Query: 618 HQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGE 677
K+ SD + + E++ R Q V EH EL+Q Q+LE
Sbjct: 1826 TGKKL----SDDNTIGK--EEIQQRLAQFV-EHWK------ELKQLAAARGQRLE----- 1867
Query: 678 AGPGDAESQEAEFERLVAEFPEKEAQLS 705
+ E+++ VA E+EA ++
Sbjct: 1868 --------ESLEYQQFVANVEEEEAWIN 1887
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 63.9 bits (154), Expect = 7e-10
Identities = 191/931 (20%), Positives = 363/931 (38%), Gaps = 145/931 (15%)
Query: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
F+R V++ +W+K ++QL +D+ A+++A L + E + + +V + A
Sbjct: 260 FNRDVDETISWIKE-KEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA 318
Query: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
+ L P I + +++ WE+ T H+R+ + +L + W
Sbjct: 319 DRLQQSHPLSATQ-IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSW 376
Query: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASL-FNRIGDP 187
+M L +A L +V LLDR E + +
Sbjct: 377 VTEMKA------------------LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFK 418
Query: 188 SVDEDAQKRMKAEY---DAVKAK----AQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVV 240
S DE Q + A + D V+ K +++R LLE ++Y+ +D QL+ +
Sbjct: 419 SADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDT- 476
Query: 241 EKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLE-TLEEQSAGVIRNTSPLGAEKIT 299
E+V+ + + + + L D + + E E +L Q EKIT
Sbjct: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQE------------EKIT 524
Query: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSE-------FRMV-- 350
E K+++ E+ R LL R A ++ + A+L++ FR
Sbjct: 525 ALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDE 584
Query: 351 LQRLAQEGLQPAAKAGTED--ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN 408
L+ E ++ A +D L +++ A A L++ + R+D L+ ++LI H
Sbjct: 585 LKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHY 644
Query: 409 LKPLSDSVIATIQEYQSL--------KVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQ 460
K D V A + E SL ++K +LR A Q F R ++D++LW +
Sbjct: 645 AK---DEVAARMNEVISLWKKLLEATELKGIKLREA---NQQQQFNRNVEDIELWLYEVE 698
Query: 461 RLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQER------ 514
L DL ++ Q + AL+E+ + +D + GI Q R
Sbjct: 699 GHLASDDYGKDLTNVQNL--QKKHALLEAD--------VAAHQDRIDGITIQARQFQDAG 748
Query: 515 ---ATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
A + ++ + + L ++ RK KL L + F + + + + +
Sbjct: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED--EETWIREKEPI 806
Query: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLD----LGAQMEAARPLVQEN----PNHQHKMD 623
A +DL G Q L + Q LQ E + A + +V+E + + K+
Sbjct: 807 AASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH 866
Query: 624 QLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPG-D 682
+L+ ++AL+ S+Q F+ E W+ ++ E G G D
Sbjct: 867 ELNQKWEALKAKASQRRQDLEDSLQAQQYFA-DANEAESWM----REKEPIVGSTDYGKD 921
Query: 683 AESQEA---EFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELREL----AE 735
+S EA + E L+++ + + + Q ++ +P +E + L +
Sbjct: 922 EDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEK 981
Query: 736 SWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANL 795
S R + + + +L+L+ + + +V+ + F +P + + +DP + R NL
Sbjct: 982 SPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGF---VPAA--YVKKLDP-AQSASRENL 1035
Query: 796 LQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEG 855
L EE+GS IA+R ++ + + R+ +
Sbjct: 1036 L-EEQGS-------------------------IALRQEQIDNQTRITKEAGSVSLRMKQV 1069
Query: 856 QHLFENLLRLGPARGTSDELEDLRYQWMLYK 886
+ L+ +LL LG R LE ++ML++
Sbjct: 1070 EELYHSLLELGEKR--KGMLEKSCKKFMLFR 1098
Score = 45.8 bits (107), Expect = 2e-04
Identities = 132/666 (19%), Positives = 257/666 (38%), Gaps = 146/666 (21%)
Query: 9 FDRSVEDAQAWMKAVQDQLQV--NDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
F R E+ + W +Q++LQ+ ++N + P L+ +L +K E E + +++
Sbjct: 49 FQRDAEELEKW---IQEKLQIASDENYKDP-TNLQGKL---QKHQAFEAEVQANSGAIVK 101
Query: 67 MAEA--LLACCPGDQKPGILARLKDIKAQWE-----------------ETVTYMTHCHSR 107
+ E L+ I RL ++ QWE + V Y+ C
Sbjct: 102 LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDV 161
Query: 108 IEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIE-LQLGLKEKQWQLSHAQVLLHNVDNQ 166
++W+ + E ++ +E + + H+E LQ +E Q ++ + ++ V+
Sbjct: 162 MDWI--NDKEAIVTSEELGQDLE--------HVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
Query: 167 AVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQ 226
A +L++E + + + Q + A + +K A +R L A E + +
Sbjct: 212 AA---KLIQEQHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFN 261
Query: 227 AGVDEFQLWLKAVVEKV-NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQ--- 282
VDE W+K + + + GR+ L+++Q + + E L LE++
Sbjct: 262 RDVDETISWIKEKEQLMASDDFGRD--------LASVQALLRKHEGLERDLAALEDKVKA 313
Query: 283 ---SAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQ 339
A ++ + PL A +I + EE+ E++R L E RL R
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----------- 362
Query: 340 LEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQL 399
L+ L++FR + + + ++ A DEL + +A E +DR Q
Sbjct: 363 LQRFLADFRDLTSWVTE--MKALINA---DELASD----------VAGAEALLDRHQEHK 407
Query: 400 KELIVFPHNLKPLSDS--VIATIQEYQSLKVKSARL----RNAAAVELW----------- 442
E+ + K +S + Y S +V+ AA +ELW
Sbjct: 408 GEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM 467
Query: 443 --QHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Q F R + + W + + L + L D L +EA L + ++ L+ +
Sbjct: 468 DLQLFYRDTEQVDNWMSKQEAFL-LNEDLGD------SLDSVEALLKKHEDFEKSLSAQE 520
Query: 501 LKKDLLIGIFGQERATALLEQVAGSMRD-----------RDLLHNSLLQRKSKLQSLLAQ 549
K L E AT L++ +M D R+ LH ++R+++L
Sbjct: 521 EKITAL-----DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL 575
Query: 550 HKDF--------------GAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQ 595
+ F A + + +LQ +VQ + + +L Q+++ L+
Sbjct: 576 QQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAG 635
Query: 596 EEGLDL 601
++ +D+
Sbjct: 636 QKLIDV 641
Score = 42.7 bits (99), Expect = 0.002
Identities = 131/618 (21%), Positives = 240/618 (38%), Gaps = 99/618 (16%)
Query: 287 IRNTSPLGAEKITG-ELEEMRKVLEKLRALWEE---EEERLRGLLRSRGAWEQQ----IK 338
IR P+ A G +L ++ +L+K +AL E E R++ + + A ++ +
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE 859
Query: 339 QLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAA--LASEEPRV---- 392
++A+L E + L + Q + ED L A A A + +EP V
Sbjct: 860 DVKAKLHELNQKWEALKAKASQ--RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917
Query: 393 -----DRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVEL----WQ 443
D +A LK+ +L S+ A ++ QS + + A + EL +
Sbjct: 918 YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYD 977
Query: 444 HFQRPLQDLQLWKALAQRLLEVTAS---LPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
+ ++ +++ + K LL T ++ F+P ++ ++ +L+
Sbjct: 978 YQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
Query: 501 LKKDLLIG---IFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQH------- 550
+ + + I Q R T V+ M+ + L++SLL+ K + +L +
Sbjct: 1038 EQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLF 1097
Query: 551 -------------------KDFGAAFEP---LQRKLLDLQVRVQAEKGLQRDLPGKQAQL 588
++ GA E LQ+K D Q ++A + +D+ K A+
Sbjct: 1098 REANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDI-NKVAED 1156
Query: 589 SRLQGLQEEGLDLGAQMEAARPLVQENPNHQH----KMDQLSSDFQALQRSLEDLVDRCR 644
+GL E + Q E + ++ + + K +L A S+++L +R R
Sbjct: 1157 LESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWR 1216
Query: 645 QSVQEHCTFSHQLL--------------ELRQWIVVTTQKLEAHRGEAGPGDAESQEAE- 689
S+Q+ QLL E ++WI Q L ++ + +
Sbjct: 1217 -SLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKH 1275
Query: 690 --FERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESL 747
FER +A +K SL E L+ +S PE A +QE+ EL ++W +L +
Sbjct: 1276 EGFERDLAALGDKVN--SLGETAERLI--QSHPESAEDLQEKCTELNQAWSSLGKRADQR 1331
Query: 748 LSLIRNWH-LQRMEVDSGKKMVFTNNI---PKSGFLINPMDP----IPRHRRRANLLQEE 799
+ + + H LQR D M + N I S L + + RH+ +
Sbjct: 1332 KAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDAR 1391
Query: 800 EGSHEDFSQLLRNFGQWL 817
G+ + F Q FGQ L
Sbjct: 1392 AGTFQAFEQ----FGQQL 1405
Score = 40.4 bits (93), Expect = 0.008
Identities = 139/733 (18%), Positives = 287/733 (39%), Gaps = 104/733 (14%)
Query: 204 VKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
++A K + L E A + +++ V++ +LWL +V G L + + L+ +Q
Sbjct: 664 LEATELKGIKLRE--ANQQQQFNRNVEDIELWLY----EVEGHLASD---DYGKDLTNVQ 714
Query: 264 DIAKDFPRGEESLETLEEQSAGV------IRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
++ K E + +++ G+ ++ AE I + E + E L+
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
Query: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
+++L LR +Q + +E E + R + +A + G ++ L ++
Sbjct: 775 ARKQKLADSLRL----QQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQNLL----KK 825
Query: 378 YSATRAALASEEPRVDRLQAQLKELIVFPH-NLKPLSDSVIATIQEYQSLKVKSARLRNA 436
+ A +A +A EPR+ + + ++ H + + + Q++++LK K+++ R
Sbjct: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
Query: 437 AAVELW-QHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSR---- 491
L Q + + + W + ++ T D S L + EA + + S
Sbjct: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSS 945
Query: 492 ---LKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLL- 547
L+E + + G+E AL + S R+ + +K + +LL
Sbjct: 946 IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE-------VTMKKGDILTLLN 998
Query: 548 AQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDL--GAQM 605
+ +KD+ ++ D Q V A + D P + A L L+E+G Q+
Sbjct: 999 STNKDWWKV------EVNDRQGFVPAAYVKKLD-PAQSASRENL--LEEQGSIALRQEQI 1049
Query: 606 EAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCT---FSHQLLELRQ 662
+ + +E + +M Q+ + L SL +L ++ + +++ C + EL+Q
Sbjct: 1050 DNQTRITKEAGSVSLRMKQV----EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ 1105
Query: 663 WIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLV-------EAQGWLVM 715
WI L + A E + +F+ + E++L + E++G +
Sbjct: 1106 WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAE 1165
Query: 716 E---------------------KSSPEGAAVVQ-------EELRELAESWRALRLLEESL 747
E +SP +A + ++EL E WR+L+ L E
Sbjct: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER 1225
Query: 748 LSLIRNWH-LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDF 806
L+ + H +QR D+ + + I + +N + +Q + HE F
Sbjct: 1226 SQLLGSAHEVQRFHRDADETKEW---IEEKNQALNT----DNYGHDLASVQALQRKHEGF 1278
Query: 807 SQLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLG 866
+ L G + R+I +AEDL+ + ++L + + + G+ + +LG
Sbjct: 1279 ERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSL--GKRADQRKAKLG 1336
Query: 867 PARGTSDELEDLR 879
+ L D R
Sbjct: 1337 DSHDLQRFLSDFR 1349
Score = 39.3 bits (90), Expect = 0.018
Identities = 112/569 (19%), Positives = 220/569 (38%), Gaps = 65/569 (11%)
Query: 159 LLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQV 218
L +V LL+R E + R G E +++ A + ++++D+L+Q
Sbjct: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
Query: 219 AREHE----EYQAGVD---EFQLWLKAVVEKVNGCLGRNCKLPITQR---LSTLQDIAKD 268
+ E + + +D E QL+ + + N R L + L +++ + K
Sbjct: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
Query: 269 FPRGEESLETLEEQSAGVIRNTSPLGA--EKITGELEEMR-KVLEKLRALWEEEEERLRG 325
++++ EE+ A + L A G++ R +VL++ R L + E+
Sbjct: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEK--- 1543
Query: 326 LLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAAL 385
RS+ Q ++Q ++ E + Q + K T +L ++ +A
Sbjct: 1544 --RSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFE 1601
Query: 386 ASEEPRVDRLQA------QLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSA-RLRNAAA 438
A DR++ L E + + + A ++Q L KSA + +
Sbjct: 1602 AELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE 1661
Query: 439 VELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTM 498
Q+F ++D W + + LL DL S++ L + + + S ++ L
Sbjct: 1662 ANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD 1721
Query: 499 LQLKKDLLI--GIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAA 556
L + D L+ F + + + G + + + R++KL H+ F
Sbjct: 1722 LNSQADSLMTSSAFDTSQVKDKRDTINGRFQK---IKSMAASRRAKLNESHRLHQFF--- 1775
Query: 557 FEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENP 616
R + D + ++ EK L L+ +Q L+++ L A++ A P +Q
Sbjct: 1776 -----RDMDDEESWIK-EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL 1829
Query: 617 NHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRG 676
+ K+ SD + + E++ R Q V EH EL+Q Q+LE
Sbjct: 1830 DTGKKL----SDDNTIGK--EEIQQRLAQFV-EHWK------ELKQLAAARGQRLE---- 1872
Query: 677 EAGPGDAESQEAEFERLVAEFPEKEAQLS 705
+ E+++ VA E+EA ++
Sbjct: 1873 ---------ESLEYQQFVANVEEEEAWIN 1892
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.5 bits (153), Expect = 9e-10
Identities = 116/526 (22%), Positives = 216/526 (41%), Gaps = 67/526 (12%)
Query: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQK------------- 195
K+ L A+ L ++ +A+ D+L + L + D +VD D Q+
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 196 -RMKAEYDAVKAKAQKRVDLLEQVAREHEEYQ---AGVDEFQLWLKAVVEKVNGCLGRNC 251
++ AE ++ A+ + D E ARE E A E L K E+ N +
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN----KQL 1509
Query: 252 KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE---------KITGEL 302
+ + +S+ D+ K+ E+S LE+Q + L E ++ +
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 303 EEMRKVLEK-LRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQP 361
+ M+ E+ L+ E+ EE+ R L++ Q+++LEAEL + R Q L
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIK-------QVRELEAELEDER------KQRALAV 1616
Query: 362 AAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQ 421
A+K E +L + A A ++ +LQAQ+K+ + D + A +
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 422 E----YQSLKVKSARLRN--AAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSL 475
E +SL+ + +L+ A++ +H ++ +L + +A L + L
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA--DEITNSASGKSALLDEKRRL 1734
Query: 476 HTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRD--RDLLH 533
+ Q+E L E ELL K L + E A E+ A D R L
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA---ERSAAQKSDNARQQLE 1791
Query: 534 NSLLQRKSKLQSLLAQHKD-FGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQ 592
+ K+KLQ L K F A L+ K+ Q E+ L+++ + A ++
Sbjct: 1792 RQNKELKAKLQELEGAVKSKFKATISALEAKI------GQLEEQLEQEAKERAAANKLVR 1845
Query: 593 GLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLED 638
+++ ++ Q+E R + ++ +M++ ++ + L+R LE+
Sbjct: 1846 RTEKKLKEIFMQVEDER---RHADQYKEQMEKANARMKQLKRQLEE 1888
Score = 55.5 bits (132), Expect = 2e-07
Identities = 106/482 (21%), Positives = 191/482 (39%), Gaps = 61/482 (12%)
Query: 189 VDEDAQKRMKAEYDAVKAKAQ---KRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNG 245
++E +K K + KAK + + DL +Q+A E QA +DE +L L E++ G
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA----ELQAQIDELKLQLAKKEEELQG 1094
Query: 246 CLGR--------NCKLPITQRLST-LQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAE 296
L R N L + + L + ++ +DF + S E+Q + +E
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL--------SE 1146
Query: 297 KITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRM----VLQ 352
++ E+ L+ A E +R + + + A E++ K EA++ + R L+
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE 1206
Query: 353 RLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPL 412
L+++ L+ A + + L + + LA E + +++A+ + H K L
Sbjct: 1207 ELSEQ-LEQAKRF--KANLEKNKQGLETDNKELACEVKVLQQVKAESE------HKRKKL 1257
Query: 413 SDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-D 471
A +QE + + RLR VEL + + +L L + + D
Sbjct: 1258 D----AQVQELHAKVSEGDRLR----VELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 472 LPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDL 531
SL + L + L E +R K L + + L +E +L EQ R
Sbjct: 1310 AASLESQLQDTQELLQEETRQK--LNLSSRIRQL------EEEKNSLQEQQEEEEEARKN 1361
Query: 532 LHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRL 591
L +L +S+L + D E L+ L +A L + L K +L
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA---LSQRLEEKALAYDKL 1418
Query: 592 QG----LQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSV 647
+ LQ+E DL ++ R + Q K DQL ++ +++ + DR
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 648 QE 649
+E
Sbjct: 1479 RE 1480
Score = 50.8 bits (120), Expect = 6e-06
Identities = 118/558 (21%), Positives = 216/558 (38%), Gaps = 67/558 (12%)
Query: 211 RVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFP 270
+V L QV R+ EE QA DE L +K KV G L + Q L +A+
Sbjct: 840 KVKPLLQVTRQEEELQAK-DEELLKVKEKQTKVEGEL-EEMERKHQQLLEEKNILAEQLQ 897
Query: 271 RGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSR 330
E EE A ++ + +E+ ++L L + EEEEER + L +
Sbjct: 898 AETELFAEAEEMRA------------RLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 331 GAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK-AGTEDELVAHWRRYSATRAALASEE 389
+ I+ LE +L E Q+L E + AK E+E++ + S E
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 390 PRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPL 449
R+ +QL E NL + + I + + K + R
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR--------------- 1050
Query: 450 QDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
Q+L+ K ++L T L D + QI+ ++ ++ +E L + D
Sbjct: 1051 QELEKAK---RKLDGETTDLQD--QIAELQAQIDELKLQLAKKEEELQGALARGD--DET 1103
Query: 510 FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569
+ A ++ ++ + + L K+ Q +D E L+ +L D
Sbjct: 1104 LHKNNALKVVRELQAQIAE---LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 570 RVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDF 629
A++ L+ + A+L + L+EE + AQ++ R H +++LS
Sbjct: 1161 TTAAQQELRTKREQEVAELKK--ALEEETKNHEAQIQDMR------QRHATALEELSEQL 1212
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
+ +R +L + ++ + ++ L+Q V + + + +A + ++ +E
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQ--VKAESEHKRKKLDAQVQELHAKVSE 1270
Query: 690 FERLVAEFPEKEAQL--------SLVE---------AQGWLVMEKSSPEGAAVVQEELRE 732
+RL E EK ++L +L+E A+ +E + ++QEE R+
Sbjct: 1271 GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQ 1330
Query: 733 LAESWRALRLLEESLLSL 750
+R LEE SL
Sbjct: 1331 KLNLSSRIRQLEEEKNSL 1348
Score = 44.7 bits (104), Expect = 4e-04
Identities = 104/498 (20%), Positives = 192/498 (38%), Gaps = 85/498 (17%)
Query: 499 LQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
LQ K + L+ + +E+ T +V G + + + H LL+ K+ L L + A E
Sbjct: 854 LQAKDEELLKV--KEKQT----KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 559 PLQRKLL-----------DLQVRVQAEKG----LQRDLPGKQAQLSRLQGL--QEEGLDL 601
++ +L DL+ RV+ E+ LQ + QA + L+ +EEG
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 602 GAQME--AARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Q+E A +++ ++ +S F ++ +ED + C + E + L +
Sbjct: 968 KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK 1027
Query: 660 LR--QWIVV------------TTQKLEAHRGEAGPGDAESQE------AEFERLVAEFPE 699
+R Q +++ T Q+LE + + + Q+ A+ + L + +
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Query: 700 KEAQLS--------------------------LVEAQGWLVMEKSSPEGAAVVQEELREL 733
KE +L + E Q EK+S A +++ R+L
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA---EKQKRDL 1144
Query: 734 AESWRALRL-LEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR 792
+E AL+ LE++L + L+ ++ D RH
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 793 ANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLV-RIIAMRTSTAEDLRTRK---SKLQEL 848
L E+ + F L Q L+ +N +L + ++ AE RK +++QEL
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 849 EARVPEGQHLFENLLRLGPARGTSDELEDLRYQWMLYKSK----LKDSGHLLTQSSPGEP 904
A+V EG L L A +EL+++ + K KD+ L +Q +
Sbjct: 1265 HAKVSEGDRLRVELAE--KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 905 TGFQKTRRWRGLGSLFRR 922
++TR+ L S R+
Sbjct: 1323 LLQEETRQKLNLSSRIRQ 1340
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 61.2 bits (147), Expect = 4e-09
Identities = 151/691 (21%), Positives = 270/691 (39%), Gaps = 111/691 (16%)
Query: 211 RVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFP 270
+V L QV R+ EE QA DE Q + + N L+++ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----------------ELKELEQKHS 883
Query: 271 RGEESLETLEEQSAGVIRNTSPLGAE------KITGELEEMRKVLEKLRALWEEEEERLR 324
+ E L+EQ ++ + L AE ++ + +E+ ++L ++ A EEEE+R +
Sbjct: 884 QLTEEKNLLQEQ----LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 325 GLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK-AGTEDELVAHWRRYSATRA 383
L R QQ+ LE +L E Q+L E + AK EDE++ + +
Sbjct: 940 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999
Query: 384 ALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQ 443
E R+ L L E NL L + + I E + K + R
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR--------- 1050
Query: 444 HFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALME-----SSRLKELLTM 498
Q+L+ K R LE AS H + ++A + E + + +EL
Sbjct: 1051 ------QELEKLK----RKLEGDAS-----DFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 499 LQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
L D I + A + ++ G + D L L ++ Q +D G E
Sbjct: 1096 LARLDD---EIAQKNNALKKIRELEGHISD---LQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRL--QGLQEEGLDLGAQMEAARPLVQENP 616
L+ +L D Q++L K+ Q + + L EE AQ++ R
Sbjct: 1150 ALKTELED----TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR------Q 1199
Query: 617 NHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ-EHCTFSHQLLEL---RQWIVVTTQKLE 672
H +++L+ + +R+ +L D+ +Q+++ E+ + +L L +Q + +KLE
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 673 AHRGEAGPGDAESQEAEFERLVAEFPEKEAQLS---------LVEAQGWLV--------M 715
A E +S+ ++ ER AE +K +L L EA+G + +
Sbjct: 1259 AQVQE-----LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 716 EKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPK 775
+ ++QEE R+ LR LEE SL + + ++ + T NI
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 776 SGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENS---KLVRIIAMRT 832
S D + + A+ ++ E + F + + N Q + + + KL +
Sbjct: 1374 S-------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 833 STAEDLRTRKSKLQELEARVPEGQHLFENLL 863
+DL ++L + + + Q F+ LL
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Score = 54.7 bits (130), Expect = 4e-07
Identities = 120/583 (20%), Positives = 227/583 (38%), Gaps = 70/583 (12%)
Query: 131 KMMVTLEPHIELQLGLKEK-QWQLSHAQVLLHNVDNQAVLLD----RLLEEAASLFNRIG 185
+ M+ LE +E + ++K Q + A+ + ++++ +++D +L +E L RI
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERIS 1009
Query: 186 DPSVD--------------EDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHE-------- 223
D + + ++ + M +E + K +K LE++ R+ E
Sbjct: 1010 DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 224 ---EYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLE 280
+ QA + E ++ L E++ L R I Q+ + L+ I + + E L+
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALAR-LDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 281 EQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQL 340
+ A RN + + ELE ++ LE ++E R EQ++ L
Sbjct: 1129 SERAA--RNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL-------RAKREQEVTVL 1179
Query: 341 EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDR----LQ 396
+ L E + QE Q A+A +EL ++ +A L + +++ L
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 397 AQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLR---NAAAVELWQHFQRPLQDLQ 453
+L+ L ++ + A +QE QS R R N +L + L
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297
Query: 454 LWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQE 513
+ A +L + D+ SL + L + L E +R K L + + L +E
Sbjct: 1298 EAEGKAIKLAK------DVASLSSQLQDTQELLQEETRQK--LNVSTKLRQL------EE 1343
Query: 514 RATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQA 573
+L +Q+ M + L + +L + +DF + E L+ Q ++
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE- 1402
Query: 574 EKGLQRDLPGKQAQLSRLQG----LQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDF 629
L + K A +L+ LQ+E DL ++ R LV Q K DQL ++
Sbjct: 1403 --NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLE 672
+ + D DR +E T + L + + ++LE
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503
Score = 50.4 bits (119), Expect = 8e-06
Identities = 155/750 (20%), Positives = 286/750 (38%), Gaps = 166/750 (22%)
Query: 38 AALEARLWETEKICQLEPEGRVRVDLVLRMAEALLACCPGDQKPGILARLKD---IKAQW 94
A+L ++L +T+++ Q E ++ V LR E +++ + +L + K
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLE--------EERNSLQDQLDEEMEAKQNL 1362
Query: 95 EETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIE------------- 141
E ++ + S + ++ + A +E + FQK + L E
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 142 --LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKA 199
LQ L + L + + L+ N++ + D+LL E ++ ++ D
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD------------- 1469
Query: 200 EYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
E D +A+A+++ +AR EE L K +E+ N L K + +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEE--------ALEAKEELERTNKML----KAEMEDLV 1517
Query: 260 STLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLR-ALWEE 318
S+ D+ K+ E+S LE Q +EEM+ LE+L L
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQ-------------------MEEMKTQLEELEDELQAT 1558
Query: 319 EEERLR---GLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHW 375
E+ +LR + +G +E+ ++ + + E R LQR E + EDE
Sbjct: 1559 EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE-----YETELEDE----- 1608
Query: 376 RRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQE-YQSLKVKSARLR 434
R+ A AA +L+ LK+L + +DS I +E + L+ A+++
Sbjct: 1609 RKQRALAAAAKK------KLEGDLKDLEL-------QADSAIKGREEAIKQLRKLQAQMK 1655
Query: 435 NAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKE 494
+ FQR L+D A A R +I A E+ + +
Sbjct: 1656 D---------FQRELED-----ARASR------------------DEIFATAKENEKKAK 1683
Query: 495 LLT--MLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKD 552
L ++QL++DL +++A E++A + N+L K +L++ +AQ
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ--- 1740
Query: 553 FGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLV 612
L+ +L + Q ++A R + QLS L E A + L
Sbjct: 1741 -------LEEELEEEQGNMEAMSDRVRKATQQAEQLS--NELATERSTAQKNESARQQLE 1791
Query: 613 QENPNHQHKMDQL--------SSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWI 664
++N + K+ ++ S AL+ + L ++ Q +E + L + + +
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 665 VVTTQKLEAHR--GEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEG 722
++E R E AE A ++L + E E + + A
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA------------N 1899
Query: 723 AAVVQEELRELAESWRALRLLEESLLSLIR 752
+Q EL E ES A+ +L S +R
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLR 1929
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,956,589
Number of Sequences: 37866
Number of extensions: 1573389
Number of successful extensions: 8719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 471
Number of HSP's that attempted gapping in prelim test: 6589
Number of HSP's gapped (non-prelim): 1804
length of query: 975
length of database: 18,247,518
effective HSP length: 112
effective length of query: 863
effective length of database: 14,006,526
effective search space: 12087631938
effective search space used: 12087631938
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.