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Search of human proteins with 144953895
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|144953895 nidogen 2 precursor [Homo sapiens]
(1375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|144953895 nidogen 2 precursor [Homo sapiens] 2921 0.0
gi|115298674 nidogen 1 precursor [Homo sapiens] 594 e-169
gi|119709832 low density lipoprotein receptor-related protein 5 ... 178 4e-44
gi|148727288 low density lipoprotein receptor-related protein 6 ... 176 1e-43
gi|157384998 low density lipoprotein receptor-related protein 4 ... 174 5e-43
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 156 1e-37
gi|93102379 low density lipoprotein-related protein 1B precursor... 148 3e-35
gi|118572606 hemicentin 1 [Homo sapiens] 148 4e-35
gi|61744471 low density lipoprotein receptor-related protein 8 i... 147 7e-35
gi|61744467 low density lipoprotein receptor-related protein 8 i... 147 7e-35
gi|66082554 low density lipoprotein receptor-related protein 8 i... 147 7e-35
gi|65301119 low density lipoprotein receptor-related protein 8 i... 147 7e-35
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 145 3e-34
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 133 1e-30
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 133 1e-30
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 129 2e-29
gi|32698824 low density lipoprotein receptor-related protein 5-l... 127 6e-29
gi|209447022 low density lipoprotein receptor-related protein 5-... 127 6e-29
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 126 1e-28
gi|4507157 sortilin-related receptor containing LDLR class A rep... 124 5e-28
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 120 1e-26
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 120 1e-26
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 120 1e-26
gi|56237021 fibrillin 3 precursor [Homo sapiens] 119 2e-26
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 119 2e-26
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 119 2e-26
gi|66346695 fibrillin 2 precursor [Homo sapiens] 117 8e-26
gi|194328809 latent transforming growth factor beta binding prot... 116 1e-25
gi|18497288 latent transforming growth factor beta binding prote... 116 1e-25
gi|24430141 fibrillin 1 precursor [Homo sapiens] 114 6e-25
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 2921 bits (7572), Expect = 0.0
Identities = 1375/1375 (100%), Positives = 1375/1375 (100%)
Query: 1 MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVK 60
MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVK
Sbjct: 1 MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVK 60
Query: 61 LANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRG 120
LANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRG
Sbjct: 61 LANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRG 120
Query: 121 RVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELN 180
RVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELN
Sbjct: 121 RVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELN 180
Query: 181 TFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGP 240
TFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGP
Sbjct: 181 TFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGP 240
Query: 241 YFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSF 300
YFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSF
Sbjct: 241 YFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSF 300
Query: 301 SHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESST 360
SHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESST
Sbjct: 301 SHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESST 360
Query: 361 LDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSI 420
LDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSI
Sbjct: 361 LDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSI 420
Query: 421 QPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTY 480
QPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTY
Sbjct: 421 QPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTY 480
Query: 481 NAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHL 540
NAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHL
Sbjct: 481 NAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHL 540
Query: 541 HVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPG 600
HVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPG
Sbjct: 541 HVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPG 600
Query: 601 SENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFT 660
SENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFT
Sbjct: 601 SENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFT 660
Query: 661 AHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPT 720
AHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPT
Sbjct: 661 AHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPT 720
Query: 721 TQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGT 780
TQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGT
Sbjct: 721 TQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGT 780
Query: 781 GVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRH 840
GVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRH
Sbjct: 781 GVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRH 840
Query: 841 TCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENR 900
TCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENR
Sbjct: 841 TCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENR 900
Query: 901 CHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHI 960
CHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHI
Sbjct: 901 CHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHI 960
Query: 961 PQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICE 1020
PQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICE
Sbjct: 961 PQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICE 1020
Query: 1021 RWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGT 1080
RWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGT
Sbjct: 1021 RWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGT 1080
Query: 1081 TPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLH 1140
TPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLH
Sbjct: 1081 TPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLH 1140
Query: 1141 GSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTM 1200
GSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTM
Sbjct: 1141 GSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTM 1200
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS 1320
DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS 1320
Query: 1321 IVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK 1375
IVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK
Sbjct: 1321 IVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK 1375
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 594 bits (1531), Expect = e-169
Identities = 324/821 (39%), Positives = 457/821 (55%), Gaps = 64/821 (7%)
Query: 469 DNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGA 528
D + VF+YN +++TC +N QCS HA C DYATGFCC C + + GNG+ C+ EG+
Sbjct: 371 DEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGS 430
Query: 529 PHRVNGKVSGHLHVGHT--PVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPI 586
P RVNGKV G + VG + P+ F + DLH+Y+V N GR+YTAIS IP+ +LLPL P+
Sbjct: 431 PQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPV 490
Query: 587 GGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKT 646
GG+ GW+FA+E+ G +NGFS+ G FT EVTF + I Q G+D +L+I T
Sbjct: 491 GGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDT 550
Query: 647 NIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDYSLTF-----GAINQTWSYRIH 701
++G+VP + + HI PY ELYHYS S +TS+S+R+Y++T + ++ ++Y+
Sbjct: 551 ELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWR 610
Query: 702 QNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGN 761
Q IT+Q C H P+ P+TQQL+VD VF LYN EE++LR+A++N IGPV+E S N
Sbjct: 611 QTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQN 670
Query: 762 PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINL 821
PCY G+H CDT A C PG +TCEC+ G++GDGR C D +EC+ CG +++C N
Sbjct: 671 PCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNH 730
Query: 822 PGSYRCECRSGYEFADDRHTCILITP--PANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 879
PG++RCEC GY+F+D+ TC+ + P N CE G H C +A+C++ GGS+++C+C
Sbjct: 731 PGTFRCECVEGYQFSDE-GTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSC 789
Query: 880 LPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTP 939
LPG++GDG C DVDEC +RCHP A CYNTPGSF+C+C+PGY GDGF+C+P T
Sbjct: 790 LPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEK-TR 848
Query: 940 CEQQQRH-------AQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVP 992
C+ ++ H Q P F +P+CD G++ P QCHGSTG+CWCVD DG EV
Sbjct: 849 CQHEREHILGAAGATDPQRPIPPGLF-VPECDAHGHYAPTQCHGSTGYCWCVDRDGREVE 907
Query: 993 GTQTPPGSTPP---------HCGPS------PEPTQRPPTICERWRENLLEHYGGTPRDD 1037
GT+T PG TPP H GP+ P P + + L G T R
Sbjct: 908 GTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKT 967
Query: 1038 Q-----YVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPM 1092
+ +VP +G + C K + + + G S G P I + +
Sbjct: 968 EAKAFLHVPAKVIIG--LAFDCVDKMVYWTDITEPS---IGRASLHGGEPTTI--IRQDL 1020
Query: 1093 VRPTPRPDVTPPSVGTFLLYTQG--QQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYD 1150
P + +G + +T +I L+GT+ + L++ G + D
Sbjct: 1021 GSP---EGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVT-----D 1072
Query: 1151 CRERMVYWTD--VAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLD 1208
+YWTD I + ++ G +V L P GL D + W D+ +
Sbjct: 1073 SVRGNLYWTDWNRDNPKIETSYMD-GTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTN 1131
Query: 1209 KIESA-LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDW 1248
+ E S RK L L P AV NLY+TDW
Sbjct: 1132 RAECLNPSQPSRRKAL--EGLQYP--FAVTSYGKNLYFTDW 1168
Score = 441 bits (1134), Expect = e-123
Identities = 239/559 (42%), Positives = 312/559 (55%), Gaps = 55/559 (9%)
Query: 850 NPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENR--CHPAATC 907
NPC G+H C A C + F+C C G+ GDG C D+DECSE C C
Sbjct: 670 NPCYIGTHGCDT--NAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTIC 727
Query: 908 YNTPGSFSCRCQPGY-YGDGFQCIPD--------STSSLTPCEQQQRHAQAQYA------ 952
N PG+F C C GY + D C+ + L C+ QR AQ Y
Sbjct: 728 NNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQR-AQCIYTGGSSYT 786
Query: 953 ---YPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSP 1009
PG C + P +CH FC+ PGS C P
Sbjct: 787 CSCLPGFSGDGQACQDVDECQPSRCHPDA-FCY-------------NTPGSFTCQCKPGY 832
Query: 1010 E-------PTQRPPTICERWRENLLEHYGGTPRDDQ-------YVPQCDDLGHFIPLQCH 1055
+ P + T C+ RE++L G T D Q +VP+CD GH+ P QCH
Sbjct: 833 QGDGFRCVPGEVEKTRCQHEREHILGAAGAT--DPQRPIPPGLFVPECDAHGHYAPTQCH 890
Query: 1056 GKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR-PTPRPDVTPPSVGTFLLYTQ 1114
G + +CWCVD+DGREV+GTR++PG TP C+ TVAPP+ + P V P GT LL+ Q
Sbjct: 891 GSTGYCWCVDRDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQ 950
Query: 1115 GQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELG 1174
+I LPL G ++K AK L + +I+G+ +DC ++MVYWTD+ +I RA L G
Sbjct: 951 TGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLH-G 1009
Query: 1175 AEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAI 1234
EP TI+ L SPEG+A+DH+ R ++WTDS LD+IE A LDG++R+VLF TDLVNPR I
Sbjct: 1010 GEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGI 1069
Query: 1235 AVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAG 1294
D +RGNLYWTDWNR+ PKIETS +DG NRRIL+ D+GLPNGLTFD FS LCW DAG
Sbjct: 1070 VTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAG 1129
Query: 1295 TKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLP 1354
T + EC P RR L+YPF++ SY + Y TDW+ + VV+++ + TD + P
Sbjct: 1130 TNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQP 1189
Query: 1355 EQRSHLYGITAVYPYCPTG 1373
+++ LYGIT CP G
Sbjct: 1190 HKQTRLYGITTALSQCPQG 1208
Score = 197 bits (502), Expect = 4e-50
Identities = 122/269 (45%), Positives = 157/269 (58%), Gaps = 8/269 (2%)
Query: 19 LLLPLLMLR-AAALHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYE-ARFSNLY 76
LLLPLL+ L ELFP G GD L++GDD S ++L+ L FY+ + +Y
Sbjct: 16 LLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELSGALRFYDRSDIDAVY 75
Query: 77 VGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLA 136
V TNGII+T + P + + FP F A+APFLAD+DT+ G G+V YRED SP++ A
Sbjct: 76 VTTNGIIATSEPPAKESHPGL-FPPTFGAVAPFLADLDTTDGLGKVYYREDLSPSITQRA 134
Query: 137 ARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYAL 196
A V GFP + F P+ A + TWE V Y+ R G+ NTFQAVLAS S SYA+
Sbjct: 135 AECVHRGFPEIS-FQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQAVLASSDSSSYAI 193
Query: 197 FLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDL-KSEGPYFSLTSTEQSVKNLY 255
FLYP +GLQF T K+ N Q+PA V F +G L KS G Y + +SV+NL
Sbjct: 194 FLYPEDGLQFHTTFSKKENN---QVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLA 250
Query: 256 QLSNLGIPGVWAFHIGSTSPLDNVRPAAV 284
+ SN G GVW F IGS + + V PA V
Sbjct: 251 KSSNSGQQGVWVFEIGSPATTNGVVPADV 279
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 178 bits (451), Expect = 4e-44
Identities = 95/223 (42%), Positives = 135/223 (60%), Gaps = 5/223 (2%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
+ IDYD E VYWTD R I RA L+ G+ +T+VN+ + P+G+A+D + R +YWTD
Sbjct: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLD-GSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
+ D+IE L+G+ RK+L DL PRAIA+ P+ G +YWTDW E PKIE ++LDG+
Sbjct: 435 TGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQE 493
Query: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 1323
RR+L+N +G PNGL D L W DA T K+E DGT RR ++++ L + F
Sbjct: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL 553
Query: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
D Y TDW+R + V H + + + + +Q L G+ AV
Sbjct: 554 LGDFIYWTDWQRRSIERV--HKVKASRDVIIDQLPDLMGLKAV 594
Score = 176 bits (447), Expect = 1e-43
Identities = 95/253 (37%), Positives = 146/253 (57%), Gaps = 7/253 (2%)
Query: 1103 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 1162
P + LL+ + + + G +L+ T++ +D+ + VYWTDV+
Sbjct: 28 PAAASPLLLFANRRDVRLVDAGGVKLES----TIVVSGLEDAAAVDFQFSKGAVYWTDVS 83
Query: 1163 GRTISRAGL-ELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERK 1221
I + L + GA + +V SGL+SP+GLA D + + +YWTDS ++IE A L+G+ RK
Sbjct: 84 EEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRK 143
Query: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281
VLF+ DL PRAIA+DP G +YWTDW E P+IE + +DG R+I++++DI PNGLT
Sbjct: 144 VLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
Query: 1282 DPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSIVSYADHFYHTDWRRDGVVS 1340
D + L WADA + DG+ R +V++ +L +PF++ D Y TDW+ + +
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHA 262
Query: 1341 VNKHSGQFTDEYL 1353
NK +G E L
Sbjct: 263 CNKRTGGKRKEIL 275
Score = 155 bits (391), Expect = 3e-37
Identities = 79/201 (39%), Positives = 122/201 (60%), Gaps = 3/201 (1%)
Query: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
+D+D +YWTDV+ +TISRA + G+ E +V GL PEG+A+D + + +YW D+
Sbjct: 680 LDFDVSNNHIYWTDVSLKTISRAFMN-GSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 738
Query: 1207 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1266
++IE A LDG R+VL + DL NPR++A+DP +G +YWT+W + P+I + +DG N
Sbjct: 739 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCM 797
Query: 1267 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYAD 1326
L++ +G N LT D + L W D T +E + G R VI ++L +PF + Y+D
Sbjct: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 1327 HFYHTDWRRDGVVSVNKHSGQ 1347
+ Y TDW + +K SG+
Sbjct: 857 YIYWTDWNLHSIERADKTSGR 877
Score = 105 bits (263), Expect = 2e-22
Identities = 81/272 (29%), Positives = 125/272 (45%), Gaps = 16/272 (5%)
Query: 1102 TPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTD 1160
+PP+ TFLL++Q I + + + + +L LHG + IDYD ++ +YW D
Sbjct: 942 SPPT--TFLLFSQKSAISRMIPD----DQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD 995
Query: 1161 VAGRTISRAGLELGAEPETIVNSGL-----ISPEGLAIDHIRRTMYWTDSVLDKIESALL 1215
GR + + G +P + + P L+ID RT++WT + I L
Sbjct: 996 --GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL 1053
Query: 1216 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1275
G V+ D PRAI V+ RG LY+T+ A KIE ++LDG R +L T +
Sbjct: 1054 SGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIR 1113
Query: 1276 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN-NLKYPFSIVSYADHFYHTDWR 1334
P L D L W DA K++E G R +++ N+ P + H Y D +
Sbjct: 1114 PVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQ 1173
Query: 1335 RDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
+ + V K +G + + +HL GI AV
Sbjct: 1174 QQMIERVEKTTGDKRTR-IQGRVAHLTGIHAV 1204
Score = 80.9 bits (198), Expect = 8e-15
Identities = 62/189 (32%), Positives = 85/189 (44%), Gaps = 6/189 (3%)
Query: 1128 LQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLIS 1187
L A+TL++ + GI D R +YWTD I L G + +V+ L
Sbjct: 402 LDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLN-GTSRKILVSEDLDE 460
Query: 1188 PEGLAIDHIRRTMYWTD-SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWT 1246
P +A+ + MYWTD KIE A LDG ER+VL L P +A+D G LYW
Sbjct: 461 PRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWG 520
Query: 1247 DWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGT 1306
D + KIE ++DG RR L+ LP+ F + W D + +E
Sbjct: 521 D--AKTDKIEVINVDGTKRRTLLEDK--LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA 576
Query: 1307 GRRVIQNNL 1315
R VI + L
Sbjct: 577 SRDVIIDQL 585
Score = 70.9 bits (172), Expect = 8e-12
Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 5/129 (3%)
Query: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281
VL D+ + AI DP+ G +YWTD E I + LDG + L+NT+I P+G+
Sbjct: 366 VLQVDDIRHAIAIDYDPLEGYVYWTD--DEVRAIRRAYLDGSGAQTLVNTEINDPDGIAV 423
Query: 1282 DPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIVSY--ADHFYHTDWRRDGV 1338
D ++ L W D GT ++E T +GT R++ + +L P +I + Y TDW +
Sbjct: 424 DWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPK 483
Query: 1339 VSVNKHSGQ 1347
+ GQ
Sbjct: 484 IECANLDGQ 492
Score = 32.7 bits (73), Expect = 2.5
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 5/46 (10%)
Query: 803 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPP 848
N+C +CG +C+ +PG +RC C S Y C +PP
Sbjct: 904 NDCMHNNGQCG--QLCLAIPGGHRCGCASHYTLDPSSRNC---SPP 944
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 176 bits (447), Expect = 1e-43
Identities = 91/222 (40%), Positives = 135/222 (60%), Gaps = 5/222 (2%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
+ IDYD E +YWTD R I R+ ++ G+ + +V + + P+G+A+D + R +YWTD
Sbjct: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFID-GSGSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
+ D+IE L+G+ RK+L DL PRAI +DP+ G +YWTDW E PKIE ++LDG +
Sbjct: 422 TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWG-EIPKIERAALDGSD 480
Query: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIVS 1323
R +L+NT +G PNGL D + W DA T K+E DGTGRRV +++ + + F
Sbjct: 481 RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL 540
Query: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITA 1365
D+ Y TDW+R + V+K S + E + +Q L G+ A
Sbjct: 541 LGDYVYWTDWQRRSIERVHKRSAE--REVIIDQLPDLMGLKA 580
Score = 173 bits (439), Expect = 9e-43
Identities = 89/216 (41%), Positives = 134/216 (62%), Gaps = 9/216 (4%)
Query: 1140 HGSIIVG-------IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLA 1192
+ +I+VG +D+ ++YW+DV+ I R + +V SGL+SP+GLA
Sbjct: 42 NATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLA 101
Query: 1193 IDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREA 1252
D + +YWTDS ++IE + LDGS RKVLF+ +L PRAIA+DP G +YWTDW E
Sbjct: 102 CDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWG-EV 160
Query: 1253 PKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VI 1311
PKIE + +DG +R I+IN++I PNGLT D + L WADA + + DGT R+ V+
Sbjct: 161 PKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVV 220
Query: 1312 QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
+ +L +PF++ + D Y TDW +++ NK++G+
Sbjct: 221 KGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGE 256
Score = 167 bits (424), Expect = 5e-41
Identities = 82/201 (40%), Positives = 125/201 (62%), Gaps = 3/201 (1%)
Query: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
+D+D + +YWTD++ +TISRA + G+ E +V GL PEG+A+D + + +YW D+
Sbjct: 667 LDFDVTDNRIYWTDISLKTISRAFMN-GSALEHVVEFGLDYPEGMAVDWLGKNLYWADTG 725
Query: 1207 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1266
++IE + LDG R+VL + DL +PRA+A+DP G +YWT+W + PKI+ +++DG R
Sbjct: 726 TNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK-PKIDRAAMDGSERT 784
Query: 1267 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYAD 1326
L+ ++G NGLT D + L W D T +E + G R VI ++L +PF + Y D
Sbjct: 785 TLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQD 843
Query: 1327 HFYHTDWRRDGVVSVNKHSGQ 1347
+ Y TDW R + NK SGQ
Sbjct: 844 YIYWTDWSRRSIERANKTSGQ 864
Score = 102 bits (253), Expect = 3e-21
Identities = 69/243 (28%), Positives = 121/243 (49%), Gaps = 13/243 (5%)
Query: 1108 TFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIV-GIDYDCRERMVYWTDVAGRTI 1166
TFLL++Q I + ++ ++ + +L +H V IDYD ++ +YW D I
Sbjct: 934 TFLLFSQKSAINRMVID----EQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMI 989
Query: 1167 SRAGLELGAEPETIVNSGL------ISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSER 1220
+A E G++ T+V S + I P L+ID R +YWT + I LDG
Sbjct: 990 RKAQ-EDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSV 1048
Query: 1221 KVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLT 1280
V+ + PRA+ V+P +G +Y+T+ +PKIE ++LDG R +L + + P L
Sbjct: 1049 GVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALA 1108
Query: 1281 FDPFSKLLCWADAGTKKLECTLPDGTGRRVIQ-NNLKYPFSIVSYADHFYHTDWRRDGVV 1339
D L WAD+ +++E + G R V++ +N+ P + + + Y D ++ +
Sbjct: 1109 LDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIE 1168
Query: 1340 SVN 1342
++
Sbjct: 1169 KID 1171
Score = 68.6 bits (166), Expect = 4e-11
Identities = 40/115 (34%), Positives = 61/115 (53%), Gaps = 5/115 (4%)
Query: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281
VL D+ + AI DP+ G +YWTD E I S +DG + ++ I P+G+
Sbjct: 353 VLQLEDIRHAIAIDYDPVEGYIYWTD--DEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAV 410
Query: 1282 DPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIV--SYADHFYHTDW 1333
D ++ L W D GT ++E T +GT R++ I +L+ P +IV + Y TDW
Sbjct: 411 DWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDW 465
Score = 32.3 bits (72), Expect = 3.2
Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 2/45 (4%)
Query: 800 VDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCIL 844
+ N CA C + +C+ P RC C G+E D TCI+
Sbjct: 587 IGSNPCAEENGGC--SHLCLYRPQGLRCACPIGFELISDMKTCIV 629
Score = 31.6 bits (70), Expect = 5.5
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 1146 GIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDS 1205
G+ D +R +YWTD+ I + + LG E I + P + + +YWTD
Sbjct: 795 GLTIDYAKRRLYWTDLDTNLIESSNM-LGLNREVIADD---LPHPFGLTQYQDYIYWTDW 850
Query: 1206 VLDKIESA 1213
IE A
Sbjct: 851 SRRSIERA 858
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 174 bits (441), Expect = 5e-43
Identities = 104/270 (38%), Positives = 155/270 (57%), Gaps = 6/270 (2%)
Query: 1104 PSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAG 1163
PS T+LL++ I + L+ T D + L+ ++ +DYD + VY+TDV
Sbjct: 1350 PSPETYLLFSSRGSIRRISLD-TSDHTDVHVPVPELNN--VISLDYDSVDGKVYYTDVFL 1406
Query: 1164 RTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVL 1223
I RA L G+ ET++ GL + +GLA+D + R +YWTD+ + IE++ LDGS RKVL
Sbjct: 1407 DVIRRADLN-GSNMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
Query: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
L PRAIAV P +G L+WTDW A KIE ++LDG R++LINTD+G PNGLT D
Sbjct: 1466 INNSLDEPRAIAVFPRKGYLFWTDWGHIA-KIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Query: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
++ + W DA ++E +G R+V+ +++ +PF++ Y TDW+ + V+K
Sbjct: 1525 DTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDK 1584
Query: 1344 HSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1373
+SG+ + L L I V P TG
Sbjct: 1585 YSGRNKETVLANVEG-LMDIIVVSPQRQTG 1613
Score = 173 bits (438), Expect = 1e-42
Identities = 179/615 (29%), Positives = 250/615 (40%), Gaps = 72/615 (11%)
Query: 752 KEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHR 811
+ED P C CD C G D C D R C D+ R
Sbjct: 111 EEDEFPCQNGYCIRSLWHCDGDNDC--GDNSDEQC--------DMRKCSDKE------FR 154
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
C S CI + C+ + + D C P A PC CA ++H
Sbjct: 155 CSDGS-CI--AEHWYCDGDTDCKDGSDEENCPSAVP-APPCNLEEFQCAYGRCILDIYHC 210
Query: 872 GSTFSCACLPGYAGDGHQCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQC 929
C G D C+ C E C + C N RC D
Sbjct: 211 DGDDDC----GDWSDESDCSSHQPCRSGEFMCD-SGLCINA----GWRCDGDADCDDQSD 261
Query: 930 IPDSTSSLTPCEQQQRHA----QAQYAYPGARFHIPQCDEQG--NFLPLQCHGSTGFCWC 983
+ T+S+ EQ + H+ + + G DE+ N QC CW
Sbjct: 262 ERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCW- 320
Query: 984 VDPDGHEVPGTQTPPGSTPPHCGP----SPEPTQRPPTICERWRENLLEHYGGTPRDDQY 1039
+G + + G CG SP+ RP T EN + GG + Q
Sbjct: 321 ---NGRCIGQRKLCNGVND--CGDNSDESPQQNCRPRT----GEENCNVNNGGCAQKCQM 371
Query: 1040 VP---QCD-DLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRP 1095
V QC G+ + H D C + +G QG + G T +RP
Sbjct: 372 VRGAVQCTCHTGYRLTEDGHTCQDVNECAE-EGYCSQGCTNSEGAFQCWCETGYE--LRP 428
Query: 1096 TPRP--DVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRE 1153
R + P V F +Q+ L + TLL + + +D+ R
Sbjct: 429 DRRSCKALGPEPVLLFANRIDIRQV---------LPHRSEYTLLLNNLENAIALDFHHRR 479
Query: 1154 RMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESA 1213
+V+W+DV I RA L G+ E +V++GL SP GLA+D + +YWTDS +IE A
Sbjct: 480 ELVFWSDVTLDRILRANLN-GSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVA 538
Query: 1214 LLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDI 1273
LDG+ RKVL + +L PRAIA+ P+ G +YWTDW P+IE SS+DG RRI+ +T +
Sbjct: 539 NLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWG-NTPRIEASSMDGSGRRIIADTHL 597
Query: 1274 GLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHTD 1332
PNGLT D + + W DA +E DG+ R+ VI L +PF+I + D Y TD
Sbjct: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTD 657
Query: 1333 WRRDGVVSVNKHSGQ 1347
W + S NK +G+
Sbjct: 658 WHTKSINSANKFTGK 672
Score = 172 bits (436), Expect = 2e-42
Identities = 108/291 (37%), Positives = 157/291 (53%), Gaps = 12/291 (4%)
Query: 1079 GTTPACIP-----TVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAA 1133
G T C+P T A P S+ FLL+ + I + + L D
Sbjct: 708 GCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVI 767
Query: 1134 KTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAI 1193
L + + V +D+D R+ VYWTDV+ TISRA + G E +V++ L SP GLAI
Sbjct: 768 P-LADVRSA--VALDWDSRDDHVYWTDVSTDTISRAKWD-GTGQEVVVDTSLESPAGLAI 823
Query: 1194 DHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
D + +YWTD+ D+IE A DGS R VL + +L PR I V+P+ G +YWTDW +P
Sbjct: 824 DWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWG-ASP 882
Query: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRV-IQ 1312
KIE + +D R+++I++++ PNGL D S+ L WADAG K +E DG+ R+V I
Sbjct: 883 KIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIG 942
Query: 1313 NNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGI 1363
+ L +PF + Y + Y TDW+ + S ++ +G E L E +L I
Sbjct: 943 SQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTG-LDRETLQENLENLMDI 992
Score = 164 bits (415), Expect = 5e-40
Identities = 88/243 (36%), Positives = 142/243 (58%), Gaps = 4/243 (1%)
Query: 1104 PSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAG 1163
P + +FL++ + I + L+ +++ +I +G+D +E VYW+D
Sbjct: 1045 PGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDP--QEGKVYWSDSTL 1102
Query: 1164 RTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVL 1223
ISRA L+ G++ E I+ +GL + +GLA+D I R +YWTD+ ++IE LDGS RKVL
Sbjct: 1103 HRISRANLD-GSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVL 1161
Query: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
+ +L +PRAI + G +YWTDW A K+E S +DG +R +LIN ++G PNGLT D
Sbjct: 1162 VWQNLDSPRAIVLYHEMGFMYWTDWGENA-KLERSGMDGSDRAVLINNNLGWPNGLTVDK 1220
Query: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
S L WADA T+++E +G R + + +++P+ + + Y TDW+ + +K
Sbjct: 1221 ASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADK 1280
Query: 1344 HSG 1346
+G
Sbjct: 1281 GTG 1283
Score = 70.9 bits (172), Expect = 8e-12
Identities = 59/211 (27%), Positives = 82/211 (38%), Gaps = 40/211 (18%)
Query: 749 GPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNC------VDE 802
G ++SD + PC G MCD+ + G D +C Q D RNC ++
Sbjct: 217 GDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDD--QSDERNCTTSMCTAEQ 274
Query: 803 NECATG-----FHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC--------ILITPPA 849
C +G RC C + CE + A D+ C +
Sbjct: 275 FRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGV 334
Query: 850 NPCEDGS-----HTCAP-AGQARC-VHHGG---------STFSCACLPGY--AGDGHQCT 891
N C D S C P G+ C V++GG C C GY DGH C
Sbjct: 335 NDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQ 394
Query: 892 DVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
DV+EC+E + + C N+ G+F C C+ GY
Sbjct: 395 DVNECAEEG-YCSQGCTNSEGAFQCWCETGY 424
Score = 53.1 bits (126), Expect = 2e-06
Identities = 35/112 (31%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 746 NQIGPVKEDSDPTPGNPCYD--GSHMCDTT-----ARCHPGTGVDYTCECASGYQ--GDG 796
N + ++SD +P C G C+ +C G C C +GY+ DG
Sbjct: 332 NGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGA-VQCTCHTGYRLTEDG 390
Query: 797 RNCVDENECAT-GFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITP 847
C D NECA G+ G C N G+++C C +GYE DR +C + P
Sbjct: 391 HTCQDVNECAEEGYCSQG----CTNSEGAFQCWCETGYELRPDRRSCKALGP 438
Score = 31.2 bits (69), Expect = 7.2
Identities = 12/40 (30%), Positives = 20/40 (50%), Gaps = 5/40 (12%)
Query: 808 GFHRCGPNS-----VCINLPGSYRCECRSGYEFADDRHTC 842
GF++CG + +C+ P + C C +G + D TC
Sbjct: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 156 bits (394), Expect = 1e-37
Identities = 175/645 (27%), Positives = 257/645 (39%), Gaps = 110/645 (17%)
Query: 770 CDTTARCH-PGTGVDYTCECASGYQGDGRNC--VDENECATGFHRCGPNSVCINLPGSYR 826
C+ T+ C+ P D +C G D R+C V C + C P+ CI P S+
Sbjct: 2660 CERTSLCYAPSWVCDGANDC--GDYSDERDCPGVKRPRCPLNYFAC-PSGRCI--PMSWT 2714
Query: 827 CECRSGYEFADDR----------------HTCIL---ITPPANPCEDGSHTCAPAGQARC 867
C+ E +D H CI + ++ C DGS A C
Sbjct: 2715 CDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTC 2774
Query: 868 VHHGGSTFSC----ACLPG-YAGDGHQ-CTD-VDECSENRCHPAATCYNTPGSFSCRCQP 920
G S+FSC C+P + DG + C D DE C +TC + F C+ +
Sbjct: 2775 ---GPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDR--EFMCQNR- 2828
Query: 921 GYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGF 980
QCIP C+ + A P + P C P + + G
Sbjct: 2829 -------QCIPKHFV----CDHDRDCADGSDESPECEY--PTCG------PSEFRCANGR 2869
Query: 981 C-----WCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPT-ICERWR---ENLL---E 1028
C W + DG Q+ PHC +C R E LL +
Sbjct: 2870 CLSSRQW--ECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQ 2927
Query: 1029 HYGGTPRDDQYV--------------PQCDDLGHFIPLQCHG----KSDFCWCVDKDGRE 1070
G D++ C+DL +C K D C D D
Sbjct: 2928 DDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECS 2987
Query: 1071 VQGTRSQPGTTP------ACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLN 1124
SQ C+ AP P VT FL++ + L L+
Sbjct: 2988 TTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEE--PFLIFANRYYLRKLNLD 3045
Query: 1125 GTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA--GRTISRAGLELGAEPETIVN 1182
G+ TLL + V +D+D RE+M+YWTDV G I R L G+ + +
Sbjct: 3046 GSNY------TLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-GSNVQVLHR 3098
Query: 1183 SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN 1242
+GL +P+GLA+D + +YW D D IE + L+G+ R VL + L PRA+ VD G
Sbjct: 3099 TGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGY 3158
Query: 1243 LYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTL 1302
LYWTDW + I +DG +R ++++T I PNGLT D ++ + WADA +E
Sbjct: 3159 LYWTDWG-DHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFAS 3217
Query: 1303 PDGTGRRVI-QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
DG+ R V+ ++ + F++ + D+ Y TDW + +K +G
Sbjct: 3218 LDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG 3262
Score = 146 bits (368), Expect = 2e-34
Identities = 81/210 (38%), Positives = 115/210 (54%), Gaps = 8/210 (3%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGL-ELGAEP--ETIVNSGLISPEGLAIDHIRRTMY 1201
+ +D+ + +YWTDV I R L + GA E ++ GL +PEGLA+D I +Y
Sbjct: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
Query: 1202 WTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD 1261
W +S LD+IE A LDG+ R L D+ +PRAIA+DP G L+WTDW+ P+IE +S+
Sbjct: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
Query: 1262 GENRRILINT--DIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LK 1316
G RR + G PNGLT D K + W DA + + DG+G + L
Sbjct: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
Query: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
+PF++ Y Y TDWR + + NK +G
Sbjct: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTG 1509
Score = 142 bits (358), Expect = 2e-33
Identities = 91/231 (39%), Positives = 127/231 (54%), Gaps = 11/231 (4%)
Query: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTDVAGR 1164
VG+FLLY+ + I +PL+ D + L+ + G S+ VGID+ +YW D+
Sbjct: 1889 VGSFLLYSVHEGIRGIPLD----PNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLS 1944
Query: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLF 1224
TISRA + E +V +G+ EG+A+D I +YWTD D IE A L+GS R V+
Sbjct: 1945 TISRAKRDQTWR-EDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVI 2003
Query: 1225 YTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPF 1284
L PRAI V P +G L+WT+W + P+IE S LDG R +L+N I PNG++ D
Sbjct: 2004 SQGLDKPRAITVHPEKGYLFWTEWG-QYPRIERSRLDGTERVVLVNVSISWPNGISVDYQ 2062
Query: 1285 SKLLCWADAGTKKLE-CTLPDGTGRRVI--QNNLKYPFSIVSYADHFYHTD 1332
L W DA T K+E L G R V+ NN+ FS+ + D Y +D
Sbjct: 2063 DGKLYWCDARTDKIERIDLETGENREVVLSSNNMDM-FSVSVFEDFIYWSD 2112
Score = 121 bits (304), Expect = 4e-27
Identities = 77/217 (35%), Positives = 106/217 (48%), Gaps = 18/217 (8%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPET--------------IVNSGLISPE 1189
I +D + VYWT+ TIS L A P T + SGL P
Sbjct: 3902 IDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPR 3961
Query: 1190 GLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWN 1249
G+AID + +YWTDS D IE A + G RK L + P AI VDP+RG +YW+DW
Sbjct: 3962 GIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWG 4021
Query: 1250 REAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR 1309
PKIET+++DG R L+ +I P GL D ++ L WADA + +GT
Sbjct: 4022 NH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI 4080
Query: 1310 VI---QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
V + L +PFSI + D+ Y + + V ++K
Sbjct: 4081 VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHK 4117
Score = 108 bits (269), Expect = 5e-23
Identities = 65/211 (30%), Positives = 109/211 (51%), Gaps = 12/211 (5%)
Query: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
+D+ +Y+ D I R ++ G E ETI+ G+ + EG+A+D + +YWTD
Sbjct: 564 LDFHAETGFIYFADTTSYLIGRQKID-GTERETILKDGIHNVEGVAVDWMGDNLYWTDDG 622
Query: 1207 LDK-IESALLD--GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP-----KIETS 1258
K I A L+ RK L + +PRAI VDP+ G +YWTDW + ++E +
Sbjct: 623 PKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERA 682
Query: 1259 SLDGENRRILINTDIGL-PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN--NL 1315
+DG +R I + + L PNGL+ D + L W DA ++E L +GT R+++ L
Sbjct: 683 WMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPEL 742
Query: 1316 KYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
+ F + + ++ + T++R V + + G
Sbjct: 743 NHAFGLCHHGNYLFWTEYRSGSVYRLERGVG 773
Score = 102 bits (255), Expect = 2e-21
Identities = 69/205 (33%), Positives = 104/205 (50%), Gaps = 11/205 (5%)
Query: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
FLLY + +I + L+ + T+ + + +DYD RE+ VYW+DV + I R
Sbjct: 1584 FLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTV--LDYDAREQRVYWSDVRTQAIKR 1641
Query: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT--DSVLDKIESALLDGSERKVLFYT 1226
A + G ET+V++ L + GLA+D + R ++WT D+ +I A LDGS + +
Sbjct: 1642 AFIN-GTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAV-VQ 1699
Query: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK 1286
L P + V P+RG LYWTD I +++DG NR +L + G P GL D
Sbjct: 1700 GLEQPHGLVVHPLRGKLYWTD----GDNISMANMDGSNRTLLFSGQKG-PVGLAIDFPES 1754
Query: 1287 LLCWADAGTKKLECTLPDGTGRRVI 1311
L W +G + DG+G VI
Sbjct: 1755 KLYWISSGNHTINRCNLDGSGLEVI 1779
Score = 95.1 bits (235), Expect = 4e-19
Identities = 63/180 (35%), Positives = 93/180 (51%), Gaps = 8/180 (4%)
Query: 1174 GAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGS-----ERK-VLFYTD 1227
G+ TIV + + S EGLA T+YWT I +D + ER+ V+ +
Sbjct: 2272 GSRRITIVEN-VGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSG 2330
Query: 1228 LVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKL 1287
+PRA +D + ++WT+WN + P I ++L G N LI DI PNGL D ++
Sbjct: 2331 DDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEK 2390
Query: 1288 LCWADAGTKKLECTLPDGTGRRVI-QNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
L ++DA K+E DG+ R VI ++ +PF + Y +H + TDW R V NKH G
Sbjct: 2391 LYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVG 2450
Score = 89.4 bits (220), Expect = 2e-17
Identities = 82/314 (26%), Positives = 138/314 (43%), Gaps = 32/314 (10%)
Query: 1052 LQCHGKSDFCWCVDKDGREVQGTRSQPGTTP------ACIPTVAPPMVRPTPRPDVTPPS 1105
LQ GK+ C D D V GT SQ T C+ + + P
Sbjct: 141 LQADGKT----CKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
Query: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWT---DVA 1162
LL Q I L+G ++ T+ +D+ V W D A
Sbjct: 197 RPPVLLIANSQNILATYLSGAQVS-----TITPTSTRQTTAMDFSYANETVCWVHVGDSA 251
Query: 1163 GRTISRA----GLELGAEPETI-VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDG 1217
+T + GL+ + TI ++ L E +AID + Y+ D + D+I +G
Sbjct: 252 AQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNG 311
Query: 1218 SERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPN 1277
L +L NP+ IA+DP G +++TD+ + PK+E +DG+NR L+++ I P+
Sbjct: 312 DTCVTLLDLELYNPKGIALDPAMGKVFFTDYG-QIPKVERCDMDGQNRTKLVDSKIVFPH 370
Query: 1278 GLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN--LKYPFSIVSYADHFYHTD--- 1332
G+T D S+L+ WADA +E +G GR+ I +++ + + + ++ Y T+
Sbjct: 371 GITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDN 430
Query: 1333 ---WRRDGVVSVNK 1343
++ V+ VN+
Sbjct: 431 ANAQQKTSVIRVNR 444
Score = 60.8 bits (146), Expect = 8e-09
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 22/153 (14%)
Query: 753 EDSDPTPGNP-CYDGSHMCDTTAR--CHPGTGVDYTCECAS----GYQGDGRNCVDENEC 805
+ SD P NP C H C+ +++ C G V C G D R C NEC
Sbjct: 2886 DQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC-HINEC 2944
Query: 806 ATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
+ G + C +L ++C CR G+ DD TC + D T P Q
Sbjct: 2945 LSR-KLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADV--------DECSTTFPCSQ- 2994
Query: 866 RCVHHGGSTFSCACLPGYA---GDGHQCTDVDE 895
RC++ GS + C C+ GYA GD H C V +
Sbjct: 2995 RCINTHGS-YKCLCVEGYAPRGGDPHSCKAVTD 3026
Score = 58.5 bits (140), Expect = 4e-08
Identities = 34/131 (25%), Positives = 61/131 (46%), Gaps = 3/131 (2%)
Query: 1191 LAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNR 1250
L D + +YW+D I+ A ++G+ + + DL N +AVD + NL+WT ++
Sbjct: 1620 LDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDT 1679
Query: 1251 EAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRV 1310
+I + LDG + ++ + P+GL P L W D + DG+ R +
Sbjct: 1680 NKKQINVARLDGSFKNAVVQ-GLEQPHGLVVHPLRGKLYWTDG--DNISMANMDGSNRTL 1736
Query: 1311 IQNNLKYPFSI 1321
+ + K P +
Sbjct: 1737 LFSGQKGPVGL 1747
Score = 55.8 bits (133), Expect = 3e-07
Identities = 54/198 (27%), Positives = 69/198 (34%), Gaps = 37/198 (18%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCE----------CASGYQGDGRN--CVDENECATGFH 810
C +CD C G+ CE CA+G R C EN+C
Sbjct: 2830 CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSD 2889
Query: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTCI---LITPPANPCEDGS-------HTCA 860
N C S +C + +F C+ L+ + C D S + C
Sbjct: 2890 EAPKNPHCT----SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECL 2945
Query: 861 PAGQARCVHHGGST---FSCACLPGYA--GDGHQCTDVDECSENRCHPAAT-CYNTPGSF 914
+ C F C C PG+ DG C DVDECS P + C NT GS+
Sbjct: 2946 SRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTT--FPCSQRCINTHGSY 3003
Query: 915 SCRCQPGYY---GDGFQC 929
C C GY GD C
Sbjct: 3004 KCLCVEGYAPRGGDPHSC 3021
Score = 50.8 bits (120), Expect = 9e-06
Identities = 98/399 (24%), Positives = 137/399 (34%), Gaps = 84/399 (21%)
Query: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVD----------ENECA 806
P +PC + C PG G + C C + + DGR CV ++C
Sbjct: 3290 PNHPCKVNNGGCSNLCLLSPGGG--HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCI 3347
Query: 807 TGFHRCGPNSVC----INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAP- 861
+ +C C P +CR G +F C T PA C DG + C
Sbjct: 3348 PFWWKCDTEDDCGDHSDEPPDCPEFKCRPG-QFQCSTGIC---TNPAFIC-DGDNDCQDN 3402
Query: 862 AGQARCVHHG--GSTFSCA----CLPGYAGDGHQCTDVDEC---SENRCHPAATCYNTPG 912
+ +A C H S F C C+PG +C D C + R P TC P
Sbjct: 3403 SDEANCDIHVCLPSQFKCTNTNRCIPGI----FRCNGQDNCGDGEDERDCPEVTC--APN 3456
Query: 913 SFSC----RCQPGYY--GDGFQCI-----PDSTSSLT------PCEQQQRHAQAQY---- 951
F C RC P + C+ P + + +T C+ R A++
Sbjct: 3457 QFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDG 3516
Query: 952 ---AYPGARFHIPQCDEQGNFLPLQCHGSTGFC----WCVDPDGHEVPGTQTPPGSTPPH 1004
G+ +CDE+ P Q C W D D ++ TP
Sbjct: 3517 EDDCGDGSDEPKEECDER-TCEPYQFRCKNNRCVPGRWQCDYD-NDCGDNSDEESCTPRP 3574
Query: 1005 CGPSPEPTQRPPTICERWR-------ENLLEHYGGTPRDDQYVPQCDDLGHFIPL--QCH 1055
C S I RW+ + + TPR D QC GH IPL +C
Sbjct: 3575 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKS-GHCIPLRWRCD 3633
Query: 1056 GKSDFCWCVDKDGREVQGT--RSQPGTTPACIPTVAPPM 1092
+D C+D E GT R+ P C T+ P+
Sbjct: 3634 ADAD---CMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL 3669
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/122 (27%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 1156 VYWTDVAGRT-ISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESAL 1214
++WT+ I R+ L+ G E +VN + P G+++D+ +YW D+ DKIE
Sbjct: 2022 LFWTEWGQYPRIERSRLD-GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERID 2080
Query: 1215 LD-GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDI 1273
L+ G R+V+ ++ N +V +YW+D I+ S D + + T I
Sbjct: 2081 LETGENREVVLSSN--NMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGI 2138
Query: 1274 GL 1275
G+
Sbjct: 2139 GV 2140
Score = 47.8 bits (112), Expect = 7e-05
Identities = 68/273 (24%), Positives = 91/273 (33%), Gaps = 49/273 (17%)
Query: 750 PVKEDSDPTPGN---PCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECA 806
P P PG C++G C AR P C C Y GD C + ++C
Sbjct: 4188 PTPPPDAPRPGTCNLQCFNGGS-CFLNARRQP------KCRCQPRYTGD--KC-ELDQC- 4236
Query: 807 TGFHRCGPNSVCINLP-GSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
+ C C P G C C +G+ T P + + CA +
Sbjct: 4237 --WEHCRNGGTCAASPSGMPTCRCPTGF------------TGPKCTQQVCAGYCA--NNS 4280
Query: 866 RCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATC-YNTPGSFSCRCQPGYYG 924
C + G+ C CLPG+ GD Q +CS C TC GS CRC Y
Sbjct: 4281 TCTVNQGNQPQCRCLPGFLGDRCQ---YRQCS-GYCENFGTCQMAADGSRQCRCTA--YF 4334
Query: 925 DGFQCIPDSTSSLT--PCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCW 982
+G +C + S C ++ R P C L C G
Sbjct: 4335 EGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRV-APSC--------LTCVGHCSNGG 4385
Query: 983 CVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRP 1015
+ +P Q PP T P C Q+P
Sbjct: 4386 SCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQP 4418
Score = 45.4 bits (106), Expect = 4e-04
Identities = 46/151 (30%), Positives = 61/151 (40%), Gaps = 23/151 (15%)
Query: 785 TCECASGYQGDG-RNCVDENECATGF------HRCGPNSVCINLPGSYRCECRSGYEFAD 837
TC + G++ DG R+C D ++ A RC PN N G+ C S +
Sbjct: 39 TC-ISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEH--NCLGTELCVPMS--RLCN 93
Query: 838 DRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTF---SCACLPGYA--GDGHQCTD 892
C+ + C + C+ G C HH T +C C + DG C D
Sbjct: 94 GVQDCMDGSDEGPHCRELQGNCSRLG---CQHHCVPTLDGPTCYCNSSFQLQADGKTCKD 150
Query: 893 VDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
DECS C + C NT GSF C C GY
Sbjct: 151 FDECSVYGTC--SQLCTNTDGSFICGCVEGY 179
Score = 44.3 bits (103), Expect = 8e-04
Identities = 22/60 (36%), Positives = 31/60 (51%), Gaps = 5/60 (8%)
Query: 785 TCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
TC C S +Q DG+ C D +EC+ + C + +C N GS+ C C GY D +C
Sbjct: 132 TCYCNSSFQLQADGKTCKDFDECSV-YGTC--SQLCTNTDGSFICGCVEGYLLQPDNRSC 188
Score = 40.8 bits (94), Expect = 0.009
Identities = 52/215 (24%), Positives = 73/215 (33%), Gaps = 43/215 (20%)
Query: 753 EDSDPTPGNPCYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENECATGFHR 811
ED P C C T RC P V D +C G + NC + C R
Sbjct: 3443 EDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDG-SDEPANCT-QMTCGVDEFR 3500
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
C + CI P ++C+ D P C++ TC P Q RC ++
Sbjct: 3501 CKDSGRCI--PARWKCDGEDDCGDGSDE--------PKEECDE--RTCEPY-QFRCKNN- 3546
Query: 872 GSTFSCACLPG-----YAGDGHQCTDVDECSENRCHPAATCYNTPGSFSC---RCQPGYY 923
C+PG Y D +D + C+ C + FSC RC G +
Sbjct: 3547 ------RCVPGRWQCDYDNDCGDNSDEESCTPRPC--------SESEFSCANGRCIAGRW 3592
Query: 924 ---GDGFQCIPDSTSSLTP-CEQQQRHAQAQYAYP 954
GD TP C+ Q ++ + P
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIP 3627
Score = 38.9 bits (89), Expect = 0.034
Identities = 47/214 (21%), Positives = 72/214 (33%), Gaps = 53/214 (24%)
Query: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVC 818
P C+ C C P + + C+ + D + DE C H C P SV
Sbjct: 1058 PPGGCHTDEFQCRLDGLCIP---LRWRCDGDT----DCMDSSDEKSCEGVTHVCDP-SVK 1109
Query: 819 INLPGSYRCECRSGY-------EFADDRHTC--ILITPPANPCEDGSHTCAPA-----GQ 864
S RC ++ E D C + PP++PC + + C P G
Sbjct: 1110 FGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGN 1169
Query: 865 ARC--------------VHHGGSTFSCACLPG------------YAGDGHQCTDVDECSE 898
C +++GG + +C+ PG D H C C++
Sbjct: 1170 DDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAK 1229
Query: 899 N-RCHPAATCYNTPGSFSCRCQPGYY--GDGFQC 929
+ +C + C S C C G+ DG C
Sbjct: 1230 HLKC--SQKCDQNKFSVKCSCYEGWVLEPDGESC 1261
Score = 37.0 bits (84), Expect = 0.13
Identities = 34/123 (27%), Positives = 49/123 (39%), Gaps = 29/123 (23%)
Query: 801 DENECATGFHRC-----GPNSVCINLPGSYRCECRSGYEFADDRHTCI----LITPPANP 851
D + G ++C G +S+C+ PGS +C C D TC+ + PP
Sbjct: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPP--Q 853
Query: 852 CEDGSHTCAPAGQARCVHHGGSTFSC----ACL------PGYAGDGHQC-TDVDECSENR 900
C+ G CA +RC+ + C CL P H C +D +C NR
Sbjct: 854 CQPGEFACA---NSRCIQ---ERWKCDGDNDCLDNSDEAPALCHQ-HTCPSDRFKCENNR 906
Query: 901 CHP 903
C P
Sbjct: 907 CIP 909
Score = 34.7 bits (78), Expect = 0.65
Identities = 35/139 (25%), Positives = 53/139 (38%), Gaps = 24/139 (17%)
Query: 759 PGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVC 818
P +PC + + +C P D +C G +G C ++C+ C N C
Sbjct: 1148 PSHPCANNTSVC-----LPPDKLCDGNDDCGDG-SDEGELC---DQCSLNNGGCSHN--C 1196
Query: 819 INLPGS-YRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSC 877
PG C C G E D HTC + + A + C+ +C + S C
Sbjct: 1197 SVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK-----CS----QKCDQNKFSV-KC 1246
Query: 878 ACLPGYA--GDGHQCTDVD 894
+C G+ DG C +D
Sbjct: 1247 SCYEGWVLEPDGESCRSLD 1265
Score = 33.9 bits (76), Expect = 1.1
Identities = 39/166 (23%), Positives = 58/166 (34%), Gaps = 37/166 (22%)
Query: 749 GPVKEDSDPTPGNP--CYDGSHMCDTTARCHPGT-GVDYTCECASGYQGDGRNCVDE--- 802
G +ED +P + C D RC + + +C G D +C +
Sbjct: 3725 GTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDG--SDEEDCSIDPKL 3782
Query: 803 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP-CEDGSHTCAP 861
CAT CG + C+ + C CRSG+ T P P C+D +
Sbjct: 3783 TSCATNASICGDEARCVRTEKAAYCACRSGFH-----------TVPGQPGCQDIN----- 3826
Query: 862 AGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATC 907
C+ G +C+ L GH C+ C+ N TC
Sbjct: 3827 ----ECLRFG----TCSQLCNNTKGGHLCS----CARNFMKTHNTC 3860
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 148 bits (374), Expect = 3e-35
Identities = 84/211 (39%), Positives = 118/211 (55%), Gaps = 8/211 (3%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGL-ELGAEP--ETIVNSGLISPEGLAIDHIRRTMY 1201
+ +D+ + ++YWTDV I R L E G E +V GL +PEGL +D I +Y
Sbjct: 1291 IALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIY 1350
Query: 1202 WTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLD 1261
W DS LD+IE A LDGS R L + +PRAIA+DP G L+WTDW+ P+IE++S+
Sbjct: 1351 WIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMS 1410
Query: 1262 GENRRILIN--TDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNN--LK 1316
G R+ + PNGLT D F K + W DA + + L DGT +I+ + L
Sbjct: 1411 GAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLS 1470
Query: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
+PF++ Y Y TDWR + + NK +GQ
Sbjct: 1471 HPFAVSLYGSEVYWTDWRTNTLSKANKWTGQ 1501
Score = 125 bits (313), Expect = 4e-28
Identities = 80/230 (34%), Positives = 122/230 (53%), Gaps = 9/230 (3%)
Query: 1106 VGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTDVAGR 1164
+ +FL+Y+ + I +PL + D L+ + G S VGID+ +YWTD+
Sbjct: 1877 IESFLMYSVHEGIRGIPLEPS----DKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFN 1932
Query: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLF 1224
ISRA + + E I+ +GL EG+A+D I +YWTD + IE A L+GS R V+
Sbjct: 1933 KISRAKRDQTWK-EDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVII 1991
Query: 1225 YTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPF 1284
L PR+IAV P +G L+WT+W + P I + LDG + +L++ I PNG++ D
Sbjct: 1992 SQGLDQPRSIAVHPEKGLLFWTEWG-QMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYE 2050
Query: 1285 SKLLCWADAGTKKLE-CTLPDGTGRRVIQNNLKYP-FSIVSYADHFYHTD 1332
L W DA T K+E L G R ++ + FS+ + + Y +D
Sbjct: 2051 ENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSD 2100
Score = 116 bits (291), Expect = 1e-25
Identities = 70/232 (30%), Positives = 117/232 (50%), Gaps = 13/232 (5%)
Query: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT-DS 1205
+D+ +Y+ D I R ++ G E ETI+ L + EG+A+D I +YWT D
Sbjct: 561 LDFHAETNYIYFADTTSFLIGRQKID-GTERETILKDDLDNVEGIAVDWIGNNLYWTNDG 619
Query: 1206 VLDKIESALLD--GSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNRE-----APKIETS 1258
I A L+ RK L ++ +PR I VDP+ G +YWTDW + +IE +
Sbjct: 620 HRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKA 679
Query: 1259 SLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN--NLK 1316
+DG NR+I + + + PNGLT D + L W DA +E +GT R+++ + L
Sbjct: 680 WMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELN 739
Query: 1317 YPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYP 1368
+PF + + ++ + TD+ + ++ + + T L +R L+G+ P
Sbjct: 740 HPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVT--LLRHERPPLFGLQIYDP 789
Score = 108 bits (269), Expect = 5e-23
Identities = 157/643 (24%), Positives = 251/643 (39%), Gaps = 94/643 (14%)
Query: 733 YNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY 792
Y+DE L+ V N+ +E+ P C + +CD C G ++ C+ + +
Sbjct: 2668 YSDE---LKCPVQNK-HKCEENYFSCPSGRCILNTWICDGQKDCEDGRD-EFHCDSSCSW 2722
Query: 793 QG---DGRNCVDENECATGFHRCGP-----NSVCINLPGSYRCECRSGYEFADDRHTCIL 844
+ C+ ++ G CG +S+C + + G RH
Sbjct: 2723 NQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHW--- 2779
Query: 845 ITPPANPCEDGSHTCAPAGQARCVHHGGSTFSC---ACLPGYAGDGHQCTDVDECSENRC 901
+ C DGS + AG A + F C C+P C D+C +
Sbjct: 2780 LCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQ----FVCDHDDDCGDGSD 2835
Query: 902 HPAATCYNTPGS--FSC---RC--QPGYYGDG-FQCIPDSTSS--LTP-CEQQQRHAQAQ 950
Y G+ FSC RC + DG F C PD + L P C+ ++ +
Sbjct: 2836 ESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDC-PDHSDEAPLNPKCKSAEQSCNSS 2894
Query: 951 YAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDP--DGHEVPGTQTPPGSTPPHCGPS 1008
+ C + G +P S G C D DG + + G S
Sbjct: 2895 FF---------MC-KNGRCIP-----SGGLCDNKDDCGDGSDERNCHINECLSKKVSGCS 2939
Query: 1009 PEPTQRPPTI-CERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKD 1067
+ P + C+ W L+ G T D + +C G QC C+ D
Sbjct: 2940 QDCQDLPVSYKCKCWPGFQLKDDGKTCVD---IDECSS-GFPCSQQCINTYGTYKCLCTD 2995
Query: 1068 GREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTR 1127
G E+Q P C D P FL+ +I + +G+
Sbjct: 2996 GYEIQ-----PDNPNGC-----------KSLSDEEP-----FLILADHHEIRKISTDGSN 3034
Query: 1128 LQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA---GRTISRAGLELGAEPETIVNSG 1184
TLL + ++ ID+D RE +YW D + G I+R L G++ + + N+
Sbjct: 3035 Y------TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLN-GSDIKVVHNTA 3087
Query: 1185 LISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLY 1244
+ P LA+D I + +YW+D+ IE + L+G +L L PR +++DP G LY
Sbjct: 3088 V--PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLY 3145
Query: 1245 WTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPD 1304
W D E P I +DG N+ ++I T I P LT D ++ L WAD +E + D
Sbjct: 3146 WIDC-CEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMD 3202
Query: 1305 GTGRRVIQN-NLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
G+ R + N ++ ++ + D+ Y TD + + +K SG
Sbjct: 3203 GSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSG 3245
Score = 99.8 bits (247), Expect = 2e-20
Identities = 66/207 (31%), Positives = 103/207 (49%), Gaps = 11/207 (5%)
Query: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
FLLY + +I + ++ A T+ + + ID+D E +YWTD+ +TI R
Sbjct: 1575 FLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTV--IDFDASEERLYWTDIKTQTIKR 1632
Query: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLD--KIESALLDGSERKVLFYT 1226
A + G ET+++ + S GLA+D + R +YW S D +I A LDGS + + +
Sbjct: 1633 AFIN-GTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIH- 1690
Query: 1227 DLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK 1286
+ P+ +A P+RG LYWTD N I +++DG N +IL P GL+ D
Sbjct: 1691 GIDKPQCLAAHPVRGKLYWTDGN----TINMANMDGSNSKILFQNQ-KEPVGLSIDYVEN 1745
Query: 1287 LLCWADAGTKKLECTLPDGTGRRVIQN 1313
L W +G + DG VI++
Sbjct: 1746 KLYWISSGNGTINRCNLDGGNLEVIES 1772
Score = 98.2 bits (243), Expect = 5e-20
Identities = 85/301 (28%), Positives = 138/301 (45%), Gaps = 26/301 (8%)
Query: 1063 CVDKDGREVQGTRSQP------GTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQ 1116
C D+D V GT SQ T +C+ + + + P LL +
Sbjct: 153 CKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFE 212
Query: 1117 QIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRT-------ISRA 1169
I LNG+++ TL S++G+ I +D+ E M+ W + + I++A
Sbjct: 213 TIEVFYLNGSKMA-----TLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKA 267
Query: 1170 GLELGAEPETIVN--SGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTD 1227
G G E +N + + +AID + R +Y+ D V D+I +GS L +
Sbjct: 268 G---GLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE 324
Query: 1228 LVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKL 1287
L NP+AIAVDPI G L++TD+ A K+E +DG NR +I++ P L D +KL
Sbjct: 325 LHNPKAIAVDPIAGKLFFTDYGNVA-KVERCDMDGMNRTRIIDSKTEQPAALALDLVNKL 383
Query: 1288 LCWADAGTKKLECTLPDGTGRR-VIQ-NNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHS 1345
+ W D + G R VIQ +++ + I + D+ Y T+ +V +N+ +
Sbjct: 384 VYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFN 443
Query: 1346 G 1346
G
Sbjct: 444 G 444
Score = 95.9 bits (237), Expect = 2e-19
Identities = 59/198 (29%), Positives = 100/198 (50%), Gaps = 7/198 (3%)
Query: 1176 EPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSE------RKVLFYTDLV 1229
E ++ + S EGLA T+YWT S I +D + V+ ++
Sbjct: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
Query: 1230 NPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLC 1289
+P +A+D + ++WT+WN + P I S+L G+N +++++TDI PNGLT D ++ L
Sbjct: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
Query: 1290 WADAGTKKLECTLPDGTGRRVIQNNLKYPF-SIVSYADHFYHTDWRRDGVVSVNKHSGQF 1348
++D K+E DG+ R VI + F S+ Y ++ + +DW R ++ NK++G
Sbjct: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGD 2438
Query: 1349 TDEYLPEQRSHLYGITAV 1366
T + GI AV
Sbjct: 2439 TKILRSDIPHQPMGIIAV 2456
Score = 79.3 bits (194), Expect = 2e-14
Identities = 73/256 (28%), Positives = 109/256 (42%), Gaps = 33/256 (12%)
Query: 1140 HGSIIVGIDYDCRERMVYWTDVAGRTISRAGL---ELGAEPETIVNSGLISPE-----GL 1191
H S I G+D + M+ W+ + G+ + + NSGLI PE +
Sbjct: 3919 HNSRITGMDVYYQRDMIIWST----QFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDI 3974
Query: 1192 AIDHIRRTMYWTD---------------SVLDKIESALLDGSERKVLFYTDLVNPRAIAV 1236
A+D + +YWTD S+ I L+G L P AIAV
Sbjct: 3975 AVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAV 4034
Query: 1237 DPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTK 1296
+P RG +YWT + IE +++DG RRIL+ ++ P GL D FS+ + WAD
Sbjct: 4035 NPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELS 4093
Query: 1297 KLECTLPDGTGRRV---IQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYL 1353
+ L DG+ V + L +P I + D+ Y ++GV V K G + EYL
Sbjct: 4094 IIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKF-GHGSVEYL 4151
Query: 1354 PEQRSHLYGITAVYPY 1369
G+ + Y
Sbjct: 4152 ALNIDKTKGVLISHRY 4167
Score = 59.3 bits (142), Expect = 2e-08
Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 6/151 (3%)
Query: 1194 DHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
D +YWTD I+ A ++G+ + + D+ + R +AVD + NLYW +
Sbjct: 1614 DASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDET 1673
Query: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN 1313
+I + LDG + +I+ I P L P L W D T + DG+ +++
Sbjct: 1674 QINVARLDGSLKTSIIH-GIDKPQCLAAHPVRGKLYWTDGNT--INMANMDGSNSKILFQ 1730
Query: 1314 NLKYPFSI-VSYADHFYHTDWRRDGVVSVNK 1343
N K P + + Y ++ + W G ++N+
Sbjct: 1731 NQKEPVGLSIDYVENKLY--WISSGNGTINR 1759
Score = 56.2 bits (134), Expect = 2e-07
Identities = 45/138 (32%), Positives = 70/138 (50%), Gaps = 17/138 (12%)
Query: 1123 LNGTRLQK--DAAKTLLSLHGSIIVGIDYDCRERMVYWTD--------VAGRTISRAGLE 1172
+N RL+K + KTLL S GI D +YWTD GR I +A ++
Sbjct: 624 INVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGR-IEKAWMD 682
Query: 1173 LGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFY-TDLVNP 1231
G + V S ++ P GL +D T+YW D+ D IE L+G+ RK+++ +L +P
Sbjct: 683 -GFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHP 741
Query: 1232 RAIAVDPIRGN-LYWTDW 1248
++ GN ++WTD+
Sbjct: 742 FGLS---HHGNYVFWTDY 756
Score = 52.8 bits (125), Expect = 2e-06
Identities = 33/118 (27%), Positives = 65/118 (55%), Gaps = 6/118 (5%)
Query: 1153 ERMVYWTDVAGR--TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKI 1210
+ +++WT+ + +I R+ L G + +V++ +++P GL ID+ +Y++D L KI
Sbjct: 2329 QNLMFWTNWNEQHPSIMRSTLT-GKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKI 2387
Query: 1211 ESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRIL 1268
E DGS+R V+ + ++AV ++W+DW R A + ++ G + +IL
Sbjct: 2388 ERCEYDGSQRHVIVKSGPGTFLSLAV--YDNYIFWSDWGRRA-ILRSNKYTGGDTKIL 2442
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/198 (23%), Positives = 67/198 (33%), Gaps = 34/198 (17%)
Query: 765 DGSHMCDTTARCHPGTGVDYTCECASGYQ-GDGRNCVDENECATGFHRCGPNS------- 816
DG C + P V + C ++ + R C+ + G CG NS
Sbjct: 3694 DGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGG 3753
Query: 817 --------------VCIN---LPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTC 859
C N +P +C+ D C I P CED + C
Sbjct: 3754 KLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC-RIAPTEYTCEDNVNPC 3812
Query: 860 APAGQARCVHHGGSTFSCACLPGYAGD--GHQCTDVDECSE-NRCHPAATCYNTPGSFSC 916
A C S F C C PG+ + QC D++EC C + C N GS+ C
Sbjct: 3813 GD--DAYCNQIKTSVF-CRCKPGFQRNMKNRQCEDLNECLVFGTC--SHQCINVEGSYKC 3867
Query: 917 RCQPGYYGDGFQCIPDST 934
C + CI + +
Sbjct: 3868 VCDQNFQERNNTCIAEGS 3885
Score = 47.8 bits (112), Expect = 7e-05
Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 786 CECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
C C G++ DGR+C D++ECA + C + C N GSY C C GY D +C
Sbjct: 138 CYCEDGFEITEDGRSCKDQDECAV-YGTC--SQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/83 (34%), Positives = 38/83 (45%), Gaps = 8/83 (9%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN--CVDENECATGFHRCGPNSVCIN 820
C D + C A C+ C C G+Q + +N C D NEC F C CIN
Sbjct: 3805 CEDNVNPCGDDAYCNQ-IKTSVFCRCKPGFQRNMKNRQCEDLNECLV-FGTCSHQ--CIN 3860
Query: 821 LPGSYRCECRSGYEFADDRHTCI 843
+ GSY+C C F + +TCI
Sbjct: 3861 VEGSYKCVC--DQNFQERNNTCI 3881
Score = 44.3 bits (103), Expect = 8e-04
Identities = 46/171 (26%), Positives = 65/171 (38%), Gaps = 29/171 (16%)
Query: 763 CYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENE--CATGFHRCGPNSVCI 819
C G +C C + + D +C C +E E C C + C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 820 NLPGSYRC----ECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG-QARCVHHGGST 874
+L S C +C GY+ + H C++ C Q +C ST
Sbjct: 92 HL--SQLCNGVLDCPDGYD--EGVH-----------CQELLSNCQQLNCQYKCTMVRNST 136
Query: 875 FSCACLPGY--AGDGHQCTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
C C G+ DG C D DEC+ C + TC NT GS++C C GY
Sbjct: 137 -RCYCEDGFEITEDGRSCKDQDECAVYGTC--SQTCRNTHGSYTCSCVEGY 184
Score = 40.8 bits (94), Expect = 0.009
Identities = 46/184 (25%), Positives = 69/184 (37%), Gaps = 21/184 (11%)
Query: 817 VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFS 876
+C+ P C C G + TC + + C+ TC G RC+ +
Sbjct: 4184 LCLLNPSGATCVCPEGKYLING--TCNDDSLLDDSCK---LTCENGG--RCILNEKGDLR 4236
Query: 877 CACLPGYAGDGHQCTDVDECSENRCHPAATCY-NTPGSFSCRCQPGYYGDGFQ------- 928
C C P Y+G+ +C +V+ CS N C TC + G +C C G+ G
Sbjct: 4237 CHCWPSYSGE--RC-EVNHCS-NYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF 4292
Query: 929 CIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDG 988
C T +T Q H Q +Y ++++ C G G CV P
Sbjct: 4293 CQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYV--CHHYCVNSESCTIGDDGSVECVCPTR 4350
Query: 989 HEVP 992
+E P
Sbjct: 4351 YEGP 4354
Score = 40.4 bits (93), Expect = 0.012
Identities = 40/163 (24%), Positives = 55/163 (33%), Gaps = 38/163 (23%)
Query: 770 CDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCI-NLPGSYRCE 828
C+ RC D C C Y G+ C + N C+ + C C+ ++ G C
Sbjct: 4221 CENGGRCILNEKGDLRCHCWPSYSGE--RC-EVNHCS---NYCQNGGTCVPSVLGRPTCS 4274
Query: 829 CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGD-- 886
C G+ + T CED C G C+ G+ C C P Y GD
Sbjct: 4275 CALGFTGPNCGKTV---------CED---FCQNGG--TCIVTAGNQPYCHCQPEYTGDRC 4320
Query: 887 -----GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYG 924
H C + + C+ GS C C Y G
Sbjct: 4321 QYYVCHHYCVNSESCT----------IGDDGSVECVCPTRYEG 4353
Score = 38.9 bits (89), Expect = 0.034
Identities = 35/121 (28%), Positives = 47/121 (38%), Gaps = 20/121 (16%)
Query: 795 DGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCED 854
D R +N C C +++C+ +PG C C ++ TC NP E
Sbjct: 788 DPRKQQGDNMCRVNNGGC--STLCLAIPGGRVCACADNQLLDENGTTCTF-----NPGEA 840
Query: 855 GSHTCAPAGQARCV--HHGGSTFSC----ACLPGYAGD-----GHQCTDVD-ECSENRCH 902
H C AG+ RC H + + C CL G D H C D +C NRC
Sbjct: 841 LPHIC-KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCI 899
Query: 903 P 903
P
Sbjct: 900 P 900
Score = 38.9 bits (89), Expect = 0.034
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 41/223 (18%)
Query: 752 KEDSDPTPGNPCYDGSHMCDTTARCHPGTGV-DYTCECASGYQGDGRNCVDENECATGFH 810
+ED P N C C TT C V D +CA D NC D+ C
Sbjct: 3425 EEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADA--SDEANC-DKKTCGPHEF 3481
Query: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP--CE-----------DGSH 857
+C N+ CI P +RC+ ++ D C T C DG
Sbjct: 3482 QC-KNNNCI--PDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDF 3538
Query: 858 TCAPAGQARCVHHGGS--TFSCA---CLPG-YAGDGHQCTDVDECSENRCHPAA-TCYNT 910
CA R S F C+ C+P + DGH+ E E C PA+ TC +
Sbjct: 3539 DCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGE-DEKSCEPASPTCSSR 3597
Query: 911 PG--------SFSCRCQPGY-YGDGFQCIPDSTSSLTPCEQQQ 944
S S +C Y DG D +T C++ Q
Sbjct: 3598 EYICASDGCISASLKCNGEYDCADG----SDEMDCVTECKEDQ 3636
Score = 38.9 bits (89), Expect = 0.034
Identities = 49/193 (25%), Positives = 67/193 (34%), Gaps = 50/193 (25%)
Query: 767 SHMCDTTARCHPGTGVDYTCECASGYQGDGRNC---VDENECATGFHRCGPNSVCINLPG 823
S+ C C P TC CA G+ G NC V E+ C G CI G
Sbjct: 4254 SNYCQNGGTCVPSVLGRPTCSCALGFTGP--NCGKTVCEDFCQNG-------GTCIVTAG 4304
Query: 824 SY-RCECRSGYEFADDR---HTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCAC 879
+ C C+ E+ DR + C H C C + C C
Sbjct: 4305 NQPYCHCQP--EYTGDRCQYYVC-------------HHYC--VNSESCTIGDDGSVECVC 4347
Query: 880 LPGYAGDGHQCTDVDECSENRCHPA------------ATCYNTPGSFSCRCQPGYYGDGF 927
Y +G +C +VD+C RCH C N + SC+ GY +G
Sbjct: 4348 PTRY--EGPKC-EVDKCV--RCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGG 4402
Query: 928 QCIPDSTSSLTPC 940
C D +++ C
Sbjct: 4403 TCQLDPETNVPVC 4415
Score = 35.0 bits (79), Expect = 0.50
Identities = 26/111 (23%), Positives = 45/111 (40%), Gaps = 17/111 (15%)
Query: 762 PCYDGSHMCDTTARCHPGTGVDYTCE----CASGYQGDG-RNCVDENECATGFHRCGPNS 816
PC C + +C P +D C+ C G G R E C + CG ++
Sbjct: 3761 PCKKDEFAC-SNKKCIP---MDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDA 3816
Query: 817 VCINLPGSYRCECRSGYE------FADDRHTCILITPPANPC--EDGSHTC 859
C + S C C+ G++ +D + C++ ++ C +GS+ C
Sbjct: 3817 YCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
Score = 32.3 bits (72), Expect = 3.2
Identities = 20/80 (25%), Positives = 32/80 (40%), Gaps = 7/80 (8%)
Query: 770 CDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRC 827
C PG G+ C C G Q D + C + C+ +C + VC + +C
Sbjct: 1183 CSNHCSVVPGRGI--VCSCPEGLQLNKDNKTCEIVDYCSNHL-KC--SQVCEQHKHTVKC 1237
Query: 828 ECRSGYEFADDRHTCILITP 847
C G++ D +C + P
Sbjct: 1238 SCYEGWKLDVDGESCTSVDP 1257
Score = 32.3 bits (72), Expect = 3.2
Identities = 14/41 (34%), Positives = 18/41 (43%)
Query: 482 AANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKH 522
A + TCE N C A+C T C C+ F N K+
Sbjct: 3799 APTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKN 3839
Score = 32.0 bits (71), Expect = 4.2
Identities = 33/131 (25%), Positives = 47/131 (35%), Gaps = 30/131 (22%)
Query: 813 GPNSVCINLPG-SYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
G + +C+ PG ++ C C + + A D TC+ + A Q RC
Sbjct: 3283 GCSHLCLLAPGKTHTCACPTNFYLAADNRTCL--------------SNCTASQFRCKTDK 3328
Query: 872 GSTFSCAC-LPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCR----CQPGYYGDG 926
F C GDG + D+C E RC PG F C P + DG
Sbjct: 3329 CIPFWWKCDTVDDCGDGSD--EPDDCPEFRCQ--------PGRFQCGTGLCALPAFICDG 3378
Query: 927 FQCIPDSTSSL 937
D++ L
Sbjct: 3379 ENDCGDNSDEL 3389
Score = 31.6 bits (70), Expect = 5.5
Identities = 56/227 (24%), Positives = 74/227 (32%), Gaps = 55/227 (24%)
Query: 761 NPCYDGSHMCDTTA--------RCHPGTGVDYTCECASGYQ----GDGRNCVDENECA-- 806
N C D S D RC GT + + C D +NC + +C
Sbjct: 2575 NDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC-NNTDCTHF 2633
Query: 807 -------TGFHRCGPNSVCINLP-----GSYRC---------------ECRSGYEFADDR 839
TGF RC S+C+ LP GS C +C Y F+
Sbjct: 2634 YKLGVKTTGFIRCNSTSLCV-LPTWICDGSNDCGDYSDELKCPVQNKHKCEENY-FSCPS 2691
Query: 840 HTCIL---ITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDEC 896
CIL I CEDG S C C D +
Sbjct: 2692 GRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
Query: 897 SENRCHPAATCYNTPGSFSCR----CQPGYY-GDGFQCIPDSTSSLT 938
S++ C A TC FSC+ C P ++ DG + PD + L+
Sbjct: 2752 SDSIC-GAITC--AADMFSCQGSRACVPRHWLCDGERDCPDGSDELS 2795
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 148 bits (373), Expect = 4e-35
Identities = 143/515 (27%), Positives = 208/515 (40%), Gaps = 83/515 (16%)
Query: 527 GAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIV---GNDGRAYTA-ISHIPQPAAQALLP 582
G P R G V G+++ V F L+A I +D R A I+++P+ A+
Sbjct: 4870 GGPQRARGSVIGNIN----DVEFGIAFLNATITDSPNSDTRIIRAKITNVPRSLGSAMRK 4925
Query: 583 LTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYL 642
+ I W A E + NGF+L A F + +V F GE ++++ A GLD + L
Sbjct: 4926 IVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGE-ILQMSHIARGLDSDGSL 4984
Query: 643 SIKTNIQGQVPYVSANFTAHISPYKELY-HYSDSTVTSTSSRDYSLTFGAINQTWSYRIH 701
+ + G V + + + Y E Y + + S+R +++ +I TW++ +
Sbjct: 4985 LLDIVVSGYVLQLQSPAEVTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVF 5044
Query: 702 QNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAV---------TNQ----- 747
+ + R P T L+ V + YN E L F + +NQ
Sbjct: 5045 YD------QAQGRMPFLVET--LHASSVESDYNQIEETLGFKIHASISKGDRSNQCPSGF 5096
Query: 748 ----IGPVKEDSDP-TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCV 800
+GP D D GNPC SH C H G Y C C G DGR C
Sbjct: 5097 TLDSVGPFCADEDECAAGNPC---SHSC------HNAMGT-YYCSCPKGLTIAADGRTCQ 5146
Query: 801 DENECATGFHRCGPNSVCINLPGSYRC--ECRSGYEFADDRHTCILITPPANPCEDGSHT 858
D +ECA G H C C N GSYRC C SG+ D +C I N C++ S
Sbjct: 5147 DIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDI----NECQESS-- 5200
Query: 859 CAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSC-- 916
P Q RC + GS F C C PGY G +C DV+EC +N C P C NT G + C
Sbjct: 5201 --PCHQ-RCFNAIGS-FHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCID 5256
Query: 917 ------------------RCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARF 958
C+ G + + I ++T C + + P
Sbjct: 5257 LCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRP--CM 5314
Query: 959 HIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPG 993
I +C++ QC + G C+ P G + G
Sbjct: 5315 DINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLG 5349
Score = 75.9 bits (185), Expect = 3e-13
Identities = 60/190 (31%), Positives = 71/190 (37%), Gaps = 34/190 (17%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCIN 820
C DG+H C C G Y C C GY QG GR C+D NEC C C N
Sbjct: 5276 CKDGTHQCRYNQICENTRG-SYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSN 5332
Query: 821 LPGSYRCECRSGYEFADDRHTCI-LITPPANPCEDGSHTCA----------PAGQARCVH 869
PGS++C C G D +C L P + S+ A P R
Sbjct: 5333 TPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYS 5392
Query: 870 HGGSTFS-----------------CACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPG 912
H S++S C G C D+DEC EN C NT G
Sbjct: 5393 HLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDEC-ENTDACQHECKNTFG 5451
Query: 913 SFSCRCQPGY 922
S+ C C PGY
Sbjct: 5452 SYQCICPPGY 5461
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/87 (34%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 770 CDTTARCH---PGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGS 824
C+ T C T Y C C GYQ +G+ C D +EC CGPN +C N+ GS
Sbjct: 5436 CENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGS 5495
Query: 825 YRC---ECRSGYEFADDRHTCILITPP 848
Y+C C Y+ C+ PP
Sbjct: 5496 YQCIDTPCPPNYQRDPVSGFCLKNCPP 5522
Score = 39.3 bits (90), Expect = 0.026
Identities = 33/124 (26%), Positives = 46/124 (37%), Gaps = 13/124 (10%)
Query: 788 CASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITP 847
C G + CVD +EC + C N GSY+C C GY+ + TC
Sbjct: 5419 CPEGSEASHDTCVDIDECE---NTDACQHECKNTFGSYQCICPPGYQLTHNGKTC----Q 5471
Query: 848 PANPCEDGSHTCAPAGQARCVHHGGSTFSC---ACLPGYAGDGHQCTDVDECSENRCHPA 904
+ C + + C P C + GS + C C P Y D + C N A
Sbjct: 5472 DIDECLEQNVHCGP--NRMCFNMRGS-YQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECA 5528
Query: 905 ATCY 908
+ Y
Sbjct: 5529 LSPY 5532
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 147 bits (371), Expect = 7e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 570
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
Query: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
PF I + D + TD + + S N+ +G
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNG 659
Score = 53.9 bits (128), Expect = 1e-06
Identities = 56/198 (28%), Positives = 69/198 (34%), Gaps = 39/198 (19%)
Query: 760 GNPCYDGSHMCDTTARCH------------PGTGVDYT-CECASGYQGDGRNCVDENECA 806
G C +CD C PG G CA+ Q R+ EC
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS----GECV 273
Query: 807 TGFHRCGPNSVCINLPGSYRCE---CRSGYEFADDRHTCILITPPANP---CEDGSHTCA 860
RC + C + C CR G EF TC+L N C DGS
Sbjct: 274 HLGWRCDGDRDCKDKSDEADCPLGTCR-GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
Query: 861 PA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATC 907
G C+H+ G F C C G+ D C D+DEC + + C + C
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQIC 390
Query: 908 YNTPGSFSCRCQPGYYGD 925
N G F C C PGY D
Sbjct: 391 VNYKGYFKCECYPGYEMD 408
Score = 42.0 bits (97), Expect = 0.004
Identities = 49/186 (26%), Positives = 63/186 (33%), Gaps = 40/186 (21%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
D D P C D CD H D EC G C + C CG
Sbjct: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT-KQVCPAEKLSCG 135
Query: 814 PNS-VCINLPGSYRC----ECRSG------------YEFADDRHTC---ILITPPANPCE 853
P S C+ P S+RC +C G +EF +C + + + C
Sbjct: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
Query: 854 DGSH-------TCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAAT 906
DGS C P + RC GG AC+P + C +C E+R AA
Sbjct: 194 DGSDERGCADPACGPR-EFRCGGDGGG----ACIP----ERWVCDRQFDC-EDRSDEAAE 243
Query: 907 CYNTPG 912
PG
Sbjct: 244 LCGRPG 249
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 147 bits (371), Expect = 7e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 323 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 441
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 442 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 501
Query: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
PF I + D + TD + + S N+ +G
Sbjct: 502 PFGIAVFEDKVFWTDLENEAIFSANRLNG 530
Score = 68.2 bits (165), Expect = 5e-11
Identities = 61/209 (29%), Positives = 73/209 (34%), Gaps = 43/209 (20%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
D D P C D CD H D EC G C + C CG
Sbjct: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ-VCPAEKLSCG 135
Query: 814 PNS-VCINLPGSYRCE--------------------CRSGYEFADDRHTCILITPPANP- 851
P S C+ P S+RC+ CR G EF TC+L N
Sbjct: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATSLGTCR-GDEFQCGDGTCVLAIKHCNQE 192
Query: 852 --CEDGSHTCAPA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECS 897
C DGS G C+H+ G F C C G+ D C D+DEC
Sbjct: 193 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 252
Query: 898 E-NRCHPAATCYNTPGSFSCRCQPGYYGD 925
+ + C + C N G F C C PGY D
Sbjct: 253 DPDAC--SQICVNYKGYFKCECYPGYEMD 279
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 147 bits (371), Expect = 7e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 282 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 400
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 401 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 460
Query: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
PF I + D + TD + + S N+ +G
Sbjct: 461 PFGIAVFEDKVFWTDLENEAIFSANRLNG 489
Score = 60.5 bits (145), Expect = 1e-08
Identities = 51/176 (28%), Positives = 60/176 (34%), Gaps = 18/176 (10%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
D D P C D CD H D EC G C + C CG
Sbjct: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ-VCPAEKLSCG 135
Query: 814 PNS-VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDG-SHTCAPAGQARCVHHG 871
P S C+ P S+RC+ E D C G SH C
Sbjct: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIG------ 187
Query: 872 GSTFSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGYYGD 925
F C C G+ D C D+DEC + + C + C N G F C C PGY D
Sbjct: 188 ---FECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYPGYEMD 238
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 30/117 (25%)
Query: 745 TNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTG----------------------- 781
T Q+ P ++ S + C S CD C G
Sbjct: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICT 182
Query: 782 ---VDYTCECASGYQG-DGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYE 834
+ + C C +G+Q D + C D +EC C + +C+N G ++CEC GYE
Sbjct: 183 DLKIGFECTCPAGFQLLDQKTCGDIDECKDP-DAC--SQICVNYKGYFKCECYPGYE 236
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 147 bits (371), Expect = 7e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 570
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
Query: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
PF I + D + TD + + S N+ +G
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNG 659
Score = 53.9 bits (128), Expect = 1e-06
Identities = 56/198 (28%), Positives = 69/198 (34%), Gaps = 39/198 (19%)
Query: 760 GNPCYDGSHMCDTTARCH------------PGTGVDYT-CECASGYQGDGRNCVDENECA 806
G C +CD C PG G CA+ Q R+ EC
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS----GECV 273
Query: 807 TGFHRCGPNSVCINLPGSYRCE---CRSGYEFADDRHTCILITPPANP---CEDGSHTCA 860
RC + C + C CR G EF TC+L N C DGS
Sbjct: 274 HLGWRCDGDRDCKDKSDEADCPLGTCR-GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
Query: 861 PA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATC 907
G C+H+ G F C C G+ D C D+DEC + + C + C
Sbjct: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQIC 390
Query: 908 YNTPGSFSCRCQPGYYGD 925
N G F C C PGY D
Sbjct: 391 VNYKGYFKCECYPGYEMD 408
Score = 42.0 bits (97), Expect = 0.004
Identities = 49/186 (26%), Positives = 63/186 (33%), Gaps = 40/186 (21%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
D D P C D CD H D EC G C + C CG
Sbjct: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT-KQVCPAEKLSCG 135
Query: 814 PNS-VCINLPGSYRC----ECRSG------------YEFADDRHTC---ILITPPANPCE 853
P S C+ P S+RC +C G +EF +C + + + C
Sbjct: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
Query: 854 DGSH-------TCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAAT 906
DGS C P + RC GG AC+P + C +C E+R AA
Sbjct: 194 DGSDERGCADPACGPR-EFRCGGDGGG----ACIP----ERWVCDRQFDC-EDRSDEAAE 243
Query: 907 CYNTPG 912
PG
Sbjct: 244 LCGRPG 249
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 145 bits (366), Expect = 3e-34
Identities = 82/240 (34%), Positives = 134/240 (55%), Gaps = 8/240 (3%)
Query: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
FLL+ Q I ++ +GT TLLS ++ +D+D E +Y+ A + I R
Sbjct: 484 FLLFANSQDIRHMHFDGTDYG-----TLLSQQMGMVYALDHDPVENKIYFAHTALKWIER 538
Query: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDL 1228
A ++ G++ E ++ G+ PEGLA+D I R YWTD I + L+G K++ ++
Sbjct: 539 ANMD-GSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENI 597
Query: 1229 VNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLL 1288
PR IAV P+ L+WTD P+IE+SSL G R ++ ++D+ P+G+T D + L
Sbjct: 598 SQPRGIAVHPMAKRLFWTDTGIN-PRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKL 656
Query: 1289 CWADAGTKKLECTLPDGT-GRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQ 1347
W DA +E DG+ RR+ QN++ +PF++ + D+ + +DW V+ VNK +G+
Sbjct: 657 YWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGK 716
Score = 81.3 bits (199), Expect = 6e-15
Identities = 64/236 (27%), Positives = 85/236 (36%), Gaps = 71/236 (30%)
Query: 813 GPNSVCINLPGSYRCECRSGYEFADDRHTCIL-----------------ITP-----PAN 850
G +C G+ C CR G+ A D TC+ +TP
Sbjct: 751 GCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTR 810
Query: 851 PCEDG----------------SHTCAPAG---QARCVHHGGSTFSCACLPGYAGDGHQCT 891
ED CAP G ARC+ G +C CL G+AGDG C+
Sbjct: 811 VSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA-TCQCLKGFAGDGKLCS 869
Query: 892 DVDECSEN--RCHPAAT-CYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQ 948
D+DEC C PA++ C NT G + CRC GY GDG C+ + C+ +
Sbjct: 870 DIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCL-----DIDECQLGEH--- 921
Query: 949 AQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPH 1004
C E + C + G C+ PG P + PPH
Sbjct: 922 -------------SCGENAS-----CTNTEGGYTCMCAGRLSEPGLICPDSTPPPH 959
Score = 80.5 bits (197), Expect = 1e-14
Identities = 46/146 (31%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C G +C + T Y C C+ GYQGDG +C+D +EC G H CG N+ C N
Sbjct: 874 CEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTE 933
Query: 823 GSYRCECRSGYEFADDRHTCILITPPANPCEDGSH--------TCAPAGQARCVHHGG-- 872
G Y C C ++ C TPP + ED H C + C+H G
Sbjct: 934 GGYTCMCAG--RLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCM 991
Query: 873 -----STFSCACLPGYAGDGHQCTDV 893
++C C+ GY G+ Q D+
Sbjct: 992 YIEALDKYACNCVVGYIGERCQYRDL 1017
Score = 74.3 bits (181), Expect = 7e-13
Identities = 46/124 (37%), Positives = 60/124 (48%), Gaps = 11/124 (8%)
Query: 770 CDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGP-NSVCINLPGSYRCE 828
C ARC G D TC+C G+ GDG+ C D +EC G C P +S CIN G Y C
Sbjct: 840 CSMYARCI-SEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCR 898
Query: 829 CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGH 888
C GY+ D H C+ I + C+ G H+C A C + G ++C C + G
Sbjct: 899 CSEGYQ-GDGIH-CLDI----DECQLGEHSCGE--NASCTNTEGG-YTCMCAGRLSEPGL 949
Query: 889 QCTD 892
C D
Sbjct: 950 ICPD 953
Score = 70.1 bits (170), Expect = 1e-11
Identities = 57/247 (23%), Positives = 111/247 (44%), Gaps = 23/247 (9%)
Query: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
FL+++ G I + GT ++ L + + V +D+ E+ +YW D+ + + R
Sbjct: 47 FLIFSHGNSIFRIDTEGTNYEQ------LVVDAGVSVIMDFHYNEKRIYWVDLERQLLQR 100
Query: 1169 AGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDL 1228
L G+ E + N + G+AI+ I + W++ I + G+ +L + L
Sbjct: 101 VFLN-GSRQERVCNIEK-NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL-SAL 157
Query: 1229 VNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLL 1288
P +AVDP+ ++W+ + A + + LDG + L+ T + ++ D K L
Sbjct: 158 KYPANVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRL 214
Query: 1289 CWAD---AGTKKLECTLPDGTG-----RRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVS 1340
W G+ L C+ G + Q+NL F++ + D +++ W+ +
Sbjct: 215 FWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNL---FAMSLFGDRIFYSTWKMKTIWI 271
Query: 1341 VNKHSGQ 1347
NKH+G+
Sbjct: 272 ANKHTGK 278
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/144 (31%), Positives = 55/144 (38%), Gaps = 18/144 (12%)
Query: 784 YTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
+ C CA GY D + C D NECA H C C N PGSY C C G+ D
Sbjct: 337 HLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG--CKNTPGSYYCTCPVGFVLLPDGKR 394
Query: 842 C-ILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPG--YAGDGHQCTDVDECSE 898
C L++ P N E SH C + C C G DG C+
Sbjct: 395 CHQLVSCPRNVSE-CSHDCVLTSEGPL---------CFCPEGSVLERDGKTCSGCSSPDN 444
Query: 899 NRCHPAATCYNTPGSFSCRCQPGY 922
C +P S+ C C PGY
Sbjct: 445 GGCSQLCVPL-SPVSWECDCFPGY 467
Score = 40.4 bits (93), Expect = 0.012
Identities = 36/132 (27%), Positives = 48/132 (36%), Gaps = 13/132 (9%)
Query: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
++VC S+ C C GY + DR C N C +H C C + GS
Sbjct: 327 STVCGQDLQSHLCMCAEGYALSRDRKYC----EDVNECAFWNHGCT----LGCKNTPGS- 377
Query: 875 FSCACLPGYA--GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPG--YYGDGFQCI 930
+ C C G+ DG +C + C N + C T C C G DG C
Sbjct: 378 YYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
Query: 931 PDSTSSLTPCEQ 942
S+ C Q
Sbjct: 438 GCSSPDNGGCSQ 449
Score = 30.8 bits (68), Expect = 9.4
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 7/65 (10%)
Query: 786 CECASG--YQGDGRNCVDENECATGFHRCGPNSVCINL-PGSYRCECRSGYEFADDRHTC 842
C C G + DG+ C + G G + +C+ L P S+ C+C GY+ D +C
Sbjct: 421 CFCPEGSVLERDGKTCSGCSSPDNG----GCSQLCVPLSPVSWECDCFPGYDLQLDEKSC 476
Query: 843 ILITP 847
P
Sbjct: 477 AASGP 481
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 133 bits (334), Expect = 1e-30
Identities = 68/205 (33%), Positives = 111/205 (54%), Gaps = 4/205 (1%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
V +D D + ++W D++ + I A ++ + + +P +A+D + +T+YWTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
+ I A LDG++RK LF +DL P +IAVDP+ G +YW+DW E KIE + ++G +
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGFD 590
Query: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKY---PFSI 1321
RR L+ DI PNG+T D L W D+ L +G RR++ +L++ P ++
Sbjct: 591 RRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLAL 650
Query: 1322 VSYADHFYHTDWRRDGVVSVNKHSG 1346
+ D Y D + V NK +G
Sbjct: 651 TIFEDRVYWIDGENEAVYGANKFTG 675
Score = 48.5 bits (114), Expect = 4e-05
Identities = 55/192 (28%), Positives = 74/192 (38%), Gaps = 42/192 (21%)
Query: 754 DSDPTPGNPCYDGSHMCDTTAR-CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRC 812
D DP C DGS + +R C P + CE S G R C +C G
Sbjct: 259 DGDPD----CKDGSDEVNCPSRTCRPD---QFECEDGSCIHGS-RQCNGIRDCVDGSDEV 310
Query: 813 GPNSV--CINLPGSYRCECRSGYEFADDRHTCILITPPANP---CEDGSHTCAPAGQARC 867
+V C+ PG ++C RSG CI I+ N C D S P +
Sbjct: 311 NCKNVNQCLG-PGKFKC--RSG--------ECIDISKVCNQEQDCRDWSDE--PLKECHI 357
Query: 868 ----VHHGGST---------FSCACLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGS 913
V++GG + + C C G+ D C D+DEC +N + C N G
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
Query: 914 FSCRCQPGYYGD 925
+ C C GY D
Sbjct: 417 YKCECSRGYQMD 428
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 133 bits (334), Expect = 1e-30
Identities = 68/205 (33%), Positives = 111/205 (54%), Gaps = 4/205 (1%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
V +D D + ++W D++ + I A ++ + + +P +A+D + +T+YWTD
Sbjct: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
+ I A LDG++RK LF +DL P +IAVDP+ G +YW+DW E KIE + ++G +
Sbjct: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGFD 590
Query: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKY---PFSI 1321
RR L+ DI PNG+T D L W D+ L +G RR++ +L++ P ++
Sbjct: 591 RRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLAL 650
Query: 1322 VSYADHFYHTDWRRDGVVSVNKHSG 1346
+ D Y D + V NK +G
Sbjct: 651 TIFEDRVYWIDGENEAVYGANKFTG 675
Score = 48.5 bits (114), Expect = 4e-05
Identities = 55/192 (28%), Positives = 74/192 (38%), Gaps = 42/192 (21%)
Query: 754 DSDPTPGNPCYDGSHMCDTTAR-CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRC 812
D DP C DGS + +R C P + CE S G R C +C G
Sbjct: 259 DGDPD----CKDGSDEVNCPSRTCRPD---QFECEDGSCIHGS-RQCNGIRDCVDGSDEV 310
Query: 813 GPNSV--CINLPGSYRCECRSGYEFADDRHTCILITPPANP---CEDGSHTCAPAGQARC 867
+V C+ PG ++C RSG CI I+ N C D S P +
Sbjct: 311 NCKNVNQCLG-PGKFKC--RSG--------ECIDISKVCNQEQDCRDWSDE--PLKECHI 357
Query: 868 ----VHHGGST---------FSCACLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGS 913
V++GG + + C C G+ D C D+DEC +N + C N G
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
Query: 914 FSCRCQPGYYGD 925
+ C C GY D
Sbjct: 417 YKCECSRGYQMD 428
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 129 bits (324), Expect = 2e-29
Identities = 70/209 (33%), Positives = 112/209 (53%), Gaps = 7/209 (3%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELG---AEPETIVNSGLISPEGLAIDHIRRTM 1200
+V +D + +YW+D++ R I L+ + +T+++ + +P+GLA+D I +
Sbjct: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
YWTDSVL + A G +RK LF + PRAI VDP+ G +YWTDW A KI+ L
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA-KIKKGGL 547
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI---QNNLKY 1317
+G + L+ +I PNG+T D S L W D+ + +G R+ I + L +
Sbjct: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
PFS+ + D + TD + + S N+ +G
Sbjct: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTG 636
Score = 53.1 bits (126), Expect = 2e-06
Identities = 110/520 (21%), Positives = 173/520 (33%), Gaps = 96/520 (18%)
Query: 770 CDTTARCHPGTGV-DYTCECASGYQGDGRNC-VDENECATGFHRCGPNSVCINLPGSYRC 827
CD C G+ C +QGD C E C +G CI+ S+RC
Sbjct: 167 CDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG--------ECIH--SSWRC 216
Query: 828 ECRSGYEFADDRHTCILIT--PPANPCEDGS-----------HTCAP-AGQARCVH---- 869
+ + D C + T P C DG+ + C + + CV+
Sbjct: 217 DGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLC 276
Query: 870 HGGSTFSC-----ACLPGYAGDGHQCTD-----VDECSENRCHP-----AATCYNTPGSF 914
G + F C L C D + EC N C + C + +
Sbjct: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGY 336
Query: 915 SCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQC 974
C C DGFQ + CE I +C + L C
Sbjct: 337 ECLCP-----DGFQLVAQRR-----CED-----------------IDECQDPDTCSQL-C 368
Query: 975 HGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTP 1034
G C +G ++ P + + +I + N E T
Sbjct: 369 VNLEGGYKCQCEEGFQLD--------------PHTKACKAVGSIAYLFFTNRHEVRKMTL 414
Query: 1035 RDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR 1094
+Y +L + + L S+ + D R + T+ + TV + R
Sbjct: 415 DRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTV---ISR 471
Query: 1095 PTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRER 1154
PD +Y +G + + T+ K KTL +GS I D
Sbjct: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVK--RKTLFRENGSKPRAIVVDPVHG 529
Query: 1155 MVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESAL 1214
+YWTD + G G + ++V + P G+ +D + +YW DS L I S
Sbjct: 530 FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
Query: 1215 LDGSERKVLFYTD--LVNPRAIAVDPIRGNLYWTDWNREA 1252
++G RK + + L +P ++AV ++WTD EA
Sbjct: 590 VNGGNRKTILEDEKRLAHPFSLAV--FEDKVFWTDIINEA 627
Score = 45.1 bits (105), Expect = 5e-04
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 21/97 (21%)
Query: 750 PVKEDSDPTPGNPCYDG----SHMCDTTARCHPGTGVDYTCECASGYQGDG-RNCVDENE 804
P+KE N C D SH+C+ + Y C C G+Q R C D +E
Sbjct: 309 PIKECGT----NECLDNNGGCSHVCNDLK-------IGYECLCPDGFQLVAQRRCEDIDE 357
Query: 805 CATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
C C + +C+NL G Y+C+C G++ D HT
Sbjct: 358 CQDP-DTC--SQLCVNLEGGYKCQCEEGFQL--DPHT 389
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/183 (23%), Positives = 65/183 (35%), Gaps = 25/183 (13%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C S CD C + + C A+ + D C D N C G +C C ++
Sbjct: 209 CIHSSWRCDGGPDCKDKSDEE-NCAVAT-CRPDEFQCSDGN-CIHGSRQCDREYDCKDMS 265
Query: 823 GSYRCE----CRSGYEFADDRHTCILITPPAN---PCEDGS-HTCAPAGQARCVHHGGST 874
C C +F CI + N C D S G C+ + G
Sbjct: 266 DEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGC 325
Query: 875 ----------FSCACLPGYAGDGHQ-CTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
+ C C G+ + C D+DEC + + C + C N G + C+C+ G+
Sbjct: 326 SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTC--SQLCVNLEGGYKCQCEEGF 383
Query: 923 YGD 925
D
Sbjct: 384 QLD 386
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 127 bits (320), Expect = 6e-29
Identities = 73/215 (33%), Positives = 116/215 (53%), Gaps = 5/215 (2%)
Query: 1153 ERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIES 1212
E VYWTD I RA L+ G+ +T++N+ + P+ +A++ + R++YWT + + IE
Sbjct: 2 EGHVYWTDDEVWAIRRAYLD-GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1213 ALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1272
L+ + K+L D+ PRAIA+ P G YW DW E P+I+ ++LD + R+L+N
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNAS 119
Query: 1273 IGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHT 1331
+G PNGL D L W DA T K+E D T R+ ++++ L + F D Y T
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 1332 DWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
W+ + V H + + + +Q L G+ AV
Sbjct: 180 AWQHHSIKRV--HKVKANRDVIIDQLPDLMGLKAV 212
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 127 bits (320), Expect = 6e-29
Identities = 73/215 (33%), Positives = 116/215 (53%), Gaps = 5/215 (2%)
Query: 1153 ERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIES 1212
E VYWTD I RA L+ G+ +T++N+ + P+ +A++ + R++YWT + + IE
Sbjct: 2 EGHVYWTDDEVWAIRRAYLD-GSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 1213 ALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTD 1272
L+ + K+L D+ PRAIA+ P G YW DW E P+I+ ++LD + R+L+N
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWG-ENPEIKRANLDRQELRVLVNAS 119
Query: 1273 IGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVSYADHFYHT 1331
+G PNGL D L W DA T K+E D T R+ ++++ L + F D Y T
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 1332 DWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
W+ + V H + + + +Q L G+ AV
Sbjct: 180 AWQHHSIKRV--HKVKANRDVIIDQLPDLMGLKAV 212
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 126 bits (317), Expect = 1e-28
Identities = 80/237 (33%), Positives = 119/237 (50%), Gaps = 16/237 (6%)
Query: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWT 1203
+V +D+D E+ +YW D + I R L ETI+N L + E LA+D + R +YW
Sbjct: 3229 VVALDFDRVEKRLYWIDTQRQVIERMFLNK-TNKETIINHRLPAAESLAVDWVSRKLYWL 3287
Query: 1204 DSVLDKIESALLDGSERKVL----------FYTDLVNPRAIAVDPIRGNLYWTDWNREAP 1253
D+ LD + + L+G R++L F D NPR +A+ P G LYW DW A
Sbjct: 3288 DARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFD--NPRGLALHPQYGYLYWADWGHRA- 3344
Query: 1254 KIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN 1313
I +DG N+ ++I+T + PNG+T D + LL WADA +E + +G R + +
Sbjct: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
Query: 1314 N-LKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPY 1369
L +PF+I + D Y TDW V NK+ G + L + I +PY
Sbjct: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGS-NRQTLVNTTHRPFDIHVYHPY 3460
Score = 124 bits (311), Expect = 6e-28
Identities = 79/235 (33%), Positives = 127/235 (54%), Gaps = 10/235 (4%)
Query: 1140 HGSIIVGIDYDCRERMVYWTDVA-GRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRR 1198
+GS IV +D+D ++W+D G+T S + G + + +S +I E +AID + R
Sbjct: 1464 NGSYIVAVDFDSISGRIFWSDATQGKTWS--AFQNGTDRRVVFDSSIILTETIAIDWVGR 1521
Query: 1199 TMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN--LYWTDWNREAPKIE 1256
+YWTD L+ IE + +DGS R VL +L NPR +A+DP L+W+DW P+IE
Sbjct: 1522 NLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHH-PRIE 1580
Query: 1257 TSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLE-CTLPDGTGRRVIQNNL 1315
+S+DG R +++ I P GLT D ++LL + D+ ++ C R+VI ++L
Sbjct: 1581 RASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDL 1640
Query: 1316 --KYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYP 1368
++P+++ + D Y TD V+ NK G + + L GI AV+P
Sbjct: 1641 IIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPL-GIVAVHP 1694
Score = 123 bits (309), Expect = 1e-27
Identities = 71/206 (34%), Positives = 108/206 (52%), Gaps = 6/206 (2%)
Query: 1144 IVGIDYDCRERMVYWTDVAGR---TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTM 1200
++ +DYD +Y+T IS A L G T++ SG+ + +G+A D I R +
Sbjct: 2421 VMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRI 2480
Query: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Y++D + I S DGS R V+ + PRAI +DP +G LYW DW+ A KIE ++L
Sbjct: 2481 YYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHA-KIERATL 2537
Query: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS 1320
G R ++N+ + +P+GLT D LL W DA +++E + G R VI N + F
Sbjct: 2538 GGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFG 2597
Query: 1321 IVSYADHFYHTDWRRDGVVSVNKHSG 1346
+ Y + Y TD + NK+ G
Sbjct: 2598 LTLYGQYIYWTDLYTQRIYRANKYDG 2623
Score = 123 bits (308), Expect = 1e-27
Identities = 79/245 (32%), Positives = 129/245 (52%), Gaps = 9/245 (3%)
Query: 1105 SVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGR 1164
+V FL+++ I +P T ++ +S + S VGID+D ++ ++++D++
Sbjct: 706 AVQNFLIFSSQVAIRGIPF--TLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKH 763
Query: 1165 TISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIE-SALLDGSERKVL 1223
I + ++ G E + + + + E LA D I + +YWTDS I L D + R V+
Sbjct: 764 MIFKQKID-GTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV 822
Query: 1224 FYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDP 1283
Y L NPR++ V P G L++TDW R A KI + DG + +INT +G PNGL D
Sbjct: 823 QY--LNNPRSVVVHPFAGYLFFTDWFRPA-KIMRAWSDGSHLLPVINTTLGWPNGLAIDW 879
Query: 1284 FSKLLCWADAGTKKLECTLPDGTGRRVIQN--NLKYPFSIVSYADHFYHTDWRRDGVVSV 1341
+ L W DA K+E + DG RR + + + +PF + + +H + TDWR ++ V
Sbjct: 880 AASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRV 939
Query: 1342 NKHSG 1346
K G
Sbjct: 940 RKADG 944
Score = 122 bits (307), Expect = 2e-27
Identities = 68/235 (28%), Positives = 120/235 (51%), Gaps = 7/235 (2%)
Query: 1138 SLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIR 1197
S + + VG+ + + V+WTD + + G + ++N + +PE LA+D +
Sbjct: 420 SQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDIN-GLNIQEVLNVSVETPENLAVDWVN 478
Query: 1198 RTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREA--PKI 1255
+Y ++ +++I+ LDGS R L +L +PR IAVDP G L+++DW + PK+
Sbjct: 479 NKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKL 538
Query: 1256 ETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN- 1314
E + +DG NR+ L+ T +G P G+T D SK + W D+ +E DG R+ + +
Sbjct: 539 ERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGG 598
Query: 1315 --LKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVY 1367
+ +PF + + + TDW + V+ NK + Y + YG+T +
Sbjct: 599 SLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYY-QASLRPYGVTVYH 652
Score = 117 bits (293), Expect = 8e-26
Identities = 64/160 (40%), Positives = 93/160 (58%), Gaps = 2/160 (1%)
Query: 1185 LISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLY 1244
++ P+G+A+D + R +YW+D +IE A LDG RK L TDL P AIAV+P G ++
Sbjct: 4141 VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF 4200
Query: 1245 WTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSK-LLCWADAGTKKLECTLP 1303
WTDW +E PKIE++ ++GE+R IL+ D+G P GL+ D + + W+D +E
Sbjct: 4201 WTDWGKE-PKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKY 4259
Query: 1304 DGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNK 1343
DGT RRVI P+S+ + D Y + V NK
Sbjct: 4260 DGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNK 4299
Score = 84.0 bits (206), Expect = 9e-16
Identities = 67/249 (26%), Positives = 113/249 (45%), Gaps = 15/249 (6%)
Query: 1109 FLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISR 1168
FL+ + I + LN DA + + + +++D E+ +YW + G I R
Sbjct: 1747 FLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGL--DVEFDDAEQYIYWVENPGE-IHR 1803
Query: 1169 AGLELGAEPETIVNSGLISPE-GLAIDHIRRTMYWTDSVLDKIESALLDGS--ERKVLFY 1225
+ G + ++ P LA+D I R +Y T+ IE L G RK L
Sbjct: 1804 VKTD-GTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIA 1862
Query: 1226 TD-----LVNPRAIAVDPIRGNLYWTDWNREA---PKIETSSLDGENRRILINTDIGLPN 1277
D + P I VDP RG LYW+D ++ KI ++++DG + + L ++
Sbjct: 1863 NDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLE 1922
Query: 1278 GLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDG 1337
+T D + L WA G +E DGT R ++ + L +P+ I + Y+TD + +
Sbjct: 1923 CVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEV 1982
Query: 1338 VVSVNKHSG 1346
+ V+K +G
Sbjct: 1983 IERVDKATG 1991
Score = 75.1 bits (183), Expect = 4e-13
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 11/198 (5%)
Query: 1131 DAAKTLLSL--HGSIIVGIDYDCRERMVYWTDVAGRTISRAGLEL----GAEPETIVNSG 1184
D ++T++ + G + +D D +YW D + S + G+ IV G
Sbjct: 2082 DHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHG 2141
Query: 1185 L--ISPEGLAIDHIRRTMYWTDSVLDK--IESALLDGSERKVLFYTDLVNPRAIAVDPIR 1240
+ G+A+D + +Y+T++ + + IE ++ + R+VL + PR I VDP
Sbjct: 2142 IGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKN 2201
Query: 1241 GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLEC 1300
L+W D+ + PKIE S LD NR +L++ I P GL D + W D +
Sbjct: 2202 RYLFWADYGQR-PKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
Query: 1301 TLPDGTGRRVIQNNLKYP 1318
+G VI+ +YP
Sbjct: 2261 IRINGENSEVIRYGSRYP 2278
Score = 72.8 bits (177), Expect = 2e-12
Identities = 46/147 (31%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 1146 GIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD- 1204
GI D R +YW+DV + I A L+ G + ++++ L P +A++ M+WTD
Sbjct: 4146 GIAVDWVGRHIYWSDVKNKRIEVAKLD-GRYRKWLISTDLDQPAAIAVNPKLGLMFWTDW 4204
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGN-LYWTDWNREAPKIETSSLDGE 1263
KIESA ++G +R +L + DL P +++D + + +YW+D+ + IET DG
Sbjct: 4205 GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDV--IETIKYDGT 4262
Query: 1264 NRRILINTDIGLPNGLTFDPFSKLLCW 1290
+RR++ + N + D F L W
Sbjct: 4263 DRRVIAKEAM---NPYSLDIFEDQLYW 4286
Score = 60.1 bits (144), Expect = 1e-08
Identities = 46/157 (29%), Positives = 62/157 (39%), Gaps = 34/157 (21%)
Query: 799 CVDENECATG----FHRCG-PNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCE 853
C ++N+C G H C P C +EF D CI + N +
Sbjct: 3051 CDEDNDCGDGSDELMHLCHTPEPTC------------PPHEFKCDNGRCIEMMKLCNHLD 3098
Query: 854 D----------GSHTCAPAGQARCVHHGGST---FSCACLPGYA--GDGHQCTDVDECSE 898
D G + C + C H+ T F C+C PGY D C D+DEC+E
Sbjct: 3099 DCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE 3158
Query: 899 NRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCIPDS 933
+ C N GS+ C+C PGY DG C +S
Sbjct: 3159 MPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNS 3195
Score = 52.8 bits (125), Expect = 2e-06
Identities = 59/211 (27%), Positives = 75/211 (35%), Gaps = 53/211 (25%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTC---ECASGY-QGDGRNCV----------------DE 802
C CD C G+ C C S Y D NC+ DE
Sbjct: 1243 CIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE 1302
Query: 803 NECATGFHRCGP-------NSVCINLPGSYRCE----CRSGYEFADDRHTCILITPPANP 851
+C T RC +++C+NL S C+ C +G D+ C N
Sbjct: 1303 KDCPTQPFRCPSWQWQCLGHNICVNL--SVVCDGIFDCPNG---TDESPLC-----NGNS 1352
Query: 852 CEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSE-NRCHPAATCY 908
C D + C CV C C G+ A D C D+DEC C + CY
Sbjct: 1353 CSDFNGGCTH----ECVQEPFGA-KCLCPLGFLLANDSKTCEDIDECDILGSC--SQHCY 1405
Query: 909 NTPGSFSCRCQPGYY--GDGFQCIPDSTSSL 937
N GSF C C GY DG C ++ SL
Sbjct: 1406 NMRGSFRCSCDTGYMLESDGRTCKVTASESL 1436
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/90 (32%), Positives = 48/90 (53%), Gaps = 4/90 (4%)
Query: 1180 IVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTD-LVNPRAIAVDP 1238
++N+ L P GLAID +YW D+ DKIE + DG +R+ L + + + +P +A+
Sbjct: 864 VINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAI-- 921
Query: 1239 IRGNLYWTDWNREAPKIETSSLDGENRRIL 1268
+L++TDW R I DG ++
Sbjct: 922 FGEHLFFTDW-RLGAIIRVRKADGGEMTVI 950
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/210 (23%), Positives = 72/210 (34%), Gaps = 56/210 (26%)
Query: 763 CYDGS----HMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVC 818
C DGS H+C +D C + ++ D C+ +E G CG +
Sbjct: 3867 CGDGSDEELHLC-----------LDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGT-- 3913
Query: 819 INLPGSYRCECR-------SGYEFADDRHTCILITPPANPCEDGS--------------- 856
CR + YE+ CI P N C+D
Sbjct: 3914 ----DETEEHCRKPTPKPCTEYEYKCGNGHCI---PHDNVCDDADDCGDWSDELGCNKGK 3966
Query: 857 -HTCAP-AGQARCVHHGGSTFSCACLPGYAG---DGHQCTDVDECSENRCHPAATCYNTP 911
TCA + C F C+C G+ D C D++EC + P C NT
Sbjct: 3967 ERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH-CRNTK 4025
Query: 912 GSFSCRCQPGYYG----DGFQCIPDSTSSL 937
GS+ C C G+ G +C + +S L
Sbjct: 4026 GSYECVCADGFTSMSDRPGKRCAAEGSSPL 4055
Score = 47.4 bits (111), Expect = 1e-04
Identities = 31/89 (34%), Positives = 38/89 (42%), Gaps = 16/89 (17%)
Query: 761 NPCYDGS-----HMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCG 813
N C+D S H C T + C C GY+ D R CVD +EC C
Sbjct: 3112 NECHDPSISGCDHNCTDTL-------TSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVC- 3163
Query: 814 PNSVCINLPGSYRCECRSGYEFADDRHTC 842
+ C N+ GSY C+C GY D TC
Sbjct: 3164 -SQKCENVIGSYICKCAPGYLREPDGKTC 3191
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/219 (22%), Positives = 73/219 (33%), Gaps = 49/219 (22%)
Query: 755 SDPTPGNPCYDGSHMCDTTARCHPGTG------VDYTCECASGYQGDGRNCVDENECATG 808
S P C ++CD CH + ++ TC ++ G G EC
Sbjct: 1030 SFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHG-------ECIPA 1082
Query: 809 FHRCGPNSVCINLPGSYRCECRS-----GYEFADDRHTCI---LITPPANPCEDGS---- 856
RC + C++ + C + ++ D H CI + N C DGS
Sbjct: 1083 HWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKN 1142
Query: 857 ----HTCAPAGQARCVHHG--GSTFSC-------------ACLPGYAGDGHQCTDVDEC- 896
TC P+ Q C +H +F C C+ +C D+C
Sbjct: 1143 CNSTETCQPS-QFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCI 1201
Query: 897 -SENRCHPAATCYNTPGSFSCRCQPG--YYGDGFQCIPD 932
NRC C + C +P + D FQC D
Sbjct: 1202 GVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQED 1240
Score = 44.7 bits (104), Expect = 6e-04
Identities = 53/189 (28%), Positives = 69/189 (36%), Gaps = 44/189 (23%)
Query: 761 NPCYDGS--HMCDTTARCHPGTGVDYTCECASG---YQG-------DGRNCVDENECATG 808
N C DGS H C+ +P G Y C SG YQ D ++ DE+ C +G
Sbjct: 206 NDCQDGSDEHACN-----YPTCG-GYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESG 259
Query: 809 ---FHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA 865
H+C P + P S RC S Y+ D C P E+ + T
Sbjct: 260 PHDVHKCSPREW--SCPESGRCI--SIYKVCDGILDC-----PGREDENNTSTGKYCSMT 310
Query: 866 RC--------VHHGGSTFSCACLPGYA---GDGHQCTDVDECSE-NRCHPAATCYNTPGS 913
C H +C C PGY D C + D+C C C + PG
Sbjct: 311 LCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQK--CESRPGR 368
Query: 914 FSCRCQPGY 922
C C+ GY
Sbjct: 369 HLCHCEEGY 377
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/92 (30%), Positives = 38/92 (41%), Gaps = 8/92 (8%)
Query: 753 EDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFH 810
++S GN C D + C P C C G+ D + C D +EC
Sbjct: 1343 DESPLCNGNSCSDFNGGCTHECVQEP---FGAKCLCPLGFLLANDSKTCEDIDECDI-LG 1398
Query: 811 RCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
C + C N+ GS+RC C +GY D TC
Sbjct: 1399 SCSQH--CYNMRGSFRCSCDTGYMLESDGRTC 1428
Score = 39.7 bits (91), Expect = 0.020
Identities = 58/214 (27%), Positives = 69/214 (32%), Gaps = 59/214 (27%)
Query: 761 NPCYDGS---------HMCDTTA-RCHPGTGV------DYTCECASGYQGDG---RNCVD 801
N C DGS H C TA C G V DY +C G G R+C
Sbjct: 2723 NDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNA 2782
Query: 802 ENECATGFHRCGPNSVCINLPGSYRCE--------------CRSGYEFADDRHTCILITP 847
E RC P N G C C+SGY + + CI P
Sbjct: 2783 TTEFMCNNRRCIPREFICN--GVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICI---P 2837
Query: 848 PANPCEDGSHTC---APAGQARCVHH--GGSTFSCA---CLP--GYAGDGHQCTDVDECS 897
C DG + C + C H S F CA C+P Y C D +
Sbjct: 2838 RVYLC-DGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEP 2896
Query: 898 ENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIP 931
+ H TC F C DG +CIP
Sbjct: 2897 ASCGHSERTC--LADEFKC--------DGGRCIP 2920
Score = 36.2 bits (82), Expect = 0.22
Identities = 61/271 (22%), Positives = 83/271 (30%), Gaps = 69/271 (25%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C S CDT C + D + CAS G+ C +C ++ C +
Sbjct: 3606 CIPESWQCDTFNDCEDNSDED-SSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHS 3664
Query: 823 GSYRCECRSGYEFADD--------RHTCI---LITPPANPCEDGS-------HTCAPAGQ 864
EC S D+ + CI + + C D S TC P G
Sbjct: 3665 DEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
Query: 865 ARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSEN----RCHPAATCYNTPGSFSCRCQP 920
RC +H C+P QC ++C +N C P T F C Q
Sbjct: 3725 FRCKNH-------HCIP----LRWQCDGQNDCGDNSDEENCAPREC---TESEFRCVNQ- 3769
Query: 921 GYYGDGFQCIPD-----------STSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNF 969
QCIP S CE + H + G H
Sbjct: 3770 -------QCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVH---------- 3812
Query: 970 LPLQCHGSTGFCWCVDPDGHEVPGTQTPPGS 1000
L+C GS C+D T+ P G+
Sbjct: 3813 SELKCDGSAD---CLDASDEADCPTRFPDGA 3840
Score = 35.8 bits (81), Expect = 0.29
Identities = 34/137 (24%), Positives = 45/137 (32%), Gaps = 33/137 (24%)
Query: 804 ECATGFHRCGPNSVCINLPGSYRCE------------------CRSGYEFADDRHTCI-- 843
EC + RCG CI P +RC+ C+ GY CI
Sbjct: 27 ECDSAHFRCGSGH-CI--PADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPN 83
Query: 844 -LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRC- 901
+ C+DGS Q+ C H + + C+P H D EN C
Sbjct: 84 SWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ 143
Query: 902 HPA--------ATCYNT 910
+P CYNT
Sbjct: 144 YPTCEQLTCDNGACYNT 160
Score = 35.0 bits (79), Expect = 0.50
Identities = 55/236 (23%), Positives = 78/236 (33%), Gaps = 50/236 (21%)
Query: 763 CYDGSHMCDTTARCHPGTG-VDYTCECASGYQGDGRN--------CVDENECATGF--HR 811
CY+ S CD C + ++ T C G C +N+C G H
Sbjct: 157 CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHA 216
Query: 812 CGPNSVCINLP--GSYRCECRSG----YEFADDRHTCILITPPANPCEDGSHT---CAPA 862
C N P G Y+ C SG + D + CE G H C+P
Sbjct: 217 C-------NYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPR 269
Query: 863 G-----QARCVHHGGSTFSCACLPGYAGDGHQCT----DVDECSENRCHPAATCYNTPGS 913
RC+ PG + + T + CS C C+ TP
Sbjct: 270 EWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQ--YQCHETPYG 327
Query: 914 FSCRCQPGY---YGDGFQCIP-DSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDE 965
+C C PGY + D C+ D C+Q+ + PG H+ C+E
Sbjct: 328 GACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCE------SRPGR--HLCHCEE 375
Score = 32.0 bits (71), Expect = 4.2
Identities = 25/80 (31%), Positives = 29/80 (36%), Gaps = 24/80 (30%)
Query: 817 VCINLPGSYRCECRSGYEFADDRHT-C-ILITPPAN---PCEDGSHTCAPAGQARCVHHG 871
+C+ PG Y C C G F + T C I P N PC RC+H G
Sbjct: 4341 LCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPC-------------RCMHGG 4387
Query: 872 GSTF------SCACLPGYAG 885
F C C GY G
Sbjct: 4388 NCYFDETDLPKCKCPSGYTG 4407
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 124 bits (312), Expect = 5e-28
Identities = 74/230 (32%), Positives = 118/230 (51%), Gaps = 4/230 (1%)
Query: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
V +D+D +YW+D+A I R L E I+NSGL + E LA + + + +YW D
Sbjct: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
Query: 1205 SVLDKIESALLDGSERKVLFYTDLVN-PRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE 1263
+ KIE A DG R + + +++ PRA+ + P G ++WTDW P I S++DG
Sbjct: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGS 910
Query: 1264 NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVS 1323
L++ D+ PNG++ D + + W DA + +E G R VI +NL +P++I
Sbjct: 911 AAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAV 968
Query: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1373
+ + Y DW + + +K+SG E L Q + L + Y TG
Sbjct: 969 FKNEIYWDDWSQLSIFRASKYSGS-QMEILANQLTGLMDMKIFYKGKNTG 1017
Score = 38.9 bits (89), Expect = 0.034
Identities = 69/304 (22%), Positives = 102/304 (33%), Gaps = 68/304 (22%)
Query: 783 DYTCECASGYQGDGRNCV-DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
D C+C GYQ CV +EN C +RC N CIN + C+ + D
Sbjct: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCS-NGNCIN--SIWWCDFDNDCGDMSDERN 1111
Query: 842 CILITPPANPCE-DGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDG--------HQC-T 891
C P C+ D C +G C+ ++ C L GD HQC +
Sbjct: 1112 C-----PTTICDLDTQFRCQESG--TCI---PLSYKCD-LEDDCGDNSDESHCEMHQCRS 1160
Query: 892 DVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQY 951
D CS C + + G CR + D C T+ CE + +
Sbjct: 1161 DEYNCSSGMC--IRSSWVCDGDNDCR----DWSDEANC----TAIYHTCEASNFQCRNGH 1210
Query: 952 AYP--GARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQ-------TPPGSTP 1002
P A C + + P+ C C P+G +P ++ GS
Sbjct: 1211 CIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC--PNGTCIPSSKHCDGLRDCSDGSDE 1268
Query: 1003 PHCGPSPEPTQRPPTICERWRENLLEH-------------------YGGTPRDDQYVPQC 1043
HC P T +C+ R+ L H + G +D ++ C
Sbjct: 1269 QHC--EPLCTHFMDFVCKN-RQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVC 1325
Query: 1044 DDLG 1047
D+ G
Sbjct: 1326 DEFG 1329
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 120 bits (300), Expect = 1e-26
Identities = 104/375 (27%), Positives = 149/375 (39%), Gaps = 38/375 (10%)
Query: 566 YTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEE 625
+++I H+P + L W A E + NG SL G F + V F GE
Sbjct: 3245 HSSIRHVPANVGPLMRVLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFATGE- 3303
Query: 626 TVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDY 685
+ +TQ A GLDP+ L + + G VP A+ + ++E Y + S
Sbjct: 3304 LLTMTQVARGLDPDGLLLLDVVVNGVVPESLADADLQVQDFEEHYVQTGPGQLFVGSTQR 3363
Query: 686 SLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRF--- 742
G + R + +I Y +A R P Q L + + ++ E LRF
Sbjct: 3364 FFQGGLPS---FLRCNHSIQY----NAARGPQPQLVQHLRASAISSAFDPEAEALRFQLA 3416
Query: 743 ----AVTNQIGPVKEDSDPTPGNPCYD------GSHMCDTTARCHPGTGVDYTCECASGY 792
A N++G + + G C D G C PG ++C C +G+
Sbjct: 3417 TALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGR---FSCTCPTGF 3473
Query: 793 Q--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRC--ECRSGYEFADDRHTCILITPP 848
D RNC D +ECA H C C+NL GSYRC +C G+ AD
Sbjct: 3474 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG-----CED 3528
Query: 849 ANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAAT 906
+ C +G C C + G C+C GY G C DV+EC + A
Sbjct: 3529 VDECLEGLDDC--HYNQLCENTPGG-HRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ 3585
Query: 907 CYNTPGSFSCRCQPG 921
C+N GS+ C C PG
Sbjct: 3586 CHNLQGSYRCLCPPG 3600
Score = 58.5 bits (140), Expect = 4e-08
Identities = 54/216 (25%), Positives = 65/216 (30%), Gaps = 65/216 (30%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCIN 820
C +G C C G + C C GY QG C+D NEC C C N
Sbjct: 3532 CLEGLDDCHYNQLCENTPG-GHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 3588
Query: 821 LPGSYRCECRSGYEFADDR-------------------------------------HTCI 843
L GSYRC C G D H +
Sbjct: 3589 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3648
Query: 844 LITPPANPCEDGSHTCAPAGQAR----------------CVHHGGST---FSCACLPGYA 884
+ P P G R C H +T + C C GY
Sbjct: 3649 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYR 3708
Query: 885 --GDGHQCTDVDECSEN--RCHPAATCYNTPGSFSC 916
G C D++EC E C P C+NT GS+ C
Sbjct: 3709 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3744
Score = 52.0 bits (123), Expect = 4e-06
Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 768 HMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSY 825
++C R G+ Y C C +GY+ G+NC D NEC CGP +C N GSY
Sbjct: 3686 NLCQHACRNTEGS---YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSY 3742
Query: 826 RC---ECRSGYEFADDRHTC 842
+C C + Y TC
Sbjct: 3743 QCVDTPCPATYRQGPSPGTC 3762
Score = 38.5 bits (88), Expect = 0.045
Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)
Query: 879 CLPGYAGD--GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ D G C D DECS + C N PG FSC C G+
Sbjct: 3428 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGF 3473
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 120 bits (300), Expect = 1e-26
Identities = 104/375 (27%), Positives = 149/375 (39%), Gaps = 38/375 (10%)
Query: 566 YTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEE 625
+++I H+P + L W A E + NG SL G F + V F GE
Sbjct: 4436 HSSIRHVPANVGPLMRVLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFATGE- 4494
Query: 626 TVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDY 685
+ +TQ A GLDP+ L + + G VP A+ + ++E Y + S
Sbjct: 4495 LLTMTQVARGLDPDGLLLLDVVVNGVVPESLADADLQVQDFEEHYVQTGPGQLFVGSTQR 4554
Query: 686 SLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRF--- 742
G + R + +I Y +A R P Q L + + ++ E LRF
Sbjct: 4555 FFQGGLPS---FLRCNHSIQY----NAARGPQPQLVQHLRASAISSAFDPEAEALRFQLA 4607
Query: 743 ----AVTNQIGPVKEDSDPTPGNPCYD------GSHMCDTTARCHPGTGVDYTCECASGY 792
A N++G + + G C D G C PG ++C C +G+
Sbjct: 4608 TALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGR---FSCTCPTGF 4664
Query: 793 Q--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRC--ECRSGYEFADDRHTCILITPP 848
D RNC D +ECA H C C+NL GSYRC +C G+ AD
Sbjct: 4665 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG-----CED 4719
Query: 849 ANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAAT 906
+ C +G C C + G C+C GY G C DV+EC + A
Sbjct: 4720 VDECLEGLDDC--HYNQLCENTPGG-HRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ 4776
Query: 907 CYNTPGSFSCRCQPG 921
C+N GS+ C C PG
Sbjct: 4777 CHNLQGSYRCLCPPG 4791
Score = 58.5 bits (140), Expect = 4e-08
Identities = 54/216 (25%), Positives = 65/216 (30%), Gaps = 65/216 (30%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCIN 820
C +G C C G + C C GY QG C+D NEC C C N
Sbjct: 4723 CLEGLDDCHYNQLCENTPG-GHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 4779
Query: 821 LPGSYRCECRSGYEFADDR-------------------------------------HTCI 843
L GSYRC C G D H +
Sbjct: 4780 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 4839
Query: 844 LITPPANPCEDGSHTCAPAGQAR----------------CVHHGGST---FSCACLPGYA 884
+ P P G R C H +T + C C GY
Sbjct: 4840 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYR 4899
Query: 885 --GDGHQCTDVDECSEN--RCHPAATCYNTPGSFSC 916
G C D++EC E C P C+NT GS+ C
Sbjct: 4900 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 4935
Score = 52.0 bits (123), Expect = 4e-06
Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 768 HMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSY 825
++C R G+ Y C C +GY+ G+NC D NEC CGP +C N GSY
Sbjct: 4877 NLCQHACRNTEGS---YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSY 4933
Query: 826 RC---ECRSGYEFADDRHTC 842
+C C + Y TC
Sbjct: 4934 QCVDTPCPATYRQGPSPGTC 4953
Score = 38.5 bits (88), Expect = 0.045
Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)
Query: 879 CLPGYAGD--GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ D G C D DECS + C N PG FSC C G+
Sbjct: 4619 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGF 4664
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 120 bits (300), Expect = 1e-26
Identities = 104/375 (27%), Positives = 149/375 (39%), Gaps = 38/375 (10%)
Query: 566 YTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEE 625
+++I H+P + L W A E + NG SL G F + V F GE
Sbjct: 3154 HSSIRHVPANVGPLMRVLVVTIAPIYWALARESGEALNGHSLTGGRFRQESHVEFATGE- 3212
Query: 626 TVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDY 685
+ +TQ A GLDP+ L + + G VP A+ + ++E Y + S
Sbjct: 3213 LLTMTQVARGLDPDGLLLLDVVVNGVVPESLADADLQVQDFEEHYVQTGPGQLFVGSTQR 3272
Query: 686 SLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRF--- 742
G + R + +I Y +A R P Q L + + ++ E LRF
Sbjct: 3273 FFQGGLPS---FLRCNHSIQY----NAARGPQPQLVQHLRASAISSAFDPEAEALRFQLA 3325
Query: 743 ----AVTNQIGPVKEDSDPTPGNPCYD------GSHMCDTTARCHPGTGVDYTCECASGY 792
A N++G + + G C D G C PG ++C C +G+
Sbjct: 3326 TALQAEENEVGCPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGR---FSCTCPTGF 3382
Query: 793 Q--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRC--ECRSGYEFADDRHTCILITPP 848
D RNC D +ECA H C C+NL GSYRC +C G+ AD
Sbjct: 3383 ALAWDDRNCRDVDECAWDAHLCREGQRCVNLLGSYRCLPDCGPGFRVADGAG-----CED 3437
Query: 849 ANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAAT 906
+ C +G C C + G C+C GY G C DV+EC + A
Sbjct: 3438 VDECLEGLDDC--HYNQLCENTPGG-HRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ 3494
Query: 907 CYNTPGSFSCRCQPG 921
C+N GS+ C C PG
Sbjct: 3495 CHNLQGSYRCLCPPG 3509
Score = 58.5 bits (140), Expect = 4e-08
Identities = 54/216 (25%), Positives = 65/216 (30%), Gaps = 65/216 (30%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCIN 820
C +G C C G + C C GY QG C+D NEC C C N
Sbjct: 3441 CLEGLDDCHYNQLCENTPG-GHRCSCPRGYRMQGPSLPCLDVNECLQLPKACAYQ--CHN 3497
Query: 821 LPGSYRCECRSGYEFADDR-------------------------------------HTCI 843
L GSYRC C G D H +
Sbjct: 3498 LQGSYRCLCPPGQTLLRDGKACTSLERNGQNVTTVSHRGPLLPWLRPWASIPGTSYHAWV 3557
Query: 844 LITPPANPCEDGSHTCAPAGQAR----------------CVHHGGST---FSCACLPGYA 884
+ P P G R C H +T + C C GY
Sbjct: 3558 SLRPGPMALSSVGRAWCPPGFIRQNGVCTDLDECRVRNLCQHACRNTEGSYQCLCPAGYR 3617
Query: 885 --GDGHQCTDVDECSEN--RCHPAATCYNTPGSFSC 916
G C D++EC E C P C+NT GS+ C
Sbjct: 3618 LLPSGKNCQDINECEEESIECGPGQMCFNTRGSYQC 3653
Score = 52.0 bits (123), Expect = 4e-06
Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 8/80 (10%)
Query: 768 HMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSY 825
++C R G+ Y C C +GY+ G+NC D NEC CGP +C N GSY
Sbjct: 3595 NLCQHACRNTEGS---YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFNTRGSY 3651
Query: 826 RC---ECRSGYEFADDRHTC 842
+C C + Y TC
Sbjct: 3652 QCVDTPCPATYRQGPSPGTC 3671
Score = 38.5 bits (88), Expect = 0.045
Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 2/46 (4%)
Query: 879 CLPGYAGD--GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ D G C D DECS + C N PG FSC C G+
Sbjct: 3337 CPEGFELDSQGAFCVDRDECSGGPSPCSHACLNAPGRFSCTCPTGF 3382
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 119 bits (299), Expect = 2e-26
Identities = 67/171 (39%), Positives = 85/171 (49%), Gaps = 14/171 (8%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECATGFHRCGPNSVCIN 820
C + +CD C G + C C G+ D R CVD +EC H C + C N
Sbjct: 1200 CEENPRVCDQ-GHCTNMPG-GHRCLCYDGFMATPDMRTCVDVDECDLNPHIC-LHGDCEN 1256
Query: 821 LPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACL 880
GS+ C C+ GY C + CE G H C A C++ GS FSC CL
Sbjct: 1257 TKGSFVCHCQLGYMVRKGATGC----SDVDECEVGGHNCD--SHASCLNIPGS-FSCRCL 1309
Query: 881 PGYAGDGHQCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQC 929
PG+ GDG +C D+DEC E+RC P C N PGS+ C C+ G+ GDGF C
Sbjct: 1310 PGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC 1360
Score = 115 bits (289), Expect = 2e-25
Identities = 61/166 (36%), Positives = 79/166 (47%), Gaps = 21/166 (12%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C G H CD+ A C G ++C C G+ GDG C D +EC + HRC P C+N+P
Sbjct: 1284 CEVGGHNCDSHASCLNIPG-SFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVP 1342
Query: 823 GSYRCECRSGYE----FADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
GSYRC CR G+ F +DR C + C++G AP G + C
Sbjct: 1343 GSYRCTCRQGFAGDGFFCEDRDEC---AENVDLCDNGQCLNAPGG-----------YRCE 1388
Query: 879 CLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ D C DVDEC++ +C N PG F C C GY
Sbjct: 1389 CEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNGGY 1434
Score = 108 bits (269), Expect = 5e-23
Identities = 60/152 (39%), Positives = 74/152 (48%), Gaps = 15/152 (9%)
Query: 784 YTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
Y C C GY DGR C D +EC C C N+PG +RC C G+ D T
Sbjct: 1177 YRCSCGQGYSLMPDGRACADVDECEENPRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRT 1235
Query: 842 CILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDECSE- 898
C+ + + C+ H C C + GS F C C GY C+DVDEC
Sbjct: 1236 CVDV----DECDLNPHICL---HGDCENTKGS-FVCHCQLGYMVRKGATGCSDVDECEVG 1287
Query: 899 -NRCHPAATCYNTPGSFSCRCQPGYYGDGFQC 929
+ C A+C N PGSFSCRC PG+ GDGF+C
Sbjct: 1288 GHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
Score = 94.0 bits (232), Expect = 9e-19
Identities = 56/163 (34%), Positives = 78/163 (47%), Gaps = 16/163 (9%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN-CVDENECATGFHRCGPNSVCINL 821
C +++C RC P T Y CEC GY D R C+D +EC + G C+N+
Sbjct: 412 CRHFTNLC-LNGRCLP-TPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD---CVNI 466
Query: 822 PGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLP 881
PG+Y C C G++ R C+ + + C C RCV+ GS F C C
Sbjct: 467 PGTYHCRCYPGFQATPTRQACVDV----DECIVSGGLCH---LGRCVNTEGS-FQCVCNA 518
Query: 882 GY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
G+ + DG C D +EC+ + C N GSFSC C+PG+
Sbjct: 519 GFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGF 561
Score = 93.6 bits (231), Expect = 1e-18
Identities = 64/184 (34%), Positives = 82/184 (44%), Gaps = 29/184 (15%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY----QGDGRNCVDENECATGF 809
D D PC +G+ C G Y C C G+ GD CVD +EC T
Sbjct: 1847 DIDECDRQPCGNGT--------CKNIIG-SYNCLCFPGFVVTHNGD---CVDFDECTTLV 1894
Query: 810 HRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVH 869
+ C+N GS+ C C+ G+E D C+ N C + TC P C +
Sbjct: 1895 GQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCV----DTNECLSLAGTCLPG---TCQN 1947
Query: 870 HGGSTFSCACLPGYAGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY--GD 925
GS F C C PG+ C D+DECSE N C TC N+PGSF C C PG+ +
Sbjct: 1948 LEGS-FRCICPPGFQVQSDHCIDIDECSEEPNLC-LFGTCTNSPGSFQCLCPPGFVLSDN 2005
Query: 926 GFQC 929
G +C
Sbjct: 2006 GHRC 2009
Score = 92.4 bits (228), Expect = 3e-18
Identities = 58/179 (32%), Positives = 80/179 (44%), Gaps = 24/179 (13%)
Query: 763 CYDGSHMCDTTARCHPGTGVD----YTCECASGYQ--GDGRNCVDENECATGFHRCGPNS 816
C D C GT + Y C+C G++ G C D +EC+ C P+
Sbjct: 1069 CMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLC-PHG 1127
Query: 817 VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFS 876
C+N+ G+++C C +G++ DR C+ I N C + C C++ GS +
Sbjct: 1128 QCVNVIGAFQCSCHAGFQSTPDRQGCVDI----NECRVQNGGC----DVHCINTEGS-YR 1178
Query: 877 CACLPGYA--GDGHQCTDVDECSEN-RCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPD 932
C+C GY+ DG C DVDEC EN R C N PG C C DGF PD
Sbjct: 1179 CSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCY-----DGFMATPD 1232
Score = 90.1 bits (222), Expect = 1e-17
Identities = 58/169 (34%), Positives = 76/169 (44%), Gaps = 20/169 (11%)
Query: 772 TTARCHPGTGVD----YTCECASGYQGDGRN--CVDENECATGFHRCGPNSVCINLPGSY 825
T++ CH G V+ Y C C G+Q CVD +EC C C+N GS+
Sbjct: 454 TSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR-CVNTEGSF 512
Query: 826 RCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY-- 883
+C C +G+E + D C+ N C T C++ GS FSC C PG+
Sbjct: 513 QCVCNAGFELSPDGKNCV----DHNECA----TSTMCVNGVCLNEDGS-FSCLCKPGFLL 563
Query: 884 AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCI 930
A GH C D+DEC C NT GSF C+C G DG C+
Sbjct: 564 APGGHYCMDIDECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCV 612
Score = 89.7 bits (221), Expect = 2e-17
Identities = 65/211 (30%), Positives = 90/211 (42%), Gaps = 26/211 (12%)
Query: 743 AVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVD----YTCECASGYQGD--G 796
A ++ P + P P + D + + C G V+ + CEC GY D G
Sbjct: 2062 AAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTG 2121
Query: 797 RNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGS 856
NCVD +EC+ G H CG C N+ G + C C G+E ++ + C
Sbjct: 2122 INCVDTDECSVG-HPCG-QGTCTNVIGGFECACADGFE-----PGLMMTCEDIDECSLNP 2174
Query: 857 HTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDECSENR--CHP-AATCYNTP 911
CA RC H+ ++ C C GY DG C DVDEC++ + CH C N
Sbjct: 2175 LLCA----FRC-HNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLI 2229
Query: 912 GSFSCRCQPGYY---GDGFQCIPDSTSSLTP 939
G+F+C C PG G G C D+ P
Sbjct: 2230 GTFACVCPPGMRPLPGSGEGCTDDNECHAQP 2260
Score = 88.2 bits (217), Expect = 5e-17
Identities = 55/165 (33%), Positives = 73/165 (44%), Gaps = 19/165 (11%)
Query: 784 YTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
+TC C G+ + C D +EC+ CG + C N PGS+RCEC G+ H C
Sbjct: 2468 FTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGC- 2526
Query: 844 LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGH--QCTDVDEC--SEN 899
N C DG H C Q C + G + C+C G+ QC D +EC S
Sbjct: 2527 ---EDVNEC-DGPHRC----QHGCQNQLGG-YRCSCPQGFTQHSQWAQCVDENECALSPP 2577
Query: 900 RCHPAATCYNTPGSFSCRCQPGYYGD----GFQCIPDSTSSLTPC 940
C +A+C NT G F C C G+ D G Q + + PC
Sbjct: 2578 TC-GSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPC 2621
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/143 (33%), Positives = 70/143 (48%), Gaps = 14/143 (9%)
Query: 784 YTCECASGYQGDG--RNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
+ CEC +G+ + C D +EC + C N+ CIN+PGSYRC+C GY+ +
Sbjct: 1744 FRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPG-GA 1802
Query: 842 CILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQ--CTDVDECSEN 899
C+ N C + + C+ C+ GS + C C G+ Q C D+DEC
Sbjct: 1803 CV----GRNECREIPNVCS---HGDCMDTEGS-YMCLCHRGFQASADQTLCMDIDECDRQ 1854
Query: 900 RCHPAATCYNTPGSFSCRCQPGY 922
C TC N GS++C C PG+
Sbjct: 1855 PC-GNGTCKNIIGSYNCLCFPGF 1876
Score = 84.7 bits (208), Expect = 5e-16
Identities = 56/165 (33%), Positives = 74/165 (44%), Gaps = 16/165 (9%)
Query: 778 PGTGV-DYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFA 836
PGT C SGY +GR D +EC H C + CIN GS+RC C++GY
Sbjct: 2342 PGTSAYRKLCPHGSGYTAEGR---DVDECRMLAHLCA-HGECINSLGSFRCHCQAGYTPD 2397
Query: 837 DDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVD 894
TC+ + C C C + GS F C+C GY DG C D+D
Sbjct: 2398 ATATTCL----DMDECSQVPKPCT----FLCKNTKGS-FLCSCPRGYLLEEDGRTCKDLD 2448
Query: 895 ECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTP 939
EC+ + + C NT G+F+CRC PG+ C + S P
Sbjct: 2449 ECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493
Score = 82.8 bits (203), Expect = 2e-15
Identities = 58/185 (31%), Positives = 77/185 (41%), Gaps = 27/185 (14%)
Query: 760 GNPCYDGSHMCD------TTARCHPGTGVDYTCECASGYQGDG--RNCVDENECATGFHR 811
G P Y + C T C G + C CA G+ D RNC D +EC
Sbjct: 980 GRPFYKDVNECKVFPGLCTHGTCRNTVG-SFHCACAGGFALDAQERNCTDIDECRISPDL 1038
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
CG + C+N PGS+ CEC GYE + ++ ++ + C +
Sbjct: 1039 CGQGT-CVNTPGSFECECFPGYE------SGFMLMKNCMDVDECARDPLLCRGGTCTNTD 1091
Query: 872 GSTFSCACLPGY--AGDGHQCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGF 927
GS + C C PG+ G C D+DEC S+ C P C N G+F C C GF
Sbjct: 1092 GS-YKCQCPPGHELTAKGTACEDIDECSLSDGLC-PHGQCVNVIGAFQCSCHA-----GF 1144
Query: 928 QCIPD 932
Q PD
Sbjct: 1145 QSTPD 1149
Score = 82.4 bits (202), Expect = 3e-15
Identities = 66/203 (32%), Positives = 81/203 (39%), Gaps = 43/203 (21%)
Query: 801 DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCA 860
D NECA C N VC+N GS+RCEC GY C+ + C G
Sbjct: 2084 DVNECAENPGVC-TNGVCVNTDGSFRCECPFGYSLDFTGINCV----DTDECSVGH---- 2134
Query: 861 PAGQARCVHHGGSTFSCACLPGYA-GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQ 919
P GQ C + G F CAC G+ G C D+DECS N A C+NT GS+ C C
Sbjct: 2135 PCGQGTCTNVIGG-FECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCP 2193
Query: 920 PGY--YGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGS 977
GY DG C + C Q+ C +G ++C
Sbjct: 2194 AGYTLREDGAMC-----RDVDECADGQQ----------------DCHARG----MECKNL 2228
Query: 978 TGFCWCVDPDGHEVPGTQTPPGS 1000
G CV P PG + PGS
Sbjct: 2229 IGTFACVCP-----PGMRPLPGS 2246
Score = 81.3 bits (199), Expect = 6e-15
Identities = 66/201 (32%), Positives = 82/201 (40%), Gaps = 32/201 (15%)
Query: 786 CECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILI 845
C G DGR D NECA C N VC NL GSYRC C GYE C
Sbjct: 670 CSSGLGITTDGR---DINECALDPEVCA-NGVCENLRGSYRCVCNLGYEAGASGKDC--- 722
Query: 846 TPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDECSENRCHP 903
+ C S C C + GS +SC+C PG+ D C DVDEC + C
Sbjct: 723 -TDVDECALNSLLC---DNGWCQNSPGS-YSCSCPPGFHFWQDTEICKDVDECLSSPC-V 776
Query: 904 AATCYNTPGSFSCRCQPGYYGD--GFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIP 961
+ C N GS++C+C PG D G C+ DST + Q+ +
Sbjct: 777 SGVCRNLAGSYTCKCGPGSRLDPSGTFCL-DSTKGTCWLKIQESRCEVNL---------- 825
Query: 962 QCDEQGNFLPLQCHGSTGFCW 982
QG L +C + G W
Sbjct: 826 ----QGASLRSECCATLGAAW 842
Score = 77.4 bits (189), Expect = 9e-14
Identities = 60/196 (30%), Positives = 75/196 (38%), Gaps = 30/196 (15%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVD----YTCECASGYQG--DGRNCVDENECATGFHR 811
+PG C + + C G +D Y C C G+Q D C+D +EC
Sbjct: 1798 SPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDR--QP 1855
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQA----RC 867
CG N C N+ GSY C C G+ + C D GQ C
Sbjct: 1856 CG-NGTCKNIIGSYNCLCFPGF-----------VVTHNGDCVDFDECTTLVGQVCRFGHC 1903
Query: 868 VHHGGSTFSCACLPGY--AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY 923
++ GS F C C G+ DG C D +EC C P TC N GSF C C PG+
Sbjct: 1904 LNTAGS-FHCLCQDGFELTADGKNCVDTNECLSLAGTCLPG-TCQNLEGSFRCICPPGFQ 1961
Query: 924 GDGFQCIPDSTSSLTP 939
CI S P
Sbjct: 1962 VQSDHCIDIDECSEEP 1977
Score = 71.6 bits (174), Expect = 5e-12
Identities = 65/200 (32%), Positives = 78/200 (39%), Gaps = 51/200 (25%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGD--GRNCVDENECATGFHRCGPNSV 817
GN C GS C+ PG + C C GY+ D G NC D NECA + N V
Sbjct: 1411 GNLCAFGS--CENL----PGM---FRCICNGGYELDRGGGNCTDINECADPVNCI--NGV 1459
Query: 818 CINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARC---VHHGGST 874
CIN PGSY C C +E C + A C +H +G C + G +
Sbjct: 1460 CINTPGSYLCSCPQDFELNPSGVGC--VDTRAGNCFLETHDRGDSG-ISCSAEIGVGVTR 1516
Query: 875 FSCACLPGYA----------------------GDGHQ-------CTDVDECSE--NRCHP 903
SC C G A G+G Q D+DEC E C
Sbjct: 1517 ASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQ- 1575
Query: 904 AATCYNTPGSFSCRCQPGYY 923
C NT GSF C C PGY+
Sbjct: 1576 GGDCVNTFGSFQCECPPGYH 1595
Score = 69.3 bits (168), Expect = 2e-11
Identities = 59/190 (31%), Positives = 73/190 (38%), Gaps = 30/190 (15%)
Query: 763 CYDGSHMCDTTA-RCHPGTGVDYTCECASGYQ---GDGRNCVDENECATGFHRCGPNSVC 818
C DG C C G + C C G + G G C D+NEC C N C
Sbjct: 2211 CADGQQDCHARGMECKNLIGT-FACVCPPGMRPLPGSGEGCTDDNECHAQPDLC-VNGRC 2268
Query: 819 INLPGSYRCECRSGY-------EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
+N GS+RC+C G+ E D R C S + +A C G
Sbjct: 2269 VNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGG 2328
Query: 872 GSTFSCAC----LPGYA--------GDGH--QCTDVDECSENRCHPAA--TCYNTPGSFS 915
G + C LPG + G G+ + DVDEC H A C N+ GSF
Sbjct: 2329 GRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDEC-RMLAHLCAHGECINSLGSFR 2387
Query: 916 CRCQPGYYGD 925
C CQ GY D
Sbjct: 2388 CHCQAGYTPD 2397
Score = 66.2 bits (160), Expect = 2e-10
Identities = 63/197 (31%), Positives = 75/197 (38%), Gaps = 43/197 (21%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGD--GRNCVDENECATGFHRCGPNSVC 818
N C +C RC T + CEC G D GR CVD F R +
Sbjct: 871 NECESFPGVCPN-GRC-VNTAGSFRCECPEGLMLDASGRLCVDVR-LEPCFLRWDEDECG 927
Query: 819 INLPGSYR---CECRSGYEFADDRHTC----------------------ILITPP----A 849
+ LPG YR C C G + + C L P
Sbjct: 928 VTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDV 987
Query: 850 NPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQ--CTDVDEC--SENRCHPAA 905
N C+ C C + GS F CAC G+A D + CTD+DEC S + C
Sbjct: 988 NECKVFPGLCT---HGTCRNTVGS-FHCACAGGFALDAQERNCTDIDECRISPDLCGQG- 1042
Query: 906 TCYNTPGSFSCRCQPGY 922
TC NTPGSF C C PGY
Sbjct: 1043 TCVNTPGSFECECFPGY 1059
Score = 61.6 bits (148), Expect = 5e-09
Identities = 45/146 (30%), Positives = 64/146 (43%), Gaps = 14/146 (9%)
Query: 800 VDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTC 859
+D +EC C N +CIN GS+RCEC +G+ + ++ +L + C GS
Sbjct: 1720 LDIDECGEIPAICA-NGICINQIGSFRCECPAGFNY----NSILLACEDVDEC--GSRES 1772
Query: 860 APAGQARCVHHGGSTFSCACLPGY-AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSC 916
A C++ GS + C C GY G C +EC E N C C +T GS+ C
Sbjct: 1773 PCQQNADCINIPGS-YRCKCTRGYKLSPGGACVGRNECREIPNVC-SHGDCMDTEGSYMC 1830
Query: 917 RCQPGYYGDGFQ--CIPDSTSSLTPC 940
C G+ Q C+ PC
Sbjct: 1831 LCHRGFQASADQTLCMDIDECDRQPC 1856
Score = 48.1 bits (113), Expect = 6e-05
Identities = 62/241 (25%), Positives = 84/241 (34%), Gaps = 48/241 (19%)
Query: 779 GTGVDYTCECASGYQG-------------DGRNCVDENECATGFHRCGPNSVCINLPGSY 825
GT +C C GY G +G C+ N CA + GP C +
Sbjct: 128 GTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQ--CERDYRTG 185
Query: 826 RCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAG 885
C + G E + T ++ T G P H C G+
Sbjct: 186 PCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPH-------PCRRGFIP 238
Query: 886 DGHQ--CTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCE 941
+ H C DVDEC C +C N GSF CRC G+ + DS+++ CE
Sbjct: 239 NIHTGACQDVDECQAVPGLCQ-GGSCVNMVGSFHCRCPVGHR------LSDSSAA---CE 288
Query: 942 QQQRHAQAQYAYPGARFHIPQC--DEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPG 999
+ A + G +C D G++ QC G CW P VP P G
Sbjct: 289 DYRAGACFSVLFGG------RCAGDLAGHYTRRQCCCDRGRCWAAGP----VPELCPPRG 338
Query: 1000 S 1000
S
Sbjct: 339 S 339
Score = 40.4 bits (93), Expect = 0.012
Identities = 41/157 (26%), Positives = 58/157 (36%), Gaps = 28/157 (17%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCV-----DENECATGFHRCGP 814
GNPC C +Y C G +G N + D +EC C
Sbjct: 1528 GNPC----------ELCPMANTTEYRTLCPGG-EGFQPNRITVILEDIDECQELPGLCQG 1576
Query: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
C+N GS++CEC GY ++ C + C S C P C + G+
Sbjct: 1577 GD-CVNTFGSFQCECPPGYHLSEHTRIC----EDIDECSTHSGICGP---GTCYNTLGN- 1627
Query: 875 FSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYN 909
++C C Y G+ C D+ + R H TC N
Sbjct: 1628 YTCVCPAEYLQVNGGNNCMDMRKSVCFR-HYNGTCQN 1663
Score = 38.9 bits (89), Expect = 0.034
Identities = 33/126 (26%), Positives = 38/126 (30%), Gaps = 46/126 (36%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVD---YTCECASGYQGDGR--NCVDENECATGFHRCGP 814
G+ C D + CD RC G Y C C G+ + CVDENECA CG
Sbjct: 2523 GHGCEDVNE-CDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGS 2581
Query: 815 NSV----------------------------------------CINLPGSYRCECRSGYE 834
S C N PG + C C GY
Sbjct: 2582 ASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYF 2641
Query: 835 FADDRH 840
A H
Sbjct: 2642 RAGQGH 2647
Score = 34.3 bits (77), Expect = 0.85
Identities = 41/150 (27%), Positives = 54/150 (36%), Gaps = 20/150 (13%)
Query: 861 PAGQARCVHHGGSTFSCACL-PGYAGDG----HQCTDVDECSENRCHPAATCYNTPGSFS 915
P G AR HG L PG + G +Q D+ N C C TP S+
Sbjct: 374 PLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGR-CLPTPSSYR 432
Query: 916 CRCQPGYYGD-GFQCIPDSTSSLTPCEQQQ-RHAQAQY---AYPG--------ARFHIPQ 962
C C GY D +CI + +PC + Y YPG A + +
Sbjct: 433 CECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDE 492
Query: 963 CDEQGNFLPL-QCHGSTGFCWCVDPDGHEV 991
C G L +C + G CV G E+
Sbjct: 493 CIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
Score = 31.6 bits (70), Expect = 5.5
Identities = 12/38 (31%), Positives = 16/38 (42%)
Query: 486 ETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 523
+ CE C HA C + F C C + G+G C
Sbjct: 1282 DECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 119 bits (299), Expect = 2e-26
Identities = 71/188 (37%), Positives = 91/188 (48%), Gaps = 28/188 (14%)
Query: 759 PGNPCYDGSHMCDTTARCHPG-----TGVDYTCE-----CASGYQG--DGRNCVDENECA 806
P C D + + C PG T YTC+ CA GY DG CVD NEC
Sbjct: 804 PEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECE 863
Query: 807 TGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPP-ANPCEDGSHTCAPAGQA 865
TG HRCG VC NLPGSYRC+C++G++ CI + A+P HTC
Sbjct: 864 TGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTC------ 917
Query: 866 RCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY 923
+ ++ C+C G+ A DG +C DV+EC RC + C N GS+ C C+ GY
Sbjct: 918 ---ENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC--SQECANIYGSYQCYCRQGYQ 972
Query: 924 --GDGFQC 929
DG C
Sbjct: 973 LAEDGHTC 980
Score = 91.3 bits (225), Expect = 6e-18
Identities = 60/184 (32%), Positives = 79/184 (42%), Gaps = 26/184 (14%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTC----ECASGYQGDGRNCVDENECATGFHRCGPNS 816
N C H C C G + C C GY C D +ECA G H C P
Sbjct: 721 NECVTDLHTCSRGEHCVNTLG-SFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGF 779
Query: 817 VCINLPGSYRCE----CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
+C N GS+ C+ C G+ D C+ I N C S C P C++ G
Sbjct: 780 LCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDI----NECTSLSEPCRPG--FSCINTVG 832
Query: 873 STFSC-----ACLPGY--AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY 923
S ++C C GY + DG +C DV+EC +RC C+N PGS+ C C+ G+
Sbjct: 833 S-YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 891
Query: 924 GDGF 927
D F
Sbjct: 892 RDAF 895
Score = 90.1 bits (222), Expect = 1e-17
Identities = 64/213 (30%), Positives = 89/213 (41%), Gaps = 40/213 (18%)
Query: 743 AVTNQIGPVKEDSDPTP---GNPCYDGS---HMCDTTARCHPGTGVDYTCECASGY--QG 794
A+ ++ V ++ P P N C D +C T G C C GY
Sbjct: 660 ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTV-------GGSAICSCFPGYAIMA 712
Query: 795 DGRNCVDENECATGFHRCGPNSVCINLPGSYRC----ECRSGYEFADDRHTCILITPPAN 850
DG +C D NEC T H C C+N GS+ C C GY D +
Sbjct: 713 DGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE------CEDVD 766
Query: 851 PCEDGSHTCAPAGQARCVHHGGSTFSCA---CLPGYAGDGH-QCTDVDECS--ENRCHPA 904
C G+HTC P C + GS + A C+ G+ D C D++EC+ C P
Sbjct: 767 ECAMGTHTCQPG--FLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPG 824
Query: 905 ATCYNTPGSFSCR-----CQPGYYG--DGFQCI 930
+C NT GS++C+ C GY+ DG +C+
Sbjct: 825 FSCINTVGSYTCQRNPLICARGYHASDDGTKCV 857
Score = 77.8 bits (190), Expect = 7e-14
Identities = 60/198 (30%), Positives = 76/198 (38%), Gaps = 66/198 (33%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPN 815
+PG C H C+ T Y C CASG+ DG+ C D NEC RC
Sbjct: 908 SPGRLC---QHTCENTLG-------SYRCSCASGFLLAADGKRCEDVNECEA--QRCSQE 955
Query: 816 SVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTF 875
C N+ GSY+C CR GY+ A+D HTC I + C G+ RC++ GS +
Sbjct: 956 --CANIYGSYQCYCRQGYQLAEDGHTCTDI----DECAQGAGILCTF---RCLNVPGS-Y 1005
Query: 876 SCACLP-GYA--GDGHQCTDVDECS----------------------------------- 897
CAC GY +G C DVDEC+
Sbjct: 1006 QCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSK 1065
Query: 898 ----ENRCHPAATCYNTP 911
CH C N+P
Sbjct: 1066 TKCERTTCHDFLECQNSP 1083
Score = 67.8 bits (164), Expect = 7e-11
Identities = 48/143 (33%), Positives = 56/143 (39%), Gaps = 43/143 (30%)
Query: 817 VCINLPGSYRCECRSGYEFADDRHTC-----------------------------ILITP 847
+CIN GSY C C G+ DD TC L P
Sbjct: 619 LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678
Query: 848 PANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDEC--SENRCHP 903
N C+D P Q C GGS C+C PGYA DG C D++EC + C
Sbjct: 679 QPNTCKDN----GPCKQV-CSTVGGSAI-CSCFPGYAIMADGVSCEDINECVTDLHTCSR 732
Query: 904 AATCYNTPGSFSC----RCQPGY 922
C NT GSF C C+PGY
Sbjct: 733 GEHCVNTLGSFHCYKALTCEPGY 755
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 119 bits (299), Expect = 2e-26
Identities = 71/188 (37%), Positives = 91/188 (48%), Gaps = 28/188 (14%)
Query: 759 PGNPCYDGSHMCDTTARCHPG-----TGVDYTCE-----CASGYQG--DGRNCVDENECA 806
P C D + + C PG T YTC+ CA GY DG CVD NEC
Sbjct: 851 PEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECE 910
Query: 807 TGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPP-ANPCEDGSHTCAPAGQA 865
TG HRCG VC NLPGSYRC+C++G++ CI + A+P HTC
Sbjct: 911 TGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTC------ 964
Query: 866 RCVHHGGSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY 923
+ ++ C+C G+ A DG +C DV+EC RC + C N GS+ C C+ GY
Sbjct: 965 ---ENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRC--SQECANIYGSYQCYCRQGYQ 1019
Query: 924 --GDGFQC 929
DG C
Sbjct: 1020 LAEDGHTC 1027
Score = 93.2 bits (230), Expect = 2e-18
Identities = 62/190 (32%), Positives = 84/190 (44%), Gaps = 30/190 (15%)
Query: 763 CYDGSHMCDTTARCHPGTG----VDYTCECASGYQGDG-RNCVDENECATGFHRCGPNSV 817
C G+H C C G V++T CA GY + R CVD NEC T H C
Sbjct: 723 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH 782
Query: 818 CINLPGSYRC----ECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGS 873
C+N GS+ C C GY D + C G+HTC P C + GS
Sbjct: 783 CVNTLGSFHCYKALTCEPGYALKDGE------CEDVDECAMGTHTCQPG--FLCQNTKGS 834
Query: 874 TFSCA---CLPGYAGDGH-QCTDVDECS--ENRCHPAATCYNTPGSFSCR-----CQPGY 922
+ A C+ G+ D C D++EC+ C P +C NT GS++C+ C GY
Sbjct: 835 FYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGY 894
Query: 923 YG--DGFQCI 930
+ DG +C+
Sbjct: 895 HASDDGTKCV 904
Score = 92.8 bits (229), Expect = 2e-18
Identities = 73/224 (32%), Positives = 93/224 (41%), Gaps = 41/224 (18%)
Query: 743 AVTNQIGPVKEDSDPTP---GNPCYDGS---HMCDTTARCHPGTGVDYTCECASGY--QG 794
A+ ++ V ++ P P N C D +C T G C C GY
Sbjct: 660 ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTV-------GGSAICSCFPGYAIMA 712
Query: 795 DGRNCVDENECATGFHRCGPNSVCINLPGSYRCE-----CRSGYEFADDRHTCILITPPA 849
DG +C D++EC G H C C+N GS+ C C GY + C+ I
Sbjct: 713 DGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGY-ILNAHRKCVDI---- 767
Query: 850 NPCEDGSHTCAPAGQARCVHHGGSTFSC----ACLPGYAGDGHQCTDVDECS--ENRCHP 903
N C HTC+ CV+ GS F C C PGYA +C DVDEC+ + C P
Sbjct: 768 NECVTDLHTCSRG--EHCVNTLGS-FHCYKALTCEPGYALKDGECEDVDECAMGTHTCQP 824
Query: 904 AATCYNTPGSFSC----RCQPGYYGD---GFQCIPDSTSSLTPC 940
C NT GSF C RC G+ D I + TS PC
Sbjct: 825 GFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPC 868
Score = 91.3 bits (225), Expect = 6e-18
Identities = 60/184 (32%), Positives = 79/184 (42%), Gaps = 26/184 (14%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTC----ECASGYQGDGRNCVDENECATGFHRCGPNS 816
N C H C C G + C C GY C D +ECA G H C P
Sbjct: 768 NECVTDLHTCSRGEHCVNTLG-SFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGF 826
Query: 817 VCINLPGSYRCE----CRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
+C N GS+ C+ C G+ D C+ I N C S C P C++ G
Sbjct: 827 LCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDI----NECTSLSEPCRPG--FSCINTVG 879
Query: 873 STFSC-----ACLPGY--AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY 923
S ++C C GY + DG +C DV+EC +RC C+N PGS+ C C+ G+
Sbjct: 880 S-YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 938
Query: 924 GDGF 927
D F
Sbjct: 939 RDAF 942
Score = 77.8 bits (190), Expect = 7e-14
Identities = 60/198 (30%), Positives = 76/198 (38%), Gaps = 66/198 (33%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPN 815
+PG C H C+ T Y C CASG+ DG+ C D NEC RC
Sbjct: 955 SPGRLC---QHTCENTLG-------SYRCSCASGFLLAADGKRCEDVNECEA--QRCSQE 1002
Query: 816 SVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTF 875
C N+ GSY+C CR GY+ A+D HTC I + C G+ RC++ GS +
Sbjct: 1003 --CANIYGSYQCYCRQGYQLAEDGHTCTDI----DECAQGAGILCTF---RCLNVPGS-Y 1052
Query: 876 SCACLP-GYA--GDGHQCTDVDECS----------------------------------- 897
CAC GY +G C DVDEC+
Sbjct: 1053 QCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSK 1112
Query: 898 ----ENRCHPAATCYNTP 911
CH C N+P
Sbjct: 1113 TKCERTTCHDFLECQNSP 1130
Score = 62.4 bits (150), Expect = 3e-09
Identities = 48/144 (33%), Positives = 53/144 (36%), Gaps = 44/144 (30%)
Query: 817 VCINLPGSYRCECRSGYEFADDRHTC-----------------------------ILITP 847
+CIN GSY C C G+ DD TC L P
Sbjct: 619 LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLP 678
Query: 848 PANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDEC--SENRCHP 903
N C+D P Q C GGS C+C PGYA DG C D DEC + C
Sbjct: 679 QPNTCKDN----GPCKQV-CSTVGGSAI-CSCFPGYAIMADGVSCEDQDECLMGAHDCSR 732
Query: 904 AATCYNTPGSFSC-----RCQPGY 922
C NT GSF C C GY
Sbjct: 733 RQFCVNTLGSFYCVNHTVLCADGY 756
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 117 bits (293), Expect = 8e-26
Identities = 81/281 (28%), Positives = 115/281 (40%), Gaps = 63/281 (22%)
Query: 770 CDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRC 827
CDT G+ Y C C+ GY DGR+C D +EC C C N+PG YRC
Sbjct: 1253 CDTQCTNSEGS---YECSCSEGYALMPDGRSCADIDECENNPDICDGGQ-CTNIPGEYRC 1308
Query: 828 ECRSGYEFADDRHTCILIT--------------------------------------PPA 849
C G+ + D TCI +
Sbjct: 1309 LCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDV 1368
Query: 850 NPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSE--NRCHPAATC 907
+ CE G+H C A C++ GS F C+C G+ G+G +C D+DECS ++C A C
Sbjct: 1369 DECEIGAHNCDM--HASCLNIPGS-FKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQC 1425
Query: 908 YNTPGSFSCRCQPGYYGDGFQC--IPDSTSSLTPCEQQQ-------RHAQAQYAYPGAR- 957
NTPGS+ C C G+ GDGF C + + ++ CE Q + + + A
Sbjct: 1426 VNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASD 1485
Query: 958 ----FHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGT 994
I +C Q + C+ G C+ DG+E+ T
Sbjct: 1486 SRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRT 1526
Score = 116 bits (290), Expect = 2e-25
Identities = 61/167 (36%), Positives = 82/167 (49%), Gaps = 13/167 (7%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSV 817
T + C G+H CD A C G + C C G+ G+G C+D +EC+ G H+C N+
Sbjct: 1366 TDVDECEIGAHNCDMHASCLNIPG-SFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQ 1424
Query: 818 CINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSC 877
C+N PGSYRC C G F D TC + C + + C +C++ G+ + C
Sbjct: 1425 CVNTPGSYRCACSEG--FTGDGFTC----SDVDECAENINLCE---NGQCLNVPGA-YRC 1474
Query: 878 ACLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ A D C D+DECS TC N PG F C C GY
Sbjct: 1475 ECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGY 1521
Score = 100 bits (250), Expect = 7e-21
Identities = 70/235 (29%), Positives = 102/235 (43%), Gaps = 45/235 (19%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQ-GDGRNCVDENECATGFHRCGPNSVCINL 821
C +G ++C A C G Y CECA+G++ CVD NEC + C + +C++L
Sbjct: 1854 CSNGDNLCQRNADCINSPG-SYRCECAAGFKLSPNGACVDRNECLEIPNVCS-HGLCVDL 1911
Query: 822 PGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLP 881
GSY+C C +G++ + D+ C+ + + CE H C G C + GS ++C C P
Sbjct: 1912 QGSYQCICHNGFKASQDQTMCMDV----DECE--RHPC---GNGTCKNTVGS-YNCLCYP 1961
Query: 882 GYA-GDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCIPDSTSS 936
G+ + C D+DECS + C+N GSF C C GY DG CI +
Sbjct: 1962 GFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECV 2021
Query: 937 LTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEV 991
P G+ P C G C+ P G+EV
Sbjct: 2022 ALP---------------------------GSCSPGTCQNLEGSFRCICPPGYEV 2049
Score = 99.8 bits (247), Expect = 2e-20
Identities = 56/174 (32%), Positives = 80/174 (45%), Gaps = 16/174 (9%)
Query: 784 YTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
+TC+C G+ C+D NEC + CG +C N PGS+ CEC+ G+ C
Sbjct: 2554 FTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNC- 2612
Query: 844 LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAG--DGHQCTDVDECSENRC 901
+ C DG+H C Q C + G + C C GY +QC D +ECS
Sbjct: 2613 ---EDVDEC-DGNHRC----QHGCQNILGG-YRCGCPQGYIQHYQWNQCVDENECSNPNA 2663
Query: 902 HPAATCYNTPGSFSCRCQPGYYGDGFQC----IPDSTSSLTPCEQQQRHAQAQY 951
+A+CYNT GS+ C C G+ D F + + +SS PC + + Y
Sbjct: 2664 CGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGY 2717
Score = 97.4 bits (241), Expect = 8e-20
Identities = 58/163 (35%), Positives = 79/163 (48%), Gaps = 16/163 (9%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGR-NCVDENECATGFHRCGPNSVCINL 821
C +++C RC P T Y CEC GY+ D +C+D +EC + + C N C+N
Sbjct: 498 CKHHANLC-LNGRCIP-TVSSYRCECNMGYKQDANGDCIDVDECTS--NPC-TNGDCVNT 552
Query: 822 PGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLP 881
PGSY C+C +G++ + CI I + C C RCV+ GS F C C
Sbjct: 553 PGSYYCKCHAGFQRTPTKQACIDI----DECIQNGVLCK---NGRCVNTDGS-FQCICNA 604
Query: 882 GY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
G+ DG C D DEC+ C N GSF C C+PG+
Sbjct: 605 GFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGF 647
Score = 96.3 bits (238), Expect = 2e-19
Identities = 60/172 (34%), Positives = 79/172 (45%), Gaps = 21/172 (12%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN-CVDENECATGFHRC 812
D D +PC +G+ C T Y C C G++ N C+D +EC++ F +
Sbjct: 1934 DVDECERHPCGNGT--CKNTVG-------SYNCLCYPGFELTHNNDCLDIDECSSFFGQV 1984
Query: 813 GPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
N C N GS++C C GYE D CI N C +C+P C + G
Sbjct: 1985 CRNGRCFNEIGSFKCLCNEGYELTPDGKNCI----DTNECVALPGSCSP---GTCQNLEG 2037
Query: 873 STFSCACLPGYAGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGY 922
S F C C PGY C D++EC E N C +C NTPG F C C PG+
Sbjct: 2038 S-FRCICPPGYEVKSENCIDINECDEDPNIC-LFGSCTNTPGGFQCLCPPGF 2087
Score = 94.0 bits (232), Expect = 9e-19
Identities = 67/209 (32%), Positives = 89/209 (42%), Gaps = 27/209 (12%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN--CVDENECATGFHR 811
D D NPC +G C T PG+ Y C+C +G+Q C+D +EC
Sbjct: 535 DVDECTSNPCTNGD--CVNT----PGS---YYCKCHAGFQRTPTKQACIDIDECIQNGVL 585
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHG 871
C N C+N GS++C C +G+E D C+ D T C++
Sbjct: 586 C-KNGRCVNTDGSFQCICNAGFELTTDGKNCV--------DHDECTTTNMCLNGMCINED 636
Query: 872 GSTFSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGF 927
GS F C C PG+ A +G CTDVDEC C N+ GSF C C PG DG
Sbjct: 637 GS-FKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGR 695
Query: 928 QCIPDSTSSLTPCEQQQRHAQAQYAYPGA 956
C+ T + C + +PGA
Sbjct: 696 VCV--DTHMRSTCYGGIKKGVCVRPFPGA 722
Score = 91.3 bits (225), Expect = 6e-18
Identities = 91/330 (27%), Positives = 120/330 (36%), Gaps = 56/330 (16%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCIN 820
C +G H C++ + C C G + DG CVDENEC T C N C+N
Sbjct: 2298 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVN 2356
Query: 821 LPGSYRCECRSGY-------EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGS 873
+ GSYRCEC G+ E D+R C+ S + ++ C GG
Sbjct: 2357 IIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGR 2416
Query: 874 TFSCACL-----------------PGYAGDGHQCTDVDECS--ENRCHPAATCYNTPGSF 914
+ C PGY DG D+DEC N C C NT GSF
Sbjct: 2417 GWGHQCELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLC-TNGQCINTMGSF 2472
Query: 915 SCRCQPGYYGD--GFQCI--PDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQ-------- 962
C C+ GY D G CI + + S PC ++ + Y R ++ Q
Sbjct: 2473 RCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKD 2532
Query: 963 ---CDEQGNFLPLQCHGSTGFCWCVDPDG----HEVPGTQTPPGSTPPHCGPSPEPTQRP 1015
C + + C + G C P G H GS P CG P
Sbjct: 2533 LDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTP 2592
Query: 1016 PTI-CERWRENLLEHYGGTPRDDQYVPQCD 1044
+ CE R L+ G D V +CD
Sbjct: 2593 GSFSCECQRGFSLDATGLNCED---VDECD 2619
Score = 90.5 bits (223), Expect = 1e-17
Identities = 60/170 (35%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGD--GRNCVDENECATGFHRCGPNSVC 818
N C +C C G ++CEC G+ D G NC D +EC G HRC C
Sbjct: 2573 NECGSQPSLCGAKGICQNTPG-SFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHG--C 2628
Query: 819 INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
N+ G YRC C GY + C+ +NP + C G A C + GS + CA
Sbjct: 2629 QNILGGYRCGCPQGYIQHYQWNQCVDENECSNP-----NAC---GSASCYNTLGS-YKCA 2679
Query: 879 CLPGYAGD--GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDG 926
C G++ D C DV+ECS ++ C NT G + C C PGYY G
Sbjct: 2680 CPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVG 2729
Score = 88.2 bits (217), Expect = 5e-17
Identities = 52/156 (33%), Positives = 74/156 (47%), Gaps = 19/156 (12%)
Query: 776 CHPGTGVD----YTCECASGYQ--GDGRNCVDENECATGFHRCGPNSVCINLPGSYRCEC 829
C GT V+ + C+C G++ +CVD NEC+ + C N C+N+ G+Y+C C
Sbjct: 1169 CRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCR-NGKCVNMIGTYQCSC 1227
Query: 830 RSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDG 887
GY+ DR C I + C + C +C + GS + C+C GYA DG
Sbjct: 1228 NPGYQATPDRQGCTDI----DECMIMNGGC----DTQCTNSEGS-YECSCSEGYALMPDG 1278
Query: 888 HQCTDVDECSEN-RCHPAATCYNTPGSFSCRCQPGY 922
C D+DEC N C N PG + C C G+
Sbjct: 1279 RSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGF 1314
Score = 85.1 bits (209), Expect = 4e-16
Identities = 65/211 (30%), Positives = 87/211 (41%), Gaps = 46/211 (21%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGD--GRNCVDENECATGFHRCGPNSVC 818
N C MC T +C G + C C SG+ D RNC D +EC CG + +C
Sbjct: 1075 NECKAFPGMC-TYGKCRNTIG-SFKCRCNSGFALDMEERNCTDIDECRISPDLCG-SGIC 1131
Query: 819 INLPGSYRCECRSGYE--FADDRHTCILITPPANP--CEDGS---------------HTC 859
+N PGS+ CEC GYE F ++ + NP C G+ H
Sbjct: 1132 VNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1191
Query: 860 APAGQ-----------------ARCVHHGGSTFSCACLPGYAG--DGHQCTDVDECSENR 900
+P+ + +CV+ G T+ C+C PGY D CTD+DEC
Sbjct: 1192 SPSREDCVDINECSLSDNLCRNGKCVNMIG-TYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
Query: 901 CHPAATCYNTPGSFSCRCQPGY--YGDGFQC 929
C N+ GS+ C C GY DG C
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
Score = 84.7 bits (208), Expect = 5e-16
Identities = 61/180 (33%), Positives = 77/180 (42%), Gaps = 29/180 (16%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ-GDGRNCVDENECATGFHRCGPNSVC 818
GNPC +G+ C G + C C G++ G NC D NECA C C
Sbjct: 2220 GNPCGNGT--------CTNVIG-SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFR--C 2268
Query: 819 INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
+N GSY C C GY +D+ C + C +G H C G C + G TF C
Sbjct: 2269 MNTFGSYECTCPIGYALREDQKMC----KDLDECAEGLHDCESRGM-MCKNLIG-TFMCI 2322
Query: 879 CLPGYA--GDGHQCTDVDECSENRCHPA----ATCYNTPGSFSCRCQPGYY--GDGFQCI 930
C PG A DG C D +EC R P C N GS+ C C G+ G +C+
Sbjct: 2323 CPPGMARRPDGEGCVDENEC---RTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECL 2379
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/165 (36%), Positives = 72/165 (43%), Gaps = 20/165 (12%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENECATGFHRCGPNSVC 818
NP Y C C ++ C+SG DGR D NECA C N +C
Sbjct: 732 NPDYGFGEPCQP---CPAKNSAEFHGLCSSGVGITVDGR---DINECALDPDICA-NGIC 784
Query: 819 INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
NL GSYRC C SGYE CI I + C C C + GS +SC
Sbjct: 785 ENLRGSYRCNCNSGYEPDASGRNCIDI----DECLVNRLLC---DNGLCRNTPGS-YSCT 836
Query: 879 CLPGYA--GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPG 921
C PGY + C D++EC N C A C N GSF+C C PG
Sbjct: 837 CPPGYVFRTETETCEDINECESNPCVNGA-CRNNLGSFNCECSPG 880
Score = 80.9 bits (198), Expect = 8e-15
Identities = 60/189 (31%), Positives = 79/189 (41%), Gaps = 22/189 (11%)
Query: 758 TPGNPCYDGS----HMCDTTARCHPGTG-VDYTCECASGYQGDGRNCVDENECATGFHRC 812
T C DG H C+ PGT C GY DGR D +EC + C
Sbjct: 2406 TKSECCCDGGRGWGHQCELCPL--PGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLC 2460
Query: 813 GPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
N CIN GS+RC C+ GY +CI + + C C C + G
Sbjct: 2461 -TNGQCINTMGSFRCFCKVGYTTDISGTSCIDL----DECSQSPKPC----NYICKNTEG 2511
Query: 873 STFSCACLPGYA--GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCI 930
S + C+C GY DG C D+DEC + + C NT G F+C+C PG+ CI
Sbjct: 2512 S-YQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACI 2570
Query: 931 PDSTSSLTP 939
++ P
Sbjct: 2571 DNNECGSQP 2579
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/202 (31%), Positives = 78/202 (38%), Gaps = 61/202 (30%)
Query: 784 YTCECASGYQGD--GRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
Y C C SGY+ D GRNC+D +EC C N +C N PGSY C C GY F + T
Sbjct: 791 YRCNCNSGYEPDASGRNCIDIDECLVNRLLCD-NGLCRNTPGSYSCTCPPGYVFRTETET 849
Query: 842 CILITP-PANPCEDGSHT---------CAPAGQ----------------------ARC-V 868
C I +NPC +G+ C+P + +RC V
Sbjct: 850 CEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEV 909
Query: 869 HHGGSTFS---CACLPGYAGD-------------------GHQCTDVDECS--ENRCHPA 904
+ G+T CA L G G C DV+EC C P
Sbjct: 910 NINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVC-PN 968
Query: 905 ATCYNTPGSFSCRCQPGYYGDG 926
C N+ GSF C C G DG
Sbjct: 969 GRCVNSKGSFHCECPEGLTLDG 990
Score = 73.2 bits (178), Expect = 2e-12
Identities = 45/123 (36%), Positives = 56/123 (45%), Gaps = 11/123 (8%)
Query: 801 DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCA 860
D NEC C N CIN GS+RCEC GY C+ + C G+
Sbjct: 2171 DVNECLESPGICS-NGQCINTDGSFRCECPMGYNLDYTGVRCV----DTDECSIGN---- 2221
Query: 861 PAGQARCVHHGGSTFSCACLPGYA-GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQ 919
P G C + GS F C C G+ G C D++EC++N A C NT GS+ C C
Sbjct: 2222 PCGNGTCTNVIGS-FECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCP 2280
Query: 920 PGY 922
GY
Sbjct: 2281 IGY 2283
Score = 72.4 bits (176), Expect = 3e-12
Identities = 72/255 (28%), Positives = 91/255 (35%), Gaps = 78/255 (30%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVD----YTCECASGY--QGDGRNCVDENECATGFHR 811
T G C D C TT C G ++ + C C G+ +GR C D +EC T
Sbjct: 610 TDGKNCVDHDE-CTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTP--G 666
Query: 812 CGPNSVCINLPGSYRCECRSGYEFADD---------RHTC-------ILITP-------- 847
N CIN GS+RC+C G D R TC + + P
Sbjct: 667 ICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKS 726
Query: 848 -------------PANPCE-------------------DGS--HTCAP----AGQARCVH 869
P PC DG + CA C +
Sbjct: 727 ECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICEN 786
Query: 870 HGGSTFSCACLPGYAGD--GHQCTDVDECSENRCH-PAATCYNTPGSFSCRCQPGYYGDG 926
GS + C C GY D G C D+DEC NR C NTPGS+SC C PGY
Sbjct: 787 LRGS-YRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYV--- 842
Query: 927 FQCIPDSTSSLTPCE 941
F+ ++ + CE
Sbjct: 843 FRTETETCEDINECE 857
Score = 68.6 bits (166), Expect = 4e-11
Identities = 70/244 (28%), Positives = 100/244 (40%), Gaps = 36/244 (14%)
Query: 778 PGTGVDYTCECAS--GYQGDGRN--CVDENECATGFHRCGPNSVCINLPGSYRCECRSGY 833
PGT D+ C + G+ D VD +EC C N VCIN GS+RCEC +G+
Sbjct: 1782 PGTA-DFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICA-NGVCINQIGSFRCECPTGF 1839
Query: 834 EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY-AGDGHQCTD 892
+ D +L+ + C +G + C A C++ GS + C C G+ C D
Sbjct: 1840 SYND----LLLVCEDIDECSNGDNLC--QRNADCINSPGS-YRCECAAGFKLSPNGACVD 1892
Query: 893 VDECSE--NRCHPAATCYNTPGSFSCRCQPGYYG--DGFQCIPDSTSSLTPCEQQQ-RHA 947
+EC E N C C + GS+ C C G+ D C+ PC ++
Sbjct: 1893 RNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNT 1951
Query: 948 QAQY---AYPGARF-HIPQC---DEQGNFLPL-----QCHGSTGFCWCVDPDGHEVPGTQ 995
Y YPG H C DE +F +C G C+ +G+E+
Sbjct: 1952 VGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYEL---- 2007
Query: 996 TPPG 999
TP G
Sbjct: 2008 TPDG 2011
Score = 64.7 bits (156), Expect = 6e-10
Identities = 68/274 (24%), Positives = 84/274 (30%), Gaps = 116/274 (42%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C +G+H C A+C G Y C C+ G+ GDG C D +ECA + C N C+N+P
Sbjct: 1412 CSNGTHQCSINAQCVNTPG-SYRCACSEGFTGDGFTCSDVDECAENINLC-ENGQCLNVP 1469
Query: 823 GSY-----------------------------------------RCECRSGYEFADDRHT 841
G+Y C C GYE
Sbjct: 1470 GAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGN 1529
Query: 842 CILITPPANP--CEDG---------SHTCAPAGQAR-----CVHH--------------- 870
C I A+P C +G C P Q CV +
Sbjct: 1530 CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
Query: 871 ----------GGSTFSCACLPGYA----------------------GDGHQ-------CT 891
G S SC C G A G+G +
Sbjct: 1590 SLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
Query: 892 DVDECSE--NRCHPAATCYNTPGSFSCRCQPGYY 923
D+DEC E C C NT GSF C C GYY
Sbjct: 1650 DIDECQELPGLCQ-GGNCINTFGSFQCECPQGYY 1682
Score = 64.3 bits (155), Expect = 8e-10
Identities = 58/215 (26%), Positives = 77/215 (35%), Gaps = 80/215 (37%)
Query: 784 YTCECASGYQGD--GRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEF------ 835
+ C C GY+ D G NC D +ECA + N +C+N PG Y C C ++
Sbjct: 1513 FHCICDDGYELDRTGGNCTDIDECADPINCV--NGLCVNTPGRYECNCPPDFQLNPTGVG 1570
Query: 836 -ADDR-HTCILITPP-----------------------------ANPCEDGS-------H 857
D+R C L P NPCE +
Sbjct: 1571 CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYY 1630
Query: 858 TCAPAGQA--------------------------RCVHHGGSTFSCACLPGY--AGDGHQ 889
T P G+ C++ GS F C C GY + D
Sbjct: 1631 TLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGS-FQCECPQGYYLSEDTRI 1689
Query: 890 CTDVDECSENR--CHPAATCYNTPGSFSCRCQPGY 922
C D+DEC + C P TCYNT G+++C C P Y
Sbjct: 1690 CEDIDECFAHPGVCGPG-TCYNTLGNYTCICPPEY 1723
Score = 55.8 bits (133), Expect = 3e-07
Identities = 73/303 (24%), Positives = 99/303 (32%), Gaps = 71/303 (23%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCE--CASGYQGDGRNCVDENECATGFHRCGPN----- 815
C +G D +C G Y + C +G Q GR C+ N CA + GP
Sbjct: 153 CMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGR-CIGPNRCACVYGFTGPQCERDY 211
Query: 816 --SVCINLPGSYRCE-------CRSGYEFADDR----HTCILITPPANPCEDG------S 856
C + C+ C A H C + PC G +
Sbjct: 212 RTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRT 271
Query: 857 HTCAPAGQAR----------CVHHGGSTFSCACLPGY--AGDGHQCTDVDECS--ENRCH 902
C + + C++ GS F C C G+ + +C D+DECS C
Sbjct: 272 GACQDVDECQAIPGICQGGNCINTVGS-FECRCPAGHKQSETTQKCEDIDECSIIPGICE 330
Query: 903 PAATCYNTPGSFSCRCQPGYY--GDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHI 960
C NT GS+ C C GY DG +CI T R AQ
Sbjct: 331 -TGECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQ------------ 377
Query: 961 PQCDEQGNFLPLQCHGSTGFCWCVD--PDGHEVPGTQ---------TPPGSTPPHCGPSP 1009
+ G +QC G CW + P+ V G++ P G P G P
Sbjct: 378 ---ELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGGIPGSAGSRP 434
Query: 1010 EPT 1012
T
Sbjct: 435 GGT 437
Score = 54.7 bits (130), Expect = 6e-07
Identities = 58/203 (28%), Positives = 74/203 (36%), Gaps = 54/203 (26%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGY--QGDGRNCVDENE--CATGF 809
D DP N C GS C T PG + C C G+ +GR C D + C T F
Sbjct: 2061 DEDP---NICLFGS--CTNT----PG---GFQCLCPPGFVLSDNGRRCFDTRQSFCFTNF 2108
Query: 810 HRCGPNSV------------CINLPG----------------SYRCECRSGYEFADDRHT 841
G SV C +PG +++ C G+ H
Sbjct: 2109 EN-GKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHD 2167
Query: 842 CILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGD--GHQCTDVDECSEN 899
N C + C+ +C++ GS F C C GY D G +C D DECS
Sbjct: 2168 T---REDVNECLESPGICS---NGQCINTDGS-FRCECPMGYNLDYTGVRCVDTDECSIG 2220
Query: 900 RCHPAATCYNTPGSFSCRCQPGY 922
TC N GSF C C G+
Sbjct: 2221 NPCGNGTCTNVIGSFECNCNEGF 2243
Score = 52.0 bits (123), Expect = 4e-06
Identities = 44/157 (28%), Positives = 61/157 (38%), Gaps = 27/157 (17%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCV-----DENECATGFHRCGP 814
GNPC C P +Y C G +G N + D +EC C
Sbjct: 1615 GNPC----------ETCPPVNSTEYYTLCPGG-EGFRPNPITIILEDIDECQELPGLCQG 1663
Query: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
+ CIN GS++CEC GY ++D C + C C P C + G+
Sbjct: 1664 GN-CINTFGSFQCECPQGYYLSEDTRIC----EDIDECFAHPGVCGP---GTCYNTLGN- 1714
Query: 875 FSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYN 909
++C C P Y GH C D+ + R + TC N
Sbjct: 1715 YTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCEN 1751
Score = 48.5 bits (114), Expect = 4e-05
Identities = 43/157 (27%), Positives = 52/157 (33%), Gaps = 32/157 (20%)
Query: 796 GRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI------------ 843
G C D NEC F PN C+N GS+ CEC G C+
Sbjct: 950 GVTCEDVNECEV-FPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWD 1008
Query: 844 ---LITPPANPCEDGSHTCAPAGQ-----ARCVHHGGSTFSCACL--PGYAGDGHQCT-- 891
I P + CA C G + C G+A G T
Sbjct: 1009 EDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGR 1068
Query: 892 ----DVDECS--ENRCHPAATCYNTPGSFSCRCQPGY 922
D++EC C C NT GSF CRC G+
Sbjct: 1069 PFYKDINECKAFPGMC-TYGKCRNTIGSFKCRCNSGF 1104
Score = 47.8 bits (112), Expect = 7e-05
Identities = 53/173 (30%), Positives = 60/173 (34%), Gaps = 38/173 (21%)
Query: 773 TARC-HPGTGVDYTCECASGYQGDG-RNCVDENECATGFHRCGPNSVCINLPGSYRCECR 830
+ RC + GT D C+C GY G V EN C G GPN RC C
Sbjct: 150 SVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPN----------RCACV 199
Query: 831 SGY---EFADDRHTCILITPPANPCEDGSHT---------CAPAGQARCVHHGGSTFSCA 878
G+ + D T T N G T CA G+A G C
Sbjct: 200 YGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRA----WGHPCEMCP 255
Query: 879 CLPGYAGDGH-------QCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPGY 922
P G C DVDEC C C NT GSF CRC G+
Sbjct: 256 AQPQPCRRGFIPNIRTGACQDVDECQAIPGICQ-GGNCINTVGSFECRCPAGH 307
Score = 36.2 bits (82), Expect = 0.22
Identities = 15/54 (27%), Positives = 24/54 (44%)
Query: 471 IGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCL 524
+G + + T + + CE C HA C + F C C+ + GNG C+
Sbjct: 1354 LGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCI 1407
>gi|194328809 latent transforming growth factor beta binding protein 3
isoform 1 [Homo sapiens]
Length = 1303
Score = 116 bits (291), Expect = 1e-25
Identities = 99/322 (30%), Positives = 123/322 (38%), Gaps = 57/322 (17%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ----GDGRNCVDENECATGF 809
D + PC G +C TG Y C C GY+ GR+CVD NECA
Sbjct: 616 DVNECEAEPCGPGRGIC-------MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP- 667
Query: 810 HRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG--QARC 867
H CG CIN PG Y+C C GY R PP CED P+ +C
Sbjct: 668 HLCGDGGFCINFPGHYKCNCYPGYRLKASR-------PPV--CEDIDECRDPSSCPDGKC 718
Query: 868 VHHGGSTFSCACLPGYAGDGH-QCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYG-- 924
+ GS AC PGY G C DV+EC+E C N PGSF C C GY
Sbjct: 719 ENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778
Query: 925 DGFQCIP-DSTSSLTPCEQQ---------QRHAQAQYAYPGARFH---IPQCDEQGNFLP 971
DG C+ D + C+ Q + Y R H I +CD +
Sbjct: 779 DGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG 838
Query: 972 LQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYG 1031
C + G C+ P GH + G + C E +Q P++C L H
Sbjct: 839 GDCINTNGSYRCLCPQGHRLVGGR--------KCQDIDECSQ-DPSLC-------LPHGA 882
Query: 1032 GTPRDDQYVPQCDDLGHFIPLQ 1053
YV CD+ F P Q
Sbjct: 883 CKNLQGSYVCVCDE--GFTPTQ 902
Score = 99.4 bits (246), Expect = 2e-20
Identities = 64/178 (35%), Positives = 79/178 (44%), Gaps = 21/178 (11%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECATGFHRCGP- 814
T + C ++C C PG DY+C C GY+ R CVD NEC CGP
Sbjct: 573 TETDECRLNQNICGH-GECVPGPP-DYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPG 628
Query: 815 NSVCINLPGSYRCECRSGYEF--ADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
+C+N GSY C C GY +C+ + A P H C G C++ G
Sbjct: 629 RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP-----HLCGDGG--FCINFPG 681
Query: 873 STFSCACLPGY---AGDGHQCTDVDECSENRCHPAATCYNTPGSFSC-RCQPGYYGDG 926
+ C C PGY A C D+DEC + P C N PGSF C CQPGY G
Sbjct: 682 H-YKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG 738
Score = 96.7 bits (239), Expect = 1e-19
Identities = 61/181 (33%), Positives = 88/181 (48%), Gaps = 29/181 (16%)
Query: 749 GPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECA 806
G ++ ++ G+PC G C+ PG+ + C CA GY DGR+C+D +EC
Sbjct: 740 GACRDVNECAEGSPCSPG--WCENL----PGS---FRCTCAQGYAPAPDGRSCLDVDECE 790
Query: 807 TGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG--Q 864
G N +C N PGS++C+C SGY + DR + CED PA
Sbjct: 791 AG--DVCDNGICSNTPGSFQCQCLSGYHLSRDR----------SHCEDIDECDFPAACIG 838
Query: 865 ARCVHHGGSTFSCACLPGY-AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPG 921
C++ GS + C C G+ G +C D+DECS+ + C P C N GS+ C C G
Sbjct: 839 GDCINTNGS-YRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
Query: 922 Y 922
+
Sbjct: 898 F 898
Score = 75.1 bits (183), Expect = 4e-13
Identities = 56/210 (26%), Positives = 81/210 (38%), Gaps = 30/210 (14%)
Query: 801 DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCA 860
+ +EC + CG + C+ P Y C C GY C+ N CE + C
Sbjct: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCV----DVNECE--AEPCG 626
Query: 861 PAGQARCVHHGGSTFSCACLPGY----AGDGHQCTDVDECSE-NRCHPAATCYNTPGSFS 915
P G+ C++ GGS ++C C GY G C D++EC++ + C C N PG +
Sbjct: 627 P-GRGICMNTGGS-YNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYK 684
Query: 916 CRCQPGY---------YGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFH------- 959
C C PGY D +C S+ CE + + PG R
Sbjct: 685 CNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRD 744
Query: 960 IPQCDEQGNFLPLQCHGSTGFCWCVDPDGH 989
+ +C E P C G C G+
Sbjct: 745 VNECAEGSPCSPGWCENLPGSFRCTCAQGY 774
Score = 72.4 bits (176), Expect = 3e-12
Identities = 80/324 (24%), Positives = 109/324 (33%), Gaps = 76/324 (23%)
Query: 758 TPGN---PCYDGSHM------------CDTTARCHPG----TGVDYTCECASGYQ-GDGR 797
TPG+ C G H+ CD A C G T Y C C G++ GR
Sbjct: 803 TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGR 862
Query: 798 NCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP------ 851
C D +EC+ C P+ C NL GSY C C G+ D+H C + P +
Sbjct: 863 KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLN 922
Query: 852 ------CEDGSHTCAPAGQARCVHHGGSTFSCACLP-----------------GYAGDGH 888
C+ T + C G C P GY D +
Sbjct: 923 FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNN 982
Query: 889 QCT-------DVDECS--ENRCHPAATCYNTPGSFSCRCQPGYYGDG--FQCIPDSTSSL 937
D+DEC + C NT + C C+ G+Y DG +C+ D L
Sbjct: 983 IVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECV-DVDECL 1041
Query: 938 TPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTP 997
E R+ + G R C + P Q C+ P+ +V Q P
Sbjct: 1042 D--ESNCRNGVCENTRGGYRC---ACTPPAEYSPAQRQ-------CLSPEEMDVDECQDP 1089
Query: 998 PGSTPPHCGPSPEPTQ---RPPTI 1018
P C P + RPP +
Sbjct: 1090 AACRPGRCVNLPGSYRCECRPPWV 1113
Score = 55.5 bits (132), Expect = 4e-07
Identities = 52/179 (29%), Positives = 68/179 (37%), Gaps = 52/179 (29%)
Query: 766 GSHMCDTTARCHPGTGVDYTCECASGYQGDGR--NCVDENECATGFHRCGPNSVCINLPG 823
GS +C +C T Y C C G+ DG CVD +EC + C N VC N G
Sbjct: 1001 GSEICKE-GKC-VNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CR-NGVCENTRG 1056
Query: 824 SYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY 883
YRC C TPPA +PA Q +C+
Sbjct: 1057 GYRCAC----------------TPPAE--------YSPA-QRQCL--------------- 1076
Query: 884 AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGFQC-IPDSTSSLTP 939
+ DVDEC + C N PGS+ C C+P + G C +P+S + P
Sbjct: 1077 ---SPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAP 1132
Score = 48.5 bits (114), Expect = 4e-05
Identities = 47/171 (27%), Positives = 61/171 (35%), Gaps = 46/171 (26%)
Query: 755 SDPTPG----NPCYDGSHMCDTTARCHPGTGVDYT-------------CECASGYQG-DG 796
S+P PG C ++CH + YT +C GY+ +
Sbjct: 291 SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350
Query: 797 RNCVDENECAT-GFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITP-------- 847
+C D NECA G R G C+N PGSYRC C G+ R CI P
Sbjct: 351 THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
Query: 848 ---PANPCEDGSHT-------CAPAGQA------RCVHHGGSTFSCACLPG 882
P + C+ T C G+A RC G + F C G
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
Score = 46.2 bits (108), Expect = 2e-04
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 13/99 (13%)
Query: 750 PVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN--CVDENECAT 807
P EDS + C C + RC P G CEC G+Q D CVD +EC
Sbjct: 1208 PRDEDSSEEDSDEC-----RC-VSGRCVPRPG-GAVCECPGGFQLDASRARCVDIDECRE 1260
Query: 808 GFHR---CGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
R C + C+N GS+RC C++G+ + C+
Sbjct: 1261 LNQRGLLC-KSERCVNTSGSFRCVCKAGFARSRPHGACV 1298
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/238 (26%), Positives = 74/238 (31%), Gaps = 77/238 (32%)
Query: 759 PGNPCY-------DGSHM-------CDTTARCHPG----TGVDYTCECA--SGYQGDGRN 798
PG CY DG+ + C + C G T Y C C + Y R
Sbjct: 1015 PGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQ 1074
Query: 799 CV-----DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPC- 852
C+ D +EC C P C+NLPGSYRCECR + C L PA
Sbjct: 1075 CLSPEEMDVDECQDPA-ACRPGR-CVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAP 1132
Query: 853 -----------EDGSHTCAPAGQA----RCVHHGGSTFSCACLP-GYAGDGHQC------ 890
EDG AG A C G + C P G G C
Sbjct: 1133 ERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE 1192
Query: 891 -----------------------TDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGD 925
D DEC RC + C PG C C G+ D
Sbjct: 1193 SNSFWDTSPLLLGKPPRDEDSSEEDSDEC---RC-VSGRCVPRPGGAVCECPGGFQLD 1246
Score = 41.2 bits (95), Expect = 0.007
Identities = 30/93 (32%), Positives = 39/93 (41%), Gaps = 10/93 (10%)
Query: 838 DRHTCILITPPANP--CEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQ--CTDV 893
D +L PP + E+ S C RCV G C C G+ D + C D+
Sbjct: 1198 DTSPLLLGKPPRDEDSSEEDSDECRCVS-GRCVPRPGGAV-CECPGGFQLDASRARCVDI 1255
Query: 894 DECSENRCH----PAATCYNTPGSFSCRCQPGY 922
DEC E + C NT GSF C C+ G+
Sbjct: 1256 DECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288
Score = 38.5 bits (88), Expect = 0.045
Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 3/65 (4%)
Query: 879 CLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCIPDSTS 935
C GY + C D++EC+ C N PGS+ C C PG+ QCI D
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
Query: 936 SLTPC 940
+ C
Sbjct: 401 EKSLC 405
Score = 32.3 bits (72), Expect = 3.2
Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 889 QCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGY--YGDGFQCIPDSTSSLTPC 940
Q T+ DEC ++N C C P +SC C PGY + C+ + PC
Sbjct: 571 QVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPC 625
Score = 31.2 bits (69), Expect = 7.2
Identities = 33/146 (22%), Positives = 48/146 (32%), Gaps = 24/146 (16%)
Query: 381 GQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHP 440
G +P E+ S APP D + P E Q +P PA P
Sbjct: 486 GPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA-------TTTPARP 538
Query: 441 EEEIVLRSYPASGH----TTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCS 496
E++ R P + P SR E+ + T+V + C N C
Sbjct: 539 YPELISRPSPPTMRWFLPDLPPSRSAVEI-------APTQV-----TETDECRLNQNICG 586
Query: 497 RHAFCTDYATGFCCHCQSKFYGNGKH 522
H C + CHC + + +H
Sbjct: 587 -HGECVPGPPDYSCHCNPGYRSHPQH 611
>gi|18497288 latent transforming growth factor beta binding protein 3
isoform 2 [Homo sapiens]
Length = 1256
Score = 116 bits (291), Expect = 1e-25
Identities = 99/322 (30%), Positives = 123/322 (38%), Gaps = 57/322 (17%)
Query: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ----GDGRNCVDENECATGF 809
D + PC G +C TG Y C C GY+ GR+CVD NECA
Sbjct: 616 DVNECEAEPCGPGRGIC-------MNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP- 667
Query: 810 HRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG--QARC 867
H CG CIN PG Y+C C GY R PP CED P+ +C
Sbjct: 668 HLCGDGGFCINFPGHYKCNCYPGYRLKASR-------PPV--CEDIDECRDPSSCPDGKC 718
Query: 868 VHHGGSTFSCACLPGYAGDGH-QCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYG-- 924
+ GS AC PGY G C DV+EC+E C N PGSF C C GY
Sbjct: 719 ENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAP 778
Query: 925 DGFQCIP-DSTSSLTPCEQQ---------QRHAQAQYAYPGARFH---IPQCDEQGNFLP 971
DG C+ D + C+ Q + Y R H I +CD +
Sbjct: 779 DGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIG 838
Query: 972 LQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYG 1031
C + G C+ P GH + G + C E +Q P++C L H
Sbjct: 839 GDCINTNGSYRCLCPQGHRLVGGR--------KCQDIDECSQ-DPSLC-------LPHGA 882
Query: 1032 GTPRDDQYVPQCDDLGHFIPLQ 1053
YV CD+ F P Q
Sbjct: 883 CKNLQGSYVCVCDE--GFTPTQ 902
Score = 99.4 bits (246), Expect = 2e-20
Identities = 64/178 (35%), Positives = 79/178 (44%), Gaps = 21/178 (11%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECATGFHRCGP- 814
T + C ++C C PG DY+C C GY+ R CVD NEC CGP
Sbjct: 573 TETDECRLNQNICGH-GECVPGPP-DYSCHCNPGYRSHPQHRYCVDVNECEA--EPCGPG 628
Query: 815 NSVCINLPGSYRCECRSGYEF--ADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
+C+N GSY C C GY +C+ + A P H C G C++ G
Sbjct: 629 RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKP-----HLCGDGG--FCINFPG 681
Query: 873 STFSCACLPGY---AGDGHQCTDVDECSENRCHPAATCYNTPGSFSC-RCQPGYYGDG 926
+ C C PGY A C D+DEC + P C N PGSF C CQPGY G
Sbjct: 682 H-YKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQG 738
Score = 96.7 bits (239), Expect = 1e-19
Identities = 61/181 (33%), Positives = 88/181 (48%), Gaps = 29/181 (16%)
Query: 749 GPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECA 806
G ++ ++ G+PC G C+ PG+ + C CA GY DGR+C+D +EC
Sbjct: 740 GACRDVNECAEGSPCSPG--WCENL----PGS---FRCTCAQGYAPAPDGRSCLDVDECE 790
Query: 807 TGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAG--Q 864
G N +C N PGS++C+C SGY + DR + CED PA
Sbjct: 791 AG--DVCDNGICSNTPGSFQCQCLSGYHLSRDR----------SHCEDIDECDFPAACIG 838
Query: 865 ARCVHHGGSTFSCACLPGY-AGDGHQCTDVDECSE--NRCHPAATCYNTPGSFSCRCQPG 921
C++ GS + C C G+ G +C D+DECS+ + C P C N GS+ C C G
Sbjct: 839 GDCINTNGS-YRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEG 897
Query: 922 Y 922
+
Sbjct: 898 F 898
Score = 75.1 bits (183), Expect = 4e-13
Identities = 56/210 (26%), Positives = 81/210 (38%), Gaps = 30/210 (14%)
Query: 801 DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCA 860
+ +EC + CG + C+ P Y C C GY C+ N CE + C
Sbjct: 574 ETDECRLNQNICG-HGECVPGPPDYSCHCNPGYRSHPQHRYCV----DVNECE--AEPCG 626
Query: 861 PAGQARCVHHGGSTFSCACLPGY----AGDGHQCTDVDECSE-NRCHPAATCYNTPGSFS 915
P G+ C++ GGS ++C C GY G C D++EC++ + C C N PG +
Sbjct: 627 P-GRGICMNTGGS-YNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYK 684
Query: 916 CRCQPGY---------YGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFH------- 959
C C PGY D +C S+ CE + + PG R
Sbjct: 685 CNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRD 744
Query: 960 IPQCDEQGNFLPLQCHGSTGFCWCVDPDGH 989
+ +C E P C G C G+
Sbjct: 745 VNECAEGSPCSPGWCENLPGSFRCTCAQGY 774
Score = 67.8 bits (164), Expect = 7e-11
Identities = 60/233 (25%), Positives = 81/233 (34%), Gaps = 60/233 (25%)
Query: 758 TPGN---PCYDGSHM------------CDTTARCHPG----TGVDYTCECASGYQ-GDGR 797
TPG+ C G H+ CD A C G T Y C C G++ GR
Sbjct: 803 TPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGR 862
Query: 798 NCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANP------ 851
C D +EC+ C P+ C NL GSY C C G+ D+H C + P +
Sbjct: 863 KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLN 922
Query: 852 ------CEDGSHTCAPAGQARCVHHGGSTFSCACLP-----------------GYAGDGH 888
C+ T + C G C P GY D +
Sbjct: 923 FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNN 982
Query: 889 QCT-------DVDECS--ENRCHPAATCYNTPGSFSCRCQPGYYGDG--FQCI 930
D+DEC + C NT + C C+ G+Y DG +C+
Sbjct: 983 IVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECV 1035
Score = 48.5 bits (114), Expect = 4e-05
Identities = 47/171 (27%), Positives = 61/171 (35%), Gaps = 46/171 (26%)
Query: 755 SDPTPG----NPCYDGSHMCDTTARCHPGTGVDYT-------------CECASGYQG-DG 796
S+P PG C ++CH + YT +C GY+ +
Sbjct: 291 SNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNS 350
Query: 797 RNCVDENECAT-GFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITP-------- 847
+C D NECA G R G C+N PGSYRC C G+ R CI P
Sbjct: 351 THCQDINECAMPGVCRHGD---CLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFR 407
Query: 848 ---PANPCEDGSHT-------CAPAGQA------RCVHHGGSTFSCACLPG 882
P + C+ T C G+A RC G + F C G
Sbjct: 408 LVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAG 458
Score = 46.2 bits (108), Expect = 2e-04
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 13/99 (13%)
Query: 750 PVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN--CVDENECAT 807
P EDS + C C + RC P G CEC G+Q D CVD +EC
Sbjct: 1161 PRDEDSSEEDSDEC-----RC-VSGRCVPRPG-GAVCECPGGFQLDASRARCVDIDECRE 1213
Query: 808 GFHR---CGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
R C + C+N GS+RC C++G+ + C+
Sbjct: 1214 LNQRGLLC-KSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
Score = 44.3 bits (103), Expect = 8e-04
Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 6/80 (7%)
Query: 766 GSHMCDTTARCHPGTGVDYTCECASGYQGDGR--NCVDENECATGFHRCGPNSVCINLPG 823
GS +C +C T Y C C G+ DG CVD +EC + C N VC N G
Sbjct: 1001 GSEICKE-GKC-VNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN-CR-NGVCENTRG 1056
Query: 824 SYRCECRSGYEFADDRHTCI 843
YRC C E++ + C+
Sbjct: 1057 GYRCACTPPAEYSPAQRQCL 1076
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 6/68 (8%)
Query: 855 GSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGH--QCTDVDECSENRCHPAATCYNTPG 912
GS C + +CV+ + C C G+ DG+ +C DVDEC + C NT G
Sbjct: 1001 GSEICK---EGKCVNTQPG-YECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRG 1056
Query: 913 SFSCRCQP 920
+ C C P
Sbjct: 1057 GYRCACTP 1064
Score = 41.2 bits (95), Expect = 0.007
Identities = 30/93 (32%), Positives = 39/93 (41%), Gaps = 10/93 (10%)
Query: 838 DRHTCILITPPANP--CEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQ--CTDV 893
D +L PP + E+ S C RCV G C C G+ D + C D+
Sbjct: 1151 DTSPLLLGKPPRDEDSSEEDSDECRCVS-GRCVPRPGGAV-CECPGGFQLDASRARCVDI 1208
Query: 894 DECSENRCH----PAATCYNTPGSFSCRCQPGY 922
DEC E + C NT GSF C C+ G+
Sbjct: 1209 DECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1241
Score = 38.5 bits (88), Expect = 0.045
Identities = 21/65 (32%), Positives = 28/65 (43%), Gaps = 3/65 (4%)
Query: 879 CLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGFQCIPDSTS 935
C GY + C D++EC+ C N PGS+ C C PG+ QCI D
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPE 400
Query: 936 SLTPC 940
+ C
Sbjct: 401 EKSLC 405
Score = 32.3 bits (72), Expect = 3.2
Identities = 18/56 (32%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 889 QCTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGY--YGDGFQCIPDSTSSLTPC 940
Q T+ DEC ++N C C P +SC C PGY + C+ + PC
Sbjct: 571 QVTETDECRLNQNICGHGE-CVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPC 625
Score = 31.2 bits (69), Expect = 7.2
Identities = 33/146 (22%), Positives = 48/146 (32%), Gaps = 24/146 (16%)
Query: 381 GQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHP 440
G +P E+ S APP D + P E Q +P PA P
Sbjct: 486 GPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA-------TTTPARP 538
Query: 441 EEEIVLRSYPASGH----TTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCS 496
E++ R P + P SR E+ + T+V + C N C
Sbjct: 539 YPELISRPSPPTMRWFLPDLPPSRSAVEI-------APTQV-----TETDECRLNQNICG 586
Query: 497 RHAFCTDYATGFCCHCQSKFYGNGKH 522
H C + CHC + + +H
Sbjct: 587 -HGECVPGPPDYSCHCNPGYRSHPQH 611
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 114 bits (285), Expect = 6e-25
Identities = 60/164 (36%), Positives = 81/164 (49%), Gaps = 13/164 (7%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCIN 820
N C G+H C A C T + C C+ G+ GDG C D +EC+ G H C ++ C N
Sbjct: 1324 NECEIGAHNCGKHAVC-TNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKN 1382
Query: 821 LPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACL 880
GSYRC C+ GY D TC + C + + C G +C++ G + C C
Sbjct: 1383 TMGSYRCLCKEGY--TGDGFTC----TDLDECSENLNLC---GNGQCLNAPGG-YRCECD 1432
Query: 881 PGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
G+ + DG C D+DECS TC+N PG F C C+ GY
Sbjct: 1433 MGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGY 1476
Score = 111 bits (277), Expect = 5e-24
Identities = 62/162 (38%), Positives = 77/162 (47%), Gaps = 13/162 (8%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
C +G+HMC A C G Y C C GY GDG C D +EC+ + CG N C+N P
Sbjct: 1367 CSNGTHMCSQHADCKNTMG-SYRCLCKEGYTGDGFTCTDLDECSENLNLCG-NGQCLNAP 1424
Query: 823 GSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPG 882
G YRCEC G+ + D C I + P TC H+ F C C G
Sbjct: 1425 GGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTC---------HNLPGLFRCECEIG 1475
Query: 883 YAGD--GHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
Y D G CTDV+EC + + C NTPGS+ C C P +
Sbjct: 1476 YELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDF 1517
Score = 108 bits (270), Expect = 4e-23
Identities = 63/174 (36%), Positives = 81/174 (46%), Gaps = 16/174 (9%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDG--RNCVDENECATGFHRCGPNSVC 818
N C ++C + C G + C C GY G C D NEC G H CG ++VC
Sbjct: 1282 NECDLNPNIC-LSGTCENTKG-SFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVC 1339
Query: 819 INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
N GS++C C G+ D C + C +G+H C+ A C + GS + C
Sbjct: 1340 TNTAGSFKCSCSPGW--IGDGIKC----TDLDECSNGTHMCSQ--HADCKNTMGS-YRCL 1390
Query: 879 CLPGYAGDGHQCTDVDECSEN-RCHPAATCYNTPGSFSCRCQPGYY--GDGFQC 929
C GY GDG CTD+DECSEN C N PG + C C G+ DG C
Sbjct: 1391 CKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKAC 1444
Score = 101 bits (251), Expect = 6e-21
Identities = 54/141 (38%), Positives = 70/141 (49%), Gaps = 10/141 (7%)
Query: 784 YTCECASGY-QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTC 842
+ C C G+ +C+D +ECA+G N CIN GS++C+C GYE A D TC
Sbjct: 1912 FNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTC 1971
Query: 843 ILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDEC-SENRC 901
+ I N C CAP C + GS + C C PGY+ +C D+DEC E
Sbjct: 1972 VDI----NECLLEPRKCAP---GTCQNLDGS-YRCICPPGYSLQNEKCEDIDECVEEPEI 2023
Query: 902 HPAATCYNTPGSFSCRCQPGY 922
TC NT GSF C C G+
Sbjct: 2024 CALGTCSNTEGSFKCLCPEGF 2044
Score = 100 bits (250), Expect = 7e-21
Identities = 82/251 (32%), Positives = 110/251 (43%), Gaps = 38/251 (15%)
Query: 713 PRHPSFPTTQQLNVDRVFALYNDEERVLRFAV----TNQIGPVK-----------EDSDP 757
PR P F T + N F N+ + + N IG K E+ +
Sbjct: 1009 PRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNC 1068
Query: 758 TPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDG---RNCVDENECATGFHRCGP 814
T + C +C +C G D+ C+C GY+ +NC+D +EC C
Sbjct: 1069 TDIDECRISPDLCGR-GQCVNTPG-DFECKCDEGYESGFMMMKNCMDIDECQRDPLLCR- 1125
Query: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
VC N GSYRCEC G++ + + CI I N CE +H C P G RCV+ G
Sbjct: 1126 GGVCHNTEGSYRCECPPGHQLSPNISACIDI----NECELSAHLC-PNG--RCVNLIGK- 1177
Query: 875 FSCACLPGY--AGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPD 932
+ CAC PGY D C D+DECS C N+ GS+ C CQP GF +PD
Sbjct: 1178 YQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQP-----GFALMPD 1232
Query: 933 --STSSLTPCE 941
S + + CE
Sbjct: 1233 QRSCTDIDECE 1243
Score = 100 bits (249), Expect = 1e-20
Identities = 58/187 (31%), Positives = 86/187 (45%), Gaps = 18/187 (9%)
Query: 784 YTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCI 843
+TC+C G+ +C+D NEC + + CG +C N PGS+ CEC+ G+ +C
Sbjct: 2507 FTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSC- 2565
Query: 844 LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAG--DGHQCTDVDECSENRC 901
+ CE G+H C Q C + G + C+C GY +QC D +EC
Sbjct: 2566 ---EDVDECE-GNHRC----QHGCQNIIGG-YRCSCPQGYLQHYQWNQCVDENECLSAHI 2616
Query: 902 HPAATCYNTPGSFSCRCQPGY----YGDGFQCIPDSTSSLTPCEQQQRHAQAQY--AYPG 955
A+C+NT GS+ C C G+ + G Q I + S+ PC + + Y P
Sbjct: 2617 CGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPP 2676
Query: 956 ARFHIPQ 962
F I Q
Sbjct: 2677 GYFRIGQ 2683
Score = 98.6 bits (244), Expect = 4e-20
Identities = 60/171 (35%), Positives = 78/171 (45%), Gaps = 18/171 (10%)
Query: 776 CHPGTGVDYTCECASGYQGDGR--NCVDENECATGFHRCGPNSVCINLPGSYRCECRSGY 833
CH G Y CEC G+Q C+D NEC H C PN C+NL G Y+C C GY
Sbjct: 1129 CHNTEG-SYRCECPPGHQLSPNISACIDINECELSAHLC-PNGRCVNLIGKYQCACNPGY 1186
Query: 834 EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCT 891
DR C+ I + C + C + C + GS + C+C PG+A D CT
Sbjct: 1187 HSTPDRLFCVDI----DECSIMNGGC----ETFCTNSEGS-YECSCQPGFALMPDQRSCT 1237
Query: 892 DVDECSEN-RCHPAATCYNTPGSFSCRCQPGYYG--DGFQCIPDSTSSLTP 939
D+DEC +N C N PG + C C G+ D C+ + L P
Sbjct: 1238 DIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNP 1288
Score = 95.5 bits (236), Expect = 3e-19
Identities = 78/226 (34%), Positives = 97/226 (42%), Gaps = 37/226 (16%)
Query: 713 PRHPSFPTTQQLNVDR--VFALYNDEE--RVLRFAVTNQIGPVKEDSDPTPGNPCYDGSH 768
P P FP Q+ V R V LY E RVL VT+ V+ +
Sbjct: 414 PVPPGFPPGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVR---------------Y 458
Query: 769 MCDTTARCHPGTGVDYTCECASGYQGDGRN-CVDENECATGFHRCGPNSVCINLPGSYRC 827
+C RC P G CEC G+Q D R C+D +EC + C CIN GSY C
Sbjct: 459 LCQN-GRCIPTPG-SCRCECNKGFQLDLRGECIDVDECEK--NPCAGGE-CINNQGSYTC 513
Query: 828 ECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGY--AG 885
+CR+GY+ R C I + C C RC++ GS F C C G+
Sbjct: 514 QCRAGYQSTLTRTECRDI----DECLQNGRIC---NNGRCINTDGS-FHCVCNAGFHVTR 565
Query: 886 DGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYY--GDGFQC 929
DG C D+DECS C N GSF C C+PG+ DG C
Sbjct: 566 DGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYC 611
Score = 91.3 bits (225), Expect = 6e-18
Identities = 63/186 (33%), Positives = 80/186 (43%), Gaps = 22/186 (11%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVD----YTCECASGYQ-GDGRNCVDENECATGFHRCGP 814
GN C D C C GT + + C C G++ G C D NECA C
Sbjct: 2161 GNECVDTDE-CSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAF 2219
Query: 815 NSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGST 874
C+N GSY C+C GY +DR C + CE+G H C Q C + G T
Sbjct: 2220 R--CVNTYGSYECKCPVGYVLREDRRMC----KDEDECEEGKHDCTEK-QMECKNLIG-T 2271
Query: 875 FSCACLPGY--AGDGHQCTDVDEC-SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIP 931
+ C C PGY DG C D +EC ++ C NT GS++C C DGF P
Sbjct: 2272 YMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCEC-----NDGFTASP 2326
Query: 932 DSTSSL 937
+ L
Sbjct: 2327 NQDECL 2332
Score = 85.1 bits (209), Expect = 4e-16
Identities = 50/143 (34%), Positives = 71/143 (49%), Gaps = 15/143 (10%)
Query: 784 YTCECASGYQGDGRN--CVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
+ CEC G+ + + C D +EC G C N+ CIN GSYRC+C+ GY F
Sbjct: 1789 FRCECPVGFFYNDKLLVCEDIDECQNG-PVCQRNAECINTAGSYRCDCKPGYRFTSTGQ- 1846
Query: 842 CILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQ--CTDVDECSEN 899
N C++ + C+ +C+ GS F C C G+ + Q C D++EC +
Sbjct: 1847 ----CNDRNECQEIPNICS---HGQCIDTVGS-FYCLCHTGFKTNDDQTMCLDINECERD 1898
Query: 900 RCHPAATCYNTPGSFSCRCQPGY 922
C TC NT GSF+CRC G+
Sbjct: 1899 AC-GNGTCRNTIGSFNCRCNHGF 1920
Score = 84.7 bits (208), Expect = 5e-16
Identities = 79/274 (28%), Positives = 104/274 (37%), Gaps = 37/274 (13%)
Query: 763 CYDGSHMC-DTTARCHPGTGVDYTCECASGYQG--DGRNCVDENECATGFHRCGPNSVCI 819
C +G H C + C G Y C C GYQ DG CVDENEC T C N C+
Sbjct: 2251 CEEGKHDCTEKQMECKNLIGT-YMCICGPGYQRRPDGEGCVDENECQTKPGIC-ENGRCL 2308
Query: 820 NLPGSYRCECRSGY-------EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGG 872
N GSY CEC G+ E D+R N C+ GS P ++ C GG
Sbjct: 2309 NTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGG 2368
Query: 873 STFSCAC--------------LPGYAGDGHQCTDVDECS--ENRCHPAATCYNTPGSFSC 916
+ C P G D+DEC + C C N GS+ C
Sbjct: 2369 RGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCR-NGECVNDRGSYHC 2427
Query: 917 RCQPGYYGD--GFQCIP--DSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPL 972
C+ GY D G C+ + + PC ++ + Y + +I Q D +
Sbjct: 2428 ICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLD 2487
Query: 973 QCHGSTGFC--WCVDPDGHEVPGTQTPPGSTPPH 1004
+C C CV+ G + PPG T H
Sbjct: 2488 ECATKQHNCQFLCVNTIGGFT--CKCPPGFTQHH 2519
Score = 80.1 bits (196), Expect = 1e-14
Identities = 54/145 (37%), Positives = 65/145 (44%), Gaps = 13/145 (8%)
Query: 776 CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEF 835
C +Y C+SG G D NECA C PN +C NL G+Y+C C SGYE
Sbjct: 699 CPAQNSAEYQALCSSG-PGMTSAGSDINECALDPDIC-PNGICENLRGTYKCICNSGYEV 756
Query: 836 ADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPG--YAGDGHQCTDV 893
C+ I N C S C +C + GS F C C G Y D C D+
Sbjct: 757 DSTGKNCVDI----NECVLNSLLC---DNGQCRNTPGS-FVCTCPKGFIYKPDLKTCEDI 808
Query: 894 DECSENRCHPAATCYNTPGSFSCRC 918
DEC + C C N+PGSF C C
Sbjct: 809 DECESSPC-INGVCKNSPGSFICEC 832
Score = 75.9 bits (185), Expect = 3e-13
Identities = 57/188 (30%), Positives = 79/188 (42%), Gaps = 16/188 (8%)
Query: 758 TPGNPCYDGSHMCDTTARCHPGTG-VDYTCECASGYQGDGRNCVDENECATGFHRCGPNS 816
T C DG P G V + C G +G N D +EC H N
Sbjct: 2359 TKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHG-RGFMTNGADIDECKV-IHDVCRNG 2416
Query: 817 VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFS 876
C+N GSY C C++GY +C+ + N C C C + GS +
Sbjct: 2417 ECVNDRGSYHCICKTGYTPDITGTSCVDL----NECNQAPKPC----NFICKNTEGS-YQ 2467
Query: 877 CACLPGYA--GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDS- 933
C+C GY DG C D+DEC+ + + C NT G F+C+C PG+ CI ++
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNE 2527
Query: 934 -TSSLTPC 940
TS + C
Sbjct: 2528 CTSDINLC 2535
Score = 72.8 bits (177), Expect = 2e-12
Identities = 54/165 (32%), Positives = 71/165 (43%), Gaps = 23/165 (13%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVDYTCECASGY-QGDGRNCVDENECATGFHRCGPNSVC 818
G+PC +C T P C SG G + VD +EC + C
Sbjct: 2093 GDPC----ELCPT----EPDEAFRQICPYGSGIIVGPDDSAVDMDECKEP--DVCKHGQC 2142
Query: 819 INLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCA 878
IN GSYRCEC GY A + C+ + C G+ P G C + G F C
Sbjct: 2143 INTDGSYRCECPFGYILAGNE--CV----DTDECSVGN----PCGNGTCKNVIGG-FECT 2191
Query: 879 CLPGYA-GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGY 922
C G+ G C D++EC++N A C NT GS+ C+C GY
Sbjct: 2192 CEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGY 2236
Score = 71.6 bits (174), Expect = 5e-12
Identities = 58/184 (31%), Positives = 70/184 (38%), Gaps = 42/184 (22%)
Query: 776 CHPGTGVDYTCECASGYQGD--GRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGY 833
CH G+ + CEC GY+ D G NC D NEC N C+N PGSY C+C +
Sbjct: 1461 CHNLPGL-FRCECEIGYELDRSGGNCTDVNECLDPTTCISGN--CVNTPGSYICDCPPDF 1517
Query: 834 EFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHH---GGSTFSCACLPGYA------ 884
E R C+ + C G C + G S SC C G A
Sbjct: 1518 ELNPTRVGCV--DTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCE 1575
Query: 885 ----------------GDGHQ-------CTDVDECSE--NRCHPAATCYNTPGSFSCRCQ 919
G+G + D+DEC E C C NT GSF CRC
Sbjct: 1576 MCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQ-GGKCINTFGSFQCRCP 1634
Query: 920 PGYY 923
GYY
Sbjct: 1635 TGYY 1638
Score = 71.2 bits (173), Expect = 6e-12
Identities = 66/257 (25%), Positives = 84/257 (32%), Gaps = 69/257 (26%)
Query: 751 VKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQ--GDGRNCVDENECATG 808
+ ++D + C G+ +C G + C+C GY+ DGR CVD NEC
Sbjct: 1922 LSHNNDCIDVDECASGNGNLCRNGQCINTVG-SFQCQCNEGYEVAPDGRTCVDINECLLE 1980
Query: 809 FHRCGPNSVCINLPGSYRCECRSGY-----------EFADDRHTCILIT----------- 846
+C P + C NL GSYRC C GY E ++ C L T
Sbjct: 1981 PRKCAPGT-CQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCL 2039
Query: 847 -PPANPCEDGSHTCAPAGQARCV--HHGGSTFS----------CACLPGYAGDGHQC--- 890
P C + C GG S C C G G C
Sbjct: 2040 CPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELC 2099
Query: 891 --------------------------TDVDECSENRCHPAATCYNTPGSFSCRCQPGYYG 924
D+DEC E C NT GS+ C C GY
Sbjct: 2100 PTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYIL 2159
Query: 925 DGFQCI-PDSTSSLTPC 940
G +C+ D S PC
Sbjct: 2160 AGNECVDTDECSVGNPC 2176
Score = 69.7 bits (169), Expect = 2e-11
Identities = 47/126 (37%), Positives = 63/126 (50%), Gaps = 13/126 (10%)
Query: 800 VDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTC 859
VD +EC C N VCIN+ GS+RCEC G+ + D +L+ + C++G C
Sbjct: 1765 VDIDECREIPGVC-ENGVCINMVGSFRCECPVGFFYNDK----LLVCEDIDECQNGP-VC 1818
Query: 860 APAGQARCVHHGGSTFSCACLPGYA-GDGHQCTDVDECSE--NRCHPAATCYNTPGSFSC 916
A C++ GS + C C PGY QC D +EC E N C C +T GSF C
Sbjct: 1819 --QRNAECINTAGS-YRCDCKPGYRFTSTGQCNDRNECQEIPNIC-SHGQCIDTVGSFYC 1874
Query: 917 RCQPGY 922
C G+
Sbjct: 1875 LCHTGF 1880
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/184 (32%), Positives = 72/184 (39%), Gaps = 33/184 (17%)
Query: 761 NPCYDGSHMCDTTARCHPGTGVDYTCECASG--YQGDGRNCVDENECATGFHRCGPNSVC 818
N C S +CD +C G + C C G Y+ D + C D +EC + C N VC
Sbjct: 767 NECVLNSLLCDN-GQCRNTPG-SFVCTCPKGFIYKPDLKTCEDIDECESS--PC-INGVC 821
Query: 819 INLPGSYRCECRSGYEFADDRHTCILI-------TPPANPCEDG-------SHTCAPAGQ 864
N PGS+ CEC S + CI T CE S C+ G
Sbjct: 822 KNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGA 881
Query: 865 ARCVHHGGSTFSC----ACLPGYAG-DGHQCTDVDECS--ENRCHPAATCYNTPGSFSCR 917
A G C C GY+ G QC D+DEC C C NT GSF C+
Sbjct: 882 A----WGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVC-KNGLCVNTRGSFKCQ 936
Query: 918 CQPG 921
C G
Sbjct: 937 CPSG 940
Score = 60.8 bits (146), Expect = 8e-09
Identities = 56/204 (27%), Positives = 72/204 (35%), Gaps = 39/204 (19%)
Query: 760 GNPCYDGSHMCDTTARCHPGTGVD----YTCECASGYQ--GDGRNCVDENECATGFHRCG 813
G C D C C G ++ + C C G+Q DGR C D NEC T
Sbjct: 567 GKNCEDMDE-CSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETP--GIC 623
Query: 814 PNSVCINLPGSYRCECRSGYEFADDRHTCI----------------LITPPANPCEDGSH 857
N C+N GSYRCEC G D C+ I P
Sbjct: 624 MNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSEC 683
Query: 858 TCAPAGQA------RCVHHGGSTFSCACL--PGYAGDGHQCTDVDECS-ENRCHPAATCY 908
CA A C + + C PG G +D++EC+ + P C
Sbjct: 684 CCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG---SDINECALDPDICPNGICE 740
Query: 909 NTPGSFSCRCQPGYYGD--GFQCI 930
N G++ C C GY D G C+
Sbjct: 741 NLRGTYKCICNSGYEVDSTGKNCV 764
Score = 53.5 bits (127), Expect = 1e-06
Identities = 74/315 (23%), Positives = 104/315 (33%), Gaps = 81/315 (25%)
Query: 763 CYDGSHMCDTTARCHPGTGVDYTCE--CASGYQGDGRNCVDENECATGFHRCGPN----- 815
C +G D C G + + C SG GR CV N CA + GP
Sbjct: 123 CMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGR-CVAPNRCACTYGFTGPQCERDY 181
Query: 816 --SVCINLPGSYRCECR-SGYEFADDR----------HTCILITPPANPCEDG------S 856
C + + C+ + SG H C + +PC G +
Sbjct: 182 RTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRT 241
Query: 857 HTCAPAGQAR----------CVHHGGSTFSCACLPGYAGD--GHQCTDVDECSE--NRCH 902
C + + C++ GS F C C G+ + +C D+DECS C
Sbjct: 242 GACQDVDECQAIPGLCQGGNCINTVGS-FECKCPAGHKLNEVSQKCEDIDECSTIPGICE 300
Query: 903 PAATCYNTPGSFSCRCQPGYY--GDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHI 960
C NT S+ C+C PG+Y DG +CI + Y Y
Sbjct: 301 -GGECTNTVSSYFCKCPPGFYTSPDGTRCI---------------DVRPGYCY--TALTN 342
Query: 961 PQCDEQ--GNFLPLQCHGSTGFCW----CVDPDGHEVPGTQT-------------PPGST 1001
+C Q + +QC G CW V P+ + T+ P
Sbjct: 343 GRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPEYP 402
Query: 1002 PPHCGPSPEPTQRPP 1016
PP GP P PP
Sbjct: 403 PPPLGPIPPVLPVPP 417
Score = 52.8 bits (125), Expect = 2e-06
Identities = 57/202 (28%), Positives = 79/202 (39%), Gaps = 41/202 (20%)
Query: 751 VKEDSDPTP---GNPCYD--GSHMCDTTARCHPGTGVDYT-----------CECASGYQG 794
V E DPT GN C + GS++CD C P ++ T C +G
Sbjct: 1488 VNECLDPTTCISGN-CVNTPGSYICD----CPPDFELNPTRVGCVDTRSGNCYLDIRPRG 1542
Query: 795 DGRNCVDENECATGFHRCG-----------PNSVCINLPGS-YRCECRSGYEFADDRHTC 842
D + NE G + P +C + S Y+ C G F + T
Sbjct: 1543 DNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITV 1602
Query: 843 ILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA--GDGHQCTDVDECSENR 900
IL + C++ C +C++ GS F C C GY D C DV+EC
Sbjct: 1603 IL--EDIDECQELPGLCQGG---KCINTFGS-FQCRCPTGYYLNEDTRVCDDVNECETPG 1656
Query: 901 CHPAATCYNTPGSFSCRCQPGY 922
TCYNT G+++C C P Y
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDY 1678
Score = 52.4 bits (124), Expect = 3e-06
Identities = 48/179 (26%), Positives = 69/179 (38%), Gaps = 43/179 (24%)
Query: 817 VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFS 876
+C PG E +G F D + C +I + C G +C + GS F
Sbjct: 1007 LCPRGPGFATKEITNGKPFFKDINECKMIP---SLCTHG----------KCRNTIGS-FK 1052
Query: 877 CACLPGYAGDGHQ--CTDVDEC--SENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPD 932
C C G+A D + CTD+DEC S + C C NTPG F C+C GY GF + +
Sbjct: 1053 CRCDSGFALDSEERNCTDIDECRISPDLCG-RGQCVNTPGDFECKCDEGYES-GFMMMKN 1110
Query: 933 STSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEV 991
+ C++ + CH + G C P GH++
Sbjct: 1111 CMD-IDECQRDPLLCRGGV----------------------CHNTEGSYRCECPPGHQL 1146
Score = 50.4 bits (119), Expect = 1e-05
Identities = 68/264 (25%), Positives = 91/264 (34%), Gaps = 56/264 (21%)
Query: 784 YTCECASGY--QGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGY-------- 833
+ C C +GY D R C D NEC T CGP + C N G+Y C C Y
Sbjct: 1629 FQCRCPTGYYLNEDTRVCDDVNECETP-GICGPGT-CYNTVGNYTCICPPDYMQVNGGNN 1686
Query: 834 -----------EFADDRHTC---ILITPPANPC----EDGSHTCAPAGQARCVHHGGSTF 875
+ D TC +L C G P Q C F
Sbjct: 1687 CMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQ--CPIPSTDEF 1744
Query: 876 SCAC---LPGYAGDGHQ--CTDVDECSE--NRCHPAATCYNTPGSFSCRCQPG-YYGDGF 927
+ C PG+ D + D+DEC E C C N GSF C C G +Y D
Sbjct: 1745 ATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCE-NGVCINMVGSFRCECPVGFFYNDKL 1803
Query: 928 QCIP--DSTSSLTPCEQQQRHAQAQYAY-----PGARF-HIPQCDEQGNFLPL------- 972
D + C++ +Y PG RF QC+++ +
Sbjct: 1804 LVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHG 1863
Query: 973 QCHGSTGFCWCVDPDGHEVPGTQT 996
QC + G +C+ G + QT
Sbjct: 1864 QCIDTVGSFYCLCHTGFKTNDDQT 1887
Score = 47.4 bits (111), Expect = 1e-04
Identities = 46/175 (26%), Positives = 60/175 (34%), Gaps = 51/175 (29%)
Query: 788 CASGYQG-DGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILIT 846
C GY G C D +EC F N +C+N GS++C+C SG C+ I
Sbjct: 896 CGKGYSRIKGTQCEDIDECEV-FPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954
Query: 847 PPANPC----EDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQC------------ 890
C ED T AG+ R +C C G A +C
Sbjct: 955 --LETCFLRYEDEECTLPIAGRHR-------MDACCCSVGAAWGTEECEECPMRNTPEYE 1005
Query: 891 ---------------------TDVDECS--ENRCHPAATCYNTPGSFSCRCQPGY 922
D++EC + C C NT GSF CRC G+
Sbjct: 1006 ELCPRGPGFATKEITNGKPFFKDINECKMIPSLC-THGKCRNTIGSFKCRCDSGF 1059
Score = 35.8 bits (81), Expect = 0.29
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 488 CEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 523
CE C +HA CT+ A F C C + G+G C
Sbjct: 1326 CEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKC 1361
Score = 30.8 bits (68), Expect = 9.4
Identities = 11/38 (28%), Positives = 19/38 (50%)
Query: 486 ETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 523
+ C + CS+HA C + + C C+ + G+G C
Sbjct: 1365 DECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTC 1402
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,818,631
Number of Sequences: 37866
Number of extensions: 3788916
Number of successful extensions: 19644
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 276
Number of HSP's that attempted gapping in prelim test: 14128
Number of HSP's gapped (non-prelim): 3026
length of query: 1375
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1260
effective length of database: 13,892,928
effective search space: 17505089280
effective search space used: 17505089280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.