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Search of human proteins with 94967023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94967023 disabled homolog 2 interacting protein isoform 1
[Homo sapiens]
(1132 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 2251 0.0
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 2056 0.0
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 1184 0.0
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 1179 0.0
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 1073 0.0
gi|130502162 RAS protein activator like 3 [Homo sapiens] 449 e-126
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 180 8e-45
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 180 8e-45
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 134 5e-31
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 118 3e-26
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 118 4e-26
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 118 4e-26
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 118 4e-26
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 118 4e-26
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 117 6e-26
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 117 6e-26
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 115 2e-25
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 107 8e-23
gi|4759026 RAS protein activator like 1 [Homo sapiens] 106 1e-22
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 54 8e-07
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 51 7e-06
gi|40353727 synaptopodin isoform A [Homo sapiens] 50 1e-05
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 49 3e-05
gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens] 49 3e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 48 5e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 48 5e-05
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 48 5e-05
gi|13129104 coiled-coil domain containing 86 [Homo sapiens] 48 5e-05
gi|157168329 formin 1 [Homo sapiens] 48 6e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 48 6e-05
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 2251 bits (5834), Expect = 0.0
Identities = 1132/1132 (100%), Positives = 1132/1132 (100%)
Query: 1 MEPDSLLDQDDSYESPQERPGSRRSLPGSLSEKSPSMEPSAATPFRVTGFLSRRLKGSIK 60
MEPDSLLDQDDSYESPQERPGSRRSLPGSLSEKSPSMEPSAATPFRVTGFLSRRLKGSIK
Sbjct: 1 MEPDSLLDQDDSYESPQERPGSRRSLPGSLSEKSPSMEPSAATPFRVTGFLSRRLKGSIK 60
Query: 61 RTKSQPKLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALD 120
RTKSQPKLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALD
Sbjct: 61 RTKSQPKLDRNHSFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALD 120
Query: 121 LSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNS 180
LSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNS
Sbjct: 121 LSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNS 180
Query: 181 RRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPL 240
RRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPL
Sbjct: 181 RRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPL 240
Query: 241 RTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMI 300
RTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMI
Sbjct: 241 RTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMI 300
Query: 301 RIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGK 360
RIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGK
Sbjct: 301 RIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGK 360
Query: 361 VKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYES 420
VKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYES
Sbjct: 361 VKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYES 420
Query: 421 DENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRG 480
DENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRG
Sbjct: 421 DENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRG 480
Query: 481 RPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFG 540
RPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFG
Sbjct: 481 RPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFG 540
Query: 541 SKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAV 600
SKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAV
Sbjct: 541 SKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAV 600
Query: 601 SQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIE 660
SQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIE
Sbjct: 601 SQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIE 660
Query: 661 NDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSM 720
NDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSM
Sbjct: 661 NDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSM 720
Query: 721 VDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPT 780
VDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPT
Sbjct: 721 VDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPT 780
Query: 781 TPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAA 840
TPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAA
Sbjct: 781 TPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAA 840
Query: 841 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 900
AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP
Sbjct: 841 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 900
Query: 901 PAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHK 960
PAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHK
Sbjct: 901 PAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHK 960
Query: 961 QGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDK 1020
QGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDK
Sbjct: 961 QGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDK 1020
Query: 1021 LRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMS 1080
LRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMS
Sbjct: 1021 LRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMS 1080
Query: 1081 VEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH 1132
VEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH
Sbjct: 1081 VEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMSALTQLKESMH 1132
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 2056 bits (5327), Expect = 0.0
Identities = 1033/1033 (100%), Positives = 1033/1033 (100%)
Query: 97 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 156
MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC
Sbjct: 1 MPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSC 60
Query: 157 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 216
RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR
Sbjct: 61 RSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKKYLCELCLDDVLYAR 120
Query: 217 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 276
TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR
Sbjct: 121 TTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGR 180
Query: 277 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 336
QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE
Sbjct: 181 QFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALE 240
Query: 337 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 396
PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE
Sbjct: 241 PILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEE 300
Query: 397 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 456
YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN
Sbjct: 301 YLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIIN 360
Query: 457 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 516
SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD
Sbjct: 361 SYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPD 420
Query: 517 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 576
DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT
Sbjct: 421 DRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNT 480
Query: 577 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 636
AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT
Sbjct: 481 AGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGT 540
Query: 637 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 696
NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA
Sbjct: 541 NDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPA 600
Query: 697 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 756
RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG
Sbjct: 601 RSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAG 660
Query: 757 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 816
WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR
Sbjct: 661 WPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPR 720
Query: 817 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 876
GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT
Sbjct: 721 GLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPT 780
Query: 877 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 936
VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS
Sbjct: 781 VPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 840
Query: 937 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 996
TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP
Sbjct: 841 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPP 900
Query: 997 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 1056
HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG
Sbjct: 901 HRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 960
Query: 1057 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1116
EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA
Sbjct: 961 EERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAA 1020
Query: 1117 NARLMSALTQLKE 1129
NARLMSALTQLKE
Sbjct: 1021 NARLMSALTQLKE 1033
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 1184 bits (3064), Expect = 0.0
Identities = 655/1147 (57%), Positives = 827/1147 (72%), Gaps = 81/1147 (7%)
Query: 14 ESPQERPGSRRSLPG-SLSEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRNH 72
E P ER RRS+ G S SEK SM+ + +PF+V GF S+RLKGSIKRTKSQ KLDRN
Sbjct: 153 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 212
Query: 73 SFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPV 132
SFR LP RS ++RS +P+LKESRSHESLLSP S VE LDL E V +KP+
Sbjct: 213 SFR--LPSLRST------DDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPL 264
Query: 133 HSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVI 192
HSSILGQD+CFEVT SGSKCFSC SA+ERDKWMENLRR V PNKDN RR E++L+LW+I
Sbjct: 265 HSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWII 324
Query: 193 EAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETD 252
EAKDL KKKY CELCLDD L+ARTT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +
Sbjct: 325 EAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVE 384
Query: 253 KKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITIL 312
KKKKK++N+Y+GLV++P ASV GRQFVEKWYPV TP P GK GP IRIK+R+QTITIL
Sbjct: 385 KKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITIL 444
Query: 313 PMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSE 372
PME YKEFAE +T++Y LC+ LEP++S + KEE+A ALVHILQSTG+ KDFLTDL+MSE
Sbjct: 445 PMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSE 504
Query: 373 VDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
VDRCG+++ LIFRENT+ATK+IEEYLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS
Sbjct: 505 VDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 564
Query: 433 AADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISAS 492
+++L +HQ NLKMCCELAFCKIINSYCVFPRELKEVFASW+Q+C +RG+ DISERLISAS
Sbjct: 565 SSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISAS 624
Query: 493 LFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQF 552
LFLRFLCPAIMSPSLFNL+QEYPDDRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN F
Sbjct: 625 LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDF 684
Query: 553 LEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLG 612
LEHEW M+RFLLEISNP+T+SNT GF+GYIDLGRELS LHSLLWE VSQL+++ V+KLG
Sbjct: 685 LEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLG 744
Query: 613 PLPRILRDVHTALS--TPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFT 670
PLPR+L D+ +L+ TP QL + S+P + S S+S+GLQK+ + S D
Sbjct: 745 PLPRVLADITKSLTNPTPIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTDS---DLH 800
Query: 671 RLPSPTPENKDLFFVTRS-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTL 729
+L SP+ +N D +F ++ VQ + ++S +YSE +E + + N G+S+S++DLQD
Sbjct: 801 KLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMDLQDTHA- 858
Query: 730 DGEAGSPAGPDVLPTDGQAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPTTPGTS-- 785
Q A ++ P R T +++ +A++++ +T +TP ++
Sbjct: 859 ----------------AQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ 902
Query: 786 -----EGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--SHSNSEEL 838
A +P L PLSFQNPVY + +P P+ DS E S+ S S SNSE+
Sbjct: 903 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF 962
Query: 839 AAAAKLGSFSTAAEELARR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--RRIDQPPP 894
+ G +++ E+ +R E R+ ++ ++ +PRQNS G R++DQ
Sbjct: 963 KLS---GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQ--- 1016
Query: 895 PPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSSSKGDSPE 952
R + PP+L + S ++ SA+ + V +R RQQSSSS+ +SP
Sbjct: 1017 ----GGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSR-ESPV 1071
Query: 953 LKPRAVHKQG----PSPV---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKD 1005
K RA+ +Q SPV + + ++RTAAW+L N Q ED + ++ D
Sbjct: 1072 PKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLN-NGQYEEDV--------EETEQNLD 1122
Query: 1006 ELSQAEK---DLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRR 1062
E AEK ++ L+++LR+S+++LEEYE QE+ QKL+LEY+ARLE+ EERLRR
Sbjct: 1123 EAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRR 1182
Query: 1063 QQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARLMS 1122
QQE+KD QMK IISRLM+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+AN RLMS
Sbjct: 1183 QQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMS 1242
Query: 1123 ALTQLKE 1129
ALTQ+KE
Sbjct: 1243 ALTQVKE 1249
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 1179 bits (3050), Expect = 0.0
Identities = 656/1154 (56%), Positives = 827/1154 (71%), Gaps = 88/1154 (7%)
Query: 14 ESPQERPGSRRSLPG-SLSEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRNH 72
E P ER RRS+ G S SEK SM+ + +PF+V GF S+RLKGSIKRTKSQ KLDRN
Sbjct: 5 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT 64
Query: 73 SFRHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPV 132
SFR LP RS ++RS +P+LKESRSHESLLSP S VE LDL E V +KP+
Sbjct: 65 SFR--LPSLRST------DDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPL 116
Query: 133 HSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVI 192
HSSILGQD+CFEVT SGSKCFSC SA+ERDKWMENLRR V PNKDN RR E++L+LW+I
Sbjct: 117 HSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWII 176
Query: 193 EAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLYRETD 252
EAKDL KKKY CELCLDD L+ARTT K K DN+FWGEHFEF +LPPL ++TVH+Y++ +
Sbjct: 177 EAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVE 236
Query: 253 KKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITIL 312
KKKKK++N+Y+GLV++P ASV GRQFVEKWYPV TP P GK GP IRIK+R+QTITIL
Sbjct: 237 KKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITIL 296
Query: 313 PMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSE 372
PME YKEFAE +T++Y LC+ LEP++S + KEE+A ALVHILQSTG+ KDFLTDL+MSE
Sbjct: 297 PMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSE 356
Query: 373 VDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
VDRCG+++ LIFRENT+ATK+IEEYLKLVGQ+YL DALGEFIKALYESDENCEVDPSKCS
Sbjct: 357 VDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCS 416
Query: 433 AADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISAS 492
+++L +HQ NLKMCCELAFCKIINSYCVFPRELKEVFASW+Q+C +RG+ DISERLISAS
Sbjct: 417 SSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISAS 476
Query: 493 LFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQF 552
LFLRFLCPAIMSPSLFNL+QEYPDDRT+RTLTLIAKV QNLANFAKFG+KEEYM+FMN F
Sbjct: 477 LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDF 536
Query: 553 LEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLE-------Q 605
LEHEW M+RFLLEISNP+T+SNT GF+GYIDLGRELS LHSLLWE VSQL+ Q
Sbjct: 537 LEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQ 596
Query: 606 SIVSKLGPLPRILRDVHTALS--TPGSGQLPGTNDLASTPGSGSSSISAGLQKMVIENDL 663
+ V+KLGPLPR+L D+ +L+ TP QL + S+P + S S+S+GLQK+ +
Sbjct: 597 ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSP-NVSGSLSSGLQKIFEDPTD 655
Query: 664 SGLIDFTRLPSPTPENKDLFFVTRS-SGVQPSPARSSSYSEANEPDLQMANGGKSLSMVD 722
S D +L SP+ +N D +F ++ VQ + ++S +YSE +E + + N G+S+S++D
Sbjct: 656 S---DLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPN-GRSVSLMD 711
Query: 723 LQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARAT--PVNLAGLATVRRAGQTPT 780
LQD Q A ++ P R T +++ +A++++ +T +
Sbjct: 712 LQDTHA-----------------AQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS 754
Query: 781 TPGTS-------EGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLS--S 831
TP ++ A +P L PLSFQNPVY + +P P+ DS E S+ S S
Sbjct: 755 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS 814
Query: 832 HSNSEELAAAAKLGSFSTAAEELARR--PGELARRQMSLTEKGGQPTVPRQNSAGPQ--R 887
SNSE+ + G +++ E+ +R E R+ ++ ++ +PRQNS G R
Sbjct: 815 QSNSEDFKLS---GPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIR 871
Query: 888 RIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASAS--PDWVGPSTRLRQQSSS 945
++DQ R + PP+L + S ++ SA+ + V +R RQQSSS
Sbjct: 872 KVDQ-------GGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSS 924
Query: 946 SKGDSPELKPRAVHKQG----PSPV---SPNALDRTAAWLLTMNAQLLEDEGLGPDPPHR 998
S+ +SP K RA+ +Q SPV + + ++RTAAW+L N Q ED
Sbjct: 925 SR-ESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLN-NGQYEEDV--------E 974
Query: 999 DRLRSKDELSQAEK---DLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEE 1055
+ ++ DE AEK ++ L+++LR+S+++LEEYE QE+ QKL+LEY+ARLE+
Sbjct: 975 ETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLED 1034
Query: 1056 GEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDA 1115
EERLRRQQE+KD QMK IISRLM+VEEELKKDHAEMQA +D+KQKIIDAQEKRI SLD+
Sbjct: 1035 SEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDS 1094
Query: 1116 ANARLMSALTQLKE 1129
AN RLMSALTQ+KE
Sbjct: 1095 ANTRLMSALTQVKE 1108
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 1073 bits (2774), Expect = 0.0
Identities = 610/1222 (49%), Positives = 791/1222 (64%), Gaps = 137/1222 (11%)
Query: 23 RRSLPGSLSEKSPSMEPSAATPFRVT-GFLSRRLKGSIKRTKSQPKLDRNHSFRHILPGF 81
R+S+PG K SME + A PFR + GFLSRRLK SIKRTKSQPKLDR SFR ILP F
Sbjct: 107 RKSVPGG---KQYSMEGAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRF 163
Query: 82 RSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDY 141
RSA D++R+ LM KES SHESLLSPSSA EAL+L+++E+ +IKPVHSSILGQ++
Sbjct: 164 RSA-----DHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEF 218
Query: 142 CFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKK 201
CFEVTTSSG+KCF+CRSAAERDKW+ENL+RAV PNKDNSRRV+++LKLW+IEA++LP KK
Sbjct: 219 CFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKK 278
Query: 202 KYLCELCLDDVLYARTTGKLKT---DNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKE 258
+Y CELCLDD+LYARTT K ++ D VFWGEHFEF+NLP +R + +HLYR++DKK+KK+
Sbjct: 279 RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKD 338
Query: 259 RNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGG--------------------KGPGP 298
+ Y+GLV++P A++AGR F E+WYPV P GG KG P
Sbjct: 339 KAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCP 398
Query: 299 MIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQST 358
+R+KARYQT++ILPME+YKEFAE++TNHY LCA LEP L+ K KEE+ASALVHILQST
Sbjct: 399 AVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQST 458
Query: 359 GKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALY 418
GK KDFL+D+ MSEVDR + EHLIFRENTLATKAIEEY++L+GQKYL+DA+GEFI+ALY
Sbjct: 459 GKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALY 518
Query: 419 ESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSS 478
ES+ENCEVDP KC+A+ L EHQ NL+MCCELA CK++NS+CVFPRELKEVFASWR C+
Sbjct: 519 ESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAE 578
Query: 479 RGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK 538
RGR DI++RLISASLFLRFLCPAIMSPSLF L+QEYPD++T+RTLTLIAKV QNLANF+K
Sbjct: 579 RGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSK 638
Query: 539 FGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWE 598
F SKE+++ FMN+FLE EW +MQ+FL EISN +TL+N++ FEGYIDLGRELS+LH+LLWE
Sbjct: 639 FTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWE 698
Query: 599 AVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPG----SGSSSISAGL 654
+ QL + + KLGPLPR+L D+ TAL P + P P G S+ G
Sbjct: 699 VLPQLSKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGY 758
Query: 655 Q----------KMVIENDLSGLIDFTRLPSPTPE---------NKDLFFVTRSSGVQPSP 695
+ + L+ +D RLPSPT E KDLF+V+R + SP
Sbjct: 759 MMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSP 818
Query: 696 ARSSSYSEANEPDLQMANGGKSLSMVDLQ----DARTLDGEAGSPAGPDVLPTDGQAAAA 751
A +S S+ EP+ +M + KS+SM+DLQ R + A L QA+
Sbjct: 819 AYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLT 878
Query: 752 QLVAGWPARATPVNLAGLATVRRAGQTPTTPG-TSEGAPGRPQLLAPLSFQNPVYQMAAG 810
+ PA A ++ +++ AG + G T++G P + QL PLSFQNP++ MAA
Sbjct: 879 AALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQ-QLRIPLSFQNPLFHMAAD 937
Query: 811 LPLSPRGLGDSGSEGHSSLSSH-------------------------SNSEELAA----- 840
P P G G G GH SSH S SE+L++
Sbjct: 938 GPGPPGGHGGGG--GHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSSGVPKP 995
Query: 841 -AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPP-- 897
AA + + ++E + RRQ+SL + P Q + GPQR P P P
Sbjct: 996 PAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQR----PAPSGPGG 1051
Query: 898 ------------PPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSS 945
PPP RG++ +S Q PRPSSG L + GP+ R RQQS S
Sbjct: 1052 GSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPA-RPRQQSLS 1110
Query: 946 SKGD-----------SPELKPRAV--HKQGPSPVSPN--ALDRTAAWLLTMNAQLLEDEG 990
+G LKP H Q PS ++P A +RT AW+ M + E
Sbjct: 1111 KEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIES 1170
Query: 991 LGPDPPH---RDRLRSKDE-----LSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETT 1042
+ ++ +S DE + + E+++ L+++L +S +KLEEYE QEE T
Sbjct: 1171 AHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQT 1230
Query: 1043 QKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEM-QAAVDSKQK 1101
K++++YQARLE+ E+RLR+QQ +KD Q+K II RLM VEEEL++DH M + + K++
Sbjct: 1231 SKILMQYQARLEQSEKRLRQQQAEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKR 1290
Query: 1102 IIDAQEKRIASLDAANARLMSA 1123
++DAQE+++ L N R+ A
Sbjct: 1291 LLDAQERQLPPLGPTNPRVTLA 1312
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 449 bits (1156), Expect = e-126
Identities = 270/610 (44%), Positives = 360/610 (59%), Gaps = 54/610 (8%)
Query: 105 SHESLLSPSSAVEALDLSMEEEVVIKPVHSSILGQDYCFEVTTSSGSKCFSCRSAAERDK 164
S ESL + S LDL E +V I P+H S+LG+ +CF+VT + GS+CFSCRSAAERD+
Sbjct: 228 SRESLATLSE----LDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDR 283
Query: 165 WMENLRRAVHPNKDNSRRVEHILKLWVIEAKDLPAKKK----YLCELCLDDVLYARTTGK 220
W+E+LRR P +DN R E L +WV EAK LP EL LD L ART +
Sbjct: 284 WIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPR 343
Query: 221 LKTDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSL-------PAASV 273
+FW E F F LPP R +++ L + ++ LG V+L P A
Sbjct: 344 AGPGQLFWAERFHFEALPPARRLSLRL------RGLGPGSAVLGRVALALEELDAPRAPA 397
Query: 274 AGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCA 333
AG +E+W+P++ G G +R + R + + +LP E YKE AE +T HY LC
Sbjct: 398 AG---LERWFPLL------GAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCG 448
Query: 334 ALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKA 393
ALEP L A+ KEE+A+A+V +L++TG+ + +TDL +E+ RCG E L+FRENTLATKA
Sbjct: 449 ALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKA 508
Query: 394 IEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQGNLKMCCELAFCK 453
I+EY+KLV Q YLQ+ LG+ ++ L S E+CEVDPSKC A++LPEHQ L+ CE F
Sbjct: 509 IDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFET 568
Query: 454 IINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQE 513
II+SY FP EL VF+SWR+ C RG + RL+ ASLFLR LCPAI++PSLF L +
Sbjct: 569 IIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPD 628
Query: 514 YPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETL 573
+P ARTLTLIAKV QNLAN A FG KE YM FMN FLE MQ FL +++ +
Sbjct: 629 HPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVD 688
Query: 574 SNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVH----TALSTPG 629
+ +G++G DL +L+ LH+ L ++L+Q+ L PLP ILR + +S P
Sbjct: 689 AAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPM 748
Query: 630 SGQLPGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTP---ENKDLFFVT 686
LP P SS+SAG + G + LP TP +++ L V
Sbjct: 749 RLPLP--------PAQVHSSLSAG--------EKPGFLAPRDLPKHTPLISKSQSLRSVR 792
Query: 687 RS-SGVQPSP 695
RS S +P P
Sbjct: 793 RSESWARPRP 802
Score = 33.1 bits (74), Expect = 1.5
Identities = 58/274 (21%), Positives = 102/274 (37%), Gaps = 51/274 (18%)
Query: 857 RPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQ 916
+PG LA R + P + + S RR + P P R P ++
Sbjct: 766 KPGFLAPRDLPKHT----PLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVP 821
Query: 917 YPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAA 976
RP+ SA P W P + S S G +P +P P P+
Sbjct: 822 VRRPARRR-QSAGP-WPRP------KGSLSMGPAPRARPWT-RDSASLPRKPSV-----P 867
Query: 977 WLLTMNAQLLEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFK 1036
W M+ ++ LG P ++L++ + ++A L+++ ++ ++ +E T +
Sbjct: 868 WQRQMDQPQDRNQALGTHRP-------VNKLAELQCEVAALREEQKVLSRLVESLSTQIR 920
Query: 1037 CQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAV 1096
L E +E+LR Q +D D SRL + E +H
Sbjct: 921 A---------------LTEQQEQLRGQLQDLD-------SRLRAGSSEFDSEHNLTSNEG 958
Query: 1097 DSKQKIIDAQEKRIASLDAANARLMSALTQLKES 1130
S + + E R+ ++ A+L A+ L+ S
Sbjct: 959 HSLKNL----EHRLNEMERTQAQLRDAVQSLQLS 988
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 180 bits (456), Expect = 8e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 132 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 181
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 530 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589
Query: 182 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 238
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 590 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 648
Query: 239 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 297
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 649 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
Query: 298 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 357
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 705 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 762
Query: 358 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 417
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 763 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 821
Query: 418 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 476
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 822 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 881
Query: 477 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 534
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 882 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 941
Query: 535 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 594
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 942 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 1000
Query: 595 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 639
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 1001 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 1046
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 180 bits (456), Expect = 8e-45
Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)
Query: 132 VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 181
VH S+ G+ CF++ S+ F+ + + + WM+ L+ R P N R
Sbjct: 353 VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 412
Query: 182 -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 238
R L L + EA LP K C + L+ V A+T + + N W E F F +LP
Sbjct: 413 LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 471
Query: 239 PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 297
P ++ + T K KK ++ + + + + ++W+ + + P G PG
Sbjct: 472 P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
Query: 298 PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 357
+ R++ARY I+P E Y EF E I L + AL + + + +AS L+ I
Sbjct: 528 SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 585
Query: 358 TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 417
K++ L + D +FR TLA+ +E+Y+K +++ AL + I +
Sbjct: 586 E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 644
Query: 418 YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 476
ES ++CE+ PSK D+ + +L KI + + P L+ ++ ++
Sbjct: 645 MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 704
Query: 477 SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 534
+ + + R++S +FLR +CPAI++P +FN++ + P ARTL L+AK QNLA
Sbjct: 705 QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 764
Query: 535 NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 594
N +FG+KE YM +N F++ M FL E+ N L +T DL R+L++LH
Sbjct: 765 NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 823
Query: 595 LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 639
+ +L +++ ++ G +L+ + T L Q TND+
Sbjct: 824 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 869
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 134 bits (337), Expect = 5e-31
Identities = 111/391 (28%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 216 RTTGKLKTDNVFWGE-----------HFEFHNLPPLRT-VTVHLYRETDKKKKKERNSYL 263
R T + D VF+ E HF+F + + V L+ ++ K E +L
Sbjct: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE---FL 243
Query: 264 GLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMYKE 319
G + +P + E WY + P G K P +R+ Y + + Y
Sbjct: 244 GELRIPLKVLRQSSSYEAWY-FLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSP 302
Query: 320 FAEHITNHYLGLCAALEPILSA---------KTKEEMASALVHILQSTGKVKDFLTDLMM 370
+ + A +EP+ ++ + K+E A LV + G+V F++ +
Sbjct: 303 LRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIAS 357
Query: 371 SEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK 430
+EV R D + IFR N+LA+K I+E +KL G YL L I+ + +S + CE+DP K
Sbjct: 358 AEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK 416
Query: 431 CSAAD-LPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGR--PDISER 487
+ L + NL+ + F I S P + ++F S R+ + R + PD+
Sbjct: 417 LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYT 476
Query: 488 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMS 547
+S+ +FLRF PAI+SP+LF L + D +T+RTLTLI+K Q L + +K S S
Sbjct: 477 AVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKES 536
Query: 548 FMNQFLEHEWTNMQRFLLEISNPETLSNTAG 578
+M F +E+ N Q++ + N L +++G
Sbjct: 537 YMATF--YEFFNEQKYADAVKNFLDLISSSG 565
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 118 bits (296), Expect = 3e-26
Identities = 98/338 (28%), Positives = 164/338 (48%), Gaps = 22/338 (6%)
Query: 262 YLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMY 317
+LG + +P + + WY ++ P G K +R+ Y +LP E Y
Sbjct: 268 FLGEIKVPVNVLRTDSSHQAWY-LLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYY 326
Query: 318 KEFAEHITNH--YLGLCAALEPILS--AKTKEEMASALVHILQSTGKVKDFLTDLMMSEV 373
+ + A+ ILS + K + LV +L K+ F T ++E+
Sbjct: 327 GPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFAT--AVAEL 384
Query: 374 D-RCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCS 432
D + + + IFR N+LAT+ ++E +K+VG YL+ L + + +S ++CE+DP K
Sbjct: 385 DLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK 444
Query: 433 AADLPEH-QGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR--GRPDISERLI 489
D E+ + NL+ + F I+ S P + ++F S RQ + R P + +
Sbjct: 445 EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAV 504
Query: 490 SASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANF-----AKFGSKEE 544
S+ +FLRF A++SP F+L +PD +T RTLTLI+K Q L ++ +K KE
Sbjct: 505 SSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKET 564
Query: 545 YM-SFMNQFLEHEW-TNMQRFLLEISNPETLSNTAGFE 580
+M F F E + +++FL EIS+ ET ++ E
Sbjct: 565 FMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE 602
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 118 bits (295), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 475 VDIEE-------KDELDLQRTLS 490
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 118 bits (295), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.53
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 118 bits (295), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 475 VDIEE-------KDELDLQRTLS 490
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 118 bits (295), Expect = 4e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.53
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 117 bits (293), Expect = 6e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.53
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 117 bits (293), Expect = 6e-26
Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)
Query: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239
L+ V+EA+DL K + D + R G+ + ++ W E FEF
Sbjct: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
Query: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296
L E RN +LG V + + Q E W+ P + + + +G
Sbjct: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
Query: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348
++++ R + T+LP Y+ H+ H + L +E S + ++++A
Sbjct: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
Query: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408
+ L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL
Sbjct: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSMESFLKVAGMQYLHG 366
Query: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453
LG I ++E + E+DPSK CS P+ + L+
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
Query: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509
+ S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+
Sbjct: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
Query: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567
L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++
Sbjct: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKL 546
Query: 568 SNPETLSNTAGFEGYIDLGRELS 590
+ E + +DL R LS
Sbjct: 547 VDIEE-------KDELDLQRTLS 562
Score = 34.7 bits (78), Expect = 0.53
Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241
L + ++E K+LPAK C + +D+ RT KT FWGE ++ H P
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274
V ++ E R+ +G V L ++A
Sbjct: 67 AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 115 bits (288), Expect = 2e-25
Identities = 89/287 (31%), Positives = 146/287 (50%), Gaps = 10/287 (3%)
Query: 329 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 388
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
Query: 389 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 443
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 444 KMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIM 503
E F II+S FP +L+ V Q S R P S + +++FLRF+ PAI+
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF-PQNSIGAVGSAMFLRFINPAIV 1398
Query: 504 SPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSFMNQFLEHEWTNMQRF 563
SP +L + P R R L L++K+ Q++AN F +KEE+M N F++ + +RF
Sbjct: 1399 SPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNFDAARRF 1457
Query: 564 LLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQLEQSIVS 609
L+I++ S+ +I G L +LH LLW ++ Q + S
Sbjct: 1458 FLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEKIGQYLSS 1503
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 107 bits (266), Expect = 8e-23
Identities = 88/307 (28%), Positives = 150/307 (48%), Gaps = 29/307 (9%)
Query: 329 LGLCAALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENT 388
L + AL ++ +E+A LV + S + L ++ EV+ D+ +FR N+
Sbjct: 1221 LPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVE-LADSMQTLFRGNS 1279
Query: 389 LATKAIEEYLKLVGQKYLQDALGEFIKALYESDE----NCEVDPSKCSAAD-LPEHQGNL 443
LA+K + K+ G YLQ L ++ + S + + EVDP++ ++ L E+Q NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 444 KMCCELAFCKIINSYCVFPRELKEV-FASWRQECSS------------RGRPDISERL-- 488
E F II+S FP +L+ V ++ C S + +S+R
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQ 1399
Query: 489 -----ISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKE 543
+ +++FLRF+ PAI+SP +L + P R R L L++K+ Q++AN F +KE
Sbjct: 1400 NSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKE 1458
Query: 544 EYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFE-GYIDLGRELSSLHSLLWEAVSQ 602
E+M N F++ + +RF L+I++ S+ +I G L +LH LLW +
Sbjct: 1459 EHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVL-ALHRLLWNNQEK 1517
Query: 603 LEQSIVS 609
+ Q + S
Sbjct: 1518 IGQYLSS 1524
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 106 bits (264), Expect = 1e-22
Identities = 104/379 (27%), Positives = 169/379 (44%), Gaps = 46/379 (12%)
Query: 222 KTDNVFWGEHFEFHNLP----PLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQ 277
KT W E E +P PLR V L+ + D K N +LG+V ++ +
Sbjct: 174 KTRFPHWDEVLELREMPGAPSPLR---VELW-DWDMVGK---NDFLGMVEFSPKTLQQKP 226
Query: 278 FVEKWYPVVTPNPKGGKGPGP---MIRIKARYQTITILPMEMYKEFAEHITNHYLGLC-- 332
+ W+ ++ P P+ + G +R+K R +LP + Y+ E + G
Sbjct: 227 -PKGWFRLL-PFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEE 284
Query: 333 ------AALEPILSAKTKEEMASALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRE 386
A LE + ++++A+ LV + G FL L EV R D + +FR
Sbjct: 285 DTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD-PNTLFRS 343
Query: 387 NTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAAD---------LP 437
N+LA+K++E+++KLVG YL + L I ++E + E+DP K L
Sbjct: 344 NSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALS 403
Query: 438 EHQ------GNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSR----GRPDISER 487
E Q G L I+ S P ++ F + R D+
Sbjct: 404 EEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYL 463
Query: 488 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK--FGSKEEY 545
IS LFLRF PAI++P LF+L ++ D +T+R+L L+AK Q++ N + KE +
Sbjct: 464 AISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELW 523
Query: 546 MSFMNQFLEHEWTNMQRFL 564
M+ ++ FL + ++ FL
Sbjct: 524 MAPLHPFLLQCVSRVRDFL 542
Score = 31.6 bits (70), Expect = 4.5
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 5/54 (9%)
Query: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFH 235
L + V+E + LPAK C + +DD + ART ++ FWGE + H
Sbjct: 7 LNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 53.9 bits (128), Expect = 8e-07
Identities = 74/301 (24%), Positives = 121/301 (40%), Gaps = 35/301 (11%)
Query: 365 LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYE-SDEN 423
L L+ V D++ LI N +E Y V Q L+ GE K Y+ + E
Sbjct: 981 LRQLLAPVVKEIIDDKSLIINTNP-----VEVYKAWVNQ--LETQTGEASKLPYDVTTEQ 1033
Query: 424 CEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPD 483
P + + NL+ + II+S + P L+ + + + PD
Sbjct: 1034 ALTYPEVKNKLEASIE--NLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKF-PD 1090
Query: 484 ISE----RLISASLFLRFLCPAIMSPSLFNLL------QEYPDDRTARTLTLIAKVTQNL 533
+E +++ L+ R++ PAI++P F+++ Q D R R L +AKV Q+
Sbjct: 1091 ATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHA 1148
Query: 534 ANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLG------- 586
A+ F + E++S MN +L + +++ E N + Y DL
Sbjct: 1149 ASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVI 1208
Query: 587 ----RELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQL-PGTNDLAS 641
E+ S HSLL E + L L L +V T S G G + P + A+
Sbjct: 1209 YISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKAN 1268
Query: 642 T 642
T
Sbjct: 1269 T 1269
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 50.8 bits (120), Expect = 7e-06
Identities = 83/341 (24%), Positives = 130/341 (38%), Gaps = 55/341 (16%)
Query: 695 PARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQA------ 748
P+ S+ EA++ ++++ G + +M + R+ G A S + + + G A
Sbjct: 702 PSNSTRLPEASQAHVRVSPGQAAPAMA--RPRRSRHGPASSSSSSEGEDSAGPARPSQKR 759
Query: 749 ----AAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEG----APGRPQ----LLA 796
A AQ VA W A A+ RA G PG P+ LA
Sbjct: 760 PRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALA 819
Query: 797 PLSFQNPVYQMAAG------LPLS------PRGLGDSGSEGHSSLSSHSNSEELAAA--A 842
P + P + AG +PL+ PRG GD+ +S S S A A
Sbjct: 820 PQAALIPEEECLAGDWLELDMPLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQV 879
Query: 843 KLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNS-AGPQRRIDQPPPPPPPPPP 901
+L + + + P LA +E G P+ PR + +G QP P PPPP
Sbjct: 880 RLTCMQSCSAPVNAGPSSLA------SEPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPI 933
Query: 902 APRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQ 961
R + +L P P S S + W L +Q++ + L PR ++
Sbjct: 934 RVRVQVQDHL---FLIPVPHSSDTHSVA--W------LAEQAAQRYYQTCGLLPRLTLRK 982
Query: 962 GPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLR 1002
+ ++P L +L N ++L + PP DR R
Sbjct: 983 EGALLAPQDL---IPDVLQSNDEVLAEVTSWDLPPLTDRYR 1020
>gi|40353727 synaptopodin isoform A [Homo sapiens]
Length = 903
Score = 50.1 bits (118), Expect = 1e-05
Identities = 77/282 (27%), Positives = 101/282 (35%), Gaps = 48/282 (17%)
Query: 671 RLPSPT-PENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTL 729
R SP P + DL + PSPA + P L + G SL +
Sbjct: 586 RAASPAKPSSLDLVPNLPKGALPPSPALPRP--SRSSPGLYTSPGQDSLQPTAVSP---- 639
Query: 730 DGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEGAP 789
P G D+ P A + P + AG+ R PT+P + GA
Sbjct: 640 ------PYGGDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQDRRESLPTSPPWTPGAS 693
Query: 790 GRPQLLAPLSFQNPVYQMAAGLPLS-------PRGLGDSGSEGHSSLSSHSNSEELAAAA 842
P L P ++ G +S P + S SE S +E +
Sbjct: 694 RPPSSLDGWVSPGP-WEPGRGSSMSSPPPLPPPPPMSPSWSE-RSVSPLRPETEARPPSR 751
Query: 843 KLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPPPA 902
+L + LAR ARR+ + G PR S P R PPPPPPPPPP
Sbjct: 752 QLQAL------LARNIINAARRKSASPRSAGAEN-PRPFS--PPRA---PPPPPPPPPPP 799
Query: 903 PRGRTPPNLLSTLQYPRPSSGTLASA-------SPDWVGPST 937
PR R+P Q RP S + A SP GPS+
Sbjct: 800 PRMRSP-------QPARPGSAAVPGAAFAPIPRSPLPAGPSS 834
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 48.9 bits (115), Expect = 3e-05
Identities = 32/135 (23%), Positives = 68/135 (50%), Gaps = 4/135 (2%)
Query: 999 DRLRSKDELSQA----EKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLE 1054
D + SKD++ ++ EK L+ ++ +LEE E + E+ +L + QA
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 1055 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLD 1114
+ E L+ + E + + K ++ ++ +E EL+ + + AV +++K+ + A +D
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 1115 AANARLMSALTQLKE 1129
+AN A+ QL++
Sbjct: 1628 SANKNRDEAIKQLRK 1642
Score = 38.1 bits (87), Expect = 0.048
Identities = 38/158 (24%), Positives = 82/158 (51%), Gaps = 15/158 (9%)
Query: 986 LEDEGLGPDPPHRDRLRSKDELSQAEKDLAVLQD---KLRISTKKLE----EYETLFKCQ 1038
LE+E +++ ++ +L + E++ +L+D KL K LE E+ T +
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 1039 EETTQ---KLVLEYQARLEEGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAA 1095
EE ++ KL +++A + + EERLRR+++ + +++ +L +L AE+QA
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ-ELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 1096 V-DSKQKIIDAQEK---RIASLDAANARLMSALTQLKE 1129
+ + K ++ +E+ +A ++ A+ AL +++E
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Score = 36.2 bits (82), Expect = 0.18
Identities = 33/130 (25%), Positives = 67/130 (51%), Gaps = 13/130 (10%)
Query: 999 DRLRSKDEL-SQAEKDLAVLQDKLRISTKKLEEYETL---FKCQEETTQKLVLEYQARLE 1054
+RL + L SQ + LQ++L+ T+ E E L +++ +++ + +AR+E
Sbjct: 866 NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVE 925
Query: 1055 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQ----AAVDSKQKIIDAQEKRI 1110
E EER + Q +K K + + +EE+L+++ + Q V ++ K+ +E++I
Sbjct: 926 EEEERCQHLQAEK----KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 1111 ASLDAANARL 1120
L+ N +L
Sbjct: 982 I-LEDQNCKL 990
Score = 31.2 bits (69), Expect = 5.8
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 12/140 (8%)
Query: 998 RDRLRSKDELSQ-AEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEG 1056
R++L ++E EK +A L ++ KK+E+ + EE +KL + + +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 1057 EERLRRQQEDKDIQMKGIISRLMSVEEEL--KKDHAEMQAA-VDSKQKIID---AQEKRI 1110
EE++ +++ +RL ++L DH A ++ KQK D A+EK I
Sbjct: 1402 EEKVAAYD-----KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 1111 ASLDAANARLMSALTQLKES 1130
++ A A + KE+
Sbjct: 1457 SAKYAEERDRAEAEAREKET 1476
Score = 30.8 bits (68), Expect = 7.6
Identities = 27/133 (20%), Positives = 63/133 (47%), Gaps = 13/133 (9%)
Query: 1002 RSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLR 1061
+S + S+ KD + L+ +L+ + + L QEE QKL L + + E E+
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELL---------QEENRQKLSLSTKLKQVEDEKNSF 1341
Query: 1062 RQQ----EDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAAN 1117
R+Q E+ ++ I+ L + ++KK + +++ +++ +K + L +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401
Query: 1118 ARLMSALTQLKES 1130
++A +L+++
Sbjct: 1402 EEKVAAYDKLEKT 1414
>gi|7657387 CCR4-NOT transcription complex, subunit 3 [Homo sapiens]
Length = 753
Score = 48.9 bits (115), Expect = 3e-05
Identities = 82/307 (26%), Positives = 112/307 (36%), Gaps = 55/307 (17%)
Query: 686 TRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMVDLQDART------LDGEAGSPAGP 739
T SS + PSPA ++ E +E D + G + S V A+ + SPA P
Sbjct: 265 TSSSPIPPSPANCTT--ENSEDDKK--RGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVP 320
Query: 740 DVLPTDGQAAAAQLVA-----GWPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGR-PQ 793
P+ AA+ L G PA A P + G + P + G P Q
Sbjct: 321 PTYPSGPPPAASALSTTPGNNGVPAPAAPPSALG-------PKASPAPSHNSGTPAPYAQ 373
Query: 794 LLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEE 853
+AP + P + P G G GS G S SS SNS A K ++ +
Sbjct: 374 AVAPPAPSGPSTTQPRPPSVQPSGGGGGGSGGGGS-SSSSNSSAGGGAGKQNGATSYSSV 432
Query: 854 LARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPP-----PPPPPPPAPRGRTP 908
+A P E+A L+ GG + GP PPP P P G P
Sbjct: 433 VADSPAEVA-----LSSSGGNNA--SSQALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAP 485
Query: 909 --------PNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHK 960
P+LL L PSS T + + G Q S+ +PE+K
Sbjct: 486 GSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFST----APEIK------ 535
Query: 961 QGPSPVS 967
P P+S
Sbjct: 536 -APEPLS 541
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 48.1 bits (113), Expect = 5e-05
Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 16/174 (9%)
Query: 858 PGELARRQMSLTEKGGQ---PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLST 914
PG++ +Q + Q PT P GP + Q P P PPP P PP+
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505
Query: 915 LQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRT 974
P P A SP G + QQ S+K + Q PSP P+A T
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----------QQPSPAKPSAQQST 555
Query: 975 AAWLLTMNAQLLEDEGLGP---DPPHRDRLRSKDELSQAEKDLAVLQDKLRIST 1025
T + + L+ + P PP + ++ L + L + +K +T
Sbjct: 556 KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT 609
Score = 39.7 bits (91), Expect = 0.016
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 892 PPPPPPPPPPAPRGRTPPNLLSTLQYPRPS 921
PPPPPPPPPP P PP L P+P+
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436
Score = 38.5 bits (88), Expect = 0.036
Identities = 14/19 (73%), Positives = 14/19 (73%)
Query: 891 QPPPPPPPPPPAPRGRTPP 909
QPPPPPPPPPP P PP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPP 2422
Score = 37.7 bits (86), Expect = 0.062
Identities = 16/28 (57%), Positives = 16/28 (57%)
Query: 882 SAGPQRRIDQPPPPPPPPPPAPRGRTPP 909
SA P PPPPPPPPPP P PP
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPP 2429
Score = 36.6 bits (83), Expect = 0.14
Identities = 16/35 (45%), Positives = 16/35 (45%)
Query: 875 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPP 909
P PR I PPPPPPPPP P PP
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP 2421
Score = 35.8 bits (81), Expect = 0.24
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 2/88 (2%)
Query: 841 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 900
A++L S S + L +P R S + QP P P PPPPP PPP
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRS--SSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 901 PAPRGRTPPNLLSTLQYPRPSSGTLASA 928
+P+ P T+ P ++ L A
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDA 2458
Score = 35.0 bits (79), Expect = 0.40
Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 12/105 (11%)
Query: 874 QPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP-RPSSGTLASASPDW 932
QPT + + P QP P PP P+ + T++ P +P T A P
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP-- 365
Query: 933 VGPSTRLRQQSSSSKGDSPELKPRAVHK---------QGPSPVSP 968
+GP+ QQ+ S K S + P+A+ + Q P P P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 10/122 (8%)
Query: 815 PRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQ 874
P GL + + G + + S S A S +EE R+ + R L +
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72
Query: 875 PTVPRQNSAGPQRRIDQPPPP-----PPPP-----PPAPRGRTPPNLLSTLQYPRPSSGT 924
P S ++ +D PP PP P P + RT S + P S T
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132
Query: 925 LA 926
++
Sbjct: 133 IS 134
Score = 31.6 bits (70), Expect = 4.5
Identities = 29/116 (25%), Positives = 43/116 (37%), Gaps = 23/116 (19%)
Query: 874 QPTVPRQNSAGPQRRIDQPPPPPPPP---------PPAPRGRTPPNLLSTLQYPRPSSGT 924
Q T P++++A Q P P PPP P+ + + PP S + P +
Sbjct: 680 QQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPS 739
Query: 925 LAS------------ASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 968
+ S P V P+T L SSSS P++ V Q +P
Sbjct: 740 VPSEQDKAPVADDKPKQPKMVKPTTDL--VSSSSATTKPDIPSSKVQSQAEEKTTP 793
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 48.1 bits (113), Expect = 5e-05
Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 16/174 (9%)
Query: 858 PGELARRQMSLTEKGGQ---PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLST 914
PG++ +Q + Q PT P GP + Q P P PPP P PP+
Sbjct: 446 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPG 505
Query: 915 LQYPRPSSGTLASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRT 974
P P A SP G + QQ S+K + Q PSP P+A T
Sbjct: 506 STKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA----------QQPSPAKPSAQQST 555
Query: 975 AAWLLTMNAQLLEDEGLGP---DPPHRDRLRSKDELSQAEKDLAVLQDKLRIST 1025
T + + L+ + P PP + ++ L + L + +K +T
Sbjct: 556 KPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNT 609
Score = 39.7 bits (91), Expect = 0.016
Identities = 16/30 (53%), Positives = 18/30 (60%)
Query: 892 PPPPPPPPPPAPRGRTPPNLLSTLQYPRPS 921
PPPPPPPPPP P PP L P+P+
Sbjct: 2407 PPPPPPPPPPPPPPPPPPPPLPPPTSPKPT 2436
Score = 38.5 bits (88), Expect = 0.036
Identities = 14/19 (73%), Positives = 14/19 (73%)
Query: 891 QPPPPPPPPPPAPRGRTPP 909
QPPPPPPPPPP P PP
Sbjct: 2404 QPPPPPPPPPPPPPPPPPP 2422
Score = 37.7 bits (86), Expect = 0.062
Identities = 16/28 (57%), Positives = 16/28 (57%)
Query: 882 SAGPQRRIDQPPPPPPPPPPAPRGRTPP 909
SA P PPPPPPPPPP P PP
Sbjct: 2402 SAQPPPPPPPPPPPPPPPPPPPPPPLPP 2429
Score = 36.6 bits (83), Expect = 0.14
Identities = 16/35 (45%), Positives = 16/35 (45%)
Query: 875 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPP 909
P PR I PPPPPPPPP P PP
Sbjct: 2387 PAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPP 2421
Score = 35.8 bits (81), Expect = 0.24
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 2/88 (2%)
Query: 841 AAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP 900
A++L S S + L +P R S + QP P P PPPPP PPP
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRS--SSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPP 2430
Query: 901 PAPRGRTPPNLLSTLQYPRPSSGTLASA 928
+P+ P T+ P ++ L A
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDA 2458
Score = 35.0 bits (79), Expect = 0.40
Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 12/105 (11%)
Query: 874 QPTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYP-RPSSGTLASASPDW 932
QPT + + P QP P PP P+ + T++ P +P T A P
Sbjct: 308 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP-- 365
Query: 933 VGPSTRLRQQSSSSKGDSPELKPRAVHK---------QGPSPVSP 968
+GP+ QQ+ S K S + P+A+ + Q P P P
Sbjct: 366 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP 410
Score = 31.6 bits (70), Expect = 4.5
Identities = 28/122 (22%), Positives = 43/122 (35%), Gaps = 10/122 (8%)
Query: 815 PRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQ 874
P GL + + G + + S S A S +EE R+ + R L +
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP 72
Query: 875 PTVPRQNSAGPQRRIDQPPPP-----PPPP-----PPAPRGRTPPNLLSTLQYPRPSSGT 924
P S ++ +D PP PP P P + RT S + P S T
Sbjct: 73 PAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPST 132
Query: 925 LA 926
++
Sbjct: 133 IS 134
Score = 31.6 bits (70), Expect = 4.5
Identities = 29/116 (25%), Positives = 43/116 (37%), Gaps = 23/116 (19%)
Query: 874 QPTVPRQNSAGPQRRIDQPPPPPPPP---------PPAPRGRTPPNLLSTLQYPRPSSGT 924
Q T P++++A Q P P PPP P+ + + PP S + P +
Sbjct: 680 QQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPS 739
Query: 925 LAS------------ASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 968
+ S P V P+T L SSSS P++ V Q +P
Sbjct: 740 VPSEQDKAPVADDKPKQPKMVKPTTDL--VSSSSATTKPDIPSSKVQSQAEEKTTP 793
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 48.1 bits (113), Expect = 5e-05
Identities = 84/315 (26%), Positives = 119/315 (37%), Gaps = 46/315 (14%)
Query: 603 LEQSIVSKLGPLPRILRDVHTALSTPGSGQLP-GTNDLASTPGSGSSSISAGLQKMVIEN 661
L S L PLP +L A S Q P +STPG+ +S S +
Sbjct: 1598 LAPSPAPPLAPLP-VLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPV-- 1654
Query: 662 DLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMANGGKSLSMV 721
L+ T LP+P P P P+ +S+ + A P L GG S S
Sbjct: 1655 -LAPSSTQTMLPAPVPS--------------PLPSPASTQTLALAPALAPTLGGSSPS-- 1697
Query: 722 DLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAG------LATVRRA 775
+TL G+P GP T A+ LV P A ++LA T+ A
Sbjct: 1698 -----QTLSLGTGNPQGPFPTQTLSLTPASSLV---PTPAQTLSLAPGPPLGPTQTLSLA 1749
Query: 776 GQTPTTPGTSEG-APGRPQLLAPLSFQNPVYQMAA--GLPLSPRGLGDSGSEGHSSLSSH 832
P P + G AP LAP S + A+ L LSP + G +L+
Sbjct: 1750 PAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALA 1809
Query: 833 SNSEELAAAAKLGSFSTAAEELARRPGELARRQM-------SLTEKGGQPTVPRQNSAGP 885
S + + A++ S +A A P + R +LT + G P+ P ++
Sbjct: 1810 PASTQ-SPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFG 1868
Query: 886 QRRIDQPPPPPPPPP 900
R + PPPPP P
Sbjct: 1869 GPRPRRQPPPPPRSP 1883
Score = 39.3 bits (90), Expect = 0.021
Identities = 92/361 (25%), Positives = 124/361 (34%), Gaps = 83/361 (22%)
Query: 634 PGTNDLASTPGSGSSSISAGLQKMVIENDLSGLIDFTRLPSPTPENKDL-------FFVT 686
P AS PG+ +IS+ L + + L G P P P + L V
Sbjct: 1381 PSPEVSASAPGAAPLTISSPLH---VPSSLPGPASS---PMPIPNSSPLASPVSSTVSVP 1434
Query: 687 RSSGVQ-------PSPARSSSYSEANEPDLQMANGGKSLSMVDLQDARTLDGEAGSPAGP 739
SS + P+PA + + P A+G L+ V A + +P P
Sbjct: 1435 LSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPA---APGPP 1491
Query: 740 DVLPTDGQAAAAQLVAGWPARATPVNLAGLATVRRAGQTPTTPGTSEGAPGRPQLLAPLS 799
+ P+ +A+ L G LAT + T PG P LLAP S
Sbjct: 1492 SLAPSGASPSASALTLG------------LATAPSLSSSQT--------PGHPLLLAPTS 1531
Query: 800 FQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSHSNSEELAAAAKLGSFSTAAEELARRPG 859
P G +S + + S L A+ L S +A A
Sbjct: 1532 SHVP---------------------GLNSTVAPACSPVLVPASALASPFPSAPNPAPAQA 1570
Query: 860 ELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQPPPPPPPPP---PAPRGRTPPNLLST-- 914
L S ++ P P A PQ I P P PP P AP P L S+
Sbjct: 1571 SLLAPASSASQALATPLAP---MAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQT 1627
Query: 915 ---LQYPRPSSGT-LASASPDWVGPSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNA 970
+ P + GT LASASP V T + SS+ + P V PSP S
Sbjct: 1628 PVPVMAPSSTPGTSLASASP--VPAPTPVLAPSSTQ-----TMLPAPVPSPLPSPASTQT 1680
Query: 971 L 971
L
Sbjct: 1681 L 1681
>gi|13129104 coiled-coil domain containing 86 [Homo sapiens]
Length = 360
Score = 48.1 bits (113), Expect = 5e-05
Identities = 82/349 (23%), Positives = 129/349 (36%), Gaps = 58/349 (16%)
Query: 773 RRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSSLSSH 832
R G P+ G+P RP +P S P Q AGL SP+G + G+
Sbjct: 43 REPGSPPSVQRAGLGSPERPPKTSPGS---PRLQQGAGLE-SPQGQPEPGAAS----PQR 94
Query: 833 SNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQRRIDQP 892
L + + +S + +P E A + + P Q
Sbjct: 95 QQDLHLESPQRQPEYSPESPRCQPKPSEEAPKCSQDQGVLASELAQNKEELTPGAPQHQL 154
Query: 893 PPPPPPPPPAPRGRTP------PNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSSSS 946
PP P P P P + P P L T + P G + P G + +
Sbjct: 155 PPVPGSPEPYPGQQAPGPEPSQPLLELTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKR 214
Query: 947 KGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLRSKDE 1006
KG S + + PV P ++ ++ +D RSK
Sbjct: 215 KGSSSQAPASKKLNKEELPVIPKGKPKSG--------RVWKD-------------RSKKR 253
Query: 1007 LSQAEKDLAVLQDK-LRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQE 1065
SQ +LQDK LR S ++ K +E +KL ++ LEE +E RR+QE
Sbjct: 254 FSQ------MLQDKPLRTSWQR--------KMKERQERKLAKDFARHLEEEKE--RRRQE 297
Query: 1066 DKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLD 1114
K + + + RL E E K AE+ + + K+ A++K++ S++
Sbjct: 298 KKQRRAENLKRRL---ENERK---AEVVQVIRNPAKLKRAKKKQLRSIE 340
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 47.8 bits (112), Expect = 6e-05
Identities = 61/245 (24%), Positives = 99/245 (40%), Gaps = 30/245 (12%)
Query: 875 PTVPRQNSAGPQRRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVG 934
P +P +SAGP PPPPPPPP P PPN P P LA P
Sbjct: 688 PPLPPPSSAGP--------PPPPPPPPLPNSPAPPNPGGPPPAPPPPG--LAPPPP---- 733
Query: 935 PSTRLRQQSSSSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNA-----QLLEDE 989
P SSSS+ PR + P+ P R + NA LE+
Sbjct: 734 PGLFFGLGSSSSQ------CPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEP 787
Query: 990 GLGPDPPHRDRLRSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEY 1049
+ DP + L SKD Q +K L+ +K + KK+ + L + +T L+
Sbjct: 788 DI-RDPSEFEYLFSKDTTQQKKKPLSETYEK-KNKVKKI--IKLLDGKRSQTVGILISSL 843
Query: 1050 QARLEEGEERLRRQQED-KDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEK 1108
+++ ++ + + D++ + + E+EL K + + + + K++D E+
Sbjct: 844 HLEMKDIQQAIFNVDDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQ 903
Query: 1109 RIASL 1113
+ L
Sbjct: 904 FLHEL 908
Score = 30.8 bits (68), Expect = 7.6
Identities = 27/92 (29%), Positives = 37/92 (40%), Gaps = 9/92 (9%)
Query: 878 PRQNSAGPQRRIDQPPPPP-PPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPS 936
P + A Q++ PPP PPPPP P G L +L P P +++ P P
Sbjct: 633 PMEGMASNQQKALPPPPASIPPPPPLPSG------LGSLS-PAPPMPPVSAGPPLPPPPP 685
Query: 937 TRLRQQSSSSKGDSPELKPRAVHKQGPSPVSP 968
SS G P P + P+P +P
Sbjct: 686 PPPPLPPPSSAGPPPPPPPPPL-PNSPAPPNP 716
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 47.8 bits (112), Expect = 6e-05
Identities = 35/136 (25%), Positives = 69/136 (50%), Gaps = 6/136 (4%)
Query: 999 DRLRSKDELS----QAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLE 1054
D + SKD++ + EK L+ ++ +LEE E + E+ +L + QA
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 1055 EGEERLRRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKI-IDAQEKRIASL 1113
+ E L+ + E + + + +I ++ +E EL+ + + AV SK+K+ ID ++ A +
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE-AQI 1633
Query: 1114 DAANARLMSALTQLKE 1129
+AAN + QL++
Sbjct: 1634 EAANKARDEVIKQLRK 1649
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/110 (26%), Positives = 60/110 (54%), Gaps = 10/110 (9%)
Query: 1012 KDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQAR-LEEGEERLRRQQEDKDIQ 1070
KD A L+ +L+ + + L QEET QKL L + R LEE + L+ QQE+++
Sbjct: 1308 KDAASLESQLQDTQELL---------QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 1071 MKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANARL 1120
K + ++++++ +L ++ + + + + +A++K + +A + RL
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408
Score = 33.1 bits (74), Expect = 1.5
Identities = 31/141 (21%), Positives = 65/141 (46%), Gaps = 13/141 (9%)
Query: 1002 RSKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQ--------ARL 1053
R ++EL +++L +++K +LEE E K Q+ +K +L Q A
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMER--KHQQLLEEKNILAEQLQAETELFAEA 906
Query: 1054 EEGEERLRRQQEDKDIQMKGIISRLMSVEEE---LKKDHAEMQAAVDSKQKIIDAQEKRI 1110
EE RL ++++ + + + SR+ EE L+ + +MQA + ++ +D +E
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 1111 ASLDAANARLMSALTQLKESM 1131
L + + +++E +
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEI 987
Score = 31.2 bits (69), Expect = 5.8
Identities = 23/112 (20%), Positives = 58/112 (51%), Gaps = 10/112 (8%)
Query: 1016 VLQDKLRISTK---KLEEYETLFKCQEETTQKLVLEYQARLEEGEERLRRQQEDKDIQMK 1072
+L ++L+ T+ + EE +++ ++++ + ++R+EE EER + Q +K K
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK----K 946
Query: 1073 GIISRLMSVEEELKKDHA---EMQAAVDSKQKIIDAQEKRIASLDAANARLM 1121
+ + + +EE+L ++ ++Q + + I E+ I L+ N++ +
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFI 998
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,430,719
Number of Sequences: 37866
Number of extensions: 2800079
Number of successful extensions: 35397
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 524
Number of HSP's successfully gapped in prelim test: 1335
Number of HSP's that attempted gapping in prelim test: 18119
Number of HSP's gapped (non-prelim): 9954
length of query: 1132
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1019
effective length of database: 13,968,660
effective search space: 14234064540
effective search space used: 14234064540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.