Search of human proteins with 93587342

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93587342 voltage-gated sodium channel type 4 alpha [Homo
sapiens]
         (1836 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  3734   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  1869   0.0  
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  1869   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  1869   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  1846   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  1817   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  1817   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  1817   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  1811   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  1803   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  1748   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  1734   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  1731   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  1731   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  1686   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  1665   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1605   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1605   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  1557   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1033   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   442   e-123
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...   437   e-122
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...   331   3e-90
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...   331   5e-90
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...   331   5e-90

>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 3734 bits (9683), Expect = 0.0
 Identities = 1836/1836 (100%), Positives = 1836/1836 (100%)

Query: 1    MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEA 60
            MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEA
Sbjct: 1    MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEA 60

Query: 61   GKNLPMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVV 120
            GKNLPMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVV
Sbjct: 61   GKNLPMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVV 120

Query: 121  RRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARG 180
            RRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARG
Sbjct: 121  RRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARG 180

Query: 181  FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIV 240
            FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIV
Sbjct: 181  FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIV 240

Query: 241  GALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTW 300
            GALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTW
Sbjct: 241  GALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTW 300

Query: 301  YGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLC 360
            YGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLC
Sbjct: 301  YGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLC 360

Query: 361  GNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG 420
            GNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG
Sbjct: 361  GNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG 420

Query: 421  KTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQE 480
            KTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQE
Sbjct: 421  KTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQE 480

Query: 481  ELEKAKAAQALEGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEA 540
            ELEKAKAAQALEGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEA
Sbjct: 481  ELEKAKAAQALEGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEA 540

Query: 541  HQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHY 600
            HQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHY
Sbjct: 541  HQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHY 600

Query: 601  PMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLA 660
            PMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLA
Sbjct: 601  PMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLA 660

Query: 661  NVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 720
            NVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ
Sbjct: 661  NVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQ 720

Query: 721  LFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLT 780
            LFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLT
Sbjct: 721  LFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLT 780

Query: 781  VFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFL 840
            VFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFL
Sbjct: 781  VFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFL 840

Query: 841  LGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLA 900
            LGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLA
Sbjct: 841  LGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLA 900

Query: 901  DGPPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDG 960
            DGPPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDG
Sbjct: 901  DGPPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDG 960

Query: 961  NSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTL 1020
            NSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTL
Sbjct: 961  NSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTL 1020

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM
Sbjct: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080

Query: 1081 LLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRAL 1140
            LLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRAL
Sbjct: 1081 LLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRAL 1140

Query: 1141 SRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDI 1200
            SRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDI
Sbjct: 1141 SRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDI 1200

Query: 1201 SEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKE 1260
            SEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKE
Sbjct: 1201 SEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKE 1260

Query: 1261 EQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYY 1320
            EQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYY
Sbjct: 1261 EQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYY 1320

Query: 1321 NAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQL 1380
            NAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQL
Sbjct: 1321 NAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQL 1380

Query: 1381 KVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKY 1440
            KVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKY
Sbjct: 1381 KVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKY 1440

Query: 1441 FVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1500
            FVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG
Sbjct: 1441 FVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1500

Query: 1501 MSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENP 1560
            MSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENP
Sbjct: 1501 MSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENP 1560

Query: 1561 GTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMF 1620
            GTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMF
Sbjct: 1561 GTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMF 1620

Query: 1621 YETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDIL 1680
            YETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDIL
Sbjct: 1621 YETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDIL 1680

Query: 1681 FALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRR 1740
            FALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRR
Sbjct: 1681 FALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRR 1740

Query: 1741 HLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNSSSPSPEEKGEAGD 1800
            HLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNSSSPSPEEKGEAGD
Sbjct: 1741 HLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGHENGNSSSPSPEEKGEAGD 1800

Query: 1801 AGPTMGLMPISPSDTAWPPAPPPGQTVRPGVKESLV 1836
            AGPTMGLMPISPSDTAWPPAPPPGQTVRPGVKESLV
Sbjct: 1801 AGPTMGLMPISPSDTAWPPAPPPGQTVRPGVKESLV 1836


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 1869 bits (4842), Expect = 0.0
 Identities = 938/1257 (74%), Positives = 1067/1257 (84%), Gaps = 19/1257 (1%)

Query: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
            +++ MEELEE+ QKCPP WYK A+  LIW+CC PWLK K++++L+VMDPFVDL ITICIV
Sbjct: 711  LTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV 770

Query: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            LNTLFMAMEHYPMTE F +VL+VGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 771  LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 830

Query: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
            V+LSL+ELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 831  VSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890

Query: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769
            IVFIFAVVGMQLFGKSYKECVCKI+ DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 891  IVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 950

Query: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829
            MEVAGQ MCLTVF+MVMVIGNLVVLNLFLALLLSSFS+D+LAA+D+D EMNNLQIA+GR+
Sbjct: 951  MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1010

Query: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889
            + GI F K  +   +    +  +    +L E     +     ++   +       +DL  
Sbjct: 1011 QKGIDFVKRKIREFIQKAFVRKQK---ALDEIKPLEDLNNKKDSCISNHTTIEIGKDL-- 1065

Query: 890  DNHILNHMGLADGPPSSL------ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDT 943
             N++ +  G   G  SS+      E D+++FINNP LT+ VPIA  ESD E    EE  +
Sbjct: 1066 -NYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSS 1124

Query: 944  FSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRW 1002
             S+ E+SK   + L   +SS  ST D   P E   EQ E  PE   +PE CFTE CV+++
Sbjct: 1125 ESDMEESK---EKLNATSSSEGSTVDIGAPAEG--EQPEVEPEESLEPEACFTEDCVRKF 1179

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIR 1062
             C  + I +G+GK WW LR+ C+KIVEHNWFETFIVFMILLSSGALAFEDIYIEQR+ I+
Sbjct: 1180 KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239

Query: 1063 TILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSEL 1122
            T+LEYADKVFTYIFI+EMLLKWVAYGF+VYFTNAWCWLDFLIVDVS++SL AN LGYSEL
Sbjct: 1240 TMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1299

Query: 1123 GPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1182
            G IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF
Sbjct: 1300 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1359

Query: 1183 AGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLGYLSLLQVA 1241
            AGKFY+CIN TT E FD+S VNN SEC++L+ + Q  RW NVKVN+DNVGLGYLSLLQVA
Sbjct: 1360 AGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419

Query: 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
            TFKGWMDIMYAAVDSR  E QP+YE NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479

Query: 1302 KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
            KKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VTKQ FDI+IMI
Sbjct: 1480 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI 1539

Query: 1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDF 1421
            LICLNMVTMMVETD+QSQ   +ILY IN++FI++FTGECVLK+++LR YYFT+GWNIFDF
Sbjct: 1540 LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDF 1599

Query: 1422 VVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPA 1481
            VVVILSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPA
Sbjct: 1600 VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1659

Query: 1482 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL 1541
            LFNIGLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGL
Sbjct: 1660 LFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGL 1719

Query: 1542 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601
            L PILNSGPPDCDP+ ++PG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF
Sbjct: 1720 LAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779

Query: 1602 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL 1661
            +VATEES+EPL EDDFEMFYE WEKFDPDATQFI +++LSDF D L  PL IAKPNK++L
Sbjct: 1780 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL 1839

Query: 1662 ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTT 1721
            I +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSYEPITTT
Sbjct: 1840 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTT 1899

Query: 1722 LKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778
            LKRK EEV AI IQRAYRR+LL++ +K+ S +Y+       D  P KE  L + +++
Sbjct: 1900 LKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNE 1956



 Score =  697 bits (1799), Expect = 0.0
 Identities = 351/491 (71%), Positives = 407/491 (82%), Gaps = 21/491 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEA-RLQRNKQMEIEEPERKPRSDLEAGKNLPMI 67
           LVP GP+  R FTRESLAAIEQR  EE+A R ++ ++ E +E   KP SDLEAGK+LP I
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65

Query: 68  YGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKV 127
           YGD PPE++ +PLEDLDPYY NKKTFIVLNKGKAI RFSATPALY+L+PF+ +R+ AIK+
Sbjct: 66  YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125

Query: 128 LIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFT 187
           L+H+LF+M IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFT
Sbjct: 126 LVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFT 185

Query: 188 FLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSV 247
           FLRDPWNWLDF+VI  AY+TEFV+LGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSV
Sbjct: 186 FLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 245

Query: 248 KKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWY 307
           KKLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP     N+++  N T + N++  
Sbjct: 246 KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSLD 301

Query: 308 GNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAG 367
           GN             T+N      T   F+WD YI D+ +FYFLEG NDALLCGNSSDAG
Sbjct: 302 GN-----------GTTFN-----RTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG 345

Query: 368 HCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFF 427
            CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMIFF
Sbjct: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFF 405

Query: 428 VVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKA 487
           V++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE + A A
Sbjct: 406 VLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAA 465

Query: 488 AQALEGGEADG 498
           A + E  +  G
Sbjct: 466 AASAESRDFSG 476



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 79/340 (23%), Positives = 146/340 (42%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 118  IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 169

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++  + ++   N      LG + +LRT R LR
Sbjct: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVN------LGNVSALRTFRVLR 223

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G     C+    
Sbjct: 224  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 283

Query: 1191 -------------------NTTTSER----FDISE-VNNKSE------------CESLMH 1214
                               N TT  R    F+  E + +KS             C +   
Sbjct: 284  DNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSD 343

Query: 1215 TGQV--RWLNVK---------VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK          ++D     +LSL ++ T   W ++    + +  K    
Sbjct: 344  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 399

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 400  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+   K++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF V    +  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 46/173 (26%), Positives = 88/173 (50%), Gaps = 12/173 (6%)

Query: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
           P+   + +   I++    ++ I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 167

Query: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
            E ++K++A    ++ + + +  WN  D  ++T + V     N+  +S LR+FR+LR  K
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-EFVNLGNVSALRTFRVLRALK 226

Query: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
                P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 12/173 (6%)

Query: 116 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYT 169
           P+  V+     V++     + I I I+ N +FM M   P   +           FTGI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALK 228
            E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
                P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 19/73 (26%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI-FFVVIIFLGSFYLINLILAVVAMAY 450
           F  +FL +FR++  ++ E ++   +  AG+T  +  F++++ +G+  ++NL LA++  ++
Sbjct: 928 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986

Query: 451 AEQNEATLAEDKE 463
           +  N A   +D E
Sbjct: 987 SSDNLAATDDDNE 999



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLF---------QLTLRAAGKTYM-IFFVVIIFLGSFY 437
            ++D     +L+L ++ T   W ++          +L  +     YM ++FV+ I  GSF+
Sbjct: 1404 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFF 1463

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1464 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 430 EQNQATLEE 438


>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 1869 bits (4842), Expect = 0.0
 Identities = 938/1257 (74%), Positives = 1067/1257 (84%), Gaps = 19/1257 (1%)

Query: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
            +++ MEELEE+ QKCPP WYK A+  LIW+CC PWLK K++++L+VMDPFVDL ITICIV
Sbjct: 711  LTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV 770

Query: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            LNTLFMAMEHYPMTE F +VL+VGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 771  LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 830

Query: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
            V+LSL+ELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 831  VSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890

Query: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769
            IVFIFAVVGMQLFGKSYKECVCKI+ DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 891  IVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 950

Query: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829
            MEVAGQ MCLTVF+MVMVIGNLVVLNLFLALLLSSFS+D+LAA+D+D EMNNLQIA+GR+
Sbjct: 951  MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1010

Query: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889
            + GI F K  +   +    +  +    +L E     +     ++   +       +DL  
Sbjct: 1011 QKGIDFVKRKIREFIQKAFVRKQK---ALDEIKPLEDLNNKKDSCISNHTTIEIGKDL-- 1065

Query: 890  DNHILNHMGLADGPPSSL------ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDT 943
             N++ +  G   G  SS+      E D+++FINNP LT+ VPIA  ESD E    EE  +
Sbjct: 1066 -NYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSS 1124

Query: 944  FSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRW 1002
             S+ E+SK   + L   +SS  ST D   P E   EQ E  PE   +PE CFTE CV+++
Sbjct: 1125 ESDMEESK---EKLNATSSSEGSTVDIGAPAEG--EQPEVEPEESLEPEACFTEDCVRKF 1179

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIR 1062
             C  + I +G+GK WW LR+ C+KIVEHNWFETFIVFMILLSSGALAFEDIYIEQR+ I+
Sbjct: 1180 KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239

Query: 1063 TILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSEL 1122
            T+LEYADKVFTYIFI+EMLLKWVAYGF+VYFTNAWCWLDFLIVDVS++SL AN LGYSEL
Sbjct: 1240 TMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1299

Query: 1123 GPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1182
            G IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF
Sbjct: 1300 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1359

Query: 1183 AGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLGYLSLLQVA 1241
            AGKFY+CIN TT E FD+S VNN SEC++L+ + Q  RW NVKVN+DNVGLGYLSLLQVA
Sbjct: 1360 AGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419

Query: 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
            TFKGWMDIMYAAVDSR  E QP+YE NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479

Query: 1302 KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
            KKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VTKQ FDI+IMI
Sbjct: 1480 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI 1539

Query: 1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDF 1421
            LICLNMVTMMVETD+QSQ   +ILY IN++FI++FTGECVLK+++LR YYFT+GWNIFDF
Sbjct: 1540 LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDF 1599

Query: 1422 VVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPA 1481
            VVVILSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPA
Sbjct: 1600 VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1659

Query: 1482 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL 1541
            LFNIGLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGL
Sbjct: 1660 LFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGL 1719

Query: 1542 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601
            L PILNSGPPDCDP+ ++PG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF
Sbjct: 1720 LAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779

Query: 1602 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL 1661
            +VATEES+EPL EDDFEMFYE WEKFDPDATQFI +++LSDF D L  PL IAKPNK++L
Sbjct: 1780 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL 1839

Query: 1662 ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTT 1721
            I +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSYEPITTT
Sbjct: 1840 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTT 1899

Query: 1722 LKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778
            LKRK EEV AI IQRAYRR+LL++ +K+ S +Y+       D  P KE  L + +++
Sbjct: 1900 LKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNE 1956



 Score =  699 bits (1804), Expect = 0.0
 Identities = 352/491 (71%), Positives = 407/491 (82%), Gaps = 21/491 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEA-RLQRNKQMEIEEPERKPRSDLEAGKNLPMI 67
           LVP GP+  R FTRESLAAIEQR  EE+A R ++ ++ E +E   KP SDLEAGK+LP I
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65

Query: 68  YGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKV 127
           YGD PPE++ +PLEDLDPYY NKKTFIVLNKGKAI RFSATPALY+L+PF+ +R+ AIK+
Sbjct: 66  YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125

Query: 128 LIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFT 187
           L+H+LF+M IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFT
Sbjct: 126 LVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFT 185

Query: 188 FLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSV 247
           FLRDPWNWLDF+VI  AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSV
Sbjct: 186 FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 245

Query: 248 KKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWY 307
           KKLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP     N+++  N T + N++  
Sbjct: 246 KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSLD 301

Query: 308 GNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAG 367
           GN             T+N      T   F+WD YI D+ +FYFLEG NDALLCGNSSDAG
Sbjct: 302 GN-----------GTTFN-----RTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG 345

Query: 368 HCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFF 427
            CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMIFF
Sbjct: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFF 405

Query: 428 VVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKA 487
           V++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE + A A
Sbjct: 406 VLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAA 465

Query: 488 AQALEGGEADG 498
           A + E  +  G
Sbjct: 466 AASAESRDFSG 476



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 78/340 (22%), Positives = 147/340 (43%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 118  IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 169

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++  + ++       + +LG + +LRT R LR
Sbjct: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 223

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G     C+    
Sbjct: 224  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 283

Query: 1191 -------------------NTTTSER----FDISE-VNNKSE------------CESLMH 1214
                               N TT  R    F+  E + +KS             C +   
Sbjct: 284  DNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSD 343

Query: 1215 TGQV--RWLNVK---------VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK          ++D     +LSL ++ T   W ++    + +  K    
Sbjct: 344  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 399

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 400  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+   K++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF V    +  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 12/173 (6%)

Query: 116 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYT 169
           P+  V+     V++     + I I I+ N +FM M   P   +           FTGI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALK 228
            E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
                P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 45/173 (26%), Positives = 88/173 (50%), Gaps = 12/173 (6%)

Query: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
           P+   + +   I++    ++ I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 167

Query: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
            E ++K++A    ++ + + +  WN  D  ++T + V     ++  +S LR+FR+LR  K
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-EFVDLGNVSALRTFRVLRALK 226

Query: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
                P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 19/73 (26%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI-FFVVIIFLGSFYLINLILAVVAMAY 450
           F  +FL +FR++  ++ E ++   +  AG+T  +  F++++ +G+  ++NL LA++  ++
Sbjct: 928 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986

Query: 451 AEQNEATLAEDKE 463
           +  N A   +D E
Sbjct: 987 SSDNLAATDDDNE 999



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLF---------QLTLRAAGKTYM-IFFVVIIFLGSFY 437
            ++D     +L+L ++ T   W ++          +L  +     YM ++FV+ I  GSF+
Sbjct: 1404 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFF 1463

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1464 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 430 EQNQATLEE 438


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 1869 bits (4842), Expect = 0.0
 Identities = 938/1257 (74%), Positives = 1067/1257 (84%), Gaps = 19/1257 (1%)

Query: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
            +++ MEELEE+ QKCPP WYK A+  LIW+CC PWLK K++++L+VMDPFVDL ITICIV
Sbjct: 711  LTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV 770

Query: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            LNTLFMAMEHYPMTE F +VL+VGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 771  LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 830

Query: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
            V+LSL+ELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 831  VSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890

Query: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769
            IVFIFAVVGMQLFGKSYKECVCKI+ DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 891  IVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 950

Query: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829
            MEVAGQ MCLTVF+MVMVIGNLVVLNLFLALLLSSFS+D+LAA+D+D EMNNLQIA+GR+
Sbjct: 951  MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1010

Query: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889
            + GI F K  +   +    +  +    +L E     +     ++   +       +DL  
Sbjct: 1011 QKGIDFVKRKIREFIQKAFVRKQK---ALDEIKPLEDLNNKKDSCISNHTTIEIGKDL-- 1065

Query: 890  DNHILNHMGLADGPPSSL------ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDT 943
             N++ +  G   G  SS+      E D+++FINNP LT+ VPIA  ESD E    EE  +
Sbjct: 1066 -NYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSS 1124

Query: 944  FSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRW 1002
             S+ E+SK   + L   +SS  ST D   P E   EQ E  PE   +PE CFTE CV+++
Sbjct: 1125 ESDMEESK---EKLNATSSSEGSTVDIGAPAEG--EQPEVEPEESLEPEACFTEDCVRKF 1179

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIR 1062
             C  + I +G+GK WW LR+ C+KIVEHNWFETFIVFMILLSSGALAFEDIYIEQR+ I+
Sbjct: 1180 KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239

Query: 1063 TILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSEL 1122
            T+LEYADKVFTYIFI+EMLLKWVAYGF+VYFTNAWCWLDFLIVDVS++SL AN LGYSEL
Sbjct: 1240 TMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1299

Query: 1123 GPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1182
            G IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF
Sbjct: 1300 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1359

Query: 1183 AGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLGYLSLLQVA 1241
            AGKFY+CIN TT E FD+S VNN SEC++L+ + Q  RW NVKVN+DNVGLGYLSLLQVA
Sbjct: 1360 AGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419

Query: 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
            TFKGWMDIMYAAVDSR  E QP+YE NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479

Query: 1302 KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361
            KKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VTKQ FDI+IMI
Sbjct: 1480 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI 1539

Query: 1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDF 1421
            LICLNMVTMMVETD+QSQ   +ILY IN++FI++FTGECVLK+++LR YYFT+GWNIFDF
Sbjct: 1540 LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDF 1599

Query: 1422 VVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPA 1481
            VVVILSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPA
Sbjct: 1600 VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1659

Query: 1482 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL 1541
            LFNIGLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGL
Sbjct: 1660 LFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGL 1719

Query: 1542 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601
            L PILNSGPPDCDP+ ++PG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF
Sbjct: 1720 LAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779

Query: 1602 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL 1661
            +VATEES+EPL EDDFEMFYE WEKFDPDATQFI +++LSDF D L  PL IAKPNK++L
Sbjct: 1780 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL 1839

Query: 1662 ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTT 1721
            I +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSYEPITTT
Sbjct: 1840 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTT 1899

Query: 1722 LKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778
            LKRK EEV AI IQRAYRR+LL++ +K+ S +Y+       D  P KE  L + +++
Sbjct: 1900 LKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNE 1956



 Score =  699 bits (1804), Expect = 0.0
 Identities = 352/491 (71%), Positives = 407/491 (82%), Gaps = 21/491 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEA-RLQRNKQMEIEEPERKPRSDLEAGKNLPMI 67
           LVP GP+  R FTRESLAAIEQR  EE+A R ++ ++ E +E   KP SDLEAGK+LP I
Sbjct: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65

Query: 68  YGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKV 127
           YGD PPE++ +PLEDLDPYY NKKTFIVLNKGKAI RFSATPALY+L+PF+ +R+ AIK+
Sbjct: 66  YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125

Query: 128 LIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFT 187
           L+H+LF+M IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFT
Sbjct: 126 LVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFT 185

Query: 188 FLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSV 247
           FLRDPWNWLDF+VI  AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSV
Sbjct: 186 FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 245

Query: 248 KKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWY 307
           KKLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP     N+++  N T + N++  
Sbjct: 246 KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSLD 301

Query: 308 GNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAG 367
           GN             T+N      T   F+WD YI D+ +FYFLEG NDALLCGNSSDAG
Sbjct: 302 GN-----------GTTFN-----RTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG 345

Query: 368 HCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFF 427
            CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMIFF
Sbjct: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFF 405

Query: 428 VVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKA 487
           V++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE + A A
Sbjct: 406 VLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAA 465

Query: 488 AQALEGGEADG 498
           A + E  +  G
Sbjct: 466 AASAESRDFSG 476



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 78/340 (22%), Positives = 147/340 (43%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 118  IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 169

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++  + ++       + +LG + +LRT R LR
Sbjct: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 223

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G     C+    
Sbjct: 224  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 283

Query: 1191 -------------------NTTTSER----FDISE-VNNKSE------------CESLMH 1214
                               N TT  R    F+  E + +KS             C +   
Sbjct: 284  DNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSD 343

Query: 1215 TGQV--RWLNVK---------VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK          ++D     +LSL ++ T   W ++    + +  K    
Sbjct: 344  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 399

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 400  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+   K++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF V    +  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 12/173 (6%)

Query: 116 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYT 169
           P+  V+     V++     + I I I+ N +FM M   P   +           FTGI+T
Sbjct: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803

Query: 170 FESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALK 228
            E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K
Sbjct: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

Query: 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281
                P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV
Sbjct: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 45/173 (26%), Positives = 88/173 (50%), Gaps = 12/173 (6%)

Query: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
           P+   + +   I++    ++ I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 167

Query: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
            E ++K++A    ++ + + +  WN  D  ++T + V     ++  +S LR+FR+LR  K
Sbjct: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-EFVDLGNVSALRTFRVLRALK 226

Query: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
                P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 19/73 (26%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI-FFVVIIFLGSFYLINLILAVVAMAY 450
           F  +FL +FR++  ++ E ++   +  AG+T  +  F++++ +G+  ++NL LA++  ++
Sbjct: 928 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986

Query: 451 AEQNEATLAEDKE 463
           +  N A   +D E
Sbjct: 987 SSDNLAATDDDNE 999



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLF---------QLTLRAAGKTYM-IFFVVIIFLGSFY 437
            ++D     +L+L ++ T   W ++          +L  +     YM ++FV+ I  GSF+
Sbjct: 1404 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFF 1463

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1464 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 430 EQNQATLEE 438


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 1846 bits (4781), Expect = 0.0
 Identities = 920/1253 (73%), Positives = 1058/1253 (84%), Gaps = 10/1253 (0%)

Query: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
            +++ +EELEE+ QKCPP WYK ++  LIW+C   WLK K++++L+VMDPFVDL ITICIV
Sbjct: 709  LTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIV 768

Query: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            LNTLFMAMEHYPMT+HF+NVLTVGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 769  LNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 828

Query: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
            VTLSLVELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 829  VTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 888

Query: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769
            IVFIFAVVGMQLFGKSYK+CVCKIA DC LPRWHM+DFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 889  IVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDC 948

Query: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829
            MEVAGQAMCLTVF+MVMVIGNLVVLNLFLALLLSSFSAD+LAA+D+D EMNNLQIA+ R+
Sbjct: 949  MEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRM 1008

Query: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889
              G+ + K  +   +    +  + I+  +   D      ++  +    E  +  +  LK 
Sbjct: 1009 HKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDY-LKD 1067

Query: 890  DNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEP 947
             N   + +G        +  E D+++FINNP LT+ VPIA  ESD E    E+  + S+ 
Sbjct: 1068 VNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDL 1127

Query: 948  EDSKKPPQPLYDGNSSVCSTADYKPP-EEDPEEQAEENPEGEQPEECFTEACVQRWPCLY 1006
            E+SK+        +SS  ST D   P EE P  + EE  E   PE CFTE CVQR+ C  
Sbjct: 1128 EESKEKLNE--SSSSSEGSTVDIGAPVEEQPVVEPEETLE---PEACFTEGCVQRFKCCQ 1182

Query: 1007 VDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILE 1066
            +++ +GRGK+WW LRR CF+IVEHNWFETFIVFMILLSSGALAFEDIYI+QR+ I+T+LE
Sbjct: 1183 INVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLE 1242

Query: 1067 YADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIK 1126
            YADKVFTYIFI+EMLLKWVAYG++ YFTNAWCWLDFLIVDVS++SL AN LGYSELG IK
Sbjct: 1243 YADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIK 1302

Query: 1127 SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1186
            SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF
Sbjct: 1303 SLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1362

Query: 1187 YYCINTTTSERFDISEVNNKSECESLMHTGQV-RWLNVKVNYDNVGLGYLSLLQVATFKG 1245
            Y+CINTTT +RFDI +VNN ++C  L+   +  RW NVKVN+DNVG GYLSLLQVATFKG
Sbjct: 1363 YHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKG 1422

Query: 1246 WMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1305
            WMDIMYAAVDSR  E QP+YE +LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1423 WMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1482

Query: 1306 GGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICL 1365
            GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VT+Q FDI+IMILICL
Sbjct: 1483 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICL 1542

Query: 1366 NMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVI 1425
            NMVTMMVETD+QS+    IL  IN++FI++FTGECVLK+++LR YYFT+GWNIFDFVVVI
Sbjct: 1543 NMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVI 1602

Query: 1426 LSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNI 1485
            LSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1603 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1662

Query: 1486 GLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPI 1545
            GLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGLL PI
Sbjct: 1663 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1722

Query: 1546 LNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVAT 1605
            LNS PPDCDPN  NPG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF+VAT
Sbjct: 1723 LNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1782

Query: 1606 EESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLD 1665
            EES+EPL EDDFEMFYE WEKFDPDATQF+ + +LS F   L+ PL + +PNK++LI +D
Sbjct: 1783 EESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMD 1842

Query: 1666 LPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRK 1725
            LPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSY+PITTTLKRK
Sbjct: 1843 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRK 1902

Query: 1726 HEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778
             EEV A+ IQRAYRRHLL+R++KQAS+ Y  +    G +   KE ++ + +++
Sbjct: 1903 QEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINE 1955



 Score =  674 bits (1738), Expect = 0.0
 Identities = 343/487 (70%), Positives = 393/487 (80%), Gaps = 27/487 (5%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68
           LVP GP+    FTRESLAAIE+R  EE+A+  +  + + +E   KP SDLEAGKNLP IY
Sbjct: 6   LVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIY 65

Query: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128
           GD PPE++  PLEDLDPYY NKKTFIVLNKGKAIFRFSAT ALY+L+PF+ +R+ AIK+L
Sbjct: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKIL 125

Query: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188
           +H+LFSM IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKI+ARGFC++DFTF
Sbjct: 126 VHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTF 185

Query: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248
           LRDPWNWLDF+VI  AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 186 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245

Query: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYG 308
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP    TN +   +           
Sbjct: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP----TNASLEEH----------- 290

Query: 309 NEMWYGNDSWYANDTWNSHASWATNDT---FDWDAYISDEGNFYFLEGSNDALLCGNSSD 365
                   S   N T N + +   N+T   FDW +YI D    YFLEG  DALLCGNSSD
Sbjct: 291 --------SIEKNITVNYNGT-LINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSD 341

Query: 366 AGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI 425
           AG CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMI
Sbjct: 342 AGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI 401

Query: 426 FFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKA 485
           FFV++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQM+E+ KK QE  ++A
Sbjct: 402 FFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQA 461

Query: 486 KAAQALE 492
             A A E
Sbjct: 462 ATATASE 468



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 79/340 (23%), Positives = 141/340 (41%), Gaps = 81/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            LR+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 117  LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 168

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++  + ++       + +LG + +LRT R LR
Sbjct: 169  SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 222

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP 282

Query: 1188 --------------------YCINTTTSERFDISEVNNKSE-------------CESLMH 1214
                                  IN T  E FD       S              C +   
Sbjct: 283  TNASLEEHSIEKNITVNYNGTLINETVFE-FDWKSYIQDSRYHYFLEGFLDALLCGNSSD 341

Query: 1215 TGQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 342  AGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 397

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 398  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 431



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 75/378 (19%), Positives = 155/378 (41%), Gaps = 55/378 (14%)

Query: 494  GEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELE-----EAHQKCPPWW 548
            GE+D +  + +D +   D  + ++     SSS +    D    +E     E  +   P  
Sbjct: 1109 GESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEA 1168

Query: 549  YKCAHKVLIWNCC---------APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAME- 598
                  V  + CC           W   +     IV   + +  I   I+L++  +A E 
Sbjct: 1169 CFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFED 1228

Query: 599  -HYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVE- 656
             +    +    +L   + VFT IF  EM+LK +A     YF   W   D +IV +SLV  
Sbjct: 1229 IYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSL 1288

Query: 657  ----LGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVF 712
                LG + +  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   
Sbjct: 1289 TANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1348

Query: 713  IFAVVGMQLFGKSYKECV------------------CKIALDCN-LPRW-----HMHDFF 748
            IF+++G+ LF   +  C+                  C   ++ N   RW     +  +  
Sbjct: 1349 IFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVG 1408

Query: 749  HSFLIVFRILCGE-WIETMWDCMEVAG--------QAMCLTVFLMVMVI-GNLVVLNLFL 798
              +L + ++   + W++ M+  ++           +++ + ++ ++ +I G+   LNLF+
Sbjct: 1409 FGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFI 1468

Query: 799  ALLLSSFSADSLAASDED 816
             +++ +F+        +D
Sbjct: 1469 GVIIDNFNQQKKKFGGQD 1486



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 86/169 (50%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-----PPPWSKNVEYT---FTGIYTFE 171
            +RR   +++ H  F  FI+  IL +   +   D            +EY    FT I+  E
Sbjct: 1196 LRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILE 1255

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A G+     T+  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 1256 MLLKWVAYGYQ----TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1311

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1312 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 47/173 (27%), Positives = 87/173 (50%), Gaps = 12/173 (6%)

Query: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
           P+   + I   I++     + I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 113 PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 166

Query: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFK 678
            E ++K+IA    ++ + + +  WN  D  ++T + V     ++  +S LR+FR+LR  K
Sbjct: 167 FESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT-EFVDLGNVSALRTFRVLRALK 225

Query: 679 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
                P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 226 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCI 278



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 51/187 (27%), Positives = 95/187 (50%), Gaps = 13/187 (6%)

Query: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPPPWS--KN 159
           ++FS    ++  SP+ +  +  + +++   F  + I I I+ N +FM M   P      N
Sbjct: 728 YKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNN 787

Query: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGN 214
           V       FTGI+T E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  
Sbjct: 788 VLTVGNLVFTGIFTAEMFLKIIA----MDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 843

Query: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
           +S LR+FR+LR  K     P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G
Sbjct: 844 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 902

Query: 275 NLRQKCV 281
              + CV
Sbjct: 903 KSYKDCV 909



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 29/155 (18%), Positives = 65/155 (41%), Gaps = 18/155 (11%)

Query: 392  FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
            F  +FL +FR++  ++ E ++     A     +  F++++ +G+  ++NL LA++  +++
Sbjct: 926  FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 985

Query: 452  EQNEATLAEDKE------------------KEEEFQQMLEKFKKHQEELEKAKAAQALEG 493
              N A   +D E                  K + ++ + + F + Q+ L++ K    L  
Sbjct: 986  ADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNN 1045

Query: 494  GEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDS 528
             +      H  +    LD  +   G      +G S
Sbjct: 1046 KKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSS 1080


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 1817 bits (4707), Expect = 0.0
 Identities = 925/1290 (71%), Positives = 1063/1290 (82%), Gaps = 20/1290 (1%)

Query: 509  SLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFK 568
            S++  +   G  R  S   S +++ MEELEE+ QKCPP WY+ A+  LIW+CC  WLK K
Sbjct: 643  SMEMLEDSSGRQRAVSIA-SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVK 701

Query: 569  NIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628
            ++++LIVMDPFVDL ITICIVLNTLFMAMEHYPMTE F +VLTVGNLVFTGIFTAEMVLK
Sbjct: 702  HLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLK 761

Query: 629  LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
            +IAMDPY YFQ+GWNIFD IIV+LSL+ELGL+NV+GLSVLRSFRLLRVFKLAKSWPTLNM
Sbjct: 762  IIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNM 821

Query: 689  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
            LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFF
Sbjct: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 881

Query: 749  HSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSAD 808
            HSFLIVFR+LCGEWIETMWDCMEVAGQ MCL VF++VMVIGNLVVLNLFLALLLSSFS+D
Sbjct: 882  HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 941

Query: 809  SLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKIL-SPKDIMLSLGEADGAGEA 867
            +LAA+D+D EMNNLQIA+GR++ GI + K  +           PK I +  G    +  +
Sbjct: 942  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS 1001

Query: 868  GEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP 925
               G    ++         L+  N   + +G        +  E D+++FINNP LT+ VP
Sbjct: 1002 NNTGIEISKELNY------LRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP 1055

Query: 926  IASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP 985
            IA  ESD E    EE  + SE E+SK   + L   +SS  ST D   P E   EQAE  P
Sbjct: 1056 IAVGESDFENLNTEEFSSESELEESK---EKLNATSSSEGSTVDVVLPREG--EQAETEP 1110

Query: 986  EGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044
            E + +PE CFTE C++++P   V   +G+GK WW LR+ C+ IVEHNWFETFIVFMILLS
Sbjct: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170

Query: 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLI 1104
            SGALAFEDIYIEQR+ I+T+LEYADKVFTYIFI+EMLLKWVAYGF+ YFTNAWCWLDFLI
Sbjct: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230

Query: 1105 VDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1164
            VDVS++SLVAN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVL
Sbjct: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290

Query: 1165 LVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVK 1224
            LVCLIFWLIFSIMGVNLFAGKFY+C+N TT   FDIS+VNN S+C++L    Q RW NVK
Sbjct: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQARWKNVK 1348

Query: 1225 VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSF 1284
            VN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR+ + QP YE NLYMYLYFVIFIIFGSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408

Query: 1285 FTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG 1344
            FTLNLFIGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQG 1468

Query: 1345 MVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404
            MV+D VT+Q FDI+IMILICLNMVTMMVETD+Q +    +L  IN++FI++FTGE VLK+
Sbjct: 1469 MVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1528

Query: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
            ++LR YYFT+GWNIFDFVVVILSIVG+ L+++I+KYFVSPTLFRVIRLARIGR+LRLI+G
Sbjct: 1529 VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKG 1588

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGN 1524
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE+GIDDMFNFETFGN
Sbjct: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648

Query: 1525 SIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIII 1584
            S+ICLF+ITTSAGWDGLL PILNS PPDCDP+  +PG+SVKGDCGNPS+GI FF SYIII
Sbjct: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708

Query: 1585 SFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFV 1644
            SFL+VVNMYIA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF 
Sbjct: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768

Query: 1645 DTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704
              L  PL IAKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  ME++
Sbjct: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828

Query: 1705 FMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD 1764
            FMA+NPSKVSYEPITTTLKRK EEV A  IQR +R +LL++ +K  S  Y         D
Sbjct: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1888

Query: 1765 APEKEGLLANTMSKMYGHE--NGNSSSPSP 1792
             P K+ ++ + ++     E  +G+SS+ SP
Sbjct: 1889 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSP 1918



 Score =  696 bits (1796), Expect = 0.0
 Identities = 347/484 (71%), Positives = 395/484 (81%), Gaps = 24/484 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68
           LVP GPE  R FTRESLAAIE+RA EE+A+  + +Q   +E + KP SDLEAGKNLP IY
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65

Query: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128
           GD PPE++  PLEDLDPYY NKKTFIV+NKGKAIFRFSAT ALY+L+P + VR+ AIK+L
Sbjct: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKIL 125

Query: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188
           +H+LFSM IM TILTNCVFMT+S+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFTF
Sbjct: 126 VHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

Query: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248
           LRDPWNWLDFSVI+MAY+TEFV LGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 186 LRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245

Query: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN--DTNTTWYSNDTWYGNDTW 306
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP  +  +TNTT Y N T   N T+
Sbjct: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTF 305

Query: 307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDA 366
                                    T  TF+W  YI D+ +FY L+G  D LLCGN SDA
Sbjct: 306 VN----------------------VTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 367 GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF 426
           G CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQDYWENL+QLTLRAAGKTYMIF
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486
           FV++IFLGSFYL+NLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE +   
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463

Query: 487 AAQA 490
           AA A
Sbjct: 464 AASA 467



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 76/340 (22%), Positives = 143/340 (42%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNV-----EYT---FTGIYTFE 168

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++ ++ ++       +  LG + +LRT R LR
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVSLGNVSALRTFRVLR 222

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 282

Query: 1188 --YCINTTTSERFDISEVNNKSECESLMHT------------------------------ 1215
                  T T+  F+ +  +N +     M T                              
Sbjct: 283  SDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSD 342

Query: 1216 -GQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 343  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK---- 398

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 399  -----TYM-IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG I +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 21/186 (11%)

Query: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESLIKILARG 180
           +++     + I I I+ N +FM M   P   +           FTGI+T E ++KI+A  
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764

Query: 181 FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNI---SALRTFRVLRALKTITVIPGLK 237
             +D + + ++ WN  D  ++ ++ +   + L N+   S LR+FR+LR  K     P L 
Sbjct: 765 --MDPYYYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFND--TNTTWY 295
            ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV      ND  T   W+
Sbjct: 821 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV---CKINDDCTLPRWH 876

Query: 296 SNDTWY 301
            ND ++
Sbjct: 877 MNDFFH 882



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 45/164 (27%), Positives = 84/164 (51%), Gaps = 16/164 (9%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA-- 631
           I++     + I   I+ N +FM + + P  +   NV       FTGI+T E ++K++A  
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPP--DWTKNV----EYTFTGIYTFESLIKILARG 177

Query: 632 --MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRVFKLAKSWPTLN 687
             ++ + + +  WN  D  ++ ++ V   + L NV   S LR+FR+LR  K     P L 
Sbjct: 178 FCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNV---SALRTFRVLRALKTISVIPGLK 234

Query: 688 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
            ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 235 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 278



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 28/119 (23%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINLILAVVAMAY 450
           F  +FL +FR++  ++ E ++   +  AG+T  +I F++++ +G+  ++NL LA++  ++
Sbjct: 880 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938

Query: 451 AEQNEATLAEDKEKEE------EFQQMLEKFKKHQEE------LEKAKAAQALEGGEAD 497
           +  N A   +D E           Q+ ++  K    E        K K  +  EG + D
Sbjct: 939 SSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKID 997



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)

Query: 361  GNSSDAGHCPEGYECIKTGRNPNYGYT--SYDTFSWAFLALFRLMTQDYWENLFQLTLRA 418
            GN  D        +C   G+   +     ++D     +LAL ++ T   W ++    + +
Sbjct: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 419  AG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEF 468
                         YM ++FV+ I  GSF+ +NL + V+   + +Q +    +D    EE 
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 469  QQMLEKFKK 477
            ++     KK
Sbjct: 1441 KKYYNAMKK 1449



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE 428

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 429 EQNQATLEE 437


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 1817 bits (4707), Expect = 0.0
 Identities = 925/1290 (71%), Positives = 1063/1290 (82%), Gaps = 20/1290 (1%)

Query: 509  SLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFK 568
            S++  +   G  R  S   S +++ MEELEE+ QKCPP WY+ A+  LIW+CC  WLK K
Sbjct: 643  SMEMLEDSSGRQRAVSIA-SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVK 701

Query: 569  NIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628
            ++++LIVMDPFVDL ITICIVLNTLFMAMEHYPMTE F +VLTVGNLVFTGIFTAEMVLK
Sbjct: 702  HLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLK 761

Query: 629  LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
            +IAMDPY YFQ+GWNIFD IIV+LSL+ELGL+NV+GLSVLRSFRLLRVFKLAKSWPTLNM
Sbjct: 762  IIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNM 821

Query: 689  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
            LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFF
Sbjct: 822  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 881

Query: 749  HSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSAD 808
            HSFLIVFR+LCGEWIETMWDCMEVAGQ MCL VF++VMVIGNLVVLNLFLALLLSSFS+D
Sbjct: 882  HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 941

Query: 809  SLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKIL-SPKDIMLSLGEADGAGEA 867
            +LAA+D+D EMNNLQIA+GR++ GI + K  +           PK I +  G    +  +
Sbjct: 942  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS 1001

Query: 868  GEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP 925
               G    ++         L+  N   + +G        +  E D+++FINNP LT+ VP
Sbjct: 1002 NNTGIEISKELNY------LRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP 1055

Query: 926  IASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP 985
            IA  ESD E    EE  + SE E+SK   + L   +SS  ST D   P E   EQAE  P
Sbjct: 1056 IAVGESDFENLNTEEFSSESELEESK---EKLNATSSSEGSTVDVVLPREG--EQAETEP 1110

Query: 986  EGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044
            E + +PE CFTE C++++P   V   +G+GK WW LR+ C+ IVEHNWFETFIVFMILLS
Sbjct: 1111 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1170

Query: 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLI 1104
            SGALAFEDIYIEQR+ I+T+LEYADKVFTYIFI+EMLLKWVAYGF+ YFTNAWCWLDFLI
Sbjct: 1171 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1230

Query: 1105 VDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1164
            VDVS++SLVAN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVL
Sbjct: 1231 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1290

Query: 1165 LVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVK 1224
            LVCLIFWLIFSIMGVNLFAGKFY+C+N TT   FDIS+VNN S+C++L    Q RW NVK
Sbjct: 1291 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQARWKNVK 1348

Query: 1225 VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSF 1284
            VN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR+ + QP YE NLYMYLYFVIFIIFGSF
Sbjct: 1349 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1408

Query: 1285 FTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG 1344
            FTLNLFIGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG
Sbjct: 1409 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQG 1468

Query: 1345 MVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404
            MV+D VT+Q FDI+IMILICLNMVTMMVETD+Q +    +L  IN++FI++FTGE VLK+
Sbjct: 1469 MVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1528

Query: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
            ++LR YYFT+GWNIFDFVVVILSIVG+ L+++I+KYFVSPTLFRVIRLARIGR+LRLI+G
Sbjct: 1529 VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKG 1588

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGN 1524
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE+GIDDMFNFETFGN
Sbjct: 1589 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1648

Query: 1525 SIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIII 1584
            S+ICLF+ITTSAGWDGLL PILNS PPDCDP+  +PG+SVKGDCGNPS+GI FF SYIII
Sbjct: 1649 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1708

Query: 1585 SFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFV 1644
            SFL+VVNMYIA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF 
Sbjct: 1709 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1768

Query: 1645 DTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704
              L  PL IAKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  ME++
Sbjct: 1769 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1828

Query: 1705 FMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD 1764
            FMA+NPSKVSYEPITTTLKRK EEV A  IQR +R +LL++ +K  S  Y         D
Sbjct: 1829 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1888

Query: 1765 APEKEGLLANTMSKMYGHE--NGNSSSPSP 1792
             P K+ ++ + ++     E  +G+SS+ SP
Sbjct: 1889 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSP 1918



 Score =  698 bits (1802), Expect = 0.0
 Identities = 348/484 (71%), Positives = 396/484 (81%), Gaps = 24/484 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68
           LVP GPE  R FTRESLAAIE+RA EE+A+  + +Q   +E + KP SDLEAGKNLP IY
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65

Query: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128
           GD PPE++  PLEDLDPYY NKKTFIV+NKGKAIFRFSAT ALY+L+P + VR+ AIK+L
Sbjct: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKIL 125

Query: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188
           +H+LFSM IM TILTNCVFMT+S+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFTF
Sbjct: 126 VHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

Query: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248
           LRDPWNWLDFSVI+MAY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245

Query: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN--DTNTTWYSNDTWYGNDTW 306
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP  +  +TNTT Y N T   N T+
Sbjct: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTF 305

Query: 307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDA 366
                                    T  TF+W  YI D+ +FY L+G  D LLCGN SDA
Sbjct: 306 VN----------------------VTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 367 GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF 426
           G CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQDYWENL+QLTLRAAGKTYMIF
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486
           FV++IFLGSFYL+NLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE +   
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463

Query: 487 AAQA 490
           AA A
Sbjct: 464 AASA 467



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 76/340 (22%), Positives = 144/340 (42%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNV-----EYT---FTGIYTFE 168

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++ ++ ++       + +LG + +LRT R LR
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSALRTFRVLR 222

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 282

Query: 1188 --YCINTTTSERFDISEVNNKSECESLMHT------------------------------ 1215
                  T T+  F+ +  +N +     M T                              
Sbjct: 283  SDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSD 342

Query: 1216 -GQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 343  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK---- 398

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 399  -----TYM-IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG I +LRT R LR
Sbjct: 1206 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1261

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1262 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1310



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 21/186 (11%)

Query: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESLIKILARG 180
           +++     + I I I+ N +FM M   P   +           FTGI+T E ++KI+A  
Sbjct: 707 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 764

Query: 181 FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNI---SALRTFRVLRALKTITVIPGLK 237
             +D + + ++ WN  D  ++ ++ +   + L N+   S LR+FR+LR  K     P L 
Sbjct: 765 --MDPYYYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 820

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFND--TNTTWY 295
            ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV      ND  T   W+
Sbjct: 821 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV---CKINDDCTLPRWH 876

Query: 296 SNDTWY 301
            ND ++
Sbjct: 877 MNDFFH 882



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 42/162 (25%), Positives = 83/162 (51%), Gaps = 12/162 (7%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA-- 631
           I++     + I   I+ N +FM + + P  +   NV       FTGI+T E ++K++A  
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPP--DWTKNV----EYTFTGIYTFESLIKILARG 177

Query: 632 --MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 689
             ++ + + +  WN  D  ++ ++ V     ++  +S LR+FR+LR  K     P L  +
Sbjct: 178 FCLEDFTFLRDPWNWLDFSVIVMAYVT-EFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236

Query: 690 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           +  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 278



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 28/119 (23%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINLILAVVAMAY 450
           F  +FL +FR++  ++ E ++   +  AG+T  +I F++++ +G+  ++NL LA++  ++
Sbjct: 880 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 938

Query: 451 AEQNEATLAEDKEKEE------EFQQMLEKFKKHQEE------LEKAKAAQALEGGEAD 497
           +  N A   +D E           Q+ ++  K    E        K K  +  EG + D
Sbjct: 939 SSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKID 997



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)

Query: 361  GNSSDAGHCPEGYECIKTGRNPNYGYT--SYDTFSWAFLALFRLMTQDYWENLFQLTLRA 418
            GN  D        +C   G+   +     ++D     +LAL ++ T   W ++    + +
Sbjct: 1321 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1380

Query: 419  AG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEF 468
                         YM ++FV+ I  GSF+ +NL + V+   + +Q +    +D    EE 
Sbjct: 1381 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1440

Query: 469  QQMLEKFKK 477
            ++     KK
Sbjct: 1441 KKYYNAMKK 1449



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE 428

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 429 EQNQATLEE 437


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 1817 bits (4707), Expect = 0.0
 Identities = 925/1290 (71%), Positives = 1063/1290 (82%), Gaps = 20/1290 (1%)

Query: 509  SLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFK 568
            S++  +   G  R  S   S +++ MEELEE+ QKCPP WY+ A+  LIW+CC  WLK K
Sbjct: 692  SMEMLEDSSGRQRAVSIA-SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVK 750

Query: 569  NIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLK 628
            ++++LIVMDPFVDL ITICIVLNTLFMAMEHYPMTE F +VLTVGNLVFTGIFTAEMVLK
Sbjct: 751  HLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLK 810

Query: 629  LIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
            +IAMDPY YFQ+GWNIFD IIV+LSL+ELGL+NV+GLSVLRSFRLLRVFKLAKSWPTLNM
Sbjct: 811  IIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNM 870

Query: 689  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFF 748
            LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFF
Sbjct: 871  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFF 930

Query: 749  HSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSAD 808
            HSFLIVFR+LCGEWIETMWDCMEVAGQ MCL VF++VMVIGNLVVLNLFLALLLSSFS+D
Sbjct: 931  HSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 990

Query: 809  SLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKIL-SPKDIMLSLGEADGAGEA 867
            +LAA+D+D EMNNLQIA+GR++ GI + K  +           PK I +  G    +  +
Sbjct: 991  NLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMS 1050

Query: 868  GEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP 925
               G    ++         L+  N   + +G        +  E D+++FINNP LT+ VP
Sbjct: 1051 NNTGIEISKELNY------LRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP 1104

Query: 926  IASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENP 985
            IA  ESD E    EE  + SE E+SK   + L   +SS  ST D   P E   EQAE  P
Sbjct: 1105 IAVGESDFENLNTEEFSSESELEESK---EKLNATSSSEGSTVDVVLPREG--EQAETEP 1159

Query: 986  EGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLS 1044
            E + +PE CFTE C++++P   V   +G+GK WW LR+ C+ IVEHNWFETFIVFMILLS
Sbjct: 1160 EEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLS 1219

Query: 1045 SGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLI 1104
            SGALAFEDIYIEQR+ I+T+LEYADKVFTYIFI+EMLLKWVAYGF+ YFTNAWCWLDFLI
Sbjct: 1220 SGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1279

Query: 1105 VDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVL 1164
            VDVS++SLVAN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVL
Sbjct: 1280 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1339

Query: 1165 LVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVK 1224
            LVCLIFWLIFSIMGVNLFAGKFY+C+N TT   FDIS+VNN S+C++L    Q RW NVK
Sbjct: 1340 LVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQAL--GKQARWKNVK 1397

Query: 1225 VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSF 1284
            VN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR+ + QP YE NLYMYLYFVIFIIFGSF
Sbjct: 1398 VNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSF 1457

Query: 1285 FTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG 1344
            FTLNLFIGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG
Sbjct: 1458 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQG 1517

Query: 1345 MVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404
            MV+D VT+Q FDI+IMILICLNMVTMMVETD+Q +    +L  IN++FI++FTGE VLK+
Sbjct: 1518 MVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1577

Query: 1405 LALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
            ++LR YYFT+GWNIFDFVVVILSIVG+ L+++I+KYFVSPTLFRVIRLARIGR+LRLI+G
Sbjct: 1578 VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKG 1637

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGN 1524
            AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE+GIDDMFNFETFGN
Sbjct: 1638 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGN 1697

Query: 1525 SIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIII 1584
            S+ICLF+ITTSAGWDGLL PILNS PPDCDP+  +PG+SVKGDCGNPS+GI FF SYIII
Sbjct: 1698 SMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIII 1757

Query: 1585 SFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFV 1644
            SFL+VVNMYIA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF 
Sbjct: 1758 SFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFA 1817

Query: 1645 DTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704
              L  PL IAKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  ME++
Sbjct: 1818 AALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDR 1877

Query: 1705 FMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDD 1764
            FMA+NPSKVSYEPITTTLKRK EEV A  IQR +R +LL++ +K  S  Y         D
Sbjct: 1878 FMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRID 1937

Query: 1765 APEKEGLLANTMSKMYGHE--NGNSSSPSP 1792
             P K+ ++ + ++     E  +G+SS+ SP
Sbjct: 1938 LPIKQDMIIDKLNGNSTPEKTDGSSSTTSP 1967



 Score =  698 bits (1802), Expect = 0.0
 Identities = 348/484 (71%), Positives = 396/484 (81%), Gaps = 24/484 (4%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIY 68
           LVP GPE  R FTRESLAAIE+RA EE+A+  + +Q   +E + KP SDLEAGKNLP IY
Sbjct: 6   LVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIY 65

Query: 69  GDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVL 128
           GD PPE++  PLEDLDPYY NKKTFIV+NKGKAIFRFSAT ALY+L+P + VR+ AIK+L
Sbjct: 66  GDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKIL 125

Query: 129 IHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTF 188
           +H+LFSM IM TILTNCVFMT+S+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFTF
Sbjct: 126 VHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 185

Query: 189 LRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVK 248
           LRDPWNWLDFSVI+MAY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSVK
Sbjct: 186 LRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVK 245

Query: 249 KLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN--DTNTTWYSNDTWYGNDTW 306
           KLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP  +  +TNTT Y N T   N T+
Sbjct: 246 KLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTF 305

Query: 307 YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDA 366
                                    T  TF+W  YI D+ +FY L+G  D LLCGN SDA
Sbjct: 306 VN----------------------VTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDA 343

Query: 367 GHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIF 426
           G CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQDYWENL+QLTLRAAGKTYMIF
Sbjct: 344 GQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIF 403

Query: 427 FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486
           FV++IFLGSFYL+NLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE +   
Sbjct: 404 FVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVA 463

Query: 487 AAQA 490
           AA A
Sbjct: 464 AASA 467



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 76/340 (22%), Positives = 144/340 (42%), Gaps = 80/340 (23%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 117  VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNV-----EYT---FTGIYTFE 168

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    +  + W WLDF ++ ++ ++       + +LG + +LRT R LR
Sbjct: 169  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT------EFVDLGNVSALRTFRVLR 222

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY-------- 1187
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G           
Sbjct: 223  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 282

Query: 1188 --YCINTTTSERFDISEVNNKSECESLMHT------------------------------ 1215
                  T T+  F+ +  +N +     M T                              
Sbjct: 283  SDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSD 342

Query: 1216 -GQV--RWLNVKV----NY-----DNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
             GQ    ++ VK     NY     D     +LSL ++ T   W ++    + +  K    
Sbjct: 343  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK---- 398

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 399  -----TYM-IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQ 432



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 46/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 1195 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1254

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF     T+  + W WLDF ++      ++A    + +LG I +LRT R LR
Sbjct: 1255 MLLKWVAYGFQ----TYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALR 1310

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1311 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1359



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 52/186 (27%), Positives = 93/186 (50%), Gaps = 21/186 (11%)

Query: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESLIKILARG 180
           +++     + I I I+ N +FM M   P   +           FTGI+T E ++KI+A  
Sbjct: 756 IVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIA-- 813

Query: 181 FCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNI---SALRTFRVLRALKTITVIPGLK 237
             +D + + ++ WN  D  ++ ++ +   + L N+   S LR+FR+LR  K     P L 
Sbjct: 814 --MDPYYYFQEGWNIFDGIIVSLSLME--LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLN 869

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFND--TNTTWY 295
            ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV      ND  T   W+
Sbjct: 870 MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV---CKINDDCTLPRWH 925

Query: 296 SNDTWY 301
            ND ++
Sbjct: 926 MNDFFH 931



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 42/162 (25%), Positives = 83/162 (51%), Gaps = 12/162 (7%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA-- 631
           I++     + I   I+ N +FM + + P  +   NV       FTGI+T E ++K++A  
Sbjct: 124 ILVHSLFSMLIMCTILTNCVFMTLSNPP--DWTKNV----EYTFTGIYTFESLIKILARG 177

Query: 632 --MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 689
             ++ + + +  WN  D  ++ ++ V     ++  +S LR+FR+LR  K     P L  +
Sbjct: 178 FCLEDFTFLRDPWNWLDFSVIVMAYVT-EFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236

Query: 690 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           +  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 278



 Score = 40.4 bits (93), Expect = 0.016
 Identities = 28/119 (23%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 392  FSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINLILAVVAMAY 450
            F  +FL +FR++  ++ E ++   +  AG+T  +I F++++ +G+  ++NL LA++  ++
Sbjct: 929  FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSF 987

Query: 451  AEQNEATLAEDKEKEE------EFQQMLEKFKKHQEE------LEKAKAAQALEGGEAD 497
            +  N A   +D E           Q+ ++  K    E        K K  +  EG + D
Sbjct: 988  SSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKID 1046



 Score = 36.2 bits (82), Expect = 0.30
 Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)

Query: 361  GNSSDAGHCPEGYECIKTGRNPNYGYT--SYDTFSWAFLALFRLMTQDYWENLFQLTLRA 418
            GN  D        +C   G+   +     ++D     +LAL ++ T   W ++    + +
Sbjct: 1370 GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS 1429

Query: 419  AG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEF 468
                         YM ++FV+ I  GSF+ +NL + V+   + +Q +    +D    EE 
Sbjct: 1430 RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1489

Query: 469  QQMLEKFKK 477
            ++     KK
Sbjct: 1490 KKYYNAMKK 1498



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 369 FSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYE 428

Query: 807 ADSLAASDE 815
             + A  +E
Sbjct: 429 EQNQATLEE 437


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 1811 bits (4691), Expect = 0.0
 Identities = 915/1275 (71%), Positives = 1050/1275 (82%), Gaps = 26/1275 (2%)

Query: 521  RQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFV 580
            +++ S  S +++ +EELEE+ QKCPPWWY+ AHK LIWNC   W+KFK  I+ IVMDPFV
Sbjct: 676  QRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFV 735

Query: 581  DLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQ 640
            DL ITICIVLNTLFMAMEH+PMTE F NVL +GNLVFTGIF AEMVLKLIAMDPYEYFQ 
Sbjct: 736  DLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQV 795

Query: 641  GWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 700
            GWNIFDS+IVTLSLVEL LA+V+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL
Sbjct: 796  GWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 855

Query: 701  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCG 760
            GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI  DC LPRWHM+DFFHSFLIVFR+LCG
Sbjct: 856  GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCG 915

Query: 761  EWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMN 820
            EWIETMWDCMEVAGQAMCL V++MVMVIGNLVVLNLFLALLLSSFS+D+L A +ED + N
Sbjct: 916  EWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDAN 975

Query: 821  NLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKK 880
            NLQIA+ RIK GI + K  L   +         I   + +A+          T  E+   
Sbjct: 976  NLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLN-------TKKENYIS 1028

Query: 881  EPPEEDLKKDNHILNHMGLADGPPSSLEL------DHLNFINNPYLTIQVPIASEESDLE 934
                 ++ K ++ L       G  SS++       D  +FI+NP LT+ VPIA  ESDLE
Sbjct: 1029 NHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE 1088

Query: 935  MPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECF 994
                EE  + S+ E SK     L   +SS CST D   P E  E +AE     ++PE CF
Sbjct: 1089 NMNAEELSSDSDSEYSKVR---LNRSSSSECSTVDNPLPGEGEEAEAEPM-NSDEPEACF 1144

Query: 995  TEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIY 1054
            T+ CV+R+ C  V+I  G+GK WW +R+ C+KIVEH+WFE+FIV MILLSSGALAFEDIY
Sbjct: 1145 TDGCVRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY 1204

Query: 1055 IEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVA 1114
            IE+++ I+ ILEYADK+FTYIFI+EMLLKW+AYG+K YFTNAWCWLDFLIVDVS+++LVA
Sbjct: 1205 IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVA 1264

Query: 1115 NWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174
            N LGYS+LGPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIF
Sbjct: 1265 NTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIF 1324

Query: 1175 SIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLG 1233
            SIMGVNLFAGKFY CINTT   RF  S+V N+SEC +LM+  Q VRW N+KVN+DNVGLG
Sbjct: 1325 SIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLG 1384

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            YLSLLQVATFKGW  IMYAAVDS   ++QP+YE +LYMY+YFV+FIIFGSFFTLNLFIGV
Sbjct: 1385 YLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGV 1444

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQ 1353
            IIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKIQG ++DLVT Q
Sbjct: 1445 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQ 1504

Query: 1354 AFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFT 1413
            AFDI+IM+LICLNMVTMMVE + QSQ   ++LY IN++FII+FTGECVLK+++LR YYFT
Sbjct: 1505 AFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFT 1564

Query: 1414 VGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLF 1473
            VGWNIFDFVVVI+SIVG+ L+DLI+ YFVSPTLFRVIRLARIGR+LRL++GAKGIRTLLF
Sbjct: 1565 VGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLF 1624

Query: 1474 ALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEIT 1533
            ALMMSLPALFNIGLLLFLVMFIY+IFGMSNFAYVKKE GI+DMFNFETFGNS+ICLF+IT
Sbjct: 1625 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQIT 1684

Query: 1534 TSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMY 1593
            TSAGWDGLL PILNS PPDCDP   +PG+SV+GDCGNPS+GI +F SYIIISFL+VVNMY
Sbjct: 1685 TSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1744

Query: 1594 IAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRI 1653
            IA+ILENF+VATEES+EPL EDDFEMFYE WEKFDPDATQFI +S+LSDF   L  PL I
Sbjct: 1745 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLI 1804

Query: 1654 AKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKV 1713
            AKPNK++LI +DLPMV GD+IHCLDILFA TK VLG+SGEMD+L+  MEE+FM+ANPSKV
Sbjct: 1805 AKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKV 1864

Query: 1714 SYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLA 1773
            SYEPITTTLKRK E+V A  IQRAYRR+ L++++K  S +Y    DG  DD       L 
Sbjct: 1865 SYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIY--IKDGDRDDD------LL 1916

Query: 1774 NTMSKMYGHENGNSS 1788
            N     + + N NSS
Sbjct: 1917 NKKDMAFDNVNENSS 1931



 Score =  630 bits (1624), Expect = e-180
 Identities = 322/485 (66%), Positives = 376/485 (77%), Gaps = 40/485 (8%)

Query: 6   LCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLP 65
           +  L P GP+    FT++SLA IEQR  E +++  + ++ + +E   KP SDLEAGK LP
Sbjct: 1   MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP 60

Query: 66  MIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAI 125
            IYGD PP ++  PLEDLDPYY++KKTFIVLNKGK IFRF+ATPALY+LSPFS +RR +I
Sbjct: 61  FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120

Query: 126 KVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDD 185
           K+L+H+LFSM IM TILTNC+FMTM++PP W+KNVEYTFTGIYTFESL+KILARGFCV +
Sbjct: 121 KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180

Query: 186 FTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQ 245
           FTFLRDPWNWLDF VI+ AYLTEFV+LGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQ
Sbjct: 181 FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240

Query: 246 SVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDT 305
           SVKKLSDVMILTVFCLSVFAL+GLQLFMGNL+ KC R                       
Sbjct: 241 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFR----------------------- 277

Query: 306 WYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSD 365
                     +S   N+T  S  +   ++  D+  Y      FY+LEGS DALLCG S+D
Sbjct: 278 ----------NSLENNETLESIMNTLESEE-DFRKY------FYYLEGSKDALLCGFSTD 320

Query: 366 AGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI 425
           +G CPEGY C+K GRNP+YGYTS+DTFSWAFLALFRLMTQDYWENL+Q TLRAAGKTYMI
Sbjct: 321 SGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMI 380

Query: 426 FFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKA 485
           FFVV+IFLGSFYLINLILAVVAMAY EQN+A + E K+KE EFQQML++ KK QEE E  
Sbjct: 381 FFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAI 440

Query: 486 KAAQA 490
            AA A
Sbjct: 441 AAAAA 445



 Score = 88.2 bits (217), Expect = 7e-17
 Identities = 101/442 (22%), Positives = 179/442 (40%), Gaps = 78/442 (17%)

Query: 903  PPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNS 962
            PP      H  F       I+  IA  +S  + P EE+ D   + E++ KP   L  G  
Sbjct: 6    PPGPQSFVH--FTKQSLALIEQRIAERKS--KEPKEEKKD---DDEEAPKPSSDLEAGKQ 58

Query: 963  SVCSTADYKP-----PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKW 1017
                  D  P     P ED +    +        +  T       P LY+         +
Sbjct: 59   LPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYML------SPF 112

Query: 1018 WTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFI 1077
              LRR   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+ 
Sbjct: 113  SPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNV-----EYT---FTGIYT 164

Query: 1078 MEMLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRA 1133
             E L+K +A GF V    +  + W WLDF+++  + ++   N      LG + +LRT R 
Sbjct: 165  FESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVN------LGNVSALRTFRV 218

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINT 1192
            LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C   
Sbjct: 219  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRN 278

Query: 1193 TTSERFDISEVNNKSE--------------------CESLMHTGQV--RWLNVKV----- 1225
            +      +  + N  E                    C     +GQ    +  VK+     
Sbjct: 279  SLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD 338

Query: 1226 ----NYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIF 1281
                ++D     +L+L ++ T   W ++    + +  K          YM ++FV+ I  
Sbjct: 339  YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGK---------TYM-IFFVVVIFL 388

Query: 1282 GSFFTLNLFIGVIIDNFNQQKK 1303
            GSF+ +NL + V+   + +Q +
Sbjct: 389  GSFYLINLILAVVAMAYEEQNQ 410



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 49/169 (28%), Positives = 91/169 (53%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+   K++ H+ F  FI++ IL +   +   D     K      +EY    FT I+  E
Sbjct: 1170 IRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILE 1229

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT------EFVDLGNISALRTFRVLR 225
             L+K +A G+     T+  + W WLDF ++ ++ +T       + DLG I +LRT R LR
Sbjct: 1230 MLLKWIAYGYK----TYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALR 1285

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V ALI ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1286 PLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1334



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 59/209 (28%), Positives = 106/209 (50%), Gaps = 18/209 (8%)

Query: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPPPWS--KN 159
           +RF+    ++  SP+ +  +  I  ++   F  + I I I+ N +FM M   P     KN
Sbjct: 704 YRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKN 763

Query: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFV-DLGN 214
           V       FTGI+  E ++K++A    +D + + +  WN  D  ++ ++ +  F+ D+  
Sbjct: 764 VLAIGNLVFTGIFAAEMVLKLIA----MDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG 819

Query: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
           +S LR+FR+LR  K     P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G
Sbjct: 820 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 878

Query: 275 NLRQKCVRWPPPFND--TNTTWYSNDTWY 301
              ++CV      ND  T   W+ ND ++
Sbjct: 879 KSYKECV---CKINDDCTLPRWHMNDFFH 904



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 46/181 (25%), Positives = 90/181 (49%), Gaps = 11/181 (6%)

Query: 562 APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621
           +P+   + I   I++     + I   I+ N +FM M + P  +   NV       FTGI+
Sbjct: 110 SPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPP--DWTKNV----EYTFTGIY 163

Query: 622 TAEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVF 677
           T E ++K++A    +  + + +  WN  D +++  + +     N+  +S LR+FR+LR  
Sbjct: 164 TFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT-EFVNLGNVSALRTFRVLRAL 222

Query: 678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDC 737
           K     P L  ++  +  SV  L ++ ++    + +FA++G+QLF  + K    + +L+ 
Sbjct: 223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLEN 282

Query: 738 N 738
           N
Sbjct: 283 N 283



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 54/206 (26%), Positives = 89/206 (43%), Gaps = 40/206 (19%)

Query: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
            GK IF        +NA   L    P  P+ R   KI  +V+ L     F + IM  I  N
Sbjct: 94   GKTIFR-------FNATPALYMLSPFSPLRRISIKI--LVHSL-----FSMLIMCTILTN 139

Query: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVG--------WNI 1418
             + M +          D   N+   F  I+T E ++K+LA     F VG        WN 
Sbjct: 140  CIFMTMNNPP------DWTKNVEYTFTGIYTFESLVKILARG---FCVGEFTFLRDPWNW 190

Query: 1419 FDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMS 1478
             DFVV++ + +           FV+      +R  R+ R L+ I    G++T++ AL+ S
Sbjct: 191  LDFVVIVFAYL---------TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQS 241

Query: 1479 LPALFNIGLLLFLVMFIYSIFGMSNF 1504
            +  L ++ +L    + ++++ G+  F
Sbjct: 242  VKKLSDVMILTVFCLSVFALIGLQLF 267



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 103/517 (19%), Positives = 197/517 (38%), Gaps = 123/517 (23%)

Query: 346  GNFYFLEGSNDALLCGNSSDAGHCPEGYEC---IKTGRNPNYGY--TSYDTFSWAFLALF 400
            G FY    + D    G+   A   P   EC   +   +N  +     ++D     +L+L 
Sbjct: 1334 GKFYECINTTD----GSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLL 1389

Query: 401  RLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFYLINLILAVVAMAY 450
            ++ T   W  +    + +             YM I+FVV I  GSF+ +NL + V+   +
Sbjct: 1390 QVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNF 1449

Query: 451  AEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSL 510
             +Q +    +D         M E+ KK+   ++K  + +  +     G+   G  C   L
Sbjct: 1450 NQQKKKLGGQD-------IFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQG--CIFDL 1500

Query: 511  DTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNI 570
             T+Q    +       +       +E +  H     +W      +L    C        +
Sbjct: 1501 VTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGEC--------V 1552

Query: 571  IHLIVMDPFVDLGITICIVLNTLFMAMEHYPMT---EHFDNVLTVGNLVFTGIFTAEMVL 627
            + LI                     ++ HY  T     FD V+ + ++V  G+F A+++ 
Sbjct: 1553 LKLI---------------------SLRHYYFTVGWNIFDFVVVIISIV--GMFLADLI- 1588

Query: 628  KLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLN 687
                        + + +  ++   + L  +G             R+LR+ K AK   TL 
Sbjct: 1589 ------------ETYFVSPTLFRVIRLARIG-------------RILRLVKGAKGIRTLL 1623

Query: 688  MLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDF 747
              + +   S+ AL N+ L+L +++FI+A+ GM  F    KE       D     ++   F
Sbjct: 1624 FALMM---SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKE-------DGINDMFNFETF 1673

Query: 748  FHSFLIVFRILCGEWIETMW---------DC------------MEVAGQAMCLTVFLMVM 786
             +S + +F+I      + +          DC             +    ++ +  F+  +
Sbjct: 1674 GNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYI 1733

Query: 787  VIGNLVVLNLFLALLLSSFSA----DSLAASDEDGEM 819
            +I  LVV+N+++A++L +FS      +   S++D EM
Sbjct: 1734 IISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEM 1770



 Score = 37.7 bits (86), Expect = 0.10
 Identities = 16/72 (22%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  +FL +FR++  ++ E ++     A     +I +++++ +G+  ++NL LA++  +++
Sbjct: 902 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFS 961

Query: 452 EQNEATLAEDKE 463
             N   + ED +
Sbjct: 962 SDNLTAIEEDPD 973


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 1803 bits (4669), Expect = 0.0
 Identities = 915/1235 (74%), Positives = 1026/1235 (83%), Gaps = 53/1235 (4%)

Query: 534  MEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTL 593
            +EELEE+ +KCPP WYK A+  LIW C   W+K K I++LIVMDPFVDL ITICIVLNTL
Sbjct: 709  VEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTL 768

Query: 594  FMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLS 653
            FMAMEH+PMT  F++VL VGNLVFTGIFTAEM LKLIAMDPY YFQ+GWNIFD  IV+LS
Sbjct: 769  FMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLS 828

Query: 654  LVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 713
            L+EL LA+V+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI
Sbjct: 829  LMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 888

Query: 714  FAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVA 773
            FAVVGMQLFGKSYKECVCKI  DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDCMEVA
Sbjct: 889  FAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVA 948

Query: 774  GQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGI 833
            GQAMCL VF+MVMVIGNLVVLNLFLALLLSSFSAD+LAA+D+DGEMNNLQI++ RIK G+
Sbjct: 949  GQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGV 1008

Query: 834  GFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHI 893
             + K  +   +                     +  EA E  P DE  E      KK N I
Sbjct: 1009 AWTKLKVHAFMQAHF-----------------KQREADEVKPLDELYE------KKANCI 1045

Query: 894  LNHMGL---------------ADGPPSSLEL-----DHLNFINNPYLTIQVPIASEESDL 933
             NH G                  G  SS+E      DH++FINNP LT++VPIA  ESD 
Sbjct: 1046 ANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDF 1105

Query: 934  EMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPP-EEDPEEQAEENPEGEQPEE 992
            E    E+  + S+PE SK     L D +SS  ST D KP  EE P EQ EE  +   P+ 
Sbjct: 1106 ENLNTEDVSSESDPEGSK---DKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLD---PDA 1159

Query: 993  CFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFED 1052
            CFTE CVQR+ C  V+I +G GK WW LR+ CF IVEHNWFETFI+FMILLSSGALAFED
Sbjct: 1160 CFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFED 1219

Query: 1053 IYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISL 1112
            IYIEQR+ IRTILEYADKVFTYIFI+EMLLKW AYGF  +FTNAWCWLDFLIV VS++SL
Sbjct: 1220 IYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSL 1279

Query: 1113 VANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
            +AN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWL
Sbjct: 1280 IANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWL 1339

Query: 1173 IFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLM--HTGQVRWLNVKVNYDNV 1230
            IFSIMGVNLFAGK++YC N T+  RF+I +VNNK+ECE LM  +  ++RW NVK+N+DNV
Sbjct: 1340 IFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNV 1399

Query: 1231 GLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLF 1290
            G GYL+LLQVATFKGWMDIMYAAVDSR+ +EQP+YE N+YMY+YFVIFIIFGSFFTLNLF
Sbjct: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459

Query: 1291 IGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLV 1350
            IGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKIQG+V+D V
Sbjct: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFV 1519

Query: 1351 TKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQY 1410
            T+QAFDI IM+LICLNMVTMMVETD QS+   +ILY IN++F+I FT ECVLKM ALR Y
Sbjct: 1520 TQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY 1579

Query: 1411 YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRT 1470
            YFT+GWNIFDFVVVILSIVG+ L+D+I+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRT
Sbjct: 1580 YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRT 1639

Query: 1471 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLF 1530
            LLFALMMSLPALFNIGLLLFLVMFI+SIFGMSNFAYVK E+GIDDMFNFETFGNS+ICLF
Sbjct: 1640 LLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLF 1699

Query: 1531 EITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVV 1590
            +ITTSAGWDGLL PILN  PPDC  + E+PG+  KGDCGNPS+GI FF SYIIISFLIVV
Sbjct: 1700 QITTSAGWDGLLLPILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVV 1758

Query: 1591 NMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEP 1650
            NMYIAIILENF+VATEES++PL EDDFE FYE WEKFDPDATQFI Y +L+DF D L+ P
Sbjct: 1759 NMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHP 1818

Query: 1651 LRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANP 1710
            LR+ KPN I+LI +DLPMV GD+IHCLDILFA TK VLGDSGE+D L+Q MEE+F+A+NP
Sbjct: 1819 LRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNP 1878

Query: 1711 SKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQR 1745
            SKVSYEPITTTL+RK EEV A+ +QRAYR HL +R
Sbjct: 1879 SKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARR 1913



 Score =  653 bits (1684), Expect = 0.0
 Identities = 337/552 (61%), Positives = 400/552 (72%), Gaps = 59/552 (10%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L P GP+  +PFT ESLA IE+R  E + +       + + + E+ + KP SDLEAGK+L
Sbjct: 6   LAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P IYGD P  ++ +PLED DPYY  +KTF+VLN+GK +FRFSATPALY+LSPF+++RR A
Sbjct: 66  PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIA 125

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           IK+LIH++FSM IM TILTNCVFMT S+PP WSKNVEYTFTGIYTFESL+KI+ARGFC+D
Sbjct: 126 IKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCID 185

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVIMMAY+TEFV+LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 186 GFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 245

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKLSDVMILTVFCLSVFAL+GLQLFMGNLR KCV WP  F                 
Sbjct: 246 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINF----------------- 288

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                     N+S+  N T            FDW+ YI+++ NFY + G  + LLCGNSS
Sbjct: 289 ----------NESYLENGT----------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSS 328

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY+C+K GRNPNYGYTS+DTFSWAFLALFRLMTQDYWENL+QLTLRAAGKTYM
Sbjct: 329 DAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM 388

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEK 484
           IFFV++IF+GSFYL+NLILAVVAMAY EQN+ATL E ++KE EF+ MLE+ KK QEE + 
Sbjct: 389 IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQA 448

Query: 485 AKAAQAL----------EGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAM 534
           A  A +           EG E  G P    + +     S  E+   R+            
Sbjct: 449 AAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRK--------Q 500

Query: 535 EELEEAHQKCPP 546
           +EL E  +K  P
Sbjct: 501 KELSEGEEKGDP 512



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 103/434 (23%), Positives = 180/434 (41%), Gaps = 105/434 (24%)

Query: 949  DSKKP--PQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLY 1006
            DS KP  P+ L +    +  +   KPP+ D   +  E+ E  +P+        +  P +Y
Sbjct: 12   DSFKPFTPESLANIERRIAESKLKKPPKADGSHR--EDDEDSKPKPNSDLEAGKSLPFIY 69

Query: 1007 VDISQG-----------------------RGKKWWT---------------LRRACFKIV 1028
             DI QG                       RGK  +                +RR   KI+
Sbjct: 70   GDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKIL 129

Query: 1029 EHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYG 1088
             H+ F   I+  IL +   + F +     + V     EY    FT I+  E L+K +A G
Sbjct: 130  IHSVFSMIIMCTILTNCVFMTFSNPPDWSKNV-----EYT---FTGIYTFESLVKIIARG 181

Query: 1089 FKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFE 1144
            F +    +  + W WLDF ++ ++ I+   N      LG + +LRT R LR L+ +S   
Sbjct: 182  FCIDGFTFLRDPWNWLDFSVIMMAYITEFVN------LGNVSALRTFRVLRALKTISVIP 235

Query: 1145 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-----YYCINTTTS---- 1195
            G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G        + IN   S    
Sbjct: 236  GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLEN 295

Query: 1196 --ERFDISE-VNNKSE------------CESLMHTGQV----------RWLNV-KVNYDN 1229
              + FD  E +NNK+             C +    GQ           R  N    ++D 
Sbjct: 296  GTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDT 355

Query: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289
                +L+L ++ T   W ++    + +  K          YM ++FV+ I  GSF+ +NL
Sbjct: 356  FSWAFLALFRLMTQDYWENLYQLTLRAAGK---------TYM-IFFVLVIFVGSFYLVNL 405

Query: 1290 FIGVIIDNFNQQKK 1303
             + V+   + +Q +
Sbjct: 406  ILAVVAMAYEEQNQ 419



 Score = 74.7 bits (182), Expect = 8e-13
 Identities = 50/187 (26%), Positives = 98/187 (52%), Gaps = 13/187 (6%)

Query: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPP--PWSKN 159
           ++F+ T  ++   P+ +  +  + +++   F  + I I I+ N +FM M   P  P  ++
Sbjct: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783

Query: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGN 214
           V       FTGI+T E  +K++A    +D + + ++ WN  D  ++ ++ +     D+  
Sbjct: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839

Query: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
           +S LR+FR+LR  K     P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G
Sbjct: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898

Query: 275 NLRQKCV 281
              ++CV
Sbjct: 899 KSYKECV 905



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 58/222 (26%), Positives = 104/222 (46%), Gaps = 25/222 (11%)

Query: 70   DPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALY---LLSPFSVVRRGAIK 126
            D  PEV  +P+E  + Y      F    +G  + RF          L   + ++R+    
Sbjct: 1138 DIKPEVEEVPVEQPEEYLDPDACF---TEG-CVQRFKCCQVNIEEGLGKSWWILRKTCFL 1193

Query: 127  VLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFESLIKILA 178
            ++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E L+K  A
Sbjct: 1194 IVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTA 1253

Query: 179  RGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLRALKTITV 232
             GF      F  + W WLDF ++      ++A    + +LG I +LRT R LR L+ ++ 
Sbjct: 1254 YGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSR 1309

Query: 233  IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
              G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1310 FEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1351



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 47/174 (27%), Positives = 87/174 (50%), Gaps = 12/174 (6%)

Query: 562 APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621
           +P+   + I   I++     + I   I+ N +FM   + P  +   NV       FTGI+
Sbjct: 116 SPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPP--DWSKNV----EYTFTGIY 169

Query: 622 TAEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVF 677
           T E ++K+IA    +D + + +  WN  D  ++ ++ +     N+  +S LR+FR+LR  
Sbjct: 170 TFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYIT-EFVNLGNVSALRTFRVLRAL 228

Query: 678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           K     P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV 282



 Score = 38.1 bits (87), Expect = 0.079
 Identities = 18/72 (25%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  +FL +FR++  ++ E ++     A     +I F++++ +G+  ++NL LA++  +++
Sbjct: 922 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981

Query: 452 EQNEATLAEDKE 463
             N A   +D E
Sbjct: 982 ADNLAATDDDGE 993



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTL---------RAAGKTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    +         +     YM I+FV+ I  GSF+
Sbjct: 1395 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFF 1454

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1455 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1494


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 1748 bits (4527), Expect = 0.0
 Identities = 895/1285 (69%), Positives = 1034/1285 (80%), Gaps = 35/1285 (2%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTF-SEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQP 990
            D +   E+E ++  +E E SK+ P+     + S  STAD     E  E+  +   + + P
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQTPED----SCSEGSTADMTNTAELLEQIPDLGQDVKDP 1110

Query: 991  EECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1050
            E+CFTE CV+R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAF
Sbjct: 1111 EDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAF 1170

Query: 1051 EDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSII 1110
            EDIY+E+R+ I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++
Sbjct: 1171 EDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLV 1230

Query: 1111 SLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIF 1170
            SLVAN LG++E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIF
Sbjct: 1231 SLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIF 1290

Query: 1171 WLIFSIMGVNLFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDN 1229
            WLIFSIMGVNLFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DN
Sbjct: 1291 WLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDN 1350

Query: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289
            VG GYL+LLQVATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNL
Sbjct: 1351 VGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNL 1410

Query: 1290 FIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDL 1349
            FIGVIIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+
Sbjct: 1411 FIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDI 1470

Query: 1350 VTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQ 1409
            VTKQAFD+TIM LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR 
Sbjct: 1471 VTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRH 1530

Query: 1410 YYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIR 1469
            YYFT  WNIFDFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIR
Sbjct: 1531 YYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIR 1590

Query: 1470 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICL 1529
            TLLFALMMSLPALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CL
Sbjct: 1591 TLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCL 1650

Query: 1530 FEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIV 1589
            F+ITTSAGWDGLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIV
Sbjct: 1651 FQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIV 1709

Query: 1590 VNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQE 1649
            VNMYIAIILENF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L E
Sbjct: 1710 VNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSE 1769

Query: 1650 PLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAAN 1709
            PLRIAKPN+I LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAAN
Sbjct: 1770 PLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAAN 1829

Query: 1710 PSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAP 1766
            PSK+SYEPITTTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAP
Sbjct: 1830 PSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAP 1888

Query: 1767 EKEGLLANTMSKMYGHENGNSSSPS 1791
            E+EGL+A  MS+ +    G  SS S
Sbjct: 1889 EREGLIAYVMSENFSRPLGPPSSSS 1913



 Score =  597 bits (1539), Expect = e-170
 Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++ ++ +S         +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1140 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1199

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1200 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1255

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1256 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1304



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
              +  + + +  WN  D  ++ ++ V   +  +  LS LR+FR+LR  K     P L  
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238

Query: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
            GK IF        ++A   L    P  PI R   KI  +V+ L     F++ IM  I  N
Sbjct: 99   GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144

Query: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421
             V  M + D     K      +   F  I+T E ++K+LA    L  + F    WN  DF
Sbjct: 145  CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198

Query: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
             V+I++ V   + L +L             +R  R+ R L+ I    G++T++ AL+ S+
Sbjct: 199  SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
              L ++ +L    + ++++ G+  F    +   +    NF     +         S   D
Sbjct: 248  KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576
            GL+   L+    D +  L   GTS    CGN S  G C
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1347 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1406

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1407 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1446



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 1734 bits (4491), Expect = 0.0
 Identities = 895/1334 (67%), Positives = 1038/1334 (77%), Gaps = 80/1334 (5%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTF-SEPEDSKKPPQPLYDG-------------NSSVCSTADYKPPEEDP 977
            D +   E+E ++  +E E SK+  QP+  G             +++  S A+    + D 
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADW 1114

Query: 978  EEQAEENPEG------------------------------------EQPEECFTEACVQR 1001
             +Q +  P+                                     + PE+CFTE CV+R
Sbjct: 1115 RQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1174

Query: 1002 WPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVI 1061
             PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ I
Sbjct: 1175 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1234

Query: 1062 RTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSE 1121
            + +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++E
Sbjct: 1235 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1294

Query: 1122 LGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1181
            +GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1295 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1354

Query: 1182 FAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQV 1240
            FAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQV
Sbjct: 1355 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV 1414

Query: 1241 ATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1300
            ATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQ
Sbjct: 1415 ATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1474

Query: 1301 QKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIM 1360
            QKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TIM
Sbjct: 1475 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIM 1534

Query: 1361 ILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFD 1420
             LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR YYFT  WNIFD
Sbjct: 1535 FLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFD 1594

Query: 1421 FVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLP 1480
            FVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSLP
Sbjct: 1595 FVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLP 1654

Query: 1481 ALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDG 1540
            ALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWDG
Sbjct: 1655 ALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDG 1714

Query: 1541 LLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILEN 1600
            LL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILEN
Sbjct: 1715 LLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILEN 1773

Query: 1601 FNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIK 1660
            F+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I 
Sbjct: 1774 FSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQIS 1833

Query: 1661 LITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITT 1720
            LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPITT
Sbjct: 1834 LINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITT 1893

Query: 1721 TLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTMS 1777
            TL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  MS
Sbjct: 1894 TLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVMS 1952

Query: 1778 KMYGHENGNSSSPS 1791
            + +    G  SS S
Sbjct: 1953 ENFSRPLGPPSSSS 1966



 Score =  602 bits (1551), Expect = e-171
 Identities = 306/478 (64%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGN+SALRTFRVLRALKTI+VI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1357



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 46/167 (27%), Positives = 84/167 (50%), Gaps = 22/167 (13%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFD-SIIV---TLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWP 684
              +  + + +  WN  D S+I+   T   V+LG      +S LR+FR+LR  K      
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-----NVSALRTFRVLRALKTISVIS 234

Query: 685 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
            L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 235 GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1400 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1459

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1460 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 1731 bits (4484), Expect = 0.0
 Identities = 894/1335 (66%), Positives = 1036/1335 (77%), Gaps = 81/1335 (6%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTFSEPEDSKKPP--QPLYDG-------------NSSVCSTADYKPPEED 976
            D +   E+E ++    E+S K    QP+  G             +++  S A+    + D
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQAD 1114

Query: 977  PEEQAEENPEG------------------------------------EQPEECFTEACVQ 1000
              +Q +  P+                                     + PE+CFTE CV+
Sbjct: 1115 WRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVR 1174

Query: 1001 RWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRV 1060
            R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ 
Sbjct: 1175 RCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1234

Query: 1061 IRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
            I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++
Sbjct: 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294

Query: 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1180
            E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVN
Sbjct: 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1354

Query: 1181 LFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
            LFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQ
Sbjct: 1355 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1414

Query: 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1299
            VATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1415 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1474

Query: 1300 QQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITI 1359
            QQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TI
Sbjct: 1475 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1534

Query: 1360 MILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIF 1419
            M LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR YYFT  WNIF
Sbjct: 1535 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594

Query: 1420 DFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
            DFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSL
Sbjct: 1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            PALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWD
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1714

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            GLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILE
Sbjct: 1715 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1773

Query: 1600 NFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKI 1659
            NF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I
Sbjct: 1774 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1833

Query: 1660 KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPIT 1719
             LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPIT
Sbjct: 1834 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1893

Query: 1720 TTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTM 1776
            TTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  M
Sbjct: 1894 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVM 1952

Query: 1777 SKMYGHENGNSSSPS 1791
            S+ +    G  SS S
Sbjct: 1953 SENFSRPLGPPSSSS 1967



 Score =  602 bits (1551), Expect = e-171
 Identities = 306/478 (64%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGN+SALRTFRVLRALKTI+VI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1358



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 46/167 (27%), Positives = 84/167 (50%), Gaps = 22/167 (13%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFD-SIIV---TLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWP 684
              +  + + +  WN  D S+I+   T   V+LG      +S LR+FR+LR  K      
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-----NVSALRTFRVLRALKTISVIS 234

Query: 685 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
            L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 235 GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1460

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1461 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 1731 bits (4484), Expect = 0.0
 Identities = 894/1335 (66%), Positives = 1036/1335 (77%), Gaps = 81/1335 (6%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTFSEPEDSKKPP--QPLYDG-------------NSSVCSTADYKPPEED 976
            D +   E+E ++    E+S K    QP+  G             +++  S A+    + D
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQAD 1114

Query: 977  PEEQAEENPEG------------------------------------EQPEECFTEACVQ 1000
              +Q +  P+                                     + PE+CFTE CV+
Sbjct: 1115 WRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVR 1174

Query: 1001 RWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRV 1060
            R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ 
Sbjct: 1175 RCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1234

Query: 1061 IRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
            I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++
Sbjct: 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294

Query: 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1180
            E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVN
Sbjct: 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1354

Query: 1181 LFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
            LFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQ
Sbjct: 1355 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1414

Query: 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1299
            VATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1415 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1474

Query: 1300 QQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITI 1359
            QQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TI
Sbjct: 1475 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1534

Query: 1360 MILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIF 1419
            M LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR YYFT  WNIF
Sbjct: 1535 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1594

Query: 1420 DFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
            DFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSL
Sbjct: 1595 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1654

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            PALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWD
Sbjct: 1655 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1714

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            GLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILE
Sbjct: 1715 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1773

Query: 1600 NFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKI 1659
            NF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I
Sbjct: 1774 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1833

Query: 1660 KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPIT 1719
             LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPIT
Sbjct: 1834 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1893

Query: 1720 TTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTM 1776
            TTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  M
Sbjct: 1894 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVM 1952

Query: 1777 SKMYGHENGNSSSPS 1791
            S+ +    G  SS S
Sbjct: 1953 SENFSRPLGPPSSSS 1967



 Score =  597 bits (1539), Expect = e-170
 Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++ ++ +S         +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1358



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
              +  + + +  WN  D  ++ ++ V   +  +  LS LR+FR+LR  K     P L  
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238

Query: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
            GK IF        ++A   L    P  PI R   KI  +V+ L     F++ IM  I  N
Sbjct: 99   GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144

Query: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421
             V  M + D     K      +   F  I+T E ++K+LA    L  + F    WN  DF
Sbjct: 145  CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198

Query: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
             V+I++ V   + L +L             +R  R+ R L+ I    G++T++ AL+ S+
Sbjct: 199  SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
              L ++ +L    + ++++ G+  F    +   +    NF     +         S   D
Sbjct: 248  KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576
            GL+   L+    D +  L   GTS    CGN S  G C
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1401 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1460

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1461 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1500



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 1686 bits (4366), Expect = 0.0
 Identities = 877/1335 (65%), Positives = 1019/1335 (76%), Gaps = 99/1335 (7%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTFSEPEDSKKPP--QPLYDG-------------NSSVCSTADYKPPEED 976
            D +   E+E ++    E+S K    QP+  G             +++  S A+    + D
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQAD 1114

Query: 977  PEEQAEENPEG------------------------------------EQPEECFTEACVQ 1000
              +Q +  P+                                     + PE+CFTE CV+
Sbjct: 1115 WRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVR 1174

Query: 1001 RWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRV 1060
            R PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ 
Sbjct: 1175 RCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKT 1234

Query: 1061 IRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYS 1120
            I+ +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++
Sbjct: 1235 IKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFA 1294

Query: 1121 ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1180
            E+GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVN
Sbjct: 1295 EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1354

Query: 1181 LFAGKFYYCINTTTSER-FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQ 1239
            LFAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQ
Sbjct: 1355 LFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQ 1414

Query: 1240 VATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1299
            V                   EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1415 VY------------------EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1456

Query: 1300 QQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITI 1359
            QQKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TI
Sbjct: 1457 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1516

Query: 1360 MILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIF 1419
            M LICLNMVTMMVETD+QS  K++IL  IN++F+ IFTGEC++K+ ALR YYFT  WNIF
Sbjct: 1517 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1576

Query: 1420 DFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
            DFVVVILSIVG  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSL
Sbjct: 1577 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1636

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            PALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWD
Sbjct: 1637 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1696

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            GLL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILE
Sbjct: 1697 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1755

Query: 1600 NFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKI 1659
            NF+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I
Sbjct: 1756 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1815

Query: 1660 KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPIT 1719
             LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPIT
Sbjct: 1816 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1875

Query: 1720 TTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTM 1776
            TTL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  M
Sbjct: 1876 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVM 1934

Query: 1777 SKMYGHENGNSSSPS 1791
            S+ +    G  SS S
Sbjct: 1935 SENFSRPLGPPSSSS 1949



 Score =  597 bits (1539), Expect = e-170
 Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++ ++ +S         +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1194 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1253

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1254 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1309

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1310 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1358



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
              +  + + +  WN  D  ++ ++ V   +  +  LS LR+FR+LR  K     P L  
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238

Query: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
            GK IF        ++A   L    P  PI R   KI  +V+ L     F++ IM  I  N
Sbjct: 99   GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144

Query: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421
             V  M + D     K      +   F  I+T E ++K+LA    L  + F    WN  DF
Sbjct: 145  CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198

Query: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
             V+I++ V   + L +L             +R  R+ R L+ I    G++T++ AL+ S+
Sbjct: 199  SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
              L ++ +L    + ++++ G+  F    +   +    NF     +         S   D
Sbjct: 248  KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576
            GL+   L+    D +  L   GTS    CGN S  G C
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955



 Score = 36.6 bits (83), Expect = 0.23
 Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 12/92 (13%)

Query: 388  SYDTFSWAFLALFRLMT-QDYWE-NLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAV 445
            ++D     +LAL ++   Q  WE NL+            I+FV+ I  GSF+ +NL + V
Sbjct: 1401 NFDNVGAGYLALLQVYEEQPQWEYNLYMY----------IYFVIFIIFGSFFTLNLFIGV 1450

Query: 446  VAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
            +   + +Q +    +D    EE ++     KK
Sbjct: 1451 IIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1482


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 1665 bits (4312), Expect = 0.0
 Identities = 870/1334 (65%), Positives = 1010/1334 (75%), Gaps = 112/1334 (8%)

Query: 516  EKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            E GA +++ S  S ++ A+EELEE+  KCPP W + A + LIW CC  W+  K  + L+V
Sbjct: 655  EPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVV 714

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPY 635
            MDPF DL IT+CIVLNTLFMA+EHY MT  F+ +L VGNLVFTGIFTAEM  K+IA+DPY
Sbjct: 715  MDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPY 774

Query: 636  EYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 695
             YFQQGWNIFDSIIV LSL+ELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGN
Sbjct: 775  YYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGN 834

Query: 696  SVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVF 755
            SVGALGNLTLVLAIIVFIFAVVGMQLFGK+Y E   + +    LPRWHM DFFH+FLI+F
Sbjct: 835  SVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIF 892

Query: 756  RILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
            RILCGEWIETMWDCMEV+GQ++CL VFL+VMVIGNLVVLNLFLALLLSSFSAD+L A DE
Sbjct: 893  RILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDE 952

Query: 816  DGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKILSPKDIMLSLGEADGAGEAGEAG 871
            D EMNNLQ+A+ RI+ G+ F K     F  GLL  +   P   + + G+      A    
Sbjct: 953  DREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPA-ALAAQGQLPSC-IATPYS 1010

Query: 872  ETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEES 931
               PE EK  P  ++ + +       G    P                  + VPIA  ES
Sbjct: 1011 PPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP----------------VCVPIAVAES 1054

Query: 932  DLEMPTEEETDTF-SEPEDSKKPPQPLYDG-------------NSSVCSTADYKPPEEDP 977
            D +   E+E ++  +E E SK+  QP+  G             +++  S A+    + D 
Sbjct: 1055 DTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADW 1114

Query: 978  EEQAEENPEG------------------------------------EQPEECFTEACVQR 1001
             +Q +  P+                                     + PE+CFTE CV+R
Sbjct: 1115 RQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1174

Query: 1002 WPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVI 1061
             PC  VD +Q  GK WW LR+ C+ IVEH+WFETFI+FMILLSSGALAFEDIY+E+R+ I
Sbjct: 1175 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1234

Query: 1062 RTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSE 1121
            + +LEYADK+FTY+F++EMLLKWVAYGFK YFTNAWCWLDFLIVDVS++SLVAN LG++E
Sbjct: 1235 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1294

Query: 1122 LGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1181
            +GPIKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1295 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1354

Query: 1182 FAGKFYYCINTTTSE-RFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQV 1240
            FAGKF  CIN T  +   + + VNNKS+CESL  TG++ W  VKVN+DNVG GYL+LLQV
Sbjct: 1355 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQV 1414

Query: 1241 ATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1300
            ATFKGWMDIMYAAVDSR  EEQPQ+E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQ
Sbjct: 1415 ATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1474

Query: 1301 QKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIM 1360
            QKKKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG ++D+VTKQAFD+TIM
Sbjct: 1475 QKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIM 1534

Query: 1361 ILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFD 1420
             LICLNMVTMMVETD+QS  K++IL  IN++F+ IFT                       
Sbjct: 1535 FLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT----------------------- 1571

Query: 1421 FVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLP 1480
                     G  LSD+IQKYF SPTLFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSLP
Sbjct: 1572 ---------GTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLP 1622

Query: 1481 ALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDG 1540
            ALFNIGLLLFLVMFIYSIFGM+NFAYVK E+GIDDMFNF+TF NS++CLF+ITTSAGWDG
Sbjct: 1623 ALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDG 1682

Query: 1541 LLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILEN 1600
            LL+PILN+GPP CDP L N   S +GDCG+P++GI FF +YIIISFLIVVNMYIAIILEN
Sbjct: 1683 LLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILEN 1741

Query: 1601 FNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIK 1660
            F+VATEES+EPL EDDF+MFYE WEKFDP+ATQFI YS LSDF D L EPLRIAKPN+I 
Sbjct: 1742 FSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQIS 1801

Query: 1661 LITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITT 1720
            LI +DLPMV GD+IHC+DILFA TK VLG+SGEMDALK  MEEKFMAANPSK+SYEPITT
Sbjct: 1802 LINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITT 1861

Query: 1721 TLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSG---DDAPEKEGLLANTMS 1777
            TL+RKHEEV A+ IQRA+RRHLLQRS+K AS+++R    GSG   +DAPE+EGL+A  MS
Sbjct: 1862 TLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR-QQAGSGLSEEDAPEREGLIAYVMS 1920

Query: 1778 KMYGHENGNSSSPS 1791
            + +    G  SS S
Sbjct: 1921 ENFSRPLGPPSSSS 1934



 Score =  597 bits (1539), Expect = e-170
 Identities = 303/478 (63%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 91.3 bits (225), Expect = 8e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++ ++ +S         +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVS------ENIKLGNLSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 44/169 (26%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171
            +R+    ++ H+ F  FI+  IL +   +   D     +      +EY    FT ++  E
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252

Query: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225
             L+K +A GF      +  + W WLDF ++      ++A    F ++G I +LRT R LR
Sbjct: 1253 MLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALR 1308

Query: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 1309 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1357



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 45/163 (27%), Positives = 84/163 (51%), Gaps = 11/163 (6%)

Query: 120 VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYTFESL 173
           +++G   V++     + I + I+ N +FM +      S+  E        FTGI+T E  
Sbjct: 706 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765

Query: 174 IKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD-LGNISALRTFRVLRALKTITV 232
            KI+A    +D + + +  WN  D  +++++ +   +  + N+S LR+FR+LR  K    
Sbjct: 766 FKIIA----LDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKS 821

Query: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGN 275
            P L T++  +  SV  L ++ ++    + +FA+VG+QLF  N
Sbjct: 822 WPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKN 864



 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 14/163 (8%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNM 688
              +  + + +  WN  D  ++ ++ V   +  +  LS LR+FR+LR  K     P L  
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI-KLGNLSALRTFRVLRALKTISVIPGLKT 238

Query: 689 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
           ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 239 IVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 1307 GKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLN 1366
            GK IF        ++A   L    P  PI R   KI  +V+ L     F++ IM  I  N
Sbjct: 99   GKTIFR-------FSATNALYVLSPFHPIRRAAVKI--LVHSL-----FNMLIMCTILTN 144

Query: 1367 MVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLA----LRQYYFTVG-WNIFDF 1421
             V  M + D     K      +   F  I+T E ++K+LA    L  + F    WN  DF
Sbjct: 145  CV-FMAQHDPPPWTKY-----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDF 198

Query: 1422 VVVILSIV--GLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSL 1479
             V+I++ V   + L +L             +R  R+ R L+ I    G++T++ AL+ S+
Sbjct: 199  SVIIMAYVSENIKLGNL-----------SALRTFRVLRALKTISVIPGLKTIVGALIQSV 247

Query: 1480 PALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWD 1539
              L ++ +L    + ++++ G+  F    +   +    NF     +         S   D
Sbjct: 248  KKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGT-------NGSVEAD 297

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPS-IGIC 1576
            GL+   L+    D +  L   GTS    CGN S  G C
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTC 335



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1400 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1459

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1460 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1499



 Score = 38.9 bits (89), Expect = 0.047
 Identities = 17/72 (23%), Positives = 41/72 (56%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  AFL +FR++  ++ E ++     +     ++ F++++ +G+  ++NL LA++  +++
Sbjct: 884 FFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943

Query: 452 EQNEATLAEDKE 463
             N     ED+E
Sbjct: 944 ADNLTAPDEDRE 955


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1605 bits (4156), Expect = 0.0
 Identities = 854/1763 (48%), Positives = 1141/1763 (64%), Gaps = 109/1763 (6%)

Query: 14   PECLRPFTRESLAAIEQRAVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGDPPP 73
            P+ L PFT+ES   I+Q        + +    + EE + KP  DLE GK LP IYG+   
Sbjct: 7    PKGLVPFTKESFELIKQH-------IAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQ 59

Query: 74   EVIGIPLEDLDPYYSNKK-TFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHAL 132
             ++  PLED+DPYY  KK TFIVLNK + IFRF+A   L  LSPF+ +RR  IKVL+H  
Sbjct: 60   GMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPF 119

Query: 133  FSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDP 192
            F +FI+I++L +CVFM++++ P W   +E T  GIYTFE L+K+ ARG     F+FL DP
Sbjct: 120  FQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDP 179

Query: 193  WNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSD 252
            WNWLDFSV +   +  +  L  I  L+T R LR LK I +  GLK++VG LI  +K+L  
Sbjct: 180  WNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIG 239

Query: 253  VMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMW 312
            V+ILT+F LS+F+L+G+ LFMGNL+ KC RWP            N+T +           
Sbjct: 240  VIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE--------NENETLH----------- 280

Query: 313  YGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEG 372
                    N T N +             YI +  NFY+LEG   ALLCGN +DAG CPEG
Sbjct: 281  --------NRTGNPY-------------YIRETENFYYLEGERYALLCGNRTDAGQCPEG 319

Query: 373  YECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIF 432
            Y C+K G NP+ G+T++D+F WA  ALFRLM QDY E L+   L A+GK YMIFFVV+ F
Sbjct: 320  YVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSF 379

Query: 433  LGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALE 492
            L SFY+ +L L ++AMAY E+ +      K+ E +FQQ  ++ ++  E  ++AK  Q   
Sbjct: 380  LFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNET-DEAKTIQI-- 436

Query: 493  GGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAM----EELEEAHQKCPPWW 548
                                 + +K +P  + +    + DA     EELE++ + CP +W
Sbjct: 437  ---------------------EMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYW 475

Query: 549  YKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN 608
            YK A   LIWNC   WLK K  +H I+M PF DL + ICI+LN  F+ +EHYPM++  + 
Sbjct: 476  YKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNT 535

Query: 609  VLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVL 668
            +L +GNLVF GIFTAEM+ K+IAM PY YFQ GWNIFDS+IV   L+EL LANV G+++L
Sbjct: 536  LLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALL 595

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKE 728
            R FR+LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LFGK+Y+E
Sbjct: 596  RLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEE 655

Query: 729  CVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVI 788
             VC I  DC LPRWHMHDFFHSFL VFRILCGEW+ET+WDCMEVAGQ+ C+  +LMV++I
Sbjct: 656  FVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILI 715

Query: 789  GNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKI 848
            GNL+VL LFLAL+ SSFS+     ++E+ E  NLQ+A+ RIK GI +    LL +L    
Sbjct: 716  GNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYV---LLKILCKTQ 771

Query: 849  LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPP-SSL 907
              PKD M                E   +++  +    +L      L     + G   ++ 
Sbjct: 772  NVPKDTM------------DHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNAT 819

Query: 908  ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST 967
            E +  + I +P ++  VPIAS ESD+E    +E  + S    SK   + +   +SS CST
Sbjct: 820  ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSK---EKIKQSSSSECST 876

Query: 968  ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKI 1027
             D    EE      EE   G +  +     C +      +  +  +GK W  +R+ C KI
Sbjct: 877  VDIAISEE------EEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKI 930

Query: 1028 VEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAY 1087
            VE+NWF+ FI  + LLS+G LAFEDIY++QR+ I+ +LEYAD +FTYIFI+EMLLKW+AY
Sbjct: 931  VENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAY 990

Query: 1088 GFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMR 1147
            GFK YF+N W  LDF++V V  +SL+       EL P+ S++ LR   PLR LS+FE M+
Sbjct: 991  GFKAYFSNGWYRLDFVVVIVFCLSLIGKTR--EELKPLISMKFLR---PLRVLSQFERMK 1045

Query: 1148 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKS 1207
            VVV AL+      +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+ ERF  SEV NKS
Sbjct: 1046 VVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKS 1105

Query: 1208 ECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEV 1267
             CESL+    + W N K+N+DNVG G+LSLLQVATF GW+ IM +A+DS     QP +EV
Sbjct: 1106 RCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEV 1165

Query: 1268 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLG 1327
            N+YMY YF+ FIIFG F  L++ I VIIDNFN+ K KLGG +IF+T +Q+K Y  +KKL 
Sbjct: 1166 NIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLM 1225

Query: 1328 SKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYN 1387
             +  Q+P+PRP NK+QG ++D+VT QAF++ +M+LIC   + MM++TD QS      LY 
Sbjct: 1226 YEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYW 1285

Query: 1388 INMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLF 1447
            IN IF++++T EC+LK++A R +YFT+ WNIFDF+VVI SI GL L   +  Y V P+L 
Sbjct: 1286 INSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLV 1345

Query: 1448 RVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYV 1507
            ++I L+RI  +LRL +G K    L+  LM+SLPAL NI LL+FLVMFIY++FGM NFAYV
Sbjct: 1346 QLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV 1405

Query: 1508 KKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGD 1567
            KKE+GI+D+ NFETFGNS++CLF++   AGWDG+L+ I NS   DCDP+  NPGT V+GD
Sbjct: 1406 KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGD 1465

Query: 1568 CGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKF 1627
            CGNPS+GI +F SYI+IS+LI+VNMYI +++E  N+A+++ ++ L EDDF  F++ W++F
Sbjct: 1466 CGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRF 1525

Query: 1628 DPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEV 1687
            DPD TQ+I  S+LSDF   L  PL +AKPNK +LI LDLPM  GD+IHCLDIL A TK V
Sbjct: 1526 DPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRV 1585

Query: 1688 LGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSM 1747
            +G    M+ +   +E  F+ ANP K++ EPITTTLKRK E V A  IQRAY+ + L+R+ 
Sbjct: 1586 MGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRND 1645

Query: 1748 KQASYMYRHSHDGSGDDAPEKEG 1770
            K  S +  H  DG  D    KEG
Sbjct: 1646 KNTSDI--HMIDGDRDVHATKEG 1666


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1605 bits (4156), Expect = 0.0
 Identities = 904/1834 (49%), Positives = 1177/1834 (64%), Gaps = 207/1834 (11%)

Query: 18   RPFTRESLAAIEQR-AVEEEARLQRNKQMEIEEPERKPRSDLEAGKNLPMIYGDPPPEVI 76
            RPFT +SLAAIE+R A+++E +  +++  E+ +P  +P+ DL+A + LP +YGD P E+I
Sbjct: 17   RPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQP--RPQLDLKASRKLPKLYGDIPRELI 74

Query: 77   GIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFSMF 136
            G PLEDLDP+Y N KTF+VLN+ + I+RFSA  AL++  PF+ +R  AI+V +H+LFSMF
Sbjct: 75   GKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLFSMF 134

Query: 137  IMITILTNCVFMTMSDPPPWSKN----VEYTFTGIYTFESLIKILARGFCVDDFTFLRDP 192
            I+ T++ NCVFM        + N     E  FTGIY FE+LIKILARGF +D+F+FLRDP
Sbjct: 135  IIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDP 194

Query: 193  WNWLDFSVIMMAYLTEFVDLG-NISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLS 251
            WNWLD  VI +A ++    +   +  LRTFRV RALK I+V+  LK IVGAL++SVKK  
Sbjct: 195  WNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKK-- 252

Query: 252  DVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEM 311
               ++ V  L+ F    L +F                                   G ++
Sbjct: 253  ---LVNVIILTFFC---LSIF--------------------------------ALVGQQL 274

Query: 312  WYG--NDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHC 369
            + G  N    + D  N     A +  F+              E S +  +CG       C
Sbjct: 275  FMGSLNLKCISRDCKNISNPEAYDHCFEKK------------ENSPEFKMCGIWMGNSAC 322

Query: 370  PEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVV 429
               YEC  T  NP+Y YT++D F W+FLA+FRLMTQD WE L+Q TLR  G   + FF+V
Sbjct: 323  SIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIV 382

Query: 430  IIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL------- 482
            +IFLGSFYLINL LAVV MAY EQN+   AE + KE+ FQ+  +  K+ +E L       
Sbjct: 383  VIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDR 442

Query: 483  ---------------------EKAKAAQALEGGEADGDPAHG--KDC------------- 506
                                 +K K+    E G+ D  P     +DC             
Sbjct: 443  SSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK-DQPPGSDSDEDCQKKPQLLEQTKRL 501

Query: 507  --NGSLDTSQGEKGAPRQSSSGDSGISD---AMEELEEAHQKCPPWWYKCAHKVLIWNCC 561
              N SLD    E G P Q     S +S     M+E E++ + C P     A K L+WNCC
Sbjct: 502  SQNLSLDHFD-EHGDPLQRQRALSAVSILTITMKEQEKSQEPCLPCGENLASKYLVWNCC 560

Query: 562  APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621
              WL  K ++  ++ DPF +L ITICI++NT+F+AMEH+ M   F+ +L +GNLVFT IF
Sbjct: 561  PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIF 620

Query: 622  TAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLS--VLRSFRLLRVFKL 679
             AEM LK+IA+DPY YF++GWNIFDSI+  LS  ++    +Q  S   LRSFR+LRVFKL
Sbjct: 621  IAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKL 680

Query: 680  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN- 738
            AKSWPTLN LIKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+     K    CN 
Sbjct: 681  AKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ--KSPKLCNP 738

Query: 739  -------LPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAG--QAMCLTVFLMVMVIG 789
                   L  WHM DF+HSFL+VFRILCGEWIE MW+CM+ A    ++C+ VF+++ VIG
Sbjct: 739  TGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIG 798

Query: 790  NLVVLNLFLALLLSSFSADSLAASDE-DGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKI 848
             LVVLNLF+ALLL+SFS +    + E +     +Q+A+ R +    F +  L    H K 
Sbjct: 799  KLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCH-KW 857

Query: 849  LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLE 908
               +++           +   AG  A + +   P   ++K+ +     +G+    P +L 
Sbjct: 858  CRKQNL---------PQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLG 908

Query: 909  LDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPE----------DSKKP----- 953
            + H         T   P+A EE D+E   E+     ++PE          ++KKP     
Sbjct: 909  VRH-------DWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRV 961

Query: 954  -------------------PQPLYDGNS--SVCSTADYKPPEEDPEEQAEENPEGEQPEE 992
                               P+   D  S  S CST D     +D      E    +QPE 
Sbjct: 962  QSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL----QDGFGWLPEMVPKKQPER 1017

Query: 993  CFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFED 1052
            C  +     +PC  VD  +     WW LR+ C++IV+H+WFE+FI+F+ILLSSGAL FED
Sbjct: 1018 CLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFED 1077

Query: 1053 IYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISL 1112
            +++E +  I+ +L   D +FT+IFI+EM+LKWVA+GF  YFT+AWC LDF+IV VS+ +L
Sbjct: 1078 VHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTL 1137

Query: 1113 VANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
            +        L  +KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL
Sbjct: 1138 I-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWL 1190

Query: 1173 IFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGL 1232
            +F I+GV  F+GKF  CIN T S   + + + NKS+CES    G   W+N KVN+DNVG 
Sbjct: 1191 VFCILGVYFFSGKFGKCINGTDSV-INYTIITNKSQCES----GNFSWINQKVNFDNVGN 1245

Query: 1233 GYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIG 1292
             YL+LLQVATFKGWMDI+YAAVDS EKE+QP++E N   Y+YFV+FIIFGSFFTLNLFIG
Sbjct: 1246 AYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIG 1305

Query: 1293 VIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTK 1352
            VIIDNFNQQ+KKLGG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+V+D+VT 
Sbjct: 1306 VIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTS 1365

Query: 1353 QAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYF 1412
            Q FDI I+ LI LNM++MM E+ NQ +    IL ++N +F++IFT EC++K+ ALRQYYF
Sbjct: 1366 QIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYF 1425

Query: 1413 TVGWNIFDFVVVILSIVGLALSDLIQKYFV--SPTLFRVIRLARIGRVLRLIRGAKGIRT 1470
            T GWN+FD VVV+LSIV   +S L  +  +   PTLFR++RLARIGR+LRL+R A+GIRT
Sbjct: 1426 TNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRT 1485

Query: 1471 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLF 1530
            LLFALMMSLP+LFNIGLLLFL+MFIY+I GM+ F+ V  ESGIDD+FNF+TF +S++CLF
Sbjct: 1486 LLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLF 1545

Query: 1531 EITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVV 1590
            +I+TSAGWD LL+P+L S    C+ + EN        C  P I   +F SYIIISFLIVV
Sbjct: 1546 QISTSAGWDSLLSPMLRS-KESCNSSSEN--------CHLPGIATSYFVSYIIISFLIVV 1596

Query: 1591 NMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEP 1650
            NMYIA+ILENFN ATEES +PLGEDDF++FYE WEKFDP+ATQFI YS LSDF D L EP
Sbjct: 1597 NMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEP 1656

Query: 1651 LRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANP 1710
            LR+AKPNK + + +DLPMV  D++HC+DILFA T  VLG S  +D++K  MEEKFM ANP
Sbjct: 1657 LRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANP 1716

Query: 1711 SKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQ 1744
             K  YEPI TT KRK EE  A  IQ+A+R+++++
Sbjct: 1717 LKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK 1750


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 1557 bits (4032), Expect = 0.0
 Identities = 805/1276 (63%), Positives = 961/1276 (75%), Gaps = 79/1276 (6%)

Query: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589
            I+  +EELEE+ QKCPP     + K LIW+CC  W+K K I+  +V DPF +L IT+CIV
Sbjct: 617  ITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIV 676

Query: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649
            +NT+FMAMEH+ M+  F+ +L +GN+VFT  FTAEMV K+IA DPY YFQ+ WNIFD II
Sbjct: 677  VNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCII 736

Query: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709
            VT+SL+ELG+A    LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAI
Sbjct: 737  VTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAI 796

Query: 710  IVFIFAVVGMQLFGKSYKECVCKIALDC-NLPRWHMHDFFHSFLIVFRILCGEWIETMWD 768
            IVF+FA+VG QL G++Y+     I+    + PRWHMHDFFHSFLIVFRILCGEWIE MW 
Sbjct: 797  IVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWA 856

Query: 769  CMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGR 828
            CMEV  +++CL +FL VMV+GNLVVLNLF+ALLL+SFSAD+L A ++DGE+NNLQ+A+ R
Sbjct: 857  CMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALAR 916

Query: 829  IKLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLK 888
            I++     K  L          P+                   +  PE   K P     K
Sbjct: 917  IQVFGHRTKQALCSFFSRSCPFPQP------------------KAEPELVVKLPLSSS-K 957

Query: 889  KDNHILNHM--GLADG--PPSSLELDHLNFINNPYLTIQVPIASEESDLE---------- 934
             +NHI  +   G + G   P     +H +FI NP + + VPIA  ESDL+          
Sbjct: 958  AENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDA 1017

Query: 935  --------------------------MPTEEETDTFSEP---------EDSKKPPQP--- 956
                                       P    T T SE          +D   P  P   
Sbjct: 1018 QSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEG 1077

Query: 957  LYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKK 1016
            + D +SS  ST D   PEE   +  E   + E+P++CFTE C++  PC  +D ++     
Sbjct: 1078 VDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDV 1137

Query: 1017 WWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIF 1076
             W +R+ C++IVEH+WFE+FI+FMILLSSG+LAFED Y++Q+  ++ +LEY D+VFT+IF
Sbjct: 1138 GWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIF 1197

Query: 1077 IMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRP 1136
            + EMLLKWVAYGFK YFTNAWCWLDFLIV++S+ISL A  L YSE+ PIK+LRTLRALRP
Sbjct: 1198 VFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRP 1257

Query: 1137 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSE 1196
            LRALSRFEGMRVVV+AL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CIN T  E
Sbjct: 1258 LRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGE 1317

Query: 1197 --RFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAV 1254
                 +S VNNKS+C+    TG   W+NVKVN+DNV +GYL+LLQVATFKGWMDIMYAAV
Sbjct: 1318 FSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAV 1377

Query: 1255 DSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTE 1314
            DSRE   QP++E N+YMYLYFVIFIIFG FFTLNLF+GVIIDNFNQQKKKLGG+DIFMTE
Sbjct: 1378 DSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTE 1437

Query: 1315 EQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVET 1374
            EQKKYYNAMKKLGSKKPQKPIPRP NK QG V+D+VT+QAFDITIM+LICLNM+TMMVET
Sbjct: 1438 EQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVET 1497

Query: 1375 DNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALS 1434
            D+QS+ K  IL  IN  F+ +FTGECV+KM ALRQYYFT GWN+FDF+VV+LSI  L  S
Sbjct: 1498 DDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFS 1557

Query: 1435 DL---IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFL 1491
             +   +Q YF SPTLFRVIRLARIGR+LRLIR AKGIRTLLFALMMSLPALFNIGLLLFL
Sbjct: 1558 AILKSLQSYF-SPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFL 1616

Query: 1492 VMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPP 1551
            VMFIYSIFGMS+F +V+ E+GIDDMFNF+TF NS++CLF+ITTSAGWDGLL+PILN+GPP
Sbjct: 1617 VMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPP 1676

Query: 1552 DCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEP 1611
             CDPNL N     +GDCG+P++GI FF +YIIISFLI+VNMYIA+ILENFNVATEES+EP
Sbjct: 1677 YCDPNLPN-SNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEP 1735

Query: 1612 LGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPG 1671
            L EDDF+MFYETWEKFDP+ATQFI +S LSDF DTL  PLRI KPN+  LI +DLP+VPG
Sbjct: 1736 LSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPG 1795

Query: 1672 DKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCA 1731
            DKIHCLDILFA TK VLG+SGE+D+LK  MEEKFMA N SK SYEPI TTL+ K E++ A
Sbjct: 1796 DKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISA 1855

Query: 1732 IKIQRAYRRHLLQRSM 1747
              IQ+AYR ++L RSM
Sbjct: 1856 TVIQKAYRSYVLHRSM 1871



 Score =  496 bits (1276), Expect = e-139
 Identities = 263/468 (56%), Positives = 328/468 (70%), Gaps = 52/468 (11%)

Query: 18  RPFTRESLAAIEQR-AVEEEARLQRNKQMEIEEPERKPRS--DLEAGKNLPMIYGDPPPE 74
           R FT ESL  IE++ A ++  +  R K  E ++ E KPR   DL+A   LP  YG+ P E
Sbjct: 14  RRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELPAE 73

Query: 75  VIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHALFS 134
           +IG PLEDLDP+YS  +TF+VLNKG+ I RFSAT AL+L SPF+++RR AIKV +H+ FS
Sbjct: 74  LIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFS 133

Query: 135 MFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWN 194
           +FI +TIL NCV MT +D P   + +EY FT IYTFE+LIKILARGFC+++FT+LRDPWN
Sbjct: 134 LFITVTILVNCVCMTRTDLP---EKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWN 190

Query: 195 WLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVM 254
           WLDFSVI +AY+   +DL  IS LRTFRVLRALKT++VIPGLK IVGALI SVKKL+DV 
Sbjct: 191 WLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVT 250

Query: 255 ILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYG 314
           ILT+FCLSVFALVGLQLF GNL+ KCV+     N+T                        
Sbjct: 251 ILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETT----------------------- 287

Query: 315 NDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYE 374
                    ++SH           D YI+         G++D LLCGN SD+GHCP+GY 
Sbjct: 288 --------NYSSHRK--------PDIYINK-------RGTSDPLLCGNGSDSGHCPDGYI 324

Query: 375 CIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLG 434
           C+KT  NP++ YTS+D+F+WAFL+LFRLMTQD WE L+Q TLR +GK YMIFFV++IFLG
Sbjct: 325 CLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLG 384

Query: 435 SFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           SFYL+NLILAVV MAY EQN+AT  E + KE++FQ+ LE  +K QE L
Sbjct: 385 SFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVL 432



 Score =  101 bits (251), Expect = 8e-21
 Identities = 82/337 (24%), Positives = 155/337 (45%), Gaps = 60/337 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RR   K+  H+WF  FI   IL++   +   D+            E  + VFT I+  E
Sbjct: 119  IRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLP-----------EKIEYVFTVIYTFE 167

Query: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF +    Y  + W WLDF ++ ++ +    +  G      I  LRT R LR
Sbjct: 168  ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRG------ISGLRTFRVLR 221

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG-------KFYY 1188
             L+ +S   G++V+V AL+ ++  + +V ++ +    +F+++G+ LF G       K   
Sbjct: 222  ALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDM 281

Query: 1189 CINTTT---SERFDISEVNNKSECESLM-----HTGQV--RWLNVK---------VNYDN 1229
             +N TT   S R     +N +   + L+      +G     ++ +K          ++D+
Sbjct: 282  AVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341

Query: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289
                +LSL ++ T   W  +    + +  K         +YM ++FV+ I  GSF+ +NL
Sbjct: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGK---------IYM-IFFVLVIFLGSFYLVNL 391

Query: 1290 FIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKL 1326
             + V+   + +Q +    +   +  ++KK+  A++ L
Sbjct: 392  ILAVVTMAYEEQNQATTDE---IEAKEKKFQEALEML 425



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 53/186 (28%), Positives = 98/186 (52%), Gaps = 22/186 (11%)

Query: 115  SPFSV---VRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-----PPPWSKNVEYT--- 163
            SP+ V   VR+   +++ H+ F  FI+  IL +   +   D      P     +EYT   
Sbjct: 1133 SPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRV 1192

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISA 217
            FT I+ FE L+K +A GF      +  + W WLDF ++      + A + E+ ++  I A
Sbjct: 1193 FTFIFVFEMLLKWVAYGFK----KYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKA 1248

Query: 218  LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLR 277
            LRT R LR L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 1249 LRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 1307

Query: 278  QKCVRW 283
             +C+ +
Sbjct: 1308 WRCINY 1313



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 67/287 (23%), Positives = 127/287 (44%), Gaps = 63/287 (21%)

Query: 582 LGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA----MDPYEY 637
           L IT+ I++N + M     P    +         VFT I+T E ++K++A    ++ + Y
Sbjct: 134 LFITVTILVNCVCMTRTDLPEKIEY---------VFTVIYTFEALIKILARGFCLNEFTY 184

Query: 638 FQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSV 697
            +  WN  D  ++TL+ V   + +++G+S LR+FR+LR  K     P L +++  + +SV
Sbjct: 185 LRDPWNWLDFSVITLAYVGTAI-DLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSV 243

Query: 698 GALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECVCKIALDCNLPRWHMH----------- 745
             L ++T++    + +FA+VG+QLF G    +CV           +  H           
Sbjct: 244 KKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRG 303

Query: 746 -----------------------------DF----FHSF----LIVFRILCGEWIETMWD 768
                                        DF    F SF    L +FR++  +  E ++ 
Sbjct: 304 TSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQ 363

Query: 769 CMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDE 815
                   + +  F++V+ +G+  ++NL LA++  ++   + A +DE
Sbjct: 364 QTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDE 410



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 79/373 (21%), Positives = 150/373 (40%), Gaps = 70/373 (18%)

Query: 500  PAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQK-----CPPWWYKCAHK 554
            PA G D   S + S  +   P +       ++D +EE ++   +     CP         
Sbjct: 1074 PAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCP--------- 1124

Query: 555  VLIWNCC------APW---LKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEH 605
                 CC      +PW    + +   + IV   + +  I   I+L++  +A E Y + + 
Sbjct: 1125 -----CCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179

Query: 606  --FDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGL---- 659
                 +L   + VFT IF  EM+LK +A    +YF   W   D +IV +SL+ L      
Sbjct: 1180 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239

Query: 660  -ANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 718
             + V  +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G
Sbjct: 1240 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299

Query: 719  MQLFGKSYKECV--------------------CKIALDCNLPRW-----HMHDFFHSFLI 753
            + LF   +  C+                    CKI        W     +  +    +L 
Sbjct: 1300 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLA 1359

Query: 754  VFRILCGE-WIETMW---DCMEVAGQ------AMCLTVFLMVMVIGNLVVLNLFLALLLS 803
            + ++   + W++ M+   D  EV  Q            F++ ++ G    LNLF+ +++ 
Sbjct: 1360 LLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIID 1419

Query: 804  SFSADSLAASDED 816
            +F+        +D
Sbjct: 1420 NFNQQKKKLGGQD 1432



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 12/172 (6%)

Query: 137 IMITILTNCVFMTMSD---PPPWSKNVEY---TFTGIYTFESLIKILARGFCVDDFTFLR 190
           I + I+ N +FM M      P +   ++     FT  +T E + KI+A     D + + +
Sbjct: 671 ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIA----FDPYYYFQ 726

Query: 191 DPWNWLDFSVIMMAYLTEFV-DLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKK 249
             WN  D  ++ ++ L   V   G++S LR+FR+LR  K     P L T++  +  SV  
Sbjct: 727 KKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGA 786

Query: 250 LSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWY 301
           L ++ I+    + VFALVG QL   N R        P  D    W+ +D ++
Sbjct: 787 LGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDW-PRWHMHDFFH 837



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 46/195 (23%), Positives = 89/195 (45%), Gaps = 29/195 (14%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFT 1397
            P N I+     +     F + I + I +N V M          + D+   I  +F +I+T
Sbjct: 115  PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMT---------RTDLPEKIEYVFTVIYT 165

Query: 1398 GECVLKMLA----LRQY-YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRL 1452
             E ++K+LA    L ++ Y    WN  DF V+ L+ VG A+ DL             +R 
Sbjct: 166  FEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAI-DL--------RGISGLRT 216

Query: 1453 ARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF------AY 1506
             R+ R L+ +    G++ ++ AL+ S+  L ++ +L    + ++++ G+  F        
Sbjct: 217  FRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKC 276

Query: 1507 VKKESGIDDMFNFET 1521
            VK +  +++  N+ +
Sbjct: 277  VKNDMAVNETTNYSS 291



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 20/85 (23%), Positives = 44/85 (51%), Gaps = 1/85 (1%)

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
           F  +FL +FR++  ++ EN++           +I F+ ++ LG+  ++NL +A++  +++
Sbjct: 835 FFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS 894

Query: 452 EQNEATLAEDKEKEEEFQQMLEKFK 476
             N  T  ED  +    Q  L + +
Sbjct: 895 ADN-LTAPEDDGEVNNLQVALARIQ 918



 Score = 35.4 bits (80), Expect = 0.52
 Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAA---------GKTYM-IFFVVIIFLGSFY 437
            ++D  +  +LAL ++ T   W ++    + +             YM ++FV+ I  G F+
Sbjct: 1349 NFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFF 1408

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1409 TLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1448


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1033 bits (2672), Expect = 0.0
 Identities = 551/853 (64%), Positives = 633/853 (74%), Gaps = 69/853 (8%)

Query: 793  VLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKA----FLLGLLHGKI 848
            VLNLFLALLLSSFSAD+L A DED EMNNLQ+A+ RI+ G+ F K     F  GLL  + 
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 849  LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLE 908
              P   + + G+      A       PE EK  P  ++ + +       G    P     
Sbjct: 691  QKPA-ALAAQGQLPSC-IATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP--- 745

Query: 909  LDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPP--QPLYDGNSSVCS 966
                         + VPIA  ESD +   E+E ++    E+S K    QP+  G      
Sbjct: 746  -------------VCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG------ 786

Query: 967  TADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFK 1026
                  PE  P+ +           E    A    W   +    Q  G         C +
Sbjct: 787  ------PEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPG---------CGE 831

Query: 1027 IVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVA 1086
                                  AFEDIY+E+R+ I+ +LEYADK+FTY+F++EMLLKWVA
Sbjct: 832  ----------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVA 869

Query: 1087 YGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGM 1146
            YGFK YFTNAWCWLDFLIVDVS++SLVAN LG++E+GPIKSLRTLRALRPLRALSRFEGM
Sbjct: 870  YGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGM 929

Query: 1147 RVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSER-FDISEVNN 1205
            RVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T  +   + + VNN
Sbjct: 930  RVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNN 989

Query: 1206 KSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQY 1265
            KS+CESL  TG++ W  VKVN+DNVG GYL+LLQVATFKGWMDIMYAAVDSR  EEQPQ+
Sbjct: 990  KSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049

Query: 1266 EVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKK 1325
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG+DIFMTEEQKKYYNAMKK
Sbjct: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109

Query: 1326 LGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDIL 1385
            LGSKKPQKPIPRP NK QG ++D+VTKQAFD+TIM LICLNMVTMMVETD+QS  K++IL
Sbjct: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169

Query: 1386 YNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPT 1445
              IN++F+ IFTGEC++K+ ALR YYFT  WNIFDFVVVILSIVG  LSD+IQKYF SPT
Sbjct: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229

Query: 1446 LFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
            LFRVIRLARIGR+LRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM+NFA
Sbjct: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289

Query: 1506 YVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVK 1565
            YVK E+GIDDMFNF+TF NS++CLF+ITTSAGWDGLL+PILN+GPP CDP L N   S +
Sbjct: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348

Query: 1566 GDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWE 1625
            GDCG+P++GI FF +YIIISFLIVVNMYIAIILENF+VATEES+EPL EDDF+MFYE WE
Sbjct: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408

Query: 1626 KFDPDATQFIAYS 1638
            KFDP+ATQFI YS
Sbjct: 1409 KFDPEATQFIEYS 1421



 Score =  602 bits (1551), Expect = e-171
 Identities = 306/478 (64%), Positives = 362/478 (75%), Gaps = 38/478 (7%)

Query: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
           L+P G    R FTRESLAAIE+R  E++AR    LQ +++   EE   +P+ DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 65  PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
           P +YG+PP E+IG PLEDLDP+YS +KTFIVLNKGK IFRFSAT ALY+LSPF  +RR A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
           +K+L+H+LF+M IM TILTNCVFM   DPPPW+K VEYTFT IYTFESL+KILARGFC+ 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            FTFLRDPWNWLDFSVI+MAY TEFVDLGN+SALRTFRVLRALKTI+VI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
           QSVKKL+DVM+LTVFCLSVFAL+GLQLFMGNLR KCVR     N TN +  ++       
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGL----- 299

Query: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
                              W S            D Y+SD  N+    G++D LLCGNSS
Sbjct: 300 ------------------VWES-----------LDLYLSDPENYLLKNGTSDVLLCGNSS 330

Query: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
           DAG CPEGY C+K G NP++GYTS+D+F+WAFLALFRLMTQD WE L+Q TLR+AGK YM
Sbjct: 331 DAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM 390

Query: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEEL 482
           IFF+++IFLGSFYL+NLILAVVAMAY EQN+AT+AE +EKE+ FQ+ +E  KK  E L
Sbjct: 391 IFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEAL 448



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/345 (24%), Positives = 156/345 (45%), Gaps = 61/345 (17%)

Query: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079
            +RRA  KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1080 MLLKWVAYGFKVY-FT---NAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135
             L+K +A GF ++ FT   + W WLDF ++      ++A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCINTTT 1194
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   + C+   T
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1195 SERFDISEVNNKSECESLMHTGQVRWLNVKVNY--------------------------- 1227
            +    ++  N   E + L+      +L+   NY                           
Sbjct: 286  A----LNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRC 341

Query: 1228 ----DNVGLGYLSLLQVA-TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFG 1282
                +N   GY S    A  F     +M      R  ++  +    +YM ++F++ I  G
Sbjct: 342  LKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLG 400

Query: 1283 SFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEE-QKKYYNAMKKL 1326
            SF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 401  SFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 88.6 bits (218), Expect = 5e-17
 Identities = 72/272 (26%), Positives = 126/272 (46%), Gaps = 36/272 (13%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622
            P  K++  I  IV     D+ I   I LN + M +E    +    N+L   NL+F  IFT
Sbjct: 1122 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFT 1181

Query: 623  AEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANV--------QGLSVLRSFRLL 674
             E ++KL A+  Y YF   WNIFD ++V LS+V   L+++            V+R  R+ 
Sbjct: 1182 GECIVKLAALRHY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIG 1240

Query: 675  RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIA 734
            R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F     E      
Sbjct: 1241 RILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA----G 1296

Query: 735  LDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAGQAMC---------------- 778
            +D     ++   F +S L +F+I      + +   +   G   C                
Sbjct: 1297 ID---DMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGS 1353

Query: 779  ----LTVFLMVMVIGNLVVLNLFLALLLSSFS 806
                +  F   ++I  L+V+N+++A++L +FS
Sbjct: 1354 PAVGILFFTTYIIISFLIVVNMYIAIILENFS 1385



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 34/117 (29%), Positives = 67/117 (57%), Gaps = 10/117 (8%)

Query: 164 FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISA 217
           FT ++  E L+K +A GF      +  + W WLDF ++      ++A    F ++G I +
Sbjct: 855 FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 218 LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
           LRT R LR L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 911 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 967



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 39/247 (15%)

Query: 609  VLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVEL-----GLANVQ 663
            +L   + +FT +F  EM+LK +A    +YF   W   D +IV +SLV L     G A + 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 664  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 723
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 724  KSYKECVCKIALDCNL------------------------PRWHMHDFFHSFLIVFRILC 759
              +  C+ +   D  L                         + +  +    +L + ++  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 760  GE-WIETMWDCMEVAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADS 809
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086

Query: 810  LAASDED 816
                 +D
Sbjct: 1087 KKLGGQD 1093



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 46/167 (27%), Positives = 84/167 (50%), Gaps = 22/167 (13%)

Query: 574 IVMDPFVDLGITICIVLNTLFMAM-EHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA- 631
           I++    ++ I   I+ N +FMA  +  P T++ +         FT I+T E ++K++A 
Sbjct: 127 ILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE-------YTFTAIYTFESLVKILAR 179

Query: 632 ---MDPYEYFQQGWNIFD-SIIV---TLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWP 684
              +  + + +  WN  D S+I+   T   V+LG      +S LR+FR+LR  K      
Sbjct: 180 GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-----NVSALRTFRVLRALKTISVIS 234

Query: 685 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
            L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 235 GLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAG---------KTYM-IFFVVIIFLGSFY 437
            ++D     +LAL ++ T   W ++    + + G           YM I+FV+ I  GSF+
Sbjct: 1010 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFF 1069

Query: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 1070 TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  442 bits (1136), Expect = e-123
 Identities = 320/1130 (28%), Positives = 553/1130 (48%), Gaps = 125/1130 (11%)

Query: 564  WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
            W+ F   +  IV   +   GI + I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 624  EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
            EM+LKL+A  P  Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAL-----DCN 738
            P L   + ++  ++  +     +L + +FIF+++GM LFG       CK +L     D  
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDTGDTV 951

Query: 739  LPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLF 797
              R +      + + VF+IL  E W   +++ M        L  F+ +M  GN V+ NL 
Sbjct: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL-YFVALMTFGNYVLFNLL 1010

Query: 798  LALLLSSFSADSLA-ASDEDGEMNNLQIA--------IGRIKLGIGFAKAFLLGLLHGK- 847
            +A+L+  F A+  A  SD D +  ++           +   +L +        G L G+ 
Sbjct: 1011 VAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070

Query: 848  ILSPKDIMLSLGEADGAGEAGEAGETAPE--DEKK------EPPEEDLKKDNHILNHMGL 899
             LSP  IM +        ++    + AP   D ++      +PP  D K    + +    
Sbjct: 1071 SLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCA 1130

Query: 900  ADGPP---SSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQP 956
              GP    SS      +    P L  +      ES L    +  TD   E ED +  P P
Sbjct: 1131 PWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTD--DEAEDGRAAPGP 1188

Query: 957  LY---------------------------DGNSSVCSTADYKPPEEDPEEQAEENPEGE- 988
                                         DG      +  +   +   E+ AE + + E 
Sbjct: 1189 RATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSED 1248

Query: 989  -------------QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFET 1035
                         +P+ C +    + W  LY+   Q R       R +C K++ H  F+ 
Sbjct: 1249 SCCLRLHKVLEPYKPQWCRSR---EAW-ALYLFSPQNR------FRVSCQKVITHKMFDH 1298

Query: 1036 FIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGF----KV 1091
             ++  I L+   +A E   I+     R  L  ++ +FT IF+ EM++K VA G       
Sbjct: 1299 VVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHA 1358

Query: 1092 YFTNAWCWLDFLIVDVSIISLV---ANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRV 1148
            Y  ++W  LD L+V VS++ +V   A+  G   LG ++ LR LR LRPLR +SR  G+++
Sbjct: 1359 YLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL 1418

Query: 1149 VVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSE 1208
            VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYYC      E  D   ++ K++
Sbjct: 1419 VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC------EGPDTRNISTKAQ 1472

Query: 1209 CESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVN 1268
            C +       RW+  K N+DN+G   +SL  +++  GW++IMY  +D+   ++QP    N
Sbjct: 1473 CRA----AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528

Query: 1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
             +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++    EE  K    +++   
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE--KRLRRLERRRR 1586

Query: 1329 KKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNI 1388
            K  ++P     +  +  ++ L T    D+ I  +IC+N++TM +E  NQ +   + L   
Sbjct: 1587 KAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYC 1646

Query: 1389 NMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLALSDLIQKYF--VSPT 1445
            N +F I+F  E  LK++A   + +F   WN  D  +V+LS++G+ L ++       ++PT
Sbjct: 1647 NYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPT 1706

Query: 1446 LFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
            + R++R+ RI RVL+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G+  F 
Sbjct: 1707 IIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFG 1766

Query: 1506 YVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENP 1560
             ++        G+     F  FG + + LF ++T   W+G++   L     +C    ++ 
Sbjct: 1767 RLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR----ECSREDKHC 1822

Query: 1561 GTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSE 1610
             + +      P++   +F ++++++  ++VN+ +A+++++   + +E+ E
Sbjct: 1823 LSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE 1866



 Score =  116 bits (291), Expect = 2e-25
 Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 43/390 (11%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSK------NV 160
           A    + L   +  R   ++++ +  F    M+ I+ NCV + M  P    +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 161 EYTFTGI----YTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
              F       +  E +IK++A G       +L D WN LDF +++   +   +D  N+S
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 275 NLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN-SHASWATN 333
            LR +C        + N T+     +Y   T  G E  +   S   N     SH      
Sbjct: 255 LLRNRCFLDSAFVRNNNLTFLR--PYY--QTEEGEENPFICSSRRDNGMQKCSHIPGRRE 310

Query: 334 ----DTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTG-RNPNYGYTS 388
                T  W+AY   +     +  + +A +  N        + Y   ++G  NP+ G  +
Sbjct: 311 LRMPCTLGWEAYTQPQAE--GVGAARNACINWN--------QYYNVCRSGDSNPHNGAIN 360

Query: 389 YDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAM 448
           +D   +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A 
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 449 AYAEQNEATLAEDKEKEEEFQQMLEKFKKH 478
            ++E           K+ E Q M E+  +H
Sbjct: 421 QFSE----------TKQRESQLMREQRARH 440



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/273 (27%), Positives = 131/273 (47%), Gaps = 28/273 (10%)

Query: 571  IHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLI 630
            IH +    ++DL IT  I +N + M+MEHY   +  D  L   N VFT +F  E  LKL+
Sbjct: 1604 IHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLV 1663

Query: 631  AMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLA 680
            A     +F+  WN  D  IV LSL+ + L  ++           + ++R  R+ RV KL 
Sbjct: 1664 AFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLL 1723

Query: 681  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLP 740
            K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C     C   
Sbjct: 1724 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGL 1779

Query: 741  RWH--MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ----------AMCLTVFLMVMV 787
              H    +F  +FL +FR+  G+ W   M D +    +          A+    F+  ++
Sbjct: 1780 SRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVL 1839

Query: 788  IGNLVVLNLFLALLLSSFSADSLAASDEDGEMN 820
            +   V++N+ +A+L+     +S   + ED E++
Sbjct: 1840 VAQFVLVNVVVAVLMKHLE-ESNKEAREDAELD 1871



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 78/250 (31%), Positives = 114/250 (45%), Gaps = 33/250 (13%)

Query: 945  SEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPC 1004
            + PE    P +    G+    S ++    E   E  A+E      P    T         
Sbjct: 28   ASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYPALAAT--------- 78

Query: 1005 LYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRRV 1060
            ++  + Q    + W LR  C     + WFE   + +I+L+   L      ED+     R 
Sbjct: 79   VFFCLGQTTRPRSWCLRLVC-----NPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133

Query: 1061 IRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVANWL 1117
               ILE  D      F +EM++K VA   +G K Y  + W  LDF IV       VA  +
Sbjct: 134  --NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMM 184

Query: 1118 GYSELG---PIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174
             YS  G    + ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF
Sbjct: 185  EYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIF 244

Query: 1175 SIMGVNLFAG 1184
             I+GV L+AG
Sbjct: 245  GIVGVQLWAG 254



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 53/329 (16%)

Query: 527  DSGISDAMEELEEAHQKC-----------PPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            DS   DA E  +++   C            P W +      ++   +P  +F+     ++
Sbjct: 1233 DSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRVSCQKVI 1291

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPM----TEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
                 D  + + I LN + +A+E   +    TE     L+V N +FT IF AEM++K++A
Sbjct: 1292 THKMFDHVVLVFIFLNCVTIALERPDIDPGSTERV--FLSVSNYIFTAIFVAEMMVKVVA 1349

Query: 632  MD----PYEYFQQGWNIFDSIIVTLSLVEL-------GLANVQG-LSVLRSFRLLRVFKL 679
            +      + Y Q  WN+ D ++V +SLV++       G A + G L VLR  R LR  ++
Sbjct: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409

Query: 680  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------K 727
                P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y            
Sbjct: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469

Query: 728  ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGE--WIETMWDCMEVAG---------QA 776
            +  C+ A    + R +  D     L+   +L  +  W+  M+D ++  G           
Sbjct: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529

Query: 777  MCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 55/182 (30%), Positives = 95/182 (52%), Gaps = 17/182 (9%)

Query: 110  ALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP---PPWSKNV-----E 161
            ALYL SP +  R    KV+ H +F   +++ I  NCV + +  P   P  ++ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------L 212
            Y FT I+  E ++K++A G    +  +L+  WN LD  +++++ +   V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
            G +  LR  R LR L+ I+  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MG 274
             G
Sbjct: 1453 KG 1454



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 99/449 (22%), Positives = 180/449 (40%), Gaps = 71/449 (15%)

Query: 859  GEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNP 918
            G   G G  G     +P+  +K P         H++   GL   P       HL+ ++ P
Sbjct: 638  GGPPGTGGHGPLSLNSPDPYEKIP---------HVVGEHGLGQAP------GHLSGLSVP 682

Query: 919  YLTIQVPIASEESDLEM------PTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKP 972
                  P  +   +L+         E+     S  E      + +Y+    V    D   
Sbjct: 683  CPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDV-RHGDRWD 741

Query: 973  PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNW 1032
            P   P       P    P+    +      P          G+ W T      +IV+  +
Sbjct: 742  PTRPPRATDTPGPGPGSPQRRAQQRAAPGEP-------GWMGRLWVTFSGKLRRIVDSKY 794

Query: 1033 FETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVY 1092
            F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK +A G   Y
Sbjct: 795  FSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGY 852

Query: 1093 FTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNA 1152
              N +   D +IV +S+  +V    G ++ G +  LRT R LR L+ +     +R  +  
Sbjct: 853  IRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFLPALRRQLVV 907

Query: 1153 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESL 1212
            L+  + ++     + ++F  IFSI+G++LF  KF   + T T +                
Sbjct: 908  LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF--SLKTDTGDT--------------- 950

Query: 1213 MHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMY 1272
                    +  + N+D++    +++ Q+ T + W  ++Y  + S           + +  
Sbjct: 951  --------VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----------TSSWAA 992

Query: 1273 LYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
            LYFV  + FG++   NL + ++++ F  +
Sbjct: 993  LYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 75/288 (26%), Positives = 130/288 (45%), Gaps = 41/288 (14%)

Query: 1344 GMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLK 1403
            G +  +V  + F   IM+ I +N ++M VE   Q +   + L   N++F  +F  E +LK
Sbjct: 784  GKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK 843

Query: 1404 MLALRQY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVL 1459
            +LA     Y    +NIFD ++V++S   IVG A   L            V+R  R+ RVL
Sbjct: 844  LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVL 892

Query: 1460 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA---YVKKESG--ID 1514
            +L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K ++G  + 
Sbjct: 893  KLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVP 952

Query: 1515 DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIG 1574
            D  NF++   +I+ +F+I T   W+ +L                       G     S  
Sbjct: 953  DRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWA 991

Query: 1575 ICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYE 1622
              +F + +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 992  ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 36/124 (29%), Positives = 69/124 (55%), Gaps = 13/124 (10%)

Query: 1205 NKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQ 1264
            N ++  ++  +G     N  +N+DN+G  ++++ QV T +GW+DIMY  +D+        
Sbjct: 339  NWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH------- 391

Query: 1265 YEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMK 1324
               + Y ++YF++ II GSFF +NL + VI   F++ K++   +   M E++ ++ +   
Sbjct: 392  ---SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDS 445

Query: 1325 KLGS 1328
             L S
Sbjct: 446  TLAS 449



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 15/166 (9%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+++  L++M   V LG         +F   E         N+L   +      
Sbjct: 98  CNPW--FEHVSMLVIMLNCVTLG---------MFRPCEDVECGSERCNILEAFDAFIFAF 146

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVELGL-ANVQGLSVLRSFRLLRV 676
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L  +   LS +R+ R+LR 
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206

Query: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
            +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 44/148 (29%), Positives = 81/148 (54%), Gaps = 13/148 (8%)

Query: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
           FS  IM+ IL N + M +     P   +  +E +   FT ++  E L+K+LA G      
Sbjct: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850

Query: 187 TFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            ++R+P+N  D  +I++  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 851 GYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLV 909

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLF 272
           +++  ++    L +  + +F+++G+ LF
Sbjct: 910 KTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 21/173 (12%)

Query: 117  FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-PPPWS-----KNVEYTFTGIYTF 170
            +S  RR    +       +FI   I  N + M+M     P S     K   Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 171  ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA-----------LR 219
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 220  TFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 15/165 (9%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMV----ETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404
            LV    F+   M++I LN VT+ +    E       + +IL   +      F  E V+KM
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1405 LAL----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLR 1460
            +AL    ++ Y    WN  DF +V+  ++  +L      + VS      IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG----HNVS---LSAIRTVRVLRPLR 208

Query: 1461 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 35/177 (19%), Positives = 73/177 (41%), Gaps = 17/177 (9%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
            ++D+  WA + +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 448  MAYAEQNEATLAEDKEKEE--EFQQMLEKFKKHQEELEKAKAAQALEGGEADG------- 498
              +  + +A  ++  E +    F++   K ++ Q    K  +      G  +G       
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 499  -------DPAHGKDCNGSLDTSQGEKGAPR-QSSSGDSGISDAMEELEEAHQKCPPW 547
                    P      +  LD +     + R  SSSGD  + D           C PW
Sbjct: 1076 LIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 27/134 (20%)

Query: 381  NPNYGYTSYDTFS---WAFLALFRLMTQDYWENLFQLTLRAAGK------TYM-----IF 426
            NP  G + + TFS    AFL LFR+ T D W  + + TLR   +      +Y+     ++
Sbjct: 1774 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1833

Query: 427  FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486
            FV  + +  F L+N+++AV+ M + E++     ED E + E             ELE A+
Sbjct: 1834 FVTFVLVAQFVLVNVVVAVL-MKHLEESNKEAREDAELDAEI------------ELEMAQ 1880

Query: 487  AAQALEGGEADGDP 500
               +    +AD  P
Sbjct: 1881 GPGSARRVDADRPP 1894



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 32/151 (21%), Positives = 67/151 (44%), Gaps = 24/151 (15%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G FY+ EG +      N S    C    Y  ++   N       +D    A ++LF L 
Sbjct: 1453 KGKFYYCEGPDTR----NISTKAQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLS 1501

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W N+    L A G             +++F+  + + SF+++N+ + VV   + + 
Sbjct: 1502 SKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKC 1561

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEK 484
             +   AE+  + EE  + L + ++ + + ++
Sbjct: 1562 RQHQEAEEARRREE--KRLRRLERRRRKAQR 1590


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score =  437 bits (1125), Expect = e-122
 Identities = 320/1135 (28%), Positives = 554/1135 (48%), Gaps = 129/1135 (11%)

Query: 564  WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
            W+ F   +  IV   +   GI + I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 624  EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
            EM+LKL+A  P  Y +  +NIFD IIV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAL-----DCN 738
            P L   + ++  ++  +     +L + +FIF+++GM LFG       CK +L     D  
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDTGDTV 951

Query: 739  LPRWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLF 797
              R +      + + VF+IL  E W   +++ M        L  F+ +M  GN V+ NL 
Sbjct: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL-YFVALMTFGNYVLFNLL 1010

Query: 798  LALLLSSFSADSLA-ASDEDGEMNNLQIA--------IGRIKLGIGFAKAFLLGLLHGK- 847
            +A+L+  F A+  A  SD D +  ++           +   +L +        G L G+ 
Sbjct: 1011 VAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRG 1070

Query: 848  ILSPKDIMLSLGEADGAGEAGEAGETAPE--DEKK------EPPEEDLKKDNHILNHMGL 899
             LSP  IM +        ++    + AP   D ++      +PP  D K    + +    
Sbjct: 1071 SLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCA 1130

Query: 900  ADGPP---SSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQP 956
              GP    SS      +    P L  +      ES L    +  TD   E ED +  P P
Sbjct: 1131 PWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTD--DEAEDGRAAPGP 1188

Query: 957  LY---------------------------DGNSSVCSTADYKPPEEDPEEQAEENPEGE- 988
                                         DG      +  +   +   E+ AE + + E 
Sbjct: 1189 RATPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSED 1248

Query: 989  -------------QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFET 1035
                         +P+ C +    + W  LY+   Q R       R +C K++ H  F+ 
Sbjct: 1249 SCCLRLHKVLEPYKPQWCRSR---EAW-ALYLFSPQNR------FRVSCQKVITHKMFDH 1298

Query: 1036 FIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGF----KV 1091
             ++  I L+   +A E   I+     R  L  ++ +FT IF+ EM++K VA G       
Sbjct: 1299 VVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHA 1358

Query: 1092 YFTNAWCWLDFLIVDVSIISLV---ANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRV 1148
            Y  ++W  LD L+V VS++ +V   A+  G   LG ++ LR LR LRPLR +SR  G+++
Sbjct: 1359 YLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKL 1418

Query: 1149 VVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSE 1208
            VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYYC      E  D   ++ K++
Sbjct: 1419 VVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC------EGPDTRNISTKAQ 1472

Query: 1209 CESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVN 1268
            C +       RW+  K N+DN+G   +SL  +++  GW++IMY  +D+   ++QP    N
Sbjct: 1473 CRA----AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528

Query: 1269 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
             +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++     E+K+     ++  S
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA-RRREEKRLRRLERRRRS 1587

Query: 1329 KKP-----QKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVD 1383
              P     ++P     +  +  ++ L T    D+ I  +IC+N++TM +E  NQ +   +
Sbjct: 1588 TFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDE 1647

Query: 1384 ILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLALSDLIQKYF- 1441
             L   N +F I+F  E  LK++A   + +F   WN  D  +V+LS++G+ L ++      
Sbjct: 1648 ALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAAL 1707

Query: 1442 -VSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFG 1500
             ++PT+ R++R+ RI RVL+L++ A G+R LL  ++ +LP + N+GLL  L+ FIY+  G
Sbjct: 1708 PINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALG 1767

Query: 1501 MSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDP 1555
            +  F  ++        G+     F  FG + + LF ++T   W+G++   L     +C  
Sbjct: 1768 VELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR----ECSR 1823

Query: 1556 NLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSE 1610
              ++  + +      P++   +F ++++++  ++VN+ +A+++++   + +E+ E
Sbjct: 1824 EDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEARE 1872



 Score =  116 bits (291), Expect = 2e-25
 Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 43/390 (11%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSK------NV 160
           A    + L   +  R   ++++ +  F    M+ I+ NCV + M  P    +      N+
Sbjct: 76  AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135

Query: 161 EYTFTGI----YTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
              F       +  E +IK++A G       +L D WN LDF +++   +   +D  N+S
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS 194

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 195 LSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254

Query: 275 NLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWN-SHASWATN 333
            LR +C        + N T+     +Y   T  G E  +   S   N     SH      
Sbjct: 255 LLRNRCFLDSAFVRNNNLTFLR--PYY--QTEEGEENPFICSSRRDNGMQKCSHIPGRRE 310

Query: 334 ----DTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTG-RNPNYGYTS 388
                T  W+AY   +     +  + +A +  N        + Y   ++G  NP+ G  +
Sbjct: 311 LRMPCTLGWEAYTQPQAE--GVGAARNACINWN--------QYYNVCRSGDSNPHNGAIN 360

Query: 389 YDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAM 448
           +D   +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A 
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT 420

Query: 449 AYAEQNEATLAEDKEKEEEFQQMLEKFKKH 478
            ++E           K+ E Q M E+  +H
Sbjct: 421 QFSE----------TKQRESQLMREQRARH 440



 Score =  106 bits (265), Expect = 2e-22
 Identities = 76/273 (27%), Positives = 131/273 (47%), Gaps = 28/273 (10%)

Query: 571  IHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLI 630
            IH +    ++DL IT  I +N + M+MEHY   +  D  L   N VFT +F  E  LKL+
Sbjct: 1610 IHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLV 1669

Query: 631  AMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLA 680
            A     +F+  WN  D  IV LSL+ + L  ++           + ++R  R+ RV KL 
Sbjct: 1670 AFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLL 1729

Query: 681  KSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLP 740
            K    +  L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C     C   
Sbjct: 1730 KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGL 1785

Query: 741  RWH--MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ----------AMCLTVFLMVMV 787
              H    +F  +FL +FR+  G+ W   M D +    +          A+    F+  ++
Sbjct: 1786 SRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVL 1845

Query: 788  IGNLVVLNLFLALLLSSFSADSLAASDEDGEMN 820
            +   V++N+ +A+L+     +S   + ED E++
Sbjct: 1846 VAQFVLVNVVVAVLMKHLE-ESNKEAREDAELD 1877



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 78/250 (31%), Positives = 114/250 (45%), Gaps = 33/250 (13%)

Query: 945  SEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPC 1004
            + PE    P +    G+    S ++    E   E  A+E      P    T         
Sbjct: 28   ASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRVPYPALAAT--------- 78

Query: 1005 LYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRRV 1060
            ++  + Q    + W LR  C     + WFE   + +I+L+   L      ED+     R 
Sbjct: 79   VFFCLGQTTRPRSWCLRLVC-----NPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC 133

Query: 1061 IRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVANWL 1117
               ILE  D      F +EM++K VA   +G K Y  + W  LDF IV       VA  +
Sbjct: 134  --NILEAFDAFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIV-------VAGMM 184

Query: 1118 GYSELG---PIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIF 1174
             YS  G    + ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF
Sbjct: 185  EYSLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIF 244

Query: 1175 SIMGVNLFAG 1184
             I+GV L+AG
Sbjct: 245  GIVGVQLWAG 254



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 82/329 (24%), Positives = 150/329 (45%), Gaps = 53/329 (16%)

Query: 527  DSGISDAMEELEEAHQKC-----------PPWWYKCAHKVLIWNCCAPWLKFKNIIHLIV 575
            DS   DA E  +++   C            P W +      ++   +P  +F+     ++
Sbjct: 1233 DSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALY-LFSPQNRFRVSCQKVI 1291

Query: 576  MDPFVDLGITICIVLNTLFMAMEHYPM----TEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
                 D  + + I LN + +A+E   +    TE     L+V N +FT IF AEM++K++A
Sbjct: 1292 THKMFDHVVLVFIFLNCVTIALERPDIDPGSTERV--FLSVSNYIFTAIFVAEMMVKVVA 1349

Query: 632  MD----PYEYFQQGWNIFDSIIVTLSLVEL-------GLANVQG-LSVLRSFRLLRVFKL 679
            +      + Y Q  WN+ D ++V +SLV++       G A + G L VLR  R LR  ++
Sbjct: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409

Query: 680  AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------K 727
                P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y            
Sbjct: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469

Query: 728  ECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGE--WIETMWDCMEVAG---------QA 776
            +  C+ A    + R +  D     L+   +L  +  W+  M+D ++  G           
Sbjct: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529

Query: 777  MCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 55/182 (30%), Positives = 95/182 (52%), Gaps = 17/182 (9%)

Query: 110  ALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP---PPWSKNV-----E 161
            ALYL SP +  R    KV+ H +F   +++ I  NCV + +  P   P  ++ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 162  YTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------L 212
            Y FT I+  E ++K++A G    +  +L+  WN LD  +++++ +   V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 213  GNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
            G +  LR  R LR L+ I+  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 273  MG 274
             G
Sbjct: 1453 KG 1454



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 99/449 (22%), Positives = 180/449 (40%), Gaps = 71/449 (15%)

Query: 859  GEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNP 918
            G   G G  G     +P+  +K P         H++   GL   P       HL+ ++ P
Sbjct: 638  GGPPGTGGHGPLSLNSPDPYEKIP---------HVVGEHGLGQAP------GHLSGLSVP 682

Query: 919  YLTIQVPIASEESDLEM------PTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKP 972
                  P  +   +L+         E+     S  E      + +Y+    V    D   
Sbjct: 683  CPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDV-RHGDRWD 741

Query: 973  PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNW 1032
            P   P       P    P+    +      P          G+ W T      +IV+  +
Sbjct: 742  PTRPPRATDTPGPGPGSPQRRAQQRAAPGEP-------GWMGRLWVTFSGKLRRIVDSKY 794

Query: 1033 FETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVY 1092
            F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK +A G   Y
Sbjct: 795  FSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGY 852

Query: 1093 FTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNA 1152
              N +   D +IV +S+  +V    G ++ G +  LRT R LR L+ +     +R  +  
Sbjct: 853  IRNPYNIFDGIIVVISVWEIV----GQAD-GGLSVLRTFRLLRVLKLVRFLPALRRQLVV 907

Query: 1153 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESL 1212
            L+  + ++     + ++F  IFSI+G++LF  KF   + T T +                
Sbjct: 908  LVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF--SLKTDTGDT--------------- 950

Query: 1213 MHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMY 1272
                    +  + N+D++    +++ Q+ T + W  ++Y  + S           + +  
Sbjct: 951  --------VPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMAS----------TSSWAA 992

Query: 1273 LYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
            LYFV  + FG++   NL + ++++ F  +
Sbjct: 993  LYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 75/288 (26%), Positives = 130/288 (45%), Gaps = 41/288 (14%)

Query: 1344 GMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLK 1403
            G +  +V  + F   IM+ I +N ++M VE   Q +   + L   N++F  +F  E +LK
Sbjct: 784  GKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK 843

Query: 1404 MLALRQY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVL 1459
            +LA     Y    +NIFD ++V++S   IVG A   L            V+R  R+ RVL
Sbjct: 844  LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVL 892

Query: 1460 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA---YVKKESG--ID 1514
            +L+R    +R  L  L+ ++  +     LL L +FI+SI GM  F     +K ++G  + 
Sbjct: 893  KLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVP 952

Query: 1515 DMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIG 1574
            D  NF++   +I+ +F+I T   W+ +L                       G     S  
Sbjct: 953  DRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSSWA 991

Query: 1575 ICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYE 1622
              +F + +     ++ N+ +AI++E F    + +     ED   + +E
Sbjct: 992  ALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 36/124 (29%), Positives = 69/124 (55%), Gaps = 13/124 (10%)

Query: 1205 NKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQ 1264
            N ++  ++  +G     N  +N+DN+G  ++++ QV T +GW+DIMY  +D+        
Sbjct: 339  NWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH------- 391

Query: 1265 YEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMK 1324
               + Y ++YF++ II GSFF +NL + VI   F++ K++   +   M E++ ++ +   
Sbjct: 392  ---SFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDS 445

Query: 1325 KLGS 1328
             L S
Sbjct: 446  TLAS 449



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 46/166 (27%), Positives = 81/166 (48%), Gaps = 15/166 (9%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+++  L++M   V LG         +F   E         N+L   +      
Sbjct: 98  CNPW--FEHVSMLVIMLNCVTLG---------MFRPCEDVECGSERCNILEAFDAFIFAF 146

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVELGL-ANVQGLSVLRSFRLLRV 676
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L  +   LS +R+ R+LR 
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206

Query: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
            +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 65.1 bits (157), Expect = 6e-10
 Identities = 44/148 (29%), Positives = 81/148 (54%), Gaps = 13/148 (8%)

Query: 133 FSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILARGFCVDDF 186
           FS  IM+ IL N + M +     P   +  +E +   FT ++  E L+K+LA G      
Sbjct: 795 FSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACG----PL 850

Query: 187 TFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLKTIVGALI 244
            ++R+P+N  D  +I++  + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 851 GYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLV 909

Query: 245 QSVKKLSDVMILTVFCLSVFALVGLQLF 272
           +++  ++    L +  + +F+++G+ LF
Sbjct: 910 KTMDNVATFCTLLMLFIFIFSILGMHLF 937



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 41/173 (23%), Positives = 86/173 (49%), Gaps = 21/173 (12%)

Query: 117  FSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSD-PPPWS-----KNVEYTFTGIYTF 170
            +S  RR    +       +FI   I  N + M+M     P S     K   Y FT ++ F
Sbjct: 1603 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1662

Query: 171  ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA-----------LR 219
            E+ +K++A GF      F +D WN LD ++++++ +   ++   +SA           +R
Sbjct: 1663 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1718

Query: 220  TFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1719 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 51/165 (30%), Positives = 78/165 (47%), Gaps = 15/165 (9%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMV----ETDNQSQLKVDILYNINMIFIIIFTGECVLKM 1404
            LV    F+   M++I LN VT+ +    E       + +IL   +      F  E V+KM
Sbjct: 96   LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155

Query: 1405 LAL----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLR 1460
            +AL    ++ Y    WN  DF +V+  ++  +L      + VS      IR  R+ R LR
Sbjct: 156  VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDG----HNVS---LSAIRTVRVLRPLR 208

Query: 1461 LIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
             I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 209  AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 35/177 (19%), Positives = 73/177 (41%), Gaps = 17/177 (9%)

Query: 388  SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
            ++D+  WA + +F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 448  MAYAEQNEATLAEDKEKEE--EFQQMLEKFKKHQEELEKAKAAQALEGGEADG------- 498
              +  + +A  ++  E +    F++   K ++ Q    K  +      G  +G       
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSLSPP 1075

Query: 499  -------DPAHGKDCNGSLDTSQGEKGAPR-QSSSGDSGISDAMEELEEAHQKCPPW 547
                    P      +  LD +     + R  SSSGD  + D           C PW
Sbjct: 1076 LIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPW 1132



 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 39/134 (29%), Positives = 63/134 (47%), Gaps = 27/134 (20%)

Query: 381  NPNYGYTSYDTFS---WAFLALFRLMTQDYWENLFQLTLRAAGK------TYM-----IF 426
            NP  G + + TFS    AFL LFR+ T D W  + + TLR   +      +Y+     ++
Sbjct: 1780 NPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVY 1839

Query: 427  FVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAK 486
            FV  + +  F L+N+++AV+ M + E++     ED E + E             ELE A+
Sbjct: 1840 FVTFVLVAQFVLVNVVVAVL-MKHLEESNKEAREDAELDAEI------------ELEMAQ 1886

Query: 487  AAQALEGGEADGDP 500
               +    +AD  P
Sbjct: 1887 GPGSARRVDADRPP 1900



 Score = 41.6 bits (96), Expect = 0.007
 Identities = 31/134 (23%), Positives = 58/134 (43%), Gaps = 22/134 (16%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G FY+ EG +      N S    C    Y  ++   N       +D    A ++LF L 
Sbjct: 1453 KGKFYYCEGPDTR----NISTKAQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLS 1501

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W N+    L A G             +++F+  + + SF+++N+ + VV   + + 
Sbjct: 1502 SKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKC 1561

Query: 454  NEATLAEDKEKEEE 467
             +   AE+  + EE
Sbjct: 1562 RQHQEAEEARRREE 1575


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1419 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1472

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1473 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1531

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1591

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1592 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1651

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1652 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1771

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1772 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1818

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1819 HLEESNKEAKE 1829



 Score =  141 bits (355), Expect = 7e-33
 Identities = 85/257 (33%), Positives = 139/257 (54%), Gaps = 13/257 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLAASDE 815
           A+L+  F A+  A   E
Sbjct: 961 AILVEGFQAEGDANKSE 977



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1412 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1460

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1519

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1520 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1547

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1548 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1572

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1748

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1749 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1808

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1809 VNVVIAVLMKHLEESNKEAKEE 1830



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1296

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1477 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1525

Query: 1610 E 1610
            E
Sbjct: 1526 E 1526



 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 81/458 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
                + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 43/274 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMS----NFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENFNV---ATEESSEP 1611
             +     ++ N+ +AI++E F     A +  SEP
Sbjct: 947  LMTFGNYVLFNLLVAILVEGFQAEGDANKSESEP 980



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1726 LGVELF 1731



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1736 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1790

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1791 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1838



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 15/75 (20%), Positives = 43/75 (57%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAEDK 462
             +  + +A  +E +
Sbjct: 965 EGFQAEGDANKSESE 979


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1419 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1472

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1473 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1531

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1591

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1592 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1651

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1652 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1771

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1772 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1818

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1819 HLEESNKEAKE 1829



 Score =  141 bits (355), Expect = 7e-33
 Identities = 85/257 (33%), Positives = 139/257 (54%), Gaps = 13/257 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLAASDE 815
           A+L+  F A+  A   E
Sbjct: 961 AILVEGFQAEGDANKSE 977



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1412 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1460

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1519

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1520 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1547

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1548 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1572

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1748

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1749 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1808

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1809 VNVVIAVLMKHLEESNKEAKEE 1830



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1296

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1477 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1525

Query: 1610 E 1610
            E
Sbjct: 1526 E 1526



 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 81/458 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
                + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 43/274 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMS----NFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENFNV---ATEESSEP 1611
             +     ++ N+ +AI++E F     A +  SEP
Sbjct: 947  LMTFGNYVLFNLLVAILVEGFQAEGDANKSESEP 980



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1726 LGVELF 1731



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1736 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1790

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1791 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1838



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 15/75 (20%), Positives = 43/75 (57%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAEDK 462
             +  + +A  +E +
Sbjct: 965 EGFQAEGDANKSESE 979


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1441

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1442 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1554

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1614

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1615 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1674

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1675 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1794

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1795 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1841

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1842 HLEESNKEAKE 1852



 Score =  145 bits (366), Expect = 4e-34
 Identities = 86/269 (31%), Positives = 148/269 (55%), Gaps = 14/269 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLA-ASDEDGEMNNLQIAI 826
           A+L+  F A+ ++   D  G+++ +Q+ +
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1435 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1483

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1484 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1542

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1543 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1570

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1571 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1595

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1596 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1655

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1656 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1715

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1716 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1771

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1772 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1831

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1832 VNVVIAVLMKHLEESNKEAKEE 1853



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1319

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1500 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1548

Query: 1610 E 1610
            E
Sbjct: 1549 E 1549



 Score =  100 bits (249), Expect = 1e-20
 Identities = 103/459 (22%), Positives = 190/459 (41%), Gaps = 81/459 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1302
                + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1439

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1440 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 69/261 (26%), Positives = 118/261 (45%), Gaps = 40/261 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SNFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENF 1601
             +     ++ N+ +AI++E F
Sbjct: 947  LMTFGNYVLFNLLVAILVEGF 967



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1749 LGVELF 1754



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1759 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1813

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1814 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1861



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 16/74 (21%), Positives = 42/74 (56%), Gaps = 1/74 (1%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAED 461
             + +  E +  ED
Sbjct: 965 EGF-QAEEISKRED 977


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1419 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1472

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1473 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1531

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1591

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1592 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1651

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1652 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1771

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1772 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1818

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1819 HLEESNKEAKE 1829



 Score =  141 bits (355), Expect = 7e-33
 Identities = 85/257 (33%), Positives = 139/257 (54%), Gaps = 13/257 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLAASDE 815
           A+L+  F A+  A   E
Sbjct: 961 AILVEGFQAEGDANKSE 977



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1412 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1460

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1519

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1520 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1547

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1548 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1572

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1748

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1749 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1808

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1809 VNVVIAVLMKHLEESNKEAKEE 1830



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1296

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1477 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1525

Query: 1610 E 1610
            E
Sbjct: 1526 E 1526



 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 81/458 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
                + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 43/274 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMS----NFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENFNV---ATEESSEP 1611
             +     ++ N+ +AI++E F     A +  SEP
Sbjct: 947  LMTFGNYVLFNLLVAILVEGFQAEGDANKSESEP 980



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1726 LGVELF 1731



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1736 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1790

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1791 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1838



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 15/75 (20%), Positives = 43/75 (57%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAEDK 462
             +  + +A  +E +
Sbjct: 965 EGFQAEGDANKSESE 979


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1441

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1442 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1554

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1614

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1615 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1674

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1675 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1794

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1795 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1841

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1842 HLEESNKEAKE 1852



 Score =  145 bits (366), Expect = 4e-34
 Identities = 86/269 (31%), Positives = 148/269 (55%), Gaps = 14/269 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLA-ASDEDGEMNNLQIAI 826
           A+L+  F A+ ++   D  G+++ +Q+ +
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1435 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1483

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1484 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1542

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1543 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1570

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1571 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1595

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1596 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1655

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1656 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1715

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1716 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1771

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1772 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1831

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1832 VNVVIAVLMKHLEESNKEAKEE 1853



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1319

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1500 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1548

Query: 1610 E 1610
            E
Sbjct: 1549 E 1549



 Score =  100 bits (249), Expect = 1e-20
 Identities = 103/459 (22%), Positives = 190/459 (41%), Gaps = 81/459 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1302
                + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1439

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1440 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 69/261 (26%), Positives = 118/261 (45%), Gaps = 40/261 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SNFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENF 1601
             +     ++ N+ +AI++E F
Sbjct: 947  LMTFGNYVLFNLLVAILVEGF 967



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1633 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1688

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1689 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1748

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1749 LGVELF 1754



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1759 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1813

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1814 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1861



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 16/74 (21%), Positives = 42/74 (56%), Gaps = 1/74 (1%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAED 461
             + +  E +  ED
Sbjct: 965 EGF-QAEEISKRED 977


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score =  331 bits (849), Expect = 3e-90
 Identities = 195/611 (31%), Positives = 341/611 (55%), Gaps = 45/611 (7%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1419 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1472

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1473 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-RR 1531

Query: 1314 EEQKKYYNAMKKLGSKKPQ------KPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNM 1367
             E+K+     KK  SK+ Q      KP     ++ + +V+ L T    D+ I  +I LN+
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNV 1591

Query: 1368 VTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVIL 1426
            VTM +E   Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+L
Sbjct: 1592 VTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLL 1651

Query: 1427 SIVGLALSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFN 1484
            SI+G+ L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N
Sbjct: 1652 SIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711

Query: 1485 IGLLLFLVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWD 1539
            +GLL  L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWN 1771

Query: 1540 GLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILE 1599
            G++   L     DCD          +  C N  I   +F S+++ +  ++VN+ IA++++
Sbjct: 1772 GIMKDTLR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMK 1818

Query: 1600 NFNVATEESSE 1610
            +   + +E+ E
Sbjct: 1819 HLEESNKEAKE 1829



 Score =  141 bits (355), Expect = 7e-33
 Identities = 85/257 (33%), Positives = 139/257 (54%), Gaps = 13/257 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLAASDE 815
           A+L+  F A+  A   E
Sbjct: 961 AILVEGFQAEGDANKSE 977



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  121 bits (303), Expect = 7e-27
 Identities = 112/502 (22%), Positives = 208/502 (41%), Gaps = 114/502 (22%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1412 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1460

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV   + + 
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHK- 1519

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                     ++EEE ++  EK  +  E+  ++K                           
Sbjct: 1520 -----CRQHQEEEEARRREEKRLRRLEKKRRSK--------------------------- 1547

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHL 573
                                  E + A  +C P++             + + +F+ ++H 
Sbjct: 1548 ----------------------EKQMAEAQCKPYY-------------SDYSRFRLLVHH 1572

Query: 574  IVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMD 633
            +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A  
Sbjct: 1573 LCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFG 1632

Query: 634  PYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAKSW 683
               +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K  
Sbjct: 1633 FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMA 1692

Query: 684  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWH 743
              +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C     H
Sbjct: 1693 VGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLGRH 1748

Query: 744  --MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNLVV 793
                +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    V+
Sbjct: 1749 ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVL 1808

Query: 794  LNLFLALLLSSFSADSLAASDE 815
            +N+ +A+L+      +  A +E
Sbjct: 1809 VNVVIAVLMKHLEESNKEAKEE 1830



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1296

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1477 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1525

Query: 1610 E 1610
            E
Sbjct: 1526 E 1526



 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 81/458 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
                + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 43/274 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMS----NFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENFNV---ATEESSEP 1611
             +     ++ N+ +AI++E F     A +  SEP
Sbjct: 947  LMTFGNYVLFNLLVAILVEGFQAEGDANKSESEP 980



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1610 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1665

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1666 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1725

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1726 LGVELF 1731



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1736 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1790

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1791 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1838



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 15/75 (20%), Positives = 43/75 (57%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAEDK 462
             +  + +A  +E +
Sbjct: 965 EGFQAEGDANKSESE 979


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score =  331 bits (848), Expect = 5e-90
 Identities = 193/605 (31%), Positives = 338/605 (55%), Gaps = 40/605 (6%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1419 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1472

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1473 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRR 1532

Query: 1314 EEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE 1373
            EE  K    ++K   K   KP     ++ + +V+ L T    D+ I  +I LN+VTM +E
Sbjct: 1533 EE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1590

Query: 1374 TDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLA 1432
               Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+LSI+G+ 
Sbjct: 1591 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1650

Query: 1433 LSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1490
            L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N+GLL  
Sbjct: 1651 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1710

Query: 1491 LVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPI 1545
            L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+G++   
Sbjct: 1711 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1770

Query: 1546 LNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVAT 1605
            L     DCD          +  C N  I   +F S+++ +  ++VN+ IA+++++   + 
Sbjct: 1771 LR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1817

Query: 1606 EESSE 1610
            +E+ E
Sbjct: 1818 KEAKE 1822



 Score =  141 bits (355), Expect = 7e-33
 Identities = 85/257 (33%), Positives = 139/257 (54%), Gaps = 13/257 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLAASDE 815
           A+L+  F A+  A   E
Sbjct: 961 AILVEGFQAEGDANKSE 977



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  117 bits (292), Expect = 1e-25
 Identities = 112/504 (22%), Positives = 204/504 (40%), Gaps = 125/504 (24%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1412 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1460

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV       
Sbjct: 1461 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVV------ 1514

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                            +   K ++HQEE E  +  +                        
Sbjct: 1515 ----------------ENFHKCRQHQEEEEARRREEK----------------------- 1535

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQK--CPPWWYKCAHKVLIWNCCAPWLKFKNII 571
                                +  LE+  +K  C P++             + + +F+ ++
Sbjct: 1536 -------------------RLRRLEKKRRKAQCKPYY-------------SDYSRFRLLV 1563

Query: 572  HLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
            H +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A
Sbjct: 1564 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1623

Query: 632  MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAK 681
                 +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K
Sbjct: 1624 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1683

Query: 682  SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
                +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C    
Sbjct: 1684 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLG 1739

Query: 742  WH--MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNL 791
             H    +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    
Sbjct: 1740 RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1799

Query: 792  VVLNLFLALLLSSFSADSLAASDE 815
            V++N+ +A+L+      +  A +E
Sbjct: 1800 VLVNVVIAVLMKHLEESNKEAKEE 1823



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1296

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1297 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1356

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1357 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1416

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1417 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1476

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1477 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1525

Query: 1610 E 1610
            E
Sbjct: 1526 E 1526



 Score =  100 bits (248), Expect = 2e-20
 Identities = 103/458 (22%), Positives = 189/458 (41%), Gaps = 81/458 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301
                + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1416

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1417 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1517



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 43/274 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SNFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENFNV---ATEESSEP 1611
             +     ++ N+ +AI++E F     A +  SEP
Sbjct: 947  LMTFGNYVLFNLLVAILVEGFQAEGDANKSESEP 980



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1603 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1658

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1659 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1718

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1719 LGVELF 1724



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1729 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1783

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1784 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1831



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 15/75 (20%), Positives = 43/75 (57%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAEDK 462
             +  + +A  +E +
Sbjct: 965 EGFQAEGDANKSESE 979


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score =  331 bits (848), Expect = 5e-90
 Identities = 193/605 (31%), Positives = 338/605 (55%), Gaps = 40/605 (6%)

Query: 1021 RRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEM 1080
            R  C +I+ H  F+  ++ +I L+   +A E   I+     R  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1081 LLKWVAYGF----KVYFTNAWCWLDFLIVDVSIISLVANWL---GYSELGPIKSLRTLRA 1133
             +K VA G+    + Y  ++W  LD L+V +S+I ++ + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1134 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTT 1193
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1441

Query: 1194 TSERFDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAA 1253
              +  D   + NKS+C    +    RW+  K N+DN+G   +SL  +A+  GW+DIMY  
Sbjct: 1442 --QGEDTRNITNKSDCAEASY----RWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDG 1495

Query: 1254 VDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMT 1313
            +D+   ++QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++    
Sbjct: 1496 LDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRR 1555

Query: 1314 EEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE 1373
            EE  K    ++K   K   KP     ++ + +V+ L T    D+ I  +I LN+VTM +E
Sbjct: 1556 EE--KRLRRLEKKRRKAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAME 1613

Query: 1374 TDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGLA 1432
               Q Q+  + L   N IF +IF  E V K++A   + +F   WN  D  +V+LSI+G+ 
Sbjct: 1614 HYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGIT 1673

Query: 1433 LSDL--IQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLF 1490
            L ++       ++PT+ R++R+ RI RVL+L++ A G+R LL  +M +LP + N+GLL  
Sbjct: 1674 LEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFM 1733

Query: 1491 LVMFIYSIFGMSNFAYVKKE-----SGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPI 1545
            L+ FI++  G+  F  ++ +      G+     F  FG + + LF ++T   W+G++   
Sbjct: 1734 LLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDT 1793

Query: 1546 LNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVAT 1605
            L     DCD          +  C N  I   +F S+++ +  ++VN+ IA+++++   + 
Sbjct: 1794 LR----DCDQ---------ESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESN 1840

Query: 1606 EESSE 1610
            +E+ E
Sbjct: 1841 KEAKE 1845



 Score =  145 bits (366), Expect = 4e-34
 Identities = 86/269 (31%), Positives = 148/269 (55%), Gaps = 14/269 (5%)

Query: 564 WLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTA 623
           W    +    IV   +   GI I I++NTL M +E++   E   N L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 624 EMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSW 683
           EM+LKL+   P+ Y +  +NIFD +IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 684 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCN---LP 740
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK A + +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 741 -RWHMHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFL 798
            R +      + + VF+IL  E W + +++ M  +  +     F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 799 ALLLSSFSADSLA-ASDEDGEMNNLQIAI 826
           A+L+  F A+ ++   D  G+++ +Q+ +
Sbjct: 961 AILVEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  140 bits (354), Expect = 9e-33
 Identities = 112/395 (28%), Positives = 178/395 (45%), Gaps = 96/395 (24%)

Query: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQR 1058
            P ++  +SQ    + W LR  C     + WFE   + +ILL+   L      EDI  + +
Sbjct: 58   PVVFFYLSQDSRPRSWCLRTVC-----NPWFERISMLVILLNCVTLGMFRPCEDIACDSQ 112

Query: 1059 RVIRTILEYADKVFTYIFIMEMLLKWVA---YGFKVYFTNAWCWLDFLIVDVSIISLVAN 1115
            R  R +  + D +F + F +EM++K VA   +G K Y  + W  LDF IV       +A 
Sbjct: 113  RC-RILQAFDDFIFAF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV-------IAG 163

Query: 1116 WLGYS---ELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
             L YS   +     ++RT+R LRPLRA++R   MR++V  LL  +P + NVLL+C   + 
Sbjct: 164  MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

Query: 1173 IFSIMGVNLFAG--------------------KFYYCINTTTSERFDISE--VNNKSECE 1210
            IF I+GV L+AG                    + YY         F  S+   N    C 
Sbjct: 224  IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCR 283

Query: 1211 SL-----------------------MHTGQVRW--------------LNVKVNYDNVGLG 1233
            S+                        +T  V W                  +N+DN+G  
Sbjct: 284  SVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYA 343

Query: 1234 YLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGV 1293
            ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSFF +NL + V
Sbjct: 344  WIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSFFMINLCLVV 393

Query: 1294 IIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGS 1328
            I   F++ K++   +   M E++ ++ +    L S
Sbjct: 394  IATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/373 (25%), Positives = 169/373 (45%), Gaps = 34/373 (9%)

Query: 107 ATPALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP-------PPWSKN 159
           A    + LS  S  R   ++ + +  F    M+ IL NCV + M  P           + 
Sbjct: 57  APVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRI 116

Query: 160 VEYTFTGIYTF---ESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNIS 216
           ++     I+ F   E ++K++A G       +L D WN LDF +++   L   +DL N+S
Sbjct: 117 LQAFDDFIFAFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS 175

Query: 217 --ALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
             A+RT RVLR L+ I  +P ++ +V  L+ ++  L +V++L  F   +F +VG+QL+ G
Sbjct: 176 FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235

Query: 275 NLRQKCV---RWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWA 331
            LR +C     +  P +     +Y  +    +          G  S  +  T        
Sbjct: 236 LLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGG 295

Query: 332 TNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDT 391
                D++AY S          SN   +  N            C     NP  G  ++D 
Sbjct: 296 PPCGLDYEAYNS---------SSNTTCVNWNQYYT-------NCSAGEHNPFKGAINFDN 339

Query: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
             +A++A+F+++T + W ++    + A      I+F+++I +GSF++INL L V+A  ++
Sbjct: 340 IGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 399

Query: 452 E--QNEATLAEDK 462
           E  Q E+ L  ++
Sbjct: 400 ETKQRESQLMREQ 412



 Score =  117 bits (292), Expect = 1e-25
 Identities = 112/504 (22%), Positives = 204/504 (40%), Gaps = 125/504 (24%)

Query: 345  EGNFYFLEGSNDALLCGNSSDAGHCPEG-YECIKTGRNPNYGYTSYDTFSWAFLALFRLM 403
            +G F+  +G +      N ++   C E  Y  ++   N       +D    A ++LF L 
Sbjct: 1435 KGKFFVCQGEDTR----NITNKSDCAEASYRWVRHKYN-------FDNLGQALMSLFVLA 1483

Query: 404  TQDYWENLFQLTLRAAGKTY----------MIFFVVIIFLGSFYLINLILAVVAMAYAEQ 453
            ++D W ++    L A G             +++F+  + + +F+++N+ + VV       
Sbjct: 1484 SKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVV------ 1537

Query: 454  NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTS 513
                            +   K ++HQEE E  +  +                        
Sbjct: 1538 ----------------ENFHKCRQHQEEEEARRREEK----------------------- 1558

Query: 514  QGEKGAPRQSSSGDSGISDAMEELEEAHQK--CPPWWYKCAHKVLIWNCCAPWLKFKNII 571
                                +  LE+  +K  C P++             + + +F+ ++
Sbjct: 1559 -------------------RLRRLEKKRRKAQCKPYY-------------SDYSRFRLLV 1586

Query: 572  HLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIA 631
            H +    ++DL IT  I LN + MAMEHY   +  D  L + N +FT IF  E V KL+A
Sbjct: 1587 HHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVA 1646

Query: 632  MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQG----------LSVLRSFRLLRVFKLAK 681
                 +FQ  WN  D  IV LS++ + L  ++           + ++R  R+ RV KL K
Sbjct: 1647 FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK 1706

Query: 682  SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPR 741
                +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG    +  C     C    
Sbjct: 1707 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG----DLECDETHPCEGLG 1762

Query: 742  WH--MHDFFHSFLIVFRILCGE-WIETMWDCMEVAGQ-AMCLTV------FLMVMVIGNL 791
             H    +F  +FL +FR+  G+ W   M D +    Q + C         F+  ++    
Sbjct: 1763 RHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF 1822

Query: 792  VVLNLFLALLLSSFSADSLAASDE 815
            V++N+ +A+L+      +  A +E
Sbjct: 1823 VLVNVVIAVLMKHLEESNKEAKEE 1846



 Score =  103 bits (258), Expect = 1e-21
 Identities = 72/301 (23%), Positives = 148/301 (49%), Gaps = 40/301 (13%)

Query: 1338 PQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVE---TDNQSQLKVDILYNINMIFII 1394
            PQ++ + + + ++T + FD  ++++I LN +T+ +E    D  S  ++ +  + N IF  
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLS-NYIFTA 1319

Query: 1395 IFTGECVLKMLAL-----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRV 1449
            +F  E  +K++AL      Q Y    WN+ D ++V++S++ + +S +         + RV
Sbjct: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379

Query: 1450 IRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNF----- 1504
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F     
Sbjct: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF 1439

Query: 1505 -------AYVKKESG--------IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSG 1549
                     +  +S         +   +NF+  G +++ LF + +  GW  ++   L++ 
Sbjct: 1440 VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAV 1499

Query: 1550 PPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESS 1609
              D  P + +          NP + + +F S+++I    V+NM++ +++ENF+   +   
Sbjct: 1500 GVDQQPIMNH----------NPWM-LLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQE 1548

Query: 1610 E 1610
            E
Sbjct: 1549 E 1549



 Score =  100 bits (249), Expect = 1e-20
 Identities = 103/459 (22%), Positives = 190/459 (41%), Gaps = 81/459 (17%)

Query: 861  ADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLELDHLNFINNPYL 920
            ++ +G    +G+  P      PPE   +K    L  +  + GPP+   L  LN    PY 
Sbjct: 577  SEASGRTVGSGKVYPTVHTSPPPETLKEK---ALVEVAASSGPPT---LTSLNIPPGPYS 630

Query: 921  TIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCST------------- 967
            ++   +             ET +    + S K   P    +S  C               
Sbjct: 631  SMHKLL-------------ETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

Query: 968  ---ADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024
               AD + P+ D E   E   + +  +    +   +R   L  D        +W L    
Sbjct: 678  VELADREMPDSDSEAVYEFTQDAQHSD--LRDPHSRRQRSLGPDAEPSSVLAFWRLICDT 735

Query: 1025 F-KIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLK 1083
            F KIV+  +F   I+  IL+++ ++  E  Y EQ   +   LE ++ VFT +F +EMLLK
Sbjct: 736  FRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLK 793

Query: 1084 WVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRF 1143
             + YG   Y  N +   D +IV +S+  +V       + G +  LRT R +R L+ +   
Sbjct: 794  LLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 1144 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEV 1203
              ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF        SER   +  
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF-------ASERDGDTLP 901

Query: 1204 NNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263
            + K                   N+D++    +++ Q+ T + W  ++Y  + S       
Sbjct: 902  DRK-------------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMAS------- 935

Query: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1302
                + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 936  ---TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 70/283 (24%), Positives = 133/283 (46%), Gaps = 43/283 (15%)

Query: 563  PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDN--VLTVGNLVFTGI 620
            P  +F+ + H I+     D  + + I LN + +AME   +  H      LT+ N +FT +
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 621  FTAEMVLKLIAMD----PYEYFQQGWNIFDSIIVTLSLVELGLANVQG--------LSVL 668
            F AEM +K++A+        Y +  WN+ D ++V +S++++ ++ V          L VL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 669  RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYK 727
            R  R LR  ++      L ++++ + +S+  +GN+ ++      IF ++G+QLF GK + 
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFF- 1439

Query: 728  ECVCKIALDCNLP----------RWHMH----DFFHSFLIVFRILCGE--WIETMWDCME 771
              VC+     N+           RW  H    D     L+   +L  +  W++ M+D ++
Sbjct: 1440 --VCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497

Query: 772  VAG---------QAMCLTVFLMVMVIGNLVVLNLFLALLLSSF 805
              G             L  F+  ++I    VLN+F+ +++ +F
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 49/180 (27%), Positives = 90/180 (50%), Gaps = 17/180 (9%)

Query: 112  YLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVE--------YT 163
            Y+  P S  R    +++ H +F   +++ I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 164  FTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVD---------LGN 214
            FT ++  E  +K++A G+C  +  +LR  WN LD  +++++ +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 215  ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
            +  LR  R LR L+ I+   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 69/261 (26%), Positives = 118/261 (45%), Gaps = 40/261 (15%)

Query: 1349 LVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR 1408
            +V  + F   IMI I +N ++M +E   Q +   + L   N++F  +F  E +LK+L   
Sbjct: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798

Query: 1409 QY-YFTVGWNIFDFVVVILS---IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRG 1464
             + Y    +NIFD V+V++S   IVG     L            V+R  R+ RVL+L+R 
Sbjct: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRF 847

Query: 1465 AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----SNFAYVKKESGIDDMFNFE 1520
               ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF+
Sbjct: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFD 907

Query: 1521 TFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCS 1580
            +   +I+ +F+I T   W+ +L                       G     S    +F +
Sbjct: 908  SLLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIA 946

Query: 1581 YIIISFLIVVNMYIAIILENF 1601
             +     ++ N+ +AI++E F
Sbjct: 947  LMTFGNYVLFNLLVAILVEGF 967



 Score = 65.5 bits (158), Expect = 5e-10
 Identities = 44/155 (28%), Positives = 84/155 (54%), Gaps = 13/155 (8%)

Query: 126 KVLIHALFSMFIMITILTNCVFMTMS---DPPPWSKNVEYT---FTGIYTFESLIKILAR 179
           K++    F   IMI IL N + M +     P   +  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 180 GFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDL--GNISALRTFRVLRALKTITVIPGLK 237
           G     F ++++P+N  D  VI++  + E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 238 TIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLF 272
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 47/167 (28%), Positives = 80/167 (47%), Gaps = 17/167 (10%)

Query: 561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 620
           C PW  F+ I  L+++   V LG         +F   E          +L   +      
Sbjct: 79  CNPW--FERISMLVILLNCVTLG---------MFRPCEDIACDSQRCRILQAFDDFIFAF 127

Query: 621 FTAEMVLKLIAMDPYE---YFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLR 675
           F  EMV+K++A+  +    Y    WN  D  IV   ++E  L L NV   S +R+ R+LR
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLR 186

Query: 676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 722
             +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 1355 FDITIMILICLNMVTMM-------VETDNQSQLKVDILYNINMIFIIIFTGECVLKMLAL 1407
            F+   M++I LN VT+        +  D+Q   +  IL   +      F  E V+KM+AL
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQ---RCRILQAFDDFIFAFFAVEMVVKMVAL 139

Query: 1408 ----RQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIR 1463
                ++ Y    WN  DF +VI  ++  +L        +    F  +R  R+ R LR I 
Sbjct: 140  GIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAIN 192

Query: 1464 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFA 1505
                +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 193  RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 31/126 (24%), Positives = 69/126 (54%), Gaps = 15/126 (11%)

Query: 158  KNVEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISA 217
            K   Y FT I+  ES+ K++A GF      F +D WN LD ++++++ +   ++   ++A
Sbjct: 1626 KICNYIFTVIFVLESVFKLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNA 1681

Query: 218  -----------LRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFAL 266
                       +R  R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA 
Sbjct: 1682 SLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAA 1741

Query: 267  VGLQLF 272
            +G++LF
Sbjct: 1742 LGVELF 1747



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 14/109 (12%)

Query: 369  CPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM---- 424
            C E + C   GR     + ++  F  AFL LFR+ T D W  + + TLR   +       
Sbjct: 1752 CDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNT 1806

Query: 425  ----IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQ 469
                I+FV  +    F L+N+++AV+ M + E++     E+ E E E +
Sbjct: 1807 VISPIYFVSFVLTAQFVLVNVVIAVL-MKHLEESNKEAKEEAELEAELE 1854



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 16/74 (21%), Positives = 42/74 (56%), Gaps = 1/74 (1%)

Query: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVA 447
           ++D+  WA + +F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 448 MAYAEQNEATLAED 461
             + +  E +  ED
Sbjct: 965 EGF-QAEEISKRED 977


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,350,099
Number of Sequences: 37866
Number of extensions: 3452331
Number of successful extensions: 22224
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 166
Number of HSP's that attempted gapping in prelim test: 17027
Number of HSP's gapped (non-prelim): 2700
length of query: 1836
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1719
effective length of database: 13,817,196
effective search space: 23751759924
effective search space used: 23751759924
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.