Search of human proteins with 93141210

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93141210 sodium channel, voltage-gated, type II, alpha
isoform 1 [Homo sapiens]
         (2005 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93141212 sodium channel, voltage-gated, type II, alpha isofor...  3999   0.0  
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor...  3999   0.0  
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor...  3997   0.0  
gi|126362949 sodium channel, voltage-gated, type III, alpha isof...  3490   0.0  
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ...  3484   0.0  
gi|126362947 sodium channel, voltage-gated, type III, alpha isof...  3399   0.0  
gi|126362955 sodium channel, voltage-gated, type III, alpha isof...  3397   0.0  
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s...  3100   0.0  
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo...  2993   0.0  
gi|237512982 voltage-gated sodium channel type V alpha isoform f...  2435   0.0  
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...  2419   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...  2418   0.0  
gi|150417967 voltage-gated sodium channel type V alpha isoform c...  2414   0.0  
gi|150417969 voltage-gated sodium channel type V alpha isoform d...  2367   0.0  
gi|237512980 voltage-gated sodium channel type V alpha isoform e...  2345   0.0  
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ...  2118   0.0  
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi...  1869   0.0  
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom...  1343   0.0  
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo...  1302   0.0  
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated...  1018   0.0  
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1...   426   e-118
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1...   420   e-117
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ...   420   e-117
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   338   4e-92
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   338   4e-92
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...   337   7e-92
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...   333   1e-90

>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3999 bits (10370), Expect = 0.0
 Identities = 2005/2005 (100%), Positives = 2005/2005 (100%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
            GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540

Query: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
            LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
            FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
            STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720

Query: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
            SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780

Query: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
            YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840

Query: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
            ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900

Query: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
            QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960

Query: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
            TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020

Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
            IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080

Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
            SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140

Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
            SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200

Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
            CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260

Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
            WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320

Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
            EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380

Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
            NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440

Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
            PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500

Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
            MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560

Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
            NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620

Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
            SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680

Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
            NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740

Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
            SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800

Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
            VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860

Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
            FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920

Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
            LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980

Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
            PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
            [Homo sapiens]
          Length = 2005

 Score = 3999 bits (10370), Expect = 0.0
 Identities = 2005/2005 (100%), Positives = 2005/2005 (100%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
            GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540

Query: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
            LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
            FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
            STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720

Query: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
            SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780

Query: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
            YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840

Query: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
            ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900

Query: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
            QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960

Query: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
            TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020

Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
            IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080

Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
            SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140

Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
            SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200

Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
            CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260

Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
            WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320

Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
            EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380

Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
            NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440

Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
            PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500

Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
            MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560

Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
            NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620

Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
            SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680

Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
            NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740

Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
            SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800

Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
            VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860

Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
            FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920

Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
            LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980

Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
            PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
            [Homo sapiens]
          Length = 2005

 Score = 3997 bits (10365), Expect = 0.0
 Identities = 2004/2005 (99%), Positives = 2005/2005 (100%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK
Sbjct: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK
Sbjct: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDFTVITFAYVTEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL
Sbjct: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP
Sbjct: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI
Sbjct: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540
            GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS
Sbjct: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFS 540

Query: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
            LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST
Sbjct: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600

Query: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
            FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP
Sbjct: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660

Query: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720
            STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE
Sbjct: 661  STLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEE 720

Query: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780
            SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH
Sbjct: 721  SRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEH 780

Query: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840
            YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL
Sbjct: 781  YPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGL 840

Query: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900
            ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM
Sbjct: 841  ANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGM 900

Query: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960
            QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL
Sbjct: 901  QLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCL 960

Query: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020
            TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK
Sbjct: 961  TVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRK 1020

Query: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080
            IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS
Sbjct: 1021 IREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGS 1080

Query: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140
            SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS
Sbjct: 1081 SVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSS 1140

Query: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200
            SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT
Sbjct: 1141 SEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKT 1200

Query: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260
            CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK
Sbjct: 1201 CYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLK 1260

Query: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320
            WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF
Sbjct: 1261 WVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRF 1320

Query: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380
            EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV
Sbjct: 1321 EGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVV 1380

Query: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440
            NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ
Sbjct: 1381 NNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ 1440

Query: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
            PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA
Sbjct: 1441 PKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500

Query: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560
            MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT
Sbjct: 1501 MKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMT 1560

Query: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620
            NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV
Sbjct: 1561 NILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV 1620

Query: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680
            SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS
Sbjct: 1621 SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1680

Query: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740
            NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS
Sbjct: 1681 NFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGS 1740

Query: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
            SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE
Sbjct: 1741 SVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800

Query: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860
            VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA
Sbjct: 1801 VWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFA 1860

Query: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
            FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL
Sbjct: 1861 FTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920

Query: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980
            LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK
Sbjct: 1921 LKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTK 1980

Query: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005
            PEKEKFEKDKSEKEDKGKDIRESKK
Sbjct: 1981 PEKEKFEKDKSEKEDKGKDIRESKK 2005


>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
            [Homo sapiens]
          Length = 2000

 Score = 3490 bits (9050), Expect = 0.0
 Identities = 1750/2010 (87%), Positives = 1865/2010 (92%), Gaps = 15/2010 (0%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SNVSQAS +SR++P LP NGKMHS VDCNGVVSLVG
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG 658

Query: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717
            GPS LTS  GQL PEGTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEE
Sbjct: 659  GPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEE 718

Query: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777
            LEESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMA
Sbjct: 719  LEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMA 778

Query: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837
            MEHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLME
Sbjct: 779  MEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLME 838

Query: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897
            LGL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 839  LGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 898

Query: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957
            VGMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQT
Sbjct: 899  VGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 958

Query: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017
            MCL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+V
Sbjct: 959  MCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYV 1018

Query: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077
            K K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG
Sbjct: 1019 KNKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSG 1073

Query: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135
            +G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKL
Sbjct: 1074 VGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKL 1133

Query: 1136 NATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWW 1195
            NATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WW
Sbjct: 1134 NATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWW 1193

Query: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
            NLRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL
Sbjct: 1194 NLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1253

Query: 1256 EMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLR 1315
            EMLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLR
Sbjct: 1254 EMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLR 1313

Query: 1316 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMF 1375
            ALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MF
Sbjct: 1314 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMF 1373

Query: 1376 DVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1435
            D+S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR
Sbjct: 1374 DISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSR 1430

Query: 1436 NVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1495
            +V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK
Sbjct: 1431 DVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQK 1490

Query: 1496 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQ 1555
            KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ
Sbjct: 1491 KYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQ 1550

Query: 1556 SQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELI 1615
             + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+I
Sbjct: 1551 GKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMI 1610

Query: 1616 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1675
            EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA
Sbjct: 1611 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYA 1670

Query: 1676 IFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDK 1735
            IFGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD 
Sbjct: 1671 IFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730

Query: 1736 DHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1795
             HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF
Sbjct: 1731 IHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDF 1790

Query: 1796 EMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1855
            EMFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL
Sbjct: 1791 EMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCL 1850

Query: 1856 DILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRA 1915
            DILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR 
Sbjct: 1851 DILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRN 1910

Query: 1916 YRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSY 1975
            +R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSY
Sbjct: 1911 FRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSY 1970

Query: 1976 DSVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
            DSVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1971 DSVTKPDKEKFEKDKPEKESKGKEVRENQK 2000


>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
            sapiens]
          Length = 1998

 Score = 3484 bits (9034), Expect = 0.0
 Identities = 1759/2005 (87%), Positives = 1875/2005 (93%), Gaps = 14/2005 (0%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            M Q+VLVPPGPDSF FFTRESLAAIE+RIAEEKAK PK ++KD DDENGPKPNSDLEAGK
Sbjct: 1    MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKD-DDENGPKPNSDLEAGK 59

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIVLNKGKAI RFSAT ALYILTPFNP+RK
Sbjct: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            +AIKILVHSLF+MLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKI+ARGFC
Sbjct: 120  IAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFC 179

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+QWPP N+S E +     N ++
Sbjct: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEK-NITV 298

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + NGT  N TV  F+W  YI+D  + YFLEG  DALLCGNSSDAGQCPEGY+CVKAGRNP
Sbjct: 299  NYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNP 358

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI
Sbjct: 359  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 418

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQ-AAAAAASAESRDFSGAGG 479
            LAVVAMAYEEQNQATLEEAEQKEAEFQQM+EQLKKQQE AQ AA A AS  SR+ S AG 
Sbjct: 419  LAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGR 478

Query: 480  IGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN-DRVRKSESEDSIRRKGFR 538
            +   S+SSS ASKLSSKS KE +NRRKK+KQKEQSG EEK+ D  +KSESEDSIRRKGFR
Sbjct: 479  L---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535

Query: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
            FS+EG+RLTYEKR+SSPHQSLLSIRGSLFSPRRNSR SLFSFRGRAKD+GSENDFADDEH
Sbjct: 536  FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEH 595

Query: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
            STFEDN+SRRDSLFVP RHGERR+SN+SQ SR+SR+L + P NGKMHS VDCNGVVSLVG
Sbjct: 596  STFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG 655

Query: 659  GPSTLTS-AGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEE 717
            GPS  TS  GQLLPEGTTTETE+RKRRSSS+HVSMD LEDP+ RQRAMSIASILTNT+EE
Sbjct: 656  GPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEE 715

Query: 718  LEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMA 777
            LEESRQKCPPCWYKF+N+ LIWDC   WLKVKH+VNLVVMDPFVDLAITICIVLNTLFMA
Sbjct: 716  LEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMA 775

Query: 778  MEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLME 837
            MEHYPMT+ F++VL+VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV+LSL+E
Sbjct: 776  MEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVE 835

Query: 838  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 897
            LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV
Sbjct: 836  LGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 895

Query: 898  VGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQT 957
            VGMQLFGKSYK+CVCKI++DC+LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ 
Sbjct: 896  VGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQA 955

Query: 958  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFV 1017
            MCLTVFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDDNEMNNLQIAV RM KG+ +V
Sbjct: 956  MCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYV 1015

Query: 1018 KRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSG 1077
            KRKI EFIQ++F+RKQK LDEIKPL+DLNNKKDSC+SNHT  EIGKDL+YLKD NGTTSG
Sbjct: 1016 KRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTA-EIGKDLDYLKDVNGTTSG 1074

Query: 1078 IG--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKL 1135
            IG  SSVEKY++DESDYMSFINNPSLTVTVPIAVGESDFENLNTE+FSSESD+EESKEKL
Sbjct: 1075 IGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKL 1134

Query: 1136 N-ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLW 1194
            N ++SSSEGSTVDIGAP E EQP VEPEE+LEPEACFTE CV++FKCCQI++EEG+GK W
Sbjct: 1135 NESSSSSEGSTVDIGAPVE-EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQW 1193

Query: 1195 WNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFI 1254
            WNLR+TC++IVEHNWFETFIVFMILLSSGALAFEDIYI+QRKTIKTMLEYADKVFTYIFI
Sbjct: 1194 WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFI 1253

Query: 1255 LEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1314
            LEMLLKWVAYG+Q YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL
Sbjct: 1254 LEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPL 1313

Query: 1315 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM 1374
            RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN TTG+ 
Sbjct: 1314 RALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDR 1373

Query: 1375 FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDS 1434
            FD+  VNN+++C  LIE N+TARWKNVKVNFDNVG GYLSLLQVATFKGWMDIMYAAVDS
Sbjct: 1374 FDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDS 1433

Query: 1435 RNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1494
            RNVELQPKYE++LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
Sbjct: 1434 RNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ 1493

Query: 1495 KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDD 1554
            KKYYNAMKKLGSKKPQKPIPRP NKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDD
Sbjct: 1494 KKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD 1553

Query: 1555 QSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAEL 1614
            QS+ +T IL  INLVFIVLFTGECVLKLISLR+YYFTIGWNIFDFVVVILSIVGMFLAEL
Sbjct: 1554 QSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAEL 1613

Query: 1615 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1674
            IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
Sbjct: 1614 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY 1673

Query: 1675 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPD 1734
            AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP+
Sbjct: 1674 AIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPN 1733

Query: 1735 KDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1794
            K +PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
Sbjct: 1734 KVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD 1793

Query: 1795 FEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC 1854
            FEMFYEVWEKFDPDATQF+EF KLS FA AL+PPL + +PNK+QLIAMDLPMVSGDRIHC
Sbjct: 1794 FEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHC 1853

Query: 1855 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQR 1914
            LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSY+PITTTLKRKQEEVSA+IIQR
Sbjct: 1854 LDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQR 1913

Query: 1915 AYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTS-PP 1973
            AYRR+LLK+ VK+ S  Y K+K K      IKED +ID++NENS  EKTD+T ST + PP
Sbjct: 1914 AYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPP 1973

Query: 1974 SYDSVTKPEKEKFEKDKSEKEDKGK 1998
            SYD VTKP  EK E++  +++ KGK
Sbjct: 1974 SYDRVTKPIVEKHEQEGKDEKAKGK 1998


>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
            [Homo sapiens]
          Length = 1951

 Score = 3399 bits (8813), Expect = 0.0
 Identities = 1712/2009 (85%), Positives = 1824/2009 (90%), Gaps = 62/2009 (3%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDF+VI  AYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SN                                  
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624

Query: 659  GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718
                          GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 625  --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670

Query: 719  EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778
            EESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 671  EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730

Query: 779  EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838
            EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 731  EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790

Query: 839  GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898
            GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 791  GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850

Query: 899  GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958
            GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 851  GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910

Query: 959  CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018
            CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 911  CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970

Query: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078
             K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 971  NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025

Query: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136
            G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085

Query: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196
            ATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WWN
Sbjct: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
            LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
            MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265

Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376
            LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325

Query: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436
            +S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382

Query: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
            V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442

Query: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556
            YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ 
Sbjct: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502

Query: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616
            + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562

Query: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676
            KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622

Query: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736
            FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD  
Sbjct: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682

Query: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796
            HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742

Query: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856
            MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802

Query: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916
            ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862

Query: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976
            R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922

Query: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
            SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951


>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
            [Homo sapiens]
          Length = 1951

 Score = 3397 bits (8807), Expect = 0.0
 Identities = 1711/2009 (85%), Positives = 1823/2009 (90%), Gaps = 62/2009 (3%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGK 60
            MAQ++LVPPGP+SFR FTRESLAAIE+R AEEKAK+PK+E+ D DDEN PKPNSDLEAGK
Sbjct: 1    MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQ-DNDDENKPKPNSDLEAGK 59

Query: 61   SLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRK 120
            +LPFIYGDIPPEMVS PLEDLDPYYINKKTFIV+NKGKAI RFSAT ALYILTP NP+RK
Sbjct: 60   NLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRK 119

Query: 121  LAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 180
            +AIKILVHSLF+MLIMCTILTNCVFMT+SNPPDWTKNVEYTFTGIYTFESLIKILARGFC
Sbjct: 120  IAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFC 179

Query: 181  LEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGA 240
            LEDFTFLRDPWNWLDF+VI  AYVTEFV LGNVSALRTFRVLRALKTISVIPGLKTIVGA
Sbjct: 180  LEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGA 239

Query: 241  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSL 300
            LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP +S+FE N TS+FN ++
Sbjct: 240  LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTM 299

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            D NGT  N T+S FNW +YI D SHFY L+GQ D LLCGN SDAGQCPEGYICVKAGRNP
Sbjct: 300  DSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNP 359

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            NYGYTSFDTFSWAFLSLFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIFLGSFYL+NLI
Sbjct: 360  NYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLI 419

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQA AAA SA SRDFSG GG+
Sbjct: 420  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAA-SAASRDFSGIGGL 478

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKE--QSGEEEKNDRVRKSESEDSIRRKGFR 538
            G   ESSS ASKLSSKS KE +NRRKK++Q+E  +   + + D   KSESEDS++R  F 
Sbjct: 479  GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFL 538

Query: 539  FSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEH 598
            FS++G+RLT +K+F SPHQSLLSIRGSLFSPRRNS+ S+FSFRGRAKD+GSENDFADDEH
Sbjct: 539  FSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

Query: 599  STFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG 658
            STFED++SRRDSLFVPHRHGERR+SN                                  
Sbjct: 599  STFEDSESRRDSLFVPHRHGERRNSN---------------------------------- 624

Query: 659  GPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEEL 718
                          GTTTETE+RKRR SSY +SM++LED + RQRA+SIASILTNTMEEL
Sbjct: 625  --------------GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEEL 670

Query: 719  EESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAM 778
            EESRQKCPPCWY+FAN+ LIWDCC  WLKVKHLVNL+VMDPFVDLAITICIVLNTLFMAM
Sbjct: 671  EESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAM 730

Query: 779  EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL 838
            EHYPMTEQFSSVL+VGNLVFTGIFTAEM LKIIAMDPYYYFQEGWNIFDG IVSLSLMEL
Sbjct: 731  EHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMEL 790

Query: 839  GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 898
            GL+NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV
Sbjct: 791  GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 850

Query: 899  GMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 958
            GMQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM
Sbjct: 851  GMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTM 910

Query: 959  CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVK 1018
            CL VFM+VMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGID+VK
Sbjct: 911  CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVK 970

Query: 1019 RKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGI 1078
             K+RE  QKAF RK K ++  +      NK DSC+SN+T IEI K+LNYL+DGNGTTSG+
Sbjct: 971  NKMRECFQKAFFRKPKVIEIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGV 1025

Query: 1079 G--SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLN 1136
            G  SSVEKYV+DE+DYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSES++EESKEKLN
Sbjct: 1026 GTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLN 1085

Query: 1137 ATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWN 1196
            ATSSSEGSTVD+  P EGEQ E EPEE L+PEACFTE C++KF  CQ+S EEGKGK+WWN
Sbjct: 1086 ATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWN 1145

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
            LRKTCY IVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE
Sbjct: 1146 LRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1205

Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
            MLLKWVAYGFQ YFTNAWCWLDFLIVDVSLVSL ANALGYSELGAIKSLRTLRALRPLRA
Sbjct: 1206 MLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRA 1265

Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFD 1376
            LSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC+N TTG MFD
Sbjct: 1266 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFD 1325

Query: 1377 VSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRN 1436
            +S VNN S+C+AL    + ARWKNVKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR+
Sbjct: 1326 ISDVNNLSDCQAL---GKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRD 1382

Query: 1437 VELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
            V+LQP YE+NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK
Sbjct: 1383 VKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1442

Query: 1497 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQS 1556
            YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVT+QVFDISIMILICLNMVTMMVETDDQ 
Sbjct: 1443 YYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQG 1502

Query: 1557 QEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE 1616
            + MT +L  INLVFIVLFTGE VLKL+SLR+YYFTIGWNIFDFVVVILSIVGMFLAE+IE
Sbjct: 1503 KYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIE 1562

Query: 1617 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676
            KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI
Sbjct: 1563 KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1622

Query: 1677 FGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736
            FGMSNFAYVK+E GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDPD  
Sbjct: 1623 FGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTI 1682

Query: 1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1796
            HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE
Sbjct: 1683 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFE 1742

Query: 1797 MFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1856
            MFYEVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD
Sbjct: 1743 MFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1802

Query: 1857 ILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAY 1916
            ILFAFTKRVLGESGEMDALRIQME+RFMASNPSKVSYEPITTTLKRKQEEVSA IIQR +
Sbjct: 1803 ILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNF 1862

Query: 1917 RRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYD 1976
            R YLLKQ++K +SS Y K+  K     PIK+D +IDKLN NSTPEKTD + STTSPPSYD
Sbjct: 1863 RCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYD 1922

Query: 1977 SVTKPEKEKFEKDKSEKEDKGKDIRESKK 2005
            SVTKP+KEKFEKDK EKE KGK++RE++K
Sbjct: 1923 SVTKPDKEKFEKDKPEKESKGKEVRENQK 1951


>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
            sapiens]
          Length = 1977

 Score = 3100 bits (8038), Expect = 0.0
 Identities = 1573/2006 (78%), Positives = 1746/2006 (87%), Gaps = 34/2006 (1%)

Query: 4    SVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLP 63
            ++L PPGP SF  FT++SLA IEQRIAE K+K PK+E+KD DDE  PKP+SDLEAGK LP
Sbjct: 2    AMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKD-DDEEAPKPSSDLEAGKQLP 60

Query: 64   FIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
            FIYGDIPP MVS PLEDLDPYY +KKTFIVLNKGK I RF+ATPALY+L+PF+P+R+++I
Sbjct: 61   FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI 120

Query: 124  KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
            KILVHSLF+MLIMCTILTNC+FMTM+NPPDWTKNVEYTFTGIYTFESL+KILARGFC+ +
Sbjct: 121  KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE 180

Query: 184  FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
            FTFLRDPWNWLDF VI FAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
Sbjct: 181  FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 240

Query: 244  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
            SVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC                 F NSL+ N
Sbjct: 241  SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC-----------------FRNSLENN 283

Query: 304  GTTFNRTVSIFNWDEYIED-KSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNY 362
             T      SI N  E  ED + +FY+LEG  DALLCG S+D+GQCPEGY CVK GRNP+Y
Sbjct: 284  ETL----ESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDY 339

Query: 363  GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILA 422
            GYTSFDTFSWAFL+LFRLMTQD+WENLYQ TLRAAGKTYMIFFV+VIFLGSFYLINLILA
Sbjct: 340  GYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILA 399

Query: 423  VVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGV 482
            VVAMAYEEQNQA +EEA+QKE EFQQML++LKK+QEEA+A AAAA AE      +  +G+
Sbjct: 400  VVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGL 458

Query: 483  FSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESEDSIRRKGFRFS 540
             SESSS  SKLSSKS KE +NRRKKK QK+ S  EEK D  ++ KSESEDSIRRK F   
Sbjct: 459  -SESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLG 517

Query: 541  LEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHST 600
            +EG R  +EKR S+P+QS LSIRGSLFS RR+SR SLFSF+GR +DIGSE +FADDEHS 
Sbjct: 518  VEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSI 577

Query: 601  FEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
            F DN+SRR SLFVPHR  ERR SN+SQASR+    P+LP+NGKMHSAVDCNGVVSLV G 
Sbjct: 578  FGDNESRRGSLFVPHRPQERRSSNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGR 634

Query: 661  STLTSA-GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELE 719
            S L    GQLLPEGTT +   +KRR SSY +S D+L DP  RQRAMS ASILTNT+EELE
Sbjct: 635  SALMLPNGQLLPEGTTNQIH-KKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELE 693

Query: 720  ESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAME 779
            ESRQKCPP WY+FA+  LIW+C   W+K K  +  +VMDPFVDLAITICIVLNTLFMAME
Sbjct: 694  ESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAME 753

Query: 780  HYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG 839
            H+PMTE+F +VL++GNLVFTGIF AEM LK+IAMDPY YFQ GWNIFD  IV+LSL+EL 
Sbjct: 754  HHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF 813

Query: 840  LANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 899
            LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG
Sbjct: 814  LADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873

Query: 900  MQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC 959
            MQLFGKSYKECVCKI++DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQ MC
Sbjct: 874  MQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 933

Query: 960  LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKR 1019
            L V+MMVMVIGNLVVLNLFLALLLSSFSSDNL A ++D + NNLQIAV R++KGI++VK+
Sbjct: 934  LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQ 993

Query: 1020 KIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG 1079
             +REFI KAF +K K   EI+  EDLN KK++ ISNHT  E+ K  N+LK+ +   SG G
Sbjct: 994  TLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFG 1052

Query: 1080 SSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATS 1139
            SSV+K+++++SD  SFI+NPSLTVTVPIA GESD EN+N EE SS+SD E SK +LN +S
Sbjct: 1053 SSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSS 1112

Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
            SSE STVD   P EGE+ E EP  S EPEACFT+ CVR+F CCQ++IE GKGK+WWN+RK
Sbjct: 1113 SSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRK 1172

Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLL 1259
            TCYKIVEH+WFE+FIV MILLSSGALAFEDIYIE++KTIK +LEYADK+FTYIFILEMLL
Sbjct: 1173 TCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLL 1232

Query: 1260 KWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSR 1319
            KW+AYG++ YFTNAWCWLDFLIVDVSLV+L AN LGYS+LG IKSLRTLRALRPLRALSR
Sbjct: 1233 KWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSR 1292

Query: 1320 FEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSV 1379
            FEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY CIN T G  F  S 
Sbjct: 1293 FEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQ 1352

Query: 1380 VNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVEL 1439
            V N SEC AL+  +Q  RWKN+KVNFDNVGLGYLSLLQVATFKGW  IMYAAVDS NV+ 
Sbjct: 1353 VPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDK 1412

Query: 1440 QPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN 1499
            QPKYE +LYMY+YFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYN
Sbjct: 1413 QPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYN 1472

Query: 1500 AMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEM 1559
            AMKKLGSKKPQKPIPRP NK QG +FD VT Q FDISIM+LICLNMVTMMVE + QSQ M
Sbjct: 1473 AMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHM 1532

Query: 1560 TNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYF 1619
            T +LYWIN+VFI+LFTGECVLKLISLR+YYFT+GWNIFDFVVVI+SIVGMFLA+LIE YF
Sbjct: 1533 TEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYF 1592

Query: 1620 VSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1679
            VSPTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
Sbjct: 1593 VSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM 1652

Query: 1680 SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPG 1739
            SNFAYVK+E GI+DMFNFETFGNSMICLFQITTSAGWDGLLAPILNS PPDCDP K HPG
Sbjct: 1653 SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPG 1712

Query: 1740 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1799
            SSV+GDCGNPSVGIF+FVSYIIISFLVVVNMYIAVILENFSVATEES EPLSEDDFEMFY
Sbjct: 1713 SSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFY 1772

Query: 1800 EVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1859
            EVWEKFDPDATQFIEF+KLSDFA ALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF
Sbjct: 1773 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILF 1832

Query: 1860 AFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY 1919
            AFTKRVLGESGEMD+LR QMEERFM++NPSKVSYEPITTTLKRKQE+VSA +IQRAYRRY
Sbjct: 1833 AFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY 1892

Query: 1920 LLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVT 1979
             L+Q VK +SSIY KD G   D    K+D   D +NENS+PEKTD T STTSPPSYDSVT
Sbjct: 1893 RLRQNVKNISSIYIKD-GDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVT 1951

Query: 1980 KPEKEKFEKDKSEKEDKGKDIRESKK 2005
            KP+KEK+E+D++EKEDKGKD +ESKK
Sbjct: 1952 KPDKEKYEQDRTEKEDKGKDSKESKK 1977


>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
            sapiens]
          Length = 1980

 Score = 2993 bits (7759), Expect = 0.0
 Identities = 1537/2027 (75%), Positives = 1730/2027 (85%), Gaps = 71/2027 (3%)

Query: 1    MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ---ERKDEDDENGPKPNSDLE 57
            MA  +L PPGPDSF+ FT ESLA IE+RIAE K K+P +     +++D+++ PKPNSDLE
Sbjct: 1    MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60

Query: 58   AGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNP 117
            AGKSLPFIYGDIP  +V+VPLED DPYY+ +KTF+VLN+GK + RFSATPALYIL+PFN 
Sbjct: 61   AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120

Query: 118  IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILAR 177
            IR++AIKIL+HS+F+M+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 121  IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180

Query: 178  GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 237
            GFC++ FTFLRDPWNWLDF+VI  AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181  GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240

Query: 238  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFN 297
            VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP       IN    FN
Sbjct: 241  VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP-------IN----FN 289

Query: 298  NSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG 357
             S   NGT        F+W+EYI +K++FY + G  + LLCGNSSDAGQCPEGY C+KAG
Sbjct: 290  ESYLENGTKG------FDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343

Query: 358  RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLI 417
            RNPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+
Sbjct: 344  RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403

Query: 418  NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASA-----ESR 472
            NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQAAA A SA     ++ 
Sbjct: 404  NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463

Query: 473  DFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESED 530
            +  G  G G    SSS  SKLSSKS KE +NRRKK+KQKE S  EEK D  +V KSESED
Sbjct: 464  EEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522

Query: 531  SIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRG--RAKDIG 588
             +RRK FR  L  +R+   ++FS  +QSLLSI GS F  R NS++S+FSFRG  R +D G
Sbjct: 523  GMRRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578

Query: 589  SENDFADDEHSTFEDNDSRRDSLFVPHRHGERR-----HSNVSQASRASRVLPILPMNGK 643
            SEN+FADDEHST E+++ RRDSLF+P R  ERR     +S  SQ SR+SR+ P L  + K
Sbjct: 579  SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638

Query: 644  MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
             +S VDCNGVVSL+GGP +    G+LLPE TT E EI+K+   S  VSMD L     + R
Sbjct: 639  RNSTVDCNGVVSLIGGPGSHIG-GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDR 696

Query: 704  AMSIASILTNTM-EELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVD 762
              SI S++TNT+ EELEES++KCPPCWYKFAN  LIW+C   W+K+K +VNL+VMDPFVD
Sbjct: 697  INSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVD 756

Query: 763  LAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEG 822
            LAITICIVLNTLFMAMEH+PMT QF  VL+VGNLVFTGIFTAEMFLK+IAMDPYYYFQEG
Sbjct: 757  LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEG 816

Query: 823  WNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 882
            WNIFDGFIVSLSLMEL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
Sbjct: 817  WNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 876

Query: 883  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE 942
            NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI+ DCELPRWHMHDFFHSFLIVFRVLCGE
Sbjct: 877  NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE 936

Query: 943  WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
            WIETMWDCMEVAGQ MCL VFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNN
Sbjct: 937  WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNN 996

Query: 1003 LQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIG 1062
            LQI+V R++KG+ + K K+  F+Q  F  KQ+  DE+KPL++L  KK +CI+NHT  +I 
Sbjct: 997  LQISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIH 1054

Query: 1063 KDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEF 1122
            ++ ++ K+GNGTTSGIGSSVEKY++DE D+MSFINNP+LTV VPIAVGESDFENLNTE+ 
Sbjct: 1055 RNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1113

Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
            SSESD E SK+KL+ TSSSEGST+DI    E E P  +PEE L+P+ACFTE CV++FKCC
Sbjct: 1114 SSESDPEGSKDKLDDTSSSEGSTIDIKPEVE-EVPVEQPEEYLDPDACFTEGCVQRFKCC 1172

Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
            Q++IEEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+L
Sbjct: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232

Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
            EYADKVFTYIFILEMLLKW AYGF  +FTNAWCWLDFLIV VSLVSL ANALGYSELGAI
Sbjct: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292

Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
            KSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352

Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTA-RWKNVKVNFDNVGLGYLSLLQVATF 1421
            +++C N T+   F++  VNN +EC+ L+E N T  RWKNVK+NFDNVG GYL+LLQVATF
Sbjct: 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATF 1412

Query: 1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
            KGWMDIMYAAVDSR  + QPKYEDN+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKK
Sbjct: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472

Query: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
            KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LI
Sbjct: 1473 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLI 1532

Query: 1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV 1601
            CLNMVTMMVETD QS++M NILYWINLVF++ FT ECVLK+ +LR+YYFTIGWNIFDFVV
Sbjct: 1533 CLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV 1592

Query: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
            VILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
Sbjct: 1593 VILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652

Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1721
            NIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL 
Sbjct: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712

Query: 1722 PILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV 1781
            PILN  PPDC  DK+HPGS  KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSV
Sbjct: 1713 PILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771

Query: 1782 ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIA 1841
            ATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFADAL+ PL + KPN ++LIA
Sbjct: 1772 ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIA 1831

Query: 1842 MDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLK 1901
            MDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSYEPITTTL+
Sbjct: 1832 MDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLR 1891

Query: 1902 RKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENST-P 1960
            RKQEEVSA+++QRAYR +L +             +G  C      + T  +KL    T  
Sbjct: 1892 RKQEEVSAVVLQRAYRGHLAR-------------RGFIC------KKTTSNKLENGGTHR 1932

Query: 1961 EKTDMTPSTTSPPSYDSVTKPEKEK---FEKDKSEKEDKGKDIRESK 2004
            EK + TPST S PSYDSVTKPEKEK    E+ + E+  + K++RESK
Sbjct: 1933 EKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979


>gi|237512982 voltage-gated sodium channel type V alpha isoform f
            [Homo sapiens]
          Length = 1962

 Score = 2435 bits (6310), Expect = 0.0
 Identities = 1290/2027 (63%), Positives = 1526/2027 (75%), Gaps = 122/2027 (6%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1120 EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDCVRK 1178
            +E +S    EES ++    S SEGST D+   AE  EQ     ++  +PE CFTE CVR+
Sbjct: 1062 DEENSLGTEEESSKQTPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRR 1121

Query: 1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTI 1238
              CC +   +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTI
Sbjct: 1122 CPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTI 1181

Query: 1239 KTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSE 1298
            K +LEYADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E
Sbjct: 1182 KVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAE 1241

Query: 1299 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNL 1358
            +G IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNL
Sbjct: 1242 MGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1301

Query: 1359 FAGKFYHCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQ 1417
            FAGKF  CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQ
Sbjct: 1302 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQ 1360

Query: 1418 VATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFN 1477
            VATFKGWMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFN
Sbjct: 1361 VATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1420

Query: 1478 QQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISI 1537
            QQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++I
Sbjct: 1421 QQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTI 1480

Query: 1538 MILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIF 1597
            M LICLNMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIF
Sbjct: 1481 MFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIF 1540

Query: 1598 DFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSL 1657
            DFVVVILSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSL
Sbjct: 1541 DFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSL 1600

Query: 1658 PALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWD 1717
            PALFNIGLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWD
Sbjct: 1601 PALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWD 1660

Query: 1718 GLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777
            GLL+PILN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILE
Sbjct: 1661 GLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILE 1719

Query: 1778 NFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKV 1837
            NFSVATEES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++
Sbjct: 1720 NFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQI 1779

Query: 1838 QLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPIT 1897
             LI MDLPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPIT
Sbjct: 1780 SLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPIT 1839

Query: 1898 TTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLN 1955
            TTL+RK EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++
Sbjct: 1840 TTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMS 1899

Query: 1956 ENST----PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
            EN +    P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1900 ENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1946


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score = 2419 bits (6268), Expect = 0.0
 Identities = 1294/2080 (62%), Positives = 1528/2080 (73%), Gaps = 175/2080 (8%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1120 EEFSSESDMEESKEK--------------------LNATSSSEGST------------VD 1147
            +E +S    EES ++                    ++AT+SSE                +
Sbjct: 1062 DEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAE 1121

Query: 1148 IGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQIS 1185
              AP  GE PE    E                        +PE CFTE CVR+  CC + 
Sbjct: 1122 PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1181

Query: 1186 IEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1245
              +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1182 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1241

Query: 1246 DKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1305
            DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSL
Sbjct: 1242 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1301

Query: 1306 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
            RTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361

Query: 1366 CINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGW 1424
            CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGW
Sbjct: 1362 CINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGW 1420

Query: 1425 MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484
            MDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK G
Sbjct: 1421 MDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1480

Query: 1485 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
            GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLN
Sbjct: 1481 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLN 1540

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVIL 1604
            MVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVIL
Sbjct: 1541 MVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVIL 1600

Query: 1605 SIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1664
            SIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIG
Sbjct: 1601 SIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1660

Query: 1665 LLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1724
            LLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PIL
Sbjct: 1661 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1720

Query: 1725 NSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1784
            N+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATE
Sbjct: 1721 NTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATE 1779

Query: 1785 ESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDL 1844
            ES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MDL
Sbjct: 1780 ESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDL 1839

Query: 1845 PMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQ 1904
            PMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK 
Sbjct: 1840 PMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKH 1899

Query: 1905 EEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST--- 1959
            EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +   
Sbjct: 1900 EEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPL 1959

Query: 1960 -PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
             P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 GPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1999


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score = 2418 bits (6267), Expect = 0.0
 Identities = 1294/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121

Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181

Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241

Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301

Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361

Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420

Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
            WMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480

Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540

Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600

Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660

Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720

Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779

Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839

Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899

Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959

Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score = 2414 bits (6255), Expect = 0.0
 Identities = 1291/2081 (62%), Positives = 1528/2081 (73%), Gaps = 176/2081 (8%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121

Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181

Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241

Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301

Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361

Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKG
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKG 1420

Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
            WMDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1421 WMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1480

Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1481 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1540

Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1541 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1600

Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1601 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1660

Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1661 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1720

Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1721 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1779

Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1780 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1839

Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1840 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1899

Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1900 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1959

Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1960 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 2000


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score = 2367 bits (6135), Expect = 0.0
 Identities = 1274/2081 (61%), Positives = 1511/2081 (72%), Gaps = 194/2081 (9%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMN--- 507

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                            H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 508  ----------------HLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVPWPL--RRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEIR--KRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISNH------TTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAA-------QGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT 1119
            ++       +   G   G G+                 +P   V VPIAV ESD ++   
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1120 EEFSSESDMEESKEK---------------------LNATSSSEGST------------V 1146
            +E +S    EES ++                     ++AT+SSE                
Sbjct: 1062 DEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKA 1121

Query: 1147 DIGAPAEGEQPEVEPEESL----------------------EPEACFTEDCVRKFKCCQI 1184
            +  AP  GE PE    E                        +PE CFTE CVR+  CC +
Sbjct: 1122 EPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181

Query: 1185 SIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1244
               +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEY
Sbjct: 1182 DTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEY 1241

Query: 1245 ADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1304
            ADK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKS
Sbjct: 1242 ADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 1301

Query: 1305 LRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY 1364
            LRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 
Sbjct: 1302 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG 1361

Query: 1365 HCINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKG 1423
             CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQV     
Sbjct: 1362 RCINQTEGDLPLNYTIVNNKSQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQV----- 1415

Query: 1424 WMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF 1483
                          E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 
Sbjct: 1416 -------------YEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKL 1462

Query: 1484 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICL 1543
            GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICL
Sbjct: 1463 GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICL 1522

Query: 1544 NMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVI 1603
            NMVTMMVETDDQS E  NIL  INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVI
Sbjct: 1523 NMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVI 1582

Query: 1604 LSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663
            LSIVG  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNI
Sbjct: 1583 LSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNI 1642

Query: 1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPI 1723
            GLLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PI
Sbjct: 1643 GLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPI 1702

Query: 1724 LNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVAT 1783
            LN+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVAT
Sbjct: 1703 LNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVAT 1761

Query: 1784 EESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMD 1843
            EES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MD
Sbjct: 1762 EESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMD 1821

Query: 1844 LPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRK 1903
            LPMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK
Sbjct: 1822 LPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRK 1881

Query: 1904 QEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST-- 1959
             EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +  
Sbjct: 1882 HEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRP 1941

Query: 1960 --PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
              P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1942 LGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1982


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score = 2345 bits (6076), Expect = 0.0
 Identities = 1267/2080 (60%), Positives = 1502/2080 (72%), Gaps = 207/2080 (9%)

Query: 6    LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
            L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5    LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63   PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
            P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65   PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123  IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
            +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125  VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183  DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
             FTFLRDPWNWLDF+VI  AYV+E + LGN+SALRTFRVLRALKTISVIPGLKTIVGALI
Sbjct: 185  AFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALI 244

Query: 243  QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
            QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245  QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301  DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
            + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295  EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361  NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
            ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349  DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421  LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
            LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409  LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481  GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
               S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454  DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504

Query: 540  SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                         +  H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 505  -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600  TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
            T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550  TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659  GPSTLTSAGQLL--------PEGTTTETEI--RKRRSSSYHVSMDLLEDPTSRQRAMSIA 708
            G    TS G  L        P  TTT +E     +  +S    +D  E+P +RQRA+S  
Sbjct: 607  GDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAV 666

Query: 709  SILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITIC 768
            S+LT+ +EELEESR KCPPCW + A   LIW+CC  W+ +K  V LVVMDPF DL IT+C
Sbjct: 667  SVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMC 726

Query: 769  IVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDG 828
            IVLNTLFMA+EHY MT +F  +L VGNLVFTGIFTAEM  KIIA+DPYYYFQ+GWNIFD 
Sbjct: 727  IVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDS 786

Query: 829  FIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 888
             IV LSLMELGL+ +  LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVL
Sbjct: 787  IIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL 846

Query: 889  AIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMW 948
            AIIVFIFAVVGMQLFGK+Y E   + S+   LPRWHM DFFH+FLI+FR+LCGEWIETMW
Sbjct: 847  AIIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMW 904

Query: 949  DCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG 1008
            DCMEV+GQ++CL VF++VMVIGNLVVLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ 
Sbjct: 905  DCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALA 964

Query: 1009 RMQKGIDFVKRKIREF---IQKAFVRKQKALDEIKPLEDLNNKKDSCISN------HTTI 1059
            R+Q+G+ FVKR   +F   + +   +K  AL           +  SCI+         T 
Sbjct: 965  RIQRGLRFVKRTTWDFCCGLLRQRPQKPAAL-------AAQGQLPSCIATPYSPPPPETE 1017

Query: 1060 EIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFE---- 1115
            ++       +   G   G G+                 +P   V VPIAV ESD +    
Sbjct: 1018 KVPPTRKETRFEEGEQPGQGTP---------------GDPE-PVCVPIAVAESDTDDQEE 1061

Query: 1116 ----NLNTEEFSSESDME------------ESKEKLNATSSSEGST------------VD 1147
                +L TEE SS+ + +             +  +++AT+SSE                +
Sbjct: 1062 DEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAE 1121

Query: 1148 IGAPAEGEQPEVEPEES----------------------LEPEACFTEDCVRKFKCCQIS 1185
              AP  GE PE    E                        +PE CFTE CVR+  CC + 
Sbjct: 1122 PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVD 1181

Query: 1186 IEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYA 1245
              +  GK+WW LRKTCY IVEH+WFETFI+FMILLSSGALAFEDIY+E+RKTIK +LEYA
Sbjct: 1182 TTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYA 1241

Query: 1246 DKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSL 1305
            DK+FTY+F+LEMLLKWVAYGF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSL
Sbjct: 1242 DKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSL 1301

Query: 1306 RTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
            RTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  
Sbjct: 1302 RTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGR 1361

Query: 1366 CINYTTGEM-FDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGW 1424
            CIN T G++  + ++VNN S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGW
Sbjct: 1362 CINQTEGDLPLNYTIVNNKSQCESLNLTGE-LYWTKVKVNFDNVGAGYLALLQVATFKGW 1420

Query: 1425 MDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1484
            MDIMYAAVDSR  E QP++E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK G
Sbjct: 1421 MDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLG 1480

Query: 1485 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
            GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLN
Sbjct: 1481 GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLN 1540

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVIL 1604
            MVTMMVETDDQS E  NIL  INL+F+ +FT                             
Sbjct: 1541 MVTMMVETDDQSPEKINILAKINLLFVAIFT----------------------------- 1571

Query: 1605 SIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIG 1664
               G  L+++I+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIG
Sbjct: 1572 ---GTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIG 1628

Query: 1665 LLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPIL 1724
            LLLFLVMFIY+IFGM+NFAYVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PIL
Sbjct: 1629 LLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPIL 1688

Query: 1725 NSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATE 1784
            N+GPP CDP   +   S +GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATE
Sbjct: 1689 NTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATE 1747

Query: 1785 ESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDL 1844
            ES EPLSEDDF+MFYE+WEKFDP+ATQFIE++ LSDFADAL  PL IAKPN++ LI MDL
Sbjct: 1748 ESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDL 1807

Query: 1845 PMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQ 1904
            PMVSGDRIHC+DILFAFTKRVLGESGEMDAL+IQMEE+FMA+NPSK+SYEPITTTL+RK 
Sbjct: 1808 PMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKH 1867

Query: 1905 EEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKEC--DGTPIKEDTLIDKLNENST--- 1959
            EEVSA++IQRA+RR+LL++ +K  S ++++  G     +  P +E  +   ++EN +   
Sbjct: 1868 EEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPL 1927

Query: 1960 -PEKTDMTPSTTSPPSYDSVTKPEKEKFE---KDKSEKED 1995
             P  +    ST+ PPSYDSVT+   +  +    D S  ED
Sbjct: 1928 GPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSED 1967


>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
            sapiens]
          Length = 1956

 Score = 2118 bits (5488), Expect = 0.0
 Identities = 1144/2032 (56%), Positives = 1413/2032 (69%), Gaps = 179/2032 (8%)

Query: 12   DSFRFFTRESLAAIEQRIAEEKAKRPKQE--RKDEDDENGPKPNSDLEAGKSLPFIYGDI 69
            ++FR FT ESL  IE++IA ++  +  +E  R+ +D E  P+P  DL+A   LP  YG++
Sbjct: 11   NNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGEL 70

Query: 70   PPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHS 129
            P E++  PLEDLDP+Y   +TF+VLNKG+ ISRFSAT AL++ +PFN IR+ AIK+ VHS
Sbjct: 71   PAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHS 130

Query: 130  LFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRD 189
             F++ I  TIL NCV MT ++ P+    +EY FT IYTFE+LIKILARGFCL +FT+LRD
Sbjct: 131  WFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYLRD 187

Query: 190  PWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLS 249
            PWNWLDF+VIT AYV   +DL  +S LRTFRVLRALKT+SVIPGLK IVGALI SVKKL+
Sbjct: 188  PWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLA 247

Query: 250  DVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNR 309
            DV ILT+FCLSVFAL+GLQLF GNL+NKC++     +   +N T+ +++           
Sbjct: 248  DVTILTIFCLSVFALVGLQLFKGNLKNKCVK-----NDMAVNETTNYSSHRKP------- 295

Query: 310  TVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDT 369
                   D YI  +       G +D LLCGN SD+G CP+GYIC+K   NP++ YTSFD+
Sbjct: 296  -------DIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDS 341

Query: 370  FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429
            F+WAFLSLFRLMTQD WE LYQ TLR +GK YMIFFVLVIFLGSFYL+NLILAVV MAYE
Sbjct: 342  FAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYE 401

Query: 430  EQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSV 489
            EQNQAT +E E KE +FQ+ LE L+K+QE   A                GI   S  S  
Sbjct: 402  EQNQATTDEIEAKEKKFQEALEMLRKEQEVLAAL---------------GIDTTSLHSHN 446

Query: 490  ASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYE 549
             S L+SK+  E +  R K +  E S E+ K+ R                           
Sbjct: 447  GSPLTSKNASE-RRHRIKPRVSEGSTEDNKSPR--------------------------- 478

Query: 550  KRFSSPH-QSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFE-DNDSR 607
               S P+ Q  +S  G     RR S  S+F FR   +DI       DD    F  D++S 
Sbjct: 479  ---SDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDD--GVFPGDHESH 533

Query: 608  RDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAG 667
            R SL +    G+       Q       LP  P N       D +        P T     
Sbjct: 534  RGSLLLGGGAGQ-------QGPLPRSPLP-QPSNPDSRHGEDEHQP------PPT----S 575

Query: 668  QLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPP 727
            +L P G    +     +  ++ +S + L++P   QRAMS+ SI+T+ +EELEES QKCPP
Sbjct: 576  ELAP-GAVDVSAFDAGQKKTF-LSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPP 633

Query: 728  CWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQF 787
            C    +   LIWDCC  W+K+K ++  +V DPF +L IT+CIV+NT+FMAMEH+ M+  F
Sbjct: 634  CLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTF 693

Query: 788  SSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLS 847
             ++L +GN+VFT  FTAEM  KIIA DPYYYFQ+ WNIFD  IV++SL+ELG+A    LS
Sbjct: 694  EAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLS 753

Query: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
            VLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y
Sbjct: 754  VLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENY 813

Query: 908  KECVCKISNDCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
            +     IS   E  PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV  +++CL +F+ V
Sbjct: 814  RNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTV 873

Query: 967  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
            MV+GNLVVLNLF+ALLL+SFS+DNL A +DD E+NNLQ+A+ R+Q      K+ +  F  
Sbjct: 874  MVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFS 933

Query: 1027 KAFVRKQ-KALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKY 1085
            ++    Q KA  E+     L++ K     NH                 T  G    ++  
Sbjct: 934  RSCPFPQPKAEPELVVKLPLSSSK---AENHIAA-------------NTARGSSGGLQAP 977

Query: 1086 VVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-------------------------- 1119
                 ++  FI NP++ V+VPIA GESD ++L                            
Sbjct: 978  RGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVE 1037

Query: 1120 -------------------------EEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEG 1154
                                     E +  ES  +   E ++ TSSSEGSTVD   P E 
Sbjct: 1038 RCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEI 1097

Query: 1155 EQPEVEPEESL-EPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETF 1213
             +   E  + L EP+ CFTE C+R   CC++   +    + W +RKTCY+IVEH+WFE+F
Sbjct: 1098 LRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESF 1157

Query: 1214 IVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNA 1273
            I+FMILLSSG+LAFED Y++Q+ T+K +LEY D+VFT+IF+ EMLLKWVAYGF+ YFTNA
Sbjct: 1158 IIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNA 1217

Query: 1274 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGA 1333
            WCWLDFLIV++SL+SLTA  L YSE+  IK+LRTLRALRPLRALSRFEGMRVVV+AL+GA
Sbjct: 1218 WCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGA 1277

Query: 1334 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE--MFDVSVVNNYSECKALIE 1391
            IPSIMNVLLVCLIFWLIFSIMGVNLFAGKF+ CINYT GE  +  +S+VNN S+CK +  
Sbjct: 1278 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK-IQN 1336

Query: 1392 SNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYL 1451
            S  +  W NVKVNFDNV +GYL+LLQVATFKGWMDIMYAAVDSR V +QPK+EDN+YMYL
Sbjct: 1337 STGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYL 1396

Query: 1452 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
            YFVIFIIFG FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQK
Sbjct: 1397 YFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1456

Query: 1512 PIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFI 1571
            PIPRP NKFQG VFD VT+Q FDI+IM+LICLNM+TMMVETDDQS+E T IL  IN  F+
Sbjct: 1457 PIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFV 1516

Query: 1572 VLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIE--KYFVSPTLFRVIR 1629
             +FTGECV+K+ +LR YYFT GWN+FDF+VV+LSI  +  + +++  + + SPTLFRVIR
Sbjct: 1517 AVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIR 1576

Query: 1630 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1689
            LARIGRILRLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGMS+F +V+ E 
Sbjct: 1577 LARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEA 1636

Query: 1690 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNP 1749
            GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP+  +  +  +GDCG+P
Sbjct: 1637 GIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPN-SNGTRGDCGSP 1695

Query: 1750 SVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDA 1809
            +VGI FF +YIIISFL++VNMYIAVILENF+VATEES EPLSEDDF+MFYE WEKFDP+A
Sbjct: 1696 AVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEA 1755

Query: 1810 TQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES 1869
            TQFI F+ LSDFAD L  PL I KPN+  LI MDLP+V GD+IHCLDILFAFTK VLGES
Sbjct: 1756 TQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGES 1815

Query: 1870 GEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVS 1929
            GE+D+L+  MEE+FMA+N SK SYEPI TTL+ KQE++SA +IQ+AYR Y+L + +   +
Sbjct: 1816 GELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSN 1875

Query: 1930 SIYKKDKGKECDGTPIKEDTLIDKLNENST-PEKTDMTPSTTSPPSYDSVTK 1980
            +       +E    P  E  +    NEN   P+K++   +T+ PPSY+SVT+
Sbjct: 1876 TPCVPRAEEEAASLP-DEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926


>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
          Length = 1836

 Score = 1869 bits (4842), Expect = 0.0
 Identities = 938/1257 (74%), Positives = 1067/1257 (84%), Gaps = 19/1257 (1%)

Query: 711  LTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIV 770
            +++ MEELEE+ QKCPP WYK A+  LIW+CC PWLK K++++L+VMDPFVDL ITICIV
Sbjct: 530  ISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIV 589

Query: 771  LNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFI 830
            LNTLFMAMEHYPMTE F +VL+VGNLVFTGIFTAEM LK+IAMDPY YFQ+GWNIFD  I
Sbjct: 590  LNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSII 649

Query: 831  VSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
            V+LSL+ELGLANV+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI
Sbjct: 650  VTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709

Query: 891  IVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 950
            IVFIFAVVGMQLFGKSYKECVCKI+ DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDC
Sbjct: 710  IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDC 769

Query: 951  MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRM 1010
            MEVAGQ MCLTVF+MVMVIGNLVVLNLFLALLLSSFS+D+LAA+D+D EMNNLQIA+GR+
Sbjct: 770  MEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRI 829

Query: 1011 QKGIDFVKRKIREFIQKAFVRKQK---ALDEIKPLEDLNNKKDSCISNHTTIEIGKDL-- 1065
            + GI F K  +   +    +  +    +L E     +     ++   +       +DL  
Sbjct: 830  KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKK 889

Query: 1066 -NYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSS 1124
             N++ +  G   G  SS+      E D+++FINNP LT+ VPIA  ESD E    EE  +
Sbjct: 890  DNHILNHMGLADGPPSSL------ELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDT 943

Query: 1125 ESDMEESK---EKLNATSSSEGSTVDIGAPAEG--EQPEVEPEESLEPEACFTEDCVRKF 1179
             S+ E+SK   + L   +SS  ST D   P E   EQ E  PE   +PE CFTE CV+++
Sbjct: 944  FSEPEDSKKPPQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRW 1002

Query: 1180 KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIK 1239
             C  + I +G+GK WW LR+ C+KIVEHNWFETFIVFMILLSSGALAFEDIYIEQR+ I+
Sbjct: 1003 PCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIR 1062

Query: 1240 TMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSEL 1299
            T+LEYADKVFTYIFI+EMLLKWVAYGF+VYFTNAWCWLDFLIVDVS++SL AN LGYSEL
Sbjct: 1063 TILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSEL 1122

Query: 1300 GAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1359
            G IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF
Sbjct: 1123 GPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLF 1182

Query: 1360 AGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVA 1419
            AGKFY+CIN TT E FD+S VNN SEC++L+ + Q  RW NVKVN+DNVGLGYLSLLQVA
Sbjct: 1183 AGKFYYCINTTTSERFDISEVNNKSECESLMHTGQ-VRWLNVKVNYDNVGLGYLSLLQVA 1241

Query: 1420 TFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
            TFKGWMDIMYAAVDSR  E QP+YE NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1242 TFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1301

Query: 1480 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMI 1539
            KKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QGMV+D VTKQ FDI+IMI
Sbjct: 1302 KKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMI 1361

Query: 1540 LICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDF 1599
            LICLNMVTMMVETD+QSQ   +ILY IN++FI++FTGECVLK+++LR YYFT+GWNIFDF
Sbjct: 1362 LICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDF 1421

Query: 1600 VVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1659
            VVVILSIVG+ L++LI+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRTLLFALMMSLPA
Sbjct: 1422 VVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPA 1481

Query: 1660 LFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGL 1719
            LFNIGLLLFLVMFIY+IFGMSNFAYVK+E GIDDMFNFETFGNS+ICLF+ITTSAGWDGL
Sbjct: 1482 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL 1541

Query: 1720 LAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
            L PILNSGPPDCDP+ ++PG+SVKGDCGNPS+GI FF SYIIISFL+VVNMYIA+ILENF
Sbjct: 1542 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF 1601

Query: 1780 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL 1839
            +VATEES+EPL EDDFEMFYE WEKFDPDATQFI +++LSDF D L  PL IAKPNK++L
Sbjct: 1602 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL 1661

Query: 1840 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTT 1899
            I +DLPMV GD+IHCLDILFA TK VLG+SGEMDAL+  MEE+FMA+NPSKVSYEPITTT
Sbjct: 1662 ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTT 1721

Query: 1900 LKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNE 1956
            LKRK EEV AI IQRAYRR+LL++ +K+ S +Y+       D  P KE  L + +++
Sbjct: 1722 LKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLLANTMSK 1778



 Score =  699 bits (1804), Expect = 0.0
 Identities = 352/491 (71%), Positives = 407/491 (82%), Gaps = 21/491 (4%)

Query: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65
           LVP GP+  R FTRESLAAIEQR  EE+A R ++ ++ E +E   KP SDLEAGK+LP I
Sbjct: 9   LVPLGPECLRPFTRESLAAIEQRAVEEEA-RLQRNKQMEIEEPERKPRSDLEAGKNLPMI 67

Query: 66  YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKI 125
           YGD PPE++ +PLEDLDPYY NKKTFIVLNKGKAI RFSATPALY+L+PF+ +R+ AIK+
Sbjct: 68  YGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKV 127

Query: 126 LVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFT 185
           L+H+LF+M IM TILTNCVFMTMS+PP W+KNVEYTFTGIYTFESLIKILARGFC++DFT
Sbjct: 128 LIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVDDFT 187

Query: 186 FLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSV 245
           FLRDPWNWLDF+VI  AY+TEFVDLGN+SALRTFRVLRALKTI+VIPGLKTIVGALIQSV
Sbjct: 188 FLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSV 247

Query: 246 KKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSLD 301
           KKLSDVMILTVFCLSVFAL+GLQLFMGNLR KC++WPP     N+++  N T + N++  
Sbjct: 248 KKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWY 307

Query: 302 GN-----------GTTFN-----RTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG 345
           GN             T+N      T   F+WD YI D+ +FYFLEG NDALLCGNSSDAG
Sbjct: 308 GNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAG 367

Query: 346 QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFF 405
            CPEGY C+K GRNPNYGYTS+DTFSWAFL+LFRLMTQD+WENL+QLTLRAAGKTYMIFF
Sbjct: 368 HCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFF 427

Query: 406 VLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAA 465
           V++IFLGSFYLINLILAVVAMAY EQN+ATL E ++KE EFQQMLE+ KK QEE + A A
Sbjct: 428 VVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKA 487

Query: 466 AASAESRDFSG 476
           A + E  +  G
Sbjct: 488 AQALEGGEADG 498



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 78/340 (22%), Positives = 147/340 (43%), Gaps = 80/340 (23%)

Query: 118  IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNV-----EYT---FTGIYTFE 169
            +R+   KI+ H+ F   I+  IL +   +   +     + V     EY    FT I+  E
Sbjct: 1020 LRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIME 1079

Query: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSALRTFRVLR 223
             L+K +A GF +    +  + W WLDF ++  + ++       + +LG + +LRT R LR
Sbjct: 1080 MLLKWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALR 1135

Query: 224  ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP 283
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G     C+    
Sbjct: 1136 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-YYCI---- 1190

Query: 284  DNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSD 343
                               N TT  R    F+  E + +KS             C +   
Sbjct: 1191 -------------------NTTTSER----FDISE-VNNKSE------------CESLMH 1214

Query: 344  AGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK---- 399
             GQ    ++ VK          ++D     +LSL ++ T   W ++    + +  K    
Sbjct: 1215 TGQV--RWLNVK---------VNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP 1263

Query: 400  -----TYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
                  YM ++FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1264 QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1303



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 18/169 (10%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
            +R+   K++ H  F  FI+  IL +   +   D     +      +EY    FT I+  E
Sbjct: 120  VRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFE 171

Query: 1257 MLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
             L+K +A GF V    +  + W WLDF ++      + A    + +LG I +LRT R LR
Sbjct: 172  SLIKILARGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLR 225

Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
             L+ ++   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G
Sbjct: 226  ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 47/173 (27%), Positives = 86/173 (49%), Gaps = 12/173 (6%)

Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
           P+  V+     V++     + I I I+ N +FM M   P   +           FTGI+T
Sbjct: 116 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEY------TFTGIYT 169

Query: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
            E  +KI+A    +D + + ++ WN  D  ++ ++ +     ++  +S LR+FR+LR  K
Sbjct: 170 FESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGNISALRTFRVLRALK 228

Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911
                P L  ++  +  SV  L ++ ++    + +FA+VG+QLF G   ++CV
Sbjct: 229 TITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCV 281



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 48/175 (27%), Positives = 89/175 (50%), Gaps = 16/175 (9%)

Query: 114 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP--DWTKNV----EYTFTGIYT 167
           P+   + +   I++    ++ I   I+ N +FM M + P  +   NV       FTGI+T
Sbjct: 563 PWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFT 622

Query: 168 FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV---SALRTFRVLRA 224
            E ++K++A    ++ + + +  WN  D  ++T + V   + L NV   S LR+FR+LR 
Sbjct: 623 AEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVE--LGLANVQGLSVLRSFRLLRV 676

Query: 225 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279
            K     P L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +C+
Sbjct: 677 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730



 Score = 38.1 bits (87), Expect = 0.087
 Identities = 19/73 (26%), Positives = 44/73 (60%), Gaps = 2/73 (2%)

Query: 928 FFHSFLIVFRVLCGEWIETMWDC-MEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
           F  +FL +FR++  ++ E ++   +  AG+T  +  F++++ +G+  ++NL LA++  ++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMI-FFVVIIFLGSFYLINLILAVVAMAY 450

Query: 987 SSDNLAATDDDNE 999
           +  N A   +D E
Sbjct: 451 AEQNEATLAEDKE 463



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 23/100 (23%), Positives = 46/100 (46%), Gaps = 10/100 (10%)

Query: 1404 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFF 1463
            ++D     +L+L ++ T   W ++          +L  +     YM ++FV+ I  GSF+
Sbjct: 388  SYDTFSWAFLALFRLMTQDYWENLF---------QLTLRAAGKTYM-IFFVVIIFLGSFY 437

Query: 1464 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503
             +NL + V+   + +Q +    +D    EE ++     KK
Sbjct: 438  LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 16/69 (23%), Positives = 38/69 (55%)

Query: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYE 429
           F  +FL +FR++  ++ E ++     A     +  F++V+ +G+  ++NL LA++  ++ 
Sbjct: 747 FFHSFLIVFRILCGEWIETMWDCMEVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFS 806

Query: 430 EQNQATLEE 438
             + A  +E
Sbjct: 807 ADSLAASDE 815


>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
            sapiens]
          Length = 1682

 Score = 1343 bits (3475), Expect = 0.0
 Identities = 695/1292 (53%), Positives = 906/1292 (70%), Gaps = 40/1292 (3%)

Query: 667  GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCP 726
            G    E  T + E++KR   S   S+D+LED T R +            EELE+S++ CP
Sbjct: 425  GNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHK------------EELEKSKKICP 472

Query: 727  PCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQ 786
              WYKFA   LIW+C   WLK+K  V+ ++M PF DL + ICI+LN  F+ +EHYPM++Q
Sbjct: 473  LYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQ 532

Query: 787  FSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGL 846
             +++L++GNLVF GIFTAEM  KIIAM PY YFQ GWNIFD  IV   L+EL LANV G+
Sbjct: 533  TNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGM 592

Query: 847  SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 906
            ++LR FR+LR+FKL K WPT  +L+  + NS  AL +L L+L   +F  A  GM+LFGK+
Sbjct: 593  ALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKN 652

Query: 907  YKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMV 966
            Y+E VC I  DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+  ++MV
Sbjct: 653  YEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMV 712

Query: 967  MVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
            ++IGNL+VL LFLAL+ SSFSS      +++NE  NLQ+AV R++KGI++V  KI    Q
Sbjct: 713  ILIGNLLVLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQ 771

Query: 1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYV 1086
                     ++E+   ED        IS+HT  E+    ++LKD   +     S  EK  
Sbjct: 772  NVPKDTMDHVNEVYVKED--------ISDHTLSELSNTQDFLKDKEKS-----SGTEKNA 818

Query: 1087 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTV 1146
              E++  S I +PS++ TVPIA GESD ENL+ +E  S+S    SKEK+  +SSSE STV
Sbjct: 819  T-ENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTV 877

Query: 1147 DIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVE 1206
            DI A +E E+     E S          C R     QIS    KGK+W N+RKTC KIVE
Sbjct: 878  DI-AISEEEEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVE 932

Query: 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF 1266
            +NWF+ FI  + LLS+G LAFEDIY++QRKTIK +LEYAD +FTYIFILEMLLKW+AYGF
Sbjct: 933  NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF 992

Query: 1267 QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVV 1326
            + YF+N W  LDF++V V  +SL            +K L +++ LRPLR LS+FE M+VV
Sbjct: 993  KAYFSNGWYRLDFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVV 1047

Query: 1327 VNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSEC 1386
            V AL+      +NV LVCL+ WLIFSIMGV+LFAG+FY CI+ T+GE F  S V N S C
Sbjct: 1048 VRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRC 1107

Query: 1387 KALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDN 1446
            ++L+  N++  W+N K+NFDNVG G+LSLLQVATF GW+ IM +A+DS  V +QP +E N
Sbjct: 1108 ESLL-FNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVN 1166

Query: 1447 LYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            +YMY YF+ FIIFG F  L++ I VIIDNFN+ K K GG +IF+T +Q+K Y  +KKL  
Sbjct: 1167 IYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMY 1226

Query: 1507 KKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI 1566
            +  Q+P+PRP NK QG +FD VT Q F++ +M+LIC   + MM++TD QS +M+  LYWI
Sbjct: 1227 EDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWI 1286

Query: 1567 NLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFR 1626
            N +F++L+T EC+LKLI+ R +YFTI WNIFDF+VVI SI G+ L   +  Y V P+L +
Sbjct: 1287 NSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQ 1346

Query: 1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1686
            +I L+RI  +LRL KG K    L+  LM+SLPAL NI LL+FLVMFIYA+FGM NFAYVK
Sbjct: 1347 LILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK 1406

Query: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDC 1746
            +E GI+D+ NFETFGNSM+CLFQ+   AGWDG+L  I NS   DCDPDK +PG+ V+GDC
Sbjct: 1407 KEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDC 1466

Query: 1747 GNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFD 1806
            GNPSVGIF+FVSYI+IS+L++VNMYI V++E  ++A+++  + LSEDDF  F++VW++FD
Sbjct: 1467 GNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFD 1526

Query: 1807 PDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
            PD TQ+I+ +KLSDFA ALDPPL +AKPNK QLIA+DLPM  GDRIHCLDIL AFTKRV+
Sbjct: 1527 PDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVM 1586

Query: 1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVK 1926
            G+   M+ +  ++E  F+ +NP K++ EPITTTLKRKQE VSA IIQRAY+ Y L++  K
Sbjct: 1587 GQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDK 1646

Query: 1927 KVSSIYKKDKGKECDGTPIKEDTLIDKLNENS 1958
              S I+  D  ++   T  KE    DK  E S
Sbjct: 1647 NTSDIHMIDGDRDVHAT--KEGAYFDKAKEKS 1676



 Score =  422 bits (1086), Expect = e-117
 Identities = 224/469 (47%), Positives = 301/469 (64%), Gaps = 29/469 (6%)

Query: 5   VLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPF 64
           +L  P P     FT+ES   I+Q IA       K   +D ++E+  KP  DLE GK LPF
Sbjct: 1   MLASPEPKGLVPFTKESFELIKQHIA-------KTHNEDHEEED-LKPTPDLEVGKKLPF 52

Query: 65  IYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAI 123
           IYG++   MVS PLED+DPYY  KK TFIVLNK + I RF+A   L  L+PFN IR+  I
Sbjct: 53  IYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTI 112

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLED 183
           K+LVH  F + I+ ++L +CVFM+++N P W   +E T  GIYTFE L+K+ ARG     
Sbjct: 113 KVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGS 172

Query: 184 FTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
           F+FL DPWNWLDF+V  F  +  +  L  +  L+T R LR LK I +  GLK++VG LI 
Sbjct: 173 FSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIH 232

Query: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
            +K+L  V+ILT+F LS+F+LIG+ LFMGNL++KC +WP +N                 N
Sbjct: 233 CLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENE----------------N 276

Query: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
            T  NRT + +    YI +  +FY+LEG+  ALLCGN +DAGQCPEGY+CVKAG NP+ G
Sbjct: 277 ETLHNRTGNPY----YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQG 332

Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
           +T+FD+F WA  +LFRLM QD+ E LY   L A+GK YMIFFV+V FL SFY+ +L L +
Sbjct: 333 FTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGI 392

Query: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
           +AMAYEE+ Q   E +++ E +FQQ  ++L++  E  +A       + R
Sbjct: 393 LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKR 441



 Score =  144 bits (362), Expect = 1e-33
 Identities = 154/688 (22%), Positives = 294/688 (42%), Gaps = 142/688 (20%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
            +R+T  K++ H +F+ FI+  +L+    ++  ++   +     T+L     ++T+  +++
Sbjct: 107  IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162

Query: 1257 MLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRA 1316
            +  + V  G   +  + W WLDF +    ++      + YS L  I +L+T R LR L+ 
Sbjct: 163  LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216

Query: 1317 LSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH----------- 1365
            +   +G++ +V  L+  +  ++ V+++ L F  IFS++G+ LF G   H           
Sbjct: 217  IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276

Query: 1366 -CINYTTGEMFDVSVVNNY----SECKALIESNQTARWKNVK---------------VNF 1405
              ++  TG  + +    N+     E  AL+  N+T   +  +                NF
Sbjct: 277  ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336

Query: 1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTL 1465
            D+ G    +L ++   + + +++Y          Q  Y       ++FV+     SF+  
Sbjct: 337  DSFGWALFALFRLMA-QDYPEVLYH---------QILYASGKVYMIFFVVVSFLFSFYMA 386

Query: 1466 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1506
            +LF+G++   + ++K++ G                 Q+   T+E K     MKK      
Sbjct: 387  SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446

Query: 1507 ------------------KKPQKPIPRPANKF----------------QGMVFDFVTKQV 1532
                              +K +K  P    KF                +  V   +    
Sbjct: 447  DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506

Query: 1533 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLR-YYYFT 1591
             D+ ++I I LN+  + +E    S++   +L   NLVFI +FT E + K+I++  Y YF 
Sbjct: 507  TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566

Query: 1592 IGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1651
            +GWNIFD ++V   ++ + LA +            ++RL R+ RI +L K     + L++
Sbjct: 567  VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618

Query: 1652 ALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--YVKREVGID-----DMFNFETFGNSM 1704
            +L  S  AL ++ LLLF  +F  A FGM  F   Y +    ID       ++   F +S 
Sbjct: 619  SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678

Query: 1705 ICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISF 1764
            + +F+I      + L   +  +G   C P                     F++  I+I  
Sbjct: 679  LNVFRILCGEWVETLWDCMEVAGQSWCIP---------------------FYLMVILIGN 717

Query: 1765 LVVVNMYIAVILENFSVATEESAEPLSE 1792
            L+V+ +++A++  +FS   + +AE  +E
Sbjct: 718  LLVLYLFLALV-SSFSSCKDVTAEENNE 744



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 58/263 (22%), Positives = 120/263 (45%), Gaps = 26/263 (9%)

Query: 26  EQRIAEEKAK-RPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPY 84
           +QR+ E   K  PK ++  ++ + G    ++ +  K++        P      L+ L+  
Sbjct: 401 KQRVGEISKKIEPKFQQTGKELQEG----NETDEAKTIQIEMKKRSPISTDTSLDVLEDA 456

Query: 85  YINKKTFIVLNKGKAIS-----RFSATPALYILTP-FNPIRKLAIKILVHSLFNMLIMCT 138
            +  K    L K K I      +F+ T  ++  +P +  +++   +I++    ++ ++  
Sbjct: 457 TLRHKE--ELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIIC 514

Query: 139 ILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWN 192
           I+ N  F+T+ + P     +   N+    F GI+T E + KI+A    +  + + +  WN
Sbjct: 515 IILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWN 570

Query: 193 WLDFTVITFAYVTE--FVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSD 250
             D ++I F  + E    ++  ++ LR FR+LR  K     P  + ++ +L  S   L D
Sbjct: 571 IFD-SMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKD 629

Query: 251 VMILTVFCLSVFALIGLQLFMGN 273
           +++L    +   A  G++LF  N
Sbjct: 630 LVLLLFTFIFFSAAFGMKLFGKN 652



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 13/164 (7%)

Query: 118  IRKLAIKILVHSLFNMLI-MCTILTNCVFMTMSNPPDWTKNV----EYT---FTGIYTFE 169
            IRK   KI+ ++ F   I + T+L+           D  K +    EY    FT I+  E
Sbjct: 923  IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982

Query: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTV-ITFAYVTEFVDLGNVSALRTFRVLRALKTI 228
             L+K +A GF      +  + W  LDF V I F           +  L + + LR L+ +
Sbjct: 983  MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038

Query: 229  SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            S    +K +V ALI++     +V ++ +    +F+++G+ LF G
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAG 1082



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 38/164 (23%), Positives = 84/164 (51%), Gaps = 11/164 (6%)

Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
           P+  ++     V++ PF  L I I ++++ +FM++ + P   ++  VL    L   GI+T
Sbjct: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLP---KWRPVLENTLL---GIYT 156

Query: 804 AEMFLKIIAMD----PYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
            E+ +K+ A       + +  + WN  D F V++  + +  + ++ +  L++ R LR+ K
Sbjct: 157 FEILVKLFARGVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILK 215

Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
           +      L  L+ ++ + +  L  + ++    + IF+++GM LF
Sbjct: 216 IIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLF 259



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 44/170 (25%), Positives = 78/170 (45%), Gaps = 29/170 (17%)

Query: 370 FSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMI-FFVLVIFLGSFYLINLILAVVA--- 425
           F  +FL++FR++  ++ E L+   +  AG+++ I F+++VI +G+  ++ L LA+V+   
Sbjct: 674 FFHSFLNVFRILCGEWVETLWDC-MEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFS 732

Query: 426 ----MAYEEQNQA---TLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAG 478
               +  EE N+A    L  A  K+     +L+ L K Q            ++ D     
Sbjct: 733 SCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQN--------VPKDTMD----- 779

Query: 479 GIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSES 528
                     V   +S  +  EL N +   K KE+S   EKN    +S+S
Sbjct: 780 ----HVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQS 825



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 36/175 (20%), Positives = 71/175 (40%), Gaps = 26/175 (14%)

Query: 114  PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFM---------TMSNPPDWTKNVEYTFTG 164
            P N ++     ++    FN+++M  I    + M          MS    W  ++   F  
Sbjct: 1236 PLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI---FVM 1292

Query: 165  IYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSA 215
            +YT E ++K++A  F    FT     WN  DF V+ F+           +  V    V  
Sbjct: 1293 LYTMECILKLIA--FRCFYFTI---AWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQL 1347

Query: 216  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
            +   R++  L+          ++  L+ S+  L ++++L    + ++A+ G+  F
Sbjct: 1348 ILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNF 1402


>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
            sapiens]
          Length = 1791

 Score = 1302 bits (3370), Expect = 0.0
 Identities = 704/1334 (52%), Positives = 929/1334 (69%), Gaps = 98/1334 (7%)

Query: 663  LTSAGQLLPEGTTTETEIRKR-------RSSSYHVSMDLLE---DPTSRQRAMSIASILT 712
            L  +G+  P G+ ++ + +K+       +  S ++S+D  +   DP  RQRA+S  SILT
Sbjct: 471  LRESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILT 530

Query: 713  NTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLN 772
             TM+E E+S++ C PC    A+  L+W+CC  WL VK ++  V+ DPF +LAITICI++N
Sbjct: 531  ITMKEQEKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIIN 590

Query: 773  TLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVS 832
            T+F+AMEH+ M   F  +L++GNLVFT IF AEM LKIIA+DPY+YF+ GWNIFD  +  
Sbjct: 591  TVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVAL 650

Query: 833  LSLMELGLANVEGLS--VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 890
            LS  ++    ++  S   LRSFR+LRVFKLAKSWPTLN LIKIIGNSVGALG+LT+VL I
Sbjct: 651  LSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVI 710

Query: 891  IVFIFAVVGMQLFGKSYKECVC-KISNDCE-----LPRWHMHDFFHSFLIVFRVLCGEWI 944
            ++FIF+VVGMQLFG+S+      K+ N        L  WHM DF+HSFL+VFR+LCGEWI
Sbjct: 711  VIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWI 770

Query: 945  ETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMN 1001
            E MW+CM+ A    ++C+ VF+++ VIG LVVLNLF+ALLL+SFS++      + +    
Sbjct: 771  ENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKT 830

Query: 1002 NLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEI 1061
             +Q+A+ R ++   FV+  +  F  K + RKQ        L         C +     +I
Sbjct: 831  KVQLALDRFRRAFCFVRHTLEHFCHK-WCRKQN-------LPQQKEVAGGCAAQSK--DI 880

Query: 1062 GKDLNYLKDGNGTTSGIG--SSVEKYV------------VDESDYMSFINNPSLT-VTVP 1106
               +  +K G+ T   +G  +SV K +             +E D + F    +   +T P
Sbjct: 881  IPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQP 940

Query: 1107 IAVGES-------------DFENLNTEEFSSESD---MEESKEKLNATSS-SEGSTVDIG 1149
                ++               +++  + FS +     +++ ++K + TS  SE ST+D+ 
Sbjct: 941  EPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDL- 999

Query: 1150 APAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNW 1209
                G  PE+ P++  +PE C  +     F CC +   +    +WWNLRKTCY+IV+H+W
Sbjct: 1000 QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSW 1057

Query: 1210 FETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVY 1269
            FE+FI+F+ILLSSGAL FED+++E +  I+ +L   D +FT+IFILEM+LKWVA+GF  Y
Sbjct: 1058 FESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKY 1117

Query: 1270 FTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNA 1329
            FT+AWC LDF+IV VS+ +L         L  +KS RTLRALRPLRALS+FEGM+VVVNA
Sbjct: 1118 FTSAWCCLDFIIVIVSVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNA 1170

Query: 1330 LLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL 1389
            L+GAIP+I+NVLLVCLIFWL+F I+GV  F+GKF  CIN  T  + + +++ N S+C++ 
Sbjct: 1171 LIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFGKCIN-GTDSVINYTIITNKSQCES- 1228

Query: 1390 IESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYM 1449
                    W N KVNFDNVG  YL+LLQVATFKGWMDI+YAAVDS   E QP++E N   
Sbjct: 1229 ----GNFSWINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLG 1284

Query: 1450 YLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1509
            Y+YFV+FIIFGSFFTLNLFIGVIIDNFNQQ+KK GGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1285 YIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKP 1344

Query: 1510 QKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
            QKPIPRP NK QG+VFD VT Q+FDI I+ LI LNM++MM E+ +Q + M +IL  +N V
Sbjct: 1345 QKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWV 1404

Query: 1570 FIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFV--SPTLFRV 1627
            F+V+FT EC++K+ +LR YYFT GWN+FD VVV+LSIV   ++ L  +  +   PTLFR+
Sbjct: 1405 FVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRI 1464

Query: 1628 IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
            +RLARIGRILRL++ A+GIRTLLFALMMSLP+LFNIGLLLFL+MFIYAI GM+ F+ V  
Sbjct: 1465 VRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNP 1524

Query: 1688 EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCG 1747
            E GIDD+FNF+TF +SM+CLFQI+TSAGWD LL+P+L S        K+   SS + +C 
Sbjct: 1525 ESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRS--------KESCNSSSE-NCH 1575

Query: 1748 NPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDP 1807
             P +   +FVSYIIISFL+VVNMYIAVILENF+ ATEES +PL EDDF++FYEVWEKFDP
Sbjct: 1576 LPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDP 1635

Query: 1808 DATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1867
            +ATQFI+++ LSDFADAL  PL +AKPNK Q + MDLPMVS DR+HC+DILFAFT RVLG
Sbjct: 1636 EATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLG 1695

Query: 1868 ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKK 1927
             S  +D+++  MEE+FM +NP K  YEPI TT KRK+EE  A IIQ+A+R+Y++K     
Sbjct: 1696 GSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMMK----- 1750

Query: 1928 VSSIYKKDKGKECD 1941
               + K D+G + D
Sbjct: 1751 ---VTKGDQGDQND 1761



 Score =  406 bits (1044), Expect = e-113
 Identities = 243/532 (45%), Positives = 317/532 (59%), Gaps = 56/532 (10%)

Query: 9   PGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGD 68
           P   +FR FT +SLAAIE+RIA +K K+  +++  E  +  P+P  DL+A + LP +YGD
Sbjct: 11  PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQ--PRPQLDLKASRKLPKLYGD 68

Query: 69  IPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVH 128
           IP E++  PLEDLDP+Y N KTF+VLN+ + I RFSA  AL+I  PFN IR LAI++ VH
Sbjct: 69  IPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVH 128

Query: 129 SLFNMLIMCTILTNCVFMTMSNPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDF 184
           SLF+M I+ T++ NCVFM      +   N     E  FTGIY FE+LIKILARGF L++F
Sbjct: 129 SLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEF 188

Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRALKTISVIPGLKTIVGALIQ 243
           +FLRDPWNWLD  VI  A V+    +   +  LRTFRV RALK ISV+  LK IVGAL++
Sbjct: 189 SFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLR 248

Query: 244 SVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGN 303
           SVKKL +V+ILT FCLS+FAL+G QLFMG+L  KC+     N S                
Sbjct: 249 SVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNIS---------------- 292

Query: 304 GTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYG 363
                   +   +D   E K      E   +  +CG       C   Y C     NP+Y 
Sbjct: 293 --------NPEAYDHCFEKK------ENSPEFKMCGIWMGNSACSIQYECKHTKINPDYN 338

Query: 364 YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAV 423
           YT+FD F W+FL++FRLMTQD WE LYQ TLR  G   + FF++VIFLGSFYLINL LAV
Sbjct: 339 YTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398

Query: 424 VAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVF 483
           V MAYEEQN+    E E KE  FQ+  +QL K+++EA  A               GI   
Sbjct: 399 VTMAYEEQNKNVAAEIEAKEKMFQE-AQQLLKEEKEALVAM--------------GIDRS 443

Query: 484 SESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRK 535
           S +S   S  + K  K   N+++K     +SG+    D+   S+S++  ++K
Sbjct: 444 SLTSLETSYFTPKKRKLFGNKKRKSFFLRESGK----DQPPGSDSDEDCQKK 491



 Score =  115 bits (287), Expect = 6e-25
 Identities = 158/799 (19%), Positives = 308/799 (38%), Gaps = 154/799 (19%)

Query: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
            P+  ++ L   V +     + I   +++N +FMA    P     S+   +   VFTGI+ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATG--PAKNSNSNNTDIAECVFTGIYI 171

Query: 804  AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
             E  +KI+A    +D + + ++ WN  D  ++ ++++         L  LR+FR+ R  K
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALK 231

Query: 860  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF---------------- 903
                   L +++  +  SV  L N+ ++    + IFA+VG QLF                
Sbjct: 232  AISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 291

Query: 904  --GKSYKEC--------------------VCKISNDCELPR-------WHMHDFFHSFLI 934
               ++Y  C                     C I  +C+  +        +  +F  SFL 
Sbjct: 292  SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLA 351

Query: 935  VFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT 994
            +FR++  +  E ++           +  F++V+ +G+  ++NL LA++  ++   N    
Sbjct: 352  MFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQN---- 407

Query: 995  DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI-----KPLEDLNNKK 1049
               N    ++      Q+    +K +    +     R      E      K  +   NKK
Sbjct: 408  --KNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKK 465

Query: 1050 DSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAV 1109
                 +    E GKD        G+ S      +  +++++  +S               
Sbjct: 466  R---KSFFLRESGKD-----QPPGSDSDEDCQKKPQLLEQTKRLS--------------- 502

Query: 1110 GESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEA 1169
                 +NL+ + F    D  + +  L+A S     T+ +           E E+S EP  
Sbjct: 503  -----QNLSLDHFDEHGDPLQRQRALSAVSI---LTITM----------KEQEKSQEPCL 544

Query: 1170 CFTEDCVRKF---KCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
               E+   K+    CC           W  ++K    ++   + E  I   I++++  LA
Sbjct: 545  PCGENLASKYLVWNCC---------PQWLCVKKVLRTVMTDPFTELAITICIIINTVFLA 595

Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSL 1286
             E  + +   + + ML   + VFT IFI EM LK +A     YF   W   D ++  +S 
Sbjct: 596  ME--HHKMEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSF 653

Query: 1287 VSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
              +    L       ++S R LR  +  ++      +  ++   +GA+ S + V+LV +I
Sbjct: 654  ADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGS-LTVVLVIVI 712

Query: 1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTA----RWKNVK 1402
            F  IFS++G+ LF   F                 N+    K    +  T      W    
Sbjct: 713  F--IFSVVGMQLFGRSF-----------------NSQKSPKLCNPTGPTVSCLRHW---- 749

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
             +  +    +L + ++   + W++ M+  +   N         +    + F++  + G  
Sbjct: 750  -HMGDFWHSFLVVFRILCGE-WIENMWECMQEANA-------SSSLCVIVFILITVIGKL 800

Query: 1463 FTLNLFIGVIIDNFNQQKK 1481
              LNLFI +++++F+ +++
Sbjct: 801  VVLNLFIALLLNSFSNEER 819



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/338 (23%), Positives = 147/338 (43%), Gaps = 47/338 (13%)

Query: 1196 NLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFIL 1255
            ++R    ++  H+ F  FI+  ++++   +A        + +     + A+ VFT I+I 
Sbjct: 117  SIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIF 172

Query: 1256 EMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRAL 1311
            E L+K +A GF +    +  + W WLD +++ +++VS             +  LRT R  
Sbjct: 173  EALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVF 227

Query: 1312 RPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF------YH 1365
            R L+A+S    ++V+V ALL ++  ++NV+++      IF+++G  LF G          
Sbjct: 228  RALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD 287

Query: 1366 CINYTTGEMFD--------------VSVVNNYSECKALIESNQTARWKNVK-VNFDNVGL 1410
            C N +  E +D                +    S C    E   T    +    NFDN G 
Sbjct: 288  CKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGW 347

Query: 1411 GYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470
             +L++ ++ T   W            +  Q      LY   +F++ I  GSF+ +NL + 
Sbjct: 348  SFLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLA 397

Query: 1471 VIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1508
            V+   + +Q K    +   +  ++K +  A + L  +K
Sbjct: 398  VVTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 79/334 (23%), Positives = 137/334 (41%), Gaps = 80/334 (23%)

Query: 118  IRKLAIKILVHSLFNMLIMCTILTNC---VF--MTMSNPPDWTKNVEYT---FTGIYTFE 169
            +RK   +I+ HS F   I+  IL +    +F  + + N P   + +  T   FT I+  E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104

Query: 170  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTIS 229
             ++K +A GF      +    W  LDF +I    VT  ++L  + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDF-IIVIVSVTTLINLMELKSFRTLRALRPLRALS 1159

Query: 230  VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFE 289
               G+K +V ALI ++  + +V+++ +    VF ++G+  F G    KC+    + +   
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI----NGTDSV 1214

Query: 290  INITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPE 349
            IN T   N S   +G         F+W   I  K +F                       
Sbjct: 1215 INYTIITNKSQCESGN--------FSW---INQKVNF----------------------- 1240

Query: 350  GYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM------- 402
                              D    A+L+L ++ T   W ++    + +  K          
Sbjct: 1241 ------------------DNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNS 1282

Query: 403  ---IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
               I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1283 LGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQK 1316



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 22/184 (11%)

Query: 104  SATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPDWTKNV--- 158
            S  P   I  P N  + L   I+   +F+++I+  I+ N + M     N P   K++   
Sbjct: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400

Query: 159  -EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD-LGN---- 212
              + F  I+T E LIKI    F L  + F  + WN  D  V+  + V+  +  L N    
Sbjct: 1401 LNWVFVVIFTLECLIKI----FALRQYYF-TNGWNLFDCVVVLLSIVSTMISTLENQEHI 1455

Query: 213  ------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIG 266
                     +R  R+ R L+ +    G++T++ AL+ S+  L ++ +L    + ++A++G
Sbjct: 1456 PFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILG 1515

Query: 267  LQLF 270
            +  F
Sbjct: 1516 MNWF 1519



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 45/162 (27%), Positives = 78/162 (48%), Gaps = 13/162 (8%)

Query: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP-----DWTKNV-EYTFTGIYTFESL 171
           ++K+   ++      + I   I+ N VF+ M +       +   N+    FT I+  E  
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625

Query: 172 IKILARGFCLEDFTFLRDPWNWLDFTV--ITFAYVTEFV-DLGNVSALRTFRVLRALKTI 228
           +KI+A    L+ + + R  WN  D  V  ++FA V   V    +   LR+FRVLR  K  
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681

Query: 229 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
              P L T++  +  SV  L  + ++ V  + +F+++G+QLF
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLF 723



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 67/368 (18%), Positives = 131/368 (35%), Gaps = 97/368 (26%)

Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFT 1575
            P N  + +        +F + I+  + +N V M   T       +N       VF  ++ 
Sbjct: 114  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMA--TGPAKNSNSNNTDIAECVFTGIYI 171

Query: 1576 GECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRL 1630
             E ++K+++       + +    WN  D +V+ ++IV       I+           +R 
Sbjct: 172  FEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK--------LLPLRT 223

Query: 1631 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS------NFAY 1684
             R+ R L+ I     ++ ++ AL+ S+  L N+ +L F  + I+A+ G        N   
Sbjct: 224  FRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKC 283

Query: 1685 VKREV-------GIDDMF---------------------------------------NFE 1698
            + R+          D  F                                       NF+
Sbjct: 284  ISRDCKNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFD 343

Query: 1699 TFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVS 1758
             FG S + +F++ T   W+ L    L +                          +FFF+ 
Sbjct: 344  NFGWSFLAMFRLMTQDSWEKLYQQTLRT---------------------TGLYSVFFFIV 382

Query: 1759 YIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKL 1818
             I +    ++N+ +AV+    ++A EE  + ++ +      E  EK   +A Q ++  K 
Sbjct: 383  VIFLGSFYLINLTLAVV----TMAYEEQNKNVAAE-----IEAKEKMFQEAQQLLKEEKE 433

Query: 1819 SDFADALD 1826
            +  A  +D
Sbjct: 434  ALVAMGID 441



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 19/88 (21%), Positives = 49/88 (55%), Gaps = 2/88 (2%)

Query: 370 FSWAFLSLFRLMTQDFWENLYQLT--LRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMA 427
           F  +FL +FR++  ++ EN+++      A+    +I F+L+  +G   ++NL +A++  +
Sbjct: 754 FWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIALLLNS 813

Query: 428 YEEQNQATLEEAEQKEAEFQQMLEQLKK 455
           +  + +    E E ++ + Q  L++ ++
Sbjct: 814 FSNEERNGNLEGEARKTKVQLALDRFRR 841



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 27/122 (22%)

Query: 359  NPNYGYT---SFDTFSWAFLSLFRLMTQDFWENLYQLTLRA---------------AGKT 400
            NP  G     +F TF+ + L LF++ T   W++L    LR+                  +
Sbjct: 1523 NPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCNSSSENCHLPGIATS 1582

Query: 401  YMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK--EAEFQQMLEQLKKQQE 458
            Y + ++++ FL    ++N+ +AV+    E  N AT EE+E    E +F    E  +K   
Sbjct: 1583 YFVSYIIISFL---IVVNMYIAVI---LENFNTAT-EESEDPLGEDDFDIFYEVWEKFDP 1635

Query: 459  EA 460
            EA
Sbjct: 1636 EA 1637


>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
            type V, alpha (long QT syndrome 3) [Homo sapiens]
          Length = 1637

 Score = 1018 bits (2632), Expect = 0.0
 Identities = 544/853 (63%), Positives = 633/853 (74%), Gaps = 72/853 (8%)

Query: 974  VLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREF---IQKAFV 1030
            VLNLFLALLLSSFS+DNL A D+D EMNNLQ+A+ R+Q+G+ FVKR   +F   + +   
Sbjct: 631  VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690

Query: 1031 RKQKALDEIKPLEDLNNKKDSCISNH------TTIEIGKDLNYLKDGNGTTSGIGSSVEK 1084
            +K  AL           +  SCI+         T ++       +   G   G G+    
Sbjct: 691  QKPAALAA-------QGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTP--- 740

Query: 1085 YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGS 1144
                         +P   V VPIAV ESD ++   +E +S    EES ++  +   S G 
Sbjct: 741  ------------GDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGG- 786

Query: 1145 TVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI 1204
                        PE  P+     +   T          + S  +   +  W         
Sbjct: 787  ------------PEAPPDSRTWSQVSATASSE-----AEASASQADWRQQWKAEPQAPGC 829

Query: 1205 VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAY 1264
             E                   AFEDIY+E+RKTIK +LEYADK+FTY+F+LEMLLKWVAY
Sbjct: 830  GE-------------------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAY 870

Query: 1265 GFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1324
            GF+ YFTNAWCWLDFLIVDVSLVSL AN LG++E+G IKSLRTLRALRPLRALSRFEGMR
Sbjct: 871  GFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMR 930

Query: 1325 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEM-FDVSVVNNY 1383
            VVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF  CIN T G++  + ++VNN 
Sbjct: 931  VVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNK 990

Query: 1384 SECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKY 1443
            S+C++L  + +   W  VKVNFDNVG GYL+LLQVATFKGWMDIMYAAVDSR  E QP++
Sbjct: 991  SQCESLNLTGELY-WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQW 1049

Query: 1444 EDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1503
            E NLYMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKK
Sbjct: 1050 EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKK 1109

Query: 1504 LGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNIL 1563
            LGSKKPQKPIPRP NK+QG +FD VTKQ FD++IM LICLNMVTMMVETDDQS E  NIL
Sbjct: 1110 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1169

Query: 1564 YWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPT 1623
              INL+F+ +FTGEC++KL +LR+YYFT  WNIFDFVVVILSIVG  L+++I+KYF SPT
Sbjct: 1170 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPT 1229

Query: 1624 LFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA 1683
            LFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY+IFGM+NFA
Sbjct: 1230 LFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1289

Query: 1684 YVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVK 1743
            YVK E GIDDMFNF+TF NSM+CLFQITTSAGWDGLL+PILN+GPP CDP   +   S +
Sbjct: 1290 YVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-R 1348

Query: 1744 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803
            GDCG+P+VGI FF +YIIISFL+VVNMYIA+ILENFSVATEES EPLSEDDF+MFYE+WE
Sbjct: 1349 GDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWE 1408

Query: 1804 KFDPDATQFIEFA 1816
            KFDP+ATQFIE++
Sbjct: 1409 KFDPEATQFIEYS 1421



 Score =  683 bits (1763), Expect = 0.0
 Identities = 384/672 (57%), Positives = 462/672 (68%), Gaps = 65/672 (9%)

Query: 6   LVPPGPDSFRFFTRESLAAIEQRIAEEKAKRP---KQERKDEDDENGPKPNSDLEAGKSL 62
           L+P G  SFR FTRESLAAIE+R+AE++A+     ++ R+   +E  P+P  DL+A K L
Sbjct: 5   LLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKL 64

Query: 63  PFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLA 122
           P +YG+ P E++  PLEDLDP+Y  +KTFIVLNKGK I RFSAT ALY+L+PF+PIR+ A
Sbjct: 65  PDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAA 124

Query: 123 IKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLE 182
           +KILVHSLFNMLIMCTILTNCVFM   +PP WTK VEYTFT IYTFESL+KILARGFCL 
Sbjct: 125 VKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLH 184

Query: 183 DFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
            FTFLRDPWNWLDF+VI  AY TEFVDLGNVSALRTFRVLRALKTISVI GLKTIVGALI
Sbjct: 185 AFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALI 244

Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSF--FNNSL 300
           QSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KC++          N T+    N S+
Sbjct: 245 QSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR----------NFTALNGTNGSV 294

Query: 301 DGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNP 360
           + +G  +       + D Y+ D  ++    G +D LLCGNSSDAG CPEGY C+KAG NP
Sbjct: 295 EADGLVWE------SLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENP 348

Query: 361 NYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLI 420
           ++GYTSFD+F+WAFL+LFRLMTQD WE LYQ TLR+AGK YMIFF+LVIFLGSFYL+NLI
Sbjct: 349 DHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLI 408

Query: 421 LAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
           LAVVAMAYEEQNQAT+ E E+KE  FQ+ +E LKK+ E                    G+
Sbjct: 409 LAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR---------------GV 453

Query: 481 GVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE-KNDRVRKSESEDSIRRKGFRF 539
              S SS   S L+  +  E   RR K++++  SG EE   DR+ KS+SED  R      
Sbjct: 454 DTVSRSSLEMSPLAPVNSHE---RRSKRRKRMSSGTEECGEDRLPKSDSEDGPR------ 504

Query: 540 SLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHS 599
                        +  H SL           R+SR S+F+FR R  D+GSE DFADDE+S
Sbjct: 505 -------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFRRR--DLGSEADFADDENS 549

Query: 600 TFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG- 658
           T  +++S   SL VP     RR S   Q S  +   P   ++GK +S VDCNGVVSL+G 
Sbjct: 550 TAGESESHHTSLLVP--WPLRRTSAQGQPSPGTSA-PGHALHGKKNSTVDCNGVVSLLGA 606

Query: 659 GPSTLTSAGQLL 670
           G    TS G  L
Sbjct: 607 GDPEATSPGSHL 618



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 83/350 (23%), Positives = 155/350 (44%), Gaps = 70/350 (20%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILE 1256
            +R+   KI+ H+ F   I+  IL +   +A  D             +Y +  FT I+  E
Sbjct: 120  IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171

Query: 1257 MLLKWVAYGFQVY-FT---NAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
             L+K +A GF ++ FT   + W WLDF ++      + A    + +LG + +LRT R LR
Sbjct: 172  SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225

Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH------- 1365
             L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   H       
Sbjct: 226  ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285

Query: 1366 CINYTTGEM--------------------------FDVSVVNNYSECKALIESNQTARW- 1398
             +N T G +                           DV +  N S+     E  +  +  
Sbjct: 286  ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345

Query: 1399 ---KNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVI 1455
                +   +FD+    +L+L ++ T   W  +    + S            +YM ++F++
Sbjct: 346  ENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG---------KIYM-IFFML 395

Query: 1456 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1504
             I  GSF+ +NL + V+   + +Q +      I  TEE +K++  AM+ L
Sbjct: 396  VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 69/285 (24%), Positives = 134/285 (47%), Gaps = 40/285 (14%)

Query: 743  KPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
            +P  K +  +  +V     D+ I   I LN + M +E    + +  ++L+  NL+F  IF
Sbjct: 1121 RPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIF 1180

Query: 803  TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANV--------EGLSVLRSFRL 854
            T E  +K+ A+  +YYF   WNIFD  +V LS++   L+++            V+R  R+
Sbjct: 1181 TGECIVKLAAL-RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239

Query: 855  LRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
             R+ +L +    +  L+  +  S+ AL N+ L+L +++FI+++ GM  F  +Y +    I
Sbjct: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGI 1297

Query: 915  SNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMC--------------- 959
             +      ++   F +S L +F++      + +   +   G   C               
Sbjct: 1298 DD-----MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCG 1352

Query: 960  -----LTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNE 999
                 +  F   ++I  L+V+N+++A++L +FS     AT++  E
Sbjct: 1353 SPAVGILFFTTYIIISFLIVVNMYIAIILENFS----VATEESTE 1393



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 71/288 (24%)

Query: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT------EFVDLGNVSA 215
            FT ++  E L+K +A GF      +  + W WLDF ++  + V+       F ++G + +
Sbjct: 855  FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910

Query: 216  LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
            LRT R LR L+ +S   G++ +V AL+ ++  + +V+++ +    +F+++G+ LF G   
Sbjct: 911  LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969

Query: 276  NKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA 335
             +C+          +N T   N S      + N T  ++ W +                 
Sbjct: 970  GRCIN--QTEGDLPLNYTIVNNKS---QCESLNLTGELY-WTK----------------- 1006

Query: 336  LLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR 395
                              VK          +FD     +L+L ++ T   W ++    + 
Sbjct: 1007 ------------------VK---------VNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1039

Query: 396  AAG---------KTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQ 433
            + G           YM I+FV+ I  GSF+ +NL + V+   + +Q +
Sbjct: 1040 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 58/284 (20%), Positives = 118/284 (41%), Gaps = 48/284 (16%)

Query: 790  VLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----GLANVE 844
            +L   + +FT +F  EM LK +A     YF   W   D  IV +SL+ L     G A + 
Sbjct: 847  LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906

Query: 845  GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 904
             +  LR+ R LR  +    +  + +++  +  ++ ++ N+ LV  I   IF+++G+ LF 
Sbjct: 907  PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966

Query: 905  KSYKECVCKISNDCEL------------------------PRWHMHDFFHSFLIVFRVLC 940
              +  C+ +   D  L                         + +  +    +L + +V  
Sbjct: 967  GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026

Query: 941  GE-WIETMWDCMEVAG---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS--- 987
             + W++ M+  ++  G                F++ ++ G+   LNLF+ +++ +F+   
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1086

Query: 988  ----SDNLAATDDDNEMNNLQIAVG--RMQKGIDFVKRKIREFI 1025
                  ++  T++  +  N    +G  + QK I     K + FI
Sbjct: 1087 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1130



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 42/173 (24%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 744 PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFT 803
           P+  ++     +++    ++ I   I+ N +FMA    P   ++          FT I+T
Sbjct: 116 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEY------TFTAIYT 169

Query: 804 AEMFLKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859
            E  +KI+A    +  + + ++ WN  D F V +        ++  +S LR+FR+LR  K
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGNVSALRTFRVLRALK 228

Query: 860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 911
                  L  ++  +  SV  L ++ ++    + +FA++G+QLF G    +CV
Sbjct: 229 TISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV 281



 Score = 38.5 bits (88), Expect = 0.067
 Identities = 24/120 (20%), Positives = 57/120 (47%), Gaps = 6/120 (5%)

Query: 928  FFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
            F  +FL +FR++  +  E ++     +   + +  FM+V+ +G+  ++NL LA++  ++ 
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 988  SDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNN 1047
              N A   +  E         R Q+ ++ +K++      +      ++  E+ PL  +N+
Sbjct: 418  EQNQATIAETEEKEK------RFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNS 471


>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform c [Homo sapiens]
          Length = 2137

 Score =  426 bits (1095), Expect = e-118
 Identities = 332/1146 (28%), Positives = 555/1146 (48%), Gaps = 175/1146 (15%)

Query: 765  ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
            + + + LNTL ++ EHY   +  + +  + N V   +FT EM +K+ ++    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 825  IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
             FD F+V   + E  L  +E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 880  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
            ++ +L L+L + + IF+++GMQLFG  +        ++ +  R    +F  + L VF++L
Sbjct: 649  SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702

Query: 940  CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
             GE W   M+D +        +G  +C+  F+++ + GN ++LN+FLA+ +     DNLA
Sbjct: 703  TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756

Query: 993  ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
               D   +N  Q             K +  E  +K   RK          E L NKK++ 
Sbjct: 757  ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789

Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
                                   + I +S  K  +D+        +P     VP  VGE 
Sbjct: 790  -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827

Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
                            EE +E+                       E EPE    P     
Sbjct: 828  ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848

Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
             +   K K   I     +G  ++ L KT      C+K++ H+ F   I+  I+LSS ALA
Sbjct: 849  SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904

Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
             ED  I       T+L Y D  FT IF +E+LLK   +G       +  N +  LD L+V
Sbjct: 905  AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963

Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
             VSLVS     +  S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++
Sbjct: 964  GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020

Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
            V  +   +F+ +GV LF GKFY C +            +N  EC+ L        ++S  
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071

Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
                 W+N   NFDNV    ++L  V+TF+GW  ++Y A+DS    + P Y   + + ++
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131

Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
            F+I+II  +FF +N+F+G +I  F +Q +K++   ++   + Q   Y A+K        +
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183

Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
            P+ R  P N +Q   +  V    F+  + +LI LN + + ++  +QS+   + +  +N+V
Sbjct: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243

Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
            F  +FT E VLK+I+ +   YF+  WN FD ++VI SI+ + L+E       +       
Sbjct: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFF 1303

Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV--K 1686
            RL R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++ FIYA+ GM  F  V  +
Sbjct: 1304 RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMR 1363

Query: 1687 REVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDH-PGSSVKGD 1745
                I+   NF+TF  +++ LF+  T   W  ++   L      CDP+ D+ PG      
Sbjct: 1364 DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG--KLCDPESDYNPGEEY--T 1419

Query: 1746 CGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKF 1805
            CG+ +  I +F+S+ ++   +++N+++AVI++NF   T + +  L     + F  +W ++
Sbjct: 1420 CGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEY 1477

Query: 1806 DPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFA 1860
            DP+A   I+   +      + PPL   K  P++V   +L+AM++P+ S   +     LFA
Sbjct: 1478 DPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFA 1537

Query: 1861 FTKRVL 1866
              +  L
Sbjct: 1538 LVRTAL 1543



 Score =  147 bits (372), Expect = 8e-35
 Identities = 107/376 (28%), Positives = 180/376 (47%), Gaps = 73/376 (19%)

Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
           AL+ L+  NPIR+  I I+    F++ I+  I  NCV + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
           EY F  I+T E+ +KI+A G  L    ++R+ WN LDF ++           +T+  + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
           +A+IGL+LF+G +   C                FF +S                      
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306

Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
                  +  + D   C  S +  QC   G  C      PN G T+FD F++A L++F+ 
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360

Query: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
           +T + W + LY +      +   ++FV ++  GSF+++NL+L V++  + +E+ +A    
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420

Query: 439 AEQKEAEFQQMLEQLK 454
             QK  E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436



 Score =  137 bits (346), Expect = 8e-32
 Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
            +R+ C  IVE   F+ FI+  I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
            F +E  LK +AYG       Y  N W  LDF+IV V L S+    L     G        
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
                +K+LR  R LRPLR +S    ++VV+N+++ A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
            LF GK +    +   ++         +   N  +C A   +   + W        NFDN 
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350

Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
                L++ Q  T +GW D++Y   D+   EL          ++YFV  +IFGSFF LNL 
Sbjct: 351  AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401

Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
            +GV+   F+++++K   +  F    +K+
Sbjct: 402  LGVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  126 bits (317), Expect = 2e-28
 Identities = 78/258 (30%), Positives = 133/258 (51%), Gaps = 31/258 (12%)

Query: 754  LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
            +V   PF +  + + I+LNTL +AM+HY  ++ F+  + + N+VFTG+FT EM LK+IA 
Sbjct: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259

Query: 814  DPYYYFQEGWNIFDGFIVSLSLMELGLANVE--------GLSVLRSFRLLRVFKLAKSWP 865
             P  YF + WN FD  IV  S++++ L+  +         ++  R FR++R+ KL     
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGE 1319

Query: 866  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHM 925
             +  L+     S  AL  + L++A++ FI+AV+GMQ+FGK     V    N+      + 
Sbjct: 1320 GIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK-----VAMRDNNQINRNNNF 1374

Query: 926  HDFFHSFLIVFRVLCGE-WIETMWDCME----------------VAGQTMCLTVFMMVMV 968
              F  + L++FR   GE W E M  C+                   G    +  F+   +
Sbjct: 1375 QTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYM 1434

Query: 969  IGNLVVLNLFLALLLSSF 986
            +   +++NLF+A+++ +F
Sbjct: 1435 LCAFLIINLFVAVIMDNF 1452



 Score =  102 bits (255), Expect = 3e-21
 Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)

Query: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
            L + + +  GE   E    E+  +  D ++ +EK       +G  +D    AE   PE E
Sbjct: 398  LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453

Query: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
             E            + E E+  TE+   + +        CQ   +    + W  WN   R
Sbjct: 454  EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513

Query: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
            + C   V+   F   ++ ++ L++  ++ E  +  Q   +  + + A+KV   +F  EML
Sbjct: 514  RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571

Query: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
            +K  + G Q YF + +   D  +V   +       L       I   R +R LR  +   
Sbjct: 572  VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631

Query: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
             +  +  +V +LL ++ SI ++LL+  +F +IFS++G+ LF GKF               
Sbjct: 632  HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676

Query: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
               N+ E        QT R       FDN     L++ Q+ T + W  +MY  +    + 
Sbjct: 677  ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717

Query: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
                    + + +YF+I  I G++  LN+F+ + +DN    +     Q     E+++K  
Sbjct: 718  YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777

Query: 1499 NAMKKLGSKKPQKP 1512
               + L +KK  KP
Sbjct: 778  ARKESLENKKNNKP 791



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)

Query: 28   RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
            +IA    K    + ++ED++  P P  D+  G+       D  PE+ + P     P  I+
Sbjct: 795  QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849

Query: 88   KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
            +     LN  + I+      A +IL+  NPIR    K++ H +F  LI+  I+ +   + 
Sbjct: 850  E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904

Query: 148  MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
              +P     +   +    +Y FT I+T E L+K+   G  L    F R+ +N LD  V+ 
Sbjct: 905  AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964

Query: 201  FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
             + V+  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ + ++MI+T  
Sbjct: 965  VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024

Query: 258  CLSVFALIGLQLFMG 272
               +FA IG+QLF G
Sbjct: 1025 LQFMFACIGVQLFKG 1039



 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)

Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
           +++V   PF D+ I + I  N + +A+ + P  E  S+     L      F  IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177

Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
           LKIIA    + P  Y + GWN+ D  IV + L  + L  +    EG            + 
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237

Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
            LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF GK 
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297

Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
           +K C               C  S           +C    W        +  +F  + L 
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356

Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
           VF+ +  E W + ++   +  G  +    F+ +++ G+  VLNL L +L   FS +
Sbjct: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)

Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
            +++ +++ Y   KK G+    +P          N  +      V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
             V + +     +D S    + L  +   F+++FT E  LK+I+         Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
             DFV+VI+ +  + L +L ++                + +R  R+ R LRL+ G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
            +L +++ ++  L +I LL+  V+ IYAI G+  F         +   ++  ++       
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
                                    + NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373

Query: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
                           D     +   +FVS +I     V+N+ + V+   FS   +E  + 
Sbjct: 374  --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416

Query: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
             +  DF+   E  ++ + D   ++++   ++  D
Sbjct: 417  KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 40/172 (23%), Positives = 82/172 (47%), Gaps = 19/172 (11%)

Query: 114  PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
            P NP +     ++  S F  ++   I+ N + + M +        D    +   FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249

Query: 168  FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDLGNVSALRT 218
             E ++K++A     +   +  D WN  D  ++  + +         +E  +  +++  R 
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRL 1305

Query: 219  FRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
            FRV+R +K +S   G++T++   I+S + L  V +L      ++A+IG+Q+F
Sbjct: 1306 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF 1357



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 16/154 (10%)

Query: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
           F  L++  +  N + ++    N PDW   ++         ++T E L+K+ + G      
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580

Query: 185 TFLRDPWNWLDFTVI------TFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 238
            +    +N  D  V+      T     E +    +S  R  R+LR  K       L  +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640

Query: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +L+ S+K ++ +++L    + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)

Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
           ++FD F  A L++F+++T + W  +    + A      +G    I+F+++   G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745

Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
           + LA+        E  N A  EEAE+KE +     E L+ ++         A+++++
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
            +FD    A ++LF + T + W  L    + + G+             IFF++ I + +F+
Sbjct: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142

Query: 416  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
            ++N+ +  V + ++EQ +   +  E  + + Q +   LK
Sbjct: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181


>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform b [Homo sapiens]
          Length = 2161

 Score =  420 bits (1080), Expect = e-117
 Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)

Query: 765  ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
            + + + LNTL ++ EHY   +  + +  + N V   +FT EM +K+ ++    YF   +N
Sbjct: 529  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588

Query: 825  IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
             FD F+V   + E  L  +E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 589  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648

Query: 880  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
            ++ +L L+L + + IF+++GMQLFG  +        ++ +  R    +F  + L VF++L
Sbjct: 649  SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702

Query: 940  CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
             GE W   M+D +        +G  +C+  F+++ + GN ++LN+FLA+ +     DNLA
Sbjct: 703  TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 756

Query: 993  ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
               D   +N  Q             K +  E  +K   RK          E L NKK++ 
Sbjct: 757  ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 789

Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
                                   + I +S  K  +D+        +P     VP  VGE 
Sbjct: 790  -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 827

Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
                            EE +E+                       E EPE    P     
Sbjct: 828  ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 848

Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
             +   K K   I     +G  ++ L KT      C+K++ H+ F   I+  I+LSS ALA
Sbjct: 849  SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904

Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
             ED  I       T+L Y D  FT IF +E+LLK   +G       +  N +  LD L+V
Sbjct: 905  AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 963

Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
             VSLVS     +  S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++
Sbjct: 964  GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1020

Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
            V  +   +F+ +GV LF GKFY C +            +N  EC+ L        ++S  
Sbjct: 1021 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1071

Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
                 W+N   NFDNV    ++L  V+TF+GW  ++Y A+DS    + P Y   + + ++
Sbjct: 1072 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1131

Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
            F+I+II  +FF +N+F+G +I  F +Q +K++   ++   + Q   Y A+K        +
Sbjct: 1132 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1183

Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
            P+ R  P N +Q   +  V    F+  + +LI LN + + ++  +QS+   + +  +N+V
Sbjct: 1184 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1243

Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
            F  +FT E VLK+I+ +   YF+  WN FD ++VI SI+ + L+E               
Sbjct: 1244 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1303

Query: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
                 E   +S T F   RL R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++
Sbjct: 1304 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1360

Query: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
             FIYA+ GM  F  V  +    I+   NF+TF  +++ LF+  T   W  ++   L    
Sbjct: 1361 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1418

Query: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
              CDP+ D+ PG      CG+ +  I +F+S+ ++   +++N+++AVI++NF   T + +
Sbjct: 1419 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1475

Query: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
              L     + F  +W ++DP+A   I+   +      + PPL   K  P++V   +L+AM
Sbjct: 1476 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1534

Query: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
            ++P+ S   +     LFA  +  L
Sbjct: 1535 NMPLNSDGTVMFNATLFALVRTAL 1558



 Score =  147 bits (372), Expect = 8e-35
 Identities = 107/376 (28%), Positives = 180/376 (47%), Gaps = 73/376 (19%)

Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
           AL+ L+  NPIR+  I I+    F++ I+  I  NCV + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
           EY F  I+T E+ +KI+A G  L    ++R+ WN LDF ++           +T+  + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
           +A+IGL+LF+G +   C                FF +S                      
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306

Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
                  +  + D   C  S +  QC   G  C      PN G T+FD F++A L++F+ 
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360

Query: 381 MTQDFWEN-LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
           +T + W + LY +      +   ++FV ++  GSF+++NL+L V++  + +E+ +A    
Sbjct: 361 ITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARG 420

Query: 439 AEQKEAEFQQMLEQLK 454
             QK  E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436



 Score =  137 bits (346), Expect = 8e-32
 Identities = 98/328 (29%), Positives = 157/328 (47%), Gaps = 41/328 (12%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
            +R+ C  IVE   F+ FI+  I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
            F +E  LK +AYG       Y  N W  LDF+IV V L S+    L     G        
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
                +K+LR  R LRPLR +S    ++VV+N+++ A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
            LF GK +    +   ++         +   N  +C A   +   + W        NFDN 
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350

Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
                L++ Q  T +GW D++Y   D+   EL          ++YFV  +IFGSFF LNL 
Sbjct: 351  AFAMLTVFQCITMEGWTDVLYWMNDAMGFELP---------WVYFVSLVIFGSFFVLNLV 401

Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
            +GV+   F+++++K   +  F    +K+
Sbjct: 402  LGVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  120 bits (302), Expect = 1e-26
 Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)

Query: 754  LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
            +V   PF +  + + I+LNTL +AM+HY  ++ F+  + + N+VFTG+FT EM LK+IA 
Sbjct: 1201 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1259

Query: 814  DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
             P  YF + WN FD  IV  S++++ L+  +                        ++  R
Sbjct: 1260 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1319

Query: 851  SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
             FR++R+ KL      +  L+     S  AL  + L++A++ FI+AV+GMQ+FGK     
Sbjct: 1320 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1374

Query: 911  VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
            V    N+      +   F  + L++FR   GE W E M  C+                  
Sbjct: 1375 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1434

Query: 954  AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
             G    +  F+   ++   +++NLF+A+++ +F
Sbjct: 1435 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1467



 Score =  102 bits (255), Expect = 3e-21
 Identities = 101/434 (23%), Positives = 180/434 (41%), Gaps = 62/434 (14%)

Query: 1101 LTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE 1160
            L + + +  GE   E    E+  +  D ++ +EK       +G  +D    AE   PE E
Sbjct: 398  LNLVLGVLSGEFSKER---EKAKARGDFQKLREKQQLEEDLKGY-LDWITQAEDIDPENE 453

Query: 1161 PE-----------ESLEPEACFTEDCVRKFK-------CCQISIEEGKGKLW--WNL--R 1198
             E            + E E+  TE+   + +        CQ   +    + W  WN   R
Sbjct: 454  EEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAISKSKLSRRWRRWNRFNR 513

Query: 1199 KTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEML 1258
            + C   V+   F   ++ ++ L++  ++ E  +  Q   +  + + A+KV   +F  EML
Sbjct: 514  RRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEML 571

Query: 1259 LKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALS 1318
            +K  + G Q YF + +   D  +V   +       L       I   R +R LR  +   
Sbjct: 572  VKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTR 631

Query: 1319 RFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVS 1378
             +  +  +V +LL ++ SI ++LL+  +F +IFS++G+ LF GKF               
Sbjct: 632  HWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------------- 676

Query: 1379 VVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVE 1438
               N+ E        QT R       FDN     L++ Q+ T + W  +MY  +    + 
Sbjct: 677  ---NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI----MA 717

Query: 1439 LQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYY 1498
                    + + +YF+I  I G++  LN+F+ + +DN    +     Q     E+++K  
Sbjct: 718  YGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKI 777

Query: 1499 NAMKKLGSKKPQKP 1512
               + L +KK  KP
Sbjct: 778  ARKESLENKKNNKP 791



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)

Query: 28   RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
            +IA    K    + ++ED++  P P  D+  G+       D  PE+ + P     P  I+
Sbjct: 795  QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 849

Query: 88   KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
            +     LN  + I+      A +IL+  NPIR    K++ H +F  LI+  I+ +   + 
Sbjct: 850  E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 904

Query: 148  MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
              +P     +   +    +Y FT I+T E L+K+   G  L    F R+ +N LD  V+ 
Sbjct: 905  AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 964

Query: 201  FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
             + V+  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ + ++MI+T  
Sbjct: 965  VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024

Query: 258  CLSVFALIGLQLFMG 272
               +FA IG+QLF G
Sbjct: 1025 LQFMFACIGVQLFKG 1039



 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)

Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
           +++V   PF D+ I + I  N + +A+ + P  E  S+     L      F  IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177

Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
           LKIIA    + P  Y + GWN+ D  IV + L  + L  +    EG            + 
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237

Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
            LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF GK 
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297

Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
           +K C               C  S           +C    W        +  +F  + L 
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356

Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
           VF+ +  E W + ++   +  G  +    F+ +++ G+  VLNL L +L   FS +
Sbjct: 357 VFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 80/394 (20%), Positives = 158/394 (40%), Gaps = 84/394 (21%)

Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
            +++ +++ Y   KK G+    +P          N  +      V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
             V + +     +D S    + L  +   F+++FT E  LK+I+         Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
             DFV+VI+ +  + L +L ++                + +R  R+ R LRL+ G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
            +L +++ ++  L +I LL+  V+ IYAI G+  F         +   ++  ++       
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
                                    + NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWM------ 373

Query: 1730 DCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEP 1789
                           D     +   +FVS +I     V+N+ + V+   FS   +E  + 
Sbjct: 374  --------------NDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS---KEREKA 416

Query: 1790 LSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
             +  DF+   E  ++ + D   ++++   ++  D
Sbjct: 417  KARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 43/187 (22%), Positives = 84/187 (44%), Gaps = 34/187 (18%)

Query: 114  PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
            P NP +     ++  S F  ++   I+ N + + M +        D    +   FTG++T
Sbjct: 1190 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1249

Query: 168  FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDL-------G 211
             E ++K++A     +   +  D WN  D  ++  + +         TE  ++       G
Sbjct: 1250 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1305

Query: 212  N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
            N        ++  R FRV+R +K +S   G++T++   I+S + L  V +L      ++A
Sbjct: 1306 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1365

Query: 264  LIGLQLF 270
            +IG+Q+F
Sbjct: 1366 VIGMQMF 1372



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 16/154 (10%)

Query: 131 FNMLIMCTILTNCVFMTMS--NPPDWTKNVE----YTFTGIYTFESLIKILARGFCLEDF 184
           F  L++  +  N + ++    N PDW   ++         ++T E L+K+ + G      
Sbjct: 525 FYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ---- 580

Query: 185 TFLRDPWNWLDFTVI------TFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIV 238
            +    +N  D  V+      T     E +    +S  R  R+LR  K       L  +V
Sbjct: 581 AYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLV 640

Query: 239 GALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +L+ S+K ++ +++L    + +F+L+G+QLF G
Sbjct: 641 ASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 674



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)

Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
           ++FD F  A L++F+++T + W  +    + A      +G    I+F+++   G++ L+N
Sbjct: 686 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 745

Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
           + LA+        E  N A  EEAE+KE +     E L+ ++         A+++++
Sbjct: 746 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
            +FD    A ++LF + T + W  L    + + G+             IFF++ I + +F+
Sbjct: 1083 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1142

Query: 416  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
            ++N+ +  V + ++EQ +   +  E  + + Q +   LK
Sbjct: 1143 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1181


>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
            subunit isoform a [Homo sapiens]
          Length = 2181

 Score =  420 bits (1080), Expect = e-117
 Identities = 336/1164 (28%), Positives = 559/1164 (48%), Gaps = 196/1164 (16%)

Query: 765  ITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWN 824
            + + + LNTL ++ EHY   +  + +  + N V   +FT EM +K+ ++    YF   +N
Sbjct: 549  VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 608

Query: 825  IFDGFIVSLSLMELGLANVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 879
             FD F+V   + E  L  +E     G+SV R  RLLR+FK+ + W +L+ L+  + NS+ 
Sbjct: 609  RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 668

Query: 880  ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVL 939
            ++ +L L+L + + IF+++GMQLFG  +        ++ +  R    +F  + L VF++L
Sbjct: 669  SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 722

Query: 940  CGE-WIETMWDCM------EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLA 992
             GE W   M+D +        +G  +C+  F+++ + GN ++LN+FLA+ +     DNLA
Sbjct: 723  TGEDWNAVMYDGIMAYGGPSSSGMIVCI-YFIILFICGNYILLNVFLAIAV-----DNLA 776

Query: 993  ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSC 1052
               D   +N  Q             K +  E  +K   RK          E L NKK++ 
Sbjct: 777  ---DAESLNTAQ-------------KEEAEEKERKKIARK----------ESLENKKNN- 809

Query: 1053 ISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGES 1112
                                   + I +S  K  +D+        +P     VP  VGE 
Sbjct: 810  -------------------KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVP--VGE- 847

Query: 1113 DFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFT 1172
                            EE +E+                       E EPE    P     
Sbjct: 848  ----------------EEEEEE-----------------------EDEPEVPAGPRPRRI 868

Query: 1173 EDCVRKFKCCQISIEEGKGKLWWNLRKT------CYKIVEHNWFETFIVFMILLSSGALA 1226
             +   K K   I     +G  ++ L KT      C+K++ H+ F   I+  I+LSS ALA
Sbjct: 869  SELNMKEKIAPIP----EGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924

Query: 1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYFTNAWCWLDFLIV 1282
             ED  I       T+L Y D  FT IF +E+LLK   +G       +  N +  LD L+V
Sbjct: 925  AED-PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVV 983

Query: 1283 DVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1342
             VSLVS     +  S +  +K LR LR LRPLRA++R +G++ VV  +  AI +I N+++
Sbjct: 984  GVSLVSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMI 1040

Query: 1343 VCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKAL--------IESNQ 1394
            V  +   +F+ +GV LF GKFY C +            +N  EC+ L        ++S  
Sbjct: 1041 VTTLLQFMFACIGVQLFKGKFYRCTD---------EAKSNPEECRGLFILYKDGDVDSPV 1091

Query: 1395 TAR--WKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLY 1452
                 W+N   NFDNV    ++L  V+TF+GW  ++Y A+DS    + P Y   + + ++
Sbjct: 1092 VRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIF 1151

Query: 1453 FVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1511
            F+I+II  +FF +N+F+G +I  F +Q +K++   ++   + Q   Y A+K        +
Sbjct: 1152 FIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------AR 1203

Query: 1512 PIPR--PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLV 1569
            P+ R  P N +Q   +  V    F+  + +LI LN + + ++  +QS+   + +  +N+V
Sbjct: 1204 PLRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMV 1263

Query: 1570 FIVLFTGECVLKLISLR-YYYFTIGWNIFDFVVVILSIVGMFLAEL-------------- 1614
            F  +FT E VLK+I+ +   YF+  WN FD ++VI SI+ + L+E               
Sbjct: 1264 FTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTAT 1323

Query: 1615 ----IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
                 E   +S T F   RL R+ R+++L+   +GIRTLL+  + S  AL  + LL+ ++
Sbjct: 1324 PGNSEESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1380

Query: 1671 MFIYAIFGMSNFAYV--KREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
             FIYA+ GM  F  V  +    I+   NF+TF  +++ LF+  T   W  ++   L    
Sbjct: 1381 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPG-- 1438

Query: 1729 PDCDPDKDH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1787
              CDP+ D+ PG      CG+ +  I +F+S+ ++   +++N+++AVI++NF   T + +
Sbjct: 1439 KLCDPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1495

Query: 1788 EPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAM 1842
              L     + F  +W ++DP+A   I+   +      + PPL   K  P++V   +L+AM
Sbjct: 1496 -ILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAM 1554

Query: 1843 DLPMVSGDRIHCLDILFAFTKRVL 1866
            ++P+ S   +     LFA  +  L
Sbjct: 1555 NMPLNSDGTVMFNATLFALVRTAL 1578



 Score =  149 bits (377), Expect = 2e-35
 Identities = 109/376 (28%), Positives = 181/376 (48%), Gaps = 73/376 (19%)

Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-PDWTKN--------V 158
           AL+ L+  NPIR+  I I+    F++ I+  I  NCV + +  P P+   N        V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164

Query: 159 EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAY-------VTEFVDLG 211
           EY F  I+T E+ +KI+A G  L    ++R+ WN LDF ++           +T+  + G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224

Query: 212 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 261
           N          V ALR FRVLR L+ +S +P L+ ++ ++I+++  L  + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

Query: 262 FALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIE 321
           +A+IGL+LF+G +   C                FF +S                      
Sbjct: 285 YAIIGLELFIGKMHKTC----------------FFADS---------------------- 306

Query: 322 DKSHFYFLEGQNDALLCGNSSDAGQC-PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRL 380
                  +  + D   C  S +  QC   G  C      PN G T+FD F++A L++F+ 
Sbjct: 307 ------DIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQC 360

Query: 381 MTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINLILAVVAMAY-EEQNQATLEE 438
           +T + W ++      A G  +  ++FV +I LGSF+++NL+L V++  + +E+ +A    
Sbjct: 361 ITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAKARG 420

Query: 439 AEQKEAEFQQMLEQLK 454
             QK  E QQ+ E LK
Sbjct: 421 DFQKLREKQQLEEDLK 436



 Score =  133 bits (335), Expect = 2e-30
 Identities = 97/328 (29%), Positives = 156/328 (47%), Gaps = 41/328 (12%)

Query: 1197 LRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYI----EQRKTIKTMLEYADKVFTYI 1252
            +R+ C  IVE   F+ FI+  I  +  ALA   IYI    +   +    LE  +  F  I
Sbjct: 115  IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171

Query: 1253 FILEMLLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA------- 1301
            F +E  LK +AYG       Y  N W  LDF+IV V L S+    L     G        
Sbjct: 172  FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231

Query: 1302 ----IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1357
                +K+LR  R LRPLR +S    ++VV+N+++ A+  ++++ L+ L   +I++I+G+ 
Sbjct: 232  GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291

Query: 1358 LFAGKFYHCINYTTGEMF------DVSVVNNYSECKALIESNQTARWKNVK---VNFDNV 1408
            LF GK +    +   ++         +   N  +C A   +   + W        NFDN 
Sbjct: 292  LFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCTA-NGTECRSGWVGPNGGITNFDNF 350

Query: 1409 GLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1468
                L++ Q  T +GW D++Y   D+   E         + ++YFV  II GSFF LNL 
Sbjct: 351  AFAMLTVFQCITMEGWTDVLYWVNDAIGWE---------WPWVYFVSLIILGSFFVLNLV 401

Query: 1469 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1496
            +GV+   F+++++K   +  F    +K+
Sbjct: 402  LGVLSGEFSKEREKAKARGDFQKLREKQ 429



 Score =  120 bits (302), Expect = 1e-26
 Identities = 78/273 (28%), Positives = 133/273 (48%), Gaps = 46/273 (16%)

Query: 754  LVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAM 813
            +V   PF +  + + I+LNTL +AM+HY  ++ F+  + + N+VFTG+FT EM LK+IA 
Sbjct: 1221 VVNSSPF-EYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAF 1279

Query: 814  DPYYYFQEGWNIFDGFIVSLSLMELGLANVE-----------------------GLSVLR 850
             P  YF + WN FD  IV  S++++ L+  +                        ++  R
Sbjct: 1280 KPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFR 1339

Query: 851  SFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC 910
             FR++R+ KL      +  L+     S  AL  + L++A++ FI+AV+GMQ+FGK     
Sbjct: 1340 LFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK----- 1394

Query: 911  VCKISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME----------------V 953
            V    N+      +   F  + L++FR   GE W E M  C+                  
Sbjct: 1395 VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYT 1454

Query: 954  AGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
             G    +  F+   ++   +++NLF+A+++ +F
Sbjct: 1455 CGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1487



 Score =  100 bits (249), Expect = 1e-20
 Identities = 78/320 (24%), Positives = 140/320 (43%), Gaps = 38/320 (11%)

Query: 1195 WNL--RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYI 1252
            WN   R+ C   V+   F   ++ ++ L++  ++ E  +  Q   +  + + A+KV   +
Sbjct: 528  WNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLAL 585

Query: 1253 FILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALR 1312
            F  EML+K  + G Q YF + +   D  +V   +       L       I   R +R LR
Sbjct: 586  FTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLR 645

Query: 1313 PLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTG 1372
              +    +  +  +V +LL ++ SI ++LL+  +F +IFS++G+ LF GKF         
Sbjct: 646  IFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF--------- 696

Query: 1373 EMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAV 1432
                     N+ E        QT R       FDN     L++ Q+ T + W  +MY  +
Sbjct: 697  ---------NFDE-------TQTKR-----STFDNFPQALLTVFQILTGEDWNAVMYDGI 735

Query: 1433 DSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1492
                +         + + +YF+I  I G++  LN+F+ + +DN    +     Q     E
Sbjct: 736  ----MAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEE 791

Query: 1493 EQKKYYNAMKKLGSKKPQKP 1512
            +++K     + L +KK  KP
Sbjct: 792  KERKKIARKESLENKKNNKP 811



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 73/255 (28%), Positives = 123/255 (48%), Gaps = 20/255 (7%)

Query: 28   RIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYIN 87
            +IA    K    + ++ED++  P P  D+  G+       D  PE+ + P     P  I+
Sbjct: 815  QIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEEEEEEEED-EPEVPAGPR----PRRIS 869

Query: 88   KKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMT 147
            +     LN  + I+      A +IL+  NPIR    K++ H +F  LI+  I+ +   + 
Sbjct: 870  E-----LNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924

Query: 148  MSNP---PDWTKNV----EYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVIT 200
              +P     +   +    +Y FT I+T E L+K+   G  L    F R+ +N LD  V+ 
Sbjct: 925  AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVG 984

Query: 201  FAYVTEFVDLGNVSA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 257
             + V+  +    +S    LR  RVLR L+ I+   GLK +V  +  +++ + ++MI+T  
Sbjct: 985  VSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1044

Query: 258  CLSVFALIGLQLFMG 272
               +FA IG+QLF G
Sbjct: 1045 LQFMFACIGVQLFKG 1059



 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 77/296 (26%), Positives = 133/296 (44%), Gaps = 61/296 (20%)

Query: 752 VNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSV----LSVGNLVFTGIFTAEMF 807
           +++V   PF D+ I + I  N + +A+ + P  E  S+     L      F  IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177

Query: 808 LKIIA----MDPYYYFQEGWNIFDGFIVSLSLMELGLANV----EG------------LS 847
           LKIIA    + P  Y + GWN+ D  IV + L  + L  +    EG            + 
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237

Query: 848 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 906
            LR+FR+LR  +L    P+L +++  I  ++  L ++ L++  ++ I+A++G++LF GK 
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297

Query: 907 YKECV--------------CKIS----------NDCELPRW--------HMHDFFHSFLI 934
           +K C               C  S           +C    W        +  +F  + L 
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECR-SGWVGPNGGITNFDNFAFAMLT 356

Query: 935 VFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD 989
           VF+ +  E W + ++   +  G       F+ ++++G+  VLNL L +L   FS +
Sbjct: 357 VFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 82/398 (20%), Positives = 161/398 (40%), Gaps = 92/398 (23%)

Query: 1490 MTEEQKKYYNAMKKLGSKKPQKPIPRPA-----NKFQGMVFDFVTKQVFDISIMILICLN 1544
            +++ +++ Y   KK G+    +P          N  +      V  + FDI I++ I  N
Sbjct: 80   LSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFAN 139

Query: 1545 MVTMMVET---DDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY-----YFTIGWNI 1596
             V + +     +D S    + L  +   F+++FT E  LK+I+         Y   GWN+
Sbjct: 140  CVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNL 199

Query: 1597 FDFVVVILSIVGMFLAELIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIRT 1648
             DFV+VI+ +  + L +L ++                + +R  R+ R LRL+ G   ++ 
Sbjct: 200  LDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQV 259

Query: 1649 LLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA--------YVKREVGIDD------- 1693
            +L +++ ++  L +I LL+  V+ IYAI G+  F         +   ++  ++       
Sbjct: 260  VLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAF 319

Query: 1694 ------------------------MFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPP 1729
                                    + NF+ F  +M+ +FQ  T  GW  +L  +      
Sbjct: 320  SGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV------ 373

Query: 1730 DCDPDKDHPGSSVKGDCGNPSVG----IFFFVSYIIISFLVVVNMYIAVILENFSVATEE 1785
                              N ++G      +FVS II+    V+N+ + V+   FS   +E
Sbjct: 374  ------------------NDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFS---KE 412

Query: 1786 SAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFAD 1823
              +  +  DF+   E  ++ + D   ++++   ++  D
Sbjct: 413  REKAKARGDFQKLREK-QQLEEDLKGYLDWITQAEDID 449



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 43/187 (22%), Positives = 84/187 (44%), Gaps = 34/187 (18%)

Query: 114  PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYT 167
            P NP +     ++  S F  ++   I+ N + + M +        D    +   FTG++T
Sbjct: 1210 PKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFT 1269

Query: 168  FESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV---------TEFVDL-------G 211
             E ++K++A     +   +  D WN  D  ++  + +         TE  ++       G
Sbjct: 1270 VEMVLKVIA----FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPG 1325

Query: 212  N--------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
            N        ++  R FRV+R +K +S   G++T++   I+S + L  V +L      ++A
Sbjct: 1326 NSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYA 1385

Query: 264  LIGLQLF 270
            +IG+Q+F
Sbjct: 1386 VIGMQMF 1392



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 45/189 (23%), Positives = 84/189 (44%), Gaps = 20/189 (10%)

Query: 97  GKAISRFSATPALYILTPFNPIR-KLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPPD 153
           G+AIS+   +        FN  R + A+K +    F  L++  +  N + ++    N PD
Sbjct: 513 GQAISKSKLSRRWRRWNRFNRRRCRAAVKSVT---FYWLVIVLVFLNTLTISSEHYNQPD 569

Query: 154 WTKNVE----YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVI------TFAY 203
           W   ++         ++T E L+K+ + G       +    +N  D  V+      T   
Sbjct: 570 WLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFVSLFNRFDCFVVCGGITETILV 625

Query: 204 VTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 263
             E +    +S  R  R+LR  K       L  +V +L+ S+K ++ +++L    + +F+
Sbjct: 626 ELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFS 685

Query: 264 LIGLQLFMG 272
           L+G+QLF G
Sbjct: 686 LLGMQLFGG 694



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 9/117 (7%)

Query: 365 TSFDTFSWAFLSLFRLMTQDFWENLYQLTLRA------AGKTYMIFFVLVIFLGSFYLIN 418
           ++FD F  A L++F+++T + W  +    + A      +G    I+F+++   G++ L+N
Sbjct: 706 STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLN 765

Query: 419 LILAVVA---MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
           + LA+        E  N A  EEAE+KE +     E L+ ++         A+++++
Sbjct: 766 VFLAIAVDNLADAESLNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 822



 Score = 37.0 bits (84), Expect = 0.19
 Identities = 22/99 (22%), Positives = 47/99 (47%), Gaps = 10/99 (10%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY----------MIFFVLVIFLGSFY 415
            +FD    A ++LF + T + W  L    + + G+             IFF++ I + +F+
Sbjct: 1103 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFF 1162

Query: 416  LINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLK 454
            ++N+ +  V + ++EQ +   +  E  + + Q +   LK
Sbjct: 1163 MMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALK 1201


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  338 bits (866), Expect = 4e-92
 Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1125 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1184

Query: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1185 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1244

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1245 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1302

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
                 D   + N S+C A        RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1303 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1353

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1354 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1413

Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1414 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1471

Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
            E  +Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1472 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1531

Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1532 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1591

Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1592 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1651

Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
             L     DC  D+    SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1652 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701

Query: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
             +E+ E  +E D E+  E+     P
Sbjct: 1702 NKEAQED-AEMDAELELEMAHGLGP 1725



 Score =  143 bits (360), Expect = 2e-33
 Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)

Query: 738  IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 584  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 643

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 644  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 703

Query: 858  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG       CK S  
Sbjct: 704  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 756

Query: 916  ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
                D    R +      + + VF++L  E W   +++ M        L  F+ +M  GN
Sbjct: 757  TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 815

Query: 972  LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
             V+ NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 816  YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 861



 Score =  130 bits (328), Expect = 1e-29
 Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)

Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
           A + L      R   IK++ +  F  + M  IL NCV + M  P        D  K ++ 
Sbjct: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117

Query: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
               I+ F   E ++K++A G   +   +L D WN LDF ++    V   +DL N+  SA
Sbjct: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176

Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
           +RT RVLR LK I+ +P ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236

Query: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
           N+C           +  PP     E +   F  +    NG      +        E    
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296

Query: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
           K   Y F  G+ D    G   +  +     +C     NP+ G  +FD   +A++ +F+++
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354

Query: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
           T + W  +    + A      I+F+L+I +GSF++INL L V+A  +          +E 
Sbjct: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404

Query: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
           K+ E + MLEQ   +Q    ++  A+ AE  D
Sbjct: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433



 Score =  112 bits (280), Expect = 4e-24
 Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)

Query: 715  MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
            +  LE+ R+K     Y +A  C            + L++ +    ++D+ IT  I LN +
Sbjct: 1419 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1467

Query: 775  FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
             M++EHY       + L   N +FT +F  E  LK++A     +F++ WN  D  IV LS
Sbjct: 1468 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1527

Query: 835  LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
            +M + L  +E           + ++R  R+ RV KL K    +  L+  +  ++  +GNL
Sbjct: 1528 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1587

Query: 885  TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
             L+  ++ FI+A +G++LFGK     VC   N CE    H    +F  +FL +F+V  G+
Sbjct: 1588 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1643

Query: 943  -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
             W     +T+ DC     +  CL+         F+  ++    V++N+ +A+L+      
Sbjct: 1644 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1701

Query: 990  NLAATDD 996
            N  A +D
Sbjct: 1702 NKEAQED 1708



 Score =  102 bits (255), Expect = 3e-21
 Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
            P N+F+ +    +  ++FD  ++  I LN +T+ +E        T  ++    N +F  +
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1179

Query: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1180 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1239

Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1240 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1299

Query: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
             +G+D                     +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1300 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1359

Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
             D  P  +H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1360 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)

Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
            S++S  E S    +A    E       +  +G   E+  EE  E +A   +  V  + C 
Sbjct: 534  STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 587

Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
                    G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +L
Sbjct: 588  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 637

Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
            E  + VFT +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +
Sbjct: 638  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 692

Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 693  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 752

Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
            F   +   TG+                            + NFD++    +++ Q+ T +
Sbjct: 753  F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 786

Query: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
             W  ++Y  + S +           +  LYFV  + FG++   NL + ++++ F  +   
Sbjct: 787  DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 836

Query: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
             + +  +D   +  EE  K    +   G  K   PIP   N
Sbjct: 837  NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 876



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)

Query: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
            P  + + L   ++     D  +   I LN + +A+E  P  E  S+    L+V N +FT 
Sbjct: 1120 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1178

Query: 801  IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
            IF  EM LK++++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L V
Sbjct: 1179 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1238

Query: 849  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
            LR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   + 
Sbjct: 1239 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1298

Query: 909  ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
             C+      I+N  DC     RW  H    D     L+   VL  +  W+  M++ ++  
Sbjct: 1299 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1358

Query: 955  G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
                          L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1359 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1399



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
            S   S   +  P +G  P V P   L P A F   C+R+                 + R 
Sbjct: 30   SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70

Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
             C K+V + WFE   + +ILL+   L       +        K +  + D +F + F +E
Sbjct: 71   WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129

Query: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
            M+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++RT+R LRP
Sbjct: 130  MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            L+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
            V  + F+  IM+ I +N V+M +E  +Q +E+TNIL   N+VF  +F  E +LKL +   
Sbjct: 602  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 661

Query: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 662  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 713

Query: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 714  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 773

Query: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 774  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 812

Query: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
                V+ N+ +A+++E F    + +     ED               ++   EF KL + 
Sbjct: 813  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 859

Query: 1822 ADALDPPLLIAKP 1834
             D+   P L   P
Sbjct: 860  LDSSGDPKLCPIP 872



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)

Query: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
            ++Y+ +P N  R L   I+ H LF+ +++  I  NC+ + +  P     + E        
Sbjct: 1114 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1173

Query: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 1174 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1233

Query: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1234 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1293

Query: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
             G   + CL     N            N  D     +      +N+D   +     + L 
Sbjct: 1294 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1342

Query: 331  GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
             +                +G++        N  Y   D  +   +    +   + W  LY
Sbjct: 1343 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1375

Query: 391  QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
                        I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++ L
Sbjct: 1376 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1419

Query: 451  EQLKKQQEEAQ 461
             +L+K++ +AQ
Sbjct: 1420 RRLEKKRRKAQ 1430



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)

Query: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
           FN  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 607 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 662

Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 663 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 721

Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
           +++  ++   +L +  + +F+++G+ +F    +LR       PD  +F+
Sbjct: 722 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 770



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
           +V +P+ +    + I+LN + + M    +          +L V +      F  EM LK+
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134

Query: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
           +A+  +    Y  + WN  D FIV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193

Query: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253

Query: 921 PRWH 924
           P ++
Sbjct: 254 PPYY 257



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT  M    DD     +   IL   +    + F  E VLK+++L  +
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)

Query: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1623 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1682

Query: 413  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
             F LIN+++AV+    ++ N+   E+AE  +AE +  LE         +    +  A  R
Sbjct: 1683 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1739

Query: 473  DFSGAGGIG 481
               GAGG G
Sbjct: 1740 GPGGAGGGG 1748



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 828 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 858



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  338 bits (866), Expect = 4e-92
 Identities = 208/625 (33%), Positives = 342/625 (54%), Gaps = 39/625 (6%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C  I+ H  F+  ++  I L+   +A E   IE   T +  L  ++ +FT IF+ EM
Sbjct: 1160 RVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEM 1219

Query: 1258 LLKWVA----YGFQVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
             LK V+    +G Q Y  ++W  LD  +V VS++ +    A+A G   LG ++ LR LR 
Sbjct: 1220 TLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRT 1279

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFYHC+   
Sbjct: 1280 LRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-- 1337

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
                 D   + N S+C A        RW + K NFDN+G   +SL  +A+  GW++IMY 
Sbjct: 1338 ----VDTRNITNRSDCMA-----ANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYN 1388

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1389 GLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1448

Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
             EE  K    ++K   K  + P        + ++    T    DI I  +ICLN+VTM +
Sbjct: 1449 REE--KRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSL 1506

Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
            E  +Q   +   L + N +F  +F  E VLKL++     +F   WN  D  +V+LS++G+
Sbjct: 1507 EHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGI 1566

Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1567 TLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1626

Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
             L+ FIYA  G+  F  +         G+     FE FG + + LFQ++T   W+G++  
Sbjct: 1627 MLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKD 1686

Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
             L     DC  D+    SS++       V   +FVS+++ +  V++N+ +AV++++   +
Sbjct: 1687 TLR----DCTHDERSCLSSLQ------FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736

Query: 1783 TEESAEPLSEDDFEMFYEVWEKFDP 1807
             +E+ E  +E D E+  E+     P
Sbjct: 1737 NKEAQED-AEMDAELELEMAHGLGP 1760



 Score =  143 bits (360), Expect = 2e-33
 Identities = 85/287 (29%), Positives = 154/287 (53%), Gaps = 18/287 (6%)

Query: 738  IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            +W C   W + +  +  +V   + +  I + I++NT+ M +EH+   E+ +++L + N+V
Sbjct: 619  VWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVV 678

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 857
            FT +F  EM LK+ A   + Y +  +NIFD  IV +S+ E+      GLSVLR+FRLLRV
Sbjct: 679  FTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRV 738

Query: 858  FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-- 915
             KL +  P L   + ++  ++  +    ++L + +FIF+++GM +FG       CK S  
Sbjct: 739  LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLR 791

Query: 916  ---NDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
                D    R +      + + VF++L  E W   +++ M        L  F+ +M  GN
Sbjct: 792  TDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASL-YFVALMTFGN 850

Query: 972  LVVLNLFLALLLSSFSSD---NLAATDDDNEMNNLQIAVGRMQKGID 1015
             V+ NL +A+L+  F ++   N + +D+D   +N++    ++Q+G+D
Sbjct: 851  YVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIE-EFDKLQEGLD 896



 Score =  130 bits (328), Expect = 1e-29
 Identities = 110/392 (28%), Positives = 181/392 (46%), Gaps = 42/392 (10%)

Query: 108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP-------PDWTKNVEY 160
           A + L      R   IK++ +  F  + M  IL NCV + M  P        D  K ++ 
Sbjct: 58  AFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQV 117

Query: 161 TFTGIYTF---ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNV--SA 215
               I+ F   E ++K++A G   +   +L D WN LDF ++    V   +DL N+  SA
Sbjct: 118 FDDFIFIFFAMEMVLKMVALGIFGKK-CYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSA 176

Query: 216 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 275
           +RT RVLR LK I+ +P ++ +V  L+ ++  L +V++L  F   +F +IG+QL+ G LR
Sbjct: 177 IRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236

Query: 276 NKC-----------LQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWD--EYIED 322
           N+C           +  PP     E +   F  +    NG      +        E    
Sbjct: 237 NRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLS 296

Query: 323 KSHFY-FLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLM 381
           K   Y F  G+ D    G   +  +     +C     NP+ G  +FD   +A++ +F+++
Sbjct: 297 KDDVYDFGAGRQDLNASGLCVNWNRYYN--VCRTGSANPHKGAINFDNIGYAWIVIFQVI 354

Query: 382 TQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ 441
           T + W  +    + A      I+F+L+I +GSF++INL L V+A  +          +E 
Sbjct: 355 TLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF----------SET 404

Query: 442 KEAEFQQMLEQLKKQQEEAQAAAAAASAESRD 473
           K+ E + MLEQ   +Q    ++  A+ AE  D
Sbjct: 405 KQREHRLMLEQ---RQRYLSSSTVASYAEPGD 433



 Score =  112 bits (280), Expect = 4e-24
 Identities = 84/307 (27%), Positives = 145/307 (47%), Gaps = 42/307 (13%)

Query: 715  MEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTL 774
            +  LE+ R+K     Y +A  C            + L++ +    ++D+ IT  I LN +
Sbjct: 1454 LRRLEKKRRKAQRLPY-YATYC----------HTRLLIHSMCTSHYLDIFITFIICLNVV 1502

Query: 775  FMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLS 834
             M++EHY       + L   N +FT +F  E  LK++A     +F++ WN  D  IV LS
Sbjct: 1503 TMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLS 1562

Query: 835  LMELGLANVE----------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 884
            +M + L  +E           + ++R  R+ RV KL K    +  L+  +  ++  +GNL
Sbjct: 1563 VMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNL 1622

Query: 885  TLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE 942
             L+  ++ FI+A +G++LFGK     VC   N CE    H    +F  +FL +F+V  G+
Sbjct: 1623 GLLFMLLFFIYAALGVELFGK----LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGD 1678

Query: 943  -W----IETMWDCMEVAGQTMCLT--------VFMMVMVIGNLVVLNLFLALLLSSFSSD 989
             W     +T+ DC     +  CL+         F+  ++    V++N+ +A+L+      
Sbjct: 1679 NWNGIMKDTLRDCTH--DERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDS 1736

Query: 990  NLAATDD 996
            N  A +D
Sbjct: 1737 NKEAQED 1743



 Score =  102 bits (255), Expect = 3e-21
 Identities = 74/291 (25%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWI--NLVFIVL 1573
            P N+F+ +    +  ++FD  ++  I LN +T+ +E        T  ++    N +F  +
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAI 1214

Query: 1574 FTGECVLKLISLRYY-----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
            F GE  LK++SL  Y     Y    WN+ D  +V +SI+ + ++           + RV+
Sbjct: 1215 FVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVL 1274

Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNF-AYVKR 1687
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+  F      
Sbjct: 1275 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1334

Query: 1688 EVGID-------------------DMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
             +G+D                     +NF+  G +++ LF + +  GW  ++   L++  
Sbjct: 1335 CLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVA 1394

Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
             D  P  +H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1395 VDQQPVTNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 94/401 (23%), Positives = 171/401 (42%), Gaps = 63/401 (15%)

Query: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
            S++S  E S    +A    E       +  +G   E+  EE  E +A   +  V  + C 
Sbjct: 569  STDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQA---DGAV--WLC- 622

Query: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
                    G +W   R     IV+  +F   I+  IL+++ ++  E  + EQ + +  +L
Sbjct: 623  --------GDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIE--HHEQPEELTNIL 672

Query: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
            E  + VFT +F LEM+LK  A+G   Y  N +   D +IV +S+  +   A      G +
Sbjct: 673  EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA-----DGGL 727

Query: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
              LRT R LR L+ +     +R  +  L+  + ++    ++ ++F  IFSI+G+++F  K
Sbjct: 728  SVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCK 787

Query: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
            F   +   TG+                            + NFD++    +++ Q+ T +
Sbjct: 788  F--SLRTDTGDTVP------------------------DRKNFDSLLWAIVTVFQILTQE 821

Query: 1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ--- 1479
             W  ++Y  + S +           +  LYFV  + FG++   NL + ++++ F  +   
Sbjct: 822  DWNVVLYNGMASTSP----------WASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDA 871

Query: 1480 KKKFGGQDIFMT--EEQKKYYNAMKKLGSKKPQKPIPRPAN 1518
             + +  +D   +  EE  K    +   G  K   PIP   N
Sbjct: 872  NRSYSDEDQSSSNIEEFDKLQEGLDSSGDPK-LCPIPMTPN 911



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 75/281 (26%), Positives = 135/281 (48%), Gaps = 39/281 (13%)

Query: 744  PWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTG 800
            P  + + L   ++     D  +   I LN + +A+E  P  E  S+    L+V N +FT 
Sbjct: 1155 PENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALER-PQIEAGSTERIFLTVSNYIFTA 1213

Query: 801  IFTAEMFLKIIAMDPYY----YFQEGWNIFDGFIVSLSLMEL--GLANVEG------LSV 848
            IF  EM LK++++  Y+    Y +  WN+ DGF+V +S++++   LA+  G      L V
Sbjct: 1214 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRV 1273

Query: 849  LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYK 908
            LR  R LR  ++    P L ++++ + +S+  +GN+ L+      IF ++G+QLF   + 
Sbjct: 1274 LRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFY 1333

Query: 909  ECV----CKISN--DCELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVA 954
             C+      I+N  DC     RW  H    D     L+   VL  +  W+  M++ ++  
Sbjct: 1334 HCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAV 1393

Query: 955  G---------QTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
                          L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1394 AVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF 1434



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 30/228 (13%)

Query: 1140 SSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRK 1199
            S   S   +  P +G  P V P   L P A F   C+R+                 + R 
Sbjct: 30   SPPSSPPGLEEPLDGADPHV-PHPDLAPIAFF---CLRQTT---------------SPRN 70

Query: 1200 TCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQ---RKTIKTMLEYADKVFTYIFILE 1256
             C K+V + WFE   + +ILL+   L       +        K +  + D +F + F +E
Sbjct: 71   WCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIF-FAME 129

Query: 1257 MLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
            M+LK VA   +G + Y  + W  LDF IV   +V  + +    +    + ++RT+R LRP
Sbjct: 130  MVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN----LSAIRTVRVLRP 185

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            L+A++R   MR++VN LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 186  LKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 81/313 (25%), Positives = 145/313 (46%), Gaps = 48/313 (15%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY 1587
            V  + F+  IM+ I +N V+M +E  +Q +E+TNIL   N+VF  +F  E +LKL +   
Sbjct: 637  VDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL 696

Query: 1588 Y-YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1646
            + Y    +NIFD ++VI+SI      E++ +   +     V+R  R+ R+L+L++    +
Sbjct: 697  FDYLRNPYNIFDSIIVIISI-----WEIVGQ---ADGGLSVLRTFRLLRVLKLVRFMPAL 748

Query: 1647 RTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG--IDDMFNFETFG 1701
            R  L  LM ++  +    +LL L +FI++I GM  F     ++ + G  + D  NF++  
Sbjct: 749  RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLL 808

Query: 1702 NSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYII 1761
             +++ +FQI T   W+ +L   + S  P                         +FV+ + 
Sbjct: 809  WAIVTVFQILTQEDWNVVLYNGMASTSPWAS---------------------LYFVALMT 847

Query: 1762 ISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDF 1821
                V+ N+ +A+++E F    + +     ED               ++   EF KL + 
Sbjct: 848  FGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQ-------------SSSNIEEFDKLQEG 894

Query: 1822 ADALDPPLLIAKP 1834
             D+   P L   P
Sbjct: 895  LDSSGDPKLCPIP 907



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 85/371 (22%), Positives = 156/371 (42%), Gaps = 71/371 (19%)

Query: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE-------- 159
            ++Y+ +P N  R L   I+ H LF+ +++  I  NC+ + +  P     + E        
Sbjct: 1149 SVYLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSN 1208

Query: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--------- 210
            Y FT I+  E  +K+++ G    +  +LR  WN LD  ++  + +   V L         
Sbjct: 1209 YIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKIL 1268

Query: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
            G +  LR  R LR L+ IS  PGLK +V  LI S+K + +++++      +F ++G+QLF
Sbjct: 1269 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLF 1328

Query: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
             G   + CL     N            N  D     +      +N+D   +     + L 
Sbjct: 1329 KGKFYH-CLGVDTRN----------ITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLA 1377

Query: 331  GQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
             +                +G++        N  Y   D  +   +    +   + W  LY
Sbjct: 1378 SK----------------DGWV--------NIMYNGLDAVA---VDQQPVTNHNPWMLLY 1410

Query: 391  QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQML 450
                        I F+L++   SF+++N+ + VV   + +  Q   +EAE+     ++ L
Sbjct: 1411 -----------FISFLLIV---SFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRL 1454

Query: 451  EQLKKQQEEAQ 461
             +L+K++ +AQ
Sbjct: 1455 RRLEKKRRKAQ 1465



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 50/169 (29%), Positives = 89/169 (52%), Gaps = 15/169 (8%)

Query: 131 FNMLIMCTILTNCVFMTMSN---PPDWTKNVEY---TFTGIYTFESLIKILARGFCLEDF 184
           FN  IM  IL N V M + +   P + T  +E     FT ++  E ++K+ A G     F
Sbjct: 642 FNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGL----F 697

Query: 185 TFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLKTIVGALI 242
            +LR+P+N  D ++I    + E V    G +S LRTFR+LR LK +  +P L+  +  L+
Sbjct: 698 DYLRNPYNIFD-SIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLM 756

Query: 243 QSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFE 289
           +++  ++   +L +  + +F+++G+ +F    +LR       PD  +F+
Sbjct: 757 KTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFD 805



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 32/98 (32%), Positives = 60/98 (61%), Gaps = 13/98 (13%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++ + QV T +GW++IMY  +D+           + Y ++YF++ II GSF
Sbjct: 338  INFDNIGYAWIVIFQVITLEGWVEIMYYVMDAH----------SFYNFIYFILLIIVGSF 387

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNA 1500
            F +NL + VI   F++ K++   +   M E++++Y ++
Sbjct: 388  FMINLCLVVIATQFSETKQR---EHRLMLEQRQRYLSS 422



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 49/184 (26%), Positives = 91/184 (49%), Gaps = 15/184 (8%)

Query: 755 VVMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI 810
           +V +P+ +    + I+LN + + M    +          +L V +      F  EM LK+
Sbjct: 75  MVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKM 134

Query: 811 IAMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWP 865
           +A+  +    Y  + WN  D FIV   ++E  L L N+  LS +R+ R+LR  K     P
Sbjct: 135 VALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-LSAIRTVRVLRPLKAINRVP 193

Query: 866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-----GKSYKECVCKISNDCEL 920
           ++ +L+ ++ +++  LGN+ L+   + FIF ++G+QL+      + + E    I  D  L
Sbjct: 194 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVAL 253

Query: 921 PRWH 924
           P ++
Sbjct: 254 PPYY 257



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 49/163 (30%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVT--MMVETDDQS--QEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT  M    DD     +   IL   +    + F  E VLK+++L  +
Sbjct: 81   FECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIF 140

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +V+  +V   L        +       IR  R+ R L+ I    
Sbjct: 141  GKKCYLGDTWNRLDFFIVMAGMVEYSLD-------LQNINLSAIRTVRVLRPLKAINRVP 193

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 194  SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLR 236



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 14/129 (10%)

Query: 364  YTSFDTFSWAFLSLFRLMTQDFWENLYQLTLR-----------AAGKTYMIFFVLVIFLG 412
            + +F+ F  AFL+LF++ T D W  + + TLR           +      ++FV  +   
Sbjct: 1658 HATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTA 1717

Query: 413  SFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESR 472
             F LIN+++AV+    ++ N+   E+AE  +AE +  LE         +    +  A  R
Sbjct: 1718 QFVLINVVVAVLMKHLDDSNKEAQEDAEM-DAELE--LEMAHGLGPGPRLPTGSPGAPGR 1774

Query: 473  DFSGAGGIG 481
               GAGG G
Sbjct: 1775 GPGGAGGGG 1783



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 20/93 (21%), Positives = 52/93 (55%), Gaps = 2/93 (2%)

Query: 366 SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
           +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862

Query: 426 MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQE 458
             ++ +  A    +++ ++     +E+  K QE
Sbjct: 863 EGFQAEGDANRSYSDEDQS--SSNIEEFDKLQE 893



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)

Query: 930 HSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFS 987
           ++++++F+V+  E W+E M+  M+ A        F++++++G+  ++NL L ++ + FS
Sbjct: 345 YAWIVIFQVITLEGWVEIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 402


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score =  337 bits (864), Expect = 7e-92
 Identities = 194/611 (31%), Positives = 341/611 (55%), Gaps = 38/611 (6%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R +C K++ H  F+  ++  I L+   +A E   I+   T +  L  ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343

Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLT---ANALGYSELGAIKSLRTLRA 1310
            ++K VA G       Y  ++W  LD L+V VSLV +    A+A G   LG ++ LR LR 
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR  G+++VV  L+ ++  I N++L+C  F++IF I+GV LF GKFY+C    
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC---- 1459

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
              E  D   ++  ++C+A        RW   K NFDN+G   +SL  +++  GW++IMY 
Sbjct: 1460 --EGPDTRNISTKAQCRAA-----HYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYD 1512

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  SFF LN+F+GV+++NF++ ++    ++   
Sbjct: 1513 GLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARR 1572

Query: 1491 TEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMV 1550
             EE  K    +++   K  ++P     +  +  +    T    D+ I  +IC+N++TM +
Sbjct: 1573 REE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSM 1630

Query: 1551 ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGM 1609
            E  +Q + +   L + N VF ++F  E  LKL++  +  +F   WN  D  +V+LS++G+
Sbjct: 1631 EHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGI 1690

Query: 1610 FL--AELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLL 1667
             L   E+     ++PT+ R++R+ RI R+L+L+K A G+R LL  ++ +LP + N+GLL 
Sbjct: 1691 TLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF 1750

Query: 1668 FLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1722
             L+ FIYA  G+  F  ++        G+     F  FG + + LF+++T   W+G++  
Sbjct: 1751 MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKD 1810

Query: 1723 ILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1782
             L     +C  +  H  S +      P++   +FV++++++  V+VN+ +AV++++   +
Sbjct: 1811 TLR----ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES 1860

Query: 1783 TEESAEPLSED 1793
             +E+ E    D
Sbjct: 1861 NKEAREDAELD 1871



 Score =  136 bits (342), Expect = 2e-31
 Identities = 83/262 (31%), Positives = 138/262 (52%), Gaps = 17/262 (6%)

Query: 745  WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
            W+     +  +V   +    I + I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 779  WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838

Query: 805  EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
            EM LK++A  P  Y +  +NIFDG IV +S+ E+      GLSVLR+FRLLRV KL +  
Sbjct: 839  EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898

Query: 865  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIS-----NDCE 919
            P L   + ++  ++  +     +L + +FIF+++GM LFG       CK S      D  
Sbjct: 899  PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDTGDTV 951

Query: 920  LPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLF 978
              R +      + + VF++L  E W   +++ M        L  F+ +M  GN V+ NL 
Sbjct: 952  PDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAAL-YFVALMTFGNYVLFNLL 1010

Query: 979  LALLLSSFSSD---NLAATDDD 997
            +A+L+  F ++   N + TD+D
Sbjct: 1011 VAILVEGFQAEGDANRSDTDED 1032



 Score =  122 bits (306), Expect = 4e-27
 Identities = 90/356 (25%), Positives = 168/356 (47%), Gaps = 37/356 (10%)

Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTK------NVEYTFTGI----YTF 168
           R   ++++ +  F  + M  I+ NCV + M  P +  +      N+   F       +  
Sbjct: 90  RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAV 149

Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
           E +IK++A G   +   +L D WN LDF ++    +   +D  NVS  A+RT RVLR L+
Sbjct: 150 EMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLR 208

Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C     D++
Sbjct: 209 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL---DSA 265

Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALL-CGNSSDAG 345
               N  +F            N  +     D  ++  SH   + G+ +  + C    +A 
Sbjct: 266 FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSH---IPGRRELRMPCTLGWEAY 322

Query: 346 QCPEG-----------------YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWEN 388
             P+                   +C     NP+ G  +FD   +A++++F+++T + W +
Sbjct: 323 TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382

Query: 389 LYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEA 444
           +    + A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++ A
Sbjct: 383 IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRA 438



 Score =  115 bits (287), Expect = 6e-25
 Identities = 94/382 (24%), Positives = 162/382 (42%), Gaps = 93/382 (24%)

Query: 108  ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP---PDWTKNV-----E 159
            ALY+ +P N  R    K++ H +F+ +++  I  NCV + +  P   P  T+ V      
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332

Query: 160  YTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------L 210
            Y FT I+  E ++K++A G    +  +L+  WN LD  ++  + V   V          L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392

Query: 211  GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
            G +  LR  R LR L+ IS  PGLK +V  LI S++ + +++++      +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452

Query: 271  MGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLE 330
             G                                                     FY+ E
Sbjct: 1453 KGK----------------------------------------------------FYYCE 1460

Query: 331  GQNDALLCGNSSDAGQCPEG-YICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENL 389
            G +      N S   QC    Y  V+   N       FD    A +SLF L ++D W N+
Sbjct: 1461 GPDTR----NISTKAQCRAAHYRWVRRKYN-------FDNLGQALMSLFVLSSKDGWVNI 1509

Query: 390  YQLTLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEA 439
                L A G             +++F+  + + SF+++N+ + VV   + +  Q   +EA
Sbjct: 1510 MYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEA 1567

Query: 440  EQKEAEFQQMLEQLKKQQEEAQ 461
            E+     ++ L +L++++ +AQ
Sbjct: 1568 EEARRREEKRLRRLERRRRKAQ 1589



 Score =  110 bits (275), Expect = 1e-23
 Identities = 77/260 (29%), Positives = 127/260 (48%), Gaps = 27/260 (10%)

Query: 760  FVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYF 819
            ++DL IT  I +N + M+MEHY   +     L   N VFT +F  E  LK++A     +F
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1671

Query: 820  QEGWNIFDGFIVSLSLMELGLANVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 869
            ++ WN  D  IV LSLM + L  +E           + ++R  R+ RV KL K    +  
Sbjct: 1672 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1731

Query: 870  LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH--MHD 927
            L+  +  ++  +GNL L+  ++ FI+A +G++LFG+      C   N CE    H    +
Sbjct: 1732 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1787

Query: 928  FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ--TMCLT--------VFMMVMVIGNLVVLN 976
            F  +FL +FRV  G+ W   M D +    +    CL+         F+  +++   V++N
Sbjct: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847

Query: 977  LFLALLLSSFSSDNLAATDD 996
            + +A+L+      N  A +D
Sbjct: 1848 VVVAVLMKHLEESNKEARED 1867



 Score =  102 bits (254), Expect = 4e-21
 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 38/291 (13%)

Query: 1516 PANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTN--ILYWINLVFIVL 1573
            P N+F+      +T ++FD  +++ I LN VT+ +E  D     T    L   N +F  +
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

Query: 1574 FTGECVLKLISL-----RYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVI 1628
            F  E ++K+++L      + Y    WN+ D ++V++S+V + +A           + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398

Query: 1629 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAY 1684
            RL R  R LR+I  A G++ ++  L+ SL  + NI L+      I+ I G+      F Y
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458

Query: 1685 VK----REVG------------IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728
             +    R +             +   +NF+  G +++ LF +++  GW  ++   L++  
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVG 1518

Query: 1729 PDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1779
             D  P ++H          NP + + +F+S+++I    V+NM++ V++ENF
Sbjct: 1519 VDQQPVQNH----------NPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 74/270 (27%), Positives = 132/270 (48%), Gaps = 39/270 (14%)

Query: 755  VVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKII 811
            V+     D  + + I LN + +A+E  P  +  S+    LSV N +FT IF AEM +K++
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALER-PDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348

Query: 812  AMD----PYYYFQEGWNIFDGFIVSLSLMEL-------GLANVEG-LSVLRSFRLLRVFK 859
            A+      + Y Q  WN+ DG +V +SL+++       G A + G L VLR  R LR  +
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408

Query: 860  LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY----------- 907
            +    P L ++++ + +S+  +GN+ L+      IF ++G+QLF GK Y           
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468

Query: 908  KECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------Q 956
             +  C+ ++   + R +  D     L+   VL  +  W+  M+D ++  G          
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHN 1528

Query: 957  TMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986
               L  F+  ++I +  VLN+F+ +++ +F
Sbjct: 1529 PWMLLYFISFLLIVSFFVLNMFVGVVVENF 1558



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 73/289 (25%), Positives = 133/289 (46%), Gaps = 43/289 (14%)

Query: 1191 GKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFT 1250
            G+LW        +IV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT
Sbjct: 776  GRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVFT 833

Query: 1251 YIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +F LEMLLK +A G   Y  N +   D +IV +S+  +   A      G +  LRT R 
Sbjct: 834  SMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFRL 888

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LR L+ +     +R  +  L+  + ++     + ++F  IFSI+G++LF  KF   +   
Sbjct: 889  LRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF--SLKTD 946

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
            TG+                            + NFD++    +++ Q+ T + W  ++Y 
Sbjct: 947  TGDTVP------------------------DRKNFDSLLWAIVTVFQILTQEDWNVVLYN 982

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
             + S           + +  LYFV  + FG++   NL + ++++ F  +
Sbjct: 983  GMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 76/290 (26%), Positives = 133/290 (45%), Gaps = 41/290 (14%)

Query: 1520 FQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECV 1579
            F G +   V  + F   IM+ I +N ++M VE  +Q +E+TN L   N+VF  +F  E +
Sbjct: 782  FSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEML 841

Query: 1580 LKLISL-RYYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGR 1635
            LKL++     Y    +NIFD ++V++S   IVG     L            V+R  R+ R
Sbjct: 842  LKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLR 890

Query: 1636 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFA---YVKREVG-- 1690
            +L+L++    +R  L  L+ ++  +     LL L +FI++I GM  F     +K + G  
Sbjct: 891  VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDT 950

Query: 1691 IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPS 1750
            + D  NF++   +++ +FQI T   W+ +L                       G     S
Sbjct: 951  VPDRKNFDSLLWAIVTVFQILTQEDWNVVL---------------------YNGMASTSS 989

Query: 1751 VGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYE 1800
                +FV+ +     V+ N+ +A+++E F    + +     ED   + +E
Sbjct: 990  WAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFE 1039



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 58/171 (33%), Positives = 92/171 (53%), Gaps = 13/171 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
            R  C ++V + WFE   + +I+L+   L      ED+     +    +LE  D      F
Sbjct: 90   RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147

Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S    + ++RT+R 
Sbjct: 148  AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS----LSAIRTVRV 203

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 204  LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 254



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 39/132 (29%), Positives = 70/132 (53%), Gaps = 13/132 (9%)

Query: 1400 NVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIF 1459
            N  +NFDN+G  ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II 
Sbjct: 356  NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405

Query: 1460 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANK 1519
            GSFF +NL + VI   F++ K++   +   M E++ ++ +    L S            K
Sbjct: 406  GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462

Query: 1520 FQGMVFDFVTKQ 1531
            + G +F  V ++
Sbjct: 463  YVGHIFRKVKRR 474



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 15/166 (9%)

Query: 742 CKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGI 801
           C PW +  H+  LV+M          C+ L  +F   E      +  ++L   +      
Sbjct: 98  CNPWFE--HVSMLVIM--------LNCVTLG-MFRPCEDVECGSERCNILEAFDAFIFAF 146

Query: 802 FTAEMFLKIIAMDPY---YYFQEGWNIFDGFIVSLSLMELGL-ANVEGLSVLRSFRLLRV 857
           F  EM +K++A+  +    Y  + WN  D FIV   +ME  L  +   LS +R+ R+LR 
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206

Query: 858 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
            +     P++ +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 207 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 54/208 (25%), Positives = 100/208 (48%), Gaps = 20/208 (9%)

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
           +I+    F+  IM  IL N + M +     P + T  +E +   FT ++  E L+K+LA 
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847

Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
           G       ++R+P+N  D  ++  + V E V    G +S LRTFR+LR LK +  +P L+
Sbjct: 848 G----PLGYIRNPYNIFDGIIVVIS-VWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902

Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF--MGNLRNKCLQWPPDNSSFEINIT 293
             +  L++++  ++    L +  + +F+++G+ LF    +L+       PD  +F+  + 
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLW 962

Query: 294 SFFN-----NSLDGNGTTFNRTVSIFNW 316
           +           D N   +N   S  +W
Sbjct: 963 AIVTVFQILTQEDWNVVLYNGMASTSSW 990



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 39/173 (22%), Positives = 85/173 (49%), Gaps = 21/173 (12%)

Query: 115  FNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMS--NPP----DWTKNVEYTFTGIYTF 168
            ++P R+    +      ++ I   I  N + M+M   N P    +  K   Y FT ++ F
Sbjct: 1597 YSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVF 1656

Query: 169  ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LR 217
            E+ +K++A GF      F +D WN LD  ++  + +   ++   +SA           +R
Sbjct: 1657 EAALKLVAFGF----RRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMR 1712

Query: 218  TFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
              R+ R LK + +  G++ ++  ++Q++ ++ ++ +L +    ++A +G++LF
Sbjct: 1713 VLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 50/163 (30%), Positives = 78/163 (47%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT+ +    E  +   E  NIL   +      F  E V+K+++L  +
Sbjct: 102  FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +V+  ++   L    + + VS      IR  R+ R LR I    
Sbjct: 162  GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 215  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 257



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 35/118 (29%), Positives = 59/118 (50%), Gaps = 17/118 (14%)

Query: 346  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK------ 399
            +C E   C    R     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1769 ECSEDNPCEGLSR-----HATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCL 1823

Query: 400  TYM-----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQ 452
            +Y+     ++FV  + +  F L+N+++AV+    EE N+   E+AE  +AE +  + Q
Sbjct: 1824 SYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAE-LDAEIELEMAQ 1880



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 22/117 (18%), Positives = 59/117 (50%), Gaps = 2/117 (1%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
            +FD+  WA +++F+++TQ+ W  +    + +      ++FV ++  G++ L NL++A++ 
Sbjct: 956  NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015

Query: 426  MAYEEQNQATLEEAEQKE--AEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGI 480
              ++ +  A   + ++ +    F++   +L++ Q       + A   +    G G +
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLEGRGSL 1072



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 360  NFDNIGYAWIAIFQVITLEGWVDIMYYVMDA---------------------HSFYNFIY 398

Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 399  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score =  333 bits (854), Expect = 1e-90
 Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C++I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
             GE  D   + N S+C     +  + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
            +VTM +E   Q Q +   L   N +F V+F  E V KL++  +  +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
            +G++   L     DCD +           C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1777 ENFSVATEESAE 1788
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  135 bits (340), Expect = 4e-31
 Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)

Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
           W  +      +V   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
           EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK +++ +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
            R +      + + VF++L  E W + +++ M        L  F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960

Query: 980 ALLLSSFSSD 989
           A+L+  F ++
Sbjct: 961 AILVEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)

Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P+N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
           S  +++       L+    T N   S F   +  E+     +S             CG  
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301

Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
               NSS    C    + Y    AG  NP  G  +FD   +A++++F+++T + W ++  
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361

Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
             + A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  114 bits (286), Expect = 7e-25
 Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 426  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
              ++ +      +A + E+E       L    +  +  A  +  E  +   +    +   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 486  SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
            +++    L   +   L        ++  S    +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 546  LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
                   SSPH    +   S ++ RR+SR SL    GRA  +              G   
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114

Query: 592  DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
            +  D+E S+ E+  S   S    HRH      ++ + +++S  LP       +H      
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167

Query: 652  GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
            G  S     +  +++G+L           R  R     +  D  +D  +  +   + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 712  TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
                      R + P C       CL  D    ++     + + L + ++     D  + 
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 767  ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
            + I LN + +AME  P  +  S+    L++ N +FT +F AEM +K++A+   +    Y 
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319

Query: 820  QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
            +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++      L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379

Query: 872  KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
            + + +S+  +GN+ ++      IF ++G+QLF   +  C       I+N  DC     RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439

Query: 924  HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
              H    D     L+   VL  +  W++ M+D ++  G             L  F+  ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 969  IGNLVVLNLFLALLLSSF 986
            I    VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)

Query: 742  CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            CKP+     + + LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
            FT IF  E   K++A     +FQ+ WN  D  IV LS+M + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 908  KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
             +  C  ++ CE    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 963  -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  107 bits (266), Expect = 2e-22
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 110  YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
            YI  P +  R L  +I+ H +F+ +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 213  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 273  NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
                                                                 F+  +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 333  NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 393  TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
             L A G             +++F+  + + +F+++N+ + VV   + +  Q   EE  ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 443  EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
              E +    + K++ +E Q A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
            R  C + V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S      ++RT+R 
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 185  LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
            V  + F   IMI I +N ++M +E  +Q +E+TN L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
            +     V+ N+ +A+++E F  A  ++ +  SE D   F+      D D  + +    L 
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003

Query: 1820 DFAD---ALDPPLLI 1831
            +  +   +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)

Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
            W  +  T  KIV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
             LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891

Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
                              S +       + NFD++    +++ Q+ T + W  ++Y  + 
Sbjct: 892  -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934

Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
            S           + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 935  S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)

Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 346  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 403  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)

Query: 124  KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
            ++LVH L      ++ I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 173  KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 222  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT+ +    E      +   IL   +      F  E V+K+++L  +
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score =  333 bits (854), Expect = 1e-90
 Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C++I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
             GE  D   + N S+C     +  + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
            +VTM +E   Q Q +   L   N +F V+F  E V KL++  +  +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
            +G++   L     DCD +           C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1777 ENFSVATEESAE 1788
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  135 bits (340), Expect = 4e-31
 Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)

Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
           W  +      +V   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
           EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK +++ +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
            R +      + + VF++L  E W + +++ M        L  F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960

Query: 980 ALLLSSFSSD 989
           A+L+  F ++
Sbjct: 961 AILVEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)

Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P+N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
           S  +++       L+    T N   S F   +  E+     +S             CG  
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301

Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
               NSS    C    + Y    AG  NP  G  +FD   +A++++F+++T + W ++  
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361

Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
             + A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  114 bits (286), Expect = 7e-25
 Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 426  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
              ++ +      +A + E+E       L    +  +  A  +  E  +   +    +   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 486  SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
            +++    L   +   L        ++  S    +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 546  LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
                   SSPH    +   S ++ RR+SR SL    GRA  +              G   
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114

Query: 592  DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
            +  D+E S+ E+  S   S    HRH      ++ + +++S  LP       +H      
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167

Query: 652  GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
            G  S     +  +++G+L           R  R     +  D  +D  +  +   + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 712  TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
                      R + P C       CL  D    ++     + + L + ++     D  + 
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 767  ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
            + I LN + +AME  P  +  S+    L++ N +FT +F AEM +K++A+   +    Y 
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319

Query: 820  QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
            +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++      L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379

Query: 872  KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
            + + +S+  +GN+ ++      IF ++G+QLF   +  C       I+N  DC     RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439

Query: 924  HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
              H    D     L+   VL  +  W++ M+D ++  G             L  F+  ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 969  IGNLVVLNLFLALLLSSF 986
            I    VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)

Query: 742  CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            CKP+     + + LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
            FT IF  E   K++A     +FQ+ WN  D  IV LS+M + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 908  KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
             +  C  ++ CE    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 963  -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  107 bits (266), Expect = 2e-22
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 110  YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
            YI  P +  R L  +I+ H +F+ +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 213  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 273  NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
                                                                 F+  +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 333  NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 393  TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
             L A G             +++F+  + + +F+++N+ + VV   + +  Q   EE  ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 443  EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
              E +    + K++ +E Q A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
            R  C + V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S      ++RT+R 
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 185  LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
            V  + F   IMI I +N ++M +E  +Q +E+TN L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
            +     V+ N+ +A+++E F  A  ++ +  SE D   F+      D D  + +    L 
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003

Query: 1820 DFAD---ALDPPLLI 1831
            +  +   +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)

Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
            W  +  T  KIV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
             LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891

Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
                              S +       + NFD++    +++ Q+ T + W  ++Y  + 
Sbjct: 892  -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934

Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
            S           + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 935  S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)

Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 346  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 403  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)

Query: 124  KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
            ++LVH L      ++ I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 173  KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 222  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT+ +    E      +   IL   +      F  E V+K+++L  +
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score =  333 bits (854), Expect = 1e-90
 Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C++I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325

Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1441

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
             GE  D   + N S+C     +  + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1442 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1553

Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1554 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1613

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
            +VTM +E   Q Q +   L   N +F V+F  E V KL++  +  +F   WN  D  +V+
Sbjct: 1614 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1673

Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1674 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1733

Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1734 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1793

Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
            +G++   L     DCD +           C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1794 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1840

Query: 1777 ENFSVATEESAE 1788
            ++   + +E+ E
Sbjct: 1841 KHLEESNKEAKE 1852



 Score =  139 bits (351), Expect = 2e-32
 Identities = 81/269 (30%), Positives = 148/269 (55%), Gaps = 14/269 (5%)

Query: 745  WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
            W  +      +V   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 805  EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
            EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 865  PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
            P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK +++ +   LP
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 922  -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
             R +      + + VF++L  E W + +++ M        L  F+ +M  GN V+ NL +
Sbjct: 902  DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960

Query: 980  ALLLSSFSSDNLAATDD-DNEMNNLQIAV 1007
            A+L+  F ++ ++  +D   +++ +Q+ V
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPV 989



 Score =  122 bits (307), Expect = 3e-27
 Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)

Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P+N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
           S  +++       L+    T N   S F   +  E+     +S             CG  
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301

Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
               NSS    C    + Y    AG  NP  G  +FD   +A++++F+++T + W ++  
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361

Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
             + A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)

Query: 742  CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            CKP+     + + LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +
Sbjct: 1579 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1638

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
            FT IF  E   K++A     +FQ+ WN  D  IV LS+M + L  +E           + 
Sbjct: 1639 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1698

Query: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1699 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1755

Query: 908  KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
             +  C  ++ CE    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1756 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1814

Query: 963  -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1815 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853



 Score =  111 bits (277), Expect = 8e-24
 Identities = 145/686 (21%), Positives = 284/686 (41%), Gaps = 115/686 (16%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 426  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
              ++ +     E +++++A  Q    QL     ++Q   A  S    DF      G    
Sbjct: 965  EGFQAE-----EISKREDASGQLSCIQLPV---DSQGGDANKSESEPDFFSPSLDGDGDR 1016

Query: 486  SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
               +A  +S     EL+           +       +   +   +++     R S  GS 
Sbjct: 1017 KKCLAL-VSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSA 1075

Query: 546  ---LTYEKRF-----SSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI---------- 587
                 +E +      SSPH    +   S ++ RR+SR SL    GRA  +          
Sbjct: 1076 EPGAAHEMKSPPSARSSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERR 1129

Query: 588  ----GSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGK 643
                G   +  D+E S+ E+  S   S    HRH      ++ + +++S  LP       
Sbjct: 1130 SLLSGEGQESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPG 1182

Query: 644  MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
            +H      G  S     +  +++G+L           R  R     +  D  +D  +  +
Sbjct: 1183 LHRTASGRGSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSK 1232

Query: 704  AMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMD 758
               + + +          R + P C       CL  D    ++     + + L + ++  
Sbjct: 1233 GERVRAWI----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITH 1275

Query: 759  PFVDLAITICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDP 815
               D  + + I LN + +AME  P  +  S+    L++ N +FT +F AEM +K++A+  
Sbjct: 1276 KMFDHVVLVIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGW 1334

Query: 816  YY----YFQEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKS 863
             +    Y +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++   
Sbjct: 1335 CFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISR 1394

Query: 864  WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--D 917
               L ++++ + +S+  +GN+ ++      IF ++G+QLF   +  C       I+N  D
Sbjct: 1395 AQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSD 1454

Query: 918  CELP--RWHMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCL 960
            C     RW  H    D     L+   VL  +  W++ M+D ++  G             L
Sbjct: 1455 CAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWML 1514

Query: 961  TVFMMVMVIGNLVVLNLFLALLLSSF 986
              F+  ++I    VLN+F+ +++ +F
Sbjct: 1515 LYFISFLLIVAFFVLNMFVGVVVENF 1540



 Score =  107 bits (266), Expect = 2e-22
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 110  YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
            YI  P +  R L  +I+ H +F+ +++  I  NC+ + M  P     + E        Y 
Sbjct: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316

Query: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

Query: 213  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436

Query: 273  NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
                                                                 F+  +G+
Sbjct: 1437 K----------------------------------------------------FFVCQGE 1444

Query: 333  NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1445 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1494

Query: 393  TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
             L A G             +++F+  + + +F+++N+ + VV   + +  Q   EE  ++
Sbjct: 1495 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1554

Query: 443  EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
              E +    + K++ +E Q A A       D+S
Sbjct: 1555 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1587



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
            R  C + V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S      ++RT+R 
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 185  LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 91.3 bits (225), Expect = 9e-18
 Identities = 68/287 (23%), Positives = 132/287 (45%), Gaps = 44/287 (15%)

Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
            W  +  T  KIV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
             LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891

Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
                              S +       + NFD++    +++ Q+ T + W  ++Y  + 
Sbjct: 892  -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934

Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1480
            S           + +  LYF+  + FG++   NL + ++++ F  ++
Sbjct: 935  S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE 971



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 73/272 (26%), Positives = 124/272 (45%), Gaps = 40/272 (14%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
            V  + F   IMI I +N ++M +E  +Q +E+TN L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLS 1791
            +     V+ N+ +A+++E F        E  S
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)

Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 346  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1758 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1812

Query: 403  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1813 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1870



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)

Query: 124  KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
            ++LVH L      ++ I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1590 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1649

Query: 173  KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1650 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1705

Query: 222  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF
Sbjct: 1706 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT+ +    E      +   IL   +      F  E V+K+++L  +
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score =  333 bits (854), Expect = 1e-90
 Identities = 200/612 (32%), Positives = 341/612 (55%), Gaps = 46/612 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEM 1257
            R  C++I+ H  F+  ++ +I L+   +A E   I+     +  L  ++ +FT +F+ EM
Sbjct: 1243 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1302

Query: 1258 LLKWVAYGF----QVYFTNAWCWLDFLIVDVSLVSLTANAL---GYSELGAIKSLRTLRA 1310
             +K VA G+    Q Y  ++W  LD L+V +S++ +  + +   G   LG ++ LR LR 
Sbjct: 1303 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1362

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYT 1370
            LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF+ C    
Sbjct: 1363 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC---- 1418

Query: 1371 TGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYA 1430
             GE  D   + N S+C     +  + RW   K NFDN+G   +SL  +A+  GW+DIMY 
Sbjct: 1419 QGE--DTRNITNKSDC-----AEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 1431 AVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFM 1490
             +D+  V+ QP    N +M LYF+ F++  +FF LN+F+GV+++NF++ ++    ++   
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEA-R 1530

Query: 1491 TEEQKKYYNAMKKLGSKKPQ------KPIPRPANKFQGMVFDFVTKQVFDISIMILICLN 1544
              E+K+     KK  SK+ Q      KP     ++F+ +V    T    D+ I  +I LN
Sbjct: 1531 RREEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLN 1590

Query: 1545 MVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVI 1603
            +VTM +E   Q Q +   L   N +F V+F  E V KL++  +  +F   WN  D  +V+
Sbjct: 1591 VVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVL 1650

Query: 1604 LSIVGMFLAEL--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
            LSI+G+ L E+       ++PT+ R++R+ RI R+L+L+K A G+R LL  +M +LP + 
Sbjct: 1651 LSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVG 1710

Query: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKRE-----VGIDDMFNFETFGNSMICLFQITTSAGW 1716
            N+GLL  L+ FI+A  G+  F  ++ +      G+     F  FG + + LF+++T   W
Sbjct: 1711 NLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNW 1770

Query: 1717 DGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVIL 1776
            +G++   L     DCD +           C N  +   +FVS+++ +  V+VN+ IAV++
Sbjct: 1771 NGIMKDTLR----DCDQE---------STCYNTVISPIYFVSFVLTAQFVLVNVVIAVLM 1817

Query: 1777 ENFSVATEESAE 1788
            ++   + +E+ E
Sbjct: 1818 KHLEESNKEAKE 1829



 Score =  135 bits (340), Expect = 4e-31
 Identities = 78/250 (31%), Positives = 137/250 (54%), Gaps = 13/250 (5%)

Query: 745 WLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
           W  +      +V   +    I I I++NTL M +E++   E+ ++ L + N+VFT +F  
Sbjct: 729 WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788

Query: 805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSW 864
           EM LK++   P+ Y +  +NIFDG IV +S+ E+      GLSVLR+FRL+RV KL +  
Sbjct: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848

Query: 865 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCE---LP 921
           P L   + ++  ++  +    ++L + +FIF+++GM LFG       CK +++ +   LP
Sbjct: 849 PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFG-------CKFASERDGDTLP 901

Query: 922 -RWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFL 979
            R +      + + VF++L  E W + +++ M        L  F+ +M  GN V+ NL +
Sbjct: 902 DRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAAL-YFIALMTFGNYVLFNLLV 960

Query: 980 ALLLSSFSSD 989
           A+L+  F ++
Sbjct: 961 AILVEGFQAE 970



 Score =  122 bits (307), Expect = 3e-27
 Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 36/355 (10%)

Query: 119 RKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPD----------WTKNVEYTFTGIYTF 168
           R   ++ + +  F  + M  IL NCV + M  P +            +  +      +  
Sbjct: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130

Query: 169 ESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVS--ALRTFRVLRALK 226
           E ++K++A G   +   +L D WN LDF ++    +   +DL NVS  A+RT RVLR L+
Sbjct: 131 EMVVKMVALGIFGKK-CYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR 189

Query: 227 TISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNS 286
            I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LRN+C  + P+N 
Sbjct: 190 AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC--FLPENF 247

Query: 287 SFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIED-----KSHFYFLEGQNDALLCG-- 339
           S  +++       L+    T N   S F   +  E+     +S             CG  
Sbjct: 248 SLPLSV------DLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLD 301

Query: 340 ----NSSDAGQC---PEGYICVKAG-RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQ 391
               NSS    C    + Y    AG  NP  G  +FD   +A++++F+++T + W ++  
Sbjct: 302 YEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMY 361

Query: 392 LTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEF 446
             + A      I+F+L+I +GSF++INL L V+A  + E  Q   +   ++   F
Sbjct: 362 FVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416



 Score =  114 bits (286), Expect = 7e-25
 Identities = 137/678 (20%), Positives = 276/678 (40%), Gaps = 122/678 (17%)

Query: 366  SFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVA 425
            +FD+  WA +++F+++TQ+ W  +    + +      ++F+ ++  G++ L NL++A++ 
Sbjct: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964

Query: 426  MAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSE 485
              ++ +      +A + E+E       L    +  +  A  +  E  +   +    +   
Sbjct: 965  EGFQAEG-----DANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIH 1019

Query: 486  SSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSR 545
            +++    L   +   L        ++  S    +     + +S  S R            
Sbjct: 1020 TAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR------------ 1067

Query: 546  LTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDI--------------GSEN 591
                   SSPH    +   S ++ RR+SR SL    GRA  +              G   
Sbjct: 1068 -------SSPHSPWSA--ASSWTSRRSSRNSL----GRAPSLKRRSPSGERRSLLSGEGQ 1114

Query: 592  DFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCN 651
            +  D+E S+ E+  S   S    HRH      ++ + +++S  LP       +H      
Sbjct: 1115 ESQDEEESSEEERASPAGS---DHRH----RGSLEREAKSSFDLPDTLQVPGLHRTASGR 1167

Query: 652  GVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASIL 711
            G  S     +  +++G+L           R  R     +  D  +D  +  +   + + +
Sbjct: 1168 GSASEHQDCNGKSASGRLA----------RALRPDDPPLDGDDADDEGNLSKGERVRAWI 1217

Query: 712  TNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL-----KVKHLVNLVVMDPFVDLAIT 766
                      R + P C       CL  D    ++     + + L + ++     D  + 
Sbjct: 1218 ----------RARLPAC-------CLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVL 1260

Query: 767  ICIVLNTLFMAMEHYPMTEQFSS---VLSVGNLVFTGIFTAEMFLKIIAMDPYY----YF 819
            + I LN + +AME  P  +  S+    L++ N +FT +F AEM +K++A+   +    Y 
Sbjct: 1261 VIIFLNCITIAMER-PKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYL 1319

Query: 820  QEGWNIFDGFIVSLSLMELGLANVEG--------LSVLRSFRLLRVFKLAKSWPTLNMLI 871
            +  WN+ DG +V +S++++ ++ V          L VLR  R LR  ++      L +++
Sbjct: 1320 RSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVV 1379

Query: 872  KIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKEC----VCKISN--DCELP--RW 923
            + + +S+  +GN+ ++      IF ++G+QLF   +  C       I+N  DC     RW
Sbjct: 1380 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRW 1439

Query: 924  HMH----DFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QTMCLTVFMMVMV 968
              H    D     L+   VL  +  W++ M+D ++  G             L  F+  ++
Sbjct: 1440 VRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLL 1499

Query: 969  IGNLVVLNLFLALLLSSF 986
            I    VLN+F+ +++ +F
Sbjct: 1500 IVAFFVLNMFVGVVVENF 1517



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/279 (29%), Positives = 136/279 (48%), Gaps = 28/279 (10%)

Query: 742  CKPWL----KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLV 797
            CKP+     + + LV+ +    ++DL IT  I LN + MAMEHY   +     L + N +
Sbjct: 1556 CKPYYSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYI 1615

Query: 798  FTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEG----------LS 847
            FT IF  E   K++A     +FQ+ WN  D  IV LS+M + L  +E           + 
Sbjct: 1616 FTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIR 1675

Query: 848  VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 907
            ++R  R+ RV KL K    +  L+  +  ++  +GNL L+  ++ FIFA +G++LFG   
Sbjct: 1676 IMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFG--- 1732

Query: 908  KECVCKISNDCELPRWH--MHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQ-TMCLTV- 962
             +  C  ++ CE    H    +F  +FL +FRV  G+ W   M D +    Q + C    
Sbjct: 1733 -DLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTV 1791

Query: 963  -----FMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDD 996
                 F+  ++    V++N+ +A+L+      N  A ++
Sbjct: 1792 ISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830



 Score =  107 bits (266), Expect = 2e-22
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 110  YILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVE--------YT 161
            YI  P +  R L  +I+ H +F+ +++  I  NC+ + M  P     + E        Y 
Sbjct: 1234 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1293

Query: 162  FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVD---------LGN 212
            FT ++  E  +K++A G+C  +  +LR  WN LD  ++  + +   V          LG 
Sbjct: 1294 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1353

Query: 213  VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 272
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++++      +F ++G+QLF G
Sbjct: 1354 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1413

Query: 273  NLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQ 332
                                                                 F+  +G+
Sbjct: 1414 K----------------------------------------------------FFVCQGE 1421

Query: 333  NDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQL 392
             D     N SD  +    ++  K      Y +   D    A +SLF L ++D W ++   
Sbjct: 1422 -DTRNITNKSDCAEASYRWVRHK------YNF---DNLGQALMSLFVLASKDGWVDIMYD 1471

Query: 393  TLRAAG----------KTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQK 442
             L A G             +++F+  + + +F+++N+ + VV   + +  Q   EE  ++
Sbjct: 1472 GLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARR 1531

Query: 443  EAEFQQMLEQLKKQQEEAQAAAAAASAESRDFS 475
              E +    + K++ +E Q A A       D+S
Sbjct: 1532 REEKRLRRLEKKRRSKEKQMAEAQCKPYYSDYS 1564



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 13/171 (7%)

Query: 1198 RKTCYKIVEHNWFETFIVFMILLSSGALAF----EDIYIEQRKTIKTMLEYADKVFTYIF 1253
            R  C + V + WFE   + +ILL+   L      EDI  + ++  + +  + D +F + F
Sbjct: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF-F 128

Query: 1254 ILEMLLKWVA---YGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA 1310
             +EM++K VA   +G + Y  + W  LDF IV   ++  + +    S      ++RT+R 
Sbjct: 129  AVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS----FSAVRTVRV 184

Query: 1311 LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1361
            LRPLRA++R   MR++V  LL  +P + NVLL+C   + IF I+GV L+AG
Sbjct: 185  LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 84/315 (26%), Positives = 145/315 (46%), Gaps = 47/315 (14%)

Query: 1528 VTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISL-R 1586
            V  + F   IMI I +N ++M +E  +Q +E+TN L   N+VF  LF  E +LKL+    
Sbjct: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799

Query: 1587 YYYFTIGWNIFDFVVVILS---IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGA 1643
            + Y    +NIFD V+V++S   IVG     L            V+R  R+ R+L+L++  
Sbjct: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQGGGL-----------SVLRTFRLMRVLKLVRFL 848

Query: 1644 KGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM----SNFAYVKREVGIDDMFNFET 1699
              ++  L  LM ++  +    +LL L +FI++I GM      FA  +    + D  NF++
Sbjct: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDS 908

Query: 1700 FGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY 1759
               +++ +FQI T   W+ +L                       G     S    +F++ 
Sbjct: 909  LLWAIVTVFQILTQEDWNKVL---------------------YNGMASTSSWAALYFIAL 947

Query: 1760 IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
            +     V+ N+ +A+++E F  A  ++ +  SE D   F+      D D  + +    L 
Sbjct: 948  MTFGNYVLFNLLVAILVEGFQ-AEGDANKSESEPD---FFSPSLDGDGDRKKCLALVSLG 1003

Query: 1820 DFAD---ALDPPLLI 1831
            +  +   +L PPL+I
Sbjct: 1004 EHPELRKSLLPPLII 1018



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 68/286 (23%), Positives = 131/286 (45%), Gaps = 44/286 (15%)

Query: 1194 WWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIF 1253
            W  +  T  KIV+  +F   I+  IL+++ ++  E  Y EQ + +   LE ++ VFT +F
Sbjct: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIE--YHEQPEELTNALEISNIVFTSLF 786

Query: 1254 ILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRP 1313
             LEMLLK + YG   Y  N +   D +IV +S+  +        + G +  LRT R +R 
Sbjct: 787  ALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSVLRTFRLMRV 841

Query: 1314 LRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGE 1373
            L+ +     ++  +  L+  + ++    ++ ++F  IFSI+G++LF  KF          
Sbjct: 842  LKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------- 891

Query: 1374 MFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1433
                              S +       + NFD++    +++ Q+ T + W  ++Y  + 
Sbjct: 892  -----------------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMA 934

Query: 1434 SRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1479
            S           + +  LYF+  + FG++   NL + ++++ F  +
Sbjct: 935  S----------TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970



 Score = 71.2 bits (173), Expect = 9e-12
 Identities = 34/104 (32%), Positives = 61/104 (58%), Gaps = 13/104 (12%)

Query: 1403 VNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSF 1462
            +NFDN+G  ++++ QV T +GW+DIMY  +D+           + Y ++YF++ II GSF
Sbjct: 335  INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH----------SFYNFIYFILLIIVGSF 384

Query: 1463 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            F +NL + VI   F++ K++   +   M E++ ++ +    L S
Sbjct: 385  FMINLCLVVIATQFSETKQR---ESQLMREQRVRFLSNASTLAS 425



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)

Query: 124 KILVHSLFNMLIMCTILTNCVFMTMS---NPPDWTKNVEYT---FTGIYTFESLIKILAR 177
           KI+    F   IM  IL N + M +     P + T  +E +   FT ++  E L+K+L  
Sbjct: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797

Query: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL--GNVSALRTFRVLRALKTISVIPGLK 235
           G     F ++++P+N  D  ++  + V E V    G +S LRTFR++R LK +  +P L+
Sbjct: 798 G----PFGYIKNPYNIFDGVIVVIS-VWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852

Query: 236 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             +  L++++  ++   +L +  + +F+++G+ LF
Sbjct: 853 RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 44/157 (28%), Positives = 80/157 (50%), Gaps = 10/157 (6%)

Query: 756 VMDPFVDLAITICIVLNTLFMAM----EHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
           V +P+ +    + I+LN + + M    E      Q   +L   +      F  EM +K++
Sbjct: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137

Query: 812 AMDPY---YYFQEGWNIFDGFIVSLSLME--LGLANVEGLSVLRSFRLLRVFKLAKSWPT 866
           A+  +    Y  + WN  D FIV   ++E  L L NV   S +R+ R+LR  +     P+
Sbjct: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVS-FSAVRTVRVLRPLRAINRVPS 196

Query: 867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 903
           + +L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 197 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 14/119 (11%)

Query: 346  QCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM--- 402
            +C E + C   GR     + +F  F  AFL+LFR+ T D W  + + TLR   +      
Sbjct: 1735 ECDETHPCEGLGR-----HATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYN 1789

Query: 403  -----IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQ 456
                 I+FV  +    F L+N+++AV+    EE N+   EEAE  EAE +  ++ L  Q
Sbjct: 1790 TVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAE-LEAELELEMKTLSPQ 1847



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 42/169 (24%), Positives = 82/169 (48%), Gaps = 26/169 (15%)

Query: 124  KILVHSL-----FNMLIMCTILTNCVFMTMSNPP------DWTKNVEYTFTGIYTFESLI 172
            ++LVH L      ++ I   I  N V M M +        +  K   Y FT I+  ES+ 
Sbjct: 1567 RLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVF 1626

Query: 173  KILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSA-----------LRTFRV 221
            K++A GF      F +D WN LD  ++  + +   ++   V+A           +R  R+
Sbjct: 1627 KLVAFGFR----RFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRI 1682

Query: 222  LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 270
             R LK + +  G++ ++  ++Q++ ++ ++ +L +    +FA +G++LF
Sbjct: 1683 ARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 47/163 (28%), Positives = 74/163 (45%), Gaps = 15/163 (9%)

Query: 1533 FDISIMILICLNMVTMMV----ETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYY 1588
            F+   M++I LN VT+ +    E      +   IL   +      F  E V+K+++L  +
Sbjct: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142

Query: 1589 ----YFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1644
                Y    WN  DF +VI  ++   L        +    F  +R  R+ R LR I    
Sbjct: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD-------LQNVSFSAVRTVRVLRPLRAINRVP 195

Query: 1645 GIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A + R
Sbjct: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238



 Score = 32.3 bits (72), Expect = 4.8
 Identities = 18/97 (18%), Positives = 40/97 (41%), Gaps = 21/97 (21%)

Query: 1696 NFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFF 1755
            NF+  G + I +FQ+ T  GW  ++  ++++                     +      +
Sbjct: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMDA---------------------HSFYNFIY 374

Query: 1756 FVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSE 1792
            F+  II+    ++N+ + VI   FS   +  ++ + E
Sbjct: 375  FILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 411


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,893,396
Number of Sequences: 37866
Number of extensions: 3179586
Number of successful extensions: 25787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 305
Number of HSP's that attempted gapping in prelim test: 17655
Number of HSP's gapped (non-prelim): 4777
length of query: 2005
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1888
effective length of database: 13,817,196
effective search space: 26086866048
effective search space used: 26086866048
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.