Search of human proteins with 90669191

Search of human proteins with 90669191

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
         (548 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...  1090   0.0  
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...  1082   0.0  
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   377   e-104
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   375   e-104
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          348   6e-96
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       342   5e-94
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   326   4e-89
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   323   2e-88
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          309   4e-84
gi|166064021 solute carrier family 22 (organic anion transporter...   307   2e-83
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          291   1e-78
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       286   3e-77
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       260   2e-69
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           258   1e-68
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          254   2e-67
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        253   2e-67
gi|153791484 putative UST1-like organic anion transporter [Homo ...   253   3e-67
gi|42542386 solute carrier family 22 (organic anion/cation trans...   253   4e-67
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          241   2e-63
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       239   4e-63
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]           229   5e-60
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   221   1e-57
gi|157426885 organic cation transporter like 4 [Homo sapiens]         204   2e-52
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          197   3e-50
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   175   1e-43
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   136   4e-32
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       135   1e-31
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   133   4e-31
gi|24308167 SV2 related protein [Homo sapiens]                        129   5e-30
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   125   1e-28

>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 1090 bits (2820), Expect = 0.0
 Identities = 548/548 (100%), Positives = 548/548 (100%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
           QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180
           HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV
Sbjct: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180

Query: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240
           STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW
Sbjct: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240

Query: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300
           TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH
Sbjct: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300

Query: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360
           CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS
Sbjct: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360

Query: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420
           YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR
Sbjct: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420

Query: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480
           LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA
Sbjct: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480

Query: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 540
           PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE
Sbjct: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 540

Query: 541 MPMKQVQN 548
           MPMKQVQN
Sbjct: 541 MPMKQVQN 548


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 546/548 (99%), Positives = 546/548 (99%), Gaps = 2/548 (0%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH
Sbjct: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
           QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD
Sbjct: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120

Query: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180
           HSEFSSTIATE  WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV
Sbjct: 121 HSEFSSTIATE--WDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 178

Query: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240
           STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW
Sbjct: 179 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 238

Query: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300
           TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH
Sbjct: 239 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 298

Query: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360
           CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS
Sbjct: 299 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 358

Query: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420
           YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR
Sbjct: 359 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 418

Query: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480
           LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA
Sbjct: 419 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 478

Query: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 540
           PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE
Sbjct: 479 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEE 538

Query: 541 MPMKQVQN 548
           MPMKQVQN
Sbjct: 539 MPMKQVQN 546


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  377 bits (969), Expect = e-104
 Identities = 215/550 (39%), Positives = 311/550 (56%), Gaps = 14/550 (2%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
           D+S F STI TE  WDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y
Sbjct: 112 DNSTFPSTIVTE--WDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
           + T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
           ++ G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L 
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGV 357
             AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 417
           +F+YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 418 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 477
               ++  D     T LAV+GK    A+F   +L+T ELYPT++RQTGMG+ + + R+G 
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 478 SLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQ 537
            ++PL ++   ++ S+P   YG + + A+   +LLPET    LP+T+QD+E + APT  +
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKE 529

Query: 538 EEEMPMKQVQ 547
               P K  Q
Sbjct: 530 AGIYPRKGKQ 539


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  375 bits (962), Expect = e-104
 Identities = 211/543 (38%), Positives = 309/543 (56%), Gaps = 14/543 (2%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
           D+S F STI TE  WDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y
Sbjct: 112 DNSTFPSTIVTE--WDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
           + T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
           ++ G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L 
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGV 357
             AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 417
           +F+YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 418 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 477
               ++  D     T LAV+GK    A+F   +L+T ELYPT++RQTGMG+ + + R+G 
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGS 469

Query: 478 SLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQ 537
            ++PL ++   ++ S+P   YG + + A+   +LLPET    LP+T+QD+E +    + Q
Sbjct: 470 IVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRKGKQTRQ 529

Query: 538 EEE 540
           ++E
Sbjct: 530 QQE 532


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  348 bits (894), Expect = 6e-96
 Identities = 203/542 (37%), Positives = 289/542 (53%), Gaps = 24/542 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F E+L++VG  G FQ  +VA+L LP + +  H LL IF AA P H C     P + + 
Sbjct: 1   MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR----PPHNAS 56

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
              W+   LP  P+G    CLRF +P   PN +L  + Q   E        PC  GW Y+
Sbjct: 57  TGPWV---LPMGPNGKPERCLRFVHP---PNASLPNDTQRAME--------PCLDGWVYN 102

Query: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180
            ++ S  I TE  WDLVC    L   A + F AG+L+G +  G LSDRFGRR +L  +Y+
Sbjct: 103 STKDS--IVTE--WDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYL 158

Query: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240
                G  +A S ++ ++ + R L G  ++G T+  + L +EW+    R +        +
Sbjct: 159 LLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCY 218

Query: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300
           T G  +L  + Y I  WRWL L V++P     LS WW PES RWL+  G   +A + L  
Sbjct: 219 TFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRR 278

Query: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYL--DLFRTPRLRHISLCCVVVWFGVN 358
            A  NG+    +  S E +      E  + +  Y   DLFR P LR ++ C  + WF   
Sbjct: 279 VAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATG 338

Query: 359 FSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFG 418
           F+YY L++ V   G+N+Y  Q++FG V++P+K +  LS+ Y GR  TQA  LL    A  
Sbjct: 339 FAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAIL 398

Query: 419 TRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGS 478
               V  D+++  TVLAV GK    ++F+  +L+TSELYPTV+RQTGMG++ L  R+G  
Sbjct: 399 ALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSM 458

Query: 479 LAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQE 538
           ++PL  +   V   +P + YG  ALL    AL LPET    LPETI+D+E  S      +
Sbjct: 459 VSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPK 518

Query: 539 EE 540
           +E
Sbjct: 519 QE 520


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  342 bits (877), Expect = 5e-94
 Identities = 211/560 (37%), Positives = 294/560 (52%), Gaps = 26/560 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+ +G  G FQL + ALL LP  LL  H  L  F AAVP H C  P      S 
Sbjct: 1   MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST 60

Query: 61  QD--VWLEAHLPREPDGTLSSCLRFAYPQ---ALPNTTLGEERQSRGELEDEPATVPCSQ 115
            D   WL A +P +  G    C RF  PQ     PN+++              AT  C  
Sbjct: 61  NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSI-----------PGAATEGCKD 109

Query: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175
           GW Y+ S F STI  E  WDLVCE + L   A + + AGVLVGA  FG L+DR G +  L
Sbjct: 110 GWVYNRSVFPSTIVME--WDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPL 167

Query: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL 235
           + +Y+     G A+A   S+  + + R L G   +G  +  + L +EW+    RTVAG+L
Sbjct: 168 VWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGIL 227

Query: 236 SSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 295
               +T G ++LA V YLIR WR L  A++ P     L  WW+PES+RWLL  G  + A 
Sbjct: 228 LGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAV 287

Query: 296 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLCCVVV 353
           + L   A +NGR    +  ++E +S     E   V    S LDLFRTP +R ++ C +V+
Sbjct: 288 QNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVI 347

Query: 354 WFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGT 413
           WF  + +YYGL++D+   GL++Y  Q LFG +  P+ L+   ++ Y GRR T A  L+  
Sbjct: 348 WFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILA 407

Query: 414 ALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVG 473
            L     + V    +   T  A +GK    ++F   YLFT ELYPT +RQ GMG  ++  
Sbjct: 408 GLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHA 467

Query: 474 RLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERK--- 530
           RLGG  APL   L      LP +++G  A+LA     +L ETR   L ETI  +ER+   
Sbjct: 468 RLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKE 527

Query: 531 -SAPTSLQE--EEMPMKQVQ 547
            S+   ++E  EE+ ++Q++
Sbjct: 528 GSSKKHVEEKSEEISLQQLR 547


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  326 bits (835), Expect = 4e-89
 Identities = 201/550 (36%), Positives = 283/550 (51%), Gaps = 58/550 (10%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
           D+S F STI TE  WDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y
Sbjct: 112 DNSTFPSTIVTE--WDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
           + T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
           ++ G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L 
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGV 357
             AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 417
           +F+YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 418 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 477
               ++  D     T LAV+GK    A+F   +L+T ELYPT++R               
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR--------------- 454

Query: 478 SLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQ 537
                                           +LLPET    LP+T+QD+E + APT  +
Sbjct: 455 -----------------------------AVTVLLPETLGQPLPDTVQDLESRWAPTQKE 485

Query: 538 EEEMPMKQVQ 547
               P K  Q
Sbjct: 486 AGIYPRKGKQ 495


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  323 bits (828), Expect = 2e-88
 Identities = 197/543 (36%), Positives = 281/543 (51%), Gaps = 58/543 (10%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M F +LL+QVGG G FQ   V L+ LP +L+  H  L  F AA+P H C  P A AN S 
Sbjct: 1   MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR-PPADANLS- 58

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQ-ALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           ++  LE  LPR+  G   SCLRF  PQ  LP    G E    G      AT PC+ GW Y
Sbjct: 59  KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLN-GTEANGTG------ATEPCTDGWIY 111

Query: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
           D+S F STI TE  WDLVC  + L + A + +  GVL+GA+ FGYL+DR GRR++L++ Y
Sbjct: 112 DNSTFPSTIVTE--WDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNY 169

Query: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
           + T V G  +A + ++ ++   R L+G ALAG ++  M L +EW+ +  R   G L    
Sbjct: 170 LQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYV 229

Query: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
           ++ G  LLA V Y +  WR L L V+ P     +  W+  ESARW  + G +    R L 
Sbjct: 230 YSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQ 289

Query: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRR--PSYLDLFRTPRLRHISLCCVVVWFGV 357
             AR+NG+       S E +      E  + +   S ++L R P LRH+ LC  ++WF  
Sbjct: 290 RVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFAT 349

Query: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 417
           +F+YYGL +D+ G G+++Y  Q++FGAV+LP+KL+ +L +   GRR  Q   LL   +  
Sbjct: 350 SFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICI 409

Query: 418 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 477
               ++  D     T LAV+GK    A+F   +L+T ELYPT++R               
Sbjct: 410 LLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR--------------- 454

Query: 478 SLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQ 537
                                           +LLPET    LP+T+QD+E +    + Q
Sbjct: 455 -----------------------------AVTVLLPETLGQPLPDTVQDLESRKGKQTRQ 485

Query: 538 EEE 540
           ++E
Sbjct: 486 QQE 488


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  309 bits (792), Expect = 4e-84
 Identities = 200/546 (36%), Positives = 285/546 (52%), Gaps = 27/546 (4%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP---GAPAN 57
           M F ELL+ VGG G FQ+     L +  + L    +L  F AAVP+HRC  P    + A 
Sbjct: 1   MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

Query: 58  FS-----HQDVWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPA 109
            S       +  L   +P  P+     C RF  PQ     PN T             E  
Sbjct: 61  ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSW--------SEAD 112

Query: 110 TVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRF 169
           T PC  GW YD S F+STI   ++W+LVC+   L   A + + AG+LVGA A G  SDRF
Sbjct: 113 TEPCVDGWVYDRSIFTSTIV--AKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRF 170

Query: 170 GRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHR 229
           GRR +L  +Y+   V+G A+A + ++ ++ + R L   A+AG  +    L +EW     R
Sbjct: 171 GRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARAR 230

Query: 230 TVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQG 289
            +   L+S  ++ G  L A V Y +RDW  L L V++P     L  WW+ ESARWLLT G
Sbjct: 231 PLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTG 290

Query: 290 HVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLFRTPRLRHIS 347
            +    + L   A +NG+   +D+ + E +      E  + +P  S   L R P LR  +
Sbjct: 291 RLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRT 350

Query: 348 LCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQA 407
               + WF   F+++GL+LD+  LG N++  Q+  G V++P+K+   L + + GRR T A
Sbjct: 351 CISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLA 410

Query: 408 GTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMG 467
            +LL   L      LV  +M +  + LAV+G     AAFT   +++SEL+PTVLR T +G
Sbjct: 411 ASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVG 470

Query: 468 LTALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 525
           L  +  R G  L PL  LL   G W  LP L YG + +L+   ALLLPET+   LP+TIQ
Sbjct: 471 LGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQ 528

Query: 526 DVERKS 531
           DV+ ++
Sbjct: 529 DVQNQA 534


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  307 bits (786), Expect = 2e-83
 Identities = 189/535 (35%), Positives = 285/535 (53%), Gaps = 18/535 (3%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           F ++L ++G FG FQ++ + LL +   L P +F   +F+     H CA+     +  +  
Sbjct: 4   FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLS 63

Query: 63  V--WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYD 120
               L   +P +  G    CL F  P A  N +L +    R        T PC  GWEY 
Sbjct: 64  AAEQLVLSVPLDTAGHPEPCLMFRPPPA--NASLQDILSHRFN-----ETQPCDMGWEYP 116

Query: 121 HSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYV 180
            +   S    +++++LVC++K L     + F AG+LVG + FG L DR GR+  +L   +
Sbjct: 117 ENRLPSL---KNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLL 173

Query: 181 STLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW 240
              ++GLA+A   S+ ++   R    +A+AG +   + L  EW+    RT A VL+   +
Sbjct: 174 LFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNF 233

Query: 241 TGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLH 300
           + G M+LA + Y  R+WR L +  T P        W +PESARWLLT+G + EA + +  
Sbjct: 234 SLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQK 293

Query: 301 CARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFS 360
            A +N R +  +  +Q    K             LDLFR P+LR ++L    VWF  +  
Sbjct: 294 AASVNRRKLSPELMNQLVPEKTGPSGNA------LDLFRHPQLRKVTLIIFCVWFVDSLG 347

Query: 361 YYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTR 420
           YYGLSL V   GL+VY TQL+FGAVE+P++      ++  GR+ +Q GTL+   L     
Sbjct: 348 YYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIII 407

Query: 421 LLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLA 480
           + + +D+    T+LAV+GK  + AAFT +Y++++EL+PT+LRQTGMGL  +  R+GG L 
Sbjct: 408 IFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILT 467

Query: 481 PLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTS 535
           PL  LL     +LP L YG + ++A     LLPET    L +T+QD+E    P S
Sbjct: 468 PLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRS 522


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  291 bits (744), Expect = 1e-78
 Identities = 187/542 (34%), Positives = 274/542 (50%), Gaps = 20/542 (3%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC---ALPGAPAN 57
           M F +LLEQ GG G FQ   V    LP +++P   LL  F AA+P HRC    L    A 
Sbjct: 1   MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV 60

Query: 58  FSHQD--VWLEAHLPREPDGTLSSCLRFAYPQAL---PNTTLGEERQSRGELEDEPATVP 112
            ++      L   +P  P+     C RF  PQ     PN T             E  T P
Sbjct: 61  STNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSW--------SEADTEP 112

Query: 113 CSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 172
           C  GW YD S F+STI   ++WDLVC  +GL   + + F +G+LVG+  +G LS RFGR+
Sbjct: 113 CVDGWVYDRSVFTSTIV--AKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRK 170

Query: 173 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVA 232
            +L    +   V G ++  + ++V++   R +    +AG  +  + L +EW     R V 
Sbjct: 171 PMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVT 230

Query: 233 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVK 292
             +    ++ G   L  + + +RDWR L LA ++P     L  WW+PESARWL+ +G   
Sbjct: 231 MTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPD 290

Query: 293 EAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCV 351
           +A + L   AR+NG    ++   +  +S V       + P S LDLF  P LR  S   +
Sbjct: 291 QALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAML 350

Query: 352 VVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL 411
           VV F +  SYYGL  D+  LG +++  Q LFGAV+   +    L + + GRR  QAG+  
Sbjct: 351 VVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQA 410

Query: 412 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 471
              LA    +LV  D+++   V AV+GK     + T   ++ +EL+PT +R T  G+   
Sbjct: 411 MAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHT 470

Query: 472 VGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTAL-LLPETRQAQLPETIQDVERK 530
           VGRLG  + PL  +       LP L YG I++ ++   L  LPET+   LP+TIQD+E +
Sbjct: 471 VGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQ 530

Query: 531 SA 532
            +
Sbjct: 531 KS 532


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  286 bits (733), Expect = 3e-77
 Identities = 188/566 (33%), Positives = 278/566 (49%), Gaps = 35/566 (6%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALP-------- 52
           MGF+ LL+QVGG G FQ+  +A   +  +LL  + +L  F A  P+HRC +P        
Sbjct: 1   MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS 60

Query: 53  -GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGE 103
                  S  D+ L   +P + +     C RF +PQ          PNT           
Sbjct: 61  DNDTGTLSKDDL-LRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNT----------- 108

Query: 104 LEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFG 163
             +EP T PC  GW YD S F STI TE  WDLVCE + L     + F AG L+G + +G
Sbjct: 109 --NEPDTEPCVDGWVYDRSSFLSTIVTE--WDLVCESQSLKSMVQSLFMAGSLLGGLIYG 164

Query: 164 YLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEW 223
           +LSDR GR+ +  + ++   +    +A + +++++ I R L G +          L LEW
Sbjct: 165 HLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEW 224

Query: 224 LDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESAR 283
                R++  ++    ++ G MLL  + + I+DW  L L V+ P     LS W + ESAR
Sbjct: 225 TLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESAR 284

Query: 284 WLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTP 341
           WL+    + E  + L   A +NG+   E++ + E V      E   V  + S   LFR P
Sbjct: 285 WLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAP 344

Query: 342 RLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAG 401
           +LR        V F +   +YGL L++  LG NV   Q+L GAV   ++ +  L++ + G
Sbjct: 345 KLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMG 404

Query: 402 RRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVL 461
           RR++Q        L       +  +M+    VLA +G     AA  +A +  +EL PT+L
Sbjct: 405 RRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTIL 464

Query: 462 RQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLP 521
           R T  G+ A+ GR G +LAPL   L      LP ++YG   +LA    LLLPETR   LP
Sbjct: 465 RSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLP 524

Query: 522 ETIQDVERKSAPTSLQEEEMPMKQVQ 547
            TIQDVE +    ++++E+  MK  Q
Sbjct: 525 NTIQDVENEKDSRNIKQEDTCMKVTQ 550


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  260 bits (665), Expect = 2e-69
 Identities = 169/541 (31%), Positives = 264/541 (48%), Gaps = 19/541 (3%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCAL--------P 52
           M FEELL QVGG G FQ+ ++  +    +LL  H LL  F AA+P HRC +         
Sbjct: 1   MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVP 112
           G       +D  L   +P + +     C RF +PQ       G    +      E  T P
Sbjct: 61  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHST-----SEADTEP 115

Query: 113 CSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 172
           C  GW YD S F STI T+  WDLVC+ + L          G+LVG +  G++SDRFGRR
Sbjct: 116 CVDGWVYDQSYFPSTIVTK--WDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRR 173

Query: 173 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTG-SALAGFTIIVMPLELEWLDVEHRTV 231
            +L    +   +    +A + ++ ++ + R L G S++   +   +P+  EW+    + +
Sbjct: 174 FILRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPIT-EWIRPNSKAL 232

Query: 232 AGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHV 291
             +LSS   + G ++L  + Y+ RDW+ L +  ++P     L   W+ ESARWL+    +
Sbjct: 233 VVILSSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKL 292

Query: 292 KEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE--RVVRRPSYLDLFRTPRLRHISLC 349
            E  + L   AR NG    E++ + E V      E      + +  DLFR P +R     
Sbjct: 293 DEGLKALRKVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICI 352

Query: 350 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 409
            V + F     +YG  +++  +G N++  Q+L+GAV L  + L  L++ + GRR++Q   
Sbjct: 353 LVFLRFANTIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILF 412

Query: 410 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469
           +    L+      V  +M++    LA +G   S A F++  +   EL PTVLR    G+ 
Sbjct: 413 MFLVGLSILANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGID 472

Query: 470 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 529
               R+G +LAPL   L   + +LP + YG   ++      LLPET+   LP+TI+DVE 
Sbjct: 473 LTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVEN 532

Query: 530 K 530
           +
Sbjct: 533 Q 533


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  258 bits (658), Expect = 1e-68
 Identities = 177/538 (32%), Positives = 267/538 (49%), Gaps = 26/538 (4%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHF--LLPIFLAAVPAHRCALPGAPANFSH 60
           ++E+   +G +GPFQ   +    L   ++P  F  L  +FL A P HRC +P A AN S 
Sbjct: 4   YDEVTAFLGEWGPFQ--RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDA-ANLS- 59

Query: 61  QDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCS 114
              W    +P   R+      SC R+        + LG E       G+LE E     C 
Sbjct: 60  -SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQES----CL 114

Query: 115 QGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRL 174
            GWE+    + STI TE  W+LVCE         + FF GVL+G+   G LSDRFGR+ +
Sbjct: 115 DGWEFSQDVYLSTIVTE--WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNV 172

Query: 175 LLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGV 234
           L V              S ++ MF +   L G       +    L  E L    R +   
Sbjct: 173 LFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFST 232

Query: 235 LS-STFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKE 293
           L    F+  G M+L L  Y IRDWR LL+A+T+P    +   W++PES RWL++QG  +E
Sbjct: 233 LGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEE 292

Query: 294 AHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVV 353
           A   +   A+ NG  V    F    +  +++ ++  +  + LDL RT  +R +++  +++
Sbjct: 293 AEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ--QSHNILDLLRTWNIRMVTIMSIML 350

Query: 354 WFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLL-- 411
           W  ++  Y+GLSLD   L  +++    L   VE+P+ +L +L ++Y  RR + A  L   
Sbjct: 351 WMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLG 410

Query: 412 GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTAL 471
           G+ L F    LV  D+   +TVL ++GK    AAF+  Y++T+ELYPTV+R  G+G+++ 
Sbjct: 411 GSVLLF--MQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSST 468

Query: 472 VGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVER 529
             RLG  L+P    L      LP +  G + +L A   L LPE+    LP+TI  + R
Sbjct: 469 ASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLR 526


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  254 bits (648), Expect = 2e-67
 Identities = 176/547 (32%), Positives = 264/547 (48%), Gaps = 24/547 (4%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHR-CALPGAPA----- 56
           F+E L++VG FG FQ R   LL L  V     F+  +FL   P H  C  P A A     
Sbjct: 4   FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERC 63

Query: 57  NFSHQDVW---LEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEP----A 109
            +S ++ W     A    EP      C R+    A  + +          L   P     
Sbjct: 64  GWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123

Query: 110 TVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRF 169
            VPC  GW Y  ++  STI +E  +DLVC    +          G L GA   GY +DR+
Sbjct: 124 LVPCRGGWRY--AQAHSTIVSE--FDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRY 179

Query: 170 GRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHR 229
           GR  + L++ +   V G+  A + ++ +F I R L G    G  +    +  E +  + R
Sbjct: 180 GRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQR 239

Query: 230 TVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQG 289
            + G++   F+T G+++L  + Y I +W+ + LA+TLP    +L  W VPES RWL+T+ 
Sbjct: 240 RIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRK 299

Query: 290 HVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLC 349
              +A + L   A+ NG+      +     S++   +  V  PS+LDL RTP++R  +L 
Sbjct: 300 KGDKALQILRRIAKCNGK------YLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLI 353

Query: 350 CVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGT 409
            +  WF     Y GL + +  +G N+Y    + G VELP  LL+ L++   GRRL  A +
Sbjct: 354 LMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS 413

Query: 410 LLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469
            +   +A      +   +    T +A +G+     AF   YL  SELYPT LR  G+ L 
Sbjct: 414 NIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLC 473

Query: 470 ALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
           + +   GG +AP L   L  VWL LP + +G +A +  G  +LLPET+   LPET+ DVE
Sbjct: 474 SGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533

Query: 529 RKSAPTS 535
           +  +P S
Sbjct: 534 KLGSPHS 540


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  253 bits (647), Expect = 2e-67
 Identities = 169/541 (31%), Positives = 266/541 (49%), Gaps = 19/541 (3%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           FE + + VG FG FQ     + A   +   +H+L  +F+   P H C  PG   N S   
Sbjct: 6   FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPG---NVSQVV 62

Query: 63  VWLEAHLPREPDGTLSSCLRFAYPQA-LPNTTLGE-ERQSRGELEDEPAT---------- 110
               ++   E  G L S  +  Y    L N  + E  R SR + E+  +           
Sbjct: 63  FHNHSNWSLEDTGALLSSGQKDYVTVQLQNGEIWELSRCSRNKRENTSSLGYEYTGSKKE 122

Query: 111 VPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFG 170
            PC  G+ YD + + ST  T  QW+LVC++K L       F  GVL+G+V FGY SDR G
Sbjct: 123 FPCVDGYIYDQNTWKSTAVT--QWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLG 180

Query: 171 RRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRT 230
           RR +L     S  + G+A+A +V Y  F   R       +G+ ++     +E++ ++ RT
Sbjct: 181 RRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRT 240

Query: 231 VAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGH 290
            A V   +F+  G +L+AL GYL+R W    + ++    P IL  W +PE+  WLL++G 
Sbjct: 241 WASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETPFWLLSEGR 300

Query: 291 VKEAHRYLLHCARLNGRPVCE--DSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISL 348
            +EA + +   A+ N    C+  +  S +    V+     V++ +   LF    +   +L
Sbjct: 301 YEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTL 360

Query: 349 CCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAG 408
              ++WF  +  +Y  SL+   LG N Y    L G VE+P+   V +++   GRR   A 
Sbjct: 361 TVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAY 420

Query: 409 TLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468
           +L  +ALA G  +++         V A++GK    AAF   YL+T+ELYPT++R   +G 
Sbjct: 421 SLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGS 480

Query: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
            ++V RL   LAP +  L  +W+ +P+L  G +ALL+    L LPET   +L  T ++  
Sbjct: 481 GSMVCRLASILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAA 540

Query: 529 R 529
           +
Sbjct: 541 K 541


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  253 bits (646), Expect = 3e-67
 Identities = 171/548 (31%), Positives = 262/548 (47%), Gaps = 33/548 (6%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
           M F++LL+QVGG G FQ+  +  L +  V++     L  F A +  HRC         +P
Sbjct: 1   MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIP 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
                   QD  L   +P + +     C RF +PQ          PNT+           
Sbjct: 61  DNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTS----------- 109

Query: 105 EDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGY 164
             EP T PC  GW YD S F STI T+  WDLVCE + LN  A   F AG++VG   +G+
Sbjct: 110 --EPDTEPCVDGWVYDQSSFPSTIVTK--WDLVCESQPLNSVAKFLFMAGMMVGGNLYGH 165

Query: 165 LSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWL 224
           LSDRFGR+ +L  +Y+   ++G  +A + + +++   R L G+A     +  + L +EW+
Sbjct: 166 LSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWI 225

Query: 225 DVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARW 284
             +   +A  L+    + G + L  + ++IRD   L L ++ PC    L   W+ ESARW
Sbjct: 226 THQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARW 285

Query: 285 LLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAG--ERVVRRPSYLDLFRTPR 342
           L+     +E  + L   A  NG    ED  + E +        E   ++ S  +L R P 
Sbjct: 286 LIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPN 345

Query: 343 LRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGR 402
           +         V F     ++GL+L +  LG NV+  Q LFGAV L +  +   ++ +  R
Sbjct: 346 ICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSR 405

Query: 403 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 462
           RL+Q   +   A      + V  +M++   VLA +G   +    T +    +EL P+++R
Sbjct: 406 RLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIR 465

Query: 463 QTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPE 522
               G+T     +GG+LA L  +L      LP + YG  A+L+    LLLPETR   L +
Sbjct: 466 GRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLD 525

Query: 523 TIQDVERK 530
           +IQDVE +
Sbjct: 526 SIQDVENE 533


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  253 bits (645), Expect = 4e-67
 Identities = 178/569 (31%), Positives = 269/569 (47%), Gaps = 42/569 (7%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRC--------ALP 52
           M F++LL   G    FQ+     L++  V   LHF+L  F A +P HRC         + 
Sbjct: 1   MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVS 60

Query: 53  GAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQ--------ALPNTTLGEERQSRGEL 104
                   QD  L   +P + +     C RF +PQ          PNT       S  ++
Sbjct: 61  DNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNT-------SDADM 113

Query: 105 EDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGY 164
           E      PC  GW YD   FSSTI TE  WDLVC+ + L   A   F AG++VG +  G+
Sbjct: 114 E------PCVDGWVYDRISFSSTIVTE--WDLVCDSQSLTSVAKFVFMAGMMVGGILGGH 165

Query: 165 LSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWL 224
           LSDRFGRR +L   Y+   ++G  +A + +++++   R L+G A        + L  EW 
Sbjct: 166 LSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEW- 224

Query: 225 DVEHRTVAGVLSSTFWTGGVMLLALVG--YLIRDWRWLLLAVTLPCAPGILSLWWVPESA 282
              HR  A  ++      G+  + L G  + IRDW  L L V++P     L+  W+ ESA
Sbjct: 225 -ATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESA 283

Query: 283 RWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVV---RRPSYLDLFR 339
           RWL+     +E  + L   A  +G     D+ + E +      E      ++PS  ++  
Sbjct: 284 RWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLH 343

Query: 340 TPRL-RHISLCCVVVWFGVNF-SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSV 397
            P + + ISL     +   NF +Y+GL+L V  LG NV+  Q LFGAV L +  +   ++
Sbjct: 344 MPNICKRISLLSFTRF--ANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWAL 401

Query: 398 RYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELY 457
           +Y  RR +Q   +   A+     + V  +M++   VLA +G   S  A T A+   +E+ 
Sbjct: 402 KYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVI 461

Query: 458 PTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQ 517
           PT++R   MG+ A    + G+LAPL  +L      LP + YG    ++    LLLPETR 
Sbjct: 462 PTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRN 521

Query: 518 AQLPETIQDVERKSAPTSLQEEEMPMKQV 546
             L +TIQD + +       ++E P  +V
Sbjct: 522 KPLFDTIQDEKNERKDPREPKQEDPRVEV 550


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  241 bits (614), Expect = 2e-63
 Identities = 177/561 (31%), Positives = 266/561 (47%), Gaps = 41/561 (7%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQD 62
           ++E++  +G +GPFQ     LL+   +    + +  +FLA  P HRC +P A AN S   
Sbjct: 4   YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDA-ANLS--S 60

Query: 63  VWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQ---SRGELEDEPATVPCSQG 116
            W    +P   R+      SC R+        + LG E       G+LE E     C  G
Sbjct: 61  AWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQES----CLDG 116

Query: 117 WEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLL 176
           WE+    + ST+ TE  W+LVCE        ++ FF GVL+G+   G LSDRFGR+ +L 
Sbjct: 117 WEFSQDVYLSTVVTE--WNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174

Query: 177 VAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLS 236
                          S+S+ MF +   + G       ++   L  E L    R +   L 
Sbjct: 175 ATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLG 234

Query: 237 -STFWTGGVMLLALVGYLIRDWRWLLLAVTLP---CAPGILSLWW-VPESARWLLTQGHV 291
             TF+  G MLL L  Y IRDWR LLLA+T+P   C P    LWW +PES RWL++Q   
Sbjct: 235 VCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVP----LWWFIPESPRWLISQRRF 290

Query: 292 KEAHRYLLHCARLNGRPVCEDSF-SQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCC 350
           +EA   +   A++N   V    F S E ++ +   +  +     LDLFRT  +  +++  
Sbjct: 291 REAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFI-----LDLFRTRNIAIMTIMS 345

Query: 351 VVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTL 410
           +++W   +  Y+ LSLD   L  + Y    L   +E+P+ +  +L +R   RR   A  L
Sbjct: 346 LLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVL 405

Query: 411 L--GTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468
              G  L F    LV  D    S  L ++GK    +AF+  Y+FT+ELYPT++R   +G+
Sbjct: 406 FWGGGVLLFIQ--LVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463

Query: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
           T+   R+G  +AP    L      LP +  G + +L     L  PE+    LPET++ ++
Sbjct: 464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQ 523

Query: 529 R-------KSAPTSLQEEEMP 542
           +       K    S++ EE P
Sbjct: 524 KVKWFRSGKKTRDSMETEENP 544


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  239 bits (611), Expect = 4e-63
 Identities = 181/539 (33%), Positives = 266/539 (49%), Gaps = 53/539 (9%)

Query: 1   MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH 60
           M  EE  + VG  G +Q+    LLA   VLL L+        A  A   AL GA  ++ H
Sbjct: 1   MEVEEAFQAVGEMGIYQMYLCFLLA---VLLQLY-------VATEAILIALVGATPSY-H 49

Query: 61  QDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWE-Y 119
            D+                       + LPN + G   QS GE +     +  + G E +
Sbjct: 50  WDL----------------------AELLPNQSHGN--QSAGEDQAFGDWLLTANGSEIH 85

Query: 120 DHSEFSSTIAT-ESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVA 178
            H  FSS+  +  S+W L+  +     AAS+FFF+GV VG ++FG LSDRFGR+++ L  
Sbjct: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145

Query: 179 YVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSST 238
           +   ++  +A+  S SY  FA+TR L G    G +++   L  E +   +  +AG +   
Sbjct: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205

Query: 239 FWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL 298
           F+  G+   AL+GY IR WR L + V L      L   ++PES RWL +QG + EA   L
Sbjct: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265

Query: 299 LHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP-SYLDLFRTPRLRHISLCCVVVWFGV 357
              A+ N +  C  S +  A        R  R   S+LDLFR   L   +L  + +WF  
Sbjct: 266 YLIAKRNRKLKCTFSLTHPA-------NRSCRETGSFLDLFRYRVLLGHTLILMFIWFVC 318

Query: 358 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPS-KLLVYL-SVRYAGRRLTQAGTLL--GT 413
           +  YYGL+L    LG ++Y    L G +E+PS  L +YL + ++ GR+ T +  L   G 
Sbjct: 319 SLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGL 378

Query: 414 ALAFGTRLLVSSDMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLT 469
           A      L    D   ++ V    L+++GK    AAF   Y++TSELYPTV+R  G+G  
Sbjct: 379 ACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTC 438

Query: 470 ALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
           ++  R+GG +AP    L  V  SLP + +G   L +   +LLLPET  + L ET  D++
Sbjct: 439 SMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score =  229 bits (584), Expect = 5e-60
 Identities = 163/553 (29%), Positives = 259/553 (46%), Gaps = 19/553 (3%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LE  G F  FQ +   LLAL        ++  +FL   P HRC  PG  A  S +  
Sbjct: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGV-AELSLRCG 64

Query: 64  WLEAH-----LPRE-PDGTLS--SCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A      +P   P G  S   C R+            +   S           PC  
Sbjct: 65  WSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRD 124

Query: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175
           GW Y+     S+I TE  ++LVC    +     +    G  +G+++ GY++DRFGR+  L
Sbjct: 125 GWVYETP--GSSIVTE--FNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180

Query: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL 235
           L   +     G+  A S +Y    I R + G       +I   L  E++   +R   G+ 
Sbjct: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF 240

Query: 236 SSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 295
               +T G+++LA V Y +  WRWL   V LP    +L  W +PES RWL++Q    EA 
Sbjct: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300

Query: 296 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWF 355
           R + H A+ NG+ +   +  Q    +   G+++   PS+LDL RTP++R  ++  +  WF
Sbjct: 301 RIIKHIAKKNGKSL--PASLQRLRLEEETGKKL--NPSFLDLVRTPQIRKHTMILMYNWF 356

Query: 356 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL 415
             +  Y GL + +   G N+Y        VE P+  ++ L++   GRR   A + +    
Sbjct: 357 TSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGA 416

Query: 416 AFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRL 475
           A    + +  D++    +++ +G+     A+    L  +ELYPT +R  G+ + + +  +
Sbjct: 417 ACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDI 476

Query: 476 GGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPT 534
           GG + P L   L  +WL LP + +G + L+A G  LLLPET+   LPETI++ E    P 
Sbjct: 477 GGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPR 536

Query: 535 SLQEEEMPMKQVQ 547
              +E+M   QVQ
Sbjct: 537 K-NKEKMIYLQVQ 548


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  221 bits (564), Expect = 1e-57
 Identities = 167/551 (30%), Positives = 252/551 (45%), Gaps = 39/551 (7%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LEQVG  G FQ +   +L L         +  +FL   P H C  PG  A  S +  
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63

Query: 64  WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A         L    +  L  C R+         +  +   S           PC  
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175
           GW YD     S+I TE  ++LVC          +   AG L G++  GY +DRFGR+  L
Sbjct: 124 GWVYDTP--GSSIVTE--FNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179

Query: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRT 230
           L   +   V G+  A S +Y+   + R L G       +AG+T+I      E++    R 
Sbjct: 180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRR 234

Query: 231 VAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGH 290
              ++    +T G++ L  + Y +  WRWL LAV+LP    +L  W VPES RWLL+Q  
Sbjct: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294

Query: 291 VKEAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHI 346
             EA + + H A+ NG+    D    S  ++   K++        PS+ DLFRTPRLR  
Sbjct: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKR 346

Query: 347 SLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQ 406
           +   + +WF  +  Y GL L +     N+Y   L    VE+P   +  +++   GR    
Sbjct: 347 TFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPM 406

Query: 407 AGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGM 466
           A + L    A    + +S D+   + ++  +G+     A     L  +ELYPT +R  G+
Sbjct: 407 AMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGV 466

Query: 467 GLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 525
            + + +  +GG + P     L  VW +LP + +  + LLAAG  LLLPET+   LPET++
Sbjct: 467 MVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMK 526

Query: 526 DVE---RKSAP 533
           D E   RK+ P
Sbjct: 527 DAENLGRKAKP 537


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  204 bits (518), Expect = 2e-52
 Identities = 156/541 (28%), Positives = 261/541 (48%), Gaps = 40/541 (7%)

Query: 3   FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSH-- 60
           F  LL+ VG FG FQ R VAL  +P ++         F+       C      A   H  
Sbjct: 52  FANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWILAVGPHLS 111

Query: 61  QDVWLEAHLPREPDGTLSSCLRFA-YPQALPNTTLGEERQSRGELEDEPATVPCSQGWEY 119
           +   L   +P+ P+G+  +C  +   P  L +         +  L D   T  C  GW Y
Sbjct: 112 KAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSII-------QFGLND---TDTCQDGWIY 161

Query: 120 DHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAY 179
             ++  S I   +++DLVC  +     A   F AG+ +G++ F  ++D+ GR   +L++ 
Sbjct: 162 PDAKKRSLI---NEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSL 218

Query: 180 VSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTF 239
           +  ++ G  +A   S+ ++   R     ++ G+ I  + L  EWL  EHR  A +L   F
Sbjct: 219 LGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCF 278

Query: 240 WTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLL 299
           +  G +LL  + Y +  W+ L L   +   P I  +W +PES RWL+ +G VKEA + L 
Sbjct: 279 FAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLC 338

Query: 300 HCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNF 359
           + A +N + +         + ++    + V R S LD  +  +L  ++L    VWF V++
Sbjct: 339 YAASVNKKTI-----PSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSY 393

Query: 360 SYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL---- 415
           +Y+ LSL +  LG++V+   ++   +E+P++L     ++  GR+ + A TLL   +    
Sbjct: 394 TYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLL 453

Query: 416 -------AFGTRL----LVSSDMKSWSTVLAVMGKAFSEAAFTTA-YLFTSELYPTVLRQ 463
                    G RL      ++++KS  T+L +M + FS AA  T  +L+T+EL PTVLR 
Sbjct: 454 LLFLPEGEDGLRLKWPRCPATELKS-MTILVLMLREFSLAATVTVFFLYTAELLPTVLRA 512

Query: 464 TGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPET 523
           TG+GL +L    G  L+    ++      LP      +A++A   + LLPETR   L E+
Sbjct: 513 TGLGLVSLASVAGAILS--LTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQPLSES 570

Query: 524 I 524
           +
Sbjct: 571 L 571


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  197 bits (500), Expect = 3e-50
 Identities = 118/315 (37%), Positives = 172/315 (54%), Gaps = 6/315 (1%)

Query: 221 LEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPE 280
           +EW     R +   L+S  ++ G  L A V Y +RDW  L L V++P     L  WW+ E
Sbjct: 1   MEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAE 60

Query: 281 SARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRP--SYLDLF 338
           SARWLLT G +    + L   A +NG+   +D+ + E +      E  + +P  S   L 
Sbjct: 61  SARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLL 120

Query: 339 RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVR 398
           R P LR  +    + WF   F+++GL+LD+  LG N++  Q+  G V++P+K+   L + 
Sbjct: 121 RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLS 180

Query: 399 YAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYP 458
           + GRR T A +LL   L      LV  +M +  + LAV+G     AAFT   +++SEL+P
Sbjct: 181 HLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFP 240

Query: 459 TVLRQTGMGLTALVGRLGGSLAPLAALL--DGVWLSLPKLTYGGIALLAAGTALLLPETR 516
           TVLR T +GL  +  R G  L PL  LL   G W  LP L YG + +L+   ALLLPET+
Sbjct: 241 TVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPW--LPLLVYGTVPVLSGLAALLLPETQ 298

Query: 517 QAQLPETIQDVERKS 531
              LP+TIQDV+ ++
Sbjct: 299 SLPLPDTIQDVQNQA 313


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  175 bits (443), Expect = 1e-43
 Identities = 138/479 (28%), Positives = 209/479 (43%), Gaps = 35/479 (7%)

Query: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63
           +++LEQVG  G FQ +   +L L         +  +FL   P H C  PG  A  S +  
Sbjct: 5   DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGV-AELSQRCG 63

Query: 64  WLEAH--------LPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115
           W  A         L    +  L  C R+         +  +   S           PC  
Sbjct: 64  WSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQD 123

Query: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175
           GW YD     S+I TE  ++LVC          +   AG L G++  GY +DRFGR+  L
Sbjct: 124 GWVYDTP--GSSIVTE--FNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179

Query: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSA-----LAGFTIIVMPLELEWLDVEHRT 230
           L   +   V G+  A S +Y+   + R L G       +AG+T+I      E++    R 
Sbjct: 180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLIT-----EFVGSGSRR 234

Query: 231 VAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGH 290
              ++    +T G++ L  + Y +  WRWL LAV+LP    +L  W VPES RWLL+Q  
Sbjct: 235 TVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKR 294

Query: 291 VKEAHRYLLHCARLNGRPVCED----SFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHI 346
             EA + + H A+ NG+    D    S  ++   K++        PS+ DLFRTPRLR  
Sbjct: 295 NTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLS--------PSFADLFRTPRLRKR 346

Query: 347 SLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQ 406
           +   + +WF  +  Y GL L +     N+Y   L    VE+P   +  +++   GR    
Sbjct: 347 TFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPM 406

Query: 407 AGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTG 465
           A + L    A    + +S D+   + ++  +G+     A     L  +ELYPT +   G
Sbjct: 407 AMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  136 bits (343), Expect = 4e-32
 Identities = 124/421 (29%), Positives = 187/421 (44%), Gaps = 24/421 (5%)

Query: 126 STIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVL 185
           S  A    W+LVC               G L+G V  G   DRFGRR + + + V T  L
Sbjct: 111 SGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGL 170

Query: 186 GLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVM 245
           G + A + S+    + R L G  LAG  + +    LE  D  HR    + +  F   G +
Sbjct: 171 GASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTL 230

Query: 246 LLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVKEAHRYLLH 300
           LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V  A + L  
Sbjct: 231 LLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWR 288

Query: 301 CARLNGRPVCEDSFSQEAVSK------VAAGERVVRRPSYLDLFRTPRLRHISLCC---V 351
            A  +G    + S  + +++       ++A     R  S L L RT       L      
Sbjct: 289 FAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSS 348

Query: 352 VVWFGVNFSYY-GLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR-LTQAGT 409
           +V  G+  S+   L+  V       Y    L   +E  + + + L+    GRR +   GT
Sbjct: 349 LVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGT 404

Query: 410 LLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGL 468
           ++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV+R  G+GL
Sbjct: 405 MV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGL 463

Query: 469 TALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVE 528
               G LG +  PL  L       L ++ +  +A+LA    LLLPE+R   LP+++QD +
Sbjct: 464 VLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDAD 523

Query: 529 R 529
           R
Sbjct: 524 R 524


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  135 bits (339), Expect = 1e-31
 Identities = 112/430 (26%), Positives = 204/430 (47%), Gaps = 57/430 (13%)

Query: 133 QWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 192
           +W L   Q  L    +T  F G +V ++ FG L+DR+GR ++LL++++      L ++ +
Sbjct: 78  EWQLENWQVAL---VTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFA 134

Query: 193 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLALVG 251
            SY+ F   RT+ G  ++G +  ++ ++ E+L  ++R     LS  FW  G ++++ L  
Sbjct: 135 PSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLAS 193

Query: 252 YLIR--DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 309
            +I    WRWL+   ++P    I++  ++PESAR+ ++ G+ + A   L   A++N   +
Sbjct: 194 VIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVM 253

Query: 310 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVS 369
            E    +  + K         R  + DL     LR  +L   V+W G++F+YYG+ L  +
Sbjct: 254 PEGKLVEPVLEK---------RGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASA 303

Query: 370 GL----------------------------------GLNVYQTQLLFGAVELPSKLLVYL 395
            L                                    + Y+T ++    E+    L  L
Sbjct: 304 ELLERDLVCGSKSDSAVVVTGGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNIL 363

Query: 396 SVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTS 454
            + + GRRL+ + T+  TAL F   LL++    S   +    M +A   A F T Y++T+
Sbjct: 364 GINFLGRRLSLSITMGCTALFF---LLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTA 420

Query: 455 ELYPTVLRQTGMGLTALVGRLGGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLP 513
           E+YPT +R  GMG +  + R+G  +AP ++ +L    +      +  + ++ A +A  LP
Sbjct: 421 EVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 480

Query: 514 -ETRQAQLPE 522
            ET+   L +
Sbjct: 481 IETKGRALQQ 490


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  133 bits (335), Expect = 4e-31
 Identities = 153/549 (27%), Positives = 224/549 (40%), Gaps = 54/549 (9%)

Query: 6   LLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCA-----LPGAPANFSH 60
           +L   GGFG  +    +   +P ++L L       L A PA  C      LP A      
Sbjct: 7   VLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPA-LRALR 65

Query: 61  QDVWLEAHLPR-EPDGTLSSCLRFAY--PQALPNTTLGEERQSRGELEDEPATVPCSQGW 117
               L+A +PR  P    S CL      P  L   T                  P    W
Sbjct: 66  GPALLDAAIPRLGPTRAASPCLPLGVLSPSYLAPLT----------------RAPRPSSW 109

Query: 118 EYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 177
                   S  A    W+LVC               G L+G V  G   DRFGRR + + 
Sbjct: 110 AS-----CSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVA 164

Query: 178 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 237
           + V T  LG + A + S+    + R L G  LAG  + +    LE  D  HR    + + 
Sbjct: 165 SLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAG 224

Query: 238 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWW-----VPESARWLLTQGHVK 292
            F   G +LL  +  L++DWR  LL        G+L L+W      PES  WLL  G V 
Sbjct: 225 LFSVVGTLLLPGLAALVQDWR--LLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVA 282

Query: 293 EAHRYLLHCARLNGRPVCEDSFSQEA------VSKVAAGERVVRRPSYLDLFRTP---RL 343
            A + L   A  +G    + S  + +      ++ ++A     R  S L L RT    R 
Sbjct: 283 RARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRN 342

Query: 344 RHISLCCVVVWFGVNFSY-YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGR 402
             I     +V  G+  S+   L+  V       Y    L   +E  + + + L+    GR
Sbjct: 343 GLILGFSSLVGGGIRASFRRSLAPQVP----TFYLPYFLEAGLEAAALVFLLLTADCCGR 398

Query: 403 R-LTQAGTLLGTALAFGTRLLVSSDMKSWSTV-LAVMGKAFSEAAFTTAYLFTSELYPTV 460
           R +   GT++ T LA    L  +  +  W+ + L+V+G   S A    + LF +E++PTV
Sbjct: 399 RPVLLLGTMV-TGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTV 457

Query: 461 LRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQL 520
           +R  G+GL    G LG +   L  L       L ++ +  +A+LA    LLLPE+R   L
Sbjct: 458 IRGAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGL 517

Query: 521 PETIQDVER 529
           P+++QD +R
Sbjct: 518 PQSLQDADR 526


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  129 bits (325), Expect = 5e-30
 Identities = 120/425 (28%), Positives = 185/425 (43%), Gaps = 52/425 (12%)

Query: 133 QWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 192
           +W L   Q  L    ++  F G++  +  +G +SD++GR+  L ++ + TL  G+ SA +
Sbjct: 114 EWRLPSWQVAL---LTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFA 170

Query: 193 VSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGY 252
             Y    + R L G  + G    V  L  E+L ++ R    +L   FW  G +   ++  
Sbjct: 171 PVYSWILVLRGLVGFGIGGVPQSVT-LYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAV 229

Query: 253 LIRD---WRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPV 309
            +     WRWLL+   +P     +  +W+PESAR+ +  G+ ++A   L   A  NG P+
Sbjct: 230 FVMPSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPM 289

Query: 310 CEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSL--- 366
                    + K+    R   R    DLF TP  R  +L    +WF   FSYYGL L   
Sbjct: 290 --------PLGKLIIS-RQEDRGKMRDLF-TPHFRWTTLLLWFIWFSNAFSYYGLVLLTT 339

Query: 367 ------DVSGLGLNV------------------YQTQLLFGAVELPSKLLVYLSVRYAGR 402
                 DV G+                      Y   L     E P  L+    +   GR
Sbjct: 340 ELFQAGDVCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGR 399

Query: 403 RLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLR 462
           + T A  L     +F + LL     ++  T+L  + +AF    F  AY++T E+YPT  R
Sbjct: 400 KKTMA--LCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYVYTPEVYPTATR 457

Query: 463 QTGMGLTALVGRLGGSLAPLAA---LLDGVWLSLPKLTYGGIALLAAGTALLLP-ETRQA 518
             G+G  + + R+G  + P  A   L   V+L+L    Y G  LLAA  +  LP ET+  
Sbjct: 458 ALGLGTCSGMARVGALITPFIAQVMLESSVYLTL--AVYSGCCLLAALASCFLPIETKGR 515

Query: 519 QLPET 523
            L E+
Sbjct: 516 GLQES 520


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  125 bits (314), Expect = 1e-28
 Identities = 122/442 (27%), Positives = 192/442 (43%), Gaps = 26/442 (5%)

Query: 113 CSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRR 172
           C + W+Y+     +T A   QWDLVC+           F  G   G +  GY +DRFGRR
Sbjct: 70  CLKDWDYNGLPVLTTNAI-GQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRR 128

Query: 173 RLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVA 232
            ++L+        G+  AA+ S       R L G  LAG  + V  + LE  D   R   
Sbjct: 129 GIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRV 188

Query: 233 GVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLW--WVPESARWLLTQGH 290
            +       GG  L   +  + +DWR+L   +T PC   +   W     ESARWL+ +  
Sbjct: 189 ALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQ 248

Query: 291 VKEAH---RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHIS 347
           ++EA    R L    R +G+ + E+  +QEA+  +   E     P+         L + +
Sbjct: 249 IEEAQSVLRILAERNRPHGQMLGEE--AQEALQDL---ENTCPLPATSSFSFASLLNYRN 303

Query: 348 LCCVVVWFG-VNFSYYGL-----SLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAG 401
           +   ++  G  NF  + +      +   G   + Y   LL       + + + ++V   G
Sbjct: 304 IWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFG 363

Query: 402 RRLTQAGTLLGTALAFGTRLLVSSDM-----KSWSTVLAVMGKAFSEAAFTTAYLFTSEL 456
           RR    G LL +    G   LV   +     ++  T  +V+G   S+AA   + L  +E+
Sbjct: 364 RR----GILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEV 419

Query: 457 YPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETR 516
            PT +R  G+GL   +G LGG   P   L  G    L  +     ALL   + +LLPET+
Sbjct: 420 IPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETK 479

Query: 517 QAQLPETIQDVERKSAPTSLQE 538
           +  LPE ++D E    P+ L++
Sbjct: 480 RKLLPEVLRDGELCRRPSLLRQ 501


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,216,802
Number of Sequences: 37866
Number of extensions: 909812
Number of successful extensions: 2280
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2076
Number of HSP's gapped (non-prelim): 93
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.