Search of human proteins with 14149987

Search of human proteins with 14149987

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14149987 WD repeat domain 24 [Homo sapiens]
         (790 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14149987 WD repeat domain 24 [Homo sapiens]                       1649   0.0  
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              86   2e-16
gi|5902034 periodic tryptophan protein 1 [Homo sapiens]                76   1e-13
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               76   1e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     75   3e-13
gi|58331266 WD repeat domain 59 [Homo sapiens]                         73   1e-12
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      66   1e-10
gi|113865883 WD repeat domain 38 [Homo sapiens]                        65   2e-10
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             65   2e-10
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    64   7e-10
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    62   2e-09
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    62   2e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    60   8e-09
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    59   1e-08
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     59   1e-08
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    59   2e-08
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             58   3e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             58   3e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             58   3e-08
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    57   9e-08
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    57   9e-08
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    57   9e-08
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               57   9e-08
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               57   9e-08
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    57   9e-08
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    55   3e-07
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    55   3e-07
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    55   3e-07
gi|16554629 WD repeat domain 5 [Homo sapiens]                          55   3e-07
gi|16554627 WD repeat domain 5 [Homo sapiens]                          55   3e-07

>gi|14149987 WD repeat domain 24 [Homo sapiens]
          Length = 790

 Score = 1649 bits (4271), Expect = 0.0
 Identities = 790/790 (100%), Positives = 790/790 (100%)

Query: 1   MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFV 60
           MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFV
Sbjct: 1   MEKMSRVTTALGGSVLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFV 60

Query: 61  EKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHK 120
           EKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHK
Sbjct: 61  EKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHK 120

Query: 121 RTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFA 180
           RTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFA
Sbjct: 121 RTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFA 180

Query: 181 STFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTH 240
           STFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTH
Sbjct: 181 STFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTH 240

Query: 241 RAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVT 300
           RAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVT
Sbjct: 241 RAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVT 300

Query: 301 TGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLV 360
           TGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLV
Sbjct: 301 TGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLV 360

Query: 361 AAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYA 420
           AAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYA
Sbjct: 361 AAESGRKPYTGDRRHPIFFKRKLDPAEPFAGLASSALSVFETEPGGGGMRWFVDTAERYA 420

Query: 421 LAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLP 480
           LAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLP
Sbjct: 421 LAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVPTANLNHSVGKGGSCGLP 480

Query: 481 LMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLL 540
           LMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLL
Sbjct: 481 LMNSFNLKDMAPGLGSETRLDRSKGDARSDTVLLDSSATLITNEDNEETEGSDVPADYLL 540

Query: 541 GDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGS 600
           GDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGS
Sbjct: 541 GDVEGEEDELYLLDPEHAHPEDPECVLPQEAFPLRHEIVDTPPGPEHLQDKADSPHVSGS 600

Query: 601 EADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVL 660
           EADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVL
Sbjct: 601 EADVASLAPVDSSFSLLSVSHALYDSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVL 660

Query: 661 GERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCS 720
           GERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCS
Sbjct: 661 GERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCS 720

Query: 721 HCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCP 780
           HCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCP
Sbjct: 721 HCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCP 780

Query: 781 AGCGHLCEYS 790
           AGCGHLCEYS
Sbjct: 781 AGCGHLCEYS 790


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 62/244 (25%), Positives = 107/244 (43%), Gaps = 6/244 (2%)

Query: 61  EKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHK 120
           ++  LR+ R    N    DV W + +E++L T + +G +  W+  + +   Q  ++ EH 
Sbjct: 54  DEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQ--VYKEHA 111

Query: 121 RTVNKVCFHPTEAHVLL-SGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTF 179
           + V  V +  T    L+ SGS D  +K +D     S+ TF G    +    +S      F
Sbjct: 112 QEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCF 171

Query: 180 ASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTT 239
           AS   +  +++WD++       +  AH   +  CDW   +   L TG  D  ++ WD+  
Sbjct: 172 ASASGDQTLRIWDVKAAG-VRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRN 230

Query: 240 HRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDV 299
            R      +    ++ RVK+ P     LA+CS   D  +  W+  +P       E H + 
Sbjct: 231 VRQPVFELLGHTYAIRRVKFSPFHASVLASCS--YDFTVRFWNFSKPDSLLETVEHHTEF 288

Query: 300 TTGI 303
           T G+
Sbjct: 289 TCGL 292



 Score = 37.4 bits (85), Expect = 0.055
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 2/67 (2%)

Query: 257 VKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLS 316
           V W     H L TCS   D ++ +WD  +   P  +++EH      + W        ++S
Sbjct: 73  VTWSENNEHVLITCSG--DGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVS 130

Query: 317 GSKDSSL 323
           GS D ++
Sbjct: 131 GSWDQTV 137


>gi|5902034 periodic tryptophan protein 1 [Homo sapiens]
          Length = 501

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 57/173 (32%), Positives = 85/173 (49%), Gaps = 14/173 (8%)

Query: 79  DVVWHQMDENLLATAATNGVVVTWN--LGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVL 136
           D+ W+++  N+LA+A+ +  V+ W+  LG+P+ +        H   V  + FHP EA  L
Sbjct: 261 DLSWNKLIRNVLASASADNTVILWDMSLGKPAAS-----LAVHTDKVQTLQFHPFEAQTL 315

Query: 137 LSGSQDGFMKCFDLRRKDS---VSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDI 193
           +SGS D  +  +D R  D    +  FSGQ E V    FS   +   AST ++G V   D 
Sbjct: 316 ISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHFL--AST-DDGFVYNLDA 372

Query: 194 RRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMH 246
           R  D+      AHN  +   D   + +G L T   DK VK+WD+   R   +H
Sbjct: 373 RS-DKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDILGDRPSLVH 424



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 45/200 (22%), Positives = 73/200 (36%), Gaps = 29/200 (14%)

Query: 188 VQLWDIRRPDRCERMFT--------------------AHNGPVFCCDWHPEDRGWLATGG 227
           +++WD+   D  E +FT                     H   V    W+   R  LA+  
Sbjct: 217 IEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKLIRNVLASAS 276

Query: 228 RDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPF 287
            D  V +WDM+  +      V T   V  +++ P     L + S   D ++ ++D R P 
Sbjct: 277 ADNTVILWDMSLGKPAASLAVHT-DKVQTLQFHPFEAQTLISGS--YDKSVALYDCRSPD 333

Query: 288 VPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQHLFRDASQPVERANPEG-LCYG 346
               M+     +   + W H     FL   S D     +L   + +P+   N       G
Sbjct: 334 ESHRMWRFSGQIER-VTWNHFSPCHFL--ASTDDGFVYNLDARSDKPIFTLNAHNDEISG 390

Query: 347 LFGDLAFAAKESLVAAESGR 366
           L  DL+   K  LV A + +
Sbjct: 391 L--DLSSQIKGCLVTASADK 408


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 61/241 (25%), Positives = 104/241 (43%), Gaps = 16/241 (6%)

Query: 90  LATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFD 149
           L T A++G    WN         + +   H   V  + +   +   +L+    G++K + 
Sbjct: 134 LVTGASSGEFTLWN---GLTFNFETILQAHDSPVRAMTWSHNDMW-MLTADHGGYVKYWQ 189

Query: 150 LRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGP 209
               ++V  F    E++R+  FS  D   FA+  ++G V++WD  R    ER+   H   
Sbjct: 190 -SNMNNVKMFQAHKEAIREASFSPTDN-KFATCSDDGTVRIWDFLRCHE-ERILRGHGAD 246

Query: 210 VFCCDWHPEDRGWLATGGRDKM--VKVWDMTTHRA-KEMHCVQTIASVARVKWRPECRHH 266
           V C DWHP  +G + +G +D    +K WD  T ++   +H  +      ++       + 
Sbjct: 247 VKCVDWHPT-KGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG---NW 302

Query: 267 LATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQH 326
           L T S   DH   ++D+R       +F  H+   T +AW   H+  F   GS  S L  H
Sbjct: 303 LLTASR--DHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360

Query: 327 L 327
           +
Sbjct: 361 V 361



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 43/173 (24%), Positives = 71/173 (41%), Gaps = 11/173 (6%)

Query: 66  RVGRKPSLNLSCADVVWHQMDENLLATAATNGV--VVTWNLGRPSRNKQDQLFTEHKRTV 123
           R+ R    ++ C D  WH   + L+ + + +    +  W+   P   +       HK TV
Sbjct: 238 RILRGHGADVKCVD--WHPT-KGLVVSGSKDSQQPIKFWD---PKTGQSLATLHAHKNTV 291

Query: 124 NKVCFHPTEAHVLLSGSQDGFMKCFDLRR-KDSVSTFSGQSESVRDVQFSIRDYFTFAST 182
            +V  +    + LL+ S+D   K FD+R  K+ +  F G  +    V +       FAS 
Sbjct: 292 MEVKLN-LNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASG 350

Query: 183 FENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
             +G++  W +        M  AH G ++   WHP     L +G  D   K W
Sbjct: 351 GSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGH-ILCSGSNDHTSKFW 402


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 58/202 (28%), Positives = 98/202 (48%), Gaps = 12/202 (5%)

Query: 87  ENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMK 146
           E L+   + +G +  W+L      K  +    HK  +  + FHP    V  SGSQD  +K
Sbjct: 75  EELIVAGSQSGSIRVWDL---EAAKILRTLMGHKANICSLDFHPYGEFVA-SGSQDTNIK 130

Query: 147 CFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAH 206
            +D+RRK  V  + G S++VR ++FS  D    AS  ++  V+LWD+    +    F  H
Sbjct: 131 LWDIRRKGCVFRYRGHSQAVRCLRFS-PDGKWLASAADDHTVKLWDL-TAGKMMSEFPGH 188

Query: 207 NGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQ-TIASVARVKWRPECRH 265
            GPV   ++HP +   LA+G  D+ ++ WD+   + + + C++     V  V + P+   
Sbjct: 189 TGPVNVVEFHPNEY-LLASGSSDRTIRFWDL--EKFQVVSCIEGEPGPVRSVLFNPDGCC 245

Query: 266 HLATCSMMVDHNIYVWDVRRPF 287
             + C   +   +Y W+  R F
Sbjct: 246 LYSGCQDSL--RVYGWEPERCF 265



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 56/197 (28%), Positives = 92/197 (46%), Gaps = 11/197 (5%)

Query: 89  LLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCF 148
           LLAT   +  V  W++ +P+        T H   V  V  +  E  ++++GSQ G ++ +
Sbjct: 35  LLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESVRLNTPE-ELIVAGSQSGSIRVW 90

Query: 149 DLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNG 208
           DL     + T  G   ++  + F     F  AS  ++ N++LWDIRR   C   +  H+ 
Sbjct: 91  DLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKG-CVFRYRGHSQ 148

Query: 209 PVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLA 268
            V C  + P+ + WLA+   D  VK+WD+T  +        T   V  V++ P   + LA
Sbjct: 149 AVRCLRFSPDGK-WLASAADDHTVKLWDLTAGKMMSEFPGHT-GPVNVVEFHPN-EYLLA 205

Query: 269 TCSMMVDHNIYVWDVRR 285
           + S   D  I  WD+ +
Sbjct: 206 SGSS--DRTIRFWDLEK 220


>gi|58331266 WD repeat domain 59 [Homo sapiens]
          Length = 974

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 42/128 (32%), Positives = 59/128 (46%), Gaps = 9/128 (7%)

Query: 662 ERVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQASTTLH--VNC 719
           +R+    + Q  + +   Y ++L R+ L     EV+K      VSC       +   V C
Sbjct: 848 KRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKF-----VSCPPDPHKGIEFGVYC 902

Query: 720 SHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHC 779
           SHC+  +  RG  C  C      CA+CH  V+G   +C  C HGGH  H+M+W      C
Sbjct: 903 SHCRSEV--RGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEWFRTQEVC 960

Query: 780 PAGCGHLC 787
           P GCG  C
Sbjct: 961 PTGCGCHC 968



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 73/305 (23%), Positives = 134/305 (43%), Gaps = 25/305 (8%)

Query: 26  DAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQM 85
           D+ A A+SV       V++GR    +Y +  +   E  + ++ R+   ++    V W+  
Sbjct: 16  DSQATAMSVDCLGQHAVLSGRRF--LYIVNLDAPFEG-HRKISRQSKWDIGA--VQWNPH 70

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D      AA++   V     +    +       H R ++ + +   E  +L++ S D ++
Sbjct: 71  DSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYI 130

Query: 146 KCFDLR--RKDSV--STFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCER 201
             +D++  RK +V  S  +G S+    V+++ ++    A T  +G+V++WD R+P     
Sbjct: 131 YIWDIKDTRKPTVALSAVAGASQ----VKWNKKNANCLA-TSHDGDVRIWDKRKPSTAVE 185

Query: 202 MFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRP 261
              AH   +   DWHP+    LAT  +D  VK WD    R K ++ +     V + ++ P
Sbjct: 186 YLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPR-KYLNILPCQVPVWKARYTP 244

Query: 262 ECRHHLATC---SMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGS 318
              + L T     +  ++++ +W+V     P   F  H DV     WR   +      GS
Sbjct: 245 -FSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKE------GS 297

Query: 319 KDSSL 323
           KD  L
Sbjct: 298 KDYQL 302


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 24/171 (14%)

Query: 116 FTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDS----VSTFSGQSESVRDVQF 171
           F  H R+V  + + PTE  V  S S D  ++ +D+R   S    ++T +     V  + +
Sbjct: 257 FVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISW 316

Query: 172 SIRDYFTFASTFENGNVQLWDIR--RPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRD 229
           S R+ F  +   ++G +++WD+R  +       F  H  PV   +WHP+D G  A  G D
Sbjct: 317 SRREPFLLSGG-DDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGAD 375

Query: 230 KMVKVWDMTTHRAKEMHCVQTIASVA-----------------RVKWRPEC 263
             +  WD+   R  E   V+    +A                  + W P+C
Sbjct: 376 HQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQC 426



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 41/129 (31%), Positives = 53/129 (41%), Gaps = 14/129 (10%)

Query: 203 FTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT---THRAKEMHCVQTIASVARVKW 259
           F  H G  F  DW P   G L TG   K + +W  T   +    +   V    SV  ++W
Sbjct: 210 FAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQW 269

Query: 260 RPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMF---EEHRDVTTGIAW--RHPHDPSFL 314
            P      A+CS   D +I +WD+R     A M      H      I+W  R P    FL
Sbjct: 270 SPTENTVFASCS--ADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREP----FL 323

Query: 315 LSGSKDSSL 323
           LSG  D +L
Sbjct: 324 LSGGDDGAL 332



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 50/217 (23%), Positives = 78/217 (35%), Gaps = 37/217 (17%)

Query: 140 SQDGFMKCFDLRRK-DSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDR 198
           S+ G ++ F LRR    V      +  +RD Q  ++  F+FA     G    W  R   R
Sbjct: 170 SEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGR 229

Query: 199 C-----------------------ERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
                                   +R F  H   V    W P +    A+   D  +++W
Sbjct: 230 LLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIW 289

Query: 236 DMTTHRAKEMHCVQTIAS-----VARVKWRPECRHHLATCSMMVDHNIYVWDVR--RPFV 288
           D+    +K   C+ T A+     V  + W    R      S   D  + +WD+R  +   
Sbjct: 290 DIRAAPSKA--CMLTTATAHDGDVNVISW---SRREPFLLSGGDDGALKIWDLRQFKSGS 344

Query: 289 PAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSLCQ 325
           P A F++H    T + W HP D     +   D  + Q
Sbjct: 345 PVATFKQHVAPVTSVEW-HPQDSGVFAASGADHQITQ 380


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 60/210 (28%), Positives = 98/210 (46%), Gaps = 9/210 (4%)

Query: 114 QLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSI 173
           + F +H   VN   F P +  +LL+GS+DG +  ++ R    +    G +  V+  +FS 
Sbjct: 15  KFFGQHGGEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFS- 72

Query: 174 RDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVK 233
            D   FAS   +  V+LWD+ R  +C R+   H   V    + P+ R  LA+GG DK V 
Sbjct: 73  PDGHLFASASCDCTVRLWDVARA-KCLRVLKGHQRSVETVSFSPDSR-QLASGGWDKRVM 130

Query: 234 VWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMF 293
           +WD+ + +   +  V    S+    + P   + LAT S   D  +++WD+R    PA   
Sbjct: 131 LWDVQSGQMLRL-LVGHRDSIQSSDFSPTV-NCLATGSW--DSTVHIWDLRM-VTPAVSH 185

Query: 294 EEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           +     +  I+         L SGS D ++
Sbjct: 186 QALEGHSANISCLCYSASGLLASGSWDKTI 215



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 48/214 (22%), Positives = 83/214 (38%), Gaps = 52/214 (24%)

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D +L A+A+ +  V  W++ R    K  ++   H+R+V  V F P ++  L SG  D  +
Sbjct: 74  DGHLFASASCDCTVRLWDVARA---KCLRVLKGHQRSVETVSFSP-DSRQLASGGWDKRV 129

Query: 146 KCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRR--PDRCERMF 203
             +D++    +    G  +S++   FS         ++++  V +WD+R   P    +  
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDS-TVHIWDLRMVTPAVSHQAL 188

Query: 204 TAHNGPVFCCD------------------WHPE----------------------DRGWL 223
             H+  + C                    W P                       D  WL
Sbjct: 189 EGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWL 248

Query: 224 ATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARV 257
           A+ G  +MVKVWD  T +     C++T+  V  V
Sbjct: 249 ASAGYSRMVKVWDCNTGK-----CLETLKGVLDV 277


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 39/173 (22%), Positives = 76/173 (43%), Gaps = 14/173 (8%)

Query: 79  DVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLS 138
           DV WH + E+L  + A +  ++ W+    + +K   L   H   VN + F+P    +L +
Sbjct: 231 DVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILAT 290

Query: 139 GSQDGFMKCFDLRR-KDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPD 197
           GS D  +  +DLR  K  + TF    + +  V +S  +    AS+  +  + +WD+ +  
Sbjct: 291 GSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIG 350

Query: 198 RCERMFTAHNGP-------------VFCCDWHPEDRGWLATGGRDKMVKVWDM 237
             +    A +GP             +    W+P +   + +   D ++++W M
Sbjct: 351 EEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 49/223 (21%), Positives = 89/223 (39%), Gaps = 21/223 (9%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H+  VN+  + P   H++ + +    +  FD  +  +    SG+      ++   ++ + 
Sbjct: 122 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 181

Query: 179 FA----------STFENGNVQLWDIRRPDR------CERMFTAHNGPVFCCDWHPEDRGW 222
            +          S  ++  V LWDI    +       + +FT H+  V    WH      
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241

Query: 223 LATGGRDKMVKVWDMTTHR-AKEMHCVQT-IASVARVKWRPECRHHLATCSMMVDHNIYV 280
             +   D+ + +WD  ++  +K  H V    A V  + + P     LAT S   D  + +
Sbjct: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS--ADKTVAL 299

Query: 281 WDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           WD+R   +    FE H+D    + W  PH+ + L S   D  L
Sbjct: 300 WDLRNLKLKLHTFESHKDEIFQVHW-SPHNETILASSGTDRRL 341


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 61/228 (26%), Positives = 98/228 (42%), Gaps = 37/228 (16%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H+  V +V FHP  + V++S S+D  +K +D    D   T  G ++SV+D+ F       
Sbjct: 107 HRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKL 164

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
            AS   +  ++LWD +  + C R    H+  V      P +   + +  RDK +K+W++ 
Sbjct: 165 LASCSADMTIKLWDFQGFE-CIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMWEVQ 222

Query: 239 THRAKEMHCVQTIASVARVKWRPECRHH-----LATCSMMVDHNIYVWDVRRPFVPAAMF 293
           T      +CV+T       +W    R +     +A+CS   D  + VW V      A + 
Sbjct: 223 TG-----YCVKTF--TGHREWVRMVRPNQDGTLIASCSN--DQTVRVWVVATKECKAEL- 272

Query: 294 EEHRDVTTGIAWRHPHDPS------------------FLLSGSKDSSL 323
            EH  V   I+W      S                  FLLSGS+D ++
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 55/227 (24%), Positives = 93/227 (40%), Gaps = 35/227 (15%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H   V+ V   P   H++ S S+D  +K ++++    V TF+G  E VR V+ + +D   
Sbjct: 191 HDHNVSSVAIMPNGDHIV-SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN-QDGTL 248

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDR------------------ 220
            AS   +  V++W +   + C+     H   V C  W PE                    
Sbjct: 249 IASCSNDQTVRVWVVATKE-CKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307

Query: 221 -GWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLA---TCSMMVDH 276
             +L +G RDK +K+WD++T       C+ T+  V    W      H       S   D 
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGM-----CLMTL--VGHDNWVRGVLFHSGGKFILSCADDK 360

Query: 277 NIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
            + VWD +       +   H    T + + H   P ++++GS D ++
Sbjct: 361 TLRVWDYKNKRCMKTL-NAHEHFVTSLDF-HKTAP-YVVTGSVDQTV 404



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 54/238 (22%), Positives = 98/238 (41%), Gaps = 35/238 (14%)

Query: 19  RTMHCHLDAPANAISVCRDAAQVVVAGRS-IFKIYAIEEEQFVEKLNLRVGRKPSLNLSC 77
           RTMH H D   +++++  +   +V A R    K++ ++    V+      G +  + +  
Sbjct: 186 RTMHGH-DHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFT---GHREWVRM-- 239

Query: 78  ADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAH--- 134
              V    D  L+A+ + +  V  W +       +     EH+  V  + + P  ++   
Sbjct: 240 ---VRPNQDGTLIASCSNDQTVRVWVVATKECKAE---LREHEHVVECISWAPESSYSSI 293

Query: 135 ----------------VLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
                            LLSGS+D  +K +D+     + T  G    VR V F     F 
Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFI 353

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWD 236
             S  ++  +++WD +   RC +   AH   V   D+H +   ++ TG  D+ VKVW+
Sbjct: 354 L-SCADDKTLRVWDYKNK-RCMKTLNAHEHFVTSLDFH-KTAPYVVTGSVDQTVKVWE 408


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/213 (26%), Positives = 94/213 (44%), Gaps = 23/213 (10%)

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLS-GSQDGF 144
           D+  +AT + +  V  WN       +    + EH   VN   F  +  H+LL+ GS D F
Sbjct: 668 DDRFIATCSVDKKVKIWN---SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 724

Query: 145 MKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDI-----RRPDRC 199
           +K +DL +K+  +T  G + SV   +FS  D    AS   +G ++LWD      R+    
Sbjct: 725 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINV 783

Query: 200 ERMFTAHNGP-------VFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIA 252
           ++ F     P       V CC W   D   +    ++K + +W+ T  R+K   C   ++
Sbjct: 784 KQFFLNLEDPQEDMEVIVKCCSW-SADGARIMVAAKNK-IFLWN-TDSRSKVADCRGHLS 840

Query: 253 SVARVKWRPECRHHLATCSMMVDHNIYVWDVRR 285
            V  V + P+    L +     D  I +W+ ++
Sbjct: 841 WVHGVMFSPDGSSFLTSSD---DQTIRLWETKK 870



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/211 (24%), Positives = 93/211 (44%), Gaps = 21/211 (9%)

Query: 34   VCRDAAQV------VVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLN---LSCADVVWHQ 84
            VC+++A +      VV   +   + A++  + ++ +N R G+   L    +SC  +  H 
Sbjct: 871  VCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHL 930

Query: 85   MDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGF 144
                 +A    NG +    L     N+  Q   +HK+TV  + F   E   L+S S D  
Sbjct: 931  Q---YIAFGDENGAIEILEL---VNNRIFQSRFQHKKTVWHIQFTADEK-TLISSSDDAE 983

Query: 145  MKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFT 204
            ++ ++ +  D      G  E+V+D  F +       S   +G V++W+I   ++ E+ F 
Sbjct: 984  IQVWNWQL-DKCIFLRGHQETVKD--FRLLKNSRLLSWSFDGTVKVWNIITGNK-EKDFV 1039

Query: 205  AHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
             H G V  CD   +   + +T   DK  K+W
Sbjct: 1040 CHQGTVLSCDISHDATKFSSTSA-DKTAKIW 1069



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 32/119 (26%), Positives = 47/119 (39%), Gaps = 6/119 (5%)

Query: 205 AHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECR 264
           AH   V CC +  +DR ++AT   DK VK+W+  T   + +H     +            
Sbjct: 655 AHEDEVLCCAFSTDDR-FIATCSVDKKVKIWNSMT--GELVHTYDEHSEQVNCCHFTNSS 711

Query: 265 HHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           HHL   +   D  + +WD+ +      MF     V      R   D   L S S D +L
Sbjct: 712 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN---HCRFSPDDKLLASCSADGTL 767



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 23/102 (22%), Positives = 45/102 (44%), Gaps = 9/102 (8%)

Query: 85   MDENLLATAATNGVVVTWNLGRPS-----RNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
            +D  LLAT   NG +  WN+             ++    H   V  +CF P    ++ +G
Sbjct: 1094 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153

Query: 140  SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFAS 181
               G++K +++   +S  TF     +++ +  S  D+ T+ +
Sbjct: 1154 ---GYIKWWNVVTGESSQTFYTNGTNLKKIHVS-PDFKTYVT 1191


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/213 (26%), Positives = 94/213 (44%), Gaps = 23/213 (10%)

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLS-GSQDGF 144
           D+  +AT + +  V  WN       +    + EH   VN   F  +  H+LL+ GS D F
Sbjct: 657 DDRFIATCSVDKKVKIWN---SMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCF 713

Query: 145 MKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDI-----RRPDRC 199
           +K +DL +K+  +T  G + SV   +FS  D    AS   +G ++LWD      R+    
Sbjct: 714 LKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINV 772

Query: 200 ERMFTAHNGP-------VFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIA 252
           ++ F     P       V CC W   D   +    ++K + +W+ T  R+K   C   ++
Sbjct: 773 KQFFLNLEDPQEDMEVIVKCCSW-SADGARIMVAAKNK-IFLWN-TDSRSKVADCRGHLS 829

Query: 253 SVARVKWRPECRHHLATCSMMVDHNIYVWDVRR 285
            V  V + P+    L +     D  I +W+ ++
Sbjct: 830 WVHGVMFSPDGSSFLTSSD---DQTIRLWETKK 859



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 52/211 (24%), Positives = 93/211 (44%), Gaps = 21/211 (9%)

Query: 34   VCRDAAQV------VVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLN---LSCADVVWHQ 84
            VC+++A +      VV   +   + A++  + ++ +N R G+   L    +SC  +  H 
Sbjct: 860  VCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHL 919

Query: 85   MDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGF 144
                 +A    NG +    L     N+  Q   +HK+TV  + F   E   L+S S D  
Sbjct: 920  Q---YIAFGDENGAIEILEL---VNNRIFQSRFQHKKTVWHIQFTADEK-TLISSSDDAE 972

Query: 145  MKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFT 204
            ++ ++ +  D      G  E+V+D  F +       S   +G V++W+I   ++ E+ F 
Sbjct: 973  IQVWNWQL-DKCIFLRGHQETVKD--FRLLKNSRLLSWSFDGTVKVWNIITGNK-EKDFV 1028

Query: 205  AHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
             H G V  CD   +   + +T   DK  K+W
Sbjct: 1029 CHQGTVLSCDISHDATKFSSTSA-DKTAKIW 1058



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 32/119 (26%), Positives = 47/119 (39%), Gaps = 6/119 (5%)

Query: 205 AHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECR 264
           AH   V CC +  +DR ++AT   DK VK+W+  T   + +H     +            
Sbjct: 644 AHEDEVLCCAFSTDDR-FIATCSVDKKVKIWNSMT--GELVHTYDEHSEQVNCCHFTNSS 700

Query: 265 HHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           HHL   +   D  + +WD+ +      MF     V      R   D   L S S D +L
Sbjct: 701 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVN---HCRFSPDDKLLASCSADGTL 756



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 23/102 (22%), Positives = 45/102 (44%), Gaps = 9/102 (8%)

Query: 85   MDENLLATAATNGVVVTWNLGRPS-----RNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
            +D  LLAT   NG +  WN+             ++    H   V  +CF P    ++ +G
Sbjct: 1083 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142

Query: 140  SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFAS 181
               G++K +++   +S  TF     +++ +  S  D+ T+ +
Sbjct: 1143 ---GYIKWWNVVTGESSQTFYTNGTNLKKIHVS-PDFKTYVT 1180


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 63/248 (25%), Positives = 110/248 (44%), Gaps = 27/248 (10%)

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVL-------LS 138
           +  +LATA  +G+   W++  P  N    L   H   V  + FHP     L        S
Sbjct: 242 NSKMLATACWSGLCKLWSV--PDCNLLHTL-RGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298

Query: 139 GSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDR 198
            + DG +K + L   + V+   G +  V  V +     F   + ++  + +LWD+   + 
Sbjct: 299 CAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR-SWRLWDLEAQEE 357

Query: 199 CERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVK 258
                  H+  V+   +H +D     TGG D   +VWD+ T R   M     +  +  + 
Sbjct: 358 ILHQ-EGHSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTGRC-IMFLEGHLKEIYGIN 414

Query: 259 WRPECRHHLATCSMMVDHNIYVWDVRRP----FVPAAMFEEHRDVTTGIAWRHPHDPSFL 314
           + P   +H+AT S   D+   VWD+R+      +PA     H+++ TG+ +   H  +FL
Sbjct: 415 FSPN-GYHIATGS--GDNTCKVWDLRQRRCVYTIPA-----HQNLVTGVKFEPIHG-NFL 465

Query: 315 LSGSKDSS 322
           L+G+ D++
Sbjct: 466 LTGAYDNT 473



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 39/160 (24%), Positives = 65/160 (40%), Gaps = 11/160 (6%)

Query: 78  ADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTE--HKRTVNKVCFHPTEAHV 135
           A V+WH      L T   +     W+L       Q+++  +  H   V  + FH  +  +
Sbjct: 327 ARVMWHPSGR-FLGTTCYDRSWRLWDL-----EAQEEILHQEGHSMGVYDIAFHQ-DGSL 379

Query: 136 LLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRR 195
             +G  D F + +DLR    +    G  + +  + FS   Y     + +N   ++WD+R+
Sbjct: 380 AGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDN-TCKVWDLRQ 438

Query: 196 PDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
             RC     AH   V    + P    +L TG  D   K+W
Sbjct: 439 R-RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 41/153 (26%), Positives = 70/153 (45%), Gaps = 9/153 (5%)

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D NL  + A +     W++   +     Q FT H+  +N +CF P     + +GS D   
Sbjct: 195 DFNLFISGACDASAKLWDVREGTCR---QTFTGHESDINAICFFP-NGEAICTGSDDASC 250

Query: 146 KCFDLRRKDSVSTFSGQSE--SVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMF 203
           + FDLR    +  FS +S    +  V FS+     FA  +++ N  +WD  + +R   + 
Sbjct: 251 RLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAG-YDDFNCNVWDSMKSERV-GIL 308

Query: 204 TAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWD 236
           + H+  V C     +    +ATG  D  +K+W+
Sbjct: 309 SGHDNRVSCLGVTADGMA-VATGSWDSFLKIWN 340


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 57/211 (27%), Positives = 96/211 (45%), Gaps = 23/211 (10%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H   V    F P + + LLS S+DG ++ + L+    +  + G +  V D QFS   Y+ 
Sbjct: 542 HSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY- 599

Query: 179 FASTFENGNVQLW--DIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWD 236
           F S   +   +LW  D  +P    R+F  H   V C  +HP +  ++ATG  D+ V++WD
Sbjct: 600 FVSGGHDRVARLWATDHYQP---LRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLWD 655

Query: 237 MTTHRAKEMHCVQTIAS----VARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAM 292
           +        +CV+        +  + + P  R  LAT +   D  + +WD+    +   +
Sbjct: 656 VLNG-----NCVRIFTGHKGPIHSLTFSPNGR-FLATGA--TDGRVLLWDIGHGLMVGEL 707

Query: 293 FEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
            + H D    +  R   D   L SGS D+++
Sbjct: 708 -KGHTDTVCSL--RFSRDGEILASGSMDNTV 735



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 36/123 (29%), Positives = 54/123 (43%), Gaps = 4/123 (3%)

Query: 114 QLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSI 173
           ++F  H   VN   FHP   +V  +GS D  ++ +D+   + V  F+G    +  + FS 
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVA-TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 679

Query: 174 RDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVK 233
              F  A+   +G V LWDI        +   H   V C      D   LA+G  D  V+
Sbjct: 680 NGRF-LATGATDGRVLLWDIGHGLMVGEL-KGHTDTV-CSLRFSRDGEILASGSMDNTVR 736

Query: 234 VWD 236
           +WD
Sbjct: 737 LWD 739


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 58/229 (25%), Positives = 94/229 (41%), Gaps = 24/229 (10%)

Query: 13  GSVLTGRTMHCHLDAPANAISVCR--DAAQVVVA-GRSIFKIYAIEEEQFVEKLNLRVGR 69
           G+V   R +  H       +S CR  D  Q+V + G +   ++ IE  Q         G 
Sbjct: 131 GNVRVSRELAGH----TGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGD 186

Query: 70  KPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFH 129
             SL+L+         D  L  + A +     W++         Q FT H+  +N +CF 
Sbjct: 187 VMSLSLA--------PDTRLFVSGACDASAKLWDV---REGMCRQTFTGHESDINAICFF 235

Query: 130 PTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE--SVRDVQFSIRDYFTFASTFENGN 187
           P   +   +GS D   + FDLR    + T+S  +    +  V FS       A  +++ N
Sbjct: 236 P-NGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG-YDDFN 293

Query: 188 VQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWD 236
             +WD  + DR   +   H+  V C     +D   +ATG  D  +K+W+
Sbjct: 294 CNVWDALKADRA-GVLAGHDNRVSCLG-VTDDGMAVATGSWDSFLKIWN 340


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 7/165 (4%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           +LLA+ + +  V  W    P+   +  +F  H  TV  V F  ++    ++ S D  +K 
Sbjct: 36  HLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFC-SDGQSFVTASDDKTVKV 91

Query: 148 FDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHN 207
           +   R+  + + S     VR  +FS  D     S  ++  V+LWD +    C   +  H 
Sbjct: 92  WATHRQKFLFSLSQHINWVRCAKFS-PDGRLIVSASDDKTVKLWD-KSSRECVHSYCEHG 149

Query: 208 GPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIA 252
           G V   D+HP     +A  G D  VKVWD+ THR  + + + + A
Sbjct: 150 GFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 193



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 16/210 (7%)

Query: 27  APANAISVCRDAAQVVVAGRS-IFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQM 85
           A   ++  C D    V A      K++A   ++F+  L+  +       + CA       
Sbjct: 66  ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW-----VRCAKF---SP 117

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D  L+ +A+ +  V  W+    S  +    + EH   V  V FHP+   +  +G  D  +
Sbjct: 118 DGRLIVSASDDKTVKLWD---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 173

Query: 146 KCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTA 205
           K +D+R    +  +   S +V  + F     +   ++ ++  +++ D+    R       
Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS-TLKILDLME-GRLLYTLHG 231

Query: 206 HNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
           H GP     +      + A+GG D+ V VW
Sbjct: 232 HQGPATTVAFSRTGE-YFASGGSDEQVMVW 260


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 7/165 (4%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           +LLA+ + +  V  W    P+   +  +F  H  TV  V F  ++    ++ S D  +K 
Sbjct: 74  HLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFC-SDGQSFVTASDDKTVKV 129

Query: 148 FDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHN 207
           +   R+  + + S     VR  +FS  D     S  ++  V+LWD +    C   +  H 
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFS-PDGRLIVSASDDKTVKLWD-KSSRECVHSYCEHG 187

Query: 208 GPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIA 252
           G V   D+HP     +A  G D  VKVWD+ THR  + + + + A
Sbjct: 188 GFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 231



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 62/252 (24%), Positives = 96/252 (38%), Gaps = 57/252 (22%)

Query: 116 FTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRD 175
           F  H+  V  V F       L SGS D  +  + ++ +     F+G  ++V  V FS   
Sbjct: 15  FKGHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73

Query: 176 YFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPV----FCCDWHPEDRGWLATGGRDKM 231
           +   AS   +  V++W +        +F AH   V    FC D          T   DK 
Sbjct: 74  HL-LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS-----FVTASDDKT 126

Query: 232 VKVWDMTTHRAKEMHCV-QTIASVARVKWRPECR-------------------------- 264
           VKVW   THR K +  + Q I  V   K+ P+ R                          
Sbjct: 127 VKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 265 -----------HHLATC--SMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDP 311
                      H   TC  +  +D+ + VWDVR   +    ++ H     G+++ HP   
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL-LQHYQLHSAAVNGLSF-HP-SG 241

Query: 312 SFLLSGSKDSSL 323
           ++L++ S DS+L
Sbjct: 242 NYLITASSDSTL 253



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 16/210 (7%)

Query: 27  APANAISVCRDAAQVVVAGRS-IFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQM 85
           A   ++  C D    V A      K++A   ++F+  L+  +       + CA       
Sbjct: 104 ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW-----VRCAKF---SP 155

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D  L+ +A+ +  V  W+    S  +    + EH   V  V FHP+   +  +G  D  +
Sbjct: 156 DGRLIVSASDDKTVKLWD---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 211

Query: 146 KCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTA 205
           K +D+R    +  +   S +V  + F     +   ++ ++  +++ D+    R       
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS-TLKILDLME-GRLLYTLHG 269

Query: 206 HNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
           H GP     +      + A+GG D+ V VW
Sbjct: 270 HQGPATTVAFSRTGE-YFASGGSDEQVMVW 298


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 7/165 (4%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           +LLA+ + +  V  W    P+   +  +F  H  TV  V F  ++    ++ S D  +K 
Sbjct: 74  HLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFC-SDGQSFVTASDDKTVKV 129

Query: 148 FDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHN 207
           +   R+  + + S     VR  +FS  D     S  ++  V+LWD +    C   +  H 
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFS-PDGRLIVSASDDKTVKLWD-KSSRECVHSYCEHG 187

Query: 208 GPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIA 252
           G V   D+HP     +A  G D  VKVWD+ THR  + + + + A
Sbjct: 188 GFVTYVDFHPSGT-CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 231



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 62/252 (24%), Positives = 96/252 (38%), Gaps = 57/252 (22%)

Query: 116 FTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRD 175
           F  H+  V  V F       L SGS D  +  + ++ +     F+G  ++V  V FS   
Sbjct: 15  FKGHRDAVTCVDFS-INTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73

Query: 176 YFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPV----FCCDWHPEDRGWLATGGRDKM 231
           +   AS   +  V++W +        +F AH   V    FC D          T   DK 
Sbjct: 74  HL-LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQS-----FVTASDDKT 126

Query: 232 VKVWDMTTHRAKEMHCV-QTIASVARVKWRPECR-------------------------- 264
           VKVW   THR K +  + Q I  V   K+ P+ R                          
Sbjct: 127 VKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 184

Query: 265 -----------HHLATC--SMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDP 311
                      H   TC  +  +D+ + VWDVR   +    ++ H     G+++ HP   
Sbjct: 185 EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRL-LQHYQLHSAAVNGLSF-HP-SG 241

Query: 312 SFLLSGSKDSSL 323
           ++L++ S DS+L
Sbjct: 242 NYLITASSDSTL 253



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 16/210 (7%)

Query: 27  APANAISVCRDAAQVVVAGRS-IFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQM 85
           A   ++  C D    V A      K++A   ++F+  L+  +       + CA       
Sbjct: 104 ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINW-----VRCAKF---SP 155

Query: 86  DENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFM 145
           D  L+ +A+ +  V  W+    S  +    + EH   V  V FHP+   +  +G  D  +
Sbjct: 156 DGRLIVSASDDKTVKLWD---KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG-MDNTV 211

Query: 146 KCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTA 205
           K +D+R    +  +   S +V  + F     +   ++ ++  +++ D+    R       
Sbjct: 212 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS-TLKILDLME-GRLLYTLHG 269

Query: 206 HNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
           H GP     +      + A+GG D+ V VW
Sbjct: 270 HQGPATTVAFSRTGE-YFASGGSDEQVMVW 298


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 53/242 (21%), Positives = 93/242 (38%), Gaps = 29/242 (11%)

Query: 63  LNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGR-PSRNK---QDQLFTE 118
           L LR  +K    LS     W+      L +A+ +  +  W++   P   K      +FT 
Sbjct: 136 LRLRGHQKEGYGLS-----WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 190

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVS---TFSGQSESVRDVQFSIRD 175
           H   V  V +H     +  S + D  +  +D R  ++     +    +  V  + F+   
Sbjct: 191 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250

Query: 176 YFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
            F  A+   +  V LWD+R        F +H   +F   W P +   LA+ G D+ + VW
Sbjct: 251 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 310

Query: 236 DMTTHRAKE--------------MHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVW 281
           D++    ++              +H   T A ++   W P        CS+  D+ + VW
Sbjct: 311 DLSKIGEEQSPEDAEDGPPELLFIHGGHT-AKISDFSWNP--NEPWVICSVSEDNIMQVW 367

Query: 282 DV 283
            +
Sbjct: 368 QM 369



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/237 (21%), Positives = 92/237 (38%), Gaps = 21/237 (8%)

Query: 105 GRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE 164
           G  S   + ++   H+  VN+  + P    ++ + +    +  FD  +  S    SG+  
Sbjct: 74  GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 133

Query: 165 SVRDVQFSIRDYFTFA----------STFENGNVQLWDIRRPDR------CERMFTAHNG 208
               ++   ++ +  +          S  ++  + LWDI    +       + +FT H  
Sbjct: 134 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 193

Query: 209 PVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHR-AKEMHCVQT-IASVARVKWRPECRHH 266
            V    WH        +   D+ + +WD  ++  +K  H V    A V  + + P     
Sbjct: 194 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 253

Query: 267 LATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           LAT S   D  + +WD+R   +    FE H+D    + W  PH+ + L S   D  L
Sbjct: 254 LATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQW-SPHNETILASSGTDRRL 307


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 53/242 (21%), Positives = 93/242 (38%), Gaps = 29/242 (11%)

Query: 63  LNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGR-PSRNK---QDQLFTE 118
           L LR  +K    LS     W+      L +A+ +  +  W++   P   K      +FT 
Sbjct: 170 LRLRGHQKEGYGLS-----WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 224

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVS---TFSGQSESVRDVQFSIRD 175
           H   V  V +H     +  S + D  +  +D R  ++     +    +  V  + F+   
Sbjct: 225 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 284

Query: 176 YFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
            F  A+   +  V LWD+R        F +H   +F   W P +   LA+ G D+ + VW
Sbjct: 285 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 344

Query: 236 DMTTHRAKE--------------MHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVW 281
           D++    ++              +H   T A ++   W P        CS+  D+ + VW
Sbjct: 345 DLSKIGEEQSPEDAEDGPPELLFIHGGHT-AKISDFSWNP--NEPWVICSVSEDNIMQVW 401

Query: 282 DV 283
            +
Sbjct: 402 QM 403



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/237 (21%), Positives = 92/237 (38%), Gaps = 21/237 (8%)

Query: 105 GRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE 164
           G  S   + ++   H+  VN+  + P    ++ + +    +  FD  +  S    SG+  
Sbjct: 108 GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 167

Query: 165 SVRDVQFSIRDYFTFA----------STFENGNVQLWDIRRPDR------CERMFTAHNG 208
               ++   ++ +  +          S  ++  + LWDI    +       + +FT H  
Sbjct: 168 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 227

Query: 209 PVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHR-AKEMHCVQT-IASVARVKWRPECRHH 266
            V    WH        +   D+ + +WD  ++  +K  H V    A V  + + P     
Sbjct: 228 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 287

Query: 267 LATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           LAT S   D  + +WD+R   +    FE H+D    + W  PH+ + L S   D  L
Sbjct: 288 LATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQW-SPHNETILASSGTDRRL 341


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 53/242 (21%), Positives = 93/242 (38%), Gaps = 29/242 (11%)

Query: 63  LNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGR-PSRNK---QDQLFTE 118
           L LR  +K    LS     W+      L +A+ +  +  W++   P   K      +FT 
Sbjct: 171 LRLRGHQKEGYGLS-----WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 225

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVS---TFSGQSESVRDVQFSIRD 175
           H   V  V +H     +  S + D  +  +D R  ++     +    +  V  + F+   
Sbjct: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285

Query: 176 YFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVW 235
            F  A+   +  V LWD+R        F +H   +F   W P +   LA+ G D+ + VW
Sbjct: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345

Query: 236 DMTTHRAKE--------------MHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVW 281
           D++    ++              +H   T A ++   W P        CS+  D+ + VW
Sbjct: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHT-AKISDFSWNP--NEPWVICSVSEDNIMQVW 402

Query: 282 DV 283
            +
Sbjct: 403 QM 404



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 50/237 (21%), Positives = 92/237 (38%), Gaps = 21/237 (8%)

Query: 105 GRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE 164
           G  S   + ++   H+  VN+  + P    ++ + +    +  FD  +  S    SG+  
Sbjct: 109 GSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 168

Query: 165 SVRDVQFSIRDYFTFA----------STFENGNVQLWDIRRPDR------CERMFTAHNG 208
               ++   ++ +  +          S  ++  + LWDI    +       + +FT H  
Sbjct: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228

Query: 209 PVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHR-AKEMHCVQT-IASVARVKWRPECRHH 266
            V    WH        +   D+ + +WD  ++  +K  H V    A V  + + P     
Sbjct: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288

Query: 267 LATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           LAT S   D  + +WD+R   +    FE H+D    + W  PH+ + L S   D  L
Sbjct: 289 LATGS--ADKTVALWDLRNLKLKLHSFESHKDEIFQVQW-SPHNETILASSGTDRRL 342


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 36/157 (22%), Positives = 73/157 (46%), Gaps = 2/157 (1%)

Query: 82  WHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQ 141
           W Q +++++AT   +  V  + +   S ++  ++F+ H   V  V + P    +L SGS 
Sbjct: 505 WSQNNKDMIATGCEDTNVRVYYVATSS-DQPLKVFSGHTAKVFHVKWSPLREGILCSGSD 563

Query: 142 DGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCER 201
           DG ++ +D  +   ++  +G +  VR + ++    +   S   +  +++WD R    C  
Sbjct: 564 DGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE-GTCVD 622

Query: 202 MFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
               H   V+    HP     +A+  RD  V++W +T
Sbjct: 623 TVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLT 659



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 68/280 (24%), Positives = 109/280 (38%), Gaps = 49/280 (17%)

Query: 86  DENLLATAATNGVVVTWNL------------------------------GRPSRN----- 110
           D NLLATA+ +G +  W++                              G  SRN     
Sbjct: 381 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 440

Query: 111 -----KQDQLFTEH-KRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE 164
                K  Q F EH    +  + +   ++  + + S DGF  C        V        
Sbjct: 441 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF--CIIRTIDGKVLHKYKHPA 498

Query: 165 SVRDVQFSIRDYFTFASTFENGNVQLWDI-RRPDRCERMFTAHNGPVFCCDWHPEDRGWL 223
           +V    +S  +    A+  E+ NV+++ +    D+  ++F+ H   VF   W P   G L
Sbjct: 499 AVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGIL 558

Query: 224 ATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDV 283
            +G  D  V++WD T      +    T A V  + W  E  + L + S   D+ I VWD 
Sbjct: 559 CSGSDDGTVRIWDYTQDACINILNGHT-APVRGLMWNTEIPYLLISGSW--DYTIKVWDT 615

Query: 284 RRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           R       +++   DV  G+   HP  P  + S S+DS++
Sbjct: 616 REGTCVDTVYDHGADV-YGLTC-HPSRPFTMASCSRDSTV 653



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 46/207 (22%), Positives = 80/207 (38%), Gaps = 9/207 (4%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H  T+    F P + ++L + S DG +K +D+    +V T  G    +  + ++      
Sbjct: 368 HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNC 427

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
            A         +W++++    +R        +FC  W  +D   +AT   D    +    
Sbjct: 428 IAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCII---R 484

Query: 239 THRAKEMHCVQTIASVARVKWRPECRHHLAT-CSMMVDHNIYVWDVRRPF-VPAAMFEEH 296
           T   K +H  +  A+V    W    +  +AT C    D N+ V+ V      P  +F  H
Sbjct: 485 TIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCE---DTNVRVYYVATSSDQPLKVFSGH 541

Query: 297 RDVTTGIAWRHPHDPSFLLSGSKDSSL 323
                 + W  P     L SGS D ++
Sbjct: 542 TAKVFHVKW-SPLREGILCSGSDDGTV 567



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 80  VVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
           V W  + E +L + + +G V  W+    +++    +   H   V  + ++    ++L+SG
Sbjct: 548 VKWSPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISG 604

Query: 140 SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDI 193
           S D  +K +D R    V T       V  +       FT AS   +  V+LW +
Sbjct: 605 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 23/130 (17%), Positives = 48/130 (36%), Gaps = 7/130 (5%)

Query: 111 KQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQ 170
           K   + +EHK+T+  + + P    +  SGS D  +  +++  +  ++           + 
Sbjct: 50  KLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLS 109

Query: 171 FSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCD-----WHPEDRGWLAT 225
           +        A     G + +W I  PD    +    +   F  D     WH   +G +  
Sbjct: 110 WCWNAEDVVAFVSHRGPLFIWTISGPD--SGVIVHKDAHSFLSDICMFRWHTHQKGKVVF 167

Query: 226 GGRDKMVKVW 235
           G  D  + ++
Sbjct: 168 GHIDGSLSIF 177



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 2/45 (4%)

Query: 278 IYVWDVR-RPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDS 321
           IY  D R   F   A+  EH+   T I+W  PH+P    SGS D+
Sbjct: 39  IYQLDHRYNEFKLHAIMSEHKKTITAISWC-PHNPDLFASGSTDN 82


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 36/157 (22%), Positives = 73/157 (46%), Gaps = 2/157 (1%)

Query: 82  WHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQ 141
           W Q +++++AT   +  V  + +   S ++  ++F+ H   V  V + P    +L SGS 
Sbjct: 529 WSQNNKDMIATGCEDTNVRVYYVATSS-DQPLKVFSGHTAKVFHVKWSPLREGILCSGSD 587

Query: 142 DGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCER 201
           DG ++ +D  +   ++  +G +  VR + ++    +   S   +  +++WD R    C  
Sbjct: 588 DGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRE-GTCVD 646

Query: 202 MFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
               H   V+    HP     +A+  RD  V++W +T
Sbjct: 647 TVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSLT 683



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 68/280 (24%), Positives = 109/280 (38%), Gaps = 49/280 (17%)

Query: 86  DENLLATAATNGVVVTWNL------------------------------GRPSRN----- 110
           D NLLATA+ +G +  W++                              G  SRN     
Sbjct: 405 DPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAFIW 464

Query: 111 -----KQDQLFTEH-KRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE 164
                K  Q F EH    +  + +   ++  + + S DGF  C        V        
Sbjct: 465 NVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF--CIIRTIDGKVLHKYKHPA 522

Query: 165 SVRDVQFSIRDYFTFASTFENGNVQLWDI-RRPDRCERMFTAHNGPVFCCDWHPEDRGWL 223
           +V    +S  +    A+  E+ NV+++ +    D+  ++F+ H   VF   W P   G L
Sbjct: 523 AVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGIL 582

Query: 224 ATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDV 283
            +G  D  V++WD T      +    T A V  + W  E  + L + S   D+ I VWD 
Sbjct: 583 CSGSDDGTVRIWDYTQDACINILNGHT-APVRGLMWNTEIPYLLISGSW--DYTIKVWDT 639

Query: 284 RRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSSL 323
           R       +++   DV  G+   HP  P  + S S+DS++
Sbjct: 640 REGTCVDTVYDHGADV-YGLTC-HPSRPFTMASCSRDSTV 677



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 46/207 (22%), Positives = 80/207 (38%), Gaps = 9/207 (4%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H  T+    F P + ++L + S DG +K +D+    +V T  G    +  + ++      
Sbjct: 392 HVETIFDCKFKPDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNC 451

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
            A         +W++++    +R        +FC  W  +D   +AT   D    +    
Sbjct: 452 IAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCII---R 508

Query: 239 THRAKEMHCVQTIASVARVKWRPECRHHLAT-CSMMVDHNIYVWDVRRPF-VPAAMFEEH 296
           T   K +H  +  A+V    W    +  +AT C    D N+ V+ V      P  +F  H
Sbjct: 509 TIDGKVLHKYKHPAAVFGCDWSQNNKDMIATGCE---DTNVRVYYVATSSDQPLKVFSGH 565

Query: 297 RDVTTGIAWRHPHDPSFLLSGSKDSSL 323
                 + W  P     L SGS D ++
Sbjct: 566 TAKVFHVKW-SPLREGILCSGSDDGTV 591



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/114 (23%), Positives = 49/114 (42%), Gaps = 3/114 (2%)

Query: 80  VVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
           V W  + E +L + + +G V  W+    +++    +   H   V  + ++    ++L+SG
Sbjct: 572 VKWSPLREGILCSGSDDGTVRIWDY---TQDACINILNGHTAPVRGLMWNTEIPYLLISG 628

Query: 140 SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDI 193
           S D  +K +D R    V T       V  +       FT AS   +  V+LW +
Sbjct: 629 SWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 682



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 23/130 (17%), Positives = 48/130 (36%), Gaps = 7/130 (5%)

Query: 111 KQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQ 170
           K   + +EHK+T+  + + P    +  SGS D  +  +++  +  ++           + 
Sbjct: 74  KLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLS 133

Query: 171 FSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCD-----WHPEDRGWLAT 225
           +        A     G + +W I  PD    +    +   F  D     WH   +G +  
Sbjct: 134 WCWNAEDVVAFVSHRGPLFIWTISGPD--SGVIVHKDAHSFLSDICMFRWHTHQKGKVVF 191

Query: 226 GGRDKMVKVW 235
           G  D  + ++
Sbjct: 192 GHIDGSLSIF 201



 Score = 30.4 bits (67), Expect = 6.7
 Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 2/45 (4%)

Query: 278 IYVWDVR-RPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDS 321
           IY  D R   F   A+  EH+   T I+W  PH+P    SGS D+
Sbjct: 63  IYQLDHRYNEFKLHAIMSEHKKTITAISWC-PHNPDLFASGSTDN 106


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 53/215 (24%), Positives = 95/215 (44%), Gaps = 21/215 (9%)

Query: 79  DVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLS 138
           DV W     N  A+ +T+  +    LG+   ++  + F  H   VN + + PT  ++L S
Sbjct: 313 DVDWQS--NNTFASCSTDMCIHVCKLGQ---DRPIKTFQGHTNEVNAIKWDPT-GNLLAS 366

Query: 139 GSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT--------FASTFENGNVQL 190
            S D  +K + +++ + V      ++ +  +++S     T         AS   +  V+L
Sbjct: 367 CSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRL 426

Query: 191 WDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQT 250
           WD+ R   C    T H  PV+   + P+ R +LA+G  DK V +W+  T     +H  + 
Sbjct: 427 WDVDR-GICIHTLTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWN--TQTGALVHSYRG 482

Query: 251 IASVARVKWRPECRHHLATCSMMVDHNIYVWDVRR 285
              +  V W        A+ S   D ++ V D+R+
Sbjct: 483 TGGIFEVCWNAAGDKVGASAS---DGSVCVLDLRK 514



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 56/280 (20%), Positives = 112/280 (40%), Gaps = 37/280 (13%)

Query: 82  WHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEH-----------KRTVNKVCFHP 130
           W+ + + LLA+ + +     WNL   S +   QL   H            + V  + ++ 
Sbjct: 177 WNPVSD-LLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWN- 234

Query: 131 TEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQL 190
           +E  +L +GS DGF + +  +  +  ST       +  ++++ +  F  ++  +   + +
Sbjct: 235 SEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTI-I 292

Query: 191 WDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQT 250
           WD    +  ++ F  H+ P    DW  +     A+   D  + V  +   R  +     T
Sbjct: 293 WDAHTGE-AKQQFPFHSAPALDVDW--QSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHT 349

Query: 251 IASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDV------TTGIA 304
              V  +KW P   + LA+CS   D  + +W +++      +   ++++       TG  
Sbjct: 350 -NEVNAIKWDP-TGNLLASCS--DDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405

Query: 305 WRHPHDPSFLLSGSKDSS---------LCQHLFRDASQPV 335
             +P+    L S S DS+         +C H      +PV
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPV 445



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 43/209 (20%), Positives = 83/209 (39%), Gaps = 27/209 (12%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           N + +A  +   + W+       +Q   F  H      V +     +   S S D  +  
Sbjct: 279 NFILSAGVDKTTIIWDAHTGEAKQQ---FPFHSAPALDVDWQSN--NTFASCSTDMCIHV 333

Query: 148 FDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHN 207
             L +   + TF G +  V  +++        AS  ++  +++W +++ D C     AHN
Sbjct: 334 CKLGQDRPIKTFQGHTNEVNAIKWDPTGNL-LASCSDDMTLKIWSMKQ-DNCVHDLQAHN 391

Query: 208 GPVFCCDWHPEDRG--------WLATGGRDKMVKVWDMTTHRAKEMHCVQTIAS----VA 255
             ++   W P   G         LA+   D  V++WD+         C+ T+      V 
Sbjct: 392 KEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV-----DRGICIHTLTKHQEPVY 446

Query: 256 RVKWRPECRHHLATCSMMVDHNIYVWDVR 284
            V + P+ R +LA+ S   D  +++W+ +
Sbjct: 447 SVAFSPDGR-YLASGSF--DKCVHIWNTQ 472



 Score = 30.8 bits (68), Expect = 5.1
 Identities = 13/47 (27%), Positives = 22/47 (46%), Gaps = 1/47 (2%)

Query: 192 DIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
           D+  P     +   H   VF C W+P     LA+G  D   ++W+++
Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLS 199


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 81  VWH-QMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
           VW  QM +N++ + +T+  +  WN         + + T +  T    C H  E  V+ SG
Sbjct: 306 VWSSQMRDNIIISGSTDRTLKVWNA-----ETGECIHTLYGHTSTVRCMHLHEKRVV-SG 359

Query: 140 SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRC 199
           S+D  ++ +D+     +    G   +VR VQ+  R   + A  F    V++WD    + C
Sbjct: 360 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF---MVKVWD-PETETC 415

Query: 200 ERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKW 259
                 H   V+   +   D   + +G  D  ++VWD+ T      +C+ T+     +  
Sbjct: 416 LHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVWDVETG-----NCIHTLTGHQSLTS 467

Query: 260 RPECRHHLATCSMMVDHNIYVWDVR 284
             E + ++   S   D  + +WD++
Sbjct: 468 GMELKDNILV-SGNADSTVKIWDIK 491


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 81  VWH-QMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
           VW  QM +N++ + +T+  +  WN         + + T +  T    C H  E  V+ SG
Sbjct: 424 VWSSQMRDNIIISGSTDRTLKVWNA-----ETGECIHTLYGHTSTVRCMHLHEKRVV-SG 477

Query: 140 SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRC 199
           S+D  ++ +D+     +    G   +VR VQ+  R   + A  F    V++WD    + C
Sbjct: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF---MVKVWD-PETETC 533

Query: 200 ERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKW 259
                 H   V+   +   D   + +G  D  ++VWD+ T      +C+ T+     +  
Sbjct: 534 LHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVWDVETG-----NCIHTLTGHQSLTS 585

Query: 260 RPECRHHLATCSMMVDHNIYVWDVR 284
             E + ++   S   D  + +WD++
Sbjct: 586 GMELKDNILV-SGNADSTVKIWDIK 609


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)

Query: 81  VWH-QMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSG 139
           VW  QM +N++ + +T+  +  WN         + + T +  T    C H  E  V+ SG
Sbjct: 344 VWSSQMRDNIIISGSTDRTLKVWNA-----ETGECIHTLYGHTSTVRCMHLHEKRVV-SG 397

Query: 140 SQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRC 199
           S+D  ++ +D+     +    G   +VR VQ+  R   + A  F    V++WD    + C
Sbjct: 398 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF---MVKVWD-PETETC 453

Query: 200 ERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKW 259
                 H   V+   +   D   + +G  D  ++VWD+ T      +C+ T+     +  
Sbjct: 454 LHTLQGHTNRVYSLQF---DGIHVVSGSLDTSIRVWDVETG-----NCIHTLTGHQSLTS 505

Query: 260 RPECRHHLATCSMMVDHNIYVWDVR 284
             E + ++   S   D  + +WD++
Sbjct: 506 GMELKDNILV-SGNADSTVKIWDIK 529


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 35/133 (26%), Positives = 64/133 (48%), Gaps = 9/133 (6%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H + V+ V F P     L S S D  +K +         T SG    + DV +S  D   
Sbjct: 44  HTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
             S  ++  +++WD+    +C +    H+  VFCC+++P+    + +G  D+ V++WD+ 
Sbjct: 102 LVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVK 159

Query: 239 THRAKEMHCVQTI 251
           T +     C++T+
Sbjct: 160 TGK-----CLKTL 167



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 45/200 (22%), Positives = 89/200 (44%), Gaps = 17/200 (8%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           NL+ + + +  V  W++      K  +    H   V+ V F+  +  +++S S DG  + 
Sbjct: 142 NLIVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRI 197

Query: 148 FDLRRKDSVSTF-SGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAH 206
           +D      + T     +  V  V+FS    +  A+T +N  ++LWD  +  +C + +T H
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN-TLKLWDYSK-GKCLKTYTGH 255

Query: 207 NGPVFC--CDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPEC- 263
               +C   ++      W+ +G  D +V +W++ T   KE+  VQ +     V     C 
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT---KEI--VQKLQGHTDVVISTACH 310

Query: 264 --RHHLATCSMMVDHNIYVW 281
              + +A+ ++  D  I +W
Sbjct: 311 PTENIIASAALENDKTIKLW 330


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 35/133 (26%), Positives = 64/133 (48%), Gaps = 9/133 (6%)

Query: 119 HKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFT 178
           H + V+ V F P     L S S D  +K +         T SG    + DV +S  D   
Sbjct: 44  HTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNL 101

Query: 179 FASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMT 238
             S  ++  +++WD+    +C +    H+  VFCC+++P+    + +G  D+ V++WD+ 
Sbjct: 102 LVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVK 159

Query: 239 THRAKEMHCVQTI 251
           T +     C++T+
Sbjct: 160 TGK-----CLKTL 167



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 45/200 (22%), Positives = 89/200 (44%), Gaps = 17/200 (8%)

Query: 88  NLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKC 147
           NL+ + + +  V  W++      K  +    H   V+ V F+  +  +++S S DG  + 
Sbjct: 142 NLIVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRI 197

Query: 148 FDLRRKDSVSTF-SGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAH 206
           +D      + T     +  V  V+FS    +  A+T +N  ++LWD  +  +C + +T H
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN-TLKLWDYSK-GKCLKTYTGH 255

Query: 207 NGPVFC--CDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPEC- 263
               +C   ++      W+ +G  D +V +W++ T   KE+  VQ +     V     C 
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT---KEI--VQKLQGHTDVVISTACH 310

Query: 264 --RHHLATCSMMVDHNIYVW 281
              + +A+ ++  D  I +W
Sbjct: 311 PTENIIASAALENDKTIKLW 330


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,824,892
Number of Sequences: 37866
Number of extensions: 1560872
Number of successful extensions: 5097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 4172
Number of HSP's gapped (non-prelim): 772
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.