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Search of human proteins with 14149607
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149607 chloride channel 7 isoform a [Homo sapiens]
(805 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 1597 0.0
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 1536 0.0
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 528 e-150
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 288 1e-77
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 261 2e-69
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 261 2e-69
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 261 2e-69
gi|153252026 chloride channel 4 [Homo sapiens] 253 4e-67
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 253 6e-67
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 248 1e-65
gi|156104869 chloride channel 2 [Homo sapiens] 191 2e-48
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 183 6e-46
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 179 1e-44
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 179 1e-44
gi|155969705 chloride channel Kb [Homo sapiens] 167 5e-41
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 147 4e-35
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 146 7e-35
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 32 2.3
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 32 2.3
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 32 2.3
gi|18702331 OTU domain containing 7A [Homo sapiens] 32 2.3
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 32 2.3
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens] 31 4.0
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 1597 bits (4134), Expect = 0.0
Identities = 805/805 (100%), Positives = 805/805 (100%)
Query: 1 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60
MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
Sbjct: 1 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60
Query: 61 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120
SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
Sbjct: 61 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120
Query: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180
TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
Sbjct: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180
Query: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240
TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
Sbjct: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240
Query: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
Sbjct: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300
Query: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360
FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
Sbjct: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360
Query: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420
GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
Sbjct: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420
Query: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480
AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
Sbjct: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480
Query: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540
PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
Sbjct: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540
Query: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600
WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
Sbjct: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600
Query: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660
LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
Sbjct: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660
Query: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720
FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
Sbjct: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720
Query: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780
IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
Sbjct: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780
Query: 781 LVTRKDLARYRLGKRGLEELSLAQT 805
LVTRKDLARYRLGKRGLEELSLAQT
Sbjct: 781 LVTRKDLARYRLGKRGLEELSLAQT 805
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 1536 bits (3978), Expect = 0.0
Identities = 781/805 (97%), Positives = 781/805 (97%), Gaps = 24/805 (2%)
Query: 1 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60
MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ
Sbjct: 1 MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ------------- 47
Query: 61 SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120
DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
Sbjct: 48 -----------DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 96
Query: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180
TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
Sbjct: 97 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 156
Query: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240
TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
Sbjct: 157 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 216
Query: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
Sbjct: 217 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 276
Query: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360
FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
Sbjct: 277 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 336
Query: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420
GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
Sbjct: 337 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 396
Query: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480
AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
Sbjct: 397 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 456
Query: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540
PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
Sbjct: 457 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 516
Query: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600
WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
Sbjct: 517 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 576
Query: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660
LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
Sbjct: 577 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 636
Query: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720
FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
Sbjct: 637 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 696
Query: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780
IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
Sbjct: 697 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 756
Query: 781 LVTRKDLARYRLGKRGLEELSLAQT 805
LVTRKDLARYRLGKRGLEELSLAQT
Sbjct: 757 LVTRKDLARYRLGKRGLEELSLAQT 781
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 528 bits (1360), Expect = e-150
Identities = 313/724 (43%), Positives = 446/724 (61%), Gaps = 48/724 (6%)
Query: 94 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
Query: 334 STFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMA--YTIHEIPVFIAMGVVGGV 387
+TFTLNF S I G+ PGL+NFG F DS+K +T ++ F+ MGV+GG+
Sbjct: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346
Query: 388 LGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL---- 441
LGA FN LN L +R+R +H +P L +V+E++LV+ VT V FV +C+ +
Sbjct: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSS 406
Query: 442 QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL 490
Q G+ S+ LQ+ FC + YN MA FFN E +++ LFH G+++P+TL
Sbjct: 407 QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTL 465
Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF-GISLSYLTGAAIWADPGKYAL 549
LF ++YF LACWTYG++V +G+F+PSLL GAA+GRL + SY+ I++ G +AL
Sbjct: 466 ALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFAL 523
Query: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQ 609
+GAAA LGG+VRMT+SLTVI++E+T+ +TYG PIM+ LM AK GD F +G+YD+H+ L+
Sbjct: 524 IGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLR 583
Query: 610 SVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADD 669
VP L WE V L A ++M +T + ++ +V +L T H+ FPVV
Sbjct: 584 GVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRG 641
Query: 670 TQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVS 727
+ ++G L S I K + ++R R + + +YP + H++
Sbjct: 642 NEKEFMKGNQLISNNIKFKKSSILTRAG-----EQRKRSQSMK-SYPSSELRNMCDEHIA 695
Query: 728 QDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVG 780
+E DL + M P P P ++ + + FR L L++ R+Q+V
Sbjct: 696 SEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVT 752
Query: 781 LVTR 784
L+ R
Sbjct: 753 LLVR 756
Score = 90.9 bits (224), Expect = 4e-18
Identities = 46/117 (39%), Positives = 68/117 (58%)
Query: 671 QPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDE 730
+P GLILRSQL+ LL V S Q RL + + YPR+P I + ++
Sbjct: 737 RPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLN 796
Query: 731 RECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
+D++ +MNPSP+TV + +VF LFR +GLRHL VV+ ++VG++TR +L
Sbjct: 797 PRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 288 bits (737), Expect = 1e-77
Identities = 149/273 (54%), Positives = 193/273 (70%), Gaps = 2/273 (0%)
Query: 94 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286
Query: 334 STFTLNFVLS-IYHGNMWDLSSPGLINFGRFDS 365
+TFTLNF S I G+ PGL+NFG F S
Sbjct: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKS 319
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 261 bits (667), Expect = 2e-69
Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
W++ LIG+L+G +A IDI + LK + G DK
Sbjct: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
T++G + F +LWA L F + +V P A GSGIP+IK
Sbjct: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
L+G I + TLVIK ++L+V GL++GKEGP++H G+++ +
Sbjct: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR
Sbjct: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
FFA++++ FTL + + + ++ + F + + + E+ FI +G+ GG
Sbjct: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
+ GA+F N W + + + VIE ++V A+TA +AF Y+ L
Sbjct: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
+LF G +S FNT + + G Y+ + L L ++ +
Sbjct: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
+T+G+ + +G+FIPS+ +GA GRL G+ + S+ + A PG
Sbjct: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
YA++GAAA LGG+ RMT+SL VIM E T + Y P+M MT+K V D EG+YD H
Sbjct: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
I+L PFL + +H A +VM + P+ + ++ + V + ++S+T ++
Sbjct: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
GFPVV + RL G +LR LI+ +++ + G+V + F + P P
Sbjct: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
P T+ L ++ SP+TV + V +FR LGLR +V N +++
Sbjct: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
Query: 780 GLVTRKDLARY 790
G++T+KD+ ++
Sbjct: 791 GIITKKDVLKH 801
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 261 bits (667), Expect = 2e-69
Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
W++ LIG+L+G +A IDI + LK + G DK
Sbjct: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187
Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
T++G + F +LWA L F + +V P A GSGIP+IK
Sbjct: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244
Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
L+G I + TLVIK ++L+V GL++GKEGP++H G+++ +
Sbjct: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300
Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR
Sbjct: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350
Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
FFA++++ FTL + + + ++ + F + + + E+ FI +G+ GG
Sbjct: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400
Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
+ GA+F N W + + + VIE ++V A+TA +AF Y+ L
Sbjct: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456
Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
+LF G +S FNT + + G Y+ + L L ++ +
Sbjct: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511
Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
+T+G+ + +G+FIPS+ +GA GRL G+ + S+ + A PG
Sbjct: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571
Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
YA++GAAA LGG+ RMT+SL VIM E T + Y P+M MT+K V D EG+YD H
Sbjct: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631
Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
I+L PFL + +H A +VM + P+ + ++ + V + ++S+T ++
Sbjct: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688
Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
GFPVV + RL G +LR LI+ +++ + G+V + F + P P
Sbjct: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740
Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
P T+ L ++ SP+TV + V +FR LGLR +V N +++
Sbjct: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790
Query: 780 GLVTRKDLARY 790
G++T+KD+ ++
Sbjct: 791 GIITKKDVLKH 801
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 261 bits (667), Expect = 2e-69
Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
W++ LIG+L+G +A IDI + LK + G DK
Sbjct: 58 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 117
Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
T++G + F +LWA L F + +V P A GSGIP+IK
Sbjct: 118 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 174
Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
L+G I + TLVIK ++L+V GL++GKEGP++H G+++ +
Sbjct: 175 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 230
Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR
Sbjct: 231 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 280
Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
FFA++++ FTL + + + ++ + F + + + E+ FI +G+ GG
Sbjct: 281 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 330
Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
+ GA+F N W + + + VIE ++V A+TA +AF Y+ L
Sbjct: 331 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 386
Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
+LF G +S FNT + + G Y+ + L L ++ +
Sbjct: 387 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 441
Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
+T+G+ + +G+FIPS+ +GA GRL G+ + S+ + A PG
Sbjct: 442 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 501
Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
YA++GAAA LGG+ RMT+SL VIM E T + Y P+M MT+K V D EG+YD H
Sbjct: 502 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 561
Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
I+L PFL + +H A +VM + P+ + ++ + V + ++S+T ++
Sbjct: 562 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 618
Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
GFPVV + RL G +LR LI+ +++ + G+V + F + P P
Sbjct: 619 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 670
Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
P T+ L ++ SP+TV + V +FR LGLR +V N +++
Sbjct: 671 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 720
Query: 780 GLVTRKDLARY 790
G++T+KD+ ++
Sbjct: 721 GIITKKDVLKH 731
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 253 bits (647), Expect = 4e-67
Identities = 220/727 (30%), Positives = 338/727 (46%), Gaps = 115/727 (15%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI----------------------- 163
WV+ LIG+L G +A ID+ V+ + LK V
Sbjct: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
Query: 164 --DKFTE------KGGLSFSL-----LLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
K++E +G ++ L +LWA L F + +V P A GSGIP+IK
Sbjct: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALL---FAFLAVSLVRVFAPYACGSGIPEIK 187
Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLK 270
L+G I + TL+IK ++L V GL++GKEGP++H S S
Sbjct: 188 TILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFS---- 243
Query: 271 RDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 330
+Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++ WR FFA
Sbjct: 244 ------KYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFA 297
Query: 331 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA 390
++++ FTL ++ + L+ F + + + E+ FI +GV GG+ G
Sbjct: 298 ALVAAFTLR--------SINPFGNSRLVLF--YVEYHTPWYMAELFPFILLGVFGGLWGT 347
Query: 391 VFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYP 449
+F N W + + + V+E ++V A+TA +A+ Y+ + L
Sbjct: 348 LFIRCNIAWCRRRKTTRLGK--YPVLEVIVVTAITAIIAYPNPYTRQSTSELIS------ 399
Query: 450 LQLFCADGEY-NSMAAAFFNTPEKS-VVSLFHDPPGSYNPLT----LGLFTLVYFFLACW 503
+LF G +S + N P + V D P T L L + + +
Sbjct: 400 -ELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIF 458
Query: 504 TYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLT--------------GAAIWADPGKYAL 549
T+G+ + +G+FIPS+ +GA GR+ GI + L A PG YA+
Sbjct: 459 TFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAM 518
Query: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQL 608
+GAAA LGG+ RMT+SL VIM E T + Y P+M +T+K V D F EG+Y+ HI L
Sbjct: 519 VGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHL 578
Query: 609 QSVPFLHWEAPVTSHSLTAREVM-----STPVTCLRRREKVGVIVDVLSDTASNHNGFPV 663
PFL + T H A +VM P++ L + V+ L +++NGFPV
Sbjct: 579 NGYPFLDVKDEFT-HRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLI-KETDYNGFPV 636
Query: 664 VEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQS 723
V D RL G R +LI+ +K+ + G+V + F + P P S
Sbjct: 637 VVSRDS---ERLIGFAQRRELILAIKN---ARQRQEGIVSNSIMY--FTEEPPEL-PANS 687
Query: 724 IHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVT 783
H + L +N SP+TV + V +FR LGLR +V +++G++T
Sbjct: 688 PH--------PLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVT-RSGRLLGIIT 738
Query: 784 RKDLARY 790
+KD+ R+
Sbjct: 739 KKDVLRH 745
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 253 bits (645), Expect = 6e-67
Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169
W++ L G+ +G +A IDI + + LK + N F E+
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
Query: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
G + +++ +F + +V P A GSGIP+IK L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
+G I + TL+IK ++L+V GL++GKEGP++H S +
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
+Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
Query: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393
+ F L ++ + L+ F + + + E+ FI +GV GG+ GA F
Sbjct: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
Query: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452
N W + + V+E ++VAA+TA +AF Y+ L + L
Sbjct: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
Query: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508
C E +S+ + +V D P G Y+ + L++ + +T+G+
Sbjct: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
Query: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554
V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA
Sbjct: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
Query: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613
LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF
Sbjct: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
Query: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667
L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+
Sbjct: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
Query: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727
+ RL G LR L + ++ + G+V F P P
Sbjct: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
Query: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
E + L ++ SP+TV + V +FR LGLR +V N +++G++T+KD+
Sbjct: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800
Query: 788 ARY 790
R+
Sbjct: 801 LRH 803
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 248 bits (634), Expect = 1e-65
Identities = 210/723 (29%), Positives = 338/723 (46%), Gaps = 107/723 (14%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169
W++ L G+ +G +A IDI + + LK + N F E+
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188
Query: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
G + +++ +F + +V P A GSGIP+IK L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
+G I + TL+IK ++L+V GL++GKEGP++H S +
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298
Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
+Y + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++ WR FFA+++
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358
Query: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393
+ F L ++ + L+ F + + + E+ FI +GV GG+ GA F
Sbjct: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408
Query: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452
N W + + V+E ++VAA+TA +AF Y+ L + L
Sbjct: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461
Query: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508
C E +S+ + +V D P G Y+ + L++ + +T+G+
Sbjct: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521
Query: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554
V +G+FIPS+ IGA GR+ GI++ L + AD PG YA++GAAA
Sbjct: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581
Query: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613
LGG+ RMT+SL VI+ E T + Y P+M +MT+K VGD F EG+Y+ HI+L PF
Sbjct: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641
Query: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667
L + T H+ A +VM + P + ++ + V I +++++T ++NGFPV+
Sbjct: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696
Query: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727
+ RL G LR L + ++ + G+V F P P
Sbjct: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743
Query: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
E + L ++ SP+TV + V +FR LGLR +V N V+G++T+K++
Sbjct: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GIVLGIITKKNI 800
Query: 788 ARY 790
+
Sbjct: 801 LEH 803
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 191 bits (486), Expect = 2e-48
Identities = 165/601 (27%), Positives = 277/601 (46%), Gaps = 60/601 (9%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLL----WATL 182
W+ L+G+L LV+ +D + + + +G L+ S+LL W T
Sbjct: 91 WIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRG----------LNTSILLQYLAWVTY 140
Query: 183 NAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGL 242
+ + + P A GSGIP++K L GV + + LKT + KV G+ ++ G+
Sbjct: 141 PVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGM 200
Query: 243 AVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFG 302
+GKEGP +H S+ AA +S+ L I+E R+TE ++A A GV F
Sbjct: 201 PLGKEGPFVHIASMCAALLSK----FLSLFGGIYENESRNTE---MLAAACAVGVGCCFA 253
Query: 303 APVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGR 362
AP+GGVLFS+E ++F+ WR FFA+ S F VL++++ + +++ F R
Sbjct: 254 APIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFR-VLAVWNRDEETITALFKTRF-R 311
Query: 363 FDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWL--TMFRIRYIHRPCL--QVIEAV 418
D + + E+P F +G+ G GA+F LN + M + + I+R + +++
Sbjct: 312 LD---FPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368
Query: 419 LVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF 478
LV + +T+ F + G +S L + E S
Sbjct: 369 LVTLLISTLTFPPGFGQ-----FMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQA 423
Query: 479 HDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGA 538
+PP + LTL +F L+ F+++ + V G F+P +IGAA+GRL G S++
Sbjct: 424 WNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPD 483
Query: 539 AIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAK 591
I D PG YA++GAAA L G V T+S VI+ E T + + P+M+ ++ A
Sbjct: 484 GIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILAN 542
Query: 592 IVGDVFIEGLYDMHIQLQSVPFL-------HWEAPVTSHSLTAREVMSTPVTCLRRREKV 644
V LYD I+++ +P+L H + V + R+V ++C R ++
Sbjct: 543 AVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRL 602
Query: 645 GVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQR 704
A + ++ + + L G I RSQ++ LL ++ R + +R
Sbjct: 603 ----------ALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQER 652
Query: 705 R 705
R
Sbjct: 653 R 653
Score = 31.6 bits (70), Expect = 3.1
Identities = 19/86 (22%), Positives = 44/86 (51%), Gaps = 2/86 (2%)
Query: 705 RLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF-MNPSPYTVPQEASLPRVFKLFRA 763
R+ L D P + + + + + ++ S+ ++P+P+ + + SL + +F
Sbjct: 753 RISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSL 812
Query: 764 LGLRHLVVVDNRNQVVGLVTRKDLAR 789
LG+ H V + +++G+VT K+L +
Sbjct: 813 LGVDH-AYVTSIGRLIGIVTLKELRK 837
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 183 bits (464), Expect = 6e-46
Identities = 161/583 (27%), Positives = 267/583 (45%), Gaps = 44/583 (7%)
Query: 127 WVICALIGILTGLVACFIDIV-VENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAA 185
W+ L+G+L LV+ +D V ++L K+ + + L L+W T
Sbjct: 118 WIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLV 170
Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG 245
+L ++ I P A GSGIP++K L GV + + +K V KV + + G+ VG
Sbjct: 171 LILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVG 230
Query: 246 KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPV 305
KEGP +H S+ AA +S+ S + + D ++ G A GV FG P+
Sbjct: 231 KEGPFVHIASICAAVLSKFMSV-------FCGVYEQPYYYSDILTVGCAVGVGCCFGTPL 283
Query: 306 GGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDS 365
GGVLFS+E ++++ WR FFA+ S F VL++++ + +++ NF R D
Sbjct: 284 GGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR-VLAVWNKDAVTITALFRTNF-RMD- 340
Query: 366 EKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVI--EAVLVAAV 423
+ + E+P F A+G+ G+LGAVF L+ + M +R H+ Q + +L +
Sbjct: 341 --FPFDLKELPAFAAIGICCGLLGAVFVYLHRQV-MLGVRK-HKALSQFLAKHRLLYPGI 396
Query: 424 TATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPG 483
V + Q + G M D N+ PE S P
Sbjct: 397 VTFVIASFTFPPGMGQFMAGELMPREAISTLFD---NNTWVKHAGDPESLGQSAVWIHPR 453
Query: 484 SYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD 543
+ + LF ++ F+++ + + G F+P ++GAA+GRL G ++ L I D
Sbjct: 454 VNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFD 513
Query: 544 -------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDV 596
PG YA++GAAA L G V T+S VI E T + + P+M+ ++ A +V
Sbjct: 514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQS 572
Query: 597 FIEGLYDMHIQLQSVPF---LHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSD 653
LYD IQ++ +P+ L W ++ +++ ++M V + G + +L
Sbjct: 573 LQPSLYDSIIQVKKLPYLPDLGWN-QLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQT 631
Query: 654 TASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 696
T P+V+ D L G + RS+L LL+ + ER
Sbjct: 632 TTV--KTLPLVDSKDS---MILLGSVERSELQALLQRHLCPER 669
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 179 bits (453), Expect = 1e-44
Identities = 93/189 (49%), Positives = 128/189 (67%), Gaps = 1/189 (0%)
Query: 94 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 274 KIFEYFRRD 282
F YFR D
Sbjct: 227 FNFPYFRSD 235
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 179 bits (453), Expect = 1e-44
Identities = 93/189 (49%), Positives = 128/189 (67%), Gaps = 1/189 (0%)
Query: 94 YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
YESLDYD N +LE +++ R E +W++ IG+ TGLV F+D V
Sbjct: 48 YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107
Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
LK+ V++ ++++ ++KG L+ SLL N FV + S++V IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166
Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226
Query: 274 KIFEYFRRD 282
F YFR D
Sbjct: 227 FNFPYFRSD 235
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 167 bits (422), Expect = 5e-41
Identities = 172/690 (24%), Positives = 299/690 (43%), Gaps = 103/690 (14%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
W +G+L LV+C +D+ VE+ V++ + + E G L W A
Sbjct: 50 WYFLMTLGVLMALVSCAMDLAVES-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
V S I P + GSGIP++K L GV + + +K KV G+ ++ G L
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLF 162
Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
+GK GP +H ++AA + + R+T++ +++ + + A AA GV+ F A
Sbjct: 163 LGKVGPFVHLSVMMAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215
Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
P GVLFS+E +S ++ + WR FFA+ F +L++++ ++S +F R
Sbjct: 216 PFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFR-LLAVFNSEQETITSLYKTSF-RV 273
Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVF-NALNYWLTMFRIRYIHRPCLQVIEAVLVAA 422
D + + + EI F+A+G + G+LG+ + + R L + V A
Sbjct: 274 D---VPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSAL 330
Query: 423 VTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPP 482
T L+ +S P G ++ L + + F+ ++++ PP
Sbjct: 331 AT------LVLASITYPPSAGRFLASRLSM-------KQHLDSLFDNHSWALMTQNSSPP 377
Query: 483 GS------------YNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWG 525
Y+P TL F ++ F++ + + AG F+P + GAA G
Sbjct: 378 WPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIG 437
Query: 526 RLFGISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVT 578
RLFG +LS++ I A PG YAL GAAA G V T+S ++ E T +
Sbjct: 438 RLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAA-FSGAVTHTISTALLAFEVTGQIV 496
Query: 579 YGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVT 636
+ P+++ ++ A + YD + ++ +P+L + SH + M+ +T
Sbjct: 497 HALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSIT 556
Query: 637 CLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 696
L + + +V V+ T+++ +P+VE T+ L G++ R+QL+ LK +
Sbjct: 557 TLAKDMPLEEVVKVV--TSTDVAKYPLVE---STESQILVGIVRRAQLVQALKAEP---- 607
Query: 697 SNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPS-PYT--VPQEAS 753
P + P ++C D+ P+ P T + E S
Sbjct: 608 -------------------PSWAP--------GHQQCLQDILAAGCPTEPVTLKLSPETS 640
Query: 754 LPRVFKLFRALGLRHLVVVDNRNQVVGLVT 783
L LF L L H + V +R + VG V+
Sbjct: 641 LHEAHNLFELLNL-HSLFVTSRGRAVGCVS 669
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 147 bits (371), Expect = 4e-35
Identities = 166/686 (24%), Positives = 292/686 (42%), Gaps = 95/686 (13%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
W +G+L LV+ ++ + V++ + + E G L W A
Sbjct: 50 WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
V S I P + GSGIP++K L GV + + +K KV G+ ++ G L
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
+GK GP +H +IAA + + R+T++ +++ + + A AA GV+ F A
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215
Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
P GVLFS+E +S ++ WR FFA+ F +L++++ ++S +F R
Sbjct: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273
Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 415
D + + + EI F+A+G + GVL + F ++ +P +
Sbjct: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330
Query: 416 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 474
+L+A++T +SR SM L LF D ++ + P
Sbjct: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381
Query: 475 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 529
+ H Y+P TL F ++ F++ + + AG F+P ++GAA GRL G
Sbjct: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441
Query: 530 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 582
+L+ I PG YAL GAAA G V T+S ++ E T + + P
Sbjct: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500
Query: 583 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 640
+++ ++ A + YD I ++ +P+L + SH + M+ +T L +
Sbjct: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLG 700
+ +V V+ T+++ +P+VE T+ L G++ R+QL+ L+ +
Sbjct: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQAE--------- 606
Query: 701 LVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF---MNPSPYTVPQEASLPRV 757
PP + + ++C D+ P T+ E +L +
Sbjct: 607 ------------------PPSR----APGHQQCLQDILARGCPTEPVTLTLFSETTLHQA 644
Query: 758 FKLFRALGLRHLVVVDNRNQVVGLVT 783
LF+ L L+ L V +R + VG V+
Sbjct: 645 QNLFKLLNLQSLFVT-SRGRAVGCVS 669
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 146 bits (369), Expect = 7e-35
Identities = 148/589 (25%), Positives = 260/589 (44%), Gaps = 60/589 (10%)
Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
W +G+L LV+ ++ + V++ + + E G L W A
Sbjct: 50 WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
V S I P + GSGIP++K L GV + + +K KV G+ ++ G L
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
+GK GP +H +IAA + + R+T++ +++ + + A AA GV+ F A
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215
Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
P GVLFS+E +S ++ WR FFA+ F +L++++ ++S +F R
Sbjct: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273
Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 415
D + + + EI F+A+G + GVL + F ++ +P +
Sbjct: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330
Query: 416 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 474
+L+A++T +SR SM L LF D ++ + P
Sbjct: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381
Query: 475 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 529
+ H Y+P TL F ++ F++ + + AG F+P ++GAA GRL G
Sbjct: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441
Query: 530 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 582
+L+ I PG YAL GAAA G V T+S ++ E T + + P
Sbjct: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500
Query: 583 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 640
+++ ++ A + YD I ++ +P+L + SH + M+ +T L +
Sbjct: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLK 689
+ +V V+ T+++ +P+VE T+ L G++ R+QL+ L+
Sbjct: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQ 604
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 32.0 bits (71), Expect = 2.3
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)
Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
M++ + C E N+ AF + PE++ + + H G+ + LT+
Sbjct: 724 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 783
Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
LF+ ++ F+ W + V+ S L WG + L ++ WA+ K L
Sbjct: 784 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 835
Query: 550 MGAAAQLGGIVRMTLSLTV 568
+ A L IV+ T LT+
Sbjct: 836 LAADCHLSRIVQATTLLTM 854
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 32.0 bits (71), Expect = 2.3
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)
Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
M++ + C E N+ AF + PE++ + + H G+ + LT+
Sbjct: 725 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 784
Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
LF+ ++ F+ W + V+ S L WG + L ++ WA+ K L
Sbjct: 785 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 836
Query: 550 MGAAAQLGGIVRMTLSLTV 568
+ A L IV+ T LT+
Sbjct: 837 LAADCHLSRIVQATTLLTM 855
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 32.0 bits (71), Expect = 2.3
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)
Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
M++ + C E N+ AF + PE++ + + H G+ + LT+
Sbjct: 709 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 768
Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
LF+ ++ F+ W + V+ S L WG + L ++ WA+ K L
Sbjct: 769 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 820
Query: 550 MGAAAQLGGIVRMTLSLTV 568
+ A L IV+ T LT+
Sbjct: 821 LAADCHLSRIVQATTLLTM 839
>gi|18702331 OTU domain containing 7A [Homo sapiens]
Length = 926
Score = 32.0 bits (71), Expect = 2.3
Identities = 21/68 (30%), Positives = 26/68 (38%)
Query: 27 TARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHN 86
TA PGGG + +GP R P A V H+ + DE P + P N
Sbjct: 742 TASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQN 801
Query: 87 EKLLSLKY 94
L S Y
Sbjct: 802 RSLSSQSY 809
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 32.0 bits (71), Expect = 2.3
Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 18/76 (23%)
Query: 18 EEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPD---MD 74
EE L PG G+ LL+GA P ++P +DE P D
Sbjct: 1433 EEMKCCLPDDGGPGAGSFLLHGASPPLLHRAP---------------EDEAAGPPGDACD 1477
Query: 75 PPHPFPKEIPHNEKLL 90
P PFP +PH LL
Sbjct: 1478 IPPPFPNLLPHRPPLL 1493
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 31.2 bits (69), Expect = 4.0
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
RE + ++ L +++N +E ++ +L+ LIL L++ L VF V ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185
Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
L L RL++ F I I + ++ CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,442,108
Number of Sequences: 37866
Number of extensions: 1314243
Number of successful extensions: 4309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 4186
Number of HSP's gapped (non-prelim): 56
length of query: 805
length of database: 18,247,518
effective HSP length: 110
effective length of query: 695
effective length of database: 14,082,258
effective search space: 9787169310
effective search space used: 9787169310
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.