BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo sapiens] (461 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 936 0.0 gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 538 e-153 gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 537 e-153 gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 244 1e-64 gi|194328806 nuclear receptor subfamily 1, group H, member 3 iso... 231 1e-60 gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 206 5e-53 gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52 gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 204 1e-52 gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 202 7e-52 gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 199 6e-51 gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 197 1e-50 gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 197 1e-50 gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49 gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49 gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 194 2e-49 gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 191 1e-48 gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 185 9e-47 gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 180 3e-45 gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 175 7e-44 gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 175 9e-44 gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 170 3e-42 gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 165 9e-41 gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 164 2e-40 gi|11415052 retinoid X receptor, beta [Homo sapiens] 160 2e-39 gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 158 9e-39 gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] 154 1e-37 gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] 154 2e-37 gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] 154 2e-37 gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] 154 2e-37 gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 152 8e-37 >gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo sapiens] Length = 461 Score = 936 bits (2418), Expect = 0.0 Identities = 461/461 (100%), Positives = 461/461 (100%) Query: 1 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW 60 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW Sbjct: 1 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW 60 Query: 61 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA Sbjct: 61 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120 Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS Sbjct: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180 Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK Sbjct: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240 Query: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ Sbjct: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300 Query: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM Sbjct: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360 Query: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR Sbjct: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420 Query: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE Sbjct: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461 >gi|194294517 nuclear receptor subfamily 1, group H, member 3 isoform a [Homo sapiens] Length = 447 Score = 538 bits (1387), Expect = e-153 Identities = 287/461 (62%), Positives = 339/461 (73%), Gaps = 29/461 (6%) Query: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62 P S+++ PG A S + +EE P G V G + A Sbjct: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71 Query: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120 P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G Sbjct: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130 Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180 Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ + Sbjct: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189 Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240 S P ++S P P QL+ Q MI++LVAAQ QCN+ Sbjct: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226 Query: 241 RSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQ 300 RSFSD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQ Sbjct: 227 RSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQ 286 Query: 301 IALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAM 360 IALLK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM Sbjct: 287 IALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAM 346 Query: 361 RRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPR 420 L L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPR Sbjct: 347 NELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPR 406 Query: 421 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE Sbjct: 407 MLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 447 >gi|194294519 nuclear receptor subfamily 1, group H, member 3 isoform c [Homo sapiens] Length = 402 Score = 537 bits (1383), Expect = e-153 Identities = 273/398 (68%), Positives = 319/398 (80%), Gaps = 25/398 (6%) Query: 64 DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY 123 +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G Y Sbjct: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA--HY 87 Query: 124 ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQ 183 C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ + S Sbjct: 88 ICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSL 147 Query: 184 SPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSF 243 P ++S P P QL+ Q MI++LVAAQ QCN+RSF Sbjct: 148 PP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNRRSF 184 Query: 244 SDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIAL 303 SD+ +VTPWP+ DP SR+ARQQRFAHFTELAI+SVQEIVDFAKQ+PGFLQL REDQIAL Sbjct: 185 SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIAL 244 Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363 LK S IE+MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L Sbjct: 245 LKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNEL 304 Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423 L+DAE+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLM Sbjct: 305 QLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLM 364 Query: 424 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE Sbjct: 365 KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 402 >gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo sapiens] Length = 472 Score = 244 bits (623), Expect = 1e-64 Identities = 142/390 (36%), Positives = 215/390 (55%), Gaps = 28/390 (7%) Query: 70 ERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGG 129 ++ R A ++ G ELC VCGD+ASG+HYN L+CEGCKGFFRRS+ + Y C+ GG Sbjct: 110 KKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAV--YKCKNGG 167 Query: 130 TCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQ 189 C MD +MRRKCQ+CRLRKCKE GM +C+L+E Q + K++RK +Q + Q Sbjct: 168 NCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHAD---------Q 218 Query: 190 GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKV 249 + + G + S E +LT Q+ ++ ++ + NK+ + + Sbjct: 219 TVNEDSEGRDL----RQVTSTTKSCREKTELTPDQQTLLHFIMDSY---NKQRMPQE--I 269 Query: 250 TPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTI 309 T L + + ++ F TE+A VQ +V+F K++PGF L EDQIALLK S + Sbjct: 270 TNKIL----KEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAV 325 Query: 310 EIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAE 369 E M L +A +N + ++ +G+ E+I P+F F +++ L + E Sbjct: 326 EAMFLRSAEIFNKKLPS----GHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEE 381 Query: 370 YALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLR 429 YALL AI I S DR +++ VE LQ+P ++ L +I +P++ F +L +L LR Sbjct: 382 YALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELR 441 Query: 430 TLSSVHSEQVFALRLQDKKLPPLLSEIWDV 459 T + H+E + + R+ D K PLL EIWDV Sbjct: 442 TFNHHHAEMLMSWRVNDHKFTPLLCEIWDV 471 >gi|194328806 nuclear receptor subfamily 1, group H, member 3 isoform b [Homo sapiens] Length = 387 Score = 231 bits (589), Expect = 1e-60 Identities = 117/153 (76%), Positives = 133/153 (86%) Query: 309 IEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368 + +MLLET+RRYN +E ITFLKDF+Y+++DF +AGLQVEFINPIFEFSRAM L L+DA Sbjct: 235 VTVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDA 294 Query: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSL 428 E+ALLIAI+IFSADRPNVQ+ +VE LQ YVEAL +Y I P D+L FPRMLMKLVSL Sbjct: 295 EFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSL 354 Query: 429 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 461 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE Sbjct: 355 RTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE 387 Score = 211 bits (537), Expect = 1e-54 Identities = 120/250 (48%), Positives = 153/250 (61%), Gaps = 29/250 (11%) Query: 4 PTTSSLDTPLPGNGPPQPGAPSSSPTV-KEEGPEPWPGGPDPDVPGTDEASSACSTDWVI 62 P S+++ PG A S + +EE P G V G + A Sbjct: 13 PPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGV-GLEAAEPTALLTRAE 71 Query: 63 P--DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120 P +P E +KRKKGPAPKMLG+ELC VCGDKASGFHYNVLSCEGCKGFFRRSV++G Sbjct: 72 PPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGA- 130 Query: 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQS 180 Y C GG C MD +MRRKCQ+CRLRKC++AGMRE+CVLSEEQIR KK+++Q+++++ + Sbjct: 131 -HYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHA 189 Query: 181 QSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNK 240 S P ++S P P QL+ Q MI++LVAAQ QCN+ Sbjct: 190 TSLPP-------RASSPPQILP----------------QLSPEQLGMIEKLVAAQQQCNR 226 Query: 241 RSFSDQPKVT 250 RSFSD+ +VT Sbjct: 227 RSFSDRLRVT 236 >gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] Length = 454 Score = 206 bits (523), Expect = 5e-53 Identities = 138/454 (30%), Positives = 222/454 (48%), Gaps = 65/454 (14%) Query: 14 PGNGPPQPGAPSSSPTVKEEGPE------PWPGGPDPDVPGTDEASSACSTDWVIPDPEE 67 PG+G P G P + P P + G PD+P + ++ S + EE Sbjct: 16 PGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLP---KEMASLSVETQSTSSEE 72 Query: 68 EPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRG 127 P P++ ++ C VC DK+SG+HY V SCEGCKGFFRRS+ + Y C Sbjct: 73 MVPSSPSPPPPPRV--YKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMV--YTCHR 128 Query: 128 GGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVG 187 C ++ R +CQ CRL+KC E GM ++ V ++ +KK+++++ +S S Sbjct: 129 DKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS----- 183 Query: 188 PQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQP 247 PQ +++L+ + ++ +F Sbjct: 184 PQ--------------------------------------LEELITKVSKAHQETFPSLC 205 Query: 248 KVTPWPLGADPQSRDARQQR----FAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIAL 303 ++ + + S D R Q + F+ELA + +IV+FAK++PGF L DQI L Sbjct: 206 QLGKYTTNS---SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITL 262 Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363 LKA+ ++I++L RY E + +TF T ++ H AG + +F F+ + L Sbjct: 263 LKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPL 321 Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423 +DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +RP FPRMLM Sbjct: 322 EMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLM 381 Query: 424 KLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456 K+ LR +S+ +E+ L+++ +PPL+ E+ Sbjct: 382 KITDLRGISTKGAERAITLKMEIPGPMPPLIREM 415 >gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] Length = 462 Score = 204 bits (519), Expect = 1e-52 Identities = 145/474 (30%), Positives = 226/474 (47%), Gaps = 76/474 (16%) Query: 6 TSSLDTPLPGNG--------------PPQPGA---PSSSPTVKEEGPEPWPGGPDPDVPG 48 ++S P PG G PP G P + T++ + P P P Sbjct: 3 SNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIE 62 Query: 49 TDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCK 108 T +SS + ++P P P P P++ ++ C VC DK+SG+HY V +CEGCK Sbjct: 63 TQSSSS----EEIVPSPPSPP-------PLPRI--YKPCFVCQDKSSGYHYGVSACEGCK 109 Query: 109 GFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKK 168 GFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V ++ +KK Sbjct: 110 GFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK 167 Query: 169 KIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228 ++ K P+ S S P E G +L Sbjct: 168 EVPK---------------PECSESYTLTP-------EVG----------ELIEKVRKAH 195 Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288 Q+ A Q K + ++ + Q + F+EL+ + + V+FAKQ Sbjct: 196 QETFPALCQLGKYTTNNSSE----------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 245 Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVE 348 +PGF L DQI LLKA+ ++I++L RY E + +TF T ++ H AG Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 304 Query: 349 FINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR 408 + +F F+ + L +DDAE LL AI + DR ++++P RV+ LQ+P +EAL Y R Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364 Query: 409 IKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461 +RP FP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E Sbjct: 365 KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418 >gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] Length = 462 Score = 204 bits (519), Expect = 1e-52 Identities = 145/474 (30%), Positives = 226/474 (47%), Gaps = 76/474 (16%) Query: 6 TSSLDTPLPGNG--------------PPQPGA---PSSSPTVKEEGPEPWPGGPDPDVPG 48 ++S P PG G PP G P + T++ + P P P Sbjct: 3 SNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIE 62 Query: 49 TDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCK 108 T +SS + ++P P P P P++ ++ C VC DK+SG+HY V +CEGCK Sbjct: 63 TQSSSS----EEIVPSPPSPP-------PLPRI--YKPCFVCQDKSSGYHYGVSACEGCK 109 Query: 109 GFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKK 168 GFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V ++ +KK Sbjct: 110 GFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK 167 Query: 169 KIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228 ++ K P+ S S P E G +L Sbjct: 168 EVPK---------------PECSESYTLTP-------EVG----------ELIEKVRKAH 195 Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288 Q+ A Q K + ++ + Q + F+EL+ + + V+FAKQ Sbjct: 196 QETFPALCQLGKYTTNNSSE----------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQ 245 Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVE 348 +PGF L DQI LLKA+ ++I++L RY E + +TF T ++ H AG Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-P 304 Query: 349 FINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR 408 + +F F+ + L +DDAE LL AI + DR ++++P RV+ LQ+P +EAL Y R Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364 Query: 409 IKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461 +RP FP+MLMK+ LR++S+ +E+V L+++ +PPL+ E+ + E Sbjct: 365 KRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 418 >gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] Length = 457 Score = 202 bits (513), Expect = 7e-52 Identities = 141/450 (31%), Positives = 221/450 (49%), Gaps = 66/450 (14%) Query: 13 LPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERK 72 LP G P PG P S+P P G + + + + S++ ++P P P Sbjct: 29 LPEKGLPAPG-PYSTPL-----RTPLWNGSNHSIE-----TQSSSSEEIVPSPPSPP--- 74 Query: 73 RKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQ 132 P P++ ++ C VC DK+SG+HY V +CEGCKGFFRRS+ + Y C C Sbjct: 75 ----PLPRI--YKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMV--YTCHRDKNCI 126 Query: 133 MDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSS 192 ++ R +CQ CRL+KC E GM ++ V ++ +KK++ K P+ S Sbjct: 127 INKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPK---------------PECSE 171 Query: 193 SSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPW 252 S P E G +L Q+ A Q K + ++ + Sbjct: 172 SYTLTP-------EVG----------ELIEKVRKAHQETFPALCQLGKYTTNNSSE---- 210 Query: 253 PLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIM 312 Q + F+EL+ + + V+FAKQ+PGF L DQI LLKA+ ++I+ Sbjct: 211 ------QRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDIL 264 Query: 313 LLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYAL 372 +L RY E + +TF T ++ H AG + +F F+ + L +DDAE L Sbjct: 265 ILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFANQLLPLEMDDAETGL 323 Query: 373 LIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLS 432 L AI + DR ++++P RV+ LQ+P +EAL Y R +RP FP+MLMK+ LR++S Sbjct: 324 LSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSIS 383 Query: 433 SVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461 + +E+V L+++ +PPL+ E+ + E Sbjct: 384 AKGAERVITLKMEIPGSMPPLIQEMLENSE 413 >gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] Length = 443 Score = 199 bits (505), Expect = 6e-51 Identities = 130/420 (30%), Positives = 206/420 (49%), Gaps = 64/420 (15%) Query: 42 PDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNV 101 P P + E S S + V P P P ++ C VC DK+SG+HY V Sbjct: 44 PQPASLQSVETQSTSSEEMVPSSPS----------PPPPPRVYKPCFVCNDKSSGYHYGV 93 Query: 102 LSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLS 161 SCEGCKGFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V + Sbjct: 94 SSCEGCKGFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRN 151 Query: 162 EEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLT 221 + +KK+++++ +S S PQ Sbjct: 152 DRNKKKKEVKEEGSPDSYELS-----PQ-------------------------------- 174 Query: 222 AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR----FAHFTELAII 277 +++L+ + ++ +F ++ + + S D R Q + F+ELA Sbjct: 175 ------LEELITKVSKAHQETFPSLCQLGKYTTNS---SADHRVQLDLGLWDKFSELATK 225 Query: 278 SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSK 337 + +IV+FAK++PGF L DQI LLKA+ ++I++L RY E + +TF T ++ Sbjct: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285 Query: 338 DDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ 397 H AG + +F F+ + L +DD E LL AI + DR +++EP +V+ LQ+ Sbjct: 286 TQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQE 344 Query: 398 PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456 P +EAL Y R +RP FPRMLMK+ LR +S+ +E+ L+++ +PPL+ E+ Sbjct: 345 PLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404 >gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo sapiens] Length = 427 Score = 197 bits (502), Expect = 1e-50 Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%) Query: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145 +C VCGD+A+GFH+N ++CEGCKGFFRRS+ R + C G C++ RR CQ CR Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80 Query: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189 L++C + GM ++ +L++E++++K+ I K++++E+ S P + Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140 Query: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228 G S S P + S +G S + +T++ M+ Sbjct: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197 Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288 + L ++ SD P VT ++ H +L S+Q+++ FAK Sbjct: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247 Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347 +PGF L EDQI LLK+S IE+++L + + + T +D+ Y D +AG + Sbjct: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307 Query: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407 E I P+ +F +++L L + E+ LL+AI I S DRP VQ+ +EA+Q L +Y Sbjct: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367 Query: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457 R + P L + +M+ KL LR+L+ HS+Q L Q + KL PL+ E++ Sbjct: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422 >gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo sapiens] Length = 427 Score = 197 bits (502), Expect = 1e-50 Identities = 128/415 (30%), Positives = 209/415 (50%), Gaps = 58/415 (13%) Query: 86 LCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCR 145 +C VCGD+A+GFH+N ++CEGCKGFFRRS+ R + C G C++ RR CQ CR Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKAL--FTCPFNGDCRITKDNRRHCQACR 80 Query: 146 LRKCKEAGMREQCVLSEEQIRKKK--IRKQQQQESQSQSQSPVGPQ-------------- 189 L++C + GM ++ +L++E++++K+ I K++++E+ S P + Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHH 140 Query: 190 ---------------------GSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMI 228 G S S P + S +G S + +T++ M+ Sbjct: 141 KTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHC-ITSSD--MM 197 Query: 229 QQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQ 288 + L ++ SD P VT ++ H +L S+Q+++ FAK Sbjct: 198 DSSSFSNLDLSEED-SDDPSVT---------LELSQLSMLPHLADLVSYSIQKVIGFAKM 247 Query: 289 VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITF-LKDFTYSKDDFHRAGLQV 347 +PGF L EDQI LLK+S IE+++L + + + T +D+ Y D +AG + Sbjct: 248 IPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSL 307 Query: 348 EFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYT 407 E I P+ +F +++L L + E+ LL+AI I S DRP VQ+ +EA+Q L +Y Sbjct: 308 ELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYI 367 Query: 408 RIKRPQ--DQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDK---KLPPLLSEIW 457 R + P L + +M+ KL LR+L+ HS+Q L Q + KL PL+ E++ Sbjct: 368 RCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVF 422 >gi|189491771 thyroid hormone receptor, beta [Homo sapiens] Length = 461 Score = 194 bits (492), Expect = 2e-49 Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%) Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126 + E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+ Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146 Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184 G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206 Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244 +G + + + E + E + KR F Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246 Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304 + + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305 Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364 K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++ Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364 Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424 LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424 Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458 + LR + + H+ + ++++ + PPL E+++ Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460 >gi|189491769 thyroid hormone receptor, beta [Homo sapiens] Length = 461 Score = 194 bits (492), Expect = 2e-49 Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%) Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126 + E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+ Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146 Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184 G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206 Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244 +G + + + E + E + KR F Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246 Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304 + + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305 Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364 K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++ Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364 Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424 LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424 Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458 + LR + + H+ + ++++ + PPL E+++ Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460 >gi|40806162 thyroid hormone receptor, beta [Homo sapiens] Length = 461 Score = 194 bits (492), Expect = 2e-49 Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%) Query: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126 + E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+ Sbjct: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146 Query: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184 G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q Sbjct: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206 Query: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244 +G + + + E + E + KR F Sbjct: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246 Query: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304 + + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL Sbjct: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305 Query: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364 K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++ Sbjct: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364 Query: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424 LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK Sbjct: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424 Query: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458 + LR + + H+ + ++++ + PPL E+++ Sbjct: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460 >gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] Length = 448 Score = 191 bits (485), Expect = 1e-48 Identities = 123/411 (29%), Positives = 208/411 (50%), Gaps = 57/411 (13%) Query: 53 SSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFR 112 + + S++ ++P P P P ++ C VC DK+SG+HY V +CEGCKGFFR Sbjct: 56 TQSTSSEELVPSPPS---------PLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFR 106 Query: 113 RSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRK 172 RS+ + Y C C ++ R +CQ CRL+KC E GM S+E +R + +K Sbjct: 107 RSIQKNMI--YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGM------SKESVRNDRNKK 158 Query: 173 QQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLV 232 +++ Q ++S ++TA + + +++ Sbjct: 159 KKETSKQECTES---------------------------------YEMTAELDDLTEKIR 185 Query: 233 AAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR-FAHFTELAIISVQEIVDFAKQVPG 291 A ++ +F ++ + + R + F+ELA + +IV+FAK++PG Sbjct: 186 KA----HQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPG 241 Query: 292 FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFIN 351 F L DQI LLKA+ ++I++L RY E + +TF T ++ H AG + Sbjct: 242 FTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTD 300 Query: 352 PIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKR 411 +F F+ + L +DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +R Sbjct: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360 Query: 412 PQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEIWDVHE 461 P FP++LMK+ LR++S+ +E+V L+++ +PPL+ E+ + E Sbjct: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSE 411 >gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform 3 [Homo sapiens] Length = 397 Score = 185 bits (469), Expect = 9e-47 Identities = 125/396 (31%), Positives = 211/396 (53%), Gaps = 57/396 (14%) Query: 83 GHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQ 142 G ++CRVCGDKA+G+H+NV++CEGCKGFFRR++ R R R G C++ RR+CQ Sbjct: 37 GPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGA-CEITRKTRRQCQ 95 Query: 143 QCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASP 202 CRLRKC E+GM+++ ++S+E + +++ ++++ ++ +Q P+G QG Sbjct: 96 ACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQ-PLGVQG------------ 142 Query: 203 GGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQP--KVTPWPLGAD--- 257 LT Q +MI++L+ AQ++ +FS +V+ G D Sbjct: 143 -----------------LTEEQRMMIRELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSV 185 Query: 258 ----PQSRDARQQRFA---HFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIE 310 P + ++ F+ H +++ + I+ FAK + F L EDQI+LLK + E Sbjct: 186 WNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFE 245 Query: 311 IMLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDD 367 + L +N ET EC +Y +D G Q + P+ +F +++L L + Sbjct: 246 LCQLRFNTVFNAETGTWEC----GRLSYCLEDT-AGGFQQLLLEPMLKFHYMLKKLQLHE 300 Query: 368 AEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKL 425 EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L Sbjct: 301 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 360 Query: 426 VSLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459 LR++++ H++++ LR+QD PL+ E++ + Sbjct: 361 TELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 394 >gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapiens] Length = 410 Score = 180 bits (456), Expect = 3e-45 Identities = 119/418 (28%), Positives = 201/418 (48%), Gaps = 41/418 (9%) Query: 64 DPEE------EPERKRKKGPAP---KMLGH--------ELCRVCGDKASGFHYNVLSCEG 106 DPEE + +RKRK G M G+ E C VCGDKA+G+HY ++CEG Sbjct: 13 DPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEG 72 Query: 107 CKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSE-EQI 165 CKGFFRR++ + Y+C+ C +D R +CQ CR +KC GM VL + +++ Sbjct: 73 CKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRV 132 Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225 K+K+ +Q ++ + + Q + +EA + +G + Sbjct: 133 AKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWK------ 186 Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285 +R F + P+ + P + F+ FT++ ++ +VDF Sbjct: 187 -------------QRRKFLPDD-IGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232 Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345 AK++P F +L EDQI LLK +EIM L A RY+ E++ +T + ++ GL Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292 Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405 V + IFE +++ LDD E ALL A+ + S DR + ++E Q+ Y+ A Sbjct: 293 GV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351 Query: 406 YTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWDVHE 461 Y ++ +P++LMK+ LR + + H+ + ++++ + PPL E+++ E Sbjct: 352 YVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQE 409 >gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform 2 [Homo sapiens] Length = 473 Score = 175 bits (444), Expect = 7e-44 Identities = 130/455 (28%), Positives = 223/455 (49%), Gaps = 51/455 (11%) Query: 39 PGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFH 98 P GP+ ++ + S D+V + E K ++ G ++CRVCGDKA+G+H Sbjct: 33 PRGPEANLEVRPKESWN-HADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYH 91 Query: 99 YNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQC 158 +NV++CEGCKGFFRR++ R R R G C++ RR+CQ CRLRKC E+GM+++ Sbjct: 92 FNVMTCEGCKGFFRRAMKRNARLRCPFR-KGACEITRKTRRQCQACRLRKCLESGMKKEM 150 Query: 159 VLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG--------------------- 197 ++S+E + +++ ++++ ++ +Q P+G QG + Sbjct: 151 IMSDEAVEERRALIKRKKSERTGTQ-PLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFK 209 Query: 198 ----PGASPGGSE--AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTP 251 PG G E Q E + + ++ + V+ QL+ + V Sbjct: 210 NFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLR------GEDGSVWN 263 Query: 252 WPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEI 311 + AD ++ H +++ + I+ FAK + F L EDQI+LLK + E+ Sbjct: 264 YKPPADSGGKEI-FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFEL 322 Query: 312 MLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368 L +N ET EC +Y +D G Q + P+ +F +++L L + Sbjct: 323 CQLRFNTVFNAETGTWEC----GRLSYCLED-TAGGFQQLLLEPMLKFHYMLKKLQLHEE 377 Query: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKLV 426 EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L Sbjct: 378 EYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLT 437 Query: 427 SLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459 LR++++ H++++ LR+QD PL+ E++ + Sbjct: 438 ELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 470 >gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform 1 [Homo sapiens] Length = 434 Score = 175 bits (443), Expect = 9e-44 Identities = 122/411 (29%), Positives = 207/411 (50%), Gaps = 50/411 (12%) Query: 83 GHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQ 142 G ++CRVCGDKA+G+H+NV++CEGCKGFFRR++ R R R G C++ RR+CQ Sbjct: 37 GPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR-KGACEITRKTRRQCQ 95 Query: 143 QCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG----- 197 CRLRKC E+GM+++ ++S+E + +++ ++++ ++ +Q P+G QG + Sbjct: 96 ACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQ-PLGVQGLTEEQRMMIREL 154 Query: 198 --------------------PGASPGGSE--AGSQGSGEGEGVQLTAAQELMIQQLVAAQ 235 PG G E Q E + + ++ + V+ Q Sbjct: 155 MDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQ 214 Query: 236 LQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQL 295 L+ + V + AD ++ H +++ + I+ FAK + F L Sbjct: 215 LR------GEDGSVWNYKPPADSGGKEI-FSLLPHMADMSTYMFKGIISFAKVISYFRDL 267 Query: 296 GREDQIALLKASTIEIMLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINP 352 EDQI+LLK + E+ L +N ET EC +Y +D G Q + P Sbjct: 268 PIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC----GRLSYCLED-TAGGFQQLLLEP 322 Query: 353 IFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRP 412 + +F +++L L + EY L+ AI++FS DRP V + V+ LQ+ + L SY RP Sbjct: 323 MLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRP 382 Query: 413 QDQLR--FPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459 Q R F +++ L LR++++ H++++ LR+QD PL+ E++ + Sbjct: 383 QPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 431 >gi|4826661 constitutive androstane receptor isoform 3 [Homo sapiens] Length = 348 Score = 170 bits (430), Expect = 3e-42 Identities = 115/383 (30%), Positives = 184/383 (48%), Gaps = 60/383 (15%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68 Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206 +KC +AGMR+ +LS E + ++ ++ Q++ Q+ Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103 Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266 VQL+ QE +I+ L+ A + F + P P Q Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146 Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316 HF ++ V +++ F K +P F L EDQI+LLK + +EI + Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206 Query: 317 ARRYNHETECITFL-KDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIA 375 + +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY LL A Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAA 264 Query: 376 INIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMKLVSLRTLSS 433 + +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L L LR+++ Sbjct: 265 MALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINE 324 Query: 434 VHSEQVFALRLQDKKLPPLLSEI 456 + Q+ ++ + PLL EI Sbjct: 325 AYGYQIQHIQGLSAMM-PLLQEI 346 >gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapiens] Length = 490 Score = 165 bits (417), Expect = 9e-41 Identities = 111/379 (29%), Positives = 180/379 (47%), Gaps = 39/379 (10%) Query: 64 DPEE------EPERKRKKGPAP---KMLGH--------ELCRVCGDKASGFHYNVLSCEG 106 DPEE + +RKRK G M G+ E C VCGDKA+G+HY ++CEG Sbjct: 13 DPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEG 72 Query: 107 CKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSE-EQI 165 CKGFFRR++ + Y+C+ C +D R +CQ CR +KC GM VL + +++ Sbjct: 73 CKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRV 132 Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225 K+K+ +Q ++ + + Q + +EA + +G + Sbjct: 133 AKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWK------ 186 Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285 +R F + P+ + P + F+ FT++ ++ +VDF Sbjct: 187 -------------QRRKFLPD-DIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232 Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345 AK++P F +L EDQI LLK +EIM L A RY+ E++ +T + ++ GL Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292 Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405 V + IFE +++ LDD E ALL A+ + S DR + ++E Q+ Y+ A Sbjct: 293 GV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEH 351 Query: 406 YTRIKRPQDQLRFPRMLMK 424 Y ++ +P++LMK Sbjct: 352 YVNHRKHNIPHFWPKLLMK 370 >gi|117938752 constitutive androstane receptor isoform 2 [Homo sapiens] Length = 352 Score = 164 bits (415), Expect = 2e-40 Identities = 115/387 (29%), Positives = 184/387 (47%), Gaps = 64/387 (16%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68 Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206 +KC +AGMR+ +LS E + ++ ++ Q++ Q+ Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103 Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266 VQL+ QE +I+ L+ A + F + P P Q Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146 Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316 HF ++ V +++ F K +P F L EDQI+LLK + +EI + Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206 Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371 + +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264 Query: 372 LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMKLVSLR 429 LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L L LR Sbjct: 265 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELR 324 Query: 430 TLSSVHSEQVFALRLQDKKLPPLLSEI 456 +++ + Q+ ++ + PLL EI Sbjct: 325 SINEAYGYQIQHIQGLSAMM-PLLQEI 350 >gi|11415052 retinoid X receptor, beta [Homo sapiens] Length = 533 Score = 160 bits (406), Expect = 2e-39 Identities = 123/459 (26%), Positives = 193/459 (42%), Gaps = 68/459 (14%) Query: 4 PTTSSLDTPLPGNG----PPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTD 59 P S L G+G PP P P SP PG P P PG S+ + Sbjct: 104 PLPPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQIN 163 Query: 60 WVI--------PDPEEEPERKRKKG------PAPKMLGHELCRVCGDKASGFHYNVLSCE 105 + P + +P +G P G LC +CGD++SG HY V SCE Sbjct: 164 STVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCE 223 Query: 106 GCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQI 165 GCKGFF+R++ + Y+CR C +D R +CQ CR +KC GM+ + V E Q Sbjct: 224 GCKGFFKRTIRKD--LTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQR 281 Query: 166 RKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQE 225 K K G GEG G A +E Sbjct: 282 GKDK----------------------------------------DGDGEGAG---GAPEE 298 Query: 226 LMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDF 285 + + +++ A+L ++S DQ P G S + + + + +V++ Sbjct: 299 MPVDRILEAELAVEQKS--DQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFT---LVEW 353 Query: 286 AKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGL 345 AK++P F L +DQ+ LL+A E+++ + R + I ++ H AG+ Sbjct: 354 AKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGV 413 Query: 346 QVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLS 405 F + E MR + +D E L AI +F+ D + P VE L++ +L + Sbjct: 414 GAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLET 473 Query: 406 YTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRL 444 Y + K P+ Q RF ++L++L +LR++ E +F +L Sbjct: 474 YCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKL 512 >gi|117938756 constitutive androstane receptor isoform 1 [Homo sapiens] Length = 357 Score = 158 bits (400), Expect = 9e-39 Identities = 115/392 (29%), Positives = 184/392 (46%), Gaps = 69/392 (17%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68 Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206 +KC +AGMR+ +LS E + ++ ++ Q++ Q+ Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103 Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266 VQL+ QE +I+ L+ A + F + P P Q Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146 Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316 HF ++ V +++ F K +P F L EDQI+LLK + +EI + Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206 Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371 + +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264 Query: 372 LLIAINIFS-----ADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQLRFPRMLMK 424 LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+ + ++L Sbjct: 265 LLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGL 324 Query: 425 LVSLRTLSSVHSEQVFALRLQDKKLPPLLSEI 456 L LR+++ + Q+ ++ + PLL EI Sbjct: 325 LAELRSINEAYGYQIQHIQGLSAMM-PLLQEI 355 >gi|19743903 RAR-related orphan receptor A isoform a [Homo sapiens] Length = 523 Score = 154 bits (390), Expect = 1e-37 Identities = 129/519 (24%), Positives = 228/519 (43%), Gaps = 106/519 (20%) Query: 36 EPWPGGPDPDV--PGTDEASSACSTDWVIPDPEEEPERKRKKGPAP-------------- 79 E P PDP PG+ A +A + P + ++ + PAP Sbjct: 2 ESAPAAPDPAASEPGSSGADAAAGSR---ETPLNQESARKSEPPAPVRRQSYSSTSRGIS 58 Query: 80 -------KMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQ 132 + C++CGDK+SG HY V++CEGCKGFFRRS Y+C C Sbjct: 59 VTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCL 116 Query: 133 MDAFMRRKCQQCRLRKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQ 181 +D R +CQ CRL+KC GM V +S++Q ++K ++++QQ+ Q Sbjct: 117 IDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQP 176 Query: 182 SQSPVGPQGSSSSASG------------PGASPGGSEAGS---------QGSGEGEGVQL 220 ++ + SA+G G +P GS+A S Q S + G+ + Sbjct: 177 GEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDI 236 Query: 221 T---------------------------------AAQELMIQQLVAAQLQCNKRSFSDQP 247 A E + Q + + L+ + + Sbjct: 237 NGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQ 296 Query: 248 KVTPWPLGADPQSRDARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIAL 303 ++T W + + + ++ +L I + E +V+FAK++ GF++L + DQI L Sbjct: 297 QIT-WQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVL 355 Query: 304 LKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRL 363 LKA ++E++ + R ++ + + F D Y+ D ++ +FI+ +FEF +++ + Sbjct: 356 LKAGSLEVVFIRMCRAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSM 413 Query: 364 GLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM 423 L + E AL A + SADR +QE ++E LQQ ++ L + K ++ +++ Sbjct: 414 HLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLIC 472 Query: 424 KLVSLRTLSSVHSEQVFALR-----LQDKKLPPLLSEIW 457 K+ +LR L H+E++ A + + PPL E++ Sbjct: 473 KVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELF 511 >gi|19743905 RAR-related orphan receptor A isoform d [Homo sapiens] Length = 468 Score = 154 bits (389), Expect = 2e-37 Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL Sbjct: 18 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 75 Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195 +KC GM V +S++Q ++K ++++QQ+ Q ++ + SA Sbjct: 76 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 135 Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221 +G G +P GS+A S Q S + G+ + Sbjct: 136 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 195 Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261 A E + Q + + L+ + + ++T W + Sbjct: 196 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 254 Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317 + + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ + Sbjct: 255 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 314 Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377 R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A Sbjct: 315 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 372 Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437 + SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E Sbjct: 373 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 431 Query: 438 QVFALR-----LQDKKLPPLLSEIW 457 ++ A + + PPL E++ Sbjct: 432 KLMAFKAIYPDIVRLHFPPLYKELF 456 >gi|4506577 RAR-related orphan receptor A isoform c [Homo sapiens] Length = 548 Score = 154 bits (389), Expect = 2e-37 Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL Sbjct: 98 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 155 Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195 +KC GM V +S++Q ++K ++++QQ+ Q ++ + SA Sbjct: 156 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 215 Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221 +G G +P GS+A S Q S + G+ + Sbjct: 216 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 275 Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261 A E + Q + + L+ + + ++T W + Sbjct: 276 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 334 Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317 + + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ + Sbjct: 335 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 394 Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377 R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A Sbjct: 395 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 452 Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437 + SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E Sbjct: 453 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 511 Query: 438 QVFALR-----LQDKKLPPLLSEIW 457 ++ A + + PPL E++ Sbjct: 512 KLMAFKAIYPDIVRLHFPPLYKELF 536 >gi|19743901 RAR-related orphan receptor A isoform b [Homo sapiens] Length = 556 Score = 154 bits (389), Expect = 2e-37 Identities = 116/445 (26%), Positives = 207/445 (46%), Gaps = 80/445 (17%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C++CGDK+SG HY V++CEGCKGFFRRS Y+C C +D R +CQ CRL Sbjct: 106 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAT--YSCPRQKNCLIDRTSRNRCQHCRL 163 Query: 147 RKCKEAGMREQCV----LSEEQ-------IRKKKIRKQQQQESQSQSQSPVGPQGSSSSA 195 +KC GM V +S++Q ++K ++++QQ+ Q ++ + SA Sbjct: 164 QKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISA 223 Query: 196 SG------------PGASPGGSEAGS---------QGSGEGEGVQLT------------- 221 +G G +P GS+A S Q S + G+ + Sbjct: 224 NGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPA 283 Query: 222 --------------------AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSR 261 A E + Q + + L+ + + ++T W + Sbjct: 284 SGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQIT-WQTFLQEEIE 342 Query: 262 DARQQRFAHFTELAIISVQE----IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETA 317 + + ++ +L I + E +V+FAK++ GF++L + DQI LLKA ++E++ + Sbjct: 343 NYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMC 402 Query: 318 RRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN 377 R ++ + + F D Y+ D ++ +FI+ +FEF +++ + L + E AL A Sbjct: 403 RAFDSQNNTVYF--DGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFV 460 Query: 378 IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSE 437 + SADR +QE ++E LQQ ++ L + K ++ +++ K+ +LR L H+E Sbjct: 461 LMSADRSWLQEKVKIEKLQQK-IQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTE 519 Query: 438 QVFALR-----LQDKKLPPLLSEIW 457 ++ A + + PPL E++ Sbjct: 520 KLMAFKAIYPDIVRLHFPPLYKELF 544 >gi|117938746 constitutive androstane receptor isoform 7 [Homo sapiens] Length = 339 Score = 152 bits (383), Expect = 8e-37 Identities = 105/346 (30%), Positives = 163/346 (47%), Gaps = 63/346 (18%) Query: 87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRL 146 C VCGD+A+G+H+N L+CEGCKGFFRR+V + C G+C++ RR C CRL Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRHCPACRL 68 Query: 147 RKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSE 206 +KC +AGMR+ +LS E + ++ ++ Q++ Q+ Sbjct: 69 QKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTP------------------------- 103 Query: 207 AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQ 266 VQL+ QE +I+ L+ A + F + P P Q Sbjct: 104 -----------VQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRP------PAHLFIHHQ 146 Query: 267 RF----------AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLET 316 HF ++ V +++ F K +P F L EDQI+LLK + +EI + Sbjct: 147 PLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVL 206 Query: 317 ARRYNHETECITFL-KDFTYSKDDFHR----AGLQVEFINPIFEFSRAMRRLGLDDAEYA 371 + +T+ FL Y+ +D R G QVEF+ +F F +R+L L + EY Sbjct: 207 NTTFCLQTQ--NFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYV 264 Query: 372 LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTR--IKRPQDQ 415 LL A+ +FS DRP V + ++ LQ+ L SY + +RP+D+ Sbjct: 265 LLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 310 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.133 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,109,453 Number of Sequences: 37866 Number of extensions: 1260724 Number of successful extensions: 17460 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 235 Number of HSP's successfully gapped in prelim test: 378 Number of HSP's that attempted gapping in prelim test: 13925 Number of HSP's gapped (non-prelim): 3176 length of query: 461 length of database: 18,247,518 effective HSP length: 106 effective length of query: 355 effective length of database: 14,233,722 effective search space: 5052971310 effective search space used: 5052971310 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.