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Search of human proteins with 83281200
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83281200 protogenin [Homo sapiens]
(1150 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83281200 protogenin [Homo sapiens] 2308 0.0
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 668 0.0
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 478 e-134
gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens] 339 8e-93
gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens] 337 5e-92
gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens] 336 7e-92
gi|157311649 neogenin homolog 1 [Homo sapiens] 287 4e-77
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 278 2e-74
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 218 2e-56
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 217 6e-56
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 215 2e-55
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 192 1e-48
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 191 3e-48
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 186 8e-47
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 186 1e-46
gi|222352127 sidekick 2 [Homo sapiens] 181 5e-45
gi|119220552 sidekick 1 [Homo sapiens] 177 7e-44
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 172 2e-42
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 172 2e-42
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 171 4e-42
gi|109150416 peroxidasin [Homo sapiens] 170 8e-42
gi|19743806 roundabout 1 isoform b [Homo sapiens] 169 1e-41
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 169 1e-41
gi|4506569 roundabout 1 isoform a [Homo sapiens] 169 1e-41
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 168 2e-41
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 166 1e-40
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 166 1e-40
gi|224994173 roundabout 1 isoform d [Homo sapiens] 164 3e-40
gi|224994171 roundabout 1 isoform c [Homo sapiens] 164 3e-40
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 164 3e-40
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 2308 bits (5980), Expect = 0.0
Identities = 1150/1150 (100%), Positives = 1150/1150 (100%)
Query: 1 MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC 60
MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC
Sbjct: 1 MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC 60
Query: 61 QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYG 120
QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYG
Sbjct: 61 QAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYG 120
Query: 121 AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD 180
AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD
Sbjct: 121 AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD 180
Query: 181 RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG
Sbjct: 181 RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
Query: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG
Sbjct: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
Query: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW
Sbjct: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Query: 361 LKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS 420
LKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS
Sbjct: 361 LKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS 420
Query: 421 APYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII 480
APYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII
Sbjct: 421 APYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII 480
Query: 481 DDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPI 540
DDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPI
Sbjct: 481 DDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPI 540
Query: 541 PAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLG 600
PAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLG
Sbjct: 541 PAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLG 600
Query: 601 ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQ 660
ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQ
Sbjct: 601 ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQ 660
Query: 661 QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVP 720
QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVP
Sbjct: 661 QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVP 720
Query: 721 PPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHM 780
PPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHM
Sbjct: 721 PPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHM 780
Query: 781 LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW 840
LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW
Sbjct: 781 LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW 840
Query: 841 KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE 900
KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE
Sbjct: 841 KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE 900
Query: 901 VGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALT 960
VGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALT
Sbjct: 901 VGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALT 960
Query: 961 CILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMP 1020
CILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMP
Sbjct: 961 CILICVLILIYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEESLMP 1020
Query: 1021 MIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQP 1080
MIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQP
Sbjct: 1021 MIMPNSFIDAKGGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQP 1080
Query: 1081 GTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLS 1140
GTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLS
Sbjct: 1081 GTTVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGSHETGDSGRFSHESNDEIHLS 1140
Query: 1141 SVISTTPPNL 1150
SVISTTPPNL
Sbjct: 1141 SVISTTPPNL 1150
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [Homo
sapiens]
Length = 1250
Score = 668 bits (1724), Expect = 0.0
Identities = 393/992 (39%), Positives = 548/992 (55%), Gaps = 63/992 (6%)
Query: 38 ELSFVKEPQDVTVTRKDPVVLDCQ---AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLY 94
ELS P V + + VL+C A P +VTW K+G + E+ + +L NGSL+
Sbjct: 35 ELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLW 94
Query: 95 ISEVEGRRGEQSD--------EGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEV 146
+S+ G EG Y CLA G + SQ A + L+T++ F + P S V
Sbjct: 95 LSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTV 154
Query: 147 HEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCI 206
E G ARF C I P +ITWE ++ TLP R+ LP GVLQI DV + D+G YRC+
Sbjct: 155 EENGTARFECHIEGLPAPIITWEKDQVTLPEE-PRLIVLPNGVLQILDVQESDAGPYRCV 213
Query: 207 AATVAHRRKSMEASLTVIP--AKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264
A A + S EA L+V + S I+A P+N T Q+VV+EC+A+ +P P
Sbjct: 214 ATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTP 273
Query: 265 IISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVL 324
+SW R D K I + VLG NL+I++ + H+GVYVCRA P TR+F A A L VL
Sbjct: 274 FVSWVRQDGKPIST-DVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVL 332
Query: 325 APPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNS--KLVI 382
A P+ + PE+L+R RA TARFVC+A G P P + WL NG + NGR+K+ LVI
Sbjct: 333 AAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVI 392
Query: 383 NQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERP 442
QI +D YQC+AENS G + A L VV+ E PSAP V A +SSSA+L+AWERP
Sbjct: 393 TQIGLQDAGYYQCVAENSAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERP 452
Query: 443 LYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGAS 502
+S+++I +S+HY KA G++N EYQ + NDTT + DLEP ++Y FY+VAY +GAS
Sbjct: 453 EMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGAS 512
Query: 503 QMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTEN 562
+ S +TL+DVP P++SL+S +P+DI ++WLP+P GQVV Y++ + L E+
Sbjct: 513 RTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVVKYKIEYGLGKED 572
Query: 563 SIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKA-TSVKAPKS 621
I E+ G + +L L+P+ VY VRI+A T G G S W HRTP P +
Sbjct: 573 QIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVPFA 632
Query: 622 PELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQEN-----------------G 664
P ++ V WQ T I GYKLY++E G +E G
Sbjct: 633 PAELKVQAKMESLVVSWQPPPHPT-QISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVG 691
Query: 665 PIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA---DQTVSTPGCVSVRDRMVPP 721
P+ L K Y L+ L P R Y V+L+A+N +DGY A +T P R P
Sbjct: 692 PVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQR--GP 749
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHML 781
P PP H++A++N+S+SI+L W++P FT +I+NYT+R +P GL+NASLV Y +S +L
Sbjct: 750 PLPPAHVHAESNSSTSIWLRWKKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDIL 809
Query: 782 VQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWK 841
+ GL+P TKYEFAV+ H + P+ VV STLP+ P+ PP ++++ + T + W
Sbjct: 810 IGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSDLRLSPLTPSTVRLHWC 869
Query: 842 PPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEV 901
PP P + Y ILY+S +W +L +G I A + L + Y K+ A EV
Sbjct: 870 PPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEV 929
Query: 902 GEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTC 961
G GPFS ++ L ++ S+S LD S+TGI VGV + L C
Sbjct: 930 GPGPFSRLQDVITLQEKLSDS--------------------LDMHSVTGIIVGVCLGLLC 969
Query: 962 ILICVLILIYRSKARKS--SASKTAQNGTQQL 991
+L C+ + RS R+S S TA G L
Sbjct: 970 LLACMCAGLRRSPHRESLPGLSSTATPGNPAL 1001
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 478 bits (1229), Expect = e-134
Identities = 266/608 (43%), Positives = 366/608 (60%), Gaps = 12/608 (1%)
Query: 2 APPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQ 61
A P RP A L P LL LLLLLL +P G+ +EL+F EP D P+VLDC+
Sbjct: 7 ASPRRPPAPLWP--RLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCR 64
Query: 62 AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRG-EQSDEGFYQCLAMNKYG 120
G P+++TW KNG ++ E+ +L+NGSL I G SDEG Y+C+A N++G
Sbjct: 65 VEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFG 124
Query: 121 AILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMD 180
++S+KA + +T+S F V P +T EGGVARF C+I P +ITWE NR + +
Sbjct: 125 LVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNE 184
Query: 181 RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
R T LP GVLQI + D G + C+A+ +A R S A LTV S ++ P I+ G
Sbjct: 185 RYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTV-SGSGSGAYKEPAILVG 243
Query: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
P+N+T ++HQT VLEC+ATGNP+PI+SWSRLD + I V +VLG GNL+ISDV +QH+G
Sbjct: 244 PENLTLTVHQTAVLECVATGNPRPIVSWSRLDGRPIGVEGIQVLGTGNLIISDVTVQHSG 303
Query: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
VYVC A PGTR A L V AP FV+ P+S++RP TA F CQA+G P P ++W
Sbjct: 304 VYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTW 363
Query: 361 LKNGRKIHSNG--RIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDR 418
LKNG+ + G R+K NS L I+ I PED+AIYQC+AENS GS + ARLTV+ +E
Sbjct: 364 LKNGQVLGPGGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTVLWAEGL 423
Query: 419 PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478
P P NV A ++SS+ + ++W PL N+ ++I Y +H KA EYQ + T +
Sbjct: 424 PGPPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAVSKSTFQH 483
Query: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWL 538
++ DLEP++ Y+FYI AY P GAS S +TL + P PP +S+ + + + W
Sbjct: 484 LVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAP-APPPLSVRVLGSSSLQLLWE 542
Query: 539 PIP--AKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATR 596
P P A++ G + YR + + S I LPGT Y L L P +VY V++ A +
Sbjct: 543 PWPRLAQHEGGFKLFYRPASKTSFTGPIL---LPGTVSSYNLSQLDPTAVYEVKLLAYNQ 599
Query: 597 VGLGESSV 604
G G ++V
Sbjct: 600 HGDGNATV 607
Score = 83.6 bits (205), Expect = 1e-15
Identities = 90/365 (24%), Positives = 150/365 (41%), Gaps = 31/365 (8%)
Query: 664 GPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPP 723
G + L + T+SG+ P + + +A N+ QA ++ + P
Sbjct: 374 GHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS-QASARLTVLWAEGL-------PG 425
Query: 724 PPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIR----CNPVGLQNASLVLYLQTSETH 779
PP ++ A + +S+ + + W P +II Y + +P L+ V S
Sbjct: 426 PPRNVRAVSVSSTEVRVSWSEPLANTKEIIGYVLHIRKAADPPELEYQEAV---SKSTFQ 482
Query: 780 MLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVS 839
LV LEP+T Y F ++ + + +S S STL EAPA PP+ V+V + + +
Sbjct: 483 HLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPAPPPLSVRV--LGSSSLQLL 540
Query: 840 WKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASN 899
W+P + + Y R A + G ++ L L VY VK+ A N
Sbjct: 541 WEPWPRLAQHEGGFKLFY--RPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYN 598
Query: 900 EVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIAL 959
+ G+G N+ V + SE D + +Q S TGI +G+ I +
Sbjct: 599 QHGDG---NATVRFVSLRGASERTALSPPCDCRKEEA------ANQTSTTGIVIGIHIGV 649
Query: 960 TCILICVLILIYRSKARKSSASKTA-QNGTQQLPRT--SASLASGNEVGKNLEGAVGNEE 1016
TCI+ CVL L++ + R Q Q PR+ + + N + G +G +E
Sbjct: 650 TCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILALNGARRGQRGQLGRDE 709
Query: 1017 SLMPM 1021
+ M
Sbjct: 710 KRVDM 714
Score = 71.2 bits (173), Expect = 5e-12
Identities = 127/581 (21%), Positives = 214/581 (36%), Gaps = 84/581 (14%)
Query: 250 QTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGV------YV 303
Q +VL+C G P I+W + + + ++ +L NG+LMI RL+ G Y
Sbjct: 57 QPIVLDCRVEGTPPVRITWRKNGVELPESTHSTLLANGSLMIRHFRLEPGGSPSDEGDYE 116
Query: 304 CRATTPG----TRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMS 359
C A +R + AT++ F P++ G ARF CQ G+P P ++
Sbjct: 117 CVAQNRFGLVVSRKARIQAATMS-----DFHVHPQATVGEEGGVARFQCQIHGLPKPLIT 171
Query: 360 WLKNGRKIHSNGRIKMYNSK--LVINQIIPEDDAIYQCMAENSQGSILSR-ARLTVVMSE 416
W KN I ++ K L I + ED I+ C+A N +S ARLTV S
Sbjct: 172 WEKNRVPIDTDNERYTLLPKGVLQITGLRAEDGGIFHCVASNIASIRISHGARLTVSGSG 231
Query: 417 DRPSAPYNVHAETMSSSAILLAWERPLY-------NSDKVIAYSVHYMKAEGLNNEEYQV 469
S Y A + + L + N ++++S + + E QV
Sbjct: 232 ---SGAYKEPAILVGPENLTLTVHQTAVLECVATGNPRPIVSWS--RLDGRPIGVEGIQV 286
Query: 470 VIGNDTTHYIIDDLEPASNYTFYIVAYMP---MGASQMSDHVTQNTLEDVPLRPPEISLT 526
+ T + II D+ + + A P + + V Q E V P IS
Sbjct: 287 L---GTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQ-HPQSISRP 342
Query: 527 SRSPTDILISWLPIPAKY----RRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLK 582
+ + P + + GQV+ RL NS + G+
Sbjct: 343 AGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTIS-----------GIG 391
Query: 583 PDSVYLVRITAATRVGLGESS-----VWTSHRTPKATSVKAPKSPELHLEPLNCTTISVR 637
P+ + + A G ++S +W +V+A ++ T + V
Sbjct: 392 PEDEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVS--------VSSTEVRVS 443
Query: 638 WQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLL------YTLSGLDPRRKYHVRLL 691
W + + +T I GY L+ ++ P L+ ++ + + +S L+P Y +
Sbjct: 444 WSEPLANTKEIIGYVLHIRKAAD----PPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIK 499
Query: 692 AYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQ 751
AY + + S P S PPP L + SSS+ L W A
Sbjct: 500 AYTP-----RGASSASVPTLASTLGEAPAPPP----LSVRVLGSSSLQLLWEPWPRLAQH 550
Query: 752 IINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYE 792
+ + P + + + L + + + L+P YE
Sbjct: 551 EGGFKLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYE 591
>gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 339 bits (870), Expect = 8e-93
Identities = 204/545 (37%), Positives = 290/545 (53%), Gaps = 58/545 (10%)
Query: 23 LLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSEN 82
LLLLL P G SEL+FV+E D + P+VL CQ GE P+ ++W ++ ++
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 83 KRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPI 142
+ ++ +GSL+++ + RR S Y C+A N+YG ++S++A + L+++S F P
Sbjct: 63 SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPE 122
Query: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202
S EV GGVARF C I P I+WE N T L R+T LP+G+L I VSQ D G
Sbjct: 123 SIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGT 182
Query: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262
YRC+A VA R S +A LT + + P I++GPQN+T ++HQT VLEC+AT +P
Sbjct: 183 YRCVAWNVASTRHSQDAQLT-LSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHP 241
Query: 263 KPIISWSRLDHKSIDVFNTRV---LGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA 319
P++SWSRLD +SI V +V L GNLMISDV +QH+GVYVC A PGT A
Sbjct: 242 WPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQG 301
Query: 320 TLTV--------------------------------------LAP---------PSFVEW 332
L V AP P FV+W
Sbjct: 302 VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW 361
Query: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNSKLVINQIIPEDD 390
P+SL++P +A F C A+G+P ++ WLKNG+ + +N R+ NS L++ + ED+
Sbjct: 362 PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDE 421
Query: 391 AIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSSSAILLAWERPLYNSDK 448
AIYQC+AENS GS + ARL V + RP P H + +L P +S
Sbjct: 422 AIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP-ACHGSLYFCHSSVLGATPP--SSRD 478
Query: 449 VIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
+I Y +H + E Q I T+ ++ +LEPA+ YT ++ AY GASQ S +
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 509 TQNTL 513
+T+
Sbjct: 539 FASTM 543
Score = 32.0 bits (71), Expect = 3.5
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 7/81 (8%)
Query: 890 VYIVKISASNEVGEGPFS-NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSM 948
+Y +K+ A N G+G S V L +P T P S ++K + +
Sbjct: 573 LYDIKLQAFNGNGDGNSSARCVSLCDVPLAT------PDGTVSTESKTGCSCSQGESSPL 626
Query: 949 TGIAVGVGIALTCILICVLIL 969
G+ VG+ + L ++IC+L L
Sbjct: 627 PGVVVGIHVGLAALIICLLCL 647
>gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 337 bits (863), Expect = 5e-92
Identities = 203/545 (37%), Positives = 289/545 (53%), Gaps = 58/545 (10%)
Query: 23 LLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSEN 82
LLLLL P G SEL+FV+E D + P+VL CQ GE P+ ++W ++ ++
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 83 KRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPI 142
+ ++ +GSL+++ + RR S Y C+A N+YG ++S++A + L+++S F P
Sbjct: 63 SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPE 122
Query: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202
S EV GGVA F C I P I+WE N T L R+T LP+G+L I VSQ D G
Sbjct: 123 SIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGT 182
Query: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262
YRC+A VA R S +A LT + + P I++GPQN+T ++HQT VLEC+AT +P
Sbjct: 183 YRCVAWNVASTRHSQDAQLT-LSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHP 241
Query: 263 KPIISWSRLDHKSIDVFNTRV---LGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA 319
P++SWSRLD +SI V +V L GNLMISDV +QH+GVYVC A PGT A
Sbjct: 242 WPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQG 301
Query: 320 TLTV--------------------------------------LAP---------PSFVEW 332
L V AP P FV+W
Sbjct: 302 VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW 361
Query: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNSKLVINQIIPEDD 390
P+SL++P +A F C A+G+P ++ WLKNG+ + +N R+ NS L++ + ED+
Sbjct: 362 PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDE 421
Query: 391 AIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSSSAILLAWERPLYNSDK 448
AIYQC+AENS GS + ARL V + RP P H + +L P +S
Sbjct: 422 AIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP-ACHGSLYFCHSSVLGATPP--SSRD 478
Query: 449 VIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
+I Y +H + E Q I T+ ++ +LEPA+ YT ++ AY GASQ S +
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 509 TQNTL 513
+T+
Sbjct: 539 FASTM 543
Score = 31.6 bits (70), Expect = 4.5
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 7/81 (8%)
Query: 890 VYIVKISASNEVGEGPFS-NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSM 948
+Y +K+ A N G+G S V L +P T P S ++K + +
Sbjct: 573 LYDIKLQAFNGNGDGNSSARCVSLRDVPLAT------PDGTVSTESKTGCSCSQGESSPL 626
Query: 949 TGIAVGVGIALTCILICVLIL 969
G+ VG+ + L ++IC+L L
Sbjct: 627 PGVVVGIHVGLAALIICLLCL 647
>gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 336 bits (862), Expect = 7e-92
Identities = 203/545 (37%), Positives = 289/545 (53%), Gaps = 58/545 (10%)
Query: 23 LLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSEN 82
LLLLL P G SEL+FV+E D + P+VL CQ GE P+ ++W ++ ++
Sbjct: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
Query: 83 KRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPI 142
+ ++ +GSL+++ + RR S Y C+A N+YG ++S++A + L+++S F P
Sbjct: 63 SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPE 122
Query: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202
S EV GGVA F C I P I+WE N T L R+T LP+G+L I VSQ D G
Sbjct: 123 SIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGT 182
Query: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262
YRC+A VA R S +A LT + + P I++GPQN+T ++HQT VLEC+AT +P
Sbjct: 183 YRCVAWNVASTRHSQDAQLT-LSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHP 241
Query: 263 KPIISWSRLDHKSIDVFNTRV---LGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA 319
P++SWSRLD +SI V +V L GNLMISDV +QH+GVYVC A PGT A
Sbjct: 242 WPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQG 301
Query: 320 TLTV--------------------------------------LAP---------PSFVEW 332
L V AP P FV+W
Sbjct: 302 VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW 361
Query: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNSKLVINQIIPEDD 390
P+SL++P +A F C A+G+P ++ WLKNG+ + +N R+ NS L++ + ED+
Sbjct: 362 PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDE 421
Query: 391 AIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSSSAILLAWERPLYNSDK 448
AIYQC+AENS GS + ARL V + RP P H + +L P +S
Sbjct: 422 AIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP-ACHGSLYFCHSSVLGATPP--SSRD 478
Query: 449 VIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
+I Y +H + E Q I T+ ++ +LEPA+ YT ++ AY GASQ S +
Sbjct: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
Query: 509 TQNTL 513
+T+
Sbjct: 539 FASTM 543
Score = 32.0 bits (71), Expect = 3.5
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 7/81 (8%)
Query: 890 VYIVKISASNEVGEGPFS-NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSM 948
+Y +K+ A N G+G S V L +P T P S ++K + +
Sbjct: 573 LYDIKLQAFNGNGDGNSSARCVSLCDVPLAT------PDGTVSTESKTGCSCSQGESSPL 626
Query: 949 TGIAVGVGIALTCILICVLIL 969
G+ VG+ + L ++IC+L L
Sbjct: 627 PGVVVGIHVGLAALIICLLCL 647
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 287 bits (735), Expect = 4e-77
Identities = 238/858 (27%), Positives = 399/858 (46%), Gaps = 70/858 (8%)
Query: 28 SPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMS--ENKRI 85
SP + F+ F+ EP D R V+L+C A+ E K+ W K+G ++ + R
Sbjct: 42 SPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRR 101
Query: 86 EVLSNGSLYISEVEGRRGEQSDEGFYQCLA-MNKYGAILSQKAHLALSTISAFEVQPIST 144
++L +GSL+IS V + + DEG+YQC+A + G I+S+ A L ++ + F QP +
Sbjct: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
Query: 145 EVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYR 204
V+ G A C++++ + WE NR L + DR+ LP+G+L I + ++ D G YR
Sbjct: 162 SVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-DRVIKLPSGMLVISNATEGDGGLYR 220
Query: 205 CIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264
C+ + + S E L V+P E S + P + + Q VVL C+A+G P P
Sbjct: 221 CVVESGGPPKYSDEVELKVLPDPEVIS--DLVFLKQPSPLVRVIGQDVVLPCVASGLPTP 278
Query: 265 IISWSRLDHKSIDVFNTR---VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTV-AMAT 320
I W + + +++D ++ +L G+L ISDV AG Y C A N T+ A A
Sbjct: 279 TIKWMK-NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNG---NETIEAQAE 334
Query: 321 LTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNS-K 379
LTV A P F++ P ++ + F C+ G P+P + W+KNG + + K+
Sbjct: 335 LTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN 394
Query: 380 LVINQIIPEDDAIYQCMAENSQGSILSRARLTVV-----MSEDRPSAPYNVHAETMSSSA 434
L + ++ D+ YQC+AEN G+ + A+L ++ + PSAP +V A +S+
Sbjct: 395 LQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRF 454
Query: 435 ILLAWERPLYN-SDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYI 493
I L W P + + YSV Y K EG+ E + I +L PA+ Y F +
Sbjct: 455 IKLTWRTPASDPHGDNLTYSVFYTK-EGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
Query: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPPEISLT--SRSPTDILISW-LPIPAKYRRGQVV 550
+A G+ + S + T +V L P +L + SPT I ++W P+ G++
Sbjct: 514 MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG---NGEIQ 570
Query: 551 LYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRT 610
Y+L + + Q +++ ++H Y + GLK + Y R+ A + G G S+ + RT
Sbjct: 571 NYKLYYMEKGTDKEQDVDV--SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT 628
Query: 611 PKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKEEGQQEN-GPIF 667
AP++ L LE N +I + WQ T I GYK+ Y++ ++ +
Sbjct: 629 LSDVPSAAPQN--LSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL 686
Query: 668 LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHH 727
+ L + GLD +Y+ R+ A G D + + + VP P H
Sbjct: 687 VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
Query: 728 LYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEP 787
+ +SI + W P + Y I +G +A + + + + ++ L+P
Sbjct: 747 VRPLV---TSIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQ-TIKVDYKQRYYTIENLDP 801
Query: 788 NTK-----------------YEFAV-RLHVDQ-------LSSPWSPVVYHSTLPEAPAGP 822
++ YE AV R H D +++P++PV P P
Sbjct: 802 SSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVP-----DPTPMMP 856
Query: 823 PVGVKVTLIEDDTALVSW 840
PVGV+ +++ DT ++W
Sbjct: 857 PVGVQASILSHDTIRITW 874
Score = 250 bits (638), Expect = 6e-66
Identities = 258/1028 (25%), Positives = 416/1028 (40%), Gaps = 109/1028 (10%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEG 100
F +P+ +V + +L+C+ + ++ V W +N + + R+ L +G L IS
Sbjct: 154 FTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNAT- 212
Query: 101 RRGEQSDEGFYQCLAMN----KYGAILSQKAHLALSTIS--AFEVQPISTEVHEGGVARF 154
+ D G Y+C+ + KY + K IS F QP G
Sbjct: 213 ----EGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVL 268
Query: 155 ACKISSHPPAVITWEFNRTTLPM-TMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHR 213
C S P I W N L + +R+ L G L+I DV++ D+G Y CIA +
Sbjct: 269 PCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADN-GNE 327
Query: 214 RKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDH 273
+A LTV P + P NI +V EC TG P P + W +
Sbjct: 328 TIEAQAELTVQAQ--------PEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD 379
Query: 274 KSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWP 333
I +++ NL + + G Y C A A + AP + P
Sbjct: 380 MVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLP 439
Query: 334 ESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNG-------------RIKMYNS-- 378
+ PR A V K++W H + R ++ N+
Sbjct: 440 SA---PRDVVASLVSTR----FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSH 492
Query: 379 ----KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSS 432
++ I ++P I++ MA+N GS S A L V + P N+ A S
Sbjct: 493 PGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASP 552
Query: 433 SAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFY 492
++I + WE P+ + ++ Y ++YM+ +G + E+ V + Y I+ L+ + Y+F
Sbjct: 553 TSITVTWETPVSGNGEIQNYKLYYME-KGTDKEQDVDVSSHS---YTINGLKKYTEYSFR 608
Query: 493 IVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVL 551
+VAY G + V TL DVP P+ +SL R+ I+I W P + GQ+
Sbjct: 609 VVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITG 668
Query: 552 YRLSFRLSTENS-IQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRT 610
Y++ +R ++ S + + GT L+EGL + Y R+ A T G G ++ W S T
Sbjct: 669 YKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAET 728
Query: 611 PKAT--SVKAPKSPE-LHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIF 667
++ + P+ P LH+ PL T+I V W ++GY + Y G I
Sbjct: 729 FESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIGYGI-GSPHAQTIK 786
Query: 668 LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQTVSTPGC------VSVRDRMVP 720
+D K YT+ LDP Y + L A+NN+ +G + V+ P + V +
Sbjct: 787 VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYT 846
Query: 721 PPPPPHHLYAKANTSSSIFLH------WRRPAFTAAQIIN----YTIRCNPVGLQNASLV 770
P P P + +SI H W + Q I YT+R N
Sbjct: 847 PVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTK-- 904
Query: 771 LYLQTSETHM--LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKV 828
Y + T + LV GL+PNT YEF+V + + SS WS + +T P PP V V
Sbjct: 905 -YKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTV 963
Query: 829 TLIE--DDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLV 886
E T +V+W+PP +T Y I Y++ +W + G ++ L
Sbjct: 964 VSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELT 1023
Query: 887 AGNVYIVKISASNEVGEGPFSNSVELAVLPKETSE---------------------SNQR 925
Y KI A N G GP S +V+ ++S+ S+ +
Sbjct: 1024 LDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYK 1083
Query: 926 PKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYR---SKARKSSASK 982
P + +++ S LD + I V VG+ +++ + + R S +K A+
Sbjct: 1084 PP-MSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAAC 1142
Query: 983 TAQNGTQQ 990
+ NG+ +
Sbjct: 1143 KSVNGSHK 1150
Score = 129 bits (324), Expect = 2e-29
Identities = 187/846 (22%), Positives = 332/846 (39%), Gaps = 89/846 (10%)
Query: 27 LSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM--SENKR 84
L LP S+L F+K+P + VVL C A G + W+KN + ++R
Sbjct: 237 LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSER 296
Query: 85 IEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPIST 144
+ +L+ GSL IS+V + D G Y C+A N I +Q A L + F QP +
Sbjct: 297 LVLLAGGSLEISDV-----TEDDAGTYFCIADNGNETIEAQ-AELTVQAQPEFLKQPTNI 350
Query: 145 EVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYR 204
HE F C+++ P + W N + + D + LQ+ + + D G Y+
Sbjct: 351 YAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQ 409
Query: 205 CIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKP 264
CIA ++ A L ++ E T + + P+++ SL T ++ + P
Sbjct: 410 CIAENDVGNAQA-GAQLIIL---EHAPATTGPLPSAPRDVVASLVSTRFIK-LTWRTP-- 462
Query: 265 IISWSRLDHKSIDVFNTR----------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNF 314
S D+ + VF T+ G + ++ L A VY+ R
Sbjct: 463 -ASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGS 521
Query: 315 TVAMATLTVLAPPSFVEWP-------ESLTRPRAGTARFVCQAEG---IPSPKMSWLKNG 364
+ A L V P V+ P P + T + G I + K+ +++ G
Sbjct: 522 GESSAPLRVETQPE-VQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG 580
Query: 365 RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPS-APY 423
+ + + + IN + + ++ +A N G +S + V D PS AP
Sbjct: 581 TDKEQD--VDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQ 638
Query: 424 NVHAETMSSSAILLAWE--RPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID 481
N+ E +S +I++ W+ P + ++ Y + Y KA ++ +V G + +I+
Sbjct: 639 NLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQ-LIE 697
Query: 482 DLEPASNYTFYIVAYMPMGASQMSDHVTQNTLED--VPLRPPEI--SLTSRS-PTDILIS 536
L+ + Y F + A G +D ++ T E R PE+ SL R T I++S
Sbjct: 698 GLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVS 757
Query: 537 WLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATR 596
W P + + V Y + + + + ++ Q +++ Y +E L P S Y++ + A
Sbjct: 758 W--TPPENQNIVVRGYAIGYGIGSPHA-QTIKVDYKQRYYTIENLDPSSHYVITLKAFNN 814
Query: 597 VGLG----ESSVWTSHRTPKATS---VKAPKSPELHLEP-----------LNCTTISVRW 638
VG G ES+V H + AP +P P L+ TI + W
Sbjct: 815 VGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITW 874
Query: 639 -------QQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLL 691
Q + D+ + Y + +K + L Y ++GL P Y ++
Sbjct: 875 ADNSLPKHQKITDS---RYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVM 931
Query: 692 AYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQ 751
+ T S + + + PP + +K +I ++W+ P+ +
Sbjct: 932 VTKG-----RRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGK 986
Query: 752 IINYTIRCNP---VGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSP 808
I Y I + + + + + TH +Q L +T Y F ++ + P S
Sbjct: 987 ITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQ-IQELTLDTPYYFKIQARNSKGMGPMSE 1045
Query: 809 VVYHST 814
V T
Sbjct: 1046 AVQFRT 1051
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 278 bits (712), Expect = 2e-74
Identities = 251/877 (28%), Positives = 385/877 (43%), Gaps = 81/877 (9%)
Query: 36 FSELSFVKEPQDVTVTRKDPVVLDCQAHGE--VPIKVTWLKNGAKMS--ENKRIEVLSNG 91
F+ L F+ EP D R V+LDC A + VP+ + W K+G ++ ++R + LSNG
Sbjct: 37 FTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPV-IKWKKDGIHLALGMDERKQQLSNG 95
Query: 92 SLYISEVEGRRGEQSDEGFYQCLA-MNKYGAILSQKAHLALSTISAFEVQPISTEVHEGG 150
SL I + R + DEG YQC A + G+I+S+ A +A++ F Q S G
Sbjct: 96 SLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGD 155
Query: 151 VARFACKISSHPPAVITWEFNRTTL-PMTMD-RITALPTGVLQIYDVSQRDSGNYRCIAA 208
C++ P I W+ N+ L P+ D R+ LP+G LQI + D G YRC A
Sbjct: 156 TVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSAR 215
Query: 209 TVAHRRKSMEASLTVIPAKESKSFHTPT-IIAGPQNITTSLHQTVVLECMATGNPKPIIS 267
A R EA + ++ H + P N+ + VLEC +G P P +
Sbjct: 216 NPASSRTGNEAEVRIL---SDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFT 272
Query: 268 WSRLDHKSIDVFNTR-----VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT 322
W R + +V R +LG NL+IS+V +G+Y C T N + A A LT
Sbjct: 273 WLRGE----EVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTC-VVTYKNENIS-ASAELT 326
Query: 323 VLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMY-NSKLV 381
VL PP F+ P +L + F C G P P ++W+KNG + + ++ S L
Sbjct: 327 VLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLR 386
Query: 382 INQIIPEDDAIYQCMAENSQGSILSRARL-----TVVMSEDRPSAPYNVHAETMSSSAIL 436
I ++ D+ YQC+AEN G+ + A+L + S PSAP +V +SS +
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVR 446
Query: 437 LAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAY 496
L+W P + ++V + + EG N E + + +L+P + YTF +VAY
Sbjct: 447 LSWRPPAEAKGNIQTFTVFFSR-EGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAY 505
Query: 497 MPMGASQMSDHVTQNTLEDVPLRPP--EISLTSRSPTDILISWLPIPAKYRRGQVVLYRL 554
G + S + T ++ + P + S SPT ILI+W P PA Y G V YRL
Sbjct: 506 NEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEP-PA-YANGPVQGYRL 563
Query: 555 SFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKAT 614
+ Q +E+ G + Y LEGLK + Y +R A R G G S + T
Sbjct: 564 FCTEVSTGKEQNIEVDGLS--YKLEGLKKFTEYSLRFLAYNRYGPGVS----TDDITVVT 617
Query: 615 SVKAPKSP--ELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKE---EGQQENGPIF 667
P +P + LE +N +I V W T I GYK+ +++ G+ E
Sbjct: 618 LSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMET---- 673
Query: 668 LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD-QTVSTPGCVSVRDRMVPPPPPPH 726
L+ +L Y +GL+ +Y ++ A G ++ T TP + + VP P
Sbjct: 674 LEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE-NDLDESQVPDQPSSL 732
Query: 727 HLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLE 786
H+ + N I + W P + Y I VG A V + + + + ++ LE
Sbjct: 733 HVRPQTN---CIIMSWTPPLNPNIVVRGYIIGYG-VGSPYAETV-RVDSKQRYYSIERLE 787
Query: 787 PNTKYEFAVRLH--------------VDQLSSPWSPVVYHSTLPEAPAG---------PP 823
++ Y +++ ++ P PV Y+ L + P PP
Sbjct: 788 SSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPP 847
Query: 824 VGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASR 860
VGV+ + D VSW P+ T LY R
Sbjct: 848 VGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVR 884
Score = 239 bits (609), Expect = 1e-62
Identities = 247/1028 (24%), Positives = 415/1028 (40%), Gaps = 92/1028 (8%)
Query: 39 LSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSE---NKRIEVLSNGSLYI 95
L F+ + + VT D V+L C+ GE + W KN ++ + R+ VL +G+L I
Sbjct: 140 LRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQI 199
Query: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQ------PISTEVHEG 149
S ++ D G Y+C A N + +A + + + Q P + EG
Sbjct: 200 SRLQ-----PGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEG 254
Query: 150 GVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAAT 209
A C +S +PP TW + + + + L L I +V+ DSG Y C+ T
Sbjct: 255 KDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVV-T 313
Query: 210 VAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS 269
+ S A LTV+ P + P N+ + EC +G P P ++W
Sbjct: 314 YKNENISASAELTVLVP--------PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWM 365
Query: 270 RLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSF 329
+ I +++G NL I V G Y C A T A + A PS
Sbjct: 366 KNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSS 425
Query: 330 VEWPESLTR--PRAGTARFVCQAEGIPSPKMSWLKNGRKIHS---NGRIKMYNS------ 378
P + P ++RFV + P+ ++ S + R + N+
Sbjct: 426 SVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSL 485
Query: 379 KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDR--PSAPYNVHAETMSSSAIL 436
+L + + PE ++ +A N G S + V + P N+ A + S ++IL
Sbjct: 486 QLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSIL 545
Query: 437 LAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAY 496
+ WE P Y + V Y + + + +V D Y ++ L+ + Y+ +AY
Sbjct: 546 ITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEV----DGLSYKLEGLKKFTEYSLRFLAY 601
Query: 497 MPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLS 555
G +D +T TL DVP PP+ +SL + I +SWLP P+ + G + Y++
Sbjct: 602 NRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR 661
Query: 556 FRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPK--A 613
R +T ++ L YL GL+ S Y +++A T G G S W + TP+
Sbjct: 662 HRKTTRRG-EMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
Query: 614 TSVKAPKSPE-LHLEP-LNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTK 671
+ P P LH+ P NC +S W + ++GY + Y G + +D+K
Sbjct: 721 DESQVPDQPSSLHVRPQTNCIIMS--WTPPLNPNIVVRGYIIGYGV-GSPYAETVRVDSK 777
Query: 672 DLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRM------------V 719
Y++ L+ Y + L A+NN +G ++ +T D + V
Sbjct: 778 QRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSV 837
Query: 720 P----PPPPPHHLYAKANTSSSIFLHWRRPAFT----AAQIINYTIRCNPVGLQNASLVL 771
P P PP + A A T ++ + W + +++ YT+R +A
Sbjct: 838 PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKS 897
Query: 772 YLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLI 831
TS ++ GL+PNT YEF+V + ++ SS WS + +T AP P + V
Sbjct: 898 EDTTSLSYTAT-GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 956
Query: 832 EDD--TALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGN 889
E +VSW+PP +T Y + Y K +W + G + +L
Sbjct: 957 EGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDT 1016
Query: 890 VYIVKISASNEVGEGPFSNSVELAVLPKETSE--SNQRPKRLDSADAKVYS--------- 938
+Y +I A N G GP S+ + L E + +N + + D V +
Sbjct: 1017 MYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLN 1076
Query: 939 ----GYYHLDQKSMT-----GIAVGVGIALTCILICVLILIYRSKARKSSASKTAQNGTQ 989
G H S+T + V + + + I + V++++ R+SSA + + T
Sbjct: 1077 EPPIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATH 1136
Query: 990 QLPRTSAS 997
+ S
Sbjct: 1137 SAGKRKGS 1144
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 218 bits (556), Expect = 2e-56
Identities = 239/927 (25%), Positives = 384/927 (41%), Gaps = 111/927 (11%)
Query: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM---SENKRIEVLSNGSLYISEVEGR 101
PQ V R + C A G ++TW K+ + + N RI+ L +G+L I +
Sbjct: 132 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQ---- 187
Query: 102 RGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA---FEVQPISTEVHEGGVARFACKI 158
E+SD+G Y+C+A N G S A+L + F + P + E+ GG C
Sbjct: 188 -SEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVA 246
Query: 159 SSHPPAVITWEFNRTTLPMTMDRITALPTG--VLQIYDVSQRDSGNYRCIAATVAHRRKS 216
P + W L D +P G VL++ DV R S NY C+A + ++
Sbjct: 247 VGSPMPYVKWMLGAEDLTPEDD----MPIGRNVLELNDV--RQSANYTCVAMSTLGVIEA 300
Query: 217 MEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK-- 274
+ A +TV K+ P G +T S ++ L +GNP+P+ S+ + HK
Sbjct: 301 I-AQITV------KALPKPP---GTPVVTESTATSITLT-WDSGNPEPV-SYYIIQHKPK 348
Query: 275 -------SID-VFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAP 326
ID V TR G SD + V P T AP
Sbjct: 349 NSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAP 408
Query: 327 PS-----------FVEWPESLTRPRAGTARFVCQAEGIPSPKMS-WLKNGRKIHSNGRIK 374
V+W E P + P+ ++ W+K+
Sbjct: 409 RDVQARMLSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHN---------- 457
Query: 375 MYNSKLV-INQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSS 433
+ +S++ I ++P+ + +A S G + + V+ P P N AE S +
Sbjct: 458 VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET 517
Query: 434 AILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYI 493
+ILL+W P SD + Y + Y +G + EE ++ I T+ Y + L+P S Y F +
Sbjct: 518 SILLSWTPP--RSDTIANYELVYK--DGEHGEEQRITIEPGTS-YRLQGLKPNSLYYFRL 572
Query: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLY 552
A P G + ++ T++ P PP+ IS TS S T IL+SW P P + + G + Y
Sbjct: 573 AARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEY 632
Query: 553 RLSFRL---STENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHR 609
+ + + ++L +P T +YLLE L+ + Y + +TA T VG G S+ R
Sbjct: 633 SIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR 692
Query: 610 TPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYKLYY--KEEGQQENGP 665
T + P+ E +E +N T++ V W+ V + I+GY+++Y E G+ + P
Sbjct: 693 TNEDVPSGPPRKVE--VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQP 750
Query: 666 I------------FLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQTVSTPGCV 712
+ F DT + +SGL P Y + + AY DG ++ + VST G V
Sbjct: 751 MLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAV 810
Query: 713 SVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLY 772
+ R+V + + NT+ + W P T + Y ++ ++ + L
Sbjct: 811 PGKPRLVIN-------HTQMNTA---LIQWHPPVDTFGPLQGYRLKFGRKDMEPLT-TLE 859
Query: 773 LQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLP-EAPAGPPVGVKVTLI 831
E H + Y F RL +V ++P E P G P +
Sbjct: 860 FSEKEDHFTATDIHKGASYVF--RLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT 917
Query: 832 EDDTALVSWKPPDGPET--VVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGN 889
+ +SW+PP E ++T+YT+LY + Q++ A T L L
Sbjct: 918 TSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI--VPADTTMTLTGLKPDT 975
Query: 890 VYIVKISASNEVGEGPFSNSVELAVLP 916
Y VK+ A G GP+S SV+ LP
Sbjct: 976 TYDVKVRAHTSKGPGPYSPSVQFRTLP 1002
Score = 214 bits (546), Expect = 3e-55
Identities = 232/923 (25%), Positives = 378/923 (40%), Gaps = 74/923 (8%)
Query: 20 ALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM 79
A LLLLLL+ + F + P D T CQA G+ K+ W K G K+
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 80 SENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALST---- 133
S N+R EV+ +GS + ++ R + DE Y+C+A N G I L
Sbjct: 65 S-NQRFEVIEFDDGSGSVLRIQPLRTPR-DEAIYECVASNNVGEISVSTRLTVLREDQIP 122
Query: 134 --ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPTGV 189
++ P V A C S +P ITW +F RI L +G
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGA 182
Query: 190 LQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLH 249
LQI + D G Y C+A A R S A+L V + F P P N
Sbjct: 183 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIP-----PTNHEIMPG 237
Query: 250 QTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTP 309
+V + C+A G+P P + W L + + + +G L ++DVR + Y C A +
Sbjct: 238 GSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELNDVR--QSANYTCVAMS- 293
Query: 310 GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS 369
T A+A +TV A P P + T+ + G P P ++ + +S
Sbjct: 294 -TLGVIEAIAQITVKALPKPPGTP--VVTESTATSITLTWDSGNPEPVSYYIIQHKPKNS 350
Query: 370 NGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRP-SAPYN 424
K + ++ + + P D ++ +A N+ G + SE P SAP +
Sbjct: 351 EELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRD 410
Query: 425 VHAETMSSSAILLAWERPLYNSDKVIAYSVHYM--KAEGLNNEEYQVVIGNDTTHYIIDD 482
V A +SS+ IL+ W+ P + ++ Y V+Y + +NN V + T I +
Sbjct: 411 VQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT--TIGN 468
Query: 483 LEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPA 542
L P Y+ ++A+ +G +S + T VP +P S T IL+SW P
Sbjct: 469 LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTP--- 525
Query: 543 KYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRITAATRVGLGE 601
R + Y L ++ Q + + PGT+ Y L+GLKP+S+Y R+ A + GLG
Sbjct: 526 -PRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARSPQGLGA 582
Query: 602 SSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQD--VEDTAAIQGYKLYYKEEG 659
S+ S RT ++ P+ ++ + T+I V WQ + I Y + Y
Sbjct: 583 STAEISARTMQSKPSAPPQ--DISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 640
Query: 660 QQENGP---IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRD 716
+++ P + + + Y L L+ +Y + + A+ ++ G ++ V +R
Sbjct: 641 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS-------VLIRT 693
Query: 717 RMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTIRC------NPVGLQNAS 768
P PP + +A S+S+ + WR P QI Y + P G
Sbjct: 694 NEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLK 753
Query: 769 LVL-------YLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAG 821
V+ + T+E M++ GL+P T Y V + + S ST P
Sbjct: 754 DVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK 813
Query: 822 PPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMAL 881
P + + T + +TAL+ W PP + Y + + + + +E T
Sbjct: 814 PRLVINHT--QMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTAT- 870
Query: 882 LENLVAGNVYIVKISASNEVGEG 904
++ G Y+ ++SA N+VG G
Sbjct: 871 --DIHKGASYVFRLSARNKVGFG 891
Score = 32.3 bits (72), Expect = 2.7
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 424 NVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDL 483
N H + + +++LL+WE P N + + + + Y +G EE + T +I +L
Sbjct: 1010 NFHVKAVMKTSVLLSWEIP-ENYNSAMPFKILY--DDGKMVEE----VDGRATQKLIVNL 1062
Query: 484 EPASNYTFYIVAYMPMGASQMSDHVTQNTLEDV 516
+P +Y+F ++ A + VT T DV
Sbjct: 1063 KPEKSYSF-VLTNRGNSAGGLQHRVTAKTAPDV 1094
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 217 bits (552), Expect = 6e-56
Identities = 237/928 (25%), Positives = 387/928 (41%), Gaps = 109/928 (11%)
Query: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM---SENKRIEVLSNGSLYISEVEG- 100
PQ V R + C A G ++TW K+ + + N RI+ L + S+ + + G
Sbjct: 132 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGA 191
Query: 101 ---RRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA-------FEVQPISTEVHEGG 150
+ E+SD+G Y+C+A N G S A+L + + F + P + E+ GG
Sbjct: 192 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 251
Query: 151 VARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG--VLQIYDVSQRDSGNYRCIAA 208
C P + W L D +P G VL++ DV R S NY C+A
Sbjct: 252 SVNITCVAVGSPMPYVKWMLGAEDLTPEDD----MPIGRNVLELNDV--RQSANYTCVAM 305
Query: 209 TVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISW 268
+ +++ A +TV K+ P G +T S ++ L +GNP+P+ S+
Sbjct: 306 STLGVIEAI-AQITV------KALPKPP---GTPVVTESTATSITLT-WDSGNPEPV-SY 353
Query: 269 SRLDHK---------SID-VFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAM 318
+ HK ID V TR G SD + V P T
Sbjct: 354 YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS 413
Query: 319 ATLTVLAPPS-----------FVEWPESLTRPRAGTARFVCQAEGIPSPKMS-WLKNGRK 366
AP V+W E P + P+ ++ W+K+
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHN-- 470
Query: 367 IHSNGRIKMYNSKLV-INQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNV 425
+ +S++ I ++P+ + +A S G + + V+ P P N
Sbjct: 471 --------VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNF 522
Query: 426 HAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEP 485
AE S ++ILL+W P SD + Y + Y +G + EE ++ I T+ Y + L+P
Sbjct: 523 KAEPESETSILLSWTPP--RSDTIANYELVYK--DGEHGEEQRITIEPGTS-YRLQGLKP 577
Query: 486 ASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKY 544
S Y F + A P G + ++ T++ P PP+ IS TS S T IL+SW P P +
Sbjct: 578 NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK 637
Query: 545 RRGQVVLYRLSFRL---STENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGE 601
+ G + Y + + + ++L +P T +YLLE L+ + Y + +TA T VG G
Sbjct: 638 QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGP 697
Query: 602 SSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYKLYY--KE 657
S+ RT + P+ E +E +N T++ V W+ V + I+GY+++Y E
Sbjct: 698 ESLSVLIRTNEDVPSGPPRKVE--VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRME 755
Query: 658 EGQQENGP-----IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQTVSTPGC 711
G+ + P + D +D++ +SGL P Y + + AY DG ++ + VST G
Sbjct: 756 NGEPKGQPMLKDVMLADAQDMI--ISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA 813
Query: 712 VSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVL 771
V + R+V + + NT+ + W P T + Y ++ ++ + L
Sbjct: 814 VPGKPRLVIN-------HTQMNTA---LIQWHPPVDTFGPLQGYRLKFGRKDMEPLT-TL 862
Query: 772 YLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLP-EAPAGPPVGVKVTL 830
E H + Y F RL +V ++P E P G P +
Sbjct: 863 EFSEKEDHFTATDIHKGASYVF--RLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEG 920
Query: 831 IEDDTALVSWKPPDGPET--VVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAG 888
+ +SW+PP E ++T+YT+LY + Q++ A T L L
Sbjct: 921 TTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI--VPADTTMTLTGLKPD 978
Query: 889 NVYIVKISASNEVGEGPFSNSVELAVLP 916
Y VK+ A G GP+S SV+ LP
Sbjct: 979 TTYDVKVRAHTSKGPGPYSPSVQFRTLP 1006
Score = 207 bits (526), Expect = 6e-53
Identities = 230/925 (24%), Positives = 376/925 (40%), Gaps = 74/925 (8%)
Query: 20 ALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM 79
A LLLLLL+ + F + P D T CQA G+ K+ W K G K+
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 80 SENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALST---- 133
S N+R EV+ +GS + ++ R + DE Y+C+A N G I L
Sbjct: 65 S-NQRFEVIEFDDGSGSVLRIQPLRTPR-DEAIYECVASNNVGEISVSTRLTVLREDQIP 122
Query: 134 --ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPT-- 187
++ P V A C S +P ITW +F RI L +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSES 182
Query: 188 -------GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
G LQI + D G Y C+A A R S A+L V +E + P
Sbjct: 183 IGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRV-PPRFSIP 241
Query: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
P N +V + C+A G+P P + W L + + + +G L ++DVR +
Sbjct: 242 PTNHEIMPGGSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELNDVR--QSA 298
Query: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Y C A + T A+A +TV A P P + T+ + G P P +
Sbjct: 299 NYTCVAMS--TLGVIEAIAQITVKALPKPPGTP--VVTESTATSITLTWDSGNPEPVSYY 354
Query: 361 LKNGRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSE 416
+ + +S K + ++ + + P D ++ +A N+ G + SE
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 417 DRP-SAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYM--KAEGLNNEEYQVVIGN 473
P SAP +V A +SS+ IL+ W+ P + ++ Y V+Y + +NN V +
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADS 474
Query: 474 DTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDI 533
T I +L P Y+ ++A+ +G +S + T VP +P S T I
Sbjct: 475 QIT--TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 534 LISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRIT 592
L+SW P R + Y L ++ Q + + PGT+ Y L+GLKP+S+Y R+
Sbjct: 533 LLSWTP----PRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLA 586
Query: 593 AATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQD--VEDTAAIQG 650
A + GLG S+ S RT ++ P+ ++ + T+I V WQ + I
Sbjct: 587 ARSPQGLGASTAEISARTMQSKPSAPPQ--DISCTSPSSTSILVSWQPPPVEKQNGIITE 644
Query: 651 YKLYYKEEGQQENGP---IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVS 707
Y + Y +++ P + + + Y L L+ +Y + + A+ ++ G ++
Sbjct: 645 YSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS--- 701
Query: 708 TPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTIRC------ 759
V +R P PP + +A S+S+ + WR P QI Y +
Sbjct: 702 ----VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENG 757
Query: 760 NPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAP 819
P G V+ + M++ GL+P T Y V + + S ST P
Sbjct: 758 EPKGQPMLKDVMLADAQD--MIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP 815
Query: 820 AGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITM 879
P + + T + +TAL+ W PP + Y + + + + +E T
Sbjct: 816 GKPRLVINHT--QMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA 873
Query: 880 ALLENLVAGNVYIVKISASNEVGEG 904
++ G Y+ ++SA N+VG G
Sbjct: 874 T---DIHKGASYVFRLSARNKVGFG 895
Score = 32.3 bits (72), Expect = 2.7
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 424 NVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDL 483
N H + + +++LL+WE P N + + + + Y +G EE + T +I +L
Sbjct: 1014 NFHVKAVMKTSVLLSWEIP-ENYNSAMPFKILY--DDGKMVEE----VDGRATQKLIVNL 1066
Query: 484 EPASNYTFYIVAYMPMGASQMSDHVTQNTLEDV 516
+P +Y+F ++ A + VT T DV
Sbjct: 1067 KPEKSYSF-VLTNRGNSAGGLQHRVTAKTAPDV 1098
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 215 bits (547), Expect = 2e-55
Identities = 238/935 (25%), Positives = 386/935 (41%), Gaps = 114/935 (12%)
Query: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM---SENKRIEVLSNGSLYISEVEG- 100
PQ V R + C A G ++TW K+ + + N RI+ L + S+ + + G
Sbjct: 132 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGA 191
Query: 101 ---RRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA-------FEVQPISTEVHEGG 150
+ E+SD+G Y+C+A N G S A+L + + F + P + E+ GG
Sbjct: 192 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 251
Query: 151 VARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG--VLQIYDVSQRDSGNYRCIAA 208
C P + W L D +P G VL++ DV R S NY C+A
Sbjct: 252 SVNITCVAVGSPMPYVKWMLGAEDLTPEDD----MPIGRNVLELNDV--RQSANYTCVAM 305
Query: 209 TVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISW 268
+ +++ A +TV K+ P G +T S ++ L +GNP+P+ S+
Sbjct: 306 STLGVIEAI-AQITV------KALPKPP---GTPVVTESTATSITLT-WDSGNPEPV-SY 353
Query: 269 SRLDHK---------SID-VFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAM 318
+ HK ID V TR G SD + V P T
Sbjct: 354 YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS 413
Query: 319 ATLTVLAPPS-----------FVEWPESLTRPRAGTARFVCQAEGIPSPKMS-WLKNGRK 366
AP V+W E P + P+ ++ W+K+
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEP-EEPNGQIQGYRVYYTMDPTQHVNNWMKHN-- 470
Query: 367 IHSNGRIKMYNSKLV-INQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNV 425
+ +S++ I ++P+ + +A S G + + V+ P P N
Sbjct: 471 --------VADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNF 522
Query: 426 HAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEP 485
AE S ++ILL+W P SD + Y + Y +G + EE ++ I T+ Y + L+P
Sbjct: 523 KAEPESETSILLSWTPP--RSDTIANYELVYK--DGEHGEEQRITIEPGTS-YRLQGLKP 577
Query: 486 ASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKY 544
S Y F + A P G + ++ T++ P PP+ IS TS S T IL+SW P P +
Sbjct: 578 NSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEK 637
Query: 545 RRGQVVLYRLSFRL---STENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGE 601
+ G + Y + + + ++L +P T +YLLE L+ + Y + +TA T VG G
Sbjct: 638 QNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGP 697
Query: 602 SSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYKLYY--KE 657
S+ RT + P+ E +E +N T++ V W+ V + I+GY+++Y E
Sbjct: 698 ESLSVLIRTNEDVPSGPPRKVE--VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRME 755
Query: 658 EGQQENGPI------------FLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQ 704
G+ + P+ F DT + +SGL P Y + + AY DG ++ +
Sbjct: 756 NGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPK 815
Query: 705 TVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGL 764
VST G V + R+V + + NT+ + W P T + Y ++ +
Sbjct: 816 LVSTTGAVPGKPRLVIN-------HTQMNTA---LIQWHPPVDTFGPLQGYRLKFGRKDM 865
Query: 765 QNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLP-EAPAGPP 823
+ + L E H + Y F RL +V ++P E P G P
Sbjct: 866 EPLT-TLEFSEKEDHFTATDIHKGASYVF--RLSARNKVGFGEEMVKEISIPEEVPTGFP 922
Query: 824 VGVKVTLIEDDTALVSWKPPDGPET--VVTRYTILYASRKAWIAGEWQVLHREGAITMAL 881
+ + +SW+PP E ++T+YT+LY + Q++ A T
Sbjct: 923 QNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI--VPADTTMT 980
Query: 882 LENLVAGNVYIVKISASNEVGEGPFSNSVELAVLP 916
L L Y VK+ A G GP+S SV+ LP
Sbjct: 981 LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP 1015
Score = 207 bits (528), Expect = 4e-53
Identities = 232/932 (24%), Positives = 379/932 (40%), Gaps = 79/932 (8%)
Query: 20 ALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM 79
A LLLLLL+ + F + P D T CQA G+ K+ W K G K+
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 80 SENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALST---- 133
S N+R EV+ +GS + ++ R + DE Y+C+A N G I L
Sbjct: 65 S-NQRFEVIEFDDGSGSVLRIQPLRTPR-DEAIYECVASNNVGEISVSTRLTVLREDQIP 122
Query: 134 --ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPT-- 187
++ P V A C S +P ITW +F RI L +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSES 182
Query: 188 -------GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
G LQI + D G Y C+A A R S A+L V +E + P
Sbjct: 183 IGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRV-PPRFSIP 241
Query: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
P N +V + C+A G+P P + W L + + + +G L ++DVR +
Sbjct: 242 PTNHEIMPGGSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELNDVR--QSA 298
Query: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Y C A + T A+A +TV A P P + T+ + G P P +
Sbjct: 299 NYTCVAMS--TLGVIEAIAQITVKALPKPPGTP--VVTESTATSITLTWDSGNPEPVSYY 354
Query: 361 LKNGRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSE 416
+ + +S K + ++ + + P D ++ +A N+ G + SE
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 417 DRP-SAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYM--KAEGLNNEEYQVVIGN 473
P SAP +V A +SS+ IL+ W+ P + ++ Y V+Y + +NN V +
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADS 474
Query: 474 DTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDI 533
T I +L P Y+ ++A+ +G +S + T VP +P S T I
Sbjct: 475 QIT--TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 534 LISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRIT 592
L+SW P R + Y L ++ Q + + PGT+ Y L+GLKP+S+Y R+
Sbjct: 533 LLSWTP----PRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLA 586
Query: 593 AATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQD--VEDTAAIQG 650
A + GLG S+ S RT ++ P+ ++ + T+I V WQ + I
Sbjct: 587 ARSPQGLGASTAEISARTMQSKPSAPPQ--DISCTSPSSTSILVSWQPPPVEKQNGIITE 644
Query: 651 YKLYYKEEGQQENGP---IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVS 707
Y + Y +++ P + + + Y L L+ +Y + + A+ ++ G ++
Sbjct: 645 YSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS--- 701
Query: 708 TPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTIRC------ 759
V +R P PP + +A S+S+ + WR P QI Y +
Sbjct: 702 ----VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENG 757
Query: 760 NPVGLQNASLVL-------YLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH 812
P G V+ + T+E M++ GL+P T Y V + + S
Sbjct: 758 EPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLV 817
Query: 813 STLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLH 872
ST P P + + T + +TAL+ W PP + Y + + + +
Sbjct: 818 STTGAVPGKPRLVINHT--QMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSE 875
Query: 873 REGAITMALLENLVAGNVYIVKISASNEVGEG 904
+E T ++ G Y+ ++SA N+VG G
Sbjct: 876 KEDHFTAT---DIHKGASYVFRLSARNKVGFG 904
Score = 32.3 bits (72), Expect = 2.7
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 424 NVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDL 483
N H + + +++LL+WE P N + + + + Y +G EE + T +I +L
Sbjct: 1023 NFHVKAVMKTSVLLSWEIP-ENYNSAMPFKILY--DDGKMVEE----VDGRATQKLIVNL 1075
Query: 484 EPASNYTFYIVAYMPMGASQMSDHVTQNTLEDV 516
+P +Y+F ++ A + VT T DV
Sbjct: 1076 KPEKSYSF-VLTNRGNSAGGLQHRVTAKTAPDV 1107
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 192 bits (489), Expect = 1e-48
Identities = 238/948 (25%), Positives = 382/948 (40%), Gaps = 128/948 (13%)
Query: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM---SENKRIEVLSNGSLYISEVEGR 101
PQ V R + C A G ++TW K+ + + N RI+ L +G+L I
Sbjct: 141 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIES---- 196
Query: 102 RGEQSDEGFYQCLAMNKYGAILSQKAHLALST---ISAFEVQPISTEVHEGGVARFACKI 158
E++D+G Y+C+A N G S A+L + F + P+S E+ GG C
Sbjct: 197 -SEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVA 255
Query: 159 SSHPPAVITWEFNRTTLPMTMDRITALPTG--VLQIYDVSQRDSGNYRCIAATVAHRRKS 216
P + W L D +P G VL++ DV +DS NY C+A +
Sbjct: 256 VGSPMPYVKWMQGAEDLTPEDD----MPVGRNVLELTDV--KDSANYTCVAMSSLG---V 306
Query: 217 MEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSI 276
+EA + K+ TP + +N TS+ T +GNP P+ S+ +++KS
Sbjct: 307 IEAVAQITVKSLPKAPGTPMVT---ENTATSITIT-----WDSGNPDPV-SYYVIEYKSK 357
Query: 277 ----------DVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAP 326
D+ TR G S+ ++V + G + ++ T T
Sbjct: 358 SQDGPYQIKEDITTTRYSIGGLSPNSEYE-----IWVSAVNSIGQGPPSESVVTRTGEQA 412
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKI-------HSNGRIKMYNSK 379
P+ P ++ + Q E P + L G ++ H G + +N
Sbjct: 413 PASA--PRNVQARMLSATTMIVQWEEPVEP--NGLIRGYRVYYTMEPEHPVGNWQKHNVD 468
Query: 380 ----LVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAI 435
+ ++ ++ + +A S G + V + P P N+ AE S ++I
Sbjct: 469 DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 528
Query: 436 LLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVA 495
L+W P + +I Y + + EG + E + TT Y+++DL+P + Y F + A
Sbjct: 529 TLSWSPP--RQESIIKYELLFR--EGDHGREVGRTF-DPTTSYVVEDLKPNTEYAFRLAA 583
Query: 496 YMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYRL 554
P G + V Q TL+ P PP+ + S T IL+SW P P + G +V Y +
Sbjct: 584 RSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSV 643
Query: 555 SFR-LSTENSI--QVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTP 611
+R L +E+ +V +P TT + LLE L+ + Y + A T VG G S RT
Sbjct: 644 RYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTD 703
Query: 612 KATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYKLYY-KEEGQQENGP--- 665
+ P+ E E LN T I V W+ I+GY+++Y + EG + GP
Sbjct: 704 EDVPSAPPRKVEA--EALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRI 761
Query: 666 ---IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD-QTVSTPGCVSVRDRMVPP 721
+ D ++++ T L P Y + + AY DG ++ + V T G V R +
Sbjct: 762 KDVMLADAQEMVIT--NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ 819
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAA-QIINYTIRCNPVGLQNASLVLYLQ--TSET 778
P L A+ W PA TA Q++ Y ++ G ++++ + L+ SE
Sbjct: 820 QTPEGSLLAR----------WEPPAGTAEDQVLGYRLQ---FGREDSTPLATLEFPPSED 866
Query: 779 HMLVQGLEPNTKYEFAVRLH---------VDQLSSPWSPVVYHSTLPEAPAGPPVGVKVT 829
G+ Y F + + LS P H + EA G
Sbjct: 867 RYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAG---- 922
Query: 830 LIEDDTALVSWKPPDGPET--VVTRYTILYASRKAWIAG-----EWQVLHREGAITMALL 882
T L+ W PP E + +YT+ A R+A G E GA L
Sbjct: 923 -----TVLLRWLPPVPAERNGAIVKYTV--AVREAGALGPARETELPAAAEPGAENALTL 975
Query: 883 ENLVAGNVYIVKISASNEVGEGPFSNSVEL-AVLPKETSESNQRPKRL 929
+ L Y +++ A G GPFS V L + S N + K +
Sbjct: 976 QGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMI 1023
Score = 186 bits (472), Expect = 1e-46
Identities = 221/930 (23%), Positives = 380/930 (40%), Gaps = 86/930 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLS--NGSLYISEV 98
F+KEP+D CQA G+ +VTW K G K++ ++R E + + + +
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN-SQRFETIEFDESAGAVLRI 93
Query: 99 EGRRGEQSDEGFYQCLAMNKYGAILSQKAHLAL------STISAFEVQPISTEVHEGGVA 152
+ R + DE Y+C+A N G I L S ++ P V A
Sbjct: 94 QPLRTPR-DENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 153 RFACKISSHPPAVITW--EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATV 210
C S +P ITW +F + RI L +G LQI + D G Y C+A
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNS 212
Query: 211 AHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSR 270
A R S A+L V + + F +I+ P + V + C+A G+P P + W +
Sbjct: 213 AGVRYSSPANLYVRVRRVAPRF---SIL--PMSHEIMPGGNVNITCVAVGSPMPYVKWMQ 267
Query: 271 LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFV 330
+ + + +G L ++DV+ + Y C A + + A+A +TV + P
Sbjct: 268 -GAEDLTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQITVKSLPKAP 322
Query: 331 EWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNG--RIK--MYNSKLVINQII 386
P + T+ + G P P ++ + +G +IK + ++ I +
Sbjct: 323 GTP--MVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLS 380
Query: 387 PEDDAIYQCMAENSQGSILSRARLTVVMSEDRP-SAPYNVHAETMSSSAILLAWERPLYN 445
P + A NS G + E P SAP NV A +S++ +++ WE P+
Sbjct: 381 PNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEP 440
Query: 446 SDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPA-------SNYTFYIVAYMP 498
+ + Y V+Y E + +GN H + D L YT ++A+
Sbjct: 441 NGLIRGYRVYY-------TMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTS 493
Query: 499 MGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRL 558
+G +SD + T + VP +P + +RS T I +SW P R+ ++ Y L FR
Sbjct: 494 VGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP----PRQESIIKYELLFR- 548
Query: 559 STENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKA 618
++ +V T Y++E LKP++ Y R+ A + GLG + RT ++
Sbjct: 549 EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAP 608
Query: 619 PKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKEEGQQENGP-----IFLDTK 671
P+ ++ + T I V W+ +T A+ GY + Y+ G ++ P I T
Sbjct: 609 PQ--DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTT 666
Query: 672 DLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAK 731
+L L L+ +Y + +A+ + G ++ V VR P PP + A+
Sbjct: 667 QIL--LEALEKWTQYRITTVAHTEVGPGPESSPVV-------VRTDEDVPSAPPRKVEAE 717
Query: 732 ANTSSSIFLHWRRPA--FTAAQIINYTIR------CNPVGLQNASLVLYLQTSETHMLVQ 783
A +++I + WR PA QI Y + G V+ E M++
Sbjct: 718 ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQE--MVIT 775
Query: 784 GLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPP 843
L+P T Y V + + S T P + V+ T + + L W+PP
Sbjct: 776 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT--PEGSLLARWEPP 833
Query: 844 DG-PETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVG 902
G E V Y + + + + E T + + G Y+ +++A + G
Sbjct: 834 AGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTAS---GVHKGATYVFRLAARSRGG 890
Query: 903 EGPFSNSVELAVLPKETSESNQRPKRLDSA 932
G + E+ +P++T + P+ L++A
Sbjct: 891 LG--EEAAEVLSIPEDTPRGH--PQILEAA 916
Score = 92.4 bits (228), Expect = 2e-18
Identities = 118/470 (25%), Positives = 178/470 (37%), Gaps = 42/470 (8%)
Query: 410 LTVVMSEDRPSAP-YNVHAETMSSSAILLAWERPLYNSD--KVIAYSVHYMKAEGLNNE- 465
+ V ED PSAP V AE ++++AI + W P ++ Y VHY++ EG
Sbjct: 698 VVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARG 757
Query: 466 --EYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEI 523
+ V+ D +I +L+P + Y+ + AY G S T V L P +
Sbjct: 758 PPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAV-LGRPTL 816
Query: 524 SLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKP 583
S+ +L W P PA QV+ YRL F + LE P + Y G+
Sbjct: 817 SVQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHK 875
Query: 584 DSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV- 642
+ Y+ R+ A +R GLGE + P+ T P+ E + T+ +RW V
Sbjct: 876 GATYVFRLAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEA-AGNASAGTVLLRWLPPVP 933
Query: 643 -EDTAAIQGYKLYYKEEG------QQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNN 695
E AI Y + +E G + E + TL GL P Y +++ A+
Sbjct: 934 AERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTR 993
Query: 696 IDDGYQADQTVSTPGCVSVRDR-MVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIIN 754
G P VR R + P + K +S+ L W P N
Sbjct: 994 RGPG---------PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPD-------N 1037
Query: 755 YTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHST 814
Y P +Q L L + T L+ L+P+T Y F + L V +
Sbjct: 1038 YN-SPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTA 1096
Query: 815 LPEAPAGPPVGVKVTLIEDDTALVSWKPPDG--PETVVTRYTILYASRKA 862
P V K D + PDG P V + + ++ RK+
Sbjct: 1097 FNLLNGKPSVAPK----PDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKS 1142
Score = 71.6 bits (174), Expect = 4e-12
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 14/131 (10%)
Query: 309 PGTRNFTVAMATLTVLA--------PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
PG + M L VL PP F++ P+ G A FVCQA G P P+++W
Sbjct: 7 PGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTW 66
Query: 361 LKNGRKIHSN--GRIKMYNSKLVINQI----IPEDDAIYQCMAENSQGSILSRARLTVVM 414
K G+K++S I+ S + +I P D+ +Y+C+A+NS G I A+LTV+
Sbjct: 67 NKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLR 126
Query: 415 SEDRPSAPYNV 425
+ PS N+
Sbjct: 127 EDQLPSGFPNI 137
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 191 bits (486), Expect = 3e-48
Identities = 219/932 (23%), Positives = 373/932 (40%), Gaps = 68/932 (7%)
Query: 1 MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC 60
MAP P + P L+ AL++L L++ G S+ F+K P+D T C
Sbjct: 1 MAPEPAPGRTMVP---LVPALVMLGLVAGAHGD---SKPVFIKVPEDQTGLSGGVASFVC 54
Query: 61 QAHGEVPIKVTWLKNGAKMSENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNK 118
QA GE ++TW+K G K+S ++R EV+ +G+ + ++ R Q DE Y+C A N
Sbjct: 55 QATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVLRIQPLR-VQRDEAIYECTATNS 112
Query: 119 YGAILSQKAHLALST------ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EF 170
G I + L + ++ P V + A C +P I+W +F
Sbjct: 113 LGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDF 172
Query: 171 NRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESK 230
+ RI L +G LQI + D G Y C+A A R S A+L V + +
Sbjct: 173 LPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAP 232
Query: 231 SFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLM 290
F P P + +V L C+A G P P + W + + + + +G L
Sbjct: 233 RFSIP-----PSSQEVMPGGSVNLTCVAVGAPMPYVKW-MMGAEELTKEDEMPVGRNVLE 286
Query: 291 ISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQA 350
+S+V + Y C A + A T+ L P + + T+ +
Sbjct: 287 LSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPI----DLVVTETTATSVTLTWD 340
Query: 351 EGIPSPKMSWLKNGRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILS 406
G P + R + G + + ++ I + P + ++ +A NS G
Sbjct: 341 SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPP 400
Query: 407 RARLTVVMSEDRPSA-PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNE 465
+ E PS+ P V A +S+S +L+ WE P + V Y V+Y
Sbjct: 401 SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPN 460
Query: 466 EYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISL 525
+ + + L P Y+ ++A+ +G S + T + VP +P +
Sbjct: 461 AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA 520
Query: 526 TSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDS 585
S T I +SWL P + ++++Y L + + + Q T Y LE LKPD+
Sbjct: 521 EVESDTRIQLSWLLPPQE----RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDT 576
Query: 586 VYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT 645
+Y ++ A + +G+G + RT ++T P+ ++ + TT+ V W D+
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQ--KVMCVSMGSTTVRVSWVPPPADS 634
Query: 646 --AAIQGYKLYYKEEGQQENGPIFLD---TKDLLYTLSGLDPRRKYHVRLLAYNNIDDGY 700
I Y + Y+ ++ G +D + + L GL+ +Y V + A+ ++ G
Sbjct: 635 RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGP 694
Query: 701 QADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTI- 757
+ S+P V VR P PP + + S+++ ++W+ P + QI Y +
Sbjct: 695 E-----SSP--VLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVT 747
Query: 758 -----RCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH 812
P GL V+ + ET + GL P T Y V + + S
Sbjct: 748 YVRLENGEPRGLPIIQDVMLAEAQET--TISGLTPETTYSVTVAAYTTKGDGARSKPKIV 805
Query: 813 STLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLH 872
+T P P + + T + +TAL+ W PP + Y + Y
Sbjct: 806 TTTGAVPGRPTMMISTTAM--NTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK 863
Query: 873 REGAITMALLENLVAGNVYIVKISASNEVGEG 904
+ T+ L G YI +++A N G G
Sbjct: 864 DDQHFTVT---GLHKGTTYIFRLAAKNRAGLG 892
Score = 140 bits (352), Expect = 9e-33
Identities = 132/515 (25%), Positives = 213/515 (41%), Gaps = 39/515 (7%)
Query: 419 PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478
P+ P + AE S + I L+W P +++I Y + Y AE + ++ V + T+ Y
Sbjct: 512 PAQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAE--DEDQQHKVTFDPTSSY 567
Query: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISW 537
++DL+P + Y F + A MG + + T + P PP+ + S T + +SW
Sbjct: 568 TLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSW 627
Query: 538 LPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYL---LEGLKPDSVYLVRITAA 594
+P PA R G + Y +++ + G + E+ L GL+ + Y V + A
Sbjct: 628 VPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH 687
Query: 595 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYK 652
T VG G S RT + P+ E+ EPLN T + V W+ V + I+GY+
Sbjct: 688 TDVGPGPESSPVLVRTDEDVPSGPPRKVEV--EPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 653 LYYK--EEGQQENGPIFLDT---KDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD-QTV 706
+ Y E G+ PI D + T+SGL P Y V + AY DG ++ + V
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIV 805
Query: 707 STPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQN 766
+T G V R M+ ++ L W P +++ Y ++
Sbjct: 806 TTTGAVPGRPTMM----------ISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEAR 855
Query: 767 ASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPE-APAGPPVG 825
+ + + + + H V GL T Y F RL + PE P+G P
Sbjct: 856 PNTIDFGKDDQ-HFTVTGLHKGTTYIF--RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQN 912
Query: 826 VKVTLIEDDTALVSWKPPDGPETV--VTRYTILYASRKAWIAGEWQVLHREGAITMALLE 883
+ VT + T ++W PP E + YT+++ Q L T L
Sbjct: 913 LHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD-----INSQQELQNITTDTRFTLT 967
Query: 884 NLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKE 918
L Y +K+ A G GP S S++ +P E
Sbjct: 968 GLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE 1002
Score = 127 bits (318), Expect = 8e-29
Identities = 126/506 (24%), Positives = 217/506 (42%), Gaps = 39/506 (7%)
Query: 378 SKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAP-YNVHAETMSSSAIL 436
S + + P+ +Q A + G + + ++ PSAP V +M S+ +
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
Query: 437 LAWERPLYNSDK--VIAYSVHYMKAEGLNNEEYQVV-IGNDTTHYIIDDLEPASNYTFYI 493
++W P +S + YSV Y +G + + V I + + + + LE + Y ++
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWV 684
Query: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISW-LPIPAKYRRGQVVL 551
A+ +G S V T EDVP PP ++ + + T + + W LP+P+K + GQ+
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSK-QHGQIRG 743
Query: 552 YRLSFRLSTENS-------IQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSV 604
Y++++ + EN IQ + L E + GL P++ Y V + A T G G S
Sbjct: 744 YQVTY-VRLENGEPRGLPIIQDVML-AEAQETTISGLTPETTYSVTVAAYTTKGDGARS- 800
Query: 605 WTSHRTPK--ATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQE 662
PK T+ P P + + T ++W E + GY+L Y +
Sbjct: 801 -----KPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEAR 855
Query: 663 NGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPP 722
I D +T++GL Y RL A N G + ++ + TP + P
Sbjct: 856 PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL--------PS 907
Query: 723 PPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTIRCNPVGLQNASLVLYLQTSETHM 780
P +L+ T+S+ L W P +II+YT+ + N+ L T++T
Sbjct: 908 GFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDI---NSQQELQNITTDTRF 964
Query: 781 LVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW 840
+ GL+P+T Y+ VR + S P SP + T+P +V + L+SW
Sbjct: 965 TLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK-NFRVAAAMKTSVLLSW 1023
Query: 841 KPPDGPETVVTRYTILYASRKAWIAG 866
+ PD ++ V + ILY + + G
Sbjct: 1024 EVPDSYKSAVP-FKILYNGQSVEVDG 1048
Score = 92.0 bits (227), Expect = 3e-18
Identities = 101/397 (25%), Positives = 167/397 (42%), Gaps = 50/397 (12%)
Query: 416 EDRPSAP-YNVHAETMSSSAILLAWERPLYNSD--KVIAYSVHYMKAEGLNNEE-----Y 467
ED PS P V E ++S+A+ + W+ P+ + ++ Y V Y++ E N E
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLE--NGEPRGLPII 762
Query: 468 QVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTS 527
Q V+ + I L P + Y+ + AY G S T VP RP + T+
Sbjct: 763 QDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTT 822
Query: 528 RSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVY 587
T L+ W P K G+++ YRL + + E ++ + + GL + Y
Sbjct: 823 AMNT-ALLQWHP--PKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTY 879
Query: 588 LVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDT 645
+ R+ A R GLGE RTP+ P++ LH+ L +T + W V E
Sbjct: 880 IFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQN--LHVTGLTTSTTELAWDPPVLAERN 936
Query: 646 AAIQGYKLYYKE-EGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQ 704
I Y + +++ QQE I DT+ +TL+GL P Y +++ A+ + G
Sbjct: 937 GRIISYTVVFRDINSQQELQNITTDTR---FTLTGLKPDTTYDIKVRAWTSKGSG----- 988
Query: 705 TVSTPGCVSVRDRMVPPPPPPHHLYAK-----ANTSSSIFLHWRRP-AFTAAQIINYTIR 758
P S++ R +P ++AK A +S+ L W P ++ +A
Sbjct: 989 ----PLSPSIQSRTMPV----EQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYN 1040
Query: 759 CNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
V + S+ L+ L+PNT+Y F +
Sbjct: 1041 GQSVEVDGHSM---------RKLIADLQPNTEYSFVL 1068
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/192 (26%), Positives = 87/192 (45%), Gaps = 6/192 (3%)
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHML 781
P PP L T++S+ L W + + + Y I+ G + + + T
Sbjct: 319 PKPPIDLVVTETTATSVTLTW--DSGNSEPVTYYGIQYRAAGTEGPFQEVD-GVATTRYS 375
Query: 782 VQGLEPNTKYEFAVRLHVDQLS-SPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW 840
+ GL P ++Y F V L V+ + P S V T +AP+ PP V+ ++ T LV W
Sbjct: 376 IGGLSPFSEYAFRV-LAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQW 434
Query: 841 KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE 900
+PP+ P +V Y + Y W H A + + +L+ G Y +++ A
Sbjct: 435 EPPEEPNGLVRGYRVYYTPDSRRPPNAWH-KHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493
Query: 901 VGEGPFSNSVEL 912
VG+GP S ++++
Sbjct: 494 VGDGPPSPTIQV 505
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 186 bits (473), Expect = 8e-47
Identities = 235/963 (24%), Positives = 381/963 (39%), Gaps = 136/963 (14%)
Query: 45 PQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM---SENKRIEVLSNGSLYISEVEG- 100
PQ V R + C A G ++TW K+ + + N RI+ L + + + + G
Sbjct: 141 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGA 200
Query: 101 ---RRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA-------FEVQPISTEVHEGG 150
E++D+G Y+C+A N G S A+L + + F + P+S E+ GG
Sbjct: 201 LQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGG 260
Query: 151 VARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG--VLQIYDVSQRDSGNYRCIAA 208
C P + W L D +P G VL++ DV +DS NY C+A
Sbjct: 261 NVNITCVAVGSPMPYVKWMQGAEDLTPEDD----MPVGRNVLELTDV--KDSANYTCVAM 314
Query: 209 TVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISW 268
+ +EA + K+ TP + +N TS+ T +GNP P+ S+
Sbjct: 315 SSLG---VIEAVAQITVKSLPKAPGTPMVT---ENTATSITIT-----WDSGNPDPV-SY 362
Query: 269 SRLDHKSI----------DVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAM 318
+++KS D+ TR G S+ ++V + G + ++
Sbjct: 363 YVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYE-----IWVSAVNSIGQGPPSESV 417
Query: 319 ATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKI-------HSNG 371
T T P+ P ++ + Q E P + L G ++ H G
Sbjct: 418 VTRTGEQAPASA--PRNVQARMLSATTMIVQWEEPVEP--NGLIRGYRVYYTMEPEHPVG 473
Query: 372 RIKMYNSK----LVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHA 427
+ +N + ++ ++ + +A S G + V + P P N+ A
Sbjct: 474 NWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRA 533
Query: 428 ETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPAS 487
E S ++I L+W P + +I Y + + EG + E + TT Y+++DL+P +
Sbjct: 534 EARSETSITLSWSPP--RQESIIKYELLFR--EGDHGREVGRTF-DPTTSYVVEDLKPNT 588
Query: 488 NYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISWLPIPAKYRR 546
Y F + A P G + V Q TL+ P PP ++ S T IL+SW P P +
Sbjct: 589 EYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHN 648
Query: 547 GQVVLYRLSFR-LSTEN--SIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS 603
G +V Y + +R L +E+ +V +P TT + LLE L+ + Y + A T VG G S
Sbjct: 649 GALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES 708
Query: 604 VWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYKLYY-KEEGQ 660
RT + P+ E E LN T I V W+ I+GY+++Y + EG
Sbjct: 709 SPVVVRTDEDVPSAPPRKVE--AEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGA 766
Query: 661 QENGPIFL-------------DTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA-DQTV 706
+ GP + DT + ++ L P Y + + AY DG ++ + V
Sbjct: 767 EARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVV 826
Query: 707 STPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAA-QIINYTIRCNPVGLQ 765
T G V R + P S+ W PA TA Q++ Y ++ G +
Sbjct: 827 VTKGAVLGRPTLSVQQTP----------EGSLLARWEPPAGTAEDQVLGYRLQ---FGRE 873
Query: 766 NASLVLYLQ--TSETHMLVQGLEPNTKYEFAVRLH---------VDQLSSPWSPVVYHST 814
+++ + L+ SE G+ Y F + + LS P H
Sbjct: 874 DSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQ 933
Query: 815 LPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPET--VVTRYTILYASRKAWIAG-----E 867
+ EA G T L+ W PP E + +YT+ A R+A G E
Sbjct: 934 ILEAAGNASAG---------TVLLRWLPPVPAERNGAIVKYTV--AVREAGALGPARETE 982
Query: 868 WQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVEL-AVLPKETSESNQRP 926
GA L+ L Y +++ A G GPFS V L + S N +
Sbjct: 983 LPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKV 1042
Query: 927 KRL 929
K +
Sbjct: 1043 KMI 1045
Score = 183 bits (464), Expect = 9e-46
Identities = 224/947 (23%), Positives = 382/947 (40%), Gaps = 98/947 (10%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLS--NGSLYISEV 98
F+KEP+D CQA G+ +VTW K G K++ ++R E + + + +
Sbjct: 35 FIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN-SQRFETIEFDESAGAVLRI 93
Query: 99 EGRRGEQSDEGFYQCLAMNKYGAILSQKAHLAL------STISAFEVQPISTEVHEGGVA 152
+ R + DE Y+C+A N G I L S ++ P V A
Sbjct: 94 QPLRTPR-DENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 153 RFACKISSHPPAVITW--EFNRTTLPMTMDRITALPT---------GVLQIYDVSQRDSG 201
C S +P ITW +F + RI L + G LQI + D G
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQG 212
Query: 202 NYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGN 261
Y C+A A R S A+L V +E + P P + V + C+A G+
Sbjct: 213 KYECVATNSAGVRYSSPANLYVRELREVRRV-APRFSILPMSHEIMPGGNVNITCVAVGS 271
Query: 262 PKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATL 321
P P + W + + + + +G L ++DV+ + Y C A + + A+A +
Sbjct: 272 PMPYVKWMQ-GAEDLTPEDDMPVGRNVLELTDVK--DSANYTCVAMS--SLGVIEAVAQI 326
Query: 322 TVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNG--RIK--MYN 377
TV + P P + T+ + G P P ++ + +G +IK +
Sbjct: 327 TVKSLPKAPGTP--MVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITT 384
Query: 378 SKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRP-SAPYNVHAETMSSSAIL 436
++ I + P + A NS G + E P SAP NV A +S++ ++
Sbjct: 385 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 444
Query: 437 LAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPA-------SNY 489
+ WE P+ + + Y V+Y E + +GN H + D L Y
Sbjct: 445 VQWEEPVEPNGLIRGYRVYYTM-------EPEHPVGNWQKHNVDDSLLTTVGSLLEDETY 497
Query: 490 TFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQV 549
T ++A+ +G +SD + T + VP +P + +RS T I +SW P R+ +
Sbjct: 498 TVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP----PRQESI 553
Query: 550 VLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHR 609
+ Y L FR ++ +V T Y++E LKP++ Y R+ A + GLG + R
Sbjct: 554 IKYELLFR-EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 612
Query: 610 TPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYYKEEGQQENGP-- 665
T ++ P+ ++ + T I V W+ +T A+ GY + Y+ G ++ P
Sbjct: 613 TLQSKPSAPPQ--DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKE 670
Query: 666 ---IFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPP 722
I T +L L L+ +Y + +A+ + G ++ V VR P
Sbjct: 671 VNGIPPTTTQIL--LEALEKWTQYRITTVAHTEVGPGPESSPVV-------VRTDEDVPS 721
Query: 723 PPPHHLYAKANTSSSIFLHWRRPA--FTAAQIINYTI--------------RCNPVGLQN 766
PP + A+A +++I + WR PA QI Y + R V L +
Sbjct: 722 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
Query: 767 ASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGV 826
A T+E M++ L+P T Y V + + S T P + V
Sbjct: 782 AQWETD-DTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840
Query: 827 KVTLIEDDTALVSWKPPDG-PETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENL 885
+ T + + L W+PP G E V Y + + + + E T + +
Sbjct: 841 QQT--PEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTAS---GV 895
Query: 886 VAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSA 932
G Y+ +++A + G G + E+ +P++T + P+ L++A
Sbjct: 896 HKGATYVFRLAARSRGGLG--EEAAEVLSIPEDTPRGH--PQILEAA 938
Score = 112 bits (281), Expect = 2e-24
Identities = 129/526 (24%), Positives = 219/526 (41%), Gaps = 51/526 (9%)
Query: 363 NGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAP 422
+GR++ GR + V+ + P + ++ A + QG + + +PSAP
Sbjct: 565 HGREV---GRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAP 621
Query: 423 -YNVHAETMSSSAILLAWERPL--YNSDKVIAYSVHYMKAEGLNNEEYQVV-IGNDTTHY 478
+V ++ S+AIL++W P ++ ++ YSV Y + E +V I TT
Sbjct: 622 PQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQI 681
Query: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISW 537
+++ LE + Y VA+ +G S V T EDVP PP ++ + + T I + W
Sbjct: 682 LLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLW 741
Query: 538 L-PIPAKYRRGQVVLYRLSF-RLSTENS--------IQVLELPGTT-----HEYLLEGLK 582
P P + + GQ+ Y++ + R+ + + + + T +E ++ L+
Sbjct: 742 RSPAPGR-QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQ 800
Query: 583 PDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPK--SPELHLEPLNCTTISVRWQQ 640
P++ Y + + A T G G S PK K P L ++ ++ RW+
Sbjct: 801 PETAYSITVAAYTMKGDGARS------KPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEP 854
Query: 641 DVEDTA-AIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDG 699
+ GY+L + E + + YT SG+ Y RL A + G
Sbjct: 855 PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG 914
Query: 700 YQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSS-SIFLHWRRP--AFTAAQIINYT 756
+A + +S P P P L A N S+ ++ L W P A I+ YT
Sbjct: 915 EEAAEVLSIPEDT--------PRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966
Query: 757 IRCNPVGLQNASLVLYLQTS-----ETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVY 811
+ G + L + E + +QGL+P+T Y+ VR H + P+SP V
Sbjct: 967 VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1026
Query: 812 HSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILY 857
+ T P KV +I + L+SW+ PD + T Y I Y
Sbjct: 1027 YRTFLRDQVSPK-NFKVKMIMKTSVLLSWEFPDNYNS-PTPYKIQY 1070
Score = 89.7 bits (221), Expect = 1e-17
Identities = 120/482 (24%), Positives = 183/482 (37%), Gaps = 57/482 (11%)
Query: 410 LTVVMSEDRPSAP-YNVHAETMSSSAILLAWERPLYNSD--KVIAYSVHYMKAEG----- 461
+ V ED PSAP V AE ++++AI + W P ++ Y VHY++ EG
Sbjct: 711 VVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARG 770
Query: 462 --------LNNEEYQVVIGNDTTHY--IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQN 511
L + +++ +DT Y +I +L+P + Y+ + AY G S
Sbjct: 771 PPRIKDVMLADAQWET---DDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVV 827
Query: 512 TLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPG 571
T V L P +S+ +L W P PA QV+ YRL F + LE P
Sbjct: 828 TKGAV-LGRPTLSVQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGREDSTPLATLEFPP 885
Query: 572 TTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNC 631
+ Y G+ + Y+ R+ A +R GLGE + P+ T P+ E +
Sbjct: 886 SEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLS-IPEDTPRGHPQILEA-AGNASA 943
Query: 632 TTISVRWQQDV--EDTAAIQGYKLYYKEEG------QQENGPIFLDTKDLLYTLSGLDPR 683
T+ +RW V E AI Y + +E G + E + TL GL P
Sbjct: 944 GTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPD 1003
Query: 684 RKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDR-MVPPPPPPHHLYAKANTSSSIFLHW 742
Y +++ A+ G P VR R + P + K +S+ L W
Sbjct: 1004 TAYDLQVRAHTRRGPG---------PFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSW 1054
Query: 743 RRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQL 802
P NY P +Q L L + T L+ L+P+T Y F + L
Sbjct: 1055 EFPD-------NYNSP-TPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSL 1106
Query: 803 SSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDG--PETVVTRYTILYASR 860
V + P V K D + PDG P V + + ++ R
Sbjct: 1107 GGLQQTVTAWTAFNLLNGKPSVAPK----PDADGFIMVYLPDGQSPVPVQSYFIVMVPLR 1162
Query: 861 KA 862
K+
Sbjct: 1163 KS 1164
Score = 71.6 bits (174), Expect = 4e-12
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 14/131 (10%)
Query: 309 PGTRNFTVAMATLTVLA--------PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
PG + M L VL PP F++ P+ G A FVCQA G P P+++W
Sbjct: 7 PGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTW 66
Query: 361 LKNGRKIHSN--GRIKMYNSKLVINQI----IPEDDAIYQCMAENSQGSILSRARLTVVM 414
K G+K++S I+ S + +I P D+ +Y+C+A+NS G I A+LTV+
Sbjct: 67 NKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLR 126
Query: 415 SEDRPSAPYNV 425
+ PS N+
Sbjct: 127 EDQLPSGFPNI 137
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 186 bits (471), Expect = 1e-46
Identities = 217/939 (23%), Positives = 373/939 (39%), Gaps = 73/939 (7%)
Query: 1 MAPPLRPLARLRPPGMLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDC 60
MAP P + P L+ AL++L L++ G S+ F+K P+D T C
Sbjct: 1 MAPEPAPGRTMVP---LVPALVMLGLVAGAHGD---SKPVFIKVPEDQTGLSGGVASFVC 54
Query: 61 QAHGEVPIKVTWLKNGAKMSENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNK 118
QA GE ++TW+K G K+S ++R EV+ +G+ + ++ R Q DE Y+C A N
Sbjct: 55 QATGEPKPRITWMKKGKKVS-SQRFEVIEFDDGAGSVLRIQPLR-VQRDEAIYECTATNS 112
Query: 119 YGAILSQKAHLALST------ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EF 170
G I + L + ++ P V + A C +P I+W +F
Sbjct: 113 LGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDF 172
Query: 171 NRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESK 230
+ RI L +G LQI + D G Y C+A A R S A+L V + +
Sbjct: 173 LPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAP 232
Query: 231 SFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLM 290
F P P + +V L C+A G P P + W + + + + +G L
Sbjct: 233 RFSIP-----PSSQEVMPGGSVNLTCVAVGAPMPYVKW-MMGAEELTKEDEMPVGRNVLE 286
Query: 291 ISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQA 350
+S+V + Y C A + A T+ L P + + T+ +
Sbjct: 287 LSNV--VRSANYTCVAISSLGMIEATAQVTVKALPKPPI----DLVVTETTATSVTLTWD 340
Query: 351 EGIPSPKMSWLKNGRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILS 406
G P + R + G + + ++ I + P + ++ +A NS G
Sbjct: 341 SGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPP 400
Query: 407 RARLTVVMSEDRPSA-PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNE 465
+ E PS+ P V A +S+S +L+ WE P + V Y V+Y
Sbjct: 401 SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPN 460
Query: 466 EYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISL 525
+ + + L P Y+ ++A+ +G S + T + VP +P +
Sbjct: 461 AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQA 520
Query: 526 TSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDS 585
S T I +SWL P + ++++Y L + + + Q T Y LE LKPD+
Sbjct: 521 EVESDTRIQLSWLLPPQE----RIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDT 576
Query: 586 VYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT 645
+Y ++ A + +G+G + RT ++T P+ ++ + TT+ V W D+
Sbjct: 577 LYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQ--KVMCVSMGSTTVRVSWVPPPADS 634
Query: 646 --AAIQGYKLYYKEEGQQENGPIFLD---TKDLLYTLSGLDPRRKYHVRLLAYNNIDDGY 700
I Y + Y+ ++ G +D + + L GL+ +Y V + A+ ++ G
Sbjct: 635 RNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGP 694
Query: 701 QADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTI- 757
+ S+P V VR P PP + + S+++ ++W+ P + QI Y +
Sbjct: 695 E-----SSP--VLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVT 747
Query: 758 -----RCNPVGLQNASLVLYL-------QTSETHMLVQGLEPNTKYEFAVRLHVDQLSSP 805
P GL V+ ++ + + GL P T Y V + +
Sbjct: 748 YVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGA 807
Query: 806 WSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIA 865
S +T P P + + T + +TAL+ W PP + Y + Y
Sbjct: 808 RSKPKIVTTTGAVPGRPTMMISTTAM--NTALLQWHPPKELPGELLGYRLQYCRADEARP 865
Query: 866 GEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEG 904
+ T+ L G YI +++A N G G
Sbjct: 866 NTIDFGKDDQHFTVT---GLHKGTTYIFRLAAKNRAGLG 901
Score = 140 bits (353), Expect = 7e-33
Identities = 133/524 (25%), Positives = 215/524 (41%), Gaps = 48/524 (9%)
Query: 419 PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY 478
P+ P + AE S + I L+W P +++I Y + Y AE + ++ V + T+ Y
Sbjct: 512 PAQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAE--DEDQQHKVTFDPTSSY 567
Query: 479 IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISW 537
++DL+P + Y F + A MG + + T + P PP+ + S T + +SW
Sbjct: 568 TLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSW 627
Query: 538 LPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYL---LEGLKPDSVYLVRITAA 594
+P PA R G + Y +++ + G + E+ L GL+ + Y V + A
Sbjct: 628 VPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAH 687
Query: 595 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV--EDTAAIQGYK 652
T VG G S RT + P+ E+ EPLN T + V W+ V + I+GY+
Sbjct: 688 TDVGPGPESSPVLVRTDEDVPSGPPRKVEV--EPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 653 LYYK--EEGQQENGPIFLD------------TKDLLYTLSGLDPRRKYHVRLLAYNNIDD 698
+ Y E G+ PI D ++D T+SGL P Y V + AY D
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
Query: 699 GYQAD-QTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTI 757
G ++ + V+T G V R M+ ++ L W P +++ Y +
Sbjct: 806 GARSKPKIVTTTGAVPGRPTMM----------ISTTAMNTALLQWHPPKELPGELLGYRL 855
Query: 758 RCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPE 817
+ + + + + + H V GL T Y F RL + PE
Sbjct: 856 QYCRADEARPNTIDFGKDDQ-HFTVTGLHKGTTYIF--RLAAKNRAGLGEEFEKEIRTPE 912
Query: 818 -APAGPPVGVKVTLIEDDTALVSWKPPDGPETV--VTRYTILYASRKAWIAGEWQVLHRE 874
P+G P + VT + T ++W PP E + YT+++ Q L
Sbjct: 913 DLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD-----INSQQELQNI 967
Query: 875 GAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKE 918
T L L Y +K+ A G GP S S++ +P E
Sbjct: 968 TTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE 1011
Score = 124 bits (312), Expect = 4e-28
Identities = 127/514 (24%), Positives = 220/514 (42%), Gaps = 46/514 (8%)
Query: 378 SKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAP-YNVHAETMSSSAIL 436
S + + P+ +Q A + G + + ++ PSAP V +M S+ +
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
Query: 437 LAWERPLYNSDK--VIAYSVHYMKAEGLNNEEYQVV-IGNDTTHYIIDDLEPASNYTFYI 493
++W P +S + YSV Y +G + + V I + + + + LE + Y ++
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWV 684
Query: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISW-LPIPAKYRRGQVVL 551
A+ +G S V T EDVP PP ++ + + T + + W LP+P+K + GQ+
Sbjct: 685 RAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSK-QHGQIRG 743
Query: 552 YRLSFRLSTENS-------IQVLEL------PGTTHEY--LLEGLKPDSVYLVRITAATR 596
Y++++ + EN IQ + L P + +Y + GL P++ Y V + A T
Sbjct: 744 YQVTY-VRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTT 802
Query: 597 VGLGESSVWTSHRTPK--ATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLY 654
G G S PK T+ P P + + T ++W E + GY+L
Sbjct: 803 KGDGARS------KPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQ 856
Query: 655 YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSV 714
Y + I D +T++GL Y RL A N G + ++ + TP +
Sbjct: 857 YCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL-- 914
Query: 715 RDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTA--AQIINYTIRCNPVGLQNASLVLY 772
P P +L+ T+S+ L W P +II+YT+ + N+ L
Sbjct: 915 ------PSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDI---NSQQELQ 965
Query: 773 LQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIE 832
T++T + GL+P+T Y+ VR + S P SP + T+P +V
Sbjct: 966 NITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK-NFRVAAAM 1024
Query: 833 DDTALVSWKPPDGPETVVTRYTILYASRKAWIAG 866
+ L+SW+ PD ++ V + ILY + + G
Sbjct: 1025 KTSVLLSWEVPDSYKSAVP-FKILYNGQSVEVDG 1057
Score = 88.2 bits (217), Expect = 4e-17
Identities = 101/406 (24%), Positives = 166/406 (40%), Gaps = 59/406 (14%)
Query: 416 EDRPSAP-YNVHAETMSSSAILLAWERPLYNSD--KVIAYSVHYMKAEGLNNEEYQVVIG 472
ED PS P V E ++S+A+ + W+ P+ + ++ Y V Y++ E N E + I
Sbjct: 705 EDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLE--NGEPRGLPII 762
Query: 473 NDTT--------------HYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPL 518
D I L P + Y+ + AY G S T VP
Sbjct: 763 QDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPG 822
Query: 519 RPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLL 578
RP + T+ T L+ W P K G+++ YRL + + E ++ + +
Sbjct: 823 RPTMMISTTAMNT-ALLQWHP--PKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV 879
Query: 579 EGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRW 638
GL + Y+ R+ A R GLGE RTP+ P++ LH+ L +T + W
Sbjct: 880 TGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQN--LHVTGLTTSTTELAW 936
Query: 639 QQDV--EDTAAIQGYKLYYKE-EGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNN 695
V E I Y + +++ QQE I DT+ +TL+GL P Y +++ A+ +
Sbjct: 937 DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTR---FTLTGLKPDTTYDIKVRAWTS 993
Query: 696 IDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAK-----ANTSSSIFLHWRRP-AFTA 749
G P S++ R +P ++AK A +S+ L W P ++ +
Sbjct: 994 KGSG---------PLSPSIQSRTMPV----EQVFAKNFRVAAAMKTSVLLSWEVPDSYKS 1040
Query: 750 AQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
A V + S+ L+ L+PNT+Y F +
Sbjct: 1041 AVPFKILYNGQSVEVDGHSM---------RKLIADLQPNTEYSFVL 1077
Score = 68.9 bits (167), Expect = 3e-11
Identities = 51/192 (26%), Positives = 87/192 (45%), Gaps = 6/192 (3%)
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHML 781
P PP L T++S+ L W + + + Y I+ G + + + T
Sbjct: 319 PKPPIDLVVTETTATSVTLTW--DSGNSEPVTYYGIQYRAAGTEGPFQEVD-GVATTRYS 375
Query: 782 VQGLEPNTKYEFAVRLHVDQLS-SPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSW 840
+ GL P ++Y F V L V+ + P S V T +AP+ PP V+ ++ T LV W
Sbjct: 376 IGGLSPFSEYAFRV-LAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQW 434
Query: 841 KPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNE 900
+PP+ P +V Y + Y W H A + + +L+ G Y +++ A
Sbjct: 435 EPPEEPNGLVRGYRVYYTPDSRRPPNAWH-KHNTDAGLLTTVGSLLPGITYSLRVLAFTA 493
Query: 901 VGEGPFSNSVEL 912
VG+GP S ++++
Sbjct: 494 VGDGPPSPTIQV 505
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 181 bits (458), Expect = 5e-45
Identities = 213/851 (25%), Positives = 342/851 (40%), Gaps = 70/851 (8%)
Query: 56 VVLDCQAHGEVPIK--VTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQC 113
V L+C A+ IK + W K+G +S N L I G SD G+Y+C
Sbjct: 233 VTLECVANARPLIKLHIIWKKDGVLLSGGISDH---NRRLTIPNPTG-----SDAGYYEC 284
Query: 114 LAMNKYGAILS--QKAHLALSTISAFEVQP---ISTEVHEGGVARFACKISSHPPAVITW 168
A+ + ++ S + A+L++ F +P I+ E+ + V C+ PP ITW
Sbjct: 285 EAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEK--VVDIPCQAKGVPPPSITW 342
Query: 169 EFNRTTLPMT-MDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHR-RKSMEASLTVIPA 226
+ + + + R G LQI + D+G ++C A A + S ++T I
Sbjct: 343 YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI-- 400
Query: 227 KESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSR----LDHKSIDVFNTR 282
P I GP + T +VVL C +G P+P I+W + L S+ +
Sbjct: 401 -------APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFT 453
Query: 283 VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
L +G+L+IS + AG Y C AT +R A A L V A + P+ + +
Sbjct: 454 PLESGSLLISPTHISDAGTYTCLATN--SRGVDEASADLVVWARTRITKPPQDQSVIKGT 511
Query: 343 TARFVCQAEGIP--SPKMSWLKNGRKI--HSNGRIKM-YNSKLVINQIIPEDDAIYQCMA 397
A VC P + + W K+G + S+ RI++ N L I+Q D Y C
Sbjct: 512 QASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRV 571
Query: 398 ENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYM 457
++ G+ A L V P P T+ AI L W +P + +I Y +
Sbjct: 572 ISAGGNDSRSAHLRVRQLPHAPEHPVAT-LSTVERRAINLTWTKPFDGNSPLIRYILEMS 630
Query: 458 KAEGLNNEEYQVVIGN---DTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTL- 513
+ NN + V++ + T + L PA +Y F + A +G Q S + +L
Sbjct: 631 E----NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLP 686
Query: 514 EDVPLRPPEISLTS-RSPTDILISWLPIPAKYRRGQVVLYRLSFRLS-TENSIQVLELPG 571
E+ P PP+ + S R+ I+I W P P ++ G + Y + + L+ Q +
Sbjct: 687 EEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITD 746
Query: 572 T-THEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLN 630
+ LLE L + Y + + A GLG S + T + P + +H E N
Sbjct: 747 ADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGN--VHAEATN 804
Query: 631 CTTISVRWQQDVED--TAAIQGYKLYYKEEGQQEN------GPIFLDTKDLLYTLSGLDP 682
TTI W QGYKL E Q+E P F D+ + + +SGL
Sbjct: 805 STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKK 863
Query: 683 RRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHW 742
+Y +L + DG + STP V + + P P HL +S+ + W
Sbjct: 864 FTEYFTSVLCFTTPGDGPR-----STPQLVRTHEDV---PGPVGHLSFSEILDTSLKVSW 915
Query: 743 RRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQL 802
+ P + Y I N + YL V GL T Y V +
Sbjct: 916 QEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG 975
Query: 803 SSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKA 862
S S +P GPP + ++ I + + ++P +T ++R+ +
Sbjct: 976 QGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVV 1035
Query: 863 WIAGEWQVLHR 873
EW ++H+
Sbjct: 1036 GEGEEWLLIHQ 1046
Score = 162 bits (409), Expect = 2e-39
Identities = 222/917 (24%), Positives = 378/917 (41%), Gaps = 83/917 (9%)
Query: 41 FVKEPQ-DVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK--RIEVLSNGSLYISE 97
FVKEP+ +T + V + CQA G P +TW K+ A + K R ++G L IS
Sbjct: 310 FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 369
Query: 98 VEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQ-PISTEVHEGGVARFAC 156
+ D G +QC A N G + +LA+++I+ + P+ + V +G AC
Sbjct: 370 L-----VPDDTGMFQCFARNAAGEV-QTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLAC 423
Query: 157 KISSHPPAVITWEFNRTTL---PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHR 213
+ S P ITW+ L + + R T L +G L I D+G Y C+A +
Sbjct: 424 ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA---TNS 480
Query: 214 RKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIIS--WSRL 271
R EAS ++ ++ I PQ+ + + C T +P+ I W +
Sbjct: 481 RGVDEASADLVVWARTR------ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK- 533
Query: 272 DHKSIDVFN---TRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPS 328
D ++ + R+ NG+L IS G Y CR + G + A L V P
Sbjct: 534 DGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND--SRSAHLRVRQLPH 591
Query: 329 FVEWPE---SLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYN-----SKL 380
E P S RA + +G SP + ++ + ++ + + + + +
Sbjct: 592 APEHPVATLSTVERRAINLTWTKPFDG-NSPLIRYILEMSENNAPWTVLLASVDPKATSV 650
Query: 381 VINQIIPEDDAIYQCMAENSQG-SILSRARLTVVMSEDRPSA-PYNVHAETMSSSAILLA 438
+ ++P ++ A N G S+ V + E+ P+A P NV A ++ +I++
Sbjct: 651 TVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQ 710
Query: 439 WERPLYNSDKVI--AYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAY 496
W+ P + I Y + Y A +++ + D + +++DL +NY + AY
Sbjct: 711 WQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAY 770
Query: 497 MPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISWLPIPAKYRRGQVVLYRL- 554
G S VT+ TL+ VP PP + + + T I +W ++ G Y+L
Sbjct: 771 NSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLI 830
Query: 555 SFRLSTENSIQVL----ELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRT 610
++ E + ++ + H + GLK + Y + T G G S RT
Sbjct: 831 AWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRT 890
Query: 611 PKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPI--FL 668
+ V P L + T++ V WQ+ E + GY++ + EE + N + +L
Sbjct: 891 HE--DVPGPVG-HLSFSEILDTSLKVSWQEPGEKNGILTGYRISW-EEYNRTNTRVTHYL 946
Query: 669 DTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPP--PPPPH 726
L Y ++GL Y + + A + G + T+S+ VPP P PP
Sbjct: 947 PNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSG---------VPPELPGPPT 997
Query: 727 HLYAKANTSSSIFLHWRRPAFTAAQIINYTI---RCNPVGLQNASLVLYLQTSE---THM 780
+L S+ L + RP + I+ + + VG L+++ ++E M
Sbjct: 998 NLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 1056
Query: 781 LVQGLEPNTKYEFAVR-LHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVS 839
V L P T Y F +R +++ S P P TL P P V + + + +
Sbjct: 1057 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLR 1116
Query: 840 WKP-PD-----GPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIV 893
W P P+ PE+V Y I Y SR + ++ +E+L Y V
Sbjct: 1117 WMPLPEMEYNGNPESV--GYKIKY-SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRV 1173
Query: 894 KISASNEVGEGPFSNSV 910
++ A N +G GP+S +V
Sbjct: 1174 QVQAFNAIGSGPWSQTV 1190
Score = 120 bits (300), Expect = 1e-26
Identities = 124/530 (23%), Positives = 215/530 (40%), Gaps = 52/530 (9%)
Query: 420 SAPYNVHAETMSSSAILLAWERPLYNSDK---VIAYSVHYMKAEGLNNEEYQVVIGNDTT 476
S P NV A +SS++L+ W + +D+ V+ Y V Y + + + +V GN +
Sbjct: 1201 SGPTNVSALATTSSSMLVRWSE-VPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR 1259
Query: 477 HYIIDDLEPASNYTFYIVAYMPMG-ASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILI 535
+ L Y ++A+ +G S + + TL+DVP P I T + +
Sbjct: 1260 SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRL 1319
Query: 536 SWLPIPAKYRRGQVVLYRLSFRLSTE--NSIQVLELPGTTHEYLLEGLKPDSVYLVRITA 593
W P A G ++ Y+++ RL+T N+ V L + +Y GLKP+SVYL RITA
Sbjct: 1320 IWQPPAAP--NGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITA 1377
Query: 594 ATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKL 653
TR G GE++ T K + P P + E + ++ + W+ + + ++ Y +
Sbjct: 1378 QTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTI 1437
Query: 654 YYKE--EGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGC 711
+E G+ + + + L P Y R+ A N+I D ++++
Sbjct: 1438 QTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEES------ 1491
Query: 712 VSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQ--IINYTIRCNPV------- 762
S+ P P L +T++S+ + W+ PA ++ + IR +
Sbjct: 1492 ESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG 1551
Query: 763 ----GLQNA-----------SLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWS 807
G+ N S+ + S T + L + +YE + ++ P S
Sbjct: 1552 FTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSS 1611
Query: 808 PVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPP--DGPETVVTRYTILYASRKAWIA 865
P P P V V V+W+PP D + Y I + W A
Sbjct: 1612 PPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF-----WEA 1666
Query: 866 GEWQVLHREGAITMA----LLENLVAGNVYIVKISASNEVGEGPFSNSVE 911
+ R + +A L+NL Y+V ++A N G+GP S +
Sbjct: 1667 QRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ 1716
Score = 110 bits (276), Expect = 6e-24
Identities = 98/367 (26%), Positives = 163/367 (44%), Gaps = 23/367 (6%)
Query: 56 VVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLA 115
+VL C A G P++ WL N ++++ SL +++ GFY+C+
Sbjct: 44 LVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSL----------DRTHAGFYRCIV 93
Query: 116 MNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARF-ACKISSHPPAVITWEFNRTT 174
N+ GA+L ++ + ++ + +FE V G A A +I+S P +TW +
Sbjct: 94 RNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRK 153
Query: 175 LPMTMDRITALPTGVLQIYDVSQRDSGNY--RCIAATVAHRRKSMEASLTVIPAKESKSF 232
+P + RI L I D+G Y + + + S +LTV
Sbjct: 154 IPPS-SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADP 212
Query: 233 HTPTIIAGPQNITTSLHQT-VVLECMATGNPKPIISWSRLDHKSIDVFNTRVLG-NGNLM 290
PTII P+N + + V LEC+A N +P+I + K + + + N L
Sbjct: 213 IAPTIIIPPKNTSVVAGTSEVTLECVA--NARPLIKLHIIWKKDGVLLSGGISDHNRRLT 270
Query: 291 ISDVRLQHAGVYVCRATTPGTRNFTVAM-ATLTVLAPPSFVEWPE-SLTRPRAGTARFVC 348
I + AG Y C A + +V A L+VL PP FV+ PE +T C
Sbjct: 271 IPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPC 330
Query: 349 QAEGIPSPKMSWLKNGR--KIHSNGRIKMYN-SKLVINQIIPEDDAIYQCMAENSQGSIL 405
QA+G+P P ++W K+ ++ R + N L I+ ++P+D ++QC A N+ G +
Sbjct: 331 QAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390
Query: 406 SRARLTV 412
+ L V
Sbjct: 391 TSTYLAV 397
Score = 110 bits (275), Expect = 8e-24
Identities = 134/534 (25%), Positives = 218/534 (40%), Gaps = 54/534 (10%)
Query: 421 APYNVHAETMSSSAILLAWERPL----YNSD-KVIAYSVHYMKAEGLNNEEYQVVIGNDT 475
AP NV T S +++ L W PL YN + + + Y + Y +++G VV
Sbjct: 1099 APANVSLRTASETSLWLRW-MPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVE 1157
Query: 476 THYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLR-PPEISLTSRSPTDIL 534
Y I+DLE + Y + A+ +G+ S V T E VP P +S + + + +L
Sbjct: 1158 RDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSML 1217
Query: 535 ISWLPIPAKYRRGQVVLYRLSFR---LSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRI 591
+ W +P R G V+ Y++ ++ T+ ++E ++ L GL +Y V++
Sbjct: 1218 VRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVE-GNSSRSAQLTGLGKYVLYEVQV 1276
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEP-LNCTTISVRWQQDVEDTAAIQG 650
A TR+G G S + T P P L P + T++ + WQ I
Sbjct: 1277 LAFTRIGDGSPS---HPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILA 1333
Query: 651 YKLYYKEEGQQENGPI--FLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVST 708
Y++ ++ N L YT +GL P Y R+ A G A+ V T
Sbjct: 1334 YQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVT 1393
Query: 709 PGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPV-----G 763
RDR P PP + + + S+ L W + + + YTI+ +
Sbjct: 1394 ---TEKRDR--PQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWA 1448
Query: 764 LQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH-STLPEAPAGP 822
L +AS + + + +V L+P T Y+F V+ D S +S +TL AP
Sbjct: 1449 LHSAS----VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA 1504
Query: 823 PVGVKVTLIEDDTALVSWKPP--DGPETVVTRYTI-----LYASRKAWI-------AGEW 868
P + VT + L+ W+PP D ++ + I LY + + W
Sbjct: 1505 PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATW 1564
Query: 869 QVLH--------REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAV 914
L ++T L+NL Y +++S N VGEGP S E+ V
Sbjct: 1565 AELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV 1618
Score = 104 bits (260), Expect = 4e-22
Identities = 145/647 (22%), Positives = 252/647 (38%), Gaps = 86/647 (13%)
Query: 387 PEDDAIYQCMAENSQG-SILSRARLTVVMSEDRPSAPYN--VHAETMSSSAILLAWERPL 443
PE +++ A+ +G + A + DRP P V E + + ++LL+WE
Sbjct: 1367 PESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS 1426
Query: 444 YNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQ 503
V Y++ + + + ++ + +I+D L+P ++Y F + A +G S+
Sbjct: 1427 DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
Query: 504 MSDHVTQ-NTLEDVPLRPPEI-SLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFR---- 557
S+ TL+ P P I S+T + T +LI W P G ++ +R+ +R
Sbjct: 1487 FSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLY 1546
Query: 558 --------------------LSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRV 597
L++ S++ L P T +Y L+ L Y +R++ V
Sbjct: 1547 EGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT-QYELDNLNKHRRYEIRMSVYNAV 1605
Query: 598 GLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQGYKLYY 655
G G SS +A AP++ +H T + V W+ D+ IQGYK+Y+
Sbjct: 1606 GEGPSSPPQEVFVGEAVPTAAPRNVVVH--GATATQLDVTWEPPPLDSQNGDIQGYKIYF 1663
Query: 656 KEEGQQENGPIFLDTKDLLYT-----LSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPG 710
E + G + K L L L Y V + A+N DG ++ T
Sbjct: 1664 WEA---QRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG--- 1717
Query: 711 CVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTI---RCNPV-GLQN 766
P P + T++S+ + W P F + Y + C+PV G+
Sbjct: 1718 -----QTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSK 1772
Query: 767 ASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGV 826
V S + V+ L Y F +R V +T P A P GV
Sbjct: 1773 IVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANV--TTGPGEGAPGPPGV 1830
Query: 827 KVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVL----HREGAITMALL 882
+ + + W D + +TRY I + G W +L +E + +
Sbjct: 1831 PIIVRYSSAIAIHWSSGDPGKGPITRYVI---EARPSDEGLWDILIKDIPKEVSSYTFSM 1887
Query: 883 ENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYH 942
+ L G Y ++ A N+ G G P S+S K + ++
Sbjct: 1888 DILKPGVSYDFRVIAVNDYGFG----------TPSSPSQSVPAQK----------ANPFY 1927
Query: 943 LDQKSMTGIAVGVGIALTCILICVLILIYRSK--ARKSSASKTAQNG 987
+ + IA+ VG+ +L+ VLI+ +SK A+K+ + +A++G
Sbjct: 1928 EEWWFLVVIAL-VGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSG 1973
Score = 101 bits (252), Expect = 4e-21
Identities = 205/930 (22%), Positives = 328/930 (35%), Gaps = 112/930 (12%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK----RIEVLSNGSLYI 95
+ + P D TV VVL C+ G +TW K ++ R L +GSL I
Sbjct: 403 NITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLI 462
Query: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFA 155
S SD G Y CLA N G + A L + + P V +G A
Sbjct: 463 SPT-----HISDAGTYTCLATNSRG-VDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516
Query: 156 CKISSHPPAVI--TWEFNRTTL-PMTMDRITALPTGVLQIYDVSQRDSGNYRC-IAATVA 211
C ++ P I WE + TL + RI G L I D G Y C + +
Sbjct: 517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGG 576
Query: 212 HRRKSMEASLTVIP-AKESKSFHTPTIIAGPQNIT-------TSLHQTVVLECMATGNPK 263
+ +S + +P A E T+ N+T S +LE P
Sbjct: 577 NDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP- 635
Query: 264 PIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTV 323
W+ L S+D T V G + + + +C G F+ +++
Sbjct: 636 ----WTVL-LASVDPKATSVTVKGLVPARSYQFR-----LCAVNDVGKGQFSKDTERVSL 685
Query: 324 LAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLV-- 381
P P A + S + W + + H NG +K Y +
Sbjct: 686 PEEP-----------PTAPPQNVIASGRTNQSIMIQW-QPPPESHQNGILKGYIIRYCLA 733
Query: 382 ---------------INQIIPEDDAIY-----QCMAENSQGSILSRARLTVVMSEDRPSA 421
+N ++ ED I+ + A NS G + +++T + P+
Sbjct: 734 GLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV 793
Query: 422 -PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIG----NDTT 476
P NVHAE +S+ I W P I + E EE +V D+
Sbjct: 794 PPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSI 853
Query: 477 HY-IIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILI 535
H + L+ + Y ++ + G S T EDVP +S + T + +
Sbjct: 854 HVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKV 913
Query: 536 SWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLE-LPGTTHEYLLEGLKPDSVYLVRITAA 594
SW P + + G + YR+S+ + +V LP T EY + GL + Y + + A
Sbjct: 914 SWQE-PGE-KNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAM 971
Query: 595 TRVGLGESSVWT----------SHRTPKATSVKAPKSPELHLEP-LNCTTISVRWQQDVE 643
T G G+ S T T S P+S L P + T RW VE
Sbjct: 972 TSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWL--VE 1029
Query: 644 DTAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
+ G + Q N P D + + + L+P Y R+ N +
Sbjct: 1030 AQVGVVGEGEEWLLIHQLSNEP---DARSM--EVPDLNPFTCYSFRMRQVNIVG------ 1078
Query: 704 QTVSTPGCVS--VRDRMVPPPPPPHHLYAKANTSSSIFLHW----RRPAFTAAQIINYTI 757
S P S ++ PP P ++ + + +S++L W + + Y I
Sbjct: 1079 --TSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKI 1136
Query: 758 RCNPVGLQNASLVLYLQTS-ETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLP 816
+ + +L +Q E ++ LE T+Y V+ S PWS V T
Sbjct: 1137 KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRE 1196
Query: 817 EAPAGPPVGVKVTLIEDDTALVSWK--PPDGPETVVTRYTILYASRKAWIAGEWQVLHRE 874
P+ P V + LV W P +V Y ++Y + + + ++
Sbjct: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
Query: 875 GAITMALLENLVAGNVYIVKISASNEVGEG 904
+ A L L +Y V++ A +G+G
Sbjct: 1257 SS-RSAQLTGLGKYVLYEVQVLAFTRIGDG 1285
Score = 101 bits (251), Expect = 5e-21
Identities = 200/892 (22%), Positives = 331/892 (37%), Gaps = 86/892 (9%)
Query: 69 KVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAI--LSQK 126
+VTW ++G K+ + RI + +L I D G Y A+N SQ
Sbjct: 144 QVTWFRDGRKIPPSSRIAITLENTLVILSTVA-----PDAGRYYVQAVNDKNGDNKTSQP 198
Query: 127 AHLALSTISA--------FEVQPISTEVHEG-GVARFACKISSHP--PAVITWEFNRTTL 175
L + + + P +T V G C ++ P I W+ + L
Sbjct: 199 ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL 258
Query: 176 PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTP 235
+ L I + + D+G Y C A R S S V+ P
Sbjct: 259 SGGISDHNRR----LTIPNPTGSDAGYYECEAVL----RSSSVPS--VVRGAYLSVLEPP 308
Query: 236 TIIAGPQ-NITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNT---RVLGNGNLMI 291
+ P+ +IT + + V + C A G P P I+W + D ++V R +G L I
Sbjct: 309 QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK-DAAVVEVEKLTRFRQRNDGGLQI 367
Query: 292 SDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAE 351
S + G++ C A T +T +AP + P T + C+
Sbjct: 368 SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP-NITRGPLDSTVIDGMSVVLACETS 426
Query: 352 GIPSPKMSWLKNGRKIHSNGRIKM------YNSKLVINQIIPEDDAIYQCMAENSQGSIL 405
G P P ++W K G +I ++G +++ + L+I+ D Y C+A NS+G
Sbjct: 427 GAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE 485
Query: 406 SRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNE 465
+ A L VV + R + P + + A ++ + + +V + L E
Sbjct: 486 ASADL-VVWARTRITKPPQDQSVIKGTQASMVCG---VTHDPRVTIRYIWEKDGATLGTE 541
Query: 466 EYQVVI--GNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEI 523
+ + N + H YT +++ G S H+ L P P
Sbjct: 542 SHPRIRLDRNGSLHISQTWSGDIGTYTCRVIS--AGGNDSRSAHLRVRQLPHAP-EHPVA 598
Query: 524 SLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENS---IQVLELPGTTHEYLLEG 580
+L++ I ++W K G L R +S N+ + + + ++G
Sbjct: 599 TLSTVERRAINLTW----TKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKG 654
Query: 581 LKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQ 640
L P Y R+ A VG G+ S T + AP + N +I ++WQ
Sbjct: 655 LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN-QSIMIQWQP 713
Query: 641 DVED--TAAIQGYKLYY----KEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN 694
E ++GY + Y G Q D +LL L L Y + + AYN
Sbjct: 714 PPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLL--LEDLIIWTNYEIEVAAYN 771
Query: 695 NIDDG-YQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQII 753
+ G Y + T T V P PP +++A+A S++I W P+ I
Sbjct: 772 SAGLGVYSSKVTEWTLQGV--------PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823
Query: 754 NY---TIRCNPVGLQNASLVLY---LQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWS 807
N I P + ++V Q S V GL+ T+Y +V P S
Sbjct: 824 NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS 883
Query: 808 PVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGE 867
T + P GP + + I D + VSW+ P ++T Y I S + +
Sbjct: 884 TPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRI---SWEEYNRTN 939
Query: 868 WQVLHREGAITMAL-LENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKE 918
+V H +T+ + L A Y ++++A G+G S S + +P E
Sbjct: 940 TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPE 991
Score = 84.0 bits (206), Expect = 8e-16
Identities = 102/481 (21%), Positives = 182/481 (37%), Gaps = 56/481 (11%)
Query: 416 EDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDT 475
+D P P + + ++++ L W+ P + ++AY + + N V+
Sbjct: 1298 DDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA 1357
Query: 476 THYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPT---D 532
Y L+P S Y F I A G + ++ + T + +PP + +
Sbjct: 1358 RQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARS 1417
Query: 533 ILISWLP-----IPAKYRRGQVVLYRLSFR--LSTENSIQVLELPGTTHEYLLEGLKPDS 585
+L+SW P P +Y Y + R S ++ + ++++ LKP +
Sbjct: 1418 VLLSWEPGSDGLSPVRY-------YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFT 1470
Query: 586 VYLVRITAATRVGLGE-SSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVED 644
Y R+ A +G E S S T +A +AP L + P T++ +RWQ ED
Sbjct: 1471 SYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI--LSVTPHTTTSVLIRWQPPAED 1528
Query: 645 --TAAIQGYKLYYKE-----------EGQQENGPIFLDTKDLL------------YTLSG 679
+ G+++ Y+E G G + + + Y L
Sbjct: 1529 KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDN 1588
Query: 680 LDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIF 739
L+ R+Y +R+ YN + +G S P V V + + P P ++ T++ +
Sbjct: 1589 LNKHRRYEIRMSVYNAVGEG-----PSSPPQEVFVGEAV--PTAAPRNVVVHGATATQLD 1641
Query: 740 LHWRRPAFTA--AQIINYTIRCNPVGLQN-ASLVLYLQTSETHMLVQGLEPNTKYEFAVR 796
+ W P + I Y I N V L +E + ++ L T Y +V
Sbjct: 1642 VTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVA 1701
Query: 797 LHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTIL 856
P S T AP+ P VK + + + VSW+ P P ++ Y ++
Sbjct: 1702 AFNAAGDGPRSTPTQGQTQQAAPSAPS-SVKFSELTTTSVNVSWEAPQFPNGILEGYRLV 1760
Query: 857 Y 857
Y
Sbjct: 1761 Y 1761
Score = 64.7 bits (156), Expect = 5e-10
Identities = 127/616 (20%), Positives = 229/616 (37%), Gaps = 92/616 (14%)
Query: 270 RLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLA---- 325
RL+ + + VL + L+ VY+ R T + + A L V
Sbjct: 1339 RLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRD 1398
Query: 326 ---PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW------LKNGRKIHSNGRIKMY 376
PPS + R R+ + ++G+ SP + L +GR + +
Sbjct: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGL-SPVRYYTIQTRELPSGRWALHSASVSHN 1457
Query: 377 NSKLVINQIIPEDDAIYQCMAENSQG----SILSRARLTVVMSEDRPSAPYNVHAETMSS 432
S +++++ P ++ A N G S S + T+ + D AP + ++
Sbjct: 1458 ASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE--APTILSVTPHTT 1515
Query: 433 SAILLAWERPLYNSDKV----IAYSVHYMKA----------EGLNNE-----------EY 467
+++L+ W+ P DK+ + + + Y + G+NN
Sbjct: 1516 TSVLIRWQPPA--EDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSM 1573
Query: 468 QVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLT 526
+ + T Y +D+L Y + Y +G S E VP P + +
Sbjct: 1574 RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVH 1633
Query: 527 SRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSI--QVLELPGTTHEYLLEGLKPD 584
+ T + ++W P P + G + Y++ F + ++ +V L + L+ L
Sbjct: 1634 GATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY 1693
Query: 585 SVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPE-LHLEPLNCTTISVRWQQDVE 643
+ Y+V + A G G S T +T +A AP +P + L T+++V W+
Sbjct: 1694 TAYMVSVAAFNAAGDGPRSTPTQGQTQQA----APSAPSSVKFSELTTTSVNVSWEAPQF 1749
Query: 644 DTAAIQGYKLYYKE----EGQQE--------NGPIFLDTKDLLYTLSGLDPRRKYHVRLL 691
++GY+L Y+ +G + N P++L KDL G+ R + +
Sbjct: 1750 PNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDL---AEGVTYRFRIRAKTF 1806
Query: 692 AYNNIDDGYQADQTVST-PGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAA 750
Y G + + V+T PG P P + SS+I +HW
Sbjct: 1807 TY-----GPEIEANVTTGPG---------EGAPGPPGVPIIVRYSSAIAIHWSSGDPGKG 1852
Query: 751 QIINYTIRCNP--VGLQNASLV-LYLQTSETHMLVQGLEPNTKYEFAVRLHVDQ-LSSPW 806
I Y I P GL + + + + S + L+P Y+F V D +P
Sbjct: 1853 PITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPS 1912
Query: 807 SPVVYHSTLPEAPAGP 822
SP ++P A P
Sbjct: 1913 SP---SQSVPAQKANP 1925
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 177 bits (448), Expect = 7e-44
Identities = 229/921 (24%), Positives = 385/921 (41%), Gaps = 92/921 (9%)
Query: 41 FVKEPQD-VTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMS--ENKRIEVLSNGSLYISE 97
F EP+ ++ ++ V + CQA G + W K+ +S +N R +VL++G L I +
Sbjct: 388 FTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQK 447
Query: 98 VEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACK 157
+ D G +QC A N+ G I + + F +P+ T V +G A C+
Sbjct: 448 LR-----PEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502
Query: 158 ISSHPPAVITWEFNRTTL---PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
+S P ITW+ L + + R L +G LQI V +D+GNY C A A+
Sbjct: 503 VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYA---ANTE 559
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS-RLDH 273
S+ AS T+ + H P + T +LH C AT +P+ + + + D+
Sbjct: 560 GSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLH------CGATHDPRVSLRYVWKKDN 613
Query: 274 KSIDVFNTR---VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVL--APPS 328
++ +T V +G+L+IS G Y C + G + +A + L +P +
Sbjct: 614 VALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQN 673
Query: 329 FVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYN-----SKLVIN 383
+ P S + A +V +G SP + ++ + +S ++ + N + + ++
Sbjct: 674 LLVSPNS-SHSHAVVLSWVRPFDG-NSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVS 731
Query: 384 QIIPEDDAIYQCMAENSQG-SILSRARLTVVMSEDRPSA-PYNVHAETMSSSAILLAWER 441
+ P ++ A N G S +++ E+ PSA P N+ A ++ +I++ W+
Sbjct: 732 GLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQP 791
Query: 442 P--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHY-IIDDLEPASNYTFYIVAYMP 498
P ++ + Y + Y A GL E Q I + +Y ++ DL + Y + AY
Sbjct: 792 PPETEHNGVLRGYILRYRLA-GLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNG 850
Query: 499 MGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYR-LSF 556
G S VT+ TL+ VP PP+ + + + T I W P P ++ G Y+ L++
Sbjct: 851 AGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAW 910
Query: 557 RLSTENSIQVLELPGT---THEYLLEGLKPDSVYLVRITAATRVGLGESS----VWTSHR 609
++ V+ + H + LK + Y + T G G S VWT
Sbjct: 911 PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQED 970
Query: 610 TPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIF-L 668
P A L + T++ V WQ+ +E I GY++ ++ G+ ++ L
Sbjct: 971 KPGAVG-------HLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTL 1023
Query: 669 DTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPP--PPPPH 726
++ Y + GL Y + + A + G T+S+ VPP P P
Sbjct: 1024 NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSG---------VPPDLPGAPS 1074
Query: 727 HLYAKANTSSSIFLHWRRPAFTAAQIINYTI---RCNPVGLQNASLVLYLQTSE--THML 781
+L + S L + RP + I+ I + +G + + LY + +E ML
Sbjct: 1075 NLVISNISPRSATLQF-RPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQML 1133
Query: 782 -VQGLEPNTKYEFAVRLHVDQLSSPWSPVV-YHSTLPEAPAGPPVGVKVTLIEDDTALVS 839
+ L P T Y F ++ SP+SP TL P P V V + + +
Sbjct: 1134 EIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLR 1193
Query: 840 WKP-PD-----GPETVVTRYTILYASRKAWIAGEWQV----LHREGAITMALLENLVAGN 889
W P PD PE+V Y I Y + QV L RE I E L
Sbjct: 1194 WVPLPDSQYNGNPESV--GYRIKYWRSDLQSSAVAQVVSDRLEREFTI-----EELEEWM 1246
Query: 890 VYIVKISASNEVGEGPFSNSV 910
Y +++ A N VG GP+S V
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVV 1267
Score = 146 bits (369), Expect = 1e-34
Identities = 197/823 (23%), Positives = 321/823 (39%), Gaps = 86/823 (10%)
Query: 56 VVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLA 115
+VL C A G P++ W+++ ++++ S+ YI ++ D GFY+C+
Sbjct: 122 LVLTCLAEGSWPLEFKWMRDDSELT------TYSSEYKYIIPSL----QKLDAGFYRCVV 171
Query: 116 MNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARF-ACKISSHPPAVITWEFNRTT 174
N+ GA+L +K+ + ++ + +F V +G A I+S+P +TW F
Sbjct: 172 RNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTW-FREGH 230
Query: 175 LPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHT 234
+ +RI L I + D+G Y A + + + A++ + T
Sbjct: 231 KIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPET 290
Query: 235 --PTIIAGPQNITTSLHQT-VVLECMATGNPKPIIS--WSRLDHKSIDVFNTRVLGNGNL 289
PTI+ P N + + LEC+A+ P +S W R + + + L
Sbjct: 291 MAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKR---NGVRITSGLHSFGRRL 347
Query: 290 MISDVRLQHAGVYVCRATTPGTRNFTVAMAT--LTVLAPPSFVEWPES-LTRPRAGTARF 346
IS+ G YVC A PG+ F A AT L ++ PP F PES ++ T
Sbjct: 348 TISNPTSADTGPYVCEAALPGSA-FEPARATAFLFIIEPPYFTAEPESRISAEVEETVDI 406
Query: 347 VCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNS-KLVINQIIPEDDAIYQCMAENSQGS 403
CQA G+P P + W K+ I N R K+ S L I ++ PED I+QC A N G
Sbjct: 407 GCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGE 466
Query: 404 ILSRARLTVV----MSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKA 459
I + L V + RP V +L E + +++ A
Sbjct: 467 IQTHTYLDVTNIAPVFTQRP-----VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILA 521
Query: 460 EGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLR 519
G +++ + ++ A NYT Y A G+ S +T + +
Sbjct: 522 SGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCY--AANTEGSLNASATLTVWNRTSI-VH 578
Query: 520 PPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLE 579
PPE + + T A G R+S R + V P +T ++E
Sbjct: 579 PPEDHVVIKGTT----------ATLHCGATHDPRVSLRYVWKKD-NVALTPSSTSRIVVE 627
Query: 580 GLKPDSVYLVRITAATRVGLGESSV----WTSHRTPKATSVKAPKSPELHLEPLNCT--- 632
D L+ T + +G + R + ++ P SP+ L N +
Sbjct: 628 ---KDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSH 684
Query: 633 TISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPIFLDTKDL-----LYTLSGLDPRRKYH 687
+ + W + + + I LYY E + N P + ++ T+SGL P R Y
Sbjct: 685 AVVLSWVRPFDGNSPI----LYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQ 740
Query: 688 VRLLAYNNIDDGYQADQTVSTPGCVSVRDRMV----PPPPPPHHLYAKANTSSSIFLHWR 743
R+ A N + G + +T R++ PP PP ++ A T+ SI + W+
Sbjct: 741 FRVCAVNEVGRGQYSAET----------SRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQ 790
Query: 744 RPAFTA--AQIINYTIRCNPVGLQNASLVLYLQTSE-THMLVQGLEPNTKYEFAVRLHVD 800
P T + Y +R GL + + E + LV L T+YE V +
Sbjct: 791 PPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNG 850
Query: 801 QLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPP 843
+S V TL P PP V+ + T W PP
Sbjct: 851 AGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPP 893
Score = 116 bits (290), Expect = 1e-25
Identities = 138/540 (25%), Positives = 224/540 (41%), Gaps = 65/540 (12%)
Query: 421 APYNVHAETMSSSAILLAWERPL----YNSD-KVIAYSVHYMKAEGLNNEEYQVVIGNDT 475
AP +V T S +++ L W PL YN + + + Y + Y +++ ++ QVV
Sbjct: 1176 APTSVTVRTASETSLRLRWV-PLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLE 1234
Query: 476 THYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE-ISLTSRSPTDIL 534
+ I++LE Y + A+ +GA S+ V T E VP PE +S + S T IL
Sbjct: 1235 REFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQIL 1294
Query: 535 ISWLPIPAKYRRGQVVLYRLSFR---LSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRI 591
++W +P + + G ++ Y++ FR L E ++ T LL GL+ +Y +++
Sbjct: 1295 LTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR-GNHTQSALLAGLRKFVLYELQV 1353
Query: 592 TAATRVGLGESSVWTSHRTP---KATSVKAPKSP-ELHLEPLNCTTISVRWQQDVEDTAA 647
A TR+G G S TP + T AP P L + T++ + WQ E
Sbjct: 1354 LAFTRIGNGVPS------TPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGI 1407
Query: 648 IQGYKLYYKEEGQQENGPIFLDTKDL-----LYTLSGLDPRRKYHVRLLAYNNIDDGYQA 702
I GY++ Y+ + P T ++ +T + L P Y RL A G
Sbjct: 1408 ILGYQIAYR---LASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL 1464
Query: 703 DQTVSTPGCVSVRDRMVPPPPPPHHLYAKAN-TSSSIFLHWRRPAFTAAQIINYTIRCNP 761
+ TV T R+R P PP L +A T+ S+ L W + A+ I +T++
Sbjct: 1465 EATVIT---TEKRER---PAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRE 1518
Query: 762 VGLQNASLVLY---LQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH-STLPE 817
L Y + T +V L P T Y+ ++ D S +S +TL +
Sbjct: 1519 --LPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQD 1576
Query: 818 APAGPPVGVKVTLIEDDTALVSWKPP--DGPETVVTRYTILYAS---------------- 859
P PP V T + L+ W+PP + ++ Y I Y
Sbjct: 1577 VPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKN 1636
Query: 860 -----RKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAV 914
+ ++ ++ TM L +L Y V ++A N +GE P S VE+ V
Sbjct: 1637 PIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFV 1696
Score = 113 bits (283), Expect = 9e-25
Identities = 125/528 (23%), Positives = 220/528 (41%), Gaps = 53/528 (10%)
Query: 420 SAPYNVHAETMSSSAILLAWER-PLYNSDKVIAYSVHYMKAEGLNNE-EYQVVIGNDTTH 477
+AP NV AE +SS+ ILL W P + + +I +A+ L+ E +V GN T
Sbjct: 1278 AAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQS 1337
Query: 478 YIIDDLEPASNYTFYIVAYMPMGASQMSDH-VTQNTLEDVPLRPPEISLTSRSPTDILIS 536
++ L Y ++A+ +G S + + T +D P P + T + I
Sbjct: 1338 ALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIV 1397
Query: 537 WLPIPAKYRRGQVVLYRLSFRL--STENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAA 594
W P + G ++ Y++++RL S+ ++ +E+ T ++ L P+S Y+ R++A
Sbjct: 1398 WQP--PEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAK 1455
Query: 595 TRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLY 654
TR G GE T T K P+ + + ++ ++W + + I+ + +
Sbjct: 1456 TRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQ 1515
Query: 655 YKE--EGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCV 712
+E G+ + + + + L P Y +RL A N+I D +D + T
Sbjct: 1516 VRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGD---SDFSSETEAVT 1572
Query: 713 SVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPA-------------------FTAAQII 753
+++D P PP + A +T+SS+ + W+ P + A
Sbjct: 1573 TLQD---VPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGT 1629
Query: 754 NYTIRCNPVGL------QNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWS 807
NP+ L Q++ + ++ T + L+ +YE + + SP S
Sbjct: 1630 EAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPAS 1689
Query: 808 PVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETV---VTRYTILYASRKAWI 864
V APA P V+VT + V+W PP PE+ + Y I Y W
Sbjct: 1690 APVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPP-PESQNGNIQGYKIYY-----WE 1743
Query: 865 AGEWQVLHREGAITM----ALLENLVAGNVYIVKISASNEVGEGPFSN 908
A + + + L+NL + Y+V ISA N G+GP S+
Sbjct: 1744 ADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSD 1791
Score = 70.5 bits (171), Expect = 9e-12
Identities = 102/484 (21%), Positives = 182/484 (37%), Gaps = 61/484 (12%)
Query: 416 EDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDT 475
+D P P + + +++ + W+ P + ++ Y + Y A + V +G
Sbjct: 1375 DDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATV 1434
Query: 476 THYIIDDLEPASNYTFYIVAYM------PMGASQMSDHVTQNTLEDVPLRPPEISLTSRS 529
+ DL P S Y F + A P+ A+ ++ + L P+ +T+RS
Sbjct: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARS 1494
Query: 530 PTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHE---YLLEGLKPDSV 586
+ + W +P + + + R Q +HE +++ L+P +
Sbjct: 1495 ---LRLQW--VPGSDGASPIRYFTMQVRELPRGEWQTYS-SSISHEATACVVDRLRPFTS 1548
Query: 587 YLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSP--ELHLEPLNCTTISVRWQ--QDV 642
Y +R+ A +G S ++S T P P + P +++ ++WQ +D
Sbjct: 1549 YKLRLKATNDIG---DSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDE 1605
Query: 643 EDTAAIQGYKLYYKE---------EGQQENGPIFL---------------DTKDLLYTLS 678
+QGY++YY+E E + PI L + + L+
Sbjct: 1606 SLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELT 1665
Query: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSI 738
L R+Y V + AYN I + S P V V + P P ++ T+S +
Sbjct: 1666 HLKKYRRYEVIMTAYNII-----GESPASAPVEVFVGE--AAPAMAPQNVQVTPLTASQL 1718
Query: 739 FLHWRRPAFTA--AQIINYTIRCNPVGLQNAS---LVLYLQTSETHMLVQGLEPNTKYEF 793
+ W P + I Y I QN + VL+L E + ++ L +TKY
Sbjct: 1719 EVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFL--PEPVVRLKNLTSHTKYLV 1776
Query: 794 AVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRY 853
++ P S T AP G P + + I T VSW P ++ Y
Sbjct: 1777 SISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSEITSTTLNVSWGEPAAANGILQGY 1835
Query: 854 TILY 857
++Y
Sbjct: 1836 RVVY 1839
Score = 59.3 bits (142), Expect = 2e-08
Identities = 85/371 (22%), Positives = 154/371 (41%), Gaps = 47/371 (12%)
Query: 325 APPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKL---- 380
APP + P++ R+ ++V ++G SP + R++ G + Y+S +
Sbjct: 1478 APPRELLVPQAEVTARSLRLQWVPGSDGA-SPIRYFTMQVREL-PRGEWQTYSSSISHEA 1535
Query: 381 ---VINQIIPEDDAIYQCMAENSQG-SILSRARLTVVMSEDRPSAPY-NVHAETMSSSAI 435
V++++ P + A N G S S V +D P P +V A ++S++
Sbjct: 1536 TACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSV 1595
Query: 436 LLAWERPLYNSDKVI--AYSVHY---------------------MKAEGLNNEEYQVVIG 472
L+ W+ P S + Y ++Y + AE ++ V
Sbjct: 1596 LIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNS 1655
Query: 473 NDT-THYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVP-LRPPEISLTSRSP 530
+ T T + L+ Y + AY +G S S V E P + P + +T +
Sbjct: 1656 SSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTA 1715
Query: 531 TDILISWLPIPAKYRRGQVVLYRLSF-RLSTENS---IQVLELPGTTHEYLLEGLKPDSV 586
+ + ++W P P + + G + Y++ + ++N ++VL LP L+ L +
Sbjct: 1716 SQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVR--LKNLTSHTK 1773
Query: 587 YLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPE-LHLEPLNCTTISVRWQQDVEDT 645
YLV I+A G G S RT +A AP +P L + TT++V W +
Sbjct: 1774 YLVSISAFNAAGDGPKSDPQQGRTHQA----APGAPSFLAFSEITSTTLNVSWGEPAAAN 1829
Query: 646 AAIQGYKLYYK 656
+QGY++ Y+
Sbjct: 1830 GILQGYRVVYE 1840
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 172 bits (435), Expect = 2e-42
Identities = 195/759 (25%), Positives = 302/759 (39%), Gaps = 84/759 (11%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P DV V++ +P L+C+A G + W K+G ++ +K +L +GSL+
Sbjct: 50 VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFL 109
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S+ A L ++ + F P V G A
Sbjct: 110 RIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILE 169
Query: 156 CKIS-SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I W+ ++ + +RI+ + G L I + + D+G Y C+ + R
Sbjct: 170 CQPPRGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGER 228
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
S A LTV F PT + P N + V C G+P+P + W + D
Sbjct: 229 DSDPAELTV--------FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK-DDA 279
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPE 334
+ + + L I G Y+C A + A ATLTV APP FV P
Sbjct: 280 DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK--MEASATLTVRAPPQFVVRPR 337
Query: 335 SLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKMY-NSKLVINQI 385
+ T F C+ +G P P + W K G + N R + L I I
Sbjct: 338 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 397
Query: 386 IPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAETMSSSAILLAW 439
D Y C A GSIL++A+L V + DRP P N +T++ L
Sbjct: 398 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN---QTLAVDGTALLK 454
Query: 440 ERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPM 499
+ + VI++ G + + I T I +L + T+ VA
Sbjct: 455 CKATGDPLPVISWLKEGFTFPG---RDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSS 510
Query: 500 GASQMSD--HVTQN--------TLEDVPLRPPEISLTSRSPTDILISWLP-IPAKYRRGQ 548
G + S VT++ L D+P P + +T + + +SW P P
Sbjct: 511 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 570
Query: 549 VVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS----- 603
++ +F S NS Q + T Y + GL+P+++YL + A GL + S
Sbjct: 571 YIIE--AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 628
Query: 604 VWTSHRTPKATSVKAPKSPE--------LHLE-PLNCTTISVRWQQDVEDTAAIQGYKLY 654
V T +P A V + + LH L TT+ V W D IQGY++
Sbjct: 629 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD-RQPQFIQGYRVM 687
Query: 655 YKEEG--QQENGPIFLDTK---DLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTP 709
Y++ Q + LD K + L L Y +++ Y N G ++
Sbjct: 688 YRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK---- 743
Query: 710 GCVSVRDRMVPPPPPPHH---LYAKANTSSSIFLHWRRP 745
+VR P PP L + S+SI + W P
Sbjct: 744 ---TVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPP 779
Score = 169 bits (428), Expect = 1e-41
Identities = 189/777 (24%), Positives = 300/777 (38%), Gaps = 100/777 (12%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQA-HGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P +L+CQ G + W K+ ++ + + + G L IS
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 210
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S A L + F +PI+ V E F C++
Sbjct: 211 -----KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 265
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W+ + LP R L+I D G Y CIA +R MEA
Sbjct: 266 GDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAE---NRVGKMEA 320
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
S T+ P + P++ + +TV C GNP+P + W + +++
Sbjct: 321 SATLTVRAP------PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 374
Query: 280 NT--------RVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA----TLTVLAPP 327
N V G+L I++++ AG Y+C+A T A LT PP
Sbjct: 375 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 434
Query: 328 SFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG---------RKIHSNGRIKMYNS 378
++ P + T GTA C+A G P P +SWLK G I G +++ N
Sbjct: 435 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNL 494
Query: 379 KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMS----------EDRPSAPYNVHAE 428
++ D Y C+A +S G A L V S D P P
Sbjct: 495 RI-------SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT 547
Query: 429 TMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASN 488
++ +++ L+W+ + AY + ++ ++N V TT Y + L P +
Sbjct: 548 DVTKNSVTLSWQPGTPGTLPASAYIIEAF-SQSVSNSWQTVANHVKTTLYTVRGLRPNTI 606
Query: 489 YTFYIVAYMPMGASQ---MSDHV----------------TQNTLEDVPLR-PPEISLTSR 528
Y F + A P G S MSD V Q L DV +R + LT
Sbjct: 607 YLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLT-- 664
Query: 529 SPTDILISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLELP-GTTHEYLLEGLKPDSV 586
PT + ++W + ++ +G V+YR + L +S Q L+ T +L LK
Sbjct: 665 -PTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVT 723
Query: 587 YLVRITAATRVGLG-ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVED- 644
Y +++ G +S T T +A S L + N T+ISV W D
Sbjct: 724 YEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDH 783
Query: 645 -TAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
IQ YK++ + + +D + GL P +Y V + A + G +++
Sbjct: 784 QNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 843
Query: 704 ----------QTVSTPGCVSVRDRMVPPPPPPHHLYAKANT------SSSIFLHWRR 744
+ V T S+ +++ P + SI+L+WRR
Sbjct: 844 PQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRR 900
Score = 121 bits (303), Expect = 4e-27
Identities = 141/623 (22%), Positives = 247/623 (39%), Gaps = 73/623 (11%)
Query: 36 FSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYI 95
F +F++ P + V ++ V CQ G+ V W K+ A + R ++ + +L I
Sbjct: 238 FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG-RYDIKDDYTLRI 296
Query: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFA 155
++ +DEG Y C+A N+ G + A L + F V+P V +G F
Sbjct: 297 -----KKTMSTDEGTYMCIAENRVGK-MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP 350
Query: 156 CKISSHPPAVITWEF---------NRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCI 206
C+ +P + W+ N+ P + R + PTG L I ++ + D+G Y C
Sbjct: 351 CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS--RCSVSPTGDLTITNIQRSDAGYYICQ 408
Query: 207 AATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPII 266
A TVA + +A L V + P I+ GP N T ++ T +L+C ATG+P P+I
Sbjct: 409 ALTVAGSILA-KAQLEVTDVLTDRP--PPIILQGPANQTLAVDGTALLKCKATGDPLPVI 465
Query: 267 SWSR--LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-- 322
SW + D T + G L I ++R+ G Y C AT+ A+ +T
Sbjct: 466 SWLKEGFTFPGRDPRAT-IQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES 524
Query: 323 ------------VLAPPSFVEWPE------SLTRPRAGTARFVCQAEGIPSPKMSWLKNG 364
+ PPS + + +L+ A I + S +
Sbjct: 525 GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW 584
Query: 365 RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSED-RPSAPY 423
+ + ++ + +Y + + P ++ A N QG V ++D P A
Sbjct: 585 QTVANHVKTTLY----TVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQG 640
Query: 424 NVHAETMSS-SAILLAWERPLYNSDKVI--------------AYSVHYMKAEGLN-NEEY 467
H + +L+ P+ + + Y V Y + GL +
Sbjct: 641 VDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSW 700
Query: 468 QVVIGNDTTH--YIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE--- 522
Q + T ++ +L+ Y + Y S+ T T E+ P PP+
Sbjct: 701 QNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVT 760
Query: 523 -ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLE-LPGTTHEYLLEG 580
+++ S + T I +SW P P ++ G + Y++ + L E + + + ++ G
Sbjct: 761 VLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINKTVDAAIRSVIIGG 819
Query: 581 LKPDSVYLVRITAATRVGLGESS 603
L P Y V + A+T G+G S
Sbjct: 820 LFPGIQYRVEVAASTSAGVGVKS 842
Score = 52.0 bits (123), Expect = 3e-06
Identities = 94/407 (23%), Positives = 142/407 (34%), Gaps = 69/407 (16%)
Query: 619 PKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLY-YKEEGQQENGPIFLDTKDLLYTL 677
P P++ N T+S WQ T Y + + + + K LYT+
Sbjct: 541 PSKPQVTDVTKNSVTLS--WQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTV 598
Query: 678 SGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVS--VRDRMVPPPPP--PHHLYAKAN 733
GL P Y + A N Q +S P +S VR + + PP H K
Sbjct: 599 RGLRPNTIYLFMVRAIN--------PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKEL 650
Query: 734 TSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTS----------------- 776
+ LH + +T+ P +Q V+Y QTS
Sbjct: 651 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYR-VMYRQTSGLQATSSWQNLDAKVPT 709
Query: 777 ETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLI---ED 833
E ++ L+ YE VR + ++ S T EAP+ PP V V +
Sbjct: 710 ERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNS 769
Query: 834 DTALVSW--KPPDGPETVVTRYTILYASRKAWIAGEWQVLH----REGAITMALLENLVA 887
+ VSW PPD ++ Y K W G H + AI ++ L
Sbjct: 770 TSISVSWDPPPPDHQNGIIQEY-------KIWCLGNETRFHINKTVDAAIRSVIIGGLFP 822
Query: 888 GNVYIVKISASNEVGEGPFSNSVELAVLPKE----TSESNQRPKRLDSADAKVYSGYYHL 943
G Y V+++AS G G S + + + T +N +++
Sbjct: 823 GIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQI-------------T 869
Query: 944 DQKSMTGIAVGVGIALTCILICVLILIY-RSKARK--SSASKTAQNG 987
D G+G A IL+ I +Y R K RK S+ + T Q G
Sbjct: 870 DVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRG 916
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 24/186 (12%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106
Query: 290 MISDVRLQHA-------GVYVCRATT----PGTRNFTVAMATLTVLAPPSFVEWPESLTR 338
+R+ H G YVC A +RN ++ +A L F + P +
Sbjct: 107 FF--LRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR----DDFRQNPTDVVV 160
Query: 339 PRAGTARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCM 396
A CQ G P P + W K+ +I RI + KL+I+ D +Y C+
Sbjct: 161 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 220
Query: 397 AENSQG 402
N G
Sbjct: 221 GTNMVG 226
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P + + C+AEG P+P + W K+G ++ + + R+ + +
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILSR-ARLTVVMSED 417
L +I+ D+ Y C+A N G +SR A L V + D
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD 149
Score = 32.3 bits (72), Expect = 2.7
Identities = 19/82 (23%), Positives = 35/82 (42%), Gaps = 2/82 (2%)
Query: 821 GPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMA 880
GPP +VT + ++ +SW+P + Y I S+ ++ WQ + T+
Sbjct: 539 GPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQS--VSNSWQTVANHVKTTLY 596
Query: 881 LLENLVAGNVYIVKISASNEVG 902
+ L +Y+ + A N G
Sbjct: 597 TVRGLRPNTIYLFMVRAINPQG 618
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 172 bits (435), Expect = 2e-42
Identities = 195/759 (25%), Positives = 302/759 (39%), Gaps = 84/759 (11%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P DV V++ +P L+C+A G + W K+G ++ +K +L +GSL+
Sbjct: 34 VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFL 93
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S+ A L ++ + F P V G A
Sbjct: 94 RIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILE 153
Query: 156 CKIS-SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I W+ ++ + +RI+ + G L I + + D+G Y C+ + R
Sbjct: 154 CQPPRGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGER 212
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
S A LTV F PT + P N + V C G+P+P + W + D
Sbjct: 213 DSDPAELTV--------FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK-DDA 263
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPE 334
+ + + L I G Y+C A + A ATLTV APP FV P
Sbjct: 264 DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK--MEASATLTVRAPPQFVVRPR 321
Query: 335 SLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKMY-NSKLVINQI 385
+ T F C+ +G P P + W K G + N R + L I I
Sbjct: 322 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 381
Query: 386 IPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAETMSSSAILLAW 439
D Y C A GSIL++A+L V + DRP P N +T++ L
Sbjct: 382 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPAN---QTLAVDGTALLK 438
Query: 440 ERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPM 499
+ + VI++ G + + I T I +L + T+ VA
Sbjct: 439 CKATGDPLPVISWLKEGFTFPG---RDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSS 494
Query: 500 GASQMSD--HVTQN--------TLEDVPLRPPEISLTSRSPTDILISWLP-IPAKYRRGQ 548
G + S VT++ L D+P P + +T + + +SW P P
Sbjct: 495 GETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASA 554
Query: 549 VVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS----- 603
++ +F S NS Q + T Y + GL+P+++YL + A GL + S
Sbjct: 555 YIIE--AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP 612
Query: 604 VWTSHRTPKATSVKAPKSPE--------LHLE-PLNCTTISVRWQQDVEDTAAIQGYKLY 654
V T +P A V + + LH L TT+ V W D IQGY++
Sbjct: 613 VRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVD-RQPQFIQGYRVM 671
Query: 655 YKEEG--QQENGPIFLDTK---DLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTP 709
Y++ Q + LD K + L L Y +++ Y N G ++
Sbjct: 672 YRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESK---- 727
Query: 710 GCVSVRDRMVPPPPPPHH---LYAKANTSSSIFLHWRRP 745
+VR P PP L + S+SI + W P
Sbjct: 728 ---TVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPP 763
Score = 169 bits (428), Expect = 1e-41
Identities = 189/777 (24%), Positives = 300/777 (38%), Gaps = 100/777 (12%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQA-HGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P +L+CQ G + W K+ ++ + + + G L IS
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 194
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S A L + F +PI+ V E F C++
Sbjct: 195 -----KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 249
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W+ + LP R L+I D G Y CIA +R MEA
Sbjct: 250 GDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAE---NRVGKMEA 304
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
S T+ P + P++ + +TV C GNP+P + W + +++
Sbjct: 305 SATLTVRAP------PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFP 358
Query: 280 NT--------RVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA----TLTVLAPP 327
N V G+L I++++ AG Y+C+A T A LT PP
Sbjct: 359 NQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPP 418
Query: 328 SFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG---------RKIHSNGRIKMYNS 378
++ P + T GTA C+A G P P +SWLK G I G +++ N
Sbjct: 419 IILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNL 478
Query: 379 KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMS----------EDRPSAPYNVHAE 428
++ D Y C+A +S G A L V S D P P
Sbjct: 479 RI-------SDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT 531
Query: 429 TMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASN 488
++ +++ L+W+ + AY + ++ ++N V TT Y + L P +
Sbjct: 532 DVTKNSVTLSWQPGTPGTLPASAYIIEAF-SQSVSNSWQTVANHVKTTLYTVRGLRPNTI 590
Query: 489 YTFYIVAYMPMGASQ---MSDHV----------------TQNTLEDVPLR-PPEISLTSR 528
Y F + A P G S MSD V Q L DV +R + LT
Sbjct: 591 YLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLT-- 648
Query: 529 SPTDILISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLELP-GTTHEYLLEGLKPDSV 586
PT + ++W + ++ +G V+YR + L +S Q L+ T +L LK
Sbjct: 649 -PTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVT 707
Query: 587 YLVRITAATRVGLG-ESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVED- 644
Y +++ G +S T T +A S L + N T+ISV W D
Sbjct: 708 YEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDH 767
Query: 645 -TAAIQGYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
IQ YK++ + + +D + GL P +Y V + A + G +++
Sbjct: 768 QNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
Query: 704 ----------QTVSTPGCVSVRDRMVPPPPPPHHLYAKANT------SSSIFLHWRR 744
+ V T S+ +++ P + SI+L+WRR
Sbjct: 828 PQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRR 884
Score = 121 bits (303), Expect = 4e-27
Identities = 141/623 (22%), Positives = 247/623 (39%), Gaps = 73/623 (11%)
Query: 36 FSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYI 95
F +F++ P + V ++ V CQ G+ V W K+ A + R ++ + +L I
Sbjct: 222 FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRG-RYDIKDDYTLRI 280
Query: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFA 155
++ +DEG Y C+A N+ G + A L + F V+P V +G F
Sbjct: 281 -----KKTMSTDEGTYMCIAENRVGK-MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFP 334
Query: 156 CKISSHPPAVITWEF---------NRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCI 206
C+ +P + W+ N+ P + R + PTG L I ++ + D+G Y C
Sbjct: 335 CETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS--RCSVSPTGDLTITNIQRSDAGYYICQ 392
Query: 207 AATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPII 266
A TVA + +A L V + P I+ GP N T ++ T +L+C ATG+P P+I
Sbjct: 393 ALTVAGSILA-KAQLEVTDVLTDRP--PPIILQGPANQTLAVDGTALLKCKATGDPLPVI 449
Query: 267 SWSR--LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-- 322
SW + D T + G L I ++R+ G Y C AT+ A+ +T
Sbjct: 450 SWLKEGFTFPGRDPRAT-IQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES 508
Query: 323 ------------VLAPPSFVEWPE------SLTRPRAGTARFVCQAEGIPSPKMSWLKNG 364
+ PPS + + +L+ A I + S +
Sbjct: 509 GATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSW 568
Query: 365 RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSED-RPSAPY 423
+ + ++ + +Y + + P ++ A N QG V ++D P A
Sbjct: 569 QTVANHVKTTLY----TVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQG 624
Query: 424 NVHAETMSS-SAILLAWERPLYNSDKVI--------------AYSVHYMKAEGLN-NEEY 467
H + +L+ P+ + + Y V Y + GL +
Sbjct: 625 VDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSW 684
Query: 468 QVVIGNDTTH--YIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE--- 522
Q + T ++ +L+ Y + Y S+ T T E+ P PP+
Sbjct: 685 QNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVT 744
Query: 523 -ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLE-LPGTTHEYLLEG 580
+++ S + T I +SW P P ++ G + Y++ + L E + + + ++ G
Sbjct: 745 VLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI-WCLGNETRFHINKTVDAAIRSVIIGG 803
Query: 581 LKPDSVYLVRITAATRVGLGESS 603
L P Y V + A+T G+G S
Sbjct: 804 LFPGIQYRVEVAASTSAGVGVKS 826
Score = 52.0 bits (123), Expect = 3e-06
Identities = 94/407 (23%), Positives = 142/407 (34%), Gaps = 69/407 (16%)
Query: 619 PKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLY-YKEEGQQENGPIFLDTKDLLYTL 677
P P++ N T+S WQ T Y + + + + K LYT+
Sbjct: 525 PSKPQVTDVTKNSVTLS--WQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTV 582
Query: 678 SGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVS--VRDRMVPPPPP--PHHLYAKAN 733
GL P Y + A N Q +S P +S VR + + PP H K
Sbjct: 583 RGLRPNTIYLFMVRAIN--------PQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKEL 634
Query: 734 TSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTS----------------- 776
+ LH + +T+ P +Q V+Y QTS
Sbjct: 635 GDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYR-VMYRQTSGLQATSSWQNLDAKVPT 693
Query: 777 ETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLI---ED 833
E ++ L+ YE VR + ++ S T EAP+ PP V V +
Sbjct: 694 ERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNS 753
Query: 834 DTALVSW--KPPDGPETVVTRYTILYASRKAWIAGEWQVLH----REGAITMALLENLVA 887
+ VSW PPD ++ Y K W G H + AI ++ L
Sbjct: 754 TSISVSWDPPPPDHQNGIIQEY-------KIWCLGNETRFHINKTVDAAIRSVIIGGLFP 806
Query: 888 GNVYIVKISASNEVGEGPFSNSVELAVLPKE----TSESNQRPKRLDSADAKVYSGYYHL 943
G Y V+++AS G G S + + + T +N +++
Sbjct: 807 GIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQI-------------T 853
Query: 944 DQKSMTGIAVGVGIALTCILICVLILIY-RSKARK--SSASKTAQNG 987
D G+G A IL+ I +Y R K RK S+ + T Q G
Sbjct: 854 DVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRG 900
Score = 49.7 bits (117), Expect = 2e-05
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 24/186 (12%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90
Query: 290 MISDVRLQHA-------GVYVCRATT----PGTRNFTVAMATLTVLAPPSFVEWPESLTR 338
+R+ H G YVC A +RN ++ +A L F + P +
Sbjct: 91 FF--LRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLR----DDFRQNPTDVVV 144
Query: 339 PRAGTARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCM 396
A CQ G P P + W K+ +I RI + KL+I+ D +Y C+
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
Query: 397 AENSQG 402
N G
Sbjct: 205 GTNMVG 210
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/104 (27%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P + + C+AEG P+P + W K+G ++ + + R+ + +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILSR-ARLTVVMSED 417
L +I+ D+ Y C+A N G +SR A L V + D
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD 133
Score = 32.3 bits (72), Expect = 2.7
Identities = 19/82 (23%), Positives = 35/82 (42%), Gaps = 2/82 (2%)
Query: 821 GPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMA 880
GPP +VT + ++ +SW+P + Y I S+ ++ WQ + T+
Sbjct: 523 GPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQS--VSNSWQTVANHVKTTLY 580
Query: 881 LLENLVAGNVYIVKISASNEVG 902
+ L +Y+ + A N G
Sbjct: 581 TVRGLRPNTIYLFMVRAINPQG 602
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 171 bits (433), Expect = 4e-42
Identities = 210/922 (22%), Positives = 347/922 (37%), Gaps = 58/922 (6%)
Query: 41 FVKEPQDVTV---TRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEV-LSNGSLYIS 96
F++EP V + + V L+C+ G + W NG + + GSL I+
Sbjct: 28 FIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLIN 87
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPIST-EVHEGGVARFA 155
+ D G YQC A N +G I+S++A L + + F+ + ST V G
Sbjct: 88 NPN----KTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLL 143
Query: 156 CKISSHPPAV-ITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C H + W FN R + TG L I V + D GNY C+
Sbjct: 144 CGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNH 203
Query: 215 KSMEASLTVIPAKES-KSFHTPTI-IAGPQNITTSLHQTVVLECMATGNPKPIISWSRLD 272
K + +I + + P I + P+ + T+ TV LEC A GNP P I W R D
Sbjct: 204 KVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRAD 263
Query: 273 HKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEW 332
K I R NG L I + + + AG+Y C A +N VA LT A P++++
Sbjct: 264 GKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKN--VARGQLTFYAQPNWIQK 321
Query: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392
+ + C+A G P P WLKNG + + RI++ L I + D +
Sbjct: 322 INDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGM 381
Query: 393 YQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAY 452
YQC+AEN G I S A L+V+ S + ++ +P + V +
Sbjct: 382 YQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 441
Query: 453 SVHYMKAEGLNNEEYQVVIGNDTTHYIID-DLEPASNYTFYIVAYMPMGASQMSDHVTQN 511
K + E ++ I D II+ A +YT +A G + + ++
Sbjct: 442 K----KGRDILKENERITISEDGNLRIINVTKSDAGSYT--CIATNHFGTASSTGNLVVK 495
Query: 512 TLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPG 571
V + P + +T LP + +++ SF + + G
Sbjct: 496 DPTRVMVPPSSMDVTVGESI-----VLPCQVTHDHSLDIVFTWSF----NGHLIDFDRDG 546
Query: 572 TTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATS---VKAPKSP--ELHL 626
H + G ++R G V TS A + V+ P P + +
Sbjct: 547 -DHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTI 605
Query: 627 EPLNCTTISVRWQQDVEDTAAIQGYKLYYK---EEGQQ--ENGPIFLDTKDLLYTLSGLD 681
+ + TT + W+ ++ + I Y + + G Q P +D K T+ GL+
Sbjct: 606 DEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLN 665
Query: 682 PRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLH 741
P +Y R +A N I G + + R P P ++ + S + +
Sbjct: 666 PWVEYEFRTVAANVIGIGEPSRPSEKR------RTEEALPEVTPANVSGGGGSKSELVIT 719
Query: 742 WRR--PAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLV--QGLEPNTKYEFAVRL 797
W + Y + P G L + + + + + P + +E V +
Sbjct: 720 WETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGV 779
Query: 798 HVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPP-DGPETVVTRYTIL 856
++ P+SP + E P PP + + V W P + + Y +
Sbjct: 780 FNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVK 839
Query: 857 YASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLP 916
Y R + + G T + NL +Y + + A N G GP S +V +
Sbjct: 840 Y-WRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRK 898
Query: 917 KETSESNQRPKRL--DSADAKV 936
S Q P + +S+D+K+
Sbjct: 899 PPPS---QPPGNIIWNSSDSKI 917
Score = 131 bits (330), Expect = 3e-30
Identities = 177/710 (24%), Positives = 293/710 (41%), Gaps = 77/710 (10%)
Query: 36 FSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYI 95
+++ +++++ D+ V ++ V +C+A+G WLKNG + RI++ G+L I
Sbjct: 313 YAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI-EQGTLNI 371
Query: 96 SEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPIS--TEVHEGGVAR 153
+ V SD G YQCLA NK+G I S ++ F + T V GG
Sbjct: 372 TIV-----NLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVV 426
Query: 154 FACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHR 213
CK + P V TW+ R L +RIT G L+I +V++ D+G+Y CIA
Sbjct: 427 IECKPKASPKPVYTWKKGRDILKEN-ERITISEDGNLRIINVTKSDAGSYTCIATNHFGT 485
Query: 214 RKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPK--PIISWSRL 271
S + P + ++ P ++ ++ +++VL C T + + +WS
Sbjct: 486 ASSTGNLVVKDPTR---------VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFN 536
Query: 272 DH-----KSIDVFNTRVLGN---GNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTV 323
H + D F RV G G+LMI +++L+HAG YVC T R A A L V
Sbjct: 537 GHLIDFDRDGDHFE-RVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDR--LSAAADLIV 593
Query: 324 LAPPSFVEWPESLTRPRAGTARFVCQAEGIP---SPKMSWLKNGRKIHSNG------RIK 374
PP PE++T P SP ++ R S G +
Sbjct: 594 RGPPG---PPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPE 650
Query: 375 MYNSKLVINQII---PEDDAIYQCMAENSQG----SILSRARLTVVMSEDRPS-APYNVH 426
+ + K ++ P + ++ +A N G S S R T E P P NV
Sbjct: 651 LIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRT---EEALPEVTPANVS 707
Query: 427 AETMSSSAILLAWE---RPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYII--D 481
S S +++ WE L N + Y V + + G V+ D + Y+ +
Sbjct: 708 GGGGSKSELVITWETVPEELQNG-RGFGYVVAF-RPYGKMIWMLTVLASADASRYVFRNE 765
Query: 482 DLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDILISWLPI 540
+ P S + + + G S + E+ P +PP I S S TDI + W
Sbjct: 766 SVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS- 824
Query: 541 PAKYRRGQVVLYRLSF--RLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVG 598
P + RG++ Y + + E + + + G + LK +Y + + A G
Sbjct: 825 PLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAG 884
Query: 599 LGESSVWTSHRTPKATSVKAPKS--PELHLEPLNCTTISVRWQQ--DVEDTAAIQGYKLY 654
G SS T T+ K P S P + + + I + W Q +++ + ++GYK+
Sbjct: 885 TGPSSA-----TVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVL 939
Query: 655 YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQ 704
Y+ Q I +T LS L Y + + +++ DG ++Q
Sbjct: 940 YRWNRQSSTSVI--ETNKTSVELS-LPFDEDYIIEIKPFSDGGDGSSSEQ 986
Score = 127 bits (319), Expect = 6e-29
Identities = 181/743 (24%), Positives = 294/743 (39%), Gaps = 92/743 (12%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGR 101
V+ P+ V + V L+C A G + W + K K SNG L I +
Sbjct: 229 VQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQ-- 286
Query: 102 RGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVAR-----FAC 156
Q D G Y+C+A N G ++A ++ + ++++ VA + C
Sbjct: 287 ---QEDAGLYECVAENSRGK------NVARGQLTFYAQPNWIQKINDIHVAMEENVFWEC 337
Query: 157 KISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKS 216
K + P W N L +T DRI + G L I V+ D+G Y+C+A H
Sbjct: 338 KANGRPKPTYKWLKNGEPL-LTRDRIQ-IEQGTLNITIVNLSDAGMYQCLAEN-KHGVIF 394
Query: 217 MEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT--------VVLECMATGNPKPIISW 268
A L+VI GP T L + VV+EC +PKP+ +W
Sbjct: 395 SNAELSVIAV-------------GPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTW 441
Query: 269 SRLDHKSIDVFNTRVL--GNGNLMISDVRLQHAGVYVCRATTP-GTRNFT---VAMATLT 322
+ + I N R+ +GNL I +V AG Y C AT GT + T V
Sbjct: 442 KK--GRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR 499
Query: 323 VLAPPSFVEWP--ESLTRPRAGTARFVCQAEGIPSPKM--SWLKNGRKIHSNG------R 372
V+ PPS ++ ES+ P CQ S + +W NG I + R
Sbjct: 500 VMVPPSSMDVTVGESIVLP--------CQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFER 551
Query: 373 IKMYNSK--LVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETM 430
+ +S L+I I + Y CM + S + + A L V P P V + +
Sbjct: 552 VGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV---RGPPGPPEAVTIDEI 608
Query: 431 SSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVV---IGNDTTHYIIDDLEPAS 487
+ + L+W N + Y + + + V I T + L P
Sbjct: 609 TDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWV 668
Query: 488 NYTFYIVAYMPMGASQMSDHVTQNTLEDV--PLRPPEISLTSRSPTDILISWLPIPAKYR 545
Y F VA +G + S + E+ + P +S S ++++I+W +P + +
Sbjct: 669 EYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQ 728
Query: 546 RGQVVLYRLSFRLSTENSIQVLEL---PGTTHEYLLEGLKPDSVYLVRITAATRVGLGES 602
G+ Y ++FR + + L + + + E + P S + V++ G G
Sbjct: 729 NGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPF 788
Query: 603 SVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVE-DTAAIQGYKL-YYKEEGQ 660
S T + + K P S + L+ T I V W +E + IQGY++ Y++ E +
Sbjct: 789 SPTTVVYSAEEEPTKPPAS--IFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDK 846
Query: 661 QENGPIFLDTKDLLYT-LSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMV 719
+EN + T ++ L YH+ + AYN+ G + V+V R
Sbjct: 847 EENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTG-------PSSATVNVTTRKP 899
Query: 720 PPPPPPHHLYAKANTSSSIFLHW 742
PP PP ++ ++ S I L+W
Sbjct: 900 PPSQPPGNIIWN-SSDSKIILNW 921
Score = 89.4 bits (220), Expect = 2e-17
Identities = 132/605 (21%), Positives = 233/605 (38%), Gaps = 74/605 (12%)
Query: 56 VVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLA 115
VV++C+ TW K + EN+RI + +G+L I V +SD G Y C+A
Sbjct: 425 VVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVT-----KSDAGSYTCIA 479
Query: 116 MNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPA--VITWEFNRT 173
N +G S +L + + V P S +V G C+++ V TW FN
Sbjct: 480 TNHFGTA-SSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGH 538
Query: 174 TLPMTMD-----RITALPT-GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAK 227
+ D R+ + G L I ++ + +G Y C+ T R + + P
Sbjct: 539 LIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPG 598
Query: 228 ESKSFHTPTII---------AGPQNITTSLHQTVVLECMATGNPKPIISWSRLDH--KSI 276
++ I GP N H + + + P + W + + I
Sbjct: 599 PPEAVTIDEITDTTAQLSWRPGPDN-----HSPITMYVIQARTPFSV-GWQAVSTVPELI 652
Query: 277 D--VFNTRVLGNGNLMISDVRLQHAGVY-VCRATTPGTRNFTV-AMATLTVLAPPSFVEW 332
D F V+G + + R A V + + P + T A+ +T
Sbjct: 653 DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVT---------- 702
Query: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAI 392
P +++ + V E +P L+NGR + Y + + ++ DA
Sbjct: 703 PANVSGGGGSKSELVITWETVPEE----LQNGRGFGYVVAFRPYGKMIWMLTVLASADAS 758
Query: 393 YQCMAE----------------NSQGSILSRARLTVVMSEDRPSAP-YNVHAETMSSSAI 435
N++G V +E+ P+ P ++ A ++S++ I
Sbjct: 759 RYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDI 818
Query: 436 LLAWERPLY-NSDKVIAYSVHYMKAEGLNNEEYQV-VIGNDTTHYIIDDLEPASNYTFYI 493
+ W PL N ++ Y V Y + E ++ +GN T+ I + L+ + Y +
Sbjct: 819 EVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITN-LKGSVLYHLAV 877
Query: 494 VAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQVVLYR 553
AY G S V T + P +PP + + S + I+++W + A +V Y+
Sbjct: 878 KAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYK 937
Query: 554 LSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKA 613
+ +R + ++S V+E T+ E L D Y++ I + G G SS R PK
Sbjct: 938 VLYRWNRQSSTSVIETNKTSVEL---SLPFDEDYIIEIKPFSDGGDGSSS--EQIRIPKI 992
Query: 614 TSVKA 618
++ A
Sbjct: 993 SNAYA 997
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 170 bits (430), Expect = 8e-42
Identities = 120/388 (30%), Positives = 183/388 (47%), Gaps = 26/388 (6%)
Query: 44 EPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMS--ENKRIEVLSNGSLYISEVEGR 101
EPQD VT + V C+A G ++ WL+N ++S + R+ +L +G+L I +
Sbjct: 251 EPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQ-- 308
Query: 102 RGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA---FEVQPISTEVHEGGVARFACKI 158
++D+G YQC+A N G + +Q+ L A F +QP +TEV G C
Sbjct: 309 ---ETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
Query: 159 SSHPPAVITW-EFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSM 217
+ HPP I+W +RT LP+ R+ P+G L I +V Q DSG Y C A + S+
Sbjct: 366 TGHPPPRISWTRGDRTPLPVD-PRVNITPSGGLYIQNVVQGDSGEYACSA---TNNIDSV 421
Query: 218 EASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSID 277
A+ +I P PQ+ QTV +C A GNP P+I+W++ +
Sbjct: 422 HATAFIIVQA------LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 278 VFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLT 337
VL +G L IS V L G Y C+A VA T+ P F P T
Sbjct: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
Query: 338 RPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMY-NSKLVINQIIPEDDAIYQCM 396
+ C ++G P P ++W K+G ++ +G+ + L IN + P D Y+C+
Sbjct: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
Query: 397 AENSQGSILSRARLTVVMSEDRPSAPYN 424
A N+ GS A +++V+S + P N
Sbjct: 596 ARNTIGS----ASVSMVLSVNVPDVSRN 619
Score = 111 bits (278), Expect = 3e-24
Identities = 81/282 (28%), Positives = 129/282 (45%), Gaps = 16/282 (5%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLK-NGAKMSENKRIEVLSNGSLYISEV 98
+FV +PQ+ V + V L+C A G P +++W + + + + R+ + +G LYI V
Sbjct: 343 TFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNV 402
Query: 99 EGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKI 158
Q D G Y C A N ++ A + + + F V P V EG F C+
Sbjct: 403 -----VQGDSGEYACSATNNIDSV-HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEA 456
Query: 159 SSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSME 218
+PP VI W + L + R L +G L+I V+ D G Y C A + +K +
Sbjct: 457 KGNPPPVIAWTKGGSQLSVDR-RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQK-VV 514
Query: 219 ASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDV 278
A LTV P TP + P + T + V L C + G P+P I+W++ + +
Sbjct: 515 AHLTVQPRV------TPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES 568
Query: 279 FNTRVLGNGNLMISDVRLQHAGVYVCRA-TTPGTRNFTVAMA 319
+ G L I+DV AG Y C A T G+ + ++ ++
Sbjct: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLS 610
Score = 83.2 bits (204), Expect = 1e-15
Identities = 64/189 (33%), Positives = 86/189 (45%), Gaps = 16/189 (8%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEG 100
F PQD V V C+A G P + W K G+++S ++R VLS+G+L IS V
Sbjct: 435 FTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGV-- 492
Query: 101 RRGEQSDEGFYQCLAMNKYGAILSQK--AHLALS--TISAFEVQPISTEVHEGGVARFAC 156
D+G Y+C A+N G SQK AHL + F P T V G + C
Sbjct: 493 ---ALHDQGQYECQAVNIIG---SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPC 546
Query: 157 KISSHPPAVITWEFNRTTLPMT-MDRITALPTGVLQIYDVSQRDSGNYRCIAA-TVAHRR 214
P ITW N+ + +T + P G L I DV D+G Y C+A T+
Sbjct: 547 SSQGEPEPAITW--NKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
Query: 215 KSMEASLTV 223
SM S+ V
Sbjct: 605 VSMVLSVNV 613
Score = 75.5 bits (184), Expect = 3e-13
Identities = 61/220 (27%), Positives = 98/220 (44%), Gaps = 8/220 (3%)
Query: 199 DSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMA 258
+SGN + A RR + T+ P E + P I + PQ+ + TV C A
Sbjct: 212 ESGNAQAAAICEYPRRIQGRSVATITP--EELNCERPRITSEPQDADVTSGNTVYFTCRA 269
Query: 259 TGNPKPIISWSRLDHKSIDVFNTR--VLGNGNLMISDVRLQHAGVYVCRATTPG--TRNF 314
GNPKP I W R +++ ++R +L +G LMI + + G+Y C A +
Sbjct: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
Query: 315 TVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGR-KIHSNGRI 373
V + A P+FV P++ + C A G P P++SW + R + + R+
Sbjct: 330 EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRV 389
Query: 374 KMYNS-KLVINQIIPEDDAIYQCMAENSQGSILSRARLTV 412
+ S L I ++ D Y C A N+ S+ + A + V
Sbjct: 390 NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 169 bits (429), Expect = 1e-41
Identities = 173/668 (25%), Positives = 268/668 (40%), Gaps = 73/668 (10%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P D+ V++ +P L+C+A G + W K G ++ +K +L +GSL+
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S A L ++ + F P V G A
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 156 CKIS-SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I+W+ + + L +RIT + G L I + D+G Y C+ + R
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
+S A LTV+ P+ + P N+ ++ + +C A G+P P + W R D
Sbjct: 211 ESEVAELTVL--------ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDG 261
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPE 334
+ + + L I V G Y C A + A ATLTV PP FV P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQEPPHFVVKPR 319
Query: 335 SLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKM-YNSKLVINQI 385
T F C+A G P P + W + G + S+ R + L I +
Sbjct: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
Query: 386 IPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAE---TMSSSAIL 436
D Y C N GSI+++A L V + DRP P N T S +
Sbjct: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
Query: 437 LAWERP--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDLEPASNYTF- 491
P L+ D V+ S + + L N Q+ DT Y P+ T+
Sbjct: 440 TGSPVPTILWRKDGVLV-STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 498
Query: 492 YIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP------IPAKYR 545
+ G T L +P P + +T S + +SW P P Y
Sbjct: 499 AYIEVQEFGVPVQPPRPTDPNL--IPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY- 555
Query: 546 RGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS-- 603
+F ++ +S Q + T ++GLKP+++YL + AA G+ + S
Sbjct: 556 ------IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609
Query: 604 ---VWTSHRTPKATSVKAPK------SPELHLE---PLNCTTISVRWQQDVEDTAAIQGY 651
V T P + V + + LHL L+ ++I V W D + + IQGY
Sbjct: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGY 668
Query: 652 KLYYKEEG 659
K+ Y+ G
Sbjct: 669 KILYRPSG 676
Score = 144 bits (363), Expect = 5e-34
Identities = 176/714 (24%), Positives = 289/714 (40%), Gaps = 71/714 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQ-AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P V++CQ G ++W K+G+ + + + G L I+
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT- 191
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S+ A L + +F +P + V A F C+
Sbjct: 192 ----RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W + LP + R L+I V+ D G+Y C+A + + ++ A
Sbjct: 248 GDPVPTVRWRKDDGELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SA 304
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
+LTV P + P++ +L +TV +C ATGNP+P I W R +++ +F
Sbjct: 305 TLTV--------QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL-LF 355
Query: 280 NTR---------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-VLA---P 326
+ + V G+L I++V+ G Y+C+ T A +T V+A P
Sbjct: 356 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 415
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS-NGRIK-MYNSKLVINQ 384
P + P + T GT C A G P P + W K+G + + + RIK + N L I
Sbjct: 416 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475
Query: 385 IIPEDDAIYQCMAENSQGSILSRARLT-----VVMSEDR-------PSAPYNVHAETMSS 432
D Y C+A G A + V + R PSAP +S
Sbjct: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 535
Query: 433 SAILLAWERPLYNSDKVIAYSVH-YMKAEGLNNEEYQVVIGN-DTTHYIIDDLEPASNYT 490
+ + L+W+ L + +Y + + A G +Q V N T I L+P + Y
Sbjct: 536 NTVTLSWQPNLNSGATPTSYIIEAFSHASG---SSWQTVAENVKTETSAIKGLKPNAIYL 592
Query: 491 FYIVAYMPMG---ASQMSDHV-TQNTL---EDVPLRPPEISL----------TSRSPTDI 533
F + A G SQ+SD V TQ+ L + V + + L T S + I
Sbjct: 593 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 652
Query: 534 LISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRI 591
+ W + ++Y +G +LYR S E+ V E+ + ++ L+ Y ++
Sbjct: 653 EVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 712
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQ 649
G S +T + P+ + N T I V WQ EDT +Q
Sbjct: 713 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 772
Query: 650 GYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
YK++ + + +D + L P +Y V + A G +++
Sbjct: 773 EYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 826
Score = 135 bits (340), Expect = 2e-31
Identities = 211/899 (23%), Positives = 341/899 (37%), Gaps = 97/899 (10%)
Query: 141 PISTEVHEGGVARFACKISSHPPAVITW----EFNRTTLPMTMDRITALPTGVLQIYDV- 195
P V +G A CK P I W E T LP+G L +
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 196 ----SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251
S+ D G Y C+A S ASL V ++ P ++ ++ +
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVMVAVGEP 147
Query: 252 VVLECMAT-GNPKPIISWSRLDHKSIDVFNTRV-LGNGNLMISDVRLQHAGVYVCRATTP 309
V+EC G+P+P ISW + D +D + R+ + G LMI+ R AG YVC T
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 310 -GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH 368
G R VA LTVL PSFV+ P +L +A F C+A G P P + W K+ ++
Sbjct: 207 VGERESEVA--ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 369 SNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTV-------VMSEDRPSA 421
+ + L I ++ D Y C+AEN G + A LTV V D+ A
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 324
Query: 422 ---PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGN----D 474
E + + W R + + + +Y + ++ + I N D
Sbjct: 325 LGRTVTFQCEATGNPQPAIFWRRE-GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 383
Query: 475 TTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE--ISLTSRSPTD 532
+YI L A + AY+ +++D + + P +++
Sbjct: 384 VGYYICQTLNVAGS--IITKAYL-----EVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
Query: 533 ILISWLPIPA-KYRRGQVVLYRLSFRLST-ENSIQVLELP--GTTHEYLLEGLKPDSVYL 588
+ + P+P +R+ V++ R+ EN + + G T Y P
Sbjct: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG--- 493
Query: 589 VRITAATRVGLGESSVWTSHRTPKATSV--KAPKSPELHLEPLNCTTISVRWQQDVEDTA 646
T + + + E V P ++ AP PE+ ++ T+++ WQ ++ A
Sbjct: 494 -EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPNLNSGA 550
Query: 647 AIQGYKLY-YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN--NIDDGYQAD 703
Y + + + + K + GL P Y + A N I D Q
Sbjct: 551 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
Query: 704 QTVST----PGCVSVRDRMVPPPPPPHHLYAKANT---SSSIFLHWRRPAFTAAQIINYT 756
V T P V + V L+ T SSSI +HW + I Y
Sbjct: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGYK 669
Query: 757 IRCNPVGLQNAS---LVLYLQT-SETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH 812
I P G + LV ++T ++ +++ L YE R ++ S + +
Sbjct: 670 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA 729
Query: 813 STLPEAPAGPPVGVKVTLIEDD--TALVSWKPP--DGPETVVTRYTILYASRKAWIAGEW 868
TL EAP+ PP GV V+ + + LVSW+PP D +V Y K W G
Sbjct: 730 KTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY-------KVWCLGNE 782
Query: 869 QVLH----REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQ 924
H +G+ ++ LV G Y V+++AS G G S + + +++
Sbjct: 783 TRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL------DAHG 836
Query: 925 RPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKT 983
P S + +V D G+G A IL+ I +YR + +++ + T
Sbjct: 837 NPV---SPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST 892
Score = 103 bits (257), Expect = 9e-22
Identities = 88/279 (31%), Positives = 126/279 (45%), Gaps = 20/279 (7%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
SFVK P ++ VT D C+A G+ V W K+ ++ ++ R E+ + +L I +V
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVT 282
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
D G Y C+A N G A L + F V+P V G F C+ +
Sbjct: 283 A-----GDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 336
Query: 160 SHPPAVITW--EFNRTTL-----PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAH 212
+P I W E ++ L P + R + TG L I +V + D G Y C VA
Sbjct: 337 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 396
Query: 213 RRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLD 272
+ +A L V + P I GP N T ++ T VL C+ATG+P P I W R D
Sbjct: 397 SIIT-KAYLEVTDVIADRP--PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKD 452
Query: 273 HKSIDVFNTRV--LGNGNLMISDVRLQHAGVYVCRATTP 309
+ ++R+ L NG L I +L G Y C A+TP
Sbjct: 453 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 491
Score = 54.3 bits (129), Expect = 7e-07
Identities = 59/215 (27%), Positives = 86/215 (40%), Gaps = 18/215 (8%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 290 MISDVRLQHA-------GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
+R+ H GVYVC A + + + F + P +
Sbjct: 89 FF--LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 343 TARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 400
A CQ G P P +SW K+G + + RI + KL+I D Y C+ N
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 401 QGSILSR-ARLTVVMSEDRPSAPYNVHAETMSSSA 434
G S A LTV+ P N+ A T+ SA
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNL-AVTVDDSA 240
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P L + A C+AEG P+P + W K G ++ + + R+ + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILS-RARLTVVMSED 417
L +I+ D+ +Y C+A N G +S A L V + D
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD 131
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
5 precursor [Homo sapiens]
Length = 1502
Score = 169 bits (429), Expect = 1e-41
Identities = 185/713 (25%), Positives = 294/713 (41%), Gaps = 52/713 (7%)
Query: 20 ALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM 79
A LLLLLL+ + F + P D T CQA G+ K+ W K G K+
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 80 SENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALST---- 133
S N+R EV+ +GS + ++ R + DE Y+C+A N G I L
Sbjct: 65 S-NQRFEVIEFDDGSGSVLRIQPLRTPR-DEAIYECVASNNVGEISVSTRLTVLREDQIP 122
Query: 134 --ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPT-- 187
++ P V A C S +P ITW +F RI L +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGG 182
Query: 188 ----GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQN 243
G LQI + D G Y C+A A R S A+L V +E + P P N
Sbjct: 183 TPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRV-PPRFSIPPTN 241
Query: 244 ITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYV 303
+V + C+A G+P P + W L + + + +G L ++DVR + Y
Sbjct: 242 HEIMPGGSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELNDVR--QSANYT 298
Query: 304 CRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKN 363
C A + T A+A +TV A P P + T+ + G P P ++
Sbjct: 299 CVAMS--TLGVIEAIAQITVKALPKPPGTP--VVTESTATSITLTWDSGNPEPVSYYIIQ 354
Query: 364 GRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRP 419
+ +S K + ++ + + P D ++ +A N+ G + SE P
Sbjct: 355 HKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 414
Query: 420 -SAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYM--KAEGLNNEEYQVVIGNDTT 476
SAP +V A +SS+ IL+ W+ P + ++ Y V+Y + +NN V + T
Sbjct: 415 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 474
Query: 477 HYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILIS 536
I +L P Y+ ++A+ +G +S + T VP +P S T IL+S
Sbjct: 475 --TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 532
Query: 537 WLPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRITAAT 595
W P R + Y L ++ Q + + PGT+ Y L+GLKP+S+Y R+ A +
Sbjct: 533 WTP----PRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLAARS 586
Query: 596 RVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYY 655
GLG S+ S RT ++ K H++ + T++ + W+ E+ + +K+ Y
Sbjct: 587 PQGLGASTAEISARTMQSMFAK-----NFHVKAVMKTSVLLSWEIP-ENYNSAMPFKILY 640
Query: 656 KEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVST 708
+ E +D + + L P + Y L N G Q T T
Sbjct: 641 DDGKMVEE----VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 689
Score = 140 bits (354), Expect = 5e-33
Identities = 177/693 (25%), Positives = 270/693 (38%), Gaps = 81/693 (11%)
Query: 137 FEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG---VLQIY 193
F P+ GGVA F C+ + P I W + + G VL+I
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 194 DV-SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKE-SKSFHTPTIIAGPQNITTSLHQT 251
+ + RD Y C+A+ S+ LTV+ + + F PTI GPQ +T
Sbjct: 86 PLRTPRDEAIYECVASNNVGEI-SVSTRLTVLREDQIPRGF--PTIDMGPQLKVVERTRT 142
Query: 252 VVLECMATGNPKPIISWSRLDHKSIDVFNT-------RVLGN---GNLMISDVRLQHAGV 301
+ C A+GNP P I+W + D +D N R G G L I G
Sbjct: 143 ATMLCAASGNPDPEITWFK-DFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQGK 201
Query: 302 YVCRAT-TPGTRNFTVAMATLTVL-----APPSFVEWPESLTRPRAGTARFVCQAEGIPS 355
Y C AT + GTR A + L PP F P + G+ C A G P
Sbjct: 202 YECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 261
Query: 356 PKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMS 415
P + W+ + + + + L +N + A Y C+A ++ G I + A++TV
Sbjct: 262 PYVKWMLGAEDLTPEDDMPIGRNVLELNDV--RQSANYTCVAMSTLGVIEAIAQITVKAL 319
Query: 416 EDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEE-YQVVIGND 474
P P + ++++I L W+ N + V Y + + N+EE Y+ + G
Sbjct: 320 PKPPGTPVVTES---TATSITLTWDSG--NPEPVSYYIIQHKPK---NSEELYKEIDGVA 371
Query: 475 TTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSPTDI 533
TT Y + L P S+Y F +VA +G S+ V T E P P ++ S T I
Sbjct: 372 TTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTI 431
Query: 534 LISWLPIPAKYRRGQVVLYRLSFRLSTENSI------QVLELPGTTHEYLLEGLKPDSVY 587
L+ W + GQ+ YR+ + + + V + TT + L P Y
Sbjct: 432 LVQWK--EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT----IGNLVPQKTY 485
Query: 588 LVRITAATRVGLGESSVWTSHRTPKATSVKAPKSP-ELHLEPLNCTTISVRWQQDVEDTA 646
V++ A T +G G S T P P EP + T+I + W DT
Sbjct: 486 SVKVLAFTSIGDGP----LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDT- 540
Query: 647 AIQGYKLYYK--EEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQ-AD 703
I Y+L YK E G+++ I T Y L GL P Y+ RL A + G A+
Sbjct: 541 -IANYELVYKDGEHGEEQRITIEPGTS---YRLQGLKPNSLYYFRLAARSPQGLGASTAE 596
Query: 704 QTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCN-PV 762
+ T + + + + KA +S+ L W P NY +
Sbjct: 597 ISARTMQSMFAK-----------NFHVKAVMKTSVLLSWEIPE-------NYNSAMPFKI 638
Query: 763 GLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
+ +V + T L+ L+P Y F +
Sbjct: 639 LYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVL 671
Score = 95.1 bits (235), Expect = 3e-19
Identities = 137/599 (22%), Positives = 237/599 (39%), Gaps = 50/599 (8%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYN------SK 379
PP F P T G A F+CQA G P PK+ W K G+K+ SN R ++ S
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV-SNQRFEVIEFDDGSGSV 81
Query: 380 LVINQI-IPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSA-------PYNVHAETMS 431
L I + P D+AIY+C+A N+ G I RLTV+ + P P E
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 432 SSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYI----IDDLEPAS 487
++ +L A N D I + ++ + NN + + T I+ E +
Sbjct: 142 TATMLCAASG---NPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESD 198
Query: 488 NYTFYIVAYMPMGASQMSD-HVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRR 546
+ VA G + ++ L +V PP S+ + +I+
Sbjct: 199 QGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNH-EIMPGGSVNITCVAV 257
Query: 547 GQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWT 606
G + Y + + L E+ ++P + L ++ + Y A + +G+ E+
Sbjct: 258 GSPMPY-VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTC--VAMSTLGVIEA---I 311
Query: 607 SHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGPI 666
+ T KA K P +P + T+I++ W D + + Y + +K + +E
Sbjct: 312 AQITVKALP-KPPGTPVV--TESTATSITLTW--DSGNPEPVSYYIIQHKPKNSEELYKE 366
Query: 667 FLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPH 726
Y+++GL P Y R++A NNI G ++ ++ + P P
Sbjct: 367 IDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT-------QTSEQAPSSAPR 419
Query: 727 HLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQG-L 785
+ A+ +S++I + W+ P QI Y + Q+ + + +++ + G L
Sbjct: 420 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNL 479
Query: 786 EPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDG 845
P Y V P S + T P G P+ K + + L+SW PP
Sbjct: 480 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPP-- 536
Query: 846 PETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEG 904
+ Y ++Y K GE Q + E T L+ L ++Y +++A + G G
Sbjct: 537 RSDTIANYELVY---KDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQGLG 591
Score = 70.5 bits (171), Expect = 9e-12
Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 10/194 (5%)
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQ---TSET 778
P PP +T++SI L W + + Y I+ P + LY + + T
Sbjct: 320 PKPPGTPVVTESTATSITLTW--DSGNPEPVSYYIIQHKPKNSEE----LYKEIDGVATT 373
Query: 779 HMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALV 838
V GL P + YEF V + P S V T +AP+ P V+ ++ T LV
Sbjct: 374 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 433
Query: 839 SWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISAS 898
WK P+ P + Y + Y W + H + + NLV Y VK+ A
Sbjct: 434 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNW-MKHNVADSQITTIGNLVPQKTYSVKVLAF 492
Query: 899 NEVGEGPFSNSVEL 912
+G+GP S+ +++
Sbjct: 493 TSIGDGPLSSDIQV 506
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 169 bits (429), Expect = 1e-41
Identities = 173/668 (25%), Positives = 268/668 (40%), Gaps = 73/668 (10%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P D+ V++ +P L+C+A G + W K G ++ +K +L +GSL+
Sbjct: 71 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 130
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S A L ++ + F P V G A
Sbjct: 131 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 190
Query: 156 CKIS-SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I+W+ + + L +RIT + G L I + D+G Y C+ + R
Sbjct: 191 CQPPRGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGER 249
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
+S A LTV+ P+ + P N+ ++ + +C A G+P P + W R D
Sbjct: 250 ESEVAELTVL--------ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDG 300
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPE 334
+ + + L I V G Y C A + A ATLTV PP FV P
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQEPPHFVVKPR 358
Query: 335 SLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKM-YNSKLVINQI 385
T F C+A G P P + W + G + S+ R + L I +
Sbjct: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 418
Query: 386 IPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAE---TMSSSAIL 436
D Y C N GSI+++A L V + DRP P N T S +
Sbjct: 419 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 478
Query: 437 LAWERP--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDLEPASNYTF- 491
P L+ D V+ S + + L N Q+ DT Y P+ T+
Sbjct: 479 TGSPVPTILWRKDGVLV-STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
Query: 492 YIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP------IPAKYR 545
+ G T L +P P + +T S + +SW P P Y
Sbjct: 538 AYIEVQEFGVPVQPPRPTDPNL--IPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY- 594
Query: 546 RGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS-- 603
+F ++ +S Q + T ++GLKP+++YL + AA G+ + S
Sbjct: 595 ------IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
Query: 604 ---VWTSHRTPKATSVKAPK------SPELHLE---PLNCTTISVRWQQDVEDTAAIQGY 651
V T P + V + + LHL L+ ++I V W D + + IQGY
Sbjct: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGY 707
Query: 652 KLYYKEEG 659
K+ Y+ G
Sbjct: 708 KILYRPSG 715
Score = 144 bits (363), Expect = 5e-34
Identities = 176/714 (24%), Positives = 289/714 (40%), Gaps = 71/714 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQ-AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P V++CQ G ++W K+G+ + + + G L I+
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT- 230
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S+ A L + +F +P + V A F C+
Sbjct: 231 ----RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W + LP + R L+I V+ D G+Y C+A + + ++ A
Sbjct: 287 GDPVPTVRWRKDDGELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SA 343
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
+LTV P + P++ +L +TV +C ATGNP+P I W R +++ +F
Sbjct: 344 TLTV--------QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL-LF 394
Query: 280 NTR---------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-VLA---P 326
+ + V G+L I++V+ G Y+C+ T A +T V+A P
Sbjct: 395 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS-NGRIK-MYNSKLVINQ 384
P + P + T GT C A G P P + W K+G + + + RIK + N L I
Sbjct: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514
Query: 385 IIPEDDAIYQCMAENSQGSILSRARLT-----VVMSEDR-------PSAPYNVHAETMSS 432
D Y C+A G A + V + R PSAP +S
Sbjct: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 574
Query: 433 SAILLAWERPLYNSDKVIAYSVH-YMKAEGLNNEEYQVVIGN-DTTHYIIDDLEPASNYT 490
+ + L+W+ L + +Y + + A G +Q V N T I L+P + Y
Sbjct: 575 NTVTLSWQPNLNSGATPTSYIIEAFSHASG---SSWQTVAENVKTETSAIKGLKPNAIYL 631
Query: 491 FYIVAYMPMG---ASQMSDHV-TQNTL---EDVPLRPPEISL----------TSRSPTDI 533
F + A G SQ+SD V TQ+ L + V + + L T S + I
Sbjct: 632 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 691
Query: 534 LISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRI 591
+ W + ++Y +G +LYR S E+ V E+ + ++ L+ Y ++
Sbjct: 692 EVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 751
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQ 649
G S +T + P+ + N T I V WQ EDT +Q
Sbjct: 752 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 811
Query: 650 GYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
YK++ + + +D + L P +Y V + A G +++
Sbjct: 812 EYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 865
Score = 135 bits (340), Expect = 2e-31
Identities = 211/899 (23%), Positives = 341/899 (37%), Gaps = 97/899 (10%)
Query: 141 PISTEVHEGGVARFACKISSHPPAVITW----EFNRTTLPMTMDRITALPTGVLQIYDV- 195
P V +G A CK P I W E T LP+G L +
Sbjct: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133
Query: 196 ----SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251
S+ D G Y C+A S ASL V ++ P ++ ++ +
Sbjct: 134 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVMVAVGEP 186
Query: 252 VVLECMAT-GNPKPIISWSRLDHKSIDVFNTRV-LGNGNLMISDVRLQHAGVYVCRATTP 309
V+EC G+P+P ISW + D +D + R+ + G LMI+ R AG YVC T
Sbjct: 187 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
Query: 310 -GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH 368
G R VA LTVL PSFV+ P +L +A F C+A G P P + W K+ ++
Sbjct: 246 VGERESEVA--ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 303
Query: 369 SNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTV-------VMSEDRPSA 421
+ + L I ++ D Y C+AEN G + A LTV V D+ A
Sbjct: 304 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 363
Query: 422 ---PYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGN----D 474
E + + W R + + + +Y + ++ + I N D
Sbjct: 364 LGRTVTFQCEATGNPQPAIFWRRE-GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 422
Query: 475 TTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPE--ISLTSRSPTD 532
+YI L A + AY+ +++D + + P +++
Sbjct: 423 VGYYICQTLNVAGS--IITKAYL-----EVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
Query: 533 ILISWLPIPA-KYRRGQVVLYRLSFRLST-ENSIQVLELP--GTTHEYLLEGLKPDSVYL 588
+ + P+P +R+ V++ R+ EN + + G T Y P
Sbjct: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG--- 532
Query: 589 VRITAATRVGLGESSVWTSHRTPKATSV--KAPKSPELHLEPLNCTTISVRWQQDVEDTA 646
T + + + E V P ++ AP PE+ ++ T+++ WQ ++ A
Sbjct: 533 -EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPNLNSGA 589
Query: 647 AIQGYKLY-YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN--NIDDGYQAD 703
Y + + + + K + GL P Y + A N I D Q
Sbjct: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
Query: 704 QTVST----PGCVSVRDRMVPPPPPPHHLYAKANT---SSSIFLHWRRPAFTAAQIINYT 756
V T P V + V L+ T SSSI +HW + I Y
Sbjct: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGYK 708
Query: 757 IRCNPVGLQNAS---LVLYLQT-SETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYH 812
I P G + LV ++T ++ +++ L YE R ++ S + +
Sbjct: 709 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFA 768
Query: 813 STLPEAPAGPPVGVKVTLIEDD--TALVSWKPP--DGPETVVTRYTILYASRKAWIAGEW 868
TL EAP+ PP GV V+ + + LVSW+PP D +V Y K W G
Sbjct: 769 KTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY-------KVWCLGNE 821
Query: 869 QVLH----REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESNQ 924
H +G+ ++ LV G Y V+++AS G G S + + +++
Sbjct: 822 TRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL------DAHG 875
Query: 925 RPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKT 983
P S + +V D G+G A IL+ I +YR + +++ + T
Sbjct: 876 NPV---SPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST 931
Score = 103 bits (257), Expect = 9e-22
Identities = 88/279 (31%), Positives = 126/279 (45%), Gaps = 20/279 (7%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
SFVK P ++ VT D C+A G+ V W K+ ++ ++ R E+ + +L I +V
Sbjct: 263 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVT 321
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
D G Y C+A N G A L + F V+P V G F C+ +
Sbjct: 322 A-----GDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 375
Query: 160 SHPPAVITW--EFNRTTL-----PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAH 212
+P I W E ++ L P + R + TG L I +V + D G Y C VA
Sbjct: 376 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 435
Query: 213 RRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLD 272
+ +A L V + P I GP N T ++ T VL C+ATG+P P I W R D
Sbjct: 436 SIIT-KAYLEVTDVIADRP--PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKD 491
Query: 273 HKSIDVFNTRV--LGNGNLMISDVRLQHAGVYVCRATTP 309
+ ++R+ L NG L I +L G Y C A+TP
Sbjct: 492 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 530
Score = 54.3 bits (129), Expect = 7e-07
Identities = 59/215 (27%), Positives = 86/215 (40%), Gaps = 18/215 (8%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 290 MISDVRLQHA-------GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
+R+ H GVYVC A + + + F + P +
Sbjct: 128 FF--LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 343 TARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 400
A CQ G P P +SW K+G + + RI + KL+I D Y C+ N
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
Query: 401 QGSILSR-ARLTVVMSEDRPSAPYNVHAETMSSSA 434
G S A LTV+ P N+ A T+ SA
Sbjct: 246 VGERESEVAELTVLERPSFVKRPSNL-AVTVDDSA 279
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P L + A C+AEG P+P + W K G ++ + + R+ + +
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILS-RARLTVVMSED 417
L +I+ D+ +Y C+A N G +S A L V + D
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD 170
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
4 precursor [Homo sapiens]
Length = 1501
Score = 168 bits (426), Expect = 2e-41
Identities = 185/716 (25%), Positives = 294/716 (41%), Gaps = 55/716 (7%)
Query: 20 ALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKM 79
A LLLLLL+ + F + P D T CQA G+ K+ W K G K+
Sbjct: 5 ARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV 64
Query: 80 SENKRIEVL--SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALST---- 133
S N+R EV+ +GS + ++ R + DE Y+C+A N G I L
Sbjct: 65 S-NQRFEVIEFDDGSGSVLRIQPLRTPR-DEAIYECVASNNVGEISVSTRLTVLREDQIP 122
Query: 134 --ISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--EFNRTTLPMTMDRITALPT-- 187
++ P V A C S +P ITW +F RI L +
Sbjct: 123 RGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSES 182
Query: 188 -------GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAG 240
G LQI + D G Y C+A A R S A+L V +E + P
Sbjct: 183 IGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRV-PPRFSIP 241
Query: 241 PQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAG 300
P N +V + C+A G+P P + W L + + + +G L ++DVR +
Sbjct: 242 PTNHEIMPGGSVNITCVAVGSPMPYVKW-MLGAEDLTPEDDMPIGRNVLELNDVR--QSA 298
Query: 301 VYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Y C A + T A+A +TV A P P + T+ + G P P +
Sbjct: 299 NYTCVAMS--TLGVIEAIAQITVKALPKPPGTP--VVTESTATSITLTWDSGNPEPVSYY 354
Query: 361 LKNGRKIHSNGRIK----MYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSE 416
+ + +S K + ++ + + P D ++ +A N+ G + SE
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 417 DRP-SAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYM--KAEGLNNEEYQVVIGN 473
P SAP +V A +SS+ IL+ W+ P + ++ Y V+Y + +NN V +
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADS 474
Query: 474 DTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDI 533
T I +L P Y+ ++A+ +G +S + T VP +P S T I
Sbjct: 475 QIT--TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSI 532
Query: 534 LISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRIT 592
L+SW P R + Y L ++ Q + + PGT+ Y L+GLKP+S+Y R+
Sbjct: 533 LLSWTP----PRSDTIANYELVYKDGEHGEEQRITIEPGTS--YRLQGLKPNSLYYFRLA 586
Query: 593 AATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYK 652
A + GLG S+ S RT ++ K H++ + T++ + W+ E+ + +K
Sbjct: 587 ARSPQGLGASTAEISARTMQSMFAK-----NFHVKAVMKTSVLLSWEIP-ENYNSAMPFK 640
Query: 653 LYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVST 708
+ Y + E +D + + L P + Y L N G Q T T
Sbjct: 641 ILYDDGKMVEE----VDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKT 692
Score = 140 bits (353), Expect = 7e-33
Identities = 176/696 (25%), Positives = 271/696 (38%), Gaps = 84/696 (12%)
Query: 137 FEVQPISTEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTG---VLQIY 193
F P+ GGVA F C+ + P I W + + G VL+I
Sbjct: 26 FTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQ 85
Query: 194 DV-SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKE-SKSFHTPTIIAGPQNITTSLHQT 251
+ + RD Y C+A+ S+ LTV+ + + F PTI GPQ +T
Sbjct: 86 PLRTPRDEAIYECVASNNVGEI-SVSTRLTVLREDQIPRGF--PTIDMGPQLKVVERTRT 142
Query: 252 VVLECMATGNPKPIISWSRLDHKSIDVFN---------TRVLGN----GNLMISDVRLQH 298
+ C A+GNP P I+W + D +D N + +G G L I
Sbjct: 143 ATMLCAASGNPDPEITWFK-DFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESD 201
Query: 299 AGVYVCRAT-TPGTRNFTVAMATLTVL-----APPSFVEWPESLTRPRAGTARFVCQAEG 352
G Y C AT + GTR A + L PP F P + G+ C A G
Sbjct: 202 QGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVG 261
Query: 353 IPSPKMSWLKNGRKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTV 412
P P + W+ + + + + L +N + A Y C+A ++ G I + A++TV
Sbjct: 262 SPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDV--RQSANYTCVAMSTLGVIEAIAQITV 319
Query: 413 VMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEE-YQVVI 471
P P + ++++I L W+ N + V Y + + N+EE Y+ +
Sbjct: 320 KALPKPPGTPVVTES---TATSITLTWDSG--NPEPVSYYIIQHKPK---NSEELYKEID 371
Query: 472 GNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPP-EISLTSRSP 530
G TT Y + L P S+Y F +VA +G S+ V T E P P ++ S
Sbjct: 372 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 431
Query: 531 TDILISWLPIPAKYRRGQVVLYRLSFRLSTENSI------QVLELPGTTHEYLLEGLKPD 584
T IL+ W + GQ+ YR+ + + + V + TT + L P
Sbjct: 432 TTILVQWK--EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITT----IGNLVPQ 485
Query: 585 SVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSP-ELHLEPLNCTTISVRWQQDVE 643
Y V++ A T +G G S T P P EP + T+I + W
Sbjct: 486 KTYSVKVLAFTSIGDGP----LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRS 541
Query: 644 DTAAIQGYKLYYK--EEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQ 701
DT I Y+L YK E G+++ I T Y L GL P Y+ RL A + G
Sbjct: 542 DT--IANYELVYKDGEHGEEQRITIEPGTS---YRLQGLKPNSLYYFRLAARSPQGLGAS 596
Query: 702 -ADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCN 760
A+ + T + + + + KA +S+ L W P NY
Sbjct: 597 TAEISARTMQSMFAK-----------NFHVKAVMKTSVLLSWEIPE-------NYNSAMP 638
Query: 761 -PVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
+ + +V + T L+ L+P Y F +
Sbjct: 639 FKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVL 674
Score = 94.4 bits (233), Expect = 6e-19
Identities = 137/602 (22%), Positives = 238/602 (39%), Gaps = 53/602 (8%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHSNGRIKMYN------SK 379
PP F P T G A F+CQA G P PK+ W K G+K+ SN R ++ S
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKV-SNQRFEVIEFDDGSGSV 81
Query: 380 LVINQI-IPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSA-------PYNVHAETMS 431
L I + P D+AIY+C+A N+ G I RLTV+ + P P E
Sbjct: 82 LRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTR 141
Query: 432 SSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNE------EYQVVIGNDTTHYI-IDDLE 484
++ +L A N D I + ++ + NN + + G + I+ E
Sbjct: 142 TATMLCAASG---NPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSE 198
Query: 485 PASNYTFYIVAYMPMGASQMSD-HVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAK 543
+ + VA G + ++ L +V PP S+ + +I+
Sbjct: 199 ESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNH-EIMPGGSVNITC 257
Query: 544 YRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESS 603
G + Y + + L E+ ++P + L ++ + Y A + +G+ E+
Sbjct: 258 VAVGSPMPY-VKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTC--VAMSTLGVIEA- 313
Query: 604 VWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQEN 663
+ T KA K P +P + T+I++ W D + + Y + +K + +E
Sbjct: 314 --IAQITVKALP-KPPGTPVV--TESTATSITLTW--DSGNPEPVSYYIIQHKPKNSEEL 366
Query: 664 GPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPP 723
Y+++GL P Y R++A NNI G ++ ++ + P
Sbjct: 367 YKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT-------QTSEQAPSS 419
Query: 724 PPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQ 783
P + A+ +S++I + W+ P QI Y + Q+ + + +++ +
Sbjct: 420 APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTI 479
Query: 784 G-LEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKP 842
G L P Y V P S + T P G P+ K + + L+SW P
Sbjct: 480 GNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTP 538
Query: 843 PDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVG 902
P + Y ++Y K GE Q + E T L+ L ++Y +++A + G
Sbjct: 539 P--RSDTIANYELVY---KDGEHGEEQRITIEPG-TSYRLQGLKPNSLYYFRLAARSPQG 592
Query: 903 EG 904
G
Sbjct: 593 LG 594
Score = 70.5 bits (171), Expect = 9e-12
Identities = 52/194 (26%), Positives = 81/194 (41%), Gaps = 10/194 (5%)
Query: 722 PPPPHHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQ---TSET 778
P PP +T++SI L W + + Y I+ P + LY + + T
Sbjct: 323 PKPPGTPVVTESTATSITLTW--DSGNPEPVSYYIIQHKPKNSEE----LYKEIDGVATT 376
Query: 779 HMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALV 838
V GL P + YEF V + P S V T +AP+ P V+ ++ T LV
Sbjct: 377 RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
Query: 839 SWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISAS 898
WK P+ P + Y + Y W + H + + NLV Y VK+ A
Sbjct: 437 QWKEPEEPNGQIQGYRVYYTMDPTQHVNNW-MKHNVADSQITTIGNLVPQKTYSVKVLAF 495
Query: 899 NEVGEGPFSNSVEL 912
+G+GP S+ +++
Sbjct: 496 TSIGDGPLSSDIQV 509
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 166 bits (420), Expect = 1e-40
Identities = 252/1048 (24%), Positives = 397/1048 (37%), Gaps = 127/1048 (12%)
Query: 55 PVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCL 114
P+VL+C A G + WL+ M ++ N +L + +V GE+ D+G Y+CL
Sbjct: 254 PLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKV----GEE-DDGEYRCL 308
Query: 115 AMNKYGAILSQKAHLALSTISAFEV---QPISTEVHEGGVARFACKISSHPPAVITWEFN 171
A N G+ H T+ A +P S G AR C++ P +TW N
Sbjct: 309 AENSLGSA----RHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRIN 364
Query: 172 RTTLP-MTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVI--PAKE 228
+ + D+ + G L + +V D+ +C A H A + V+ PAK
Sbjct: 365 GIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN-RHGLLLANAYIYVVQLPAK- 422
Query: 229 SKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVL---G 285
+ A Q T L C A G P P + W LD V
Sbjct: 423 -------ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQW--LDEDGTTVLQDERFFPYA 473
Query: 286 NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTAR 345
NG L I D++ G Y C A +N MA L V + P S +
Sbjct: 474 NGTLGIRDLQANDTGRYFCLAAND--QNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 531
Query: 346 FVCQAEGIPS--PKMSWLKNGRKIHSNGRIKMY---NSKLVINQIIPEDDAIYQCMAENS 400
F CQA PS P ++W +GR + G Y + +LVI+ + D Y C+A
Sbjct: 532 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTE 591
Query: 401 QGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAE 460
+ SRA+L VV S ++ S + ++W ++ + Y + + E
Sbjct: 592 LDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKE 651
Query: 461 GLNNEEYQV--VIGNDTTHYIIDDLEPASNYTFYIVA---YMPMGASQMSDHVTQNTLED 515
+ Y + V GN T+ + L P +YTF + A Y P S +S+ V T E
Sbjct: 652 MAPEKWYSLGKVPGNQTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVV--TPEA 707
Query: 516 VPLR-PPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTH 574
P + P ++ T+++I+W P+ V YR+ +R ++ +
Sbjct: 708 APEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQI--VSD 765
Query: 575 EYLLEGLKPDSV-YLVRITAATRVGLG-ESSV---WTSHRTPKATSVKAPKSPELH-LEP 628
+L+ V Y +++ A G G E V ++ P+A PEL +E
Sbjct: 766 PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI-------PELEGIEI 818
Query: 629 LNCTTISVRWQQ-DVEDTAA-IQGYKLYYKEEGQQ--------ENGPIFLDTKDLLYTLS 678
LN + + V+W+ D+ ++GY + Y EG Q + + LS
Sbjct: 819 LNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILS 878
Query: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSI 738
GL P YH+ + A+N G ++ T STP VP P HL ++NT S+
Sbjct: 879 GLRPYSSYHLEVQAFNGRGSGPASEFTFSTP-------EGVPGHPEALHLECQSNT--SL 929
Query: 739 FLHWRRPAFTAAQIINYTIRCNPV---GLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
L W+ P + Y + +P+ G S L TH L L P+ +Y F
Sbjct: 930 LLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTD-LSPHLRYRF-- 986
Query: 796 RLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTI 855
+L P +V G ++ ++VSW P +G R+ I
Sbjct: 987 QLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNF--RFHI 1044
Query: 856 LYASRKAWIAG----EWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVE 911
L+ + G V + + + T L+ +++ K E F + +
Sbjct: 1045 LFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFK--------ERMFRH--Q 1094
Query: 912 LAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLIL-- 969
+AV T P +G+ + G +G A+ +L+ +LIL
Sbjct: 1095 MAVKTNGTGRVRLPP-----------AGF------ATEGWFIGFVSAIILLLLVLLILCF 1137
Query: 970 IYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEE-----SLMPMIMP 1024
I RSK K S R G E N E A G+ + + P+
Sbjct: 1138 IKRSKGGKYSVKDKEDTQVDSEARPMKDETFG-EYSDNEEKAFGSSQPSLNGDIKPLGSD 1196
Query: 1025 NSFIDAKGGTDLIINSYGPIIKNNSKKK 1052
+S D G D+ N G I S KK
Sbjct: 1197 DSLADYGGSVDVQFNEDGSFIGQYSGKK 1224
Score = 110 bits (274), Expect = 1e-23
Identities = 203/948 (21%), Positives = 356/948 (37%), Gaps = 108/948 (11%)
Query: 18 LRALLLLLLLSPLPGVWCFSELS-----FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTW 72
LR + LLL SP + EL + P+ + V D + L C+A G+ ++ W
Sbjct: 5 LRYVWPLLLCSPCLLIQIPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRW 64
Query: 73 LKNGAKMSENKRIEVL-----SNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKA 127
++G + + V +GS I+ Q +G Y+C A NK G +S +
Sbjct: 65 TRDGVHFKPKEELGVTVYQSPHSGSFTITG-NNSNFAQRFQGIYRCFASNKLGTAMSHEI 123
Query: 128 HLALSTISAFEVQPIS-TEVHEGGVARFACKIS-SHPPAVITWEFNRTTLPMTMDRITAL 185
L + + + EV EG C S P I W ++ +R+T
Sbjct: 124 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMG 183
Query: 186 PTGVLQIYDVSQRDS-GNYRCIAATVAHRRKSMEASLTV-IPAKESKSFHTPTIIAGPQN 243
G L +V D+ +Y C A R + + + + A S P ++ P N
Sbjct: 184 QNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLF-PTN 242
Query: 244 ITTSL----HQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHA 299
++ L Q +VLEC+A G P P I W R T N L + V +
Sbjct: 243 SSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDD 302
Query: 300 GVYVCRATTP-GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKM 358
G Y C A G+ + TV A P ++ P+S TAR CQ +G P P++
Sbjct: 303 GEYRCLAENSLGSARHAYYV---TVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEV 359
Query: 359 SWLKNG---RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMS 415
+W NG ++ + + ++ L+++ + P D + QC A N G +L+ A + VV
Sbjct: 360 TWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL 419
Query: 416 EDR-PSAPYNVHAETMSSSAILL--AWERPLYNSDKVIAYSVHYMKAEG---LNNEEY-- 467
+ +A + S+A LL A+ P+ SV ++ +G L +E +
Sbjct: 420 PAKILTADNQTYMAVQGSTAYLLCKAFGAPV--------PSVQWLDEDGTTVLQDERFFP 471
Query: 468 --------QVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLR 519
+ + NDT Y +N T I+A + + + + +TQ + +
Sbjct: 472 YANGTLGIRDLQANDTGRYFCLAANDQNNVT--IMANLKV---KDATQITQGPRSTIEKK 526
Query: 520 PPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLE 579
++ T ++ D + P+ RG +Q L G + +Y +E
Sbjct: 527 GSRVTFTCQASFDPSLQ----PSITWRGD------------GRDLQEL---GDSDKYFIE 567
Query: 580 -------GLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCT 632
L A+T + + ES + + P+ L L +
Sbjct: 568 DGRLVIHSLDYSDQGNYSCVASTELDVVES---RAQLLVVGSPGPVPRLVLSDLHLLTQS 624
Query: 633 TISVRWQQDVEDTAAIQGYKLYY--KEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRL 690
+ V W + A I+ Y + + KE ++ + + T L P Y R+
Sbjct: 625 QVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRV 684
Query: 691 LAYNNIDDGYQA--DQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSIFLHWR--RPA 746
A N G + +TV TP P P + + N ++++ + W+ R
Sbjct: 685 TAINKYGPGEPSPVSETVVTPEAA--------PEKNPVDVKGEGNETTNMVITWKPLRWM 736
Query: 747 FTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPW 806
A + Y ++ P G + + S+ ++V YE V+ Q P
Sbjct: 737 DWNAPQVQYRVQWRPQGTRGPWQEQIV--SDPFLVVSNTSTFVPYEIKVQAVNSQGKGPE 794
Query: 807 SPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETV--VTRYTILYASRKAWI 864
V + + P P + ++ LV W+P D + + Y + Y +
Sbjct: 795 PQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQR 854
Query: 865 AGEWQVLHREGAI-----TMALLENLVAGNVYIVKISASNEVGEGPFS 907
+ +H++ + T +L L + Y +++ A N G GP S
Sbjct: 855 KHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS 902
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 166 bits (420), Expect = 1e-40
Identities = 252/1048 (24%), Positives = 397/1048 (37%), Gaps = 127/1048 (12%)
Query: 55 PVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCL 114
P+VL+C A G + WL+ M ++ N +L + +V GE+ D+G Y+CL
Sbjct: 259 PLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKV----GEE-DDGEYRCL 313
Query: 115 AMNKYGAILSQKAHLALSTISAFEV---QPISTEVHEGGVARFACKISSHPPAVITWEFN 171
A N G+ H T+ A +P S G AR C++ P +TW N
Sbjct: 314 AENSLGSA----RHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRIN 369
Query: 172 RTTLP-MTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVI--PAKE 228
+ + D+ + G L + +V D+ +C A H A + V+ PAK
Sbjct: 370 GIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARN-RHGLLLANAYIYVVQLPAK- 427
Query: 229 SKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVFNTRVL---G 285
+ A Q T L C A G P P + W LD V
Sbjct: 428 -------ILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQW--LDEDGTTVLQDERFFPYA 478
Query: 286 NGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTAR 345
NG L I D++ G Y C A +N MA L V + P S +
Sbjct: 479 NGTLGIRDLQANDTGRYFCLAAND--QNNVTIMANLKVKDATQITQGPRSTIEKKGSRVT 536
Query: 346 FVCQAEGIPS--PKMSWLKNGRKIHSNGRIKMY---NSKLVINQIIPEDDAIYQCMAENS 400
F CQA PS P ++W +GR + G Y + +LVI+ + D Y C+A
Sbjct: 537 FTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTE 596
Query: 401 QGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAE 460
+ SRA+L VV S ++ S + ++W ++ + Y + + E
Sbjct: 597 LDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKE 656
Query: 461 GLNNEEYQV--VIGNDTTHYIIDDLEPASNYTFYIVA---YMPMGASQMSDHVTQNTLED 515
+ Y + V GN T+ + L P +YTF + A Y P S +S+ V T E
Sbjct: 657 MAPEKWYSLGKVPGNQTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVV--TPEA 712
Query: 516 VPLR-PPEISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTH 574
P + P ++ T+++I+W P+ V YR+ +R ++ +
Sbjct: 713 APEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQI--VSD 770
Query: 575 EYLLEGLKPDSV-YLVRITAATRVGLG-ESSV---WTSHRTPKATSVKAPKSPELH-LEP 628
+L+ V Y +++ A G G E V ++ P+A PEL +E
Sbjct: 771 PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAI-------PELEGIEI 823
Query: 629 LNCTTISVRWQQ-DVEDTAA-IQGYKLYYKEEGQQ--------ENGPIFLDTKDLLYTLS 678
LN + + V+W+ D+ ++GY + Y EG Q + + LS
Sbjct: 824 LNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILS 883
Query: 679 GLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKANTSSSI 738
GL P YH+ + A+N G ++ T STP VP P HL ++NT S+
Sbjct: 884 GLRPYSSYHLEVQAFNGRGSGPASEFTFSTP-------EGVPGHPEALHLECQSNT--SL 934
Query: 739 FLHWRRPAFTAAQIINYTIRCNPV---GLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795
L W+ P + Y + +P+ G S L TH L L P+ +Y F
Sbjct: 935 LLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTD-LSPHLRYRF-- 991
Query: 796 RLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTI 855
+L P +V G ++ ++VSW P +G R+ I
Sbjct: 992 QLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNF--RFHI 1049
Query: 856 LYASRKAWIAG----EWQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVE 911
L+ + G V + + + T L+ +++ K E F + +
Sbjct: 1050 LFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFK--------ERMFRH--Q 1099
Query: 912 LAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLIL-- 969
+AV T P +G+ + G +G A+ +L+ +LIL
Sbjct: 1100 MAVKTNGTGRVRLPP-----------AGF------ATEGWFIGFVSAIILLLLVLLILCF 1142
Query: 970 IYRSKARKSSASKTAQNGTQQLPRTSASLASGNEVGKNLEGAVGNEE-----SLMPMIMP 1024
I RSK K S R G E N E A G+ + + P+
Sbjct: 1143 IKRSKGGKYSVKDKEDTQVDSEARPMKDETFG-EYSDNEEKAFGSSQPSLNGDIKPLGSD 1201
Query: 1025 NSFIDAKGGTDLIINSYGPIIKNNSKKK 1052
+S D G D+ N G I S KK
Sbjct: 1202 DSLADYGGSVDVQFNEDGSFIGQYSGKK 1229
Score = 109 bits (273), Expect = 1e-23
Identities = 194/918 (21%), Positives = 345/918 (37%), Gaps = 103/918 (11%)
Query: 43 KEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVL-----SNGSLYISE 97
+ P+ + V D + L C+A G+ ++ W ++G + + V +GS I+
Sbjct: 40 QSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITG 99
Query: 98 VEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPIS-TEVHEGGVARFAC 156
Q +G Y+C A NK G +S + L + + + EV EG C
Sbjct: 100 -NNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPC 158
Query: 157 KIS-SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDS-GNYRCIAATVAHRR 214
S P I W ++ +R+T G L +V D+ +Y C A R
Sbjct: 159 NPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRT 218
Query: 215 KSMEASLTV-IPAKESKSFHTPTIIAGPQNITTSL----HQTVVLECMATGNPKPIISWS 269
+ + + + A S P ++ P N ++ L Q +VLEC+A G P P I W
Sbjct: 219 IIQKEPIDLRVKATNSMIDRKPRLLF-PTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL 277
Query: 270 RLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTP-GTRNFTVAMATLTVLAPPS 328
R T N L + V + G Y C A G+ + TV A P
Sbjct: 278 RPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYV---TVEAAPY 334
Query: 329 FVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG---RKIHSNGRIKMYNSKLVINQI 385
++ P+S TAR CQ +G P P+++W NG ++ + + ++ L+++ +
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNV 394
Query: 386 IPEDDAIYQCMAENSQGSILSRARLTVVMSEDR-PSAPYNVHAETMSSSAILL--AWERP 442
P D + QC A N G +L+ A + VV + +A + S+A LL A+ P
Sbjct: 395 QPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAP 454
Query: 443 LYNSDKVIAYSVHYMKAEG---LNNEEY----------QVVIGNDTTHYIIDDLEPASNY 489
+ SV ++ +G L +E + + + NDT Y +N
Sbjct: 455 V--------PSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV 506
Query: 490 TFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLPIPAKYRRGQV 549
T I+A + + + + +TQ + + ++ T ++ D + P+ RG
Sbjct: 507 T--IMANLKV---KDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQ----PSITWRGD- 556
Query: 550 VLYRLSFRLSTENSIQVLELPGTTHEYLLE-------GLKPDSVYLVRITAATRVGLGES 602
+Q L G + +Y +E L A+T + + ES
Sbjct: 557 -----------GRDLQEL---GDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVES 602
Query: 603 SVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDTAAIQGYKLYY--KEEGQ 660
+ + P+ L L + + V W + A I+ Y + + KE
Sbjct: 603 ---RAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP 659
Query: 661 QENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQA--DQTVSTPGCVSVRDRM 718
++ + + T L P Y R+ A N G + +TV TP
Sbjct: 660 EKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA------ 713
Query: 719 VPPPPPPHHLYAKANTSSSIFLHWR--RPAFTAAQIINYTIRCNPVGLQNASLVLYLQTS 776
P P + + N ++++ + W+ R A + Y ++ P G + + S
Sbjct: 714 --PEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIV--S 769
Query: 777 ETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTA 836
+ ++V YE V+ Q P V + + P P + ++
Sbjct: 770 DPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAV 829
Query: 837 LVSWKPPDGPETV--VTRYTILYASRKAWIAGEWQVLHREGAI-----TMALLENLVAGN 889
LV W+P D + + Y + Y + + +H++ + T +L L +
Sbjct: 830 LVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYS 889
Query: 890 VYIVKISASNEVGEGPFS 907
Y +++ A N G GP S
Sbjct: 890 SYHLEVQAFNGRGSGPAS 907
Score = 108 bits (271), Expect = 2e-23
Identities = 153/690 (22%), Positives = 279/690 (40%), Gaps = 67/690 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEV--LSNGSLYISEV 98
++ +PQ + LDCQ G +VTW NG + E + + + G+L +S V
Sbjct: 335 WLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNV 394
Query: 99 EGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVH---EGGVARFA 155
+ SD QC A N++G +L+ A++ + + A ++ + + +G A
Sbjct: 395 Q-----PSDTMVTQCEARNRHGLLLAN-AYIYVVQLPA-KILTADNQTYMAVQGSTAYLL 447
Query: 156 CKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRK 215
CK P + W T + +R G L I D+ D+G Y C+AA
Sbjct: 448 CKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAAN-DQNNV 506
Query: 216 SMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP--KPIISW--SRL 271
++ A+L V A + I GP++ V C A+ +P +P I+W
Sbjct: 507 TIMANLKVKDATQ--------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGR 558
Query: 272 DHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPS--- 328
D + + + + +G L+I + G Y C A+T + + A L V+ P
Sbjct: 559 DLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVAST--ELDVVESRAQLLVVGSPGPVP 616
Query: 329 --FVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGR-----KIHSNGRIKMYNSKLV 381
+ LT+ + + + P K + K +S G++ +
Sbjct: 617 RLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTT 676
Query: 382 INQIIPEDDAIYQCMAENSQG-SILSRARLTVVMSEDRPSA-PYNVHAETMSSSAILLAW 439
+ ++ P ++ A N G S TVV E P P +V E ++ +++ W
Sbjct: 677 L-KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITW 735
Query: 440 ERPL----YNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVA 495
+PL +N+ +V Y V + + +G + ++ + ++ + Y + A
Sbjct: 736 -KPLRWMDWNAPQV-QYRVQW-RPQGTRGPWQEQIVSD--PFLVVSNTSTFVPYEIKVQA 790
Query: 496 YMPMGASQMSDHVTQNTLEDVPLRPPEI-SLTSRSPTDILISWLPIPAKYRRGQVVLYRL 554
G + ED P PE+ + + + +L+ W P+ +G + Y +
Sbjct: 791 VNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNV 850
Query: 555 SF------RLSTENSIQV--LELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWT 606
++ R ++ I + +P T +L GL+P S Y + + A G G +S +T
Sbjct: 851 TYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFT 910
Query: 607 SHRTPKATSVKAPKSPE-LHLEPLNCTTISVRWQQDVEDTAAIQGYKLYYKEEGQQENGP 665
TP+ P PE LHLE + T++ +RWQ + + GY L Y + G
Sbjct: 911 -FSTPEG----VPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQ 965
Query: 666 IFLDTKD---LLYTLSGLDPRRKYHVRLLA 692
+ + +D + L+ L P +Y +L A
Sbjct: 966 LSFNLRDPELRTHNLTDLSPHLRYRFQLQA 995
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 164 bits (416), Expect = 3e-40
Identities = 173/671 (25%), Positives = 268/671 (39%), Gaps = 76/671 (11%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P D+ V++ +P L+C+A G + W K G ++ +K +L +GSL+
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S A L ++ + F P V G A
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 156 CK-ISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I+W+ + + L +RIT + G L I + D+G Y C+ + R
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
+S A LTV+ P+ + P N+ ++ + +C A G+P P + W R D
Sbjct: 211 ESEVAELTVL--------ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDG 261
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLA---PPSFVE 331
+ + + L I V G Y C A + A ATLTV PP FV
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQVGSEPPHFVV 319
Query: 332 WPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKM-YNSKLVI 382
P T F C+A G P P + W + G + S+ R + L I
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 383 NQIIPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAE---TMSSS 433
+ D Y C N GSI+++A L V + DRP P N T S
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 434 AILLAWERP--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDLEPASNY 489
+ P L+ D V+ S + + L N Q+ DT Y P+
Sbjct: 440 CVATGSPVPTILWRKDGVLV-STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 490 TF-YIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP------IPA 542
T+ + G T L +P P + +T S + +SW P P
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNL--IPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 556
Query: 543 KYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGES 602
Y +F ++ +S Q + T ++GLKP+++YL + AA G+ +
Sbjct: 557 SY-------IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 603 S-----VWTSHRTPKATSVKAPK------SPELHLE---PLNCTTISVRWQQDVEDTAAI 648
S V T P + V + + LHL L+ ++I V W D + + I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYI 668
Query: 649 QGYKLYYKEEG 659
QGYK+ Y+ G
Sbjct: 669 QGYKILYRPSG 679
Score = 146 bits (369), Expect = 1e-34
Identities = 177/714 (24%), Positives = 290/714 (40%), Gaps = 68/714 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQ-AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P V++CQ G ++W K+G+ + + + G L I+
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT- 191
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S+ A L + +F +P + V A F C+
Sbjct: 192 ----RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W + LP + R L+I V+ D G+Y C+A + + ++ A
Sbjct: 248 GDPVPTVRWRKDDGELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SA 304
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
+LTV E P + P++ +L +TV +C ATGNP+P I W R +++ +F
Sbjct: 305 TLTVQVGSE-----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL-LF 358
Query: 280 NTR---------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-VLA---P 326
+ + V G+L I++V+ G Y+C+ T A +T V+A P
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 418
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS-NGRIK-MYNSKLVINQ 384
P + P + T GT C A G P P + W K+G + + + RIK + N L I
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 478
Query: 385 IIPEDDAIYQCMAENSQGSILSRARLT-----VVMSEDR-------PSAPYNVHAETMSS 432
D Y C+A G A + V + R PSAP +S
Sbjct: 479 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 538
Query: 433 SAILLAWERPLYNSDKVIAYSVH-YMKAEGLNNEEYQVVIGN-DTTHYIIDDLEPASNYT 490
+ + L+W+ L + +Y + + A G +Q V N T I L+P + Y
Sbjct: 539 NTVTLSWQPNLNSGATPTSYIIEAFSHASG---SSWQTVAENVKTETSAIKGLKPNAIYL 595
Query: 491 FYIVAYMPMG---ASQMSDHV-TQNTL---EDVPLRPPEISL----------TSRSPTDI 533
F + A G SQ+SD V TQ+ L + V + + L T S + I
Sbjct: 596 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 655
Query: 534 LISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRI 591
+ W + ++Y +G +LYR S E+ V E+ + ++ L+ Y ++
Sbjct: 656 EVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 715
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQ 649
G S +T + P+ + N T I V WQ EDT +Q
Sbjct: 716 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 775
Query: 650 GYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
YK++ + + +D + L P +Y V + A G +++
Sbjct: 776 EYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
Score = 138 bits (348), Expect = 3e-32
Identities = 209/900 (23%), Positives = 342/900 (38%), Gaps = 96/900 (10%)
Query: 141 PISTEVHEGGVARFACKISSHPPAVITW----EFNRTTLPMTMDRITALPTGVLQIYDV- 195
P V +G A CK P I W E T LP+G L +
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 196 ----SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251
S+ D G Y C+A S ASL V ++ P ++ ++ +
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVMVAVGEP 147
Query: 252 VVLECMAT-GNPKPIISWSRLDHKSIDVFNTRV-LGNGNLMISDVRLQHAGVYVCRATTP 309
V+EC G+P+P ISW + D +D + R+ + G LMI+ R AG YVC T
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 310 -GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH 368
G R VA LTVL PSFV+ P +L +A F C+A G P P + W K+ ++
Sbjct: 207 VGERESEVA--ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 369 SNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAE 428
+ + L I ++ D Y C+AEN G + A LTV + + P +
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 429 TMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID---DLE- 484
++ + N I + + EG N + ++ + + DL
Sbjct: 325 VVALGRTVTFQCEATGNPQPAI-----FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 485 ---PASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEI----------SLTSRSPT 531
S+ +YI + + S ++ + T + + RPP + ++
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVT-DVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 532 DILISWLPIPA-KYRRGQVVLYRLSFRLST-ENSIQVLELP--GTTHEYLLEGLKPDSVY 587
+ + P+P +R+ V++ R+ EN + + G T Y P
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG-- 496
Query: 588 LVRITAATRVGLGESSVWTSHRTPKATSV--KAPKSPELHLEPLNCTTISVRWQQDVEDT 645
T + + + E V P ++ AP PE+ ++ T+++ WQ ++
Sbjct: 497 --EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPNLNSG 552
Query: 646 AAIQGYKLY-YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN--NIDDGYQA 702
A Y + + + + K + GL P Y + A N I D Q
Sbjct: 553 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Query: 703 DQTVST----PGCVSVRDRMVPPPPPPHHLYAKANT---SSSIFLHWRRPAFTAAQIINY 755
V T P V + V L+ T SSSI +HW + I Y
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGY 671
Query: 756 TIRCNPVGLQNAS---LVLYLQT-SETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVY 811
I P G + LV ++T ++ +++ L YE R ++ S + +
Sbjct: 672 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 731
Query: 812 HSTLPEAPAGPPVGVKVTLIEDD--TALVSWKPP--DGPETVVTRYTILYASRKAWIAGE 867
TL EAP+ PP GV V+ + + LVSW+PP D +V Y K W G
Sbjct: 732 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY-------KVWCLGN 784
Query: 868 WQVLH----REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESN 923
H +G+ ++ LV G Y V+++AS G G S + + +++
Sbjct: 785 ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL------DAH 838
Query: 924 QRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKT 983
P S + +V D G+G A IL+ I +YR + +++ + T
Sbjct: 839 GNPV---SPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST 895
Score = 100 bits (249), Expect = 8e-21
Identities = 89/282 (31%), Positives = 127/282 (45%), Gaps = 23/282 (8%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
SFVK P ++ VT D C+A G+ V W K+ ++ ++ R E+ + +L I +V
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVT 282
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA---FEVQPISTEVHEGGVARFAC 156
D G Y C+A N G A L + S F V+P V G F C
Sbjct: 283 A-----GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 157 KISSHPPAVITW--EFNRTTL-----PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAAT 209
+ + +P I W E ++ L P + R + TG L I +V + D G Y C
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 210 VAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS 269
VA + +A L V + P I GP N T ++ T VL C+ATG+P P I W
Sbjct: 397 VAGSIIT-KAYLEVTDVIADRP--PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW- 452
Query: 270 RLDHKSIDVFNTRV--LGNGNLMISDVRLQHAGVYVCRATTP 309
R D + ++R+ L NG L I +L G Y C A+TP
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 54.3 bits (129), Expect = 7e-07
Identities = 59/215 (27%), Positives = 86/215 (40%), Gaps = 18/215 (8%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 290 MISDVRLQHA-------GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
+R+ H GVYVC A + + + F + P +
Sbjct: 89 FF--LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 343 TARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 400
A CQ G P P +SW K+G + + RI + KL+I D Y C+ N
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 401 QGSILSR-ARLTVVMSEDRPSAPYNVHAETMSSSA 434
G S A LTV+ P N+ A T+ SA
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNL-AVTVDDSA 240
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P L + A C+AEG P+P + W K G ++ + + R+ + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILS-RARLTVVMSED 417
L +I+ D+ +Y C+A N G +S A L V + D
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD 131
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 164 bits (416), Expect = 3e-40
Identities = 173/671 (25%), Positives = 268/671 (39%), Gaps = 76/671 (11%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P D+ V++ +P L+C+A G + W K G ++ +K +L +GSL+
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S A L ++ + F P V G A
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 156 CK-ISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I+W+ + + L +RIT + G L I + D+G Y C+ + R
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
+S A LTV+ P+ + P N+ ++ + +C A G+P P + W R D
Sbjct: 211 ESEVAELTVL--------ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDG 261
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLA---PPSFVE 331
+ + + L I V G Y C A + A ATLTV PP FV
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQVGSEPPHFVV 319
Query: 332 WPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKM-YNSKLVI 382
P T F C+A G P P + W + G + S+ R + L I
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 383 NQIIPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAE---TMSSS 433
+ D Y C N GSI+++A L V + DRP P N T S
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 434 AILLAWERP--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDLEPASNY 489
+ P L+ D V+ S + + L N Q+ DT Y P+
Sbjct: 440 CVATGSPVPTILWRKDGVLV-STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 490 TF-YIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP------IPA 542
T+ + G T L +P P + +T S + +SW P P
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNL--IPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 556
Query: 543 KYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGES 602
Y +F ++ +S Q + T ++GLKP+++YL + AA G+ +
Sbjct: 557 SY-------IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 603 S-----VWTSHRTPKATSVKAPK------SPELHLE---PLNCTTISVRWQQDVEDTAAI 648
S V T P + V + + LHL L+ ++I V W D + + I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYI 668
Query: 649 QGYKLYYKEEG 659
QGYK+ Y+ G
Sbjct: 669 QGYKILYRPSG 679
Score = 146 bits (369), Expect = 1e-34
Identities = 177/714 (24%), Positives = 290/714 (40%), Gaps = 68/714 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQ-AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P V++CQ G ++W K+G+ + + + G L I+
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT- 191
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S+ A L + +F +P + V A F C+
Sbjct: 192 ----RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W + LP + R L+I V+ D G+Y C+A + + ++ A
Sbjct: 248 GDPVPTVRWRKDDGELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SA 304
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
+LTV E P + P++ +L +TV +C ATGNP+P I W R +++ +F
Sbjct: 305 TLTVQVGSE-----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL-LF 358
Query: 280 NTR---------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-VLA---P 326
+ + V G+L I++V+ G Y+C+ T A +T V+A P
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 418
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS-NGRIK-MYNSKLVINQ 384
P + P + T GT C A G P P + W K+G + + + RIK + N L I
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 478
Query: 385 IIPEDDAIYQCMAENSQGSILSRARLT-----VVMSEDR-------PSAPYNVHAETMSS 432
D Y C+A G A + V + R PSAP +S
Sbjct: 479 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 538
Query: 433 SAILLAWERPLYNSDKVIAYSVH-YMKAEGLNNEEYQVVIGN-DTTHYIIDDLEPASNYT 490
+ + L+W+ L + +Y + + A G +Q V N T I L+P + Y
Sbjct: 539 NTVTLSWQPNLNSGATPTSYIIEAFSHASG---SSWQTVAENVKTETSAIKGLKPNAIYL 595
Query: 491 FYIVAYMPMG---ASQMSDHV-TQNTL---EDVPLRPPEISL----------TSRSPTDI 533
F + A G SQ+SD V TQ+ L + V + + L T S + I
Sbjct: 596 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 655
Query: 534 LISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRI 591
+ W + ++Y +G +LYR S E+ V E+ + ++ L+ Y ++
Sbjct: 656 EVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 715
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQ 649
G S +T + P+ + N T I V WQ EDT +Q
Sbjct: 716 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 775
Query: 650 GYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
YK++ + + +D + L P +Y V + A G +++
Sbjct: 776 EYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
Score = 138 bits (348), Expect = 3e-32
Identities = 209/900 (23%), Positives = 342/900 (38%), Gaps = 96/900 (10%)
Query: 141 PISTEVHEGGVARFACKISSHPPAVITW----EFNRTTLPMTMDRITALPTGVLQIYDV- 195
P V +G A CK P I W E T LP+G L +
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 196 ----SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251
S+ D G Y C+A S ASL V ++ P ++ ++ +
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVMVAVGEP 147
Query: 252 VVLECMAT-GNPKPIISWSRLDHKSIDVFNTRV-LGNGNLMISDVRLQHAGVYVCRATTP 309
V+EC G+P+P ISW + D +D + R+ + G LMI+ R AG YVC T
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 310 -GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH 368
G R VA LTVL PSFV+ P +L +A F C+A G P P + W K+ ++
Sbjct: 207 VGERESEVA--ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 369 SNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAE 428
+ + L I ++ D Y C+AEN G + A LTV + + P +
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 429 TMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID---DLE- 484
++ + N I + + EG N + ++ + + DL
Sbjct: 325 VVALGRTVTFQCEATGNPQPAI-----FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 485 ---PASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEI----------SLTSRSPT 531
S+ +YI + + S ++ + T + + RPP + ++
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVT-DVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 532 DILISWLPIPA-KYRRGQVVLYRLSFRLST-ENSIQVLELP--GTTHEYLLEGLKPDSVY 587
+ + P+P +R+ V++ R+ EN + + G T Y P
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG-- 496
Query: 588 LVRITAATRVGLGESSVWTSHRTPKATSV--KAPKSPELHLEPLNCTTISVRWQQDVEDT 645
T + + + E V P ++ AP PE+ ++ T+++ WQ ++
Sbjct: 497 --EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPNLNSG 552
Query: 646 AAIQGYKLY-YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN--NIDDGYQA 702
A Y + + + + K + GL P Y + A N I D Q
Sbjct: 553 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Query: 703 DQTVST----PGCVSVRDRMVPPPPPPHHLYAKANT---SSSIFLHWRRPAFTAAQIINY 755
V T P V + V L+ T SSSI +HW + I Y
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGY 671
Query: 756 TIRCNPVGLQNAS---LVLYLQT-SETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVY 811
I P G + LV ++T ++ +++ L YE R ++ S + +
Sbjct: 672 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 731
Query: 812 HSTLPEAPAGPPVGVKVTLIEDD--TALVSWKPP--DGPETVVTRYTILYASRKAWIAGE 867
TL EAP+ PP GV V+ + + LVSW+PP D +V Y K W G
Sbjct: 732 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY-------KVWCLGN 784
Query: 868 WQVLH----REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESN 923
H +G+ ++ LV G Y V+++AS G G S + + +++
Sbjct: 785 ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL------DAH 838
Query: 924 QRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKT 983
P S + +V D G+G A IL+ I +YR + +++ + T
Sbjct: 839 GNPV---SPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST 895
Score = 100 bits (249), Expect = 8e-21
Identities = 89/282 (31%), Positives = 127/282 (45%), Gaps = 23/282 (8%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
SFVK P ++ VT D C+A G+ V W K+ ++ ++ R E+ + +L I +V
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVT 282
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA---FEVQPISTEVHEGGVARFAC 156
D G Y C+A N G A L + S F V+P V G F C
Sbjct: 283 A-----GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 157 KISSHPPAVITW--EFNRTTL-----PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAAT 209
+ + +P I W E ++ L P + R + TG L I +V + D G Y C
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 210 VAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS 269
VA + +A L V + P I GP N T ++ T VL C+ATG+P P I W
Sbjct: 397 VAGSIIT-KAYLEVTDVIADRP--PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW- 452
Query: 270 RLDHKSIDVFNTRV--LGNGNLMISDVRLQHAGVYVCRATTP 309
R D + ++R+ L NG L I +L G Y C A+TP
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 54.3 bits (129), Expect = 7e-07
Identities = 59/215 (27%), Positives = 86/215 (40%), Gaps = 18/215 (8%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 290 MISDVRLQHA-------GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
+R+ H GVYVC A + + + F + P +
Sbjct: 89 FF--LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 343 TARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 400
A CQ G P P +SW K+G + + RI + KL+I D Y C+ N
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 401 QGSILSR-ARLTVVMSEDRPSAPYNVHAETMSSSA 434
G S A LTV+ P N+ A T+ SA
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNL-AVTVDDSA 240
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P L + A C+AEG P+P + W K G ++ + + R+ + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILS-RARLTVVMSED 417
L +I+ D+ +Y C+A N G +S A L V + D
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD 131
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 164 bits (416), Expect = 3e-40
Identities = 173/671 (25%), Positives = 268/671 (39%), Gaps = 76/671 (11%)
Query: 42 VKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENK-----RIEVLSNGSLYIS 96
V+ P D+ V++ +P L+C+A G + W K G ++ +K +L +GSL+
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTI-SAFEVQPISTEVHEGGVARFA 155
+ R + DEG Y C+A N G +S A L ++ + F P V G A
Sbjct: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
Query: 156 CK-ISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRR 214
C+ HP I+W+ + + L +RIT + G L I + D+G Y C+ + R
Sbjct: 152 CQPPRGHPEPTISWKKDGSPLDDKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
Query: 215 KSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHK 274
+S A LTV+ P+ + P N+ ++ + +C A G+P P + W R D
Sbjct: 211 ESEVAELTVL--------ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDG 261
Query: 275 SIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLTVLA---PPSFVE 331
+ + + L I V G Y C A + A ATLTV PP FV
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK--AEASATLTVQVGSEPPHFVV 319
Query: 332 WPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG--------RKIHSNGRIKM-YNSKLVI 382
P T F C+A G P P + W + G + S+ R + L I
Sbjct: 320 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 383 NQIIPEDDAIYQCMAENSQGSILSRARLTVV-MSEDRP-----SAPYNVHAE---TMSSS 433
+ D Y C N GSI+++A L V + DRP P N T S
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
Query: 434 AILLAWERP--LYNSDKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDLEPASNY 489
+ P L+ D V+ S + + L N Q+ DT Y P+
Sbjct: 440 CVATGSPVPTILWRKDGVLV-STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
Query: 490 TF-YIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP------IPA 542
T+ + G T L +P P + +T S + +SW P P
Sbjct: 499 TWSAYIEVQEFGVPVQPPRPTDPNL--IPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 556
Query: 543 KYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGES 602
Y +F ++ +S Q + T ++GLKP+++YL + AA G+ +
Sbjct: 557 SY-------IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
Query: 603 S-----VWTSHRTPKATSVKAPK------SPELHLE---PLNCTTISVRWQQDVEDTAAI 648
S V T P + V + + LHL L+ ++I V W D + + I
Sbjct: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYI 668
Query: 649 QGYKLYYKEEG 659
QGYK+ Y+ G
Sbjct: 669 QGYKILYRPSG 679
Score = 146 bits (369), Expect = 1e-34
Identities = 177/714 (24%), Positives = 290/714 (40%), Gaps = 68/714 (9%)
Query: 41 FVKEPQDVTVTRKDPVVLDCQ-AHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
F + P DV V +P V++CQ G ++W K+G+ + + + G L I+
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT- 191
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFACKIS 159
+SD G Y C+ N G S+ A L + +F +P + V A F C+
Sbjct: 192 ----RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 160 SHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEA 219
P + W + LP + R L+I V+ D G+Y C+A + + ++ A
Sbjct: 248 GDPVPTVRWRKDDGELPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SA 304
Query: 220 SLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWSRLDHKSIDVF 279
+LTV E P + P++ +L +TV +C ATGNP+P I W R +++ +F
Sbjct: 305 TLTVQVGSE-----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL-LF 358
Query: 280 NTR---------VLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMATLT-VLA---P 326
+ + V G+L I++V+ G Y+C+ T A +T V+A P
Sbjct: 359 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 418
Query: 327 PSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS-NGRIK-MYNSKLVINQ 384
P + P + T GT C A G P P + W K+G + + + RIK + N L I
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 478
Query: 385 IIPEDDAIYQCMAENSQGSILSRARLT-----VVMSEDR-------PSAPYNVHAETMSS 432
D Y C+A G A + V + R PSAP +S
Sbjct: 479 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSR 538
Query: 433 SAILLAWERPLYNSDKVIAYSVH-YMKAEGLNNEEYQVVIGN-DTTHYIIDDLEPASNYT 490
+ + L+W+ L + +Y + + A G +Q V N T I L+P + Y
Sbjct: 539 NTVTLSWQPNLNSGATPTSYIIEAFSHASG---SSWQTVAENVKTETSAIKGLKPNAIYL 595
Query: 491 FYIVAYMPMG---ASQMSDHV-TQNTL---EDVPLRPPEISL----------TSRSPTDI 533
F + A G SQ+SD V TQ+ L + V + + L T S + I
Sbjct: 596 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 655
Query: 534 LISW-LPIPAKYRRGQVVLYRLSFRLSTENSIQVLEL-PGTTHEYLLEGLKPDSVYLVRI 591
+ W + ++Y +G +LYR S E+ V E+ + ++ L+ Y ++
Sbjct: 656 EVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 715
Query: 592 TAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDVEDT--AAIQ 649
G S +T + P+ + N T I V WQ EDT +Q
Sbjct: 716 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 775
Query: 650 GYKLYYKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQAD 703
YK++ + + +D + L P +Y V + A G +++
Sbjct: 776 EYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
Score = 138 bits (348), Expect = 3e-32
Identities = 209/900 (23%), Positives = 342/900 (38%), Gaps = 96/900 (10%)
Query: 141 PISTEVHEGGVARFACKISSHPPAVITW----EFNRTTLPMTMDRITALPTGVLQIYDV- 195
P V +G A CK P I W E T LP+G L +
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 196 ----SQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251
S+ D G Y C+A S ASL V ++ P ++ ++ +
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVMVAVGEP 147
Query: 252 VVLECMAT-GNPKPIISWSRLDHKSIDVFNTRV-LGNGNLMISDVRLQHAGVYVCRATTP 309
V+EC G+P+P ISW + D +D + R+ + G LMI+ R AG YVC T
Sbjct: 148 AVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 310 -GTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH 368
G R VA LTVL PSFV+ P +L +A F C+A G P P + W K+ ++
Sbjct: 207 VGERESEVA--ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
Query: 369 SNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAE 428
+ + L I ++ D Y C+AEN G + A LTV + + P +
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 429 TMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIID---DLE- 484
++ + N I + + EG N + ++ + + DL
Sbjct: 325 VVALGRTVTFQCEATGNPQPAI-----FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
Query: 485 ---PASNYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEI----------SLTSRSPT 531
S+ +YI + + S ++ + T + + RPP + ++
Sbjct: 380 TNVQRSDVGYYICQTLNVAGSIITKAYLEVT-DVIADRPPPVIRQGPVNQTVAVDGTFVL 438
Query: 532 DILISWLPIPA-KYRRGQVVLYRLSFRLST-ENSIQVLELP--GTTHEYLLEGLKPDSVY 587
+ + P+P +R+ V++ R+ EN + + G T Y P
Sbjct: 439 SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG-- 496
Query: 588 LVRITAATRVGLGESSVWTSHRTPKATSV--KAPKSPELHLEPLNCTTISVRWQQDVEDT 645
T + + + E V P ++ AP PE+ ++ T+++ WQ ++
Sbjct: 497 --EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVTLSWQPNLNSG 552
Query: 646 AAIQGYKLY-YKEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAYN--NIDDGYQA 702
A Y + + + + K + GL P Y + A N I D Q
Sbjct: 553 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 612
Query: 703 DQTVST----PGCVSVRDRMVPPPPPPHHLYAKANT---SSSIFLHWRRPAFTAAQIINY 755
V T P V + V L+ T SSSI +HW + I Y
Sbjct: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGY 671
Query: 756 TIRCNPVGLQNAS---LVLYLQT-SETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVY 811
I P G + LV ++T ++ +++ L YE R ++ S + +
Sbjct: 672 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 731
Query: 812 HSTLPEAPAGPPVGVKVTLIEDD--TALVSWKPP--DGPETVVTRYTILYASRKAWIAGE 867
TL EAP+ PP GV V+ + + LVSW+PP D +V Y K W G
Sbjct: 732 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY-------KVWCLGN 784
Query: 868 WQVLH----REGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSVELAVLPKETSESN 923
H +G+ ++ LV G Y V+++AS G G S + + +++
Sbjct: 785 ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL------DAH 838
Query: 924 QRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSASKT 983
P S + +V D G+G A IL+ I +YR + +++ + T
Sbjct: 839 GNPV---SPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST 895
Score = 100 bits (249), Expect = 8e-21
Identities = 89/282 (31%), Positives = 127/282 (45%), Gaps = 23/282 (8%)
Query: 40 SFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGSLYISEVE 99
SFVK P ++ VT D C+A G+ V W K+ ++ ++ R E+ + +L I +V
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVT 282
Query: 100 GRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISA---FEVQPISTEVHEGGVARFAC 156
D G Y C+A N G A L + S F V+P V G F C
Sbjct: 283 A-----GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQC 336
Query: 157 KISSHPPAVITW--EFNRTTL-----PMTMDRITALPTGVLQIYDVSQRDSGNYRCIAAT 209
+ + +P I W E ++ L P + R + TG L I +V + D G Y C
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
Query: 210 VAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNPKPIISWS 269
VA + +A L V + P I GP N T ++ T VL C+ATG+P P I W
Sbjct: 397 VAGSIIT-KAYLEVTDVIADRP--PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW- 452
Query: 270 RLDHKSIDVFNTRV--LGNGNLMISDVRLQHAGVYVCRATTP 309
R D + ++R+ L NG L I +L G Y C A+TP
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 54.3 bits (129), Expect = 7e-07
Identities = 59/215 (27%), Positives = 86/215 (40%), Gaps = 18/215 (8%)
Query: 235 PTIIAGPQNITTSLHQTVVLECMATGNPKPIISW----SRLDHKSIDVFNTR-VLGNGNL 289
P I+ P ++ S + L C A G P P I W R++ D + R +L +G+L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 290 MISDVRLQHA-------GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAG 342
+R+ H GVYVC A + + + F + P +
Sbjct: 89 FF--LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 343 TARFVCQ-AEGIPSPKMSWLKNGRKI-HSNGRIKMYNSKLVINQIIPEDDAIYQCMAENS 400
A CQ G P P +SW K+G + + RI + KL+I D Y C+ N
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
Query: 401 QGSILSR-ARLTVVMSEDRPSAPYNVHAETMSSSA 434
G S A LTV+ P N+ A T+ SA
Sbjct: 207 VGERESEVAELTVLERPSFVKRPSNL-AVTVDDSA 240
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 326 PPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIHS------NGRIKMYNSK 379
PP VE P L + A C+AEG P+P + W K G ++ + + R+ + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 380 LVINQII-----PEDDAIYQCMAENSQGSILS-RARLTVVMSED 417
L +I+ D+ +Y C+A N G +S A L V + D
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD 131
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,401,874
Number of Sequences: 37866
Number of extensions: 2248965
Number of successful extensions: 17486
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 8753
Number of HSP's gapped (non-prelim): 3640
length of query: 1150
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1037
effective length of database: 13,968,660
effective search space: 14485500420
effective search space used: 14485500420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.