Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 140972063
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
(817 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo ... 1611 0.0
gi|93204861 protein phosphatase 1, regulatory (inhibitor) subuni... 652 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 76 1e-13
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 69 2e-11
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 69 2e-11
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 69 2e-11
gi|112382257 InaD-like [Homo sapiens] 69 2e-11
gi|87196343 PDZ domain containing 2 [Homo sapiens] 68 4e-11
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 65 2e-10
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 65 2e-10
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 65 2e-10
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 63 1e-09
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 62 2e-09
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 62 2e-09
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 62 3e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 6e-09
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 60 6e-09
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 60 6e-09
gi|44890059 involucrin [Homo sapiens] 59 1e-08
gi|45827729 scribble isoform b [Homo sapiens] 59 1e-08
gi|45827731 scribble isoform a [Homo sapiens] 59 1e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 59 2e-08
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 59 2e-08
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 59 2e-08
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 58 4e-08
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 58 4e-08
gi|148612825 Rap GTPase interactor [Homo sapiens] 58 4e-08
gi|148746195 trichohyalin [Homo sapiens] 57 5e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 57 9e-08
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 56 1e-07
>gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
Length = 817
Score = 1611 bits (4171), Expect = 0.0
Identities = 817/817 (100%), Positives = 817/817 (100%)
Query: 1 MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSM 60
MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSM
Sbjct: 1 MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSM 60
Query: 61 FLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSER 120
FLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSER
Sbjct: 61 FLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSER 120
Query: 121 VSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQD 180
VSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQD
Sbjct: 121 VSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQD 180
Query: 181 RKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVN 240
RKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVN
Sbjct: 181 RKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVN 240
Query: 241 SKLVSKRSRVFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKP 300
SKLVSKRSRVFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKP
Sbjct: 241 SKLVSKRSRVFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKP 300
Query: 301 VEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVA 360
VEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVA
Sbjct: 301 VEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVA 360
Query: 361 PPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEED 420
PPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEED
Sbjct: 361 PPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEED 420
Query: 421 GEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAAS 480
GEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAAS
Sbjct: 421 GEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAAS 480
Query: 481 AEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRD 540
AEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRD
Sbjct: 481 AEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRD 540
Query: 541 GRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLE 600
GRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLE
Sbjct: 541 GRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLE 600
Query: 601 QERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPV 660
QERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPV
Sbjct: 601 QERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPV 660
Query: 661 DMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERM 720
DMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERM
Sbjct: 661 DMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERM 720
Query: 721 EKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQR 780
EKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQR
Sbjct: 721 EKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQR 780
Query: 781 RVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST 817
RVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST
Sbjct: 781 RVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST 817
>gi|93204861 protein phosphatase 1, regulatory (inhibitor) subunit
9A [Homo sapiens]
Length = 1098
Score = 652 bits (1682), Expect = 0.0
Identities = 403/868 (46%), Positives = 521/868 (60%), Gaps = 93/868 (10%)
Query: 1 MMKTEPRGPGGPLRSASPHRSAYEAGIQALKP----PDAPGPDEAPKG-----AHHKKYG 51
M+KTE G LRSASPHR+AY QALK P + G + +G + +KYG
Sbjct: 1 MLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYG 60
Query: 52 SNVHRIKSMFLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHS--A 109
SNV+RIK++F+QMG + A + +G S R E ++ + +
Sbjct: 61 SNVNRIKNLFMQMGMEPNENA--------AVIAKTRGKGGHSSPQRRMKPKEFLEKTDGS 112
Query: 110 LLKLGTSVSERVSRFDSK-PAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGD-----K 163
++KL +SVSER+SRFD+ PS S+ ETRK+FERS + + K
Sbjct: 113 VVKLESSVSERISRFDTMYDGPSY---------SKFTETRKMFERSVHESGQNNRYSPKK 163
Query: 164 EAAARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDA--DAVSPTVSQLSAVFEKADSR 221
E A + E G + + GST++LD L + +AVSPTVSQLSAVFE DS
Sbjct: 164 EKAGGSEPQDEWGGSKSNR--------GSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSP 215
Query: 222 TGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAPS-GDAPAEKERCPAGQQPPQ 280
+ + ++ K + V P P+ + + + PP
Sbjct: 216 SAI--------------ISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPS 261
Query: 281 HRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAAS 340
++ + PV S + S PGE IQ + N T +
Sbjct: 262 NKRGV---DTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDK 318
Query: 341 PAPEEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKE----DFSEADLVDVS 396
PEEP A++ ++ +P + + + A V E + +KE DF+ D S
Sbjct: 319 DGPEEPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGGDFTSPDASASS 378
Query: 397 AYSGLGEDSA--------------------------GSALEEDDEDDEEDGEPPYEPESG 430
+ EDS G E DE+++ D Y+P+
Sbjct: 379 CGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSYYQPDME 438
Query: 431 CVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVE 490
EI GL EEE+ +RKI FS+API+VF+TYSNEDYDRRN++VDP+AASAEYELEKRVE
Sbjct: 439 YSEIVGLPEEEEIPANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVE 498
Query: 491 RLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
+LELFPVELEKD +GLGISIIGMG GAD GLEKLGIFVKTVTEGGAA RDGRIQVND +V
Sbjct: 499 KLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIV 558
Query: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMME 610
EVDG SLVGVTQ+FAA+VLRNTKG VRF+IGRE+PG+ SEVAQLI QTLEQER QRE++E
Sbjct: 559 EVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLE 618
Query: 611 QRYAQYGEDDEETGEYATDEDE-ELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVH 669
Q YAQY DD+ETGEYATDE+E E+ P PG +MAIEVFEL ENED SP +++ KL H
Sbjct: 619 QHYAQYDADDDETGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPSELDTSKLSH 678
Query: 670 KFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGE 729
KFKELQIKHAVTEAEIQ+LK KLQ+ E EK RW +EK QL+Q++EENKERM KLE YW E
Sbjct: 679 KFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLESYWIE 738
Query: 730 AQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELA 789
AQ+LC V+EHL+ETQ+QYQALE+KY+KAK+LIKD+QQKE++F+K++ A+R+ +E+ E A
Sbjct: 739 AQTLCHTVNEHLKETQSQYQALEKKYNKAKKLIKDFQQKELDFIKRQEAERKKIEDLEKA 798
Query: 790 RKEEMDKLLDKISELEGNLQTLRNSNST 817
E+ L +I +LE + L N T
Sbjct: 799 HLVEVQGLQVRIRDLEAEVFRLLKQNGT 826
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 76.3 bits (186), Expect = 1e-13
Identities = 44/102 (43%), Positives = 60/102 (58%), Gaps = 2/102 (1%)
Query: 490 ERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLL 549
E E F VEL K+ +GLGI+I G D LE GIFVK++T+ A DGRIQ+ D +
Sbjct: 371 EESETFDVELTKNVQGLGITIAGYIG--DKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
Query: 550 VEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
+ VDGT+L G T A VLR+T V + R +++E+
Sbjct: 429 IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAEL 470
Score = 67.0 bits (162), Expect = 7e-11
Identities = 38/84 (45%), Positives = 53/84 (63%), Gaps = 3/84 (3%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
+ LE+ +GLG SI+G G G+ G L I+VKTV GAA DGR++ D ++ V+G S
Sbjct: 1959 ITLERGPDGLGFSIVG-GYGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015
Query: 557 LVGVTQSFAASVLRNTKGRVRFMI 580
L GVT A ++L+ TKG V M+
Sbjct: 2016 LEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/165 (29%), Positives = 66/165 (40%), Gaps = 8/165 (4%)
Query: 476 PMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGG 535
P AAS V + +EL D GLG IIG A G+ VKT+ GG
Sbjct: 237 PSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKA--------TGVIVKTILPGG 288
Query: 536 AAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLI 595
A + GR+ D ++++ T L G++ A VLR RV+ MI R E++ L
Sbjct: 289 VADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALG 348
Query: 596 QQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPG 640
E+ Q GE+ E T + L T G
Sbjct: 349 ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG 393
Score = 58.9 bits (141), Expect = 2e-08
Identities = 40/107 (37%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
+E+ K GLG+SI+G G+D L I + V E GAA +DGR+ D ++EV+G
Sbjct: 1630 IEISKGRTGLGLSIVG---GSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGR-ERPGEQSEVAQLIQQTLEQE 602
L T A +VLR T RVR + R E P ++ EV + L+++
Sbjct: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKK 1731
Score = 57.8 bits (138), Expect = 4e-08
Identities = 43/163 (26%), Positives = 79/163 (48%), Gaps = 13/163 (7%)
Query: 424 PYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEY 483
P + ES + P L P PS + Q ++ ++D D+ +E +
Sbjct: 1282 PSQSESEPEKAP-LCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE-----FGYSWK 1335
Query: 484 ELEKRVERL--ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDG 541
+ +R L EL +ELEK GLG+S+ G + ++ +F+ + GAA +DG
Sbjct: 1336 NIRERYGTLTGELHMIELEKGHSGLGLSLAG-----NKDRSRMSVFIVGIDPNGAAGKDG 1390
Query: 542 RIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRER 584
R+Q+ D L+E++G L G + A+S+++ +V+ + R +
Sbjct: 1391 RLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNK 1433
Score = 57.0 bits (136), Expect = 7e-08
Identities = 50/187 (26%), Positives = 84/187 (44%), Gaps = 21/187 (11%)
Query: 470 RNEDVDPMAASAEYELE----KRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLG 525
+N++ +P +++ ++ K V+ LEL KD GLGI+I + G
Sbjct: 1458 QNKETEPTVTTSDAAVDLSSFKNVQHLEL-----PKDQGGLGIAISEEDTLS-------G 1505
Query: 526 IFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
+ +K++TE G A DGR++V D ++ VD +VG S+L+ K V+ I E P
Sbjct: 1506 VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENP 1565
Query: 586 GEQSEVAQLIQQTLEQERWQREMM-EQRYAQYGEDDEETGEYATD----EDEELSPTFPG 640
Q+ + + E++ + +M Q + E T +T D P PG
Sbjct: 1566 DSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPG 1625
Query: 641 GEMAIEV 647
E IE+
Sbjct: 1626 CETTIEI 1632
Score = 56.6 bits (135), Expect = 9e-08
Identities = 35/97 (36%), Positives = 56/97 (57%), Gaps = 8/97 (8%)
Query: 487 KRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVN 546
+ VE EL L+ S GLG S++G+ + +LGIFV+ + EG AHRDGR++
Sbjct: 133 RHVEVFEL----LKPPSGGLGFSVVGLRSE---NRGELGIFVQEIQEGSVAHRDGRLKET 185
Query: 547 DLLVEVDGTSL-VGVTQSFAASVLRNTKGRVRFMIGR 582
D ++ ++G +L +T A S+L+ K V+ +I R
Sbjct: 186 DQILAINGQALDQTITHQQAISILQKAKDTVQLVIAR 222
Score = 54.3 bits (129), Expect = 4e-07
Identities = 40/133 (30%), Positives = 62/133 (46%), Gaps = 12/133 (9%)
Query: 456 IQVFSTYSNEDYDRRNEDVDPMAASAE-----YELEKRVERLELFPVELEKDSEGLGISI 510
+ +FS+Y+ D E + +E Y + R+EL+ + S+ LGISI
Sbjct: 1111 LDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELW----REPSKSLGISI 1166
Query: 511 IG---MGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAAS 567
+G MG+ G GIF+K V E A ++G ++ D +VEVDG L + A
Sbjct: 1167 VGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVE 1226
Query: 568 VLRNTKGRVRFMI 580
+R V FM+
Sbjct: 1227 AIRKAGNPVVFMV 1239
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 8/89 (8%)
Query: 487 KRVERLELFPVELEKD-SEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQV 545
K E + +EL+K +GLG+SI+G G+FV + +GG A DGR+
Sbjct: 1716 KEEEVCDTLTIELQKKPGKGLGLSIVGKR-------NDTGVFVSDIVKGGIADADGRLMQ 1768
Query: 546 NDLLVEVDGTSLVGVTQSFAASVLRNTKG 574
D ++ V+G + TQ A++L+ ++G
Sbjct: 1769 GDQILMVNGEDVRNATQEAVAALLKVSEG 1797
Score = 46.6 bits (109), Expect = 9e-05
Identities = 28/85 (32%), Positives = 50/85 (58%), Gaps = 4/85 (4%)
Query: 497 VELEKD-SEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGT 555
VE++K ++ LGISI G G G+ +G + IF+ + G A + +++V D +V + GT
Sbjct: 1834 VEMKKGPTDSLGISIAG-GVGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGT 1890
Query: 556 SLVGVTQSFAASVLRNTKGRVRFMI 580
S G+T + A ++L+N G + +
Sbjct: 1891 STEGMTHTQAVNLLKNASGSIEMQV 1915
Score = 45.1 bits (105), Expect = 3e-04
Identities = 23/64 (35%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 507 GISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAA 566
G S +GM A+ + LG+ V+++ GGA RDGRI + D ++ ++ S + VT + A
Sbjct: 1014 GNSSLGMTVSANK--DGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQAR 1071
Query: 567 SVLR 570
++LR
Sbjct: 1072 AMLR 1075
Score = 32.0 bits (71), Expect = 2.4
Identities = 55/243 (22%), Positives = 93/243 (38%), Gaps = 38/243 (15%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
E+ + K SE G+ G+ A +G F+++V G G++ D L+EV
Sbjct: 550 EIVVAHVSKFSENSGL---GISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEV 602
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGRER--PGEQSEVAQLIQQTLEQERWQREMME 610
+G +L+G ++L+ V + R P QSE+ L + E+ E
Sbjct: 603 NGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL-------DLCDIELTE 655
Query: 611 QRYAQYGE--DDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLV 668
+ + GE ET ED L+ T G LA E + +++E
Sbjct: 656 KPHVDLGEFIGSSET------EDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKG 709
Query: 669 HKFKELQIKHAVTEAEIQQLKRKL--QSLEQEKGRW------------RVEKAQLEQSVE 714
F L + + A + R L + ++ GR +E + LE++VE
Sbjct: 710 LGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVE 769
Query: 715 ENK 717
K
Sbjct: 770 ALK 772
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 68.6 bits (166), Expect = 2e-11
Identities = 68/213 (31%), Positives = 102/213 (47%), Gaps = 25/213 (11%)
Query: 385 EDFSEADLVD--VSAYSGLGEDSAGSALEEDDEDDEEDGEPPYE-PESGCV-----EIP- 435
E F DL++ V+ ++ A S E +++ D + P+ PE G IP
Sbjct: 890 EPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPN 949
Query: 436 GLSEEEDPAPSRK----IHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVER 491
GL E DP R I + +P + DY+ + + E R E
Sbjct: 950 GLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHL-----LRENTELAQPLRKEP 1004
Query: 492 LELFPVELEKDSEGLGISIIGM-GAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
E+ V L+K + G+G+SI+ GAG D KLGI+VK+V +GGAA DGR+ D L+
Sbjct: 1005 -EIITVTLKKQN-GMGLSIVAAKGAGQD----KLGIYVKSVVKGGAADVDGRLAAGDQLL 1058
Query: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRE 583
VDG SLVG++Q AA ++ T V + ++
Sbjct: 1059 SVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1091
Score = 35.8 bits (81), Expect = 0.16
Identities = 73/338 (21%), Positives = 117/338 (34%), Gaps = 27/338 (7%)
Query: 163 KEAAARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDADAVSPT-VSQLSAVFEKADSR 221
+E A +L R DRK D + N S+ LD+ S ++ S A +
Sbjct: 1279 REDKAYQLERHRIEAAMDRKSDSDMWINQSSS----LDSSTSSQEHLNHSSKSVTPASTL 1334
Query: 222 TGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAP--SGDAPAEKERCPAGQQPP 279
T GPG + VS+ R PPPPPPP +GD P P
Sbjct: 1335 T--KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPS 1392
Query: 280 QHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAA 339
+++ E RK E E E A E + + G +
Sbjct: 1393 ANQIGLPSAQVAAAERRK----REEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSL 1448
Query: 340 SPAPEEP-KAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAY 398
+PAP P AQ ++ + + P+ V P P + E + + ++S+
Sbjct: 1449 NPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTI-ERRDLQYITVSKEELSSG 1507
Query: 399 SGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPS-----RKIHFS- 452
L D + D ++ E + + + EI L + D + RK+
Sbjct: 1508 DSLSPD----PWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEW 1563
Query: 453 --TAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKR 488
+Q +D + ++DVD M E E+R
Sbjct: 1564 QFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERR 1601
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 68.6 bits (166), Expect = 2e-11
Identities = 68/213 (31%), Positives = 102/213 (47%), Gaps = 25/213 (11%)
Query: 385 EDFSEADLVD--VSAYSGLGEDSAGSALEEDDEDDEEDGEPPYE-PESGCV-----EIP- 435
E F DL++ V+ ++ A S E +++ D + P+ PE G IP
Sbjct: 891 EPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPN 950
Query: 436 GLSEEEDPAPSRK----IHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVER 491
GL E DP R I + +P + DY+ + + E R E
Sbjct: 951 GLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHL-----LRENTELAQPLRKEP 1005
Query: 492 LELFPVELEKDSEGLGISIIGM-GAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
E+ V L+K + G+G+SI+ GAG D KLGI+VK+V +GGAA DGR+ D L+
Sbjct: 1006 -EIITVTLKKQN-GMGLSIVAAKGAGQD----KLGIYVKSVVKGGAADVDGRLAAGDQLL 1059
Query: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRE 583
VDG SLVG++Q AA ++ T V + ++
Sbjct: 1060 SVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1092
Score = 35.8 bits (81), Expect = 0.16
Identities = 73/338 (21%), Positives = 117/338 (34%), Gaps = 27/338 (7%)
Query: 163 KEAAARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDADAVSPT-VSQLSAVFEKADSR 221
+E A +L R DRK D + N S+ LD+ S ++ S A +
Sbjct: 1280 REDKAYQLERHRIEAAMDRKSDSDMWINQSSS----LDSSTSSQEHLNHSSKSVTPASTL 1335
Query: 222 TGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAP--SGDAPAEKERCPAGQQPP 279
T GPG + VS+ R PPPPPPP +GD P P
Sbjct: 1336 T--KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPS 1393
Query: 280 QHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAA 339
+++ E RK E E E A E + + G +
Sbjct: 1394 ANQIGLPSAQVAAAERRK----REEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSL 1449
Query: 340 SPAPEEP-KAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAY 398
+PAP P AQ ++ + + P+ V P P + E + + ++S+
Sbjct: 1450 NPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTI-ERRDLQYITVSKEELSSG 1508
Query: 399 SGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPS-----RKIHFS- 452
L D + D ++ E + + + EI L + D + RK+
Sbjct: 1509 DSLSPD----PWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEW 1564
Query: 453 --TAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKR 488
+Q +D + ++DVD M E E+R
Sbjct: 1565 QFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERR 1602
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 68.6 bits (166), Expect = 2e-11
Identities = 68/213 (31%), Positives = 102/213 (47%), Gaps = 25/213 (11%)
Query: 385 EDFSEADLVD--VSAYSGLGEDSAGSALEEDDEDDEEDGEPPYE-PESGCV-----EIP- 435
E F DL++ V+ ++ A S E +++ D + P+ PE G IP
Sbjct: 875 EPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPN 934
Query: 436 GLSEEEDPAPSRK----IHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVER 491
GL E DP R I + +P + DY+ + + E R E
Sbjct: 935 GLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYESHL-----LRENTELAQPLRKEP 989
Query: 492 LELFPVELEKDSEGLGISIIGM-GAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
E+ V L+K + G+G+SI+ GAG D KLGI+VK+V +GGAA DGR+ D L+
Sbjct: 990 -EIITVTLKKQN-GMGLSIVAAKGAGQD----KLGIYVKSVVKGGAADVDGRLAAGDQLL 1043
Query: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRE 583
VDG SLVG++Q AA ++ T V + ++
Sbjct: 1044 SVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQ 1076
Score = 35.8 bits (81), Expect = 0.16
Identities = 73/338 (21%), Positives = 117/338 (34%), Gaps = 27/338 (7%)
Query: 163 KEAAARRLLRQERAGLQDRKLDVVVRFNGSTEALDKLDADAVSPT-VSQLSAVFEKADSR 221
+E A +L R DRK D + N S+ LD+ S ++ S A +
Sbjct: 1264 REDKAYQLERHRIEAAMDRKSDSDMWINQSSS----LDSSTSSQEHLNHSSKSVTPASTL 1319
Query: 222 TGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAP--SGDAPAEKERCPAGQQPP 279
T GPG + VS+ R PPPPPPP +GD P P
Sbjct: 1320 T--KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPS 1377
Query: 280 QHRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAA 339
+++ E RK E E E A E + + G +
Sbjct: 1378 ANQIGLPSAQVAAAERRK----REEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSL 1433
Query: 340 SPAPEEP-KAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAY 398
+PAP P AQ ++ + + P+ V P P + E + + ++S+
Sbjct: 1434 NPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTI-ERRDLQYITVSKEELSSG 1492
Query: 399 SGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPS-----RKIHFS- 452
L D + D ++ E + + + EI L + D + RK+
Sbjct: 1493 DSLSPD----PWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEW 1548
Query: 453 --TAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKR 488
+Q +D + ++DVD M E E+R
Sbjct: 1549 QFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERR 1586
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 68.6 bits (166), Expect = 2e-11
Identities = 37/98 (37%), Positives = 59/98 (60%), Gaps = 8/98 (8%)
Query: 490 ERLELFPVELEKDS-EGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDL 548
E LE+FPV+L+K + GLG+SI+G G+ G+F+ + +GGAA DGR+ D
Sbjct: 1527 ENLEIFPVDLQKKAGRGLGLSIVGKRNGS-------GVFISDIVKGGAADLDGRLIQGDQ 1579
Query: 549 LVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPG 586
++ V+G + +Q A++L+ +G V+ IGR R G
Sbjct: 1580 ILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAG 1617
Score = 66.2 bits (160), Expect = 1e-10
Identities = 35/93 (37%), Positives = 51/93 (54%), Gaps = 8/93 (8%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VEL D GLG I+G G+ V+T+ GG A RDGR+Q D ++++ GT+
Sbjct: 249 VELINDGSGLGFGIVGGKTS--------GVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQS 589
+ G+T A VLRN VR ++ R+ G+ S
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDIS 333
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 2/93 (2%)
Query: 493 ELFPVEL-EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVE 551
E + VEL KD + LGI I+G + G E GI+VK++ G AA+ +G IQVND +V
Sbjct: 362 ETYNVELVRKDGQSLGIRIVGYVGTSHTG-EASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 552 VDGTSLVGVTQSFAASVLRNTKGRVRFMIGRER 584
VDG ++ G VLRN V + R +
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK 453
Score = 60.1 bits (144), Expect = 8e-09
Identities = 54/190 (28%), Positives = 86/190 (45%), Gaps = 9/190 (4%)
Query: 403 EDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTA--PIQVFS 460
ED +G+ +ED + PES ++ ++ P+ K+ FS+ P+ S
Sbjct: 1344 EDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPT-KVSFSSQEIPLAPAS 1402
Query: 461 TYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMG 520
+Y + D D S + V E+ +E+ K GLG+SI+G G D
Sbjct: 1403 SYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI-IEISKGRSGLGLSIVG---GKDTP 1458
Query: 521 LEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMI 580
L I + V E GAA RDGR+ D ++EV+G L + A + LR T +VR ++
Sbjct: 1459 LN--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
Query: 581 GRERPGEQSE 590
R+ + E
Sbjct: 1517 YRDEAHYRDE 1526
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/119 (29%), Positives = 62/119 (52%), Gaps = 10/119 (8%)
Query: 466 DYDRRNEDVDPMAASAEYELEKRVERL--ELFPVELEKDSEGLGISIIGMGAGADMGLEK 523
D NE+ D A + ++ +R L EL +ELEKD GLG+S+ G + +
Sbjct: 1210 DDSDENEEED---AFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAG-----NKDRSR 1261
Query: 524 LGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGR 582
+ IFV + G A DGR+++ D L+E++ L G + A+++++ +V+ + R
Sbjct: 1262 MSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 48.1 bits (113), Expect = 3e-05
Identities = 30/103 (29%), Positives = 57/103 (55%), Gaps = 11/103 (10%)
Query: 475 DPMAASAEYELEKRVERLELFPVELEKD-SEGLGISIIGMGAGADMGLEKLGIFVKTVTE 533
DP ++ ++E R VE+ ++ S+ LGISI G G G+ +G + +F+ +
Sbjct: 1662 DPSQKNSGTDMEPRT-------VEINRELSDALGISIAG-GRGSPLG--DIPVFIAMIQA 1711
Query: 534 GGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRV 576
G A R +++V D +V ++G L G++ + ++L+N GR+
Sbjct: 1712 SGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRI 1754
Score = 33.1 bits (74), Expect = 1.1
Identities = 23/74 (31%), Positives = 36/74 (48%), Gaps = 2/74 (2%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VEL KD +GLG SI+ D + I ++++ G A R G + D LV V+
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDP--TRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744
Query: 557 LVGVTQSFAASVLR 570
L + + A +L+
Sbjct: 745 LDNTSLAEAVEILK 758
Score = 31.2 bits (69), Expect = 4.1
Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 6/75 (8%)
Query: 498 ELEKDSEGLGISIIGMGAGADM--GLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGT 555
EL+K S+ L I + +G D G ++ ++ GG G +Q D L+EV+G
Sbjct: 555 ELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGM 610
Query: 556 SLVGVTQSFAASVLR 570
L G ++ A S L+
Sbjct: 611 QLYGKSRREAVSFLK 625
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 67.8 bits (164), Expect = 4e-11
Identities = 71/266 (26%), Positives = 115/266 (43%), Gaps = 26/266 (9%)
Query: 405 SAGSALEEDDEDDEEDGEPP-------YEPESGCVEI-----PGLSEEE-DPAPSRKIHF 451
SAG + D + E+G P ++ E+G + P L E D +I
Sbjct: 237 SAGCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPK 296
Query: 452 STAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISII 511
+ AP+ T SN D+R + R E ++ +EL K+S+GLGI +
Sbjct: 297 TDAPL----TTSN---DKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVS 349
Query: 512 GMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRN 571
G G G+ I V V EGGAAHRDGR+ + D L+ ++G LVG++ A ++LR+
Sbjct: 350 G-GRGSKRSPH--AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRS 406
Query: 572 TKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDED 631
G V+ ++ + ++ +L ++L E + ED E GE
Sbjct: 407 ATGMVQLVVA-SKENSAEDLLRLTSKSLPDLTSSVEDVSS--WTDNEDQEADGEEDEGTS 463
Query: 632 EELSPTFPGGEMAIEVFELAENEDAL 657
+ PG + +V E++ L
Sbjct: 464 SSVQRAMPGTDEPQDVCGAEESKGNL 489
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/105 (32%), Positives = 53/105 (50%), Gaps = 20/105 (19%)
Query: 474 VDPMAASAEYELEKRVER-LELFPVE----------------LEKDSEGLGISIIGMGAG 516
+D +AS EY + K+ R L VE ++ +GLG SI G G
Sbjct: 548 LDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAG---G 604
Query: 517 ADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVT 561
D ++GIFVKT+ G+A DGR++ D +++V+G + G+T
Sbjct: 605 RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLT 649
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VE+ K S GLG+S+ G G + G L +K V +GGAA + G I+ D ++ ++G
Sbjct: 2751 VEVLKTSAGLGLSLDG-GKSSVTGDGPL--VIKRVYKGGAAEQAGIIEAGDEILAINGKP 2807
Query: 557 LVGVTQSFAASVLRNT-KGRVRFMIGRER 584
LVG+ A +++++ +G V+ +I + R
Sbjct: 2808 LVGLMHFDAWNIMKSVPEGPVQLLIRKHR 2836
Score = 39.7 bits (91), Expect = 0.011
Identities = 32/95 (33%), Positives = 44/95 (46%), Gaps = 9/95 (9%)
Query: 479 ASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAH 538
A A+ E E+ V F V K+ GLG S+ G G D+ E I V V GAA
Sbjct: 2610 AKAQSENEEDV----CFIVLNRKEGSGLGFSVAG---GTDV--EPKSITVHRVFSQGAAS 2660
Query: 539 RDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTK 573
++G + D L+ V+G SL G+ VL +
Sbjct: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQ 2695
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++F VEL K+ LGIS+ G G + + GI+VK V GAA DGRI D ++ V
Sbjct: 1174 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1230
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGR-ERPGEQSEVAQLIQQTLEQERWQREMMEQ 611
+G SL G T A LRNT V ++ + + P + V Q TL + Q + E+
Sbjct: 1231 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1290
Score = 59.7 bits (143), Expect = 1e-08
Identities = 46/153 (30%), Positives = 77/153 (50%), Gaps = 11/153 (7%)
Query: 456 IQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSE-GLGISIIGMG 514
+Q+ + SN+D +D+D + + + ER E+ V L+KD++ GLG IIG
Sbjct: 869 LQMRARQSNQDA----QDIDVL--HKRWSIVSSPER-EITLVNLKKDAKYGLGFQIIG-- 919
Query: 515 AGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKG 574
G MG LGIF+ +V GG A DG ++ D L+ V+ SL GV+ A +L+N
Sbjct: 920 -GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPE 978
Query: 575 RVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
V +I + + + + T E + + ++
Sbjct: 979 DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1011
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
E+ +P+ K H P S D + + + + + + + + V F V+L
Sbjct: 1259 EKGQSPTSKEHVPVTPQCTLS-----DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL 1313
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
K+S GLG S + + VK + G A G+I V D++++V+G SL G
Sbjct: 1314 FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKG 1373
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
++Q S LR T V ++ R PG E+
Sbjct: 1374 LSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1405
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++F VEL K+ LGIS+ G G + + GI+VK V GAA DGRI D ++ V
Sbjct: 1365 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1421
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGR-ERPGEQSEVAQLIQQTLEQERWQREMMEQ 611
+G SL G T A LRNT V ++ + + P + V Q TL + Q + E+
Sbjct: 1422 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1481
Score = 60.5 bits (145), Expect = 6e-09
Identities = 66/291 (22%), Positives = 122/291 (41%), Gaps = 30/291 (10%)
Query: 321 AEVTVHAALENGSTVATAASPAPEEPK--AQAAPEKEAAAVAPPERGV-GNGRAPDVAPE 377
+E++++ L+N S + E+P+ +++ + A++ P + V N P
Sbjct: 938 SELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVA 997
Query: 378 EVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGL 437
E+ S +D ++ + L + ++L E + +E +S +E PG
Sbjct: 998 ELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRK------HESDSSSIEDPGQ 1051
Query: 438 SEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPV 497
+ + S S+ + DV + + ER E+ V
Sbjct: 1052 A------------YVLGMTMHSSGNSSSQVPLKENDV----LHKRWSIVSSPER-EITLV 1094
Query: 498 ELEKDSE-GLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
L+KD++ GLG IIG G MG LGIF+ +V GG A DG ++ D L+ V+ S
Sbjct: 1095 NLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 1151
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
L GV+ A +L+N V +I + + + + T E + + ++
Sbjct: 1152 LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1202
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
E+ +P+ K H P S D + + + + + + + + V F V+L
Sbjct: 1450 EKGQSPTSKEHVPVTPQCTLS-----DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL 1504
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
K+S GLG S + + VK + G A G+I V D++++V+G SL G
Sbjct: 1505 FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKG 1564
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
++Q S LR T V ++ R PG E+
Sbjct: 1565 LSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1596
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/120 (35%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++F VEL K+ LGIS+ G G + + GI+VK V GAA DGRI D ++ V
Sbjct: 1346 DIFEVELAKNDNSLGISVTG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1402
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGR-ERPGEQSEVAQLIQQTLEQERWQREMMEQ 611
+G SL G T A LRNT V ++ + + P + V Q TL + Q + E+
Sbjct: 1403 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1462
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 4/116 (3%)
Query: 493 ELFPVELEKDSE-GLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVE 551
E+ V L+KD++ GLG IIG G MG LGIF+ +V GG A DG ++ D L+
Sbjct: 1071 EITLVNLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1127
Query: 552 VDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
V+ SL GV+ A +L+N V +I + + + + T E + + ++
Sbjct: 1128 VNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1183
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
E+ +P+ K H P S D + + + + + + + + V F V+L
Sbjct: 1431 EKGQSPTSKEHVPVTPQCTLS-----DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL 1485
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
K+S GLG S + + VK + G A G+I V D++++V+G SL G
Sbjct: 1486 FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKG 1545
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
++Q S LR T V ++ R PG E+
Sbjct: 1546 LSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1577
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 62.8 bits (151), Expect = 1e-09
Identities = 61/213 (28%), Positives = 98/213 (46%), Gaps = 38/213 (17%)
Query: 377 EEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPG 436
E++ +S+K ++ + S Y + S SA + PP + +S +P
Sbjct: 367 EQLSQSEKNNYYSSRFSPDSQY--IDNRSVNSAGLHTVQRAPRLNHPPEQIDSHS-RLPH 423
Query: 437 LSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFP 496
+ PS ++AP VFST S+ Y +K +RL
Sbjct: 424 SAHPSGKPPSAP---ASAPQNVFST----------------TVSSGYNTKKIGKRLN--- 461
Query: 497 VELEKDSEGLGISI----IGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++L+K +EGLG SI + +G A I+VK + GAA +DGR++ D L+EV
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAP-------IYVKNILPRGAAIQDGRLKAGDRLIEV 514
Query: 553 DGTSLVGVTQSFAASVLRNTK--GRVRFMIGRE 583
+G LVG +Q S+LR+TK G V ++ R+
Sbjct: 515 NGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547
Score = 62.4 bits (150), Expect = 2e-09
Identities = 37/84 (44%), Positives = 52/84 (61%), Gaps = 5/84 (5%)
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
+ S GLG+S+ G + + LGIFVK++ GGAA +DGR++VND L+ V+G SL+G
Sbjct: 595 DSGSAGLGVSVKGNRSKENHA--DLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
Query: 560 VTQSFAASVLR---NTKGRVRFMI 580
T A LR +T+G R MI
Sbjct: 653 KTNQDAMETLRRSMSTEGNKRGMI 676
Score = 33.5 bits (75), Expect = 0.82
Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 3/61 (4%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VE+ D LGI ++ A G LG+ VK + +GG A + + ND +V ++
Sbjct: 275 VEVPNDGGPLGIHVVPFSA---RGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 557 L 557
L
Sbjct: 332 L 332
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 62.4 bits (150), Expect = 2e-09
Identities = 42/122 (34%), Positives = 61/122 (50%), Gaps = 3/122 (2%)
Query: 493 ELFPVELEKDSEGLGISIIGM--GAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLV 550
++F VEL K+ LGIS+ + G + + GI+VK V GAA DGRI D ++
Sbjct: 1365 DIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1424
Query: 551 EVDGTSLVGVTQSFAASVLRNTKGRVRFMIGR-ERPGEQSEVAQLIQQTLEQERWQREMM 609
V+G SL G T A LRNT V ++ + + P + V Q TL + Q +
Sbjct: 1425 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGP 1484
Query: 610 EQ 611
E+
Sbjct: 1485 EK 1486
Score = 60.5 bits (145), Expect = 6e-09
Identities = 66/291 (22%), Positives = 122/291 (41%), Gaps = 30/291 (10%)
Query: 321 AEVTVHAALENGSTVATAASPAPEEPK--AQAAPEKEAAAVAPPERGV-GNGRAPDVAPE 377
+E++++ L+N S + E+P+ +++ + A++ P + V N P
Sbjct: 938 SELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVA 997
Query: 378 EVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEEDGEPPYEPESGCVEIPGL 437
E+ S +D ++ + L + ++L E + +E +S +E PG
Sbjct: 998 ELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRK------HESDSSSIEDPGQ 1051
Query: 438 SEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPV 497
+ + S S+ + DV + + ER E+ V
Sbjct: 1052 A------------YVLGMTMHSSGNSSSQVPLKENDV----LHKRWSIVSSPER-EITLV 1094
Query: 498 ELEKDSE-GLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
L+KD++ GLG IIG G MG LGIF+ +V GG A DG ++ D L+ V+ S
Sbjct: 1095 NLKKDAKYGLGFQIIG---GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 1151
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
L GV+ A +L+N V +I + + + + T E + + ++
Sbjct: 1152 LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1202
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 5/152 (3%)
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
E+ +P+ K H P S D + + + + + + + + V F V+L
Sbjct: 1455 EKGQSPTSKEHVPVTPQCTLS-----DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKL 1509
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
K+S GLG S + + VK + G A G+I V D++++V+G SL G
Sbjct: 1510 FKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKG 1569
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
++Q S LR T V ++ R PG E+
Sbjct: 1570 LSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1601
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 62.4 bits (150), Expect = 2e-09
Identities = 161/715 (22%), Positives = 263/715 (36%), Gaps = 100/715 (13%)
Query: 143 RLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQDRKLDVV--------VRFNGSTE 194
+LQE F G +EA + + A + KL+ +R + +
Sbjct: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
Query: 195 ALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVNSKLVSKRSRVFQPP 254
L+A+ V + +A + R+ L RG GL RA P
Sbjct: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS----------------PAP 1454
Query: 255 PPPPPAPSGDAPAEKE----------RCPAGQQPPQHRVA--PARPPPKPREVRKIKPVE 302
P P +P+ DAPAE C G QPP A PA P P VR
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF 1514
Query: 303 VEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVAPP 362
++E ++ E Q E + +A S A + KA A E+ +V
Sbjct: 1515 LQELRSAQRERDELRT-QTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
Query: 363 ERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEEDGE 422
GV A + E V S++E + D V S +S A +E + + E
Sbjct: 1574 LSGVQAELA--LQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKAN-E 1630
Query: 423 PPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAE 482
E + L E D + SR T +++ + R + A A+
Sbjct: 1631 TKLEGDKR-----RLKEVLDASESR-----TVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
Query: 483 YELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIF---VKTVTEGGA--- 536
L+ RV+ L+ + E + L +++ + E G V+ +TE A
Sbjct: 1681 -ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSS 1739
Query: 537 ----AHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVA 592
+ RD + + L + V + AA + + +G + + EVA
Sbjct: 1740 ASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVA 1799
Query: 593 QLIQQTLEQE---RWQREMMEQRYAQYGEDDE-ETGEYATDEDEELSPTFPGGEMAIEVF 648
L Q +E E + RE++ QR Q GE T + DE L + A+
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQR--QEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
Query: 649 ELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQ 708
E + E S + +E +++ L+R L +E+EK R + +
Sbjct: 1858 EAEKREVERSALRLEKDRVA-------------------LRRTLDKVEREKLRSHEDTVR 1898
Query: 709 LEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQK 768
L + E EAQ +++ +AQ LE+ +S A+ + QQ+
Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQ-------RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
Query: 769 -----EIEFLKKETAQ-RRVLEESELARKEEMDKLLDKISELEGNL-QTLRNSNS 816
E+E L+ AQ R LE E A ++ + L +++S L+G L Q LR S++
Sbjct: 1952 LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/237 (26%), Positives = 103/237 (43%), Gaps = 32/237 (13%)
Query: 594 LIQQTLEQERWQREMMEQRYAQYGEDDE---ETGEYATDED------EELSPTFPGGEMA 644
L ++ LE +R RE E R Q E E GE A + + EEL E
Sbjct: 1173 LRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE 1232
Query: 645 IEVFELAEN---------EDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSL 695
+LA E+A + V E +L +E++ E+Q+L+R+++ L
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
Query: 696 EQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKY 755
+ E R E A+L+ + ER EK E++ + + L + +A + + ++
Sbjct: 1293 DSENTRLGRELAELQGRLALG-ERAEK------ESRRETLGLRQRLLKGEASLEVMRQEL 1345
Query: 756 SKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLR 812
A+R + Q++E EF T +RR+L E AR E + LD LE L+ R
Sbjct: 1346 QVAQRKL---QEQEGEF---RTRERRLLGSLEEARGTEKQQ-LDHARGLELKLEAAR 1395
Score = 44.7 bits (104), Expect = 4e-04
Identities = 51/199 (25%), Positives = 91/199 (45%), Gaps = 11/199 (5%)
Query: 595 IQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENE 654
+++ L + QR+M++ A+ E T A + ELS T E A +
Sbjct: 685 VREALSRATLQRDMLQAEKAEVAE--ALTKAEAGRVELELSMTKLRAEEA-------SLQ 735
Query: 655 DALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVE 714
D+LS + E L +L A E E L+ + + EQE R E+ +LE+
Sbjct: 736 DSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRL 795
Query: 715 ENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLK 774
E + + LEG A+ +A+++ L + + L+ + ++ R + +Q E+E +
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ-ELEQAR 854
Query: 775 KETAQRRVLEESELARKEE 793
+E AQR+V AR++E
Sbjct: 855 RE-AQRQVEALERAAREKE 872
Score = 43.9 bits (102), Expect = 6e-04
Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 31/238 (13%)
Query: 581 GRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYG-EDDEETGEYATDEDEELSPTFP 639
GR+R EQ A + ++ EQER + +EQ A+ G E E A + E+ PT
Sbjct: 771 GRQRQAEQE--ATVARE--EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLR 826
Query: 640 GGEMAIEVF------ELAENEDALSPVDMEPEKLVHKFKE-------LQIKHAVTEAEIQ 686
++ +L+ E L E ++ V + L +HA ++
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV 886
Query: 687 QLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEG----YWGEAQSLCQAVDE--- 739
+R+ ++L +E R R+EK LE S+ E + ++ +LE E Q+L A +
Sbjct: 887 AAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG 946
Query: 740 HLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKL 797
L + Q A + K S K L+ + ++ E + L E A +E++ +L
Sbjct: 947 ELAGLRQQIIATQEKASLDKELMAQ------KLVQAEREAQASLREQRAAHEEDLQRL 998
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/149 (22%), Positives = 70/149 (46%), Gaps = 11/149 (7%)
Query: 663 EPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEK 722
E E+L E ++ E ++ ++ ++LEQ+ R E++QL++ + + ++
Sbjct: 786 EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Query: 723 LEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRV 782
E Q +++ RE Q Q +ALER + + L K++ ++ + E R +
Sbjct: 846 RE----------QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 783 LEESELARKEEMDKLLDKISELEGNLQTL 811
EE+ R E+ + L + E++ L L
Sbjct: 896 SEEATRLRLEK-EALEGSLFEVQRQLAQL 923
Score = 40.8 bits (94), Expect = 0.005
Identities = 45/255 (17%), Positives = 101/255 (39%), Gaps = 41/255 (16%)
Query: 580 IGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFP 639
+ +++ E + + +Q E+ R QR+ +E+ +D +L
Sbjct: 614 VAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL-- 671
Query: 640 GGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQ------------ 687
G+ ++ EL E +ALS ++ + L + ++ ++ A+T+AE +
Sbjct: 672 EGKRSVLAKELVEVREALSRATLQRDML--QAEKAEVAEALTKAEAGRVELELSMTKLRA 729
Query: 688 -------------------------LKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEK 722
L R + LE+EK + + Q EQ +E E+
Sbjct: 730 EEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQER 789
Query: 723 LEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRV 782
LE E + Q ++ LR + +ALE++ + Q++ + ++ + + +
Sbjct: 790 LEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 783 LEESELARKEEMDKL 797
LE++ + +++ L
Sbjct: 850 LEQARREAQRQVEAL 864
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/175 (22%), Positives = 74/175 (42%), Gaps = 12/175 (6%)
Query: 649 ELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQ 708
+L+++E ++ + ++L K H + E+Q+L+ + L +EK
Sbjct: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Query: 709 LEQSVEENKERMEKLEGYWGEAQSLCQAVDEH-----------LRETQAQYQALERKYSK 757
+Q EE ++ EKL+ E + ++E RE + ++ LE+ K
Sbjct: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
Query: 758 AKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLR 812
L K+ + E L + T QR +L+ + E + K ELE ++ LR
Sbjct: 675 RSVLAKELVEVR-EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Score = 30.8 bits (68), Expect = 5.3
Identities = 55/227 (24%), Positives = 91/227 (40%), Gaps = 32/227 (14%)
Query: 588 QSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDE-----ETGEYATDEDEELSPTFPGGE 642
Q E+++ ++ L Q R +R+ + +Y E E E GE T E L
Sbjct: 87 QQELSR-VEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV------R 139
Query: 643 MAIEVFELAENEDA--------LSPVDMEPEKLVHKF--KELQIKHAVTEAEIQQLKRKL 692
++E+ + E A +LV + K LQ K +E E QQL +
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELE-QQLLERS 198
Query: 693 QSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALE 752
LEQ++ R LE ++ +E ++ + SL Q V+ LRE Q +
Sbjct: 199 GELEQQRLRDTEHSQDLESALIRLEEEQQR-------SASLAQ-VNAMLREQLDQAGSAN 250
Query: 753 RKYSK-AKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLL 798
+ S+ +++ D+ + E +E A RR E E +LL
Sbjct: 251 QALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLL 297
Score = 30.8 bits (68), Expect = 5.3
Identities = 52/252 (20%), Positives = 98/252 (38%), Gaps = 27/252 (10%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
R+ Q + + + R R E+ A + ++ E A D ++
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREA 1156
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
E L E DA + E + K +E Q V E +L+R L +E+
Sbjct: 1157 EELRTQLRLLE--DARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREA 1214
Query: 702 WRVEKAQLEQSVEE-----------NKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQA 750
R +L +V++ N+++ +KL EA++ AV + E + Q
Sbjct: 1215 LRRSNEELRSAVKKAESERISLKLANEDKEQKL-ALLEEART---AVGKEAGELRTGLQE 1270
Query: 751 LERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEE-------SELARKEEMDKLL---DK 800
+ER +A+R +++ +++ + T R L E E A KE + L +
Sbjct: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQR 1330
Query: 801 ISELEGNLQTLR 812
+ + E +L+ +R
Sbjct: 1331 LLKGEASLEVMR 1342
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 61.6 bits (148), Expect = 3e-09
Identities = 53/231 (22%), Positives = 113/231 (48%), Gaps = 11/231 (4%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
RER + E +++++ E+ + Q E M+++ + E +E+ E E+ +
Sbjct: 592 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
E E L E ++ L E EK+ + K + + + E E ++++K Q EQEK
Sbjct: 652 EKMWEQQRLPEQKEKL----WEHEKMQEQEKMQEQEEKIWEQE--KMEKKTQ--EQEKKT 703
Query: 702 WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRL 761
W EK + E+S+ E +++M + E E + Q +E ++E + + E K + +
Sbjct: 704 WDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE- 762
Query: 762 IKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLR 812
K ++Q+ + K++ + ++E E ++E +K+ D+ ++ G + +R
Sbjct: 763 -KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE-EKMRDQEEKMRGQEEKMR 811
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/212 (23%), Positives = 92/212 (43%), Gaps = 12/212 (5%)
Query: 600 EQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSP 659
E + W++E + Q D EE E T E E+ T+ E E + E E +
Sbjct: 543 EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK--KTWDQEEKMREEERMREREKKMRE 600
Query: 660 VDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVE--ENK 717
+ + K +E + K E ++ + + K+Q EQE+ W E+ EQ + E +
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ--EQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 718 ERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKET 777
E+ E W + Q + E + + +E+K + ++ D Q+K E
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD-QEKMREEESMRE 717
Query: 778 AQRRVLEESELARKEEMDKLLDKISELEGNLQ 809
++++ EE E+ R++E +K+ E E +Q
Sbjct: 718 REKKMREEEEMMREQE-----EKMQEQEEKMQ 744
Score = 48.9 bits (115), Expect = 2e-05
Identities = 59/275 (21%), Positives = 121/275 (44%), Gaps = 34/275 (12%)
Query: 524 LGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRE 583
L ++ T+T ++ +Q L E + + + L+ R +F++ +
Sbjct: 211 LELYRNTITNEELKKKNAELQEKLPLAESEKSEI-----QLNVKELKRKLERAKFLLPQV 265
Query: 584 RPGE-QSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGE 642
+ Q E+ + ++ EQE+ R+ E+ + Q E+ G+ E++
Sbjct: 266 QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK---------- 315
Query: 643 MAIEVFELAENEDALSPVDMEPEKLVHKFKEL-QIKHAVTEAEIQQLKRKLQSLEQEKGR 701
M + L E E L E EK + + KEL + + + E E + +++ + EQE+
Sbjct: 316 MWRQEKRLREQEKELR----EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 702 WRVEKAQLEQSV---EENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKA 758
WR E+ EQ E+ ++ ++ E W + DE LRE + + + E+ + +
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQEERMWEQ--------DERLREKEERMREQEKMWEQV 423
Query: 759 KRLIKDYQQKEIEFLKKETAQRRVLEESELARKEE 793
+++ ++ + +E E KK Q ++E E R+ E
Sbjct: 424 EKMREEKKMQEQE--KKTRDQEEKMQEEERIRERE 456
Score = 43.9 bits (102), Expect = 6e-04
Identities = 49/239 (20%), Positives = 111/239 (46%), Gaps = 22/239 (9%)
Query: 575 RVRFMIGRERPGEQS---EVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDED 631
R+R G+ R E+ + +L +Q E ++E+ EQ+ + E+ + E E
Sbjct: 301 RLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQ 360
Query: 632 EELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRK 691
EE +M + ++ E+ L + + + K ++ + + + +++ + +
Sbjct: 361 EE--------KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 412
Query: 692 LQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQAL 751
++ EQEK +VEK + E+ ++E +++ E E +E +RE + + +
Sbjct: 413 MR--EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE--------EERIREREKKMREE 462
Query: 752 ERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESE-LARKEEMDKLLDKISELEGNLQ 809
E + + ++ ++ E +KE Q+R+ E+ E L +E+M + +KI E E ++
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Score = 43.5 bits (101), Expect = 8e-04
Identities = 40/224 (17%), Positives = 103/224 (45%), Gaps = 6/224 (2%)
Query: 587 EQSEVAQLIQQTL---EQERWQREMMEQRYAQYGEDD--EETGEYATDEDEELSPTFPGG 641
EQ E Q ++ + E++ WQ++ + ++ + E + +E E +++E++
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
+++ + + + + EK+ + +++ + E + Q+ ++K ++EK R
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD-QEEKMR 586
Query: 702 WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRL 761
+ E+ + E +E M + E E + Q +E + E + + Q E K + +
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 762 IKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELE 805
+ + ++K E + + ++ E ++ +E+M + +KI E E
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQE 690
Score = 38.9 bits (89), Expect = 0.019
Identities = 40/218 (18%), Positives = 96/218 (44%), Gaps = 19/218 (8%)
Query: 597 QTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDA 656
Q E++ W++E ME++ E +++T + +EE M ++ E E+
Sbjct: 680 QEQEEKIWEQEKMEKKTQ---EQEKKTWDQEKMREEE--------SMREREKKMREEEEM 728
Query: 657 LSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKL---QSLEQEKGR-WRVEKAQLEQS 712
+ + + ++ K +E + + E ++ + + K+ Q L ++K + W EK Q ++
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 713 VEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQK---- 768
+ E +E+M E + + +E +R + + E K + + ++K
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 769 EIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEG 806
E + +K Q + E E + + +K+ ++ ++ G
Sbjct: 849 EEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRG 886
Score = 36.2 bits (82), Expect = 0.13
Identities = 39/189 (20%), Positives = 88/189 (46%), Gaps = 12/189 (6%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIE 646
E+ + +++ ++ R + EMM ++ + E +E+ E + E+ + E E
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766
Query: 647 VFELAENEDALSPVDMEPEKLVHKFK--ELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRV 704
L E ++ L E EK+ + K E + K E +++ + K++ ++EK R +
Sbjct: 767 QQRLPEQKEKL----WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG-QEEKMRGQE 821
Query: 705 EK--AQLEQSVEENKERMEKLEGYWGEAQSL---CQAVDEHLRETQAQYQALERKYSKAK 759
EK Q E+ + ++ + E WG+ + + Q +E +RE + + + E K + +
Sbjct: 822 EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQE 881
Query: 760 RLIKDYQQK 768
++ ++K
Sbjct: 882 EKMRGQEEK 890
Score = 32.7 bits (73), Expect = 1.4
Identities = 30/145 (20%), Positives = 64/145 (44%), Gaps = 15/145 (10%)
Query: 666 KLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEG 725
+L + +H + I++L ++ +L E R + +L++ +N E EKL
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKK---KNAELQEKLP- 235
Query: 726 YWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEI-EFLKKETAQRRVLE 784
+ E Q + L+RK +AK L+ Q + E + ++ + R E
Sbjct: 236 ----------LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE 285
Query: 785 ESELARKEEMDKLLDKISELEGNLQ 809
+ ++E+M + +++ E EG ++
Sbjct: 286 KKIRKQEEKMWRQEERLREQEGKMR 310
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 60.5 bits (145), Expect = 6e-09
Identities = 55/247 (22%), Positives = 120/247 (48%), Gaps = 12/247 (4%)
Query: 569 LRNTKGRVRFMIG--RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEY 626
+R +G+VR G RE+ G+ E +++ Q R Q M ++ Q GE +E+ GE
Sbjct: 152 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQ 211
Query: 627 ATD-EDEELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKE-----LQIKHAV 680
+ +E +M + ++ E E+ + + + +K + ++ + + +
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271
Query: 681 TEAEIQQLKRKLQSLEQEK-GRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDE 739
E E Q LK+K Q+ ++E+ G + + E+ + E +E+M + E E + +E
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331
Query: 740 HLRETQAQ-YQALERKYSKAKRL--IKDYQQKEIEFLKKETAQRRVLEESELARKEEMDK 796
+ E + Q ++ E+ + + +++ ++ QK+ E ++K+ Q R EE ++E+M K
Sbjct: 332 QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
Query: 797 LLDKISE 803
+++ E
Sbjct: 392 QEEQMGE 398
Score = 57.8 bits (138), Expect = 4e-08
Identities = 51/237 (21%), Positives = 108/237 (45%), Gaps = 15/237 (6%)
Query: 569 LRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYAT 628
+R +G+VR G+ R ++ +V + Q EQE RE Q Q G+ E+ G+
Sbjct: 68 VREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 629 DEDEELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQL 688
E + G++ + ++ E E + + + + + +E + + E ++++
Sbjct: 127 QEGQVREQE---GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 183
Query: 689 KRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQY 748
+ +++ E + G + + E+ + E +E+M+K E GE + + +E + E + Q
Sbjct: 184 EGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 749 QALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELE 805
Q E + QK+ E ++K+ Q R EE ++E+M K ++ + E
Sbjct: 244 QKQEEQV-----------QKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/161 (21%), Positives = 79/161 (49%), Gaps = 11/161 (6%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIE 646
+Q E + +QT EQE RE EQ Q E E E +++E++ G+ +
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQE-EQMREQEEQMREQEEQM------GKQEEQ 332
Query: 647 VFELAENE-DALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVE 705
++E E + + + E++ + +++Q + + +Q++++ + + +++ + R +
Sbjct: 333 MWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQ 392
Query: 706 KAQLEQSVE---ENKERMEKLEGYWGEAQSLCQAVDEHLRE 743
+ Q+ + E E KE+M + E GE + + +EH+ E
Sbjct: 393 EEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/205 (24%), Positives = 90/205 (43%), Gaps = 20/205 (9%)
Query: 583 ERPGEQSEVAQL----IQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTF 638
E+ GEQ E Q +Q+ EQ R Q E M ++ Q E +E+ + ++E
Sbjct: 234 EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGE 293
Query: 639 PGGEMAIEVFELAENEDALSPVD---MEPEKLVHKFKEL--QIKHAVTEAEIQQLKRKLQ 693
+M + ++ E E+ + + E E+ + K +E + K + E + Q K++ Q
Sbjct: 294 QEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQ 353
Query: 694 SLEQEKGRWRVEKA---------QLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRET 744
EQE+ + E+ + E+ + + +E+M K E GE + E +RE
Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413
Query: 745 QAQYQALERKYSKAKRLIKDYQQKE 769
+ Q E+K K+ +QKE
Sbjct: 414 EEQMG--EQKEQMRKQEEHMGEQKE 436
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 60.5 bits (145), Expect = 6e-09
Identities = 38/97 (39%), Positives = 58/97 (59%), Gaps = 11/97 (11%)
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
+ S GLG+S+ G + G + LGIF+K++ GGAA +DGR+++ND L+ V+G SL+G
Sbjct: 503 DSGSAGLGVSLKG-NKSRETGTD-LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 560 VTQSFAASVLR-------NTKGRVRFMIGR--ERPGE 587
+ A LR N +G ++ +I R ERP E
Sbjct: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPME 597
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/78 (38%), Positives = 47/78 (60%), Gaps = 5/78 (6%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLG-IFVKTVTEGGAAHRDGRIQVNDLLVEVDGT 555
++L+K EGLG +++ D + G IFVK + GAA +DGR+Q D ++EV+G
Sbjct: 384 IDLKKGPEGLGFTVVTR----DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
Query: 556 SLVGVTQSFAASVLRNTK 573
+ G TQ ++LR+TK
Sbjct: 440 DVTGRTQEELVAMLRSTK 457
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/74 (24%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VE+ + LGI ++ + + LG+F++ + + + R+G N+ +V+++
Sbjct: 204 VEISGEGGPLGIHVVPFFSSLSGRI--LGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
Query: 557 LVGVTQSFAASVLR 570
LV T + A V R
Sbjct: 262 LVDKTFAQAQDVFR 275
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 8/41 (19%)
Query: 256 PPPPAPSGDAPAEKERCPAGQQPPQHRVAPA-----RPPPK 291
PPPPAP P ++ P+ PPQH+ PA RP P+
Sbjct: 1043 PPPPAPQHKGPFRQDVPPS---PPQHQRMPAYQETGRPGPR 1080
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 60.5 bits (145), Expect = 6e-09
Identities = 38/97 (39%), Positives = 58/97 (59%), Gaps = 11/97 (11%)
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
+ S GLG+S+ G + G + LGIF+K++ GGAA +DGR+++ND L+ V+G SL+G
Sbjct: 503 DSGSAGLGVSLKG-NKSRETGTD-LGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLG 560
Query: 560 VTQSFAASVLR-------NTKGRVRFMIGR--ERPGE 587
+ A LR N +G ++ +I R ERP E
Sbjct: 561 KSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPME 597
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/78 (38%), Positives = 47/78 (60%), Gaps = 5/78 (6%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLG-IFVKTVTEGGAAHRDGRIQVNDLLVEVDGT 555
++L+K EGLG +++ D + G IFVK + GAA +DGR+Q D ++EV+G
Sbjct: 384 IDLKKGPEGLGFTVVTR----DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGR 439
Query: 556 SLVGVTQSFAASVLRNTK 573
+ G TQ ++LR+TK
Sbjct: 440 DVTGRTQEELVAMLRSTK 457
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/74 (24%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
VE+ + LGI ++ + + LG+F++ + + + R+G N+ +V+++
Sbjct: 204 VEISGEGGPLGIHVVPFFSSLSGRI--LGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261
Query: 557 LVGVTQSFAASVLR 570
LV T + A V R
Sbjct: 262 LVDKTFAQAQDVFR 275
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 8/41 (19%)
Query: 256 PPPPAPSGDAPAEKERCPAGQQPPQHRVAPA-----RPPPK 291
PPPPAP P ++ P+ PPQH+ PA RP P+
Sbjct: 1075 PPPPAPQHKGPFRQDVPPS---PPQHQRMPAYQETGRPGPR 1112
>gi|44890059 involucrin [Homo sapiens]
Length = 585
Score = 59.3 bits (142), Expect = 1e-08
Identities = 59/258 (22%), Positives = 125/258 (48%), Gaps = 25/258 (9%)
Query: 569 LRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYAT 628
L +G+++ + +E+ E E + LEQ+ Q + +EQ+ Q + +E+ G+
Sbjct: 286 LEQQEGQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKH 345
Query: 629 DEDEE---------LSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKF-KELQIKH 678
E +E + +++ +L + + ++ E +L H +E Q+KH
Sbjct: 346 LEQQEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLEEEEGQLKHLVQQEGQLKH 405
Query: 679 AV-TEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAV 737
V E +++Q +R+++ LEQ+ G+ + +EE + +++ LE G+ + Q V
Sbjct: 406 LVQQEGQLEQQERQVEHLEQQVGQLK--------HLEEQEGQLKHLEQQQGQLEVPEQQV 457
Query: 738 DE--HLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESE--LARKEE 793
+ +L + + Q + E++ + K L K Q+ ++E +++ Q + LE+ E L E+
Sbjct: 458 GQPKNLEQEEKQLELPEQQEGQVKHLEK--QEAQLELPEQQVGQPKHLEQQEKHLEHPEQ 515
Query: 794 MDKLLDKISELEGNLQTL 811
D L + + EG L+ L
Sbjct: 516 QDGQLKHLEQQEGQLKDL 533
Score = 47.0 bits (110), Expect = 7e-05
Identities = 52/231 (22%), Positives = 106/231 (45%), Gaps = 30/231 (12%)
Query: 600 EQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSP 659
EQ+ Q E+ EQ+ Q +++ G+ E +E P E EL E ++
Sbjct: 177 EQQEGQLELPEQQEGQLELPEQQEGQLELPEQQEGQLELP--EQQEGQLELPEQQEGQLE 234
Query: 660 VDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQ-------- 711
+ + E + ++ + + ++E + QLK LE ++G+ V + Q+ Q
Sbjct: 235 LPQQQEGQLELSEQQEGQLELSEQQEGQLKH----LEHQEGQLEVPEEQMGQLKYLEQQE 290
Query: 712 ----SVEENKERMEKLEGYWGEAQSLCQ--AVDEHLRETQAQYQALERKYSKAKRLIKDY 765
+++ +++ E E G+ + L Q +HL + + Q + LE + + K L +
Sbjct: 291 GQLKHLDQQEKQPELPEQQMGQLKHLEQQEGQPKHLEQQEGQLEQLEEQEGQLKHL--EQ 348
Query: 766 QQKEIEFLKKETAQ-----RRVLEESELARKEEMDKLLDKISELEGNLQTL 811
Q+ ++E L+ + Q ++VL+ +L +++ K L+ E EG L+ L
Sbjct: 349 QEGQLEHLEHQEGQLGLPEQQVLQLKQLEKQQGQPKHLE---EEEGQLKHL 396
Score = 34.3 bits (77), Expect = 0.48
Identities = 36/153 (23%), Positives = 69/153 (45%), Gaps = 18/153 (11%)
Query: 672 KELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENK------------ER 719
+ELQ +H E Q+ + Q L+QEK + QL + +EE K +R
Sbjct: 85 QELQQQHWEQHEEYQKAENPEQQLKQEKTQ---RDQQLNKQLEEEKKLLDQQLDQELVKR 141
Query: 720 MEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRL-IKDYQQKEIEFLKKETA 778
E+L + L + + HL+ + Q L+ + +L + + Q+ ++E +++
Sbjct: 142 DEQLGMKKEQLLELPEQQEGHLKHLEQQEGQLKHPEQQEGQLELPEQQEGQLELPEQQEG 201
Query: 779 QRRVLE--ESELARKEEMDKLLDKISELEGNLQ 809
Q + E E +L E+ + L+ + EG L+
Sbjct: 202 QLELPEQQEGQLELPEQQEGQLELPEQQEGQLE 234
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/306 (22%), Positives = 106/306 (34%), Gaps = 65/306 (21%)
Query: 342 APEEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGL 401
AP P+AQ E+E E + EE + S +E+ E +V + G+
Sbjct: 651 APWAPRAQKEEEEEEEGSPQEEE---EEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGV 707
Query: 402 GEDSAGSALEEDDEDDEED--------------------GEPPYEPESGCVEIPGLSEEE 441
D A + L E +EE+ G PY+ + + I +SEE
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE- 766
Query: 442 DPAPSRKIHFSTAPIQV-------------------------FSTYSNEDYDRRNE-DVD 475
PA + ++V + + N +
Sbjct: 767 GPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTIT 826
Query: 476 PMAASAEYELEKRVE---RLELFPVE------------LEKDSEGLGISIIGMGAGADMG 520
P+ +Y +R RL L P E L + GLG SI G
Sbjct: 827 PLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYR 886
Query: 521 LEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMI 580
GIFV + EGGAAHR G +QV D ++ ++G + A S+L + ++
Sbjct: 887 AGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Query: 581 GRERPG 586
RE G
Sbjct: 947 EREAGG 952
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/408 (22%), Positives = 145/408 (35%), Gaps = 82/408 (20%)
Query: 260 APSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIK-PVEVEESGESEAESAPGEV 318
AP GD AE+ + R R P P E++ +K +E S + G
Sbjct: 453 APIGDEDAEEAAA-------EKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSP 505
Query: 319 IQAEVTVHAALENG------STVATAASPAPEEPKAQA--APEKEAAAVAPPERGVGNGR 370
+ AE + E+G + +T + PE P A+A ++EA E + +
Sbjct: 506 LPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQ 565
Query: 371 APDVA----------PEEVDESK----------------------KEDFSEADLVD---- 394
P V E++E + K+ F + L
Sbjct: 566 EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAV 625
Query: 395 VSAYSGLGEDSAGSALE---------------EDDEDDEEDGEPPYEPESGCVEIPGLSE 439
V+ G+ D G + +E++EE+G P E E E +E
Sbjct: 626 VALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEEEEGSPQEEEEEE--EEENRAE 683
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
EE+ + + + + +D+ N + A E EL + R
Sbjct: 684 EEEASTEEED--KEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILR-------- 733
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
+ GLGISI G + GIF+ V+E G A R G ++V D L+EV+G +L G
Sbjct: 734 --QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQG 790
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
A LR V+ + RER E + E + RE
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/71 (43%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 504 EGLGISIIGMG---AGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGV 560
E LGISI G AG GIF+ V+ GAA RDGR++V L+EV+ SL+G+
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 561 TQSFAASVLRN 571
T A +LR+
Sbjct: 1169 THGEAVQLLRS 1179
Score = 39.3 bits (90), Expect = 0.015
Identities = 69/287 (24%), Positives = 103/287 (35%), Gaps = 45/287 (15%)
Query: 224 LHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAPSGDAP---AEKERCPAGQQPPQ 280
LH GP AAG KL + PSG A AE P+GQQPP
Sbjct: 1247 LHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPP- 1305
Query: 281 HRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAAS 340
+P P P V++ E AP + T AAS
Sbjct: 1306 ---SPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQ--------------PPTPGPAAS 1348
Query: 341 PAP----EEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVS 396
P E K + A PP+R V A D+ + +E++K A ++ +
Sbjct: 1349 PEQLSFRERQKYFELEVRVPQAEGPPKR-VSLVGADDLRKMQEEEARKLQQKRAQMLREA 1407
Query: 397 AYSGLGEDSAGSALEED--DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTA 454
A +G A AL+ + E+++ED +PP+ P + + PA + A
Sbjct: 1408 AEAGA---EARLALDGETLGEEEQEDEQPPWAS-------PSPTSRQSPASPPPLG-GGA 1456
Query: 455 PIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEK 501
P++ R + +P A E+ + EL +E EK
Sbjct: 1457 PVRTAKAERRHQERLRVQSPEPPAP------ERALSPAELRALEAEK 1497
Score = 35.4 bits (80), Expect = 0.22
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 12/83 (14%)
Query: 495 FPVE---LEKDSEGLGISIIGMGAGAD-----MGLEKLGIFVKTVTEGGAAHRDGRIQVN 546
+PVE L + LG+SI+G G+D G+++ G+F+ V G A R G ++V
Sbjct: 1000 YPVEEIRLPRAGGPLGLSIVG---GSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVG 1055
Query: 547 DLLVEVDGTSLVGVTQSFAASVL 569
D ++ V+G + T A S L
Sbjct: 1056 DRILAVNGQDVRDATHQEAVSAL 1078
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 59.3 bits (142), Expect = 1e-08
Identities = 69/306 (22%), Positives = 106/306 (34%), Gaps = 65/306 (21%)
Query: 342 APEEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGL 401
AP P+AQ E+E E + EE + S +E+ E +V + G+
Sbjct: 651 APWAPRAQKEEEEEEEGSPQEEE---EEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGV 707
Query: 402 GEDSAGSALEEDDEDDEED--------------------GEPPYEPESGCVEIPGLSEEE 441
D A + L E +EE+ G PY+ + + I +SEE
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE- 766
Query: 442 DPAPSRKIHFSTAPIQV-------------------------FSTYSNEDYDRRNE-DVD 475
PA + ++V + + N +
Sbjct: 767 GPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTIT 826
Query: 476 PMAASAEYELEKRVE---RLELFPVE------------LEKDSEGLGISIIGMGAGADMG 520
P+ +Y +R RL L P E L + GLG SI G
Sbjct: 827 PLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYR 886
Query: 521 LEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMI 580
GIFV + EGGAAHR G +QV D ++ ++G + A S+L + ++
Sbjct: 887 AGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Query: 581 GRERPG 586
RE G
Sbjct: 947 EREAGG 952
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/408 (22%), Positives = 145/408 (35%), Gaps = 82/408 (20%)
Query: 260 APSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIK-PVEVEESGESEAESAPGEV 318
AP GD AE+ + R R P P E++ +K +E S + G
Sbjct: 453 APIGDEDAEEAAA-------EKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSP 505
Query: 319 IQAEVTVHAALENG------STVATAASPAPEEPKAQA--APEKEAAAVAPPERGVGNGR 370
+ AE + E+G + +T + PE P A+A ++EA E + +
Sbjct: 506 LPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQ 565
Query: 371 APDVA----------PEEVDESK----------------------KEDFSEADLVD---- 394
P V E++E + K+ F + L
Sbjct: 566 EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAV 625
Query: 395 VSAYSGLGEDSAGSALE---------------EDDEDDEEDGEPPYEPESGCVEIPGLSE 439
V+ G+ D G + +E++EE+G P E E E +E
Sbjct: 626 VALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEEEEGSPQEEEEEE--EEENRAE 683
Query: 440 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVEL 499
EE+ + + + + +D+ N + A E EL + R
Sbjct: 684 EEEASTEEED--KEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILR-------- 733
Query: 500 EKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVG 559
+ GLGISI G + GIF+ V+E G A R G ++V D L+EV+G +L G
Sbjct: 734 --QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQG 790
Query: 560 VTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQRE 607
A LR V+ + RER E + E + RE
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/71 (43%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 504 EGLGISIIGMG---AGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGV 560
E LGISI G AG GIF+ V+ GAA RDGR++V L+EV+ SL+G+
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 561 TQSFAASVLRN 571
T A +LR+
Sbjct: 1169 THGEAVQLLRS 1179
Score = 39.3 bits (90), Expect = 0.015
Identities = 69/287 (24%), Positives = 103/287 (35%), Gaps = 45/287 (15%)
Query: 224 LHRGPGLPRAAGVPQVNSKLVSKRSRVFQPPPPPPPAPSGDAP---AEKERCPAGQQPPQ 280
LH GP AAG KL + PSG A AE P+GQQPP
Sbjct: 1247 LHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPP- 1305
Query: 281 HRVAPARPPPKPREVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAAS 340
+P P P V++ E AP + T AAS
Sbjct: 1306 ---SPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQ--------------PPTPGPAAS 1348
Query: 341 PAP----EEPKAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVS 396
P E K + A PP+R V A D+ + +E++K A ++ +
Sbjct: 1349 PEQLSFRERQKYFELEVRVPQAEGPPKR-VSLVGADDLRKMQEEEARKLQQKRAQMLREA 1407
Query: 397 AYSGLGEDSAGSALEED--DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTA 454
A +G A AL+ + E+++ED +PP+ P + + PA + A
Sbjct: 1408 AEAGA---EARLALDGETLGEEEQEDEQPPWAS-------PSPTSRQSPASPPPLG-GGA 1456
Query: 455 PIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEK 501
P++ R + +P A E+ + EL +E EK
Sbjct: 1457 PVRTAKAERRHQERLRVQSPEPPAP------ERALSPAELRALEAEK 1497
Score = 35.4 bits (80), Expect = 0.22
Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 12/83 (14%)
Query: 495 FPVE---LEKDSEGLGISIIGMGAGAD-----MGLEKLGIFVKTVTEGGAAHRDGRIQVN 546
+PVE L + LG+SI+G G+D G+++ G+F+ V G A R G ++V
Sbjct: 1000 YPVEEIRLPRAGGPLGLSIVG---GSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVG 1055
Query: 547 DLLVEVDGTSLVGVTQSFAASVL 569
D ++ V+G + T A S L
Sbjct: 1056 DRILAVNGQDVRDATHQEAVSAL 1078
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/104 (34%), Positives = 53/104 (50%), Gaps = 10/104 (9%)
Query: 482 EYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDG 541
EYE E+ + LE+ + GLG SI G +G + GIF+ + GGAA DG
Sbjct: 42 EYEFEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDG 91
Query: 542 RIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
R++VND ++ V+ + V+ S A L+ VR + R RP
Sbjct: 92 RLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 135
Score = 57.0 bits (136), Expect = 7e-08
Identities = 34/86 (39%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
++L K +GLG SI G G G I+V + +GGAA +DGR+QV D L+ V+ S
Sbjct: 143 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGR 582
L VT A ++L+NT V +G+
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKVGK 227
Score = 47.4 bits (111), Expect = 5e-05
Identities = 33/105 (31%), Positives = 50/105 (47%), Gaps = 8/105 (7%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
V L K S GLG +I+G G + GIFV + GG A G +Q D ++ V+G
Sbjct: 319 VVLHKGSTGLGFNIVG-------GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQ 601
L G + AA+ L+ G+ +I + +P + + I EQ
Sbjct: 372 LRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARFEAKIHDLREQ 415
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/104 (34%), Positives = 53/104 (50%), Gaps = 10/104 (9%)
Query: 482 EYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDG 541
EYE E+ + LE+ + GLG SI G +G + GIF+ + GGAA DG
Sbjct: 198 EYEFEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDG 247
Query: 542 RIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
R++VND ++ V+ + V+ S A L+ VR + R RP
Sbjct: 248 RLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 291
Score = 57.0 bits (136), Expect = 7e-08
Identities = 34/86 (39%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
++L K +GLG SI G G G I+V + +GGAA +DGR+QV D L+ V+ S
Sbjct: 299 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 357
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGR 582
L VT A ++L+NT V +G+
Sbjct: 358 LEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/190 (25%), Positives = 74/190 (38%), Gaps = 10/190 (5%)
Query: 414 DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNED 473
D+D EP Y + + P P K +AP + D + +
Sbjct: 442 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS 501
Query: 474 VDPMAASAEYELEKRVERLELFP--VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTV 531
A +R LE P V L K S GLG +I+G G + GIFV +
Sbjct: 502 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG-------GEDGEGIFVSFI 554
Query: 532 TEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
GG A G +Q D ++ V+G L G + AA+ L+ G+ +I + +P + +
Sbjct: 555 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARF 613
Query: 592 AQLIQQTLEQ 601
I EQ
Sbjct: 614 EAKIHDLREQ 623
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/104 (34%), Positives = 53/104 (50%), Gaps = 10/104 (9%)
Query: 482 EYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDG 541
EYE E+ + LE+ + GLG SI G +G + GIF+ + GGAA DG
Sbjct: 93 EYEFEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDG 142
Query: 542 RIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
R++VND ++ V+ + V+ S A L+ VR + R RP
Sbjct: 143 RLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRP 186
Score = 57.0 bits (136), Expect = 7e-08
Identities = 34/86 (39%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
++L K +GLG SI G G G I+V + +GGAA +DGR+QV D L+ V+ S
Sbjct: 194 IKLFKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 252
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGR 582
L VT A ++L+NT V +G+
Sbjct: 253 LEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/190 (25%), Positives = 74/190 (38%), Gaps = 10/190 (5%)
Query: 414 DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNED 473
D+D EP Y + + P P K +AP + D + +
Sbjct: 337 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS 396
Query: 474 VDPMAASAEYELEKRVERLELFP--VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTV 531
A +R LE P V L K S GLG +I+G G + GIFV +
Sbjct: 397 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG-------GEDGEGIFVSFI 449
Query: 532 TEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEV 591
GG A G +Q D ++ V+G L G + AA+ L+ G+ +I + +P + +
Sbjct: 450 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA-GQTVTIIAQYQPEDYARF 508
Query: 592 AQLIQQTLEQ 601
I EQ
Sbjct: 509 EAKIHDLREQ 518
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 57.8 bits (138), Expect = 4e-08
Identities = 69/292 (23%), Positives = 119/292 (40%), Gaps = 30/292 (10%)
Query: 294 EVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPE 353
++++ V + ++ + S P E IQ T + STV + P+ P +
Sbjct: 51 DIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRY 110
Query: 354 KEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEED 413
++ PP+ + +P + EV + SE +L ++ G S S ++
Sbjct: 111 QDEDT--PPQEHI----SPQIT-NEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPT 163
Query: 414 DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNED 473
+ PP P + +P E+ I + P + +T S E N
Sbjct: 164 EAVLPS---PPTVPVIPVLPVPA----ENTVILPTIPQANPPPVLVNTDSLETPTYVN-- 214
Query: 474 VDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTE 533
A+YE E+ + LE+ + GLG SI G +G + IF+ +
Sbjct: 215 ----GTDADYEYEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDSSIFITKIIT 260
Query: 534 GGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
GGAA +DGR++VND ++ V+ + VT S A L+ VR + R +P
Sbjct: 261 GGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Score = 56.6 bits (135), Expect = 9e-08
Identities = 32/90 (35%), Positives = 49/90 (54%), Gaps = 1/90 (1%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++ ++L K +GLG SI G G G I+V + EGGAAH+DG++Q+ D L+ V
Sbjct: 316 KIMEIKLIKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGR 582
+ L VT A + L+NT V + +
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKVAK 404
Score = 47.0 bits (110), Expect = 7e-05
Identities = 31/105 (29%), Positives = 49/105 (46%), Gaps = 8/105 (7%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
V L + S GLG +I+G G + GIF+ + GG A G ++ D ++ V+
Sbjct: 467 VVLHRGSTGLGFNIVG-------GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQ 601
L + AA+ L+N G+ ++ + RP E S I EQ
Sbjct: 520 LRAASHEQAAAALKNA-GQAVTIVAQYRPEEYSRFEAKIHDLREQ 563
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 57.8 bits (138), Expect = 4e-08
Identities = 69/292 (23%), Positives = 119/292 (40%), Gaps = 30/292 (10%)
Query: 294 EVRKIKPVEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPE 353
++++ V + ++ + S P E IQ T + STV + P+ P +
Sbjct: 51 DIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRY 110
Query: 354 KEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEED 413
++ PP+ + +P + EV + SE +L ++ G S S ++
Sbjct: 111 QDEDT--PPQEHI----SPQIT-NEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPT 163
Query: 414 DEDDEEDGEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNED 473
+ PP P + +P E+ I + P + +T S E N
Sbjct: 164 EAVLPS---PPTVPVIPVLPVPA----ENTVILPTIPQANPPPVLVNTDSLETPTYVN-- 214
Query: 474 VDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTE 533
A+YE E+ + LE+ + GLG SI G +G + IF+ +
Sbjct: 215 ----GTDADYEYEE---------ITLERGNSGLGFSIAGGTDNPHIG-DDSSIFITKIIT 260
Query: 534 GGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
GGAA +DGR++VND ++ V+ + VT S A L+ VR + R +P
Sbjct: 261 GGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP 312
Score = 56.6 bits (135), Expect = 9e-08
Identities = 32/90 (35%), Positives = 49/90 (54%), Gaps = 1/90 (1%)
Query: 493 ELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEV 552
++ ++L K +GLG SI G G G I+V + EGGAAH+DG++Q+ D L+ V
Sbjct: 316 KIMEIKLIKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 553 DGTSLVGVTQSFAASVLRNTKGRVRFMIGR 582
+ L VT A + L+NT V + +
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYLKVAK 404
Score = 47.0 bits (110), Expect = 7e-05
Identities = 31/105 (29%), Positives = 49/105 (46%), Gaps = 8/105 (7%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
V L + S GLG +I+G G + GIF+ + GG A G ++ D ++ V+
Sbjct: 467 VVLHRGSTGLGFNIVG-------GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQ 601
L + AA+ L+N G+ ++ + RP E S I EQ
Sbjct: 520 LRAASHEQAAAALKNA-GQAVTIVAQYRPEEYSRFEAKIHDLREQ 563
>gi|148612825 Rap GTPase interactor [Homo sapiens]
Length = 1075
Score = 57.8 bits (138), Expect = 4e-08
Identities = 63/250 (25%), Positives = 98/250 (39%), Gaps = 45/250 (18%)
Query: 342 APEEPKAQAAPEKEAAAVAP----PERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSA 397
AP P A P A VAP P RG +AP S+A +
Sbjct: 846 APSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPP------GRQPSRGGSQAGPPHTDS 899
Query: 398 YSGLGEDSAGSALEEDDEDDEEDGEP-----PYEPESGCVEIPGLSEEEDPAPSRKIHFS 452
L S E D D E G P P +G + G + E D A +
Sbjct: 900 SCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAE---E 956
Query: 453 TAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIG 512
+ P + S ED+ +F VELE+ GLG+ +I
Sbjct: 957 SPPAPSSRSSSTEDF------------------------CYVFTVELERGPSGLGMGLID 992
Query: 513 MGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNT 572
G L G++++T+ G A DGR+ + D ++EV+G+SL+G+ A ++R+
Sbjct: 993 ---GMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHG 1049
Query: 573 KGRVRFMIGR 582
++RF++ +
Sbjct: 1050 GKKMRFLVAK 1059
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 57.4 bits (137), Expect = 5e-08
Identities = 60/229 (26%), Positives = 114/229 (49%), Gaps = 27/229 (11%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDE--ETGEYATDEDEELSPTFP 639
+E+ ++ ++ Q ++ L++E ++ +++ QY E+++ + E E+ E
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 640 GGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEK 699
+ +L + E+ L + EPEK + +E + + E E+QQ + +L E+EK
Sbjct: 956 RERQYRKDKKLQQKEEQL--LGEEPEKRRRQEREKKYRE---EEELQQEEEQLLREEREK 1010
Query: 700 GR---WRVE---KAQLEQSVEE------NKERMEKLEGYWGEAQSLCQAVDEHL---RET 744
R W + K +L+Q E+ K R+++ E + E + L Q ++ L RET
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 745 QAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEE 793
+ + Q LER+Y K + L QQ+E + L++E +RR E R+EE
Sbjct: 1071 RRR-QELERQYRKEEEL----QQEEEQLLREEPEKRRRQERERQCREEE 1114
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/231 (26%), Positives = 106/231 (45%), Gaps = 34/231 (14%)
Query: 581 GRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPG 640
GR+R + + + ++ L E +R+ EQR+ E+ E+ + ++EL F
Sbjct: 780 GRQRLSARPPLREQRERQLRAE--ERQQREQRFLPEEEEKEQRRRQRREREKELQ--FLE 835
Query: 641 GEMAIEVFE----LAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAE------------ 684
E ++ E L E ED L D E + + ++ + + + E
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQE-DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPA 894
Query: 685 IQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRE- 743
+Q+ RK Q L QE E+ +L++ E K R ++ E + E + L Q ++ LRE
Sbjct: 895 LQEQLRKEQQLLQE------EEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 744 -TQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEE 793
+ + Q ER+Y K K+L QQKE + L +E +RR E + R+EE
Sbjct: 948 REKRRRQERERQYRKDKKL----QQKEEQLLGEEPEKRRRQEREKKYREEE 994
Score = 51.6 bits (122), Expect = 3e-06
Identities = 56/216 (25%), Positives = 102/216 (47%), Gaps = 12/216 (5%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDD--EETGEYATDEDEELSPTFPGGEMA 644
E+ ++ Q +Q L +ER +R E R QY +D ++ E E+ E +
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQE-RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 645 IEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQL-----KRKLQSLEQEK 699
E EL + E+ L + E + ++ + K + + E Q L KR+LQ E++
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 700 GRWRVEKAQLEQSVEENKE--RMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSK 757
+ + EQ + E +E R ++LE + + + L Q ++ LRE + + ER+ +
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE--R 1108
Query: 758 AKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEE 793
R ++ QQ+E + L++E +RR E R+EE
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Score = 50.8 bits (120), Expect = 5e-06
Identities = 53/228 (23%), Positives = 106/228 (46%), Gaps = 15/228 (6%)
Query: 569 LRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDE--ETGEY 626
L++ KG E + E+ +L ++ E+++ QR + R Q E+ E +
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 627 ATDEDEELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQ 686
E+E+L P + EL E E+ L ++ + + + +E Q + E Q
Sbjct: 253 LRKEEEKLQEEEPQRQR-----ELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE---Q 304
Query: 687 QLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQA 746
QL+RK + +E+ R E+ + + EE +E+ + E Q L + +E RE Q
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL 364
Query: 747 QYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEM 794
+ + E + + ++L ++ Q + + L++E RR E +L R++++
Sbjct: 365 RREQEEER--REQQLRREQQLRREQQLRREQQLRR---EQQLRREQQL 407
Score = 47.0 bits (110), Expect = 7e-05
Identities = 49/230 (21%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
R+R E+ Q + E+E+ +RE ++ + + EE + +E+
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
+ E L E E+ + ++ KF+E +++H + + +++L+ E+E+ +
Sbjct: 1337 KFREEEQLLQEREEQ----PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER-K 1391
Query: 702 WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLC-QAVDEHLRETQAQY--QALERKYSKA 758
+ E+ QL E + R ++ + E Q L Q D RE + Q Q ERK+ +
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 759 KRLIKD------------YQQKEIEFLKKETAQRRVLEESELARKEEMDK 796
++ ++ Q++E + L ++ R+ LEE + R++E D+
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/234 (25%), Positives = 104/234 (44%), Gaps = 37/234 (15%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIE 646
E+ E+ Q +Q L +ER +R E QY E++E E+E+L P E
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELE-RQYREEEE-----VQQEEEQLLREEPEKRRRQE 1165
Query: 647 VFELAENEDALSPVDMEPEKLV----HKFKELQIKHAVTEAEIQQLKRKLQSLEQE---- 698
+ E+ L E E+L+ K ++ + + E E+Q+ KRK + +++
Sbjct: 1166 LERQYREEEEL---QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Query: 699 -KGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSK 757
K +W EK E +V +NK + E + Q D LR+ Q+Q
Sbjct: 1223 LKWQWEPEK---ENAVRDNKVYCKGREN-----EQFRQLEDSQLRDRQSQ--------QD 1266
Query: 758 AKRLIKDYQQKEIEFLKKETAQ--RRVLEESELARKEEMD-KLLDKISELEGNL 808
+ L+ + Q+++ E ++ Q R EE +L R+E+ + K D+ S+ E L
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Score = 45.4 bits (106), Expect = 2e-04
Identities = 55/235 (23%), Positives = 110/235 (46%), Gaps = 32/235 (13%)
Query: 581 GRERPGEQSEVAQLIQQTLEQERW-QREMMEQRYAQYGEDDE-------ETGEYATDED- 631
G E+ +Q + Q +Q ++E W QR+ ++R + E+++ ET E+ +E
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 632 ---EELSPTFPGGEMAIEVFELAENEDALSPVDMEPE------KLVHKFKELQIKHAVTE 682
E L G E + + E +D + + E E L + ++LQ + +
Sbjct: 211 RRRELLELRRKGREEKQQ--QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 683 AEIQQLKRKLQSLE-QEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHL 741
E+Q+ + +L+ LE QE R R E+ Q +Q + ++ K E E Q E
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ-------EER 321
Query: 742 RETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDK 796
RE Q + + E + + ++L ++ +++ + L++E + R E +L R++E ++
Sbjct: 322 REQQERREQQEER--REQQLRREQEERREQQLRREQEEER--REQQLRREQEEER 372
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/228 (20%), Positives = 107/228 (46%), Gaps = 10/228 (4%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
RE+ + + + QQ +++ +RE E+R+ Q + ++E E ++E +
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQ--KHEQERREQRLKREQEERRDWLKR 460
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFK-ELQIKHAVTEAEIQQLKRKLQSLEQEKG 700
E E E + L D E E+ K E + + E QQL+R+ + +++
Sbjct: 461 EEETERHEQERRKQQLKR-DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 701 RWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAK- 759
+ + E+ +L+Q + ++ + E + L + +E E + + Q L+R+ + +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQE---ERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 760 RLIKDYQQKEIEFLKKETAQR--RVLEESELARKEEMDKLLDKISELE 805
+L+K +++ + LK+E +R + L+ E+ R E+ ++ ++ E
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Score = 43.9 bits (102), Expect = 6e-04
Identities = 58/240 (24%), Positives = 112/240 (46%), Gaps = 34/240 (14%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDE----ETGEYATDEDEELSPTF---P 639
E+ E+ Q +Q L +E+ +R ++R QY E++E + + DED+ + P
Sbjct: 1172 EEEELQQEEEQLLREEQEKRR--QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEP 1229
Query: 640 GGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQL--KRKLQSLEQ 697
E A+ ++ + E E+ + ++ Q++ ++ ++Q L +++ + EQ
Sbjct: 1230 EKENAVR-------DNKVYCKGRENEQF-RQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Query: 698 EKGRWRV------EKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLR--ETQAQYQ 749
E+ RW+ E+ QLE+ EE KE + E Q L + +E R ET +++
Sbjct: 1282 ERRRWQQRDRHFPEEEQLER--EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339
Query: 750 A-----LERKYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISEL 804
ER+ +R +D + +E E +E ++ + EE L R+E K L + +L
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Score = 43.9 bits (102), Expect = 6e-04
Identities = 44/210 (20%), Positives = 92/210 (43%), Gaps = 7/210 (3%)
Query: 596 QQTLEQERWQREMMEQRYAQYGEDDE----ETGEYATDEDEELSPTFPGGEMAIEVFELA 651
+Q L QER ++ E++ Q E+ + E +E+++L + +
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Query: 652 ENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSL---EQEKGRWRVEKAQ 708
E E + + + + K LQ + + E Q +R+ + E+E+ R E+ Q
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Query: 709 LEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQK 768
L + + K R+E+ + E + ++ LR + Q Q + + K + + Q++
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 769 EIEFLKKETAQRRVLEESELARKEEMDKLL 798
E + L ++ R+ LEE R++E ++ L
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Score = 43.5 bits (101), Expect = 8e-04
Identities = 47/216 (21%), Positives = 101/216 (46%), Gaps = 22/216 (10%)
Query: 596 QQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENED 655
+++L Q+R Q E + + + +EE G+ + +E GE E E E D
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 656 ALSPVDMEPEKLVHKFKELQIKHAVTE-------------AEIQQLKRKLQSLEQEKGRW 702
D E + +++E + + A E + +QL+R+ + KGR
Sbjct: 166 R-QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR- 223
Query: 703 RVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLI 762
E+ Q ++ +++ E+ E W + +++ + +E L+E + Q Q R+ + + +
Sbjct: 224 --EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ---RELQEEEEQL 278
Query: 763 KDYQQKEI--EFLKKETAQRRVLEESELARKEEMDK 796
+ +++E+ E ++E Q+R+ E +L RK+E ++
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Score = 43.1 bits (100), Expect = 0.001
Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 48/219 (21%)
Query: 584 RPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEM 643
R EQ +Q L ++ Q+++ ++R ++ ED++ E E+++L +
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER---EEQQLHRQERDRKF 1645
Query: 644 AIEVFELAENEDALSPVDMEPEKLVH----KFKELQIKHAVTEAEIQQLKRKLQSLEQEK 699
E +L E ++L H KF+E + + E E QQL+R QE+
Sbjct: 1646 LEEEPQLRRQE--------REQQLRHDRDRKFREEE--QLLQEGEEQQLRR------QER 1689
Query: 700 GR-WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKA 758
R +R E+ QL + E K E E Q + Q LERK+ +
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQE---------------------EQQLRRQELERKFREE 1728
Query: 759 KRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKL 797
++L Q+ E E L+++ R++LEE +L + E +L
Sbjct: 1729 EQL---RQETEQEQLRRQERYRKILEEEQLRPEREEQQL 1764
Score = 42.7 bits (99), Expect = 0.001
Identities = 59/239 (24%), Positives = 109/239 (45%), Gaps = 27/239 (11%)
Query: 584 RPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYAT-------DEDEELSP 636
R E+ Q +Q ++R +RE E+R E++ E E D++EE
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 637 TFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSL- 695
+ + +E E E ++ + + + + +E ++K E +QQ R Q L
Sbjct: 487 RW----LKLEEEERREQQERR---EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 696 -EQEKGRWRVEKAQLEQSVE-ENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALER 753
EQE+ R ++ K + E+ +E E +E+ K E Q L RE + + Q L+R
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL-------KREEERRQQRLKR 592
Query: 754 KYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQTLR 812
+ + +RL + +++E+E L++E + + L+ E +E +LL + E Q LR
Sbjct: 593 E--QEERLEQRLKREEVERLEQEERREQRLKREE-PEEERRQQLLKSEEQEERRQQQLR 648
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/211 (22%), Positives = 105/211 (49%), Gaps = 25/211 (11%)
Query: 600 EQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSP 659
E+++ +R+ +E+++ + + +ET E E+L E + E+ L P
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQET------EQEQLRRQ--------ERYRKILEEEQLRP 1757
Query: 660 VDMEPEKLVHKFKELQIKHAVTEAEIQQLK--RKLQSLEQEKGRWRVEKAQLEQSVEENK 717
+ E ++L + ++ + + E +++Q + ++L+S QE R E+ QL Q EE +
Sbjct: 1758 -EREEQQLRRQERDRKFRE---EEQLRQEREEQQLRS--QESDRKFREEEQLRQEREEQQ 1811
Query: 718 ERMEKLEG--YWGEAQSLCQAVDEHLR-ETQAQYQALERKYSKAKRLIKDYQQKEIEFLK 774
R ++ +G W E Q + ++ LR E QY+A E+ ++ K ++ + + E K
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 775 KETAQRRVLEESELARKEEMDKLLDKISELE 805
+ + R L E + R+++ ++ ++ E++
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQVGEIK 1902
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 38/213 (17%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
RE+ ++ E + +QQ L E+ R E+R Q + +EE ++ L
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR----- 569
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKR-KLQSLEQEKG 700
E E D L + E E+ ++ ++K E Q+LKR +++ LEQE+
Sbjct: 570 -------EQEERRDQL--LKREEER-----RQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 701 RWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKR 760
R ++ + E+ EE ++++ K E E R+ Q + + ER+ + KR
Sbjct: 616 --REQRLKREEPEEERRQQLLKSE------------EQEERRQQQLRREQQERREQRLKR 661
Query: 761 LIKDYQQKEIEFLKKETAQRRVLEESELARKEE 793
++ +++ + LK+E + R E ELA +E+
Sbjct: 662 --EEEEERLEQRLKREHEEER--REQELAEEEQ 690
Score = 37.0 bits (84), Expect = 0.074
Identities = 55/267 (20%), Positives = 110/267 (41%), Gaps = 54/267 (20%)
Query: 590 EVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEEL-----SPTFPGGEMA 644
E QL+Q+ E++ +R+ ++++ + +E G +E++ L F E
Sbjct: 1340 EEEQLLQER-EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 645 IEVFELAEN--EDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKL----QSLEQE 698
+ E + +D E ++L + ++ + + + Q+ +RK Q L QE
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 699 KGR-WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLC-QAVDEHLRETQAQYQALERKYS 756
+ R +R E+ L++ E+ R E+ + E Q L Q D RE + + Q ERK+
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 757 KAKRLIKDYQQKEIEFLKKETAQRRV---------------------------------- 782
+ ++ + QQ++ +FL++E RR
Sbjct: 1519 EEEQQLHR-QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 783 -----LEESELARKEEMDKLLDKISEL 804
LEE ++ R+E+ K ++ +L
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Score = 36.6 bits (83), Expect = 0.097
Identities = 46/210 (21%), Positives = 89/210 (42%), Gaps = 23/210 (10%)
Query: 587 EQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIE 646
EQ E + Q EQE +RE +R Q + + E +++L E +
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-----EQQLR 408
Query: 647 VFELAENEDAL---SPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWR 703
+ E L + E E+ H+ K Q E Q+LKR+ ++E+ W
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQ------ERREQRLKRE----QEERRDWL 458
Query: 704 VEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIK 763
+ + E+ +E +++ K + + + +E RE Q + + R+ + +R +
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 764 DYQQKEIEFLKKETAQRRVLEESELARKEE 793
+Q+E +E Q+R+ E +L R++E
Sbjct: 519 LKRQEE-----EERLQQRLRSEQQLRREQE 543
Score = 31.6 bits (70), Expect = 3.1
Identities = 44/187 (23%), Positives = 73/187 (39%), Gaps = 41/187 (21%)
Query: 627 ATDEDEELSPTFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQ 686
AT DEE G E ++ E++ P D + E E
Sbjct: 92 ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLE------------------EEP 133
Query: 687 QLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQA 746
+R+ + EQE+ +L + EE E+ E+LE Q Q DE L +
Sbjct: 134 GQRRRQKRQEQER--------ELAEG-EEQSEKQERLE------QRDRQRRDEELWRQRQ 178
Query: 747 QYQALERKYSKAKRLIKDYQQKEIEFLKKETAQRRVL--------EESELARKEEMDKLL 798
++Q E + ++ ++L + EF +E +RR L EE + R+E D++
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 799 DKISELE 805
+ E E
Sbjct: 239 QEEEEKE 245
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 56.6 bits (135), Expect = 9e-08
Identities = 45/221 (20%), Positives = 102/221 (46%), Gaps = 14/221 (6%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQRE-----MMEQRYAQYGEDDEETGEYATDEDEELSP 636
+E+ EQ E Q ++ EQE+ Q + E++ + E E E +++E++
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKM-- 413
Query: 637 TFPGGEMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLE 696
GE +++E E+ + + + + K +E + K E +I++ + +Q E
Sbjct: 414 ----GEQEEKMWE---QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466
Query: 697 QEKGRWRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYS 756
++ G + + E ++E +E+M + E E + + +E +RE + Q E K
Sbjct: 467 EKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW 526
Query: 757 KAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKL 797
+ + + + ++K E +K Q + E E+ +++ +K+
Sbjct: 527 EQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/219 (20%), Positives = 99/219 (45%), Gaps = 2/219 (0%)
Query: 582 RERPGEQSEVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGG 641
+ER + E + I++ E+ R Q EMM ++ + +E E ++ EL
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE-KEEKIRELEEKMHEQ 356
Query: 642 EMAIEVFELAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
E E E + E+ + + E+ +++ + K E +I++ + +Q E++ G
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-KIREQEEKIREQEEMMQEQEEKMGE 415
Query: 702 WRVEKAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRL 761
+ + E+ ++E +E+M + E E + + +E +RE + Q E K + +
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Query: 762 IKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDK 800
+ + + K E +K Q + E E +E+ +K+ ++
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 514
Score = 50.8 bits (120), Expect = 5e-06
Identities = 56/283 (19%), Positives = 124/283 (43%), Gaps = 15/283 (5%)
Query: 536 AAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGR-----ERPGE-QS 589
A R+ QV + + + + + ++ ++ +G R +I R + GE +
Sbjct: 108 ALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQ 167
Query: 590 EVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFE 649
++ + Q + +R+ E+ ++R A E T DEEL + +++ E
Sbjct: 168 ALSAVATQKKKADRYIEELTKERDALSLELYRNT-----ITDEELKEKNAKLQEKLQLVE 222
Query: 650 LAENEDALSPVDM----EPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVE 705
++E L+ ++ E KL+ ++LQ + E+Q + KLQ+ +E W
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 282
Query: 706 KAQLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDY 765
Q E+ + +E++++ E E + + +E +R + E K + + ++ +
Sbjct: 283 NQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 342
Query: 766 QQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNL 808
++K E +K Q ++ E+ E ++EE + +K E E +
Sbjct: 343 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 385
Score = 48.1 bits (113), Expect = 3e-05
Identities = 50/236 (21%), Positives = 108/236 (45%), Gaps = 17/236 (7%)
Query: 587 EQSEVAQLIQQTLEQERW-QREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAI 645
E++E+ + Q E++ W Q E +++R + E +E+ E + + E
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMR 333
Query: 646 EVFELA-ENEDALSPVDM---EPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGR 701
E+ E E+ + ++ E EK+ + ++ Q + + E E +Q + ++EK R
Sbjct: 334 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 393
Query: 702 WRVEKA--------QLEQSVEENKERMEKLEGYWGEAQSLCQAVDEHLRETQAQYQALER 753
+ EK + E+ + E +E+M + E E + + +E +RE + + + E
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 754 KYSKAKRLIKDYQQKEIEFLKKETAQRRVLEESELARKEEMDKLLDKISELEGNLQ 809
K + + ++++ ++K E K Q ++E E E+M + +KI E E ++
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE----EKMRRQEEKIREQEKKIR 505
Score = 30.4 bits (67), Expect = 6.9
Identities = 25/133 (18%), Positives = 61/133 (45%), Gaps = 6/133 (4%)
Query: 590 EVAQLIQQTLEQERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFE 649
E + I++ E+ R Q EMM+++ + GE + + E E+ +M + +
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEE------KMRRQEEK 496
Query: 650 LAENEDALSPVDMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQL 709
+ E E + + + + +E + K E ++ + + K+Q E++ R + +
Sbjct: 497 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556
Query: 710 EQSVEENKERMEK 722
E + + +E+M++
Sbjct: 557 EVRLRQQEEKMQE 569
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/187 (24%), Positives = 81/187 (43%), Gaps = 19/187 (10%)
Query: 483 YELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGR 542
Y + ++ ++ ++L K +GLG SI G G G I+V + EGGAAH+DGR
Sbjct: 190 YVMRRKPPAEKVMEIKLIKGPKGLGFSIAG-GVGNQHIPGDNSIYVTKIIEGGAAHKDGR 248
Query: 543 IQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQE 602
+Q+ D ++ V+ L V A + L+NT V + + S +
Sbjct: 249 LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLS------------D 296
Query: 603 RWQREMMEQRYAQYGEDDEETGEY-ATDEDEELSPTFPGGEMAIEVFELAENEDALSPVD 661
+ + Y+Q+ +++ Y TD ++PT P + L E + +
Sbjct: 297 SYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEED-----IP 351
Query: 662 MEPEKLV 668
EP ++V
Sbjct: 352 REPRRIV 358
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 478 AASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAA 537
A E ++ +E + LE+ + GLG SI G +G + IF+ + GGAA
Sbjct: 90 APGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIG-DDPSIFITKIIPGGAA 148
Query: 538 HRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERP 585
+DGR++VND ++ V+ + VT S A L+ VR + R +P
Sbjct: 149 AQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP 196
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/105 (28%), Positives = 49/105 (46%), Gaps = 8/105 (7%)
Query: 497 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 556
+ + + S GLG +I+G G + GIF+ + GG A G ++ D ++ V+G
Sbjct: 357 IVIHRGSTGLGFNIVG-------GEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVD 409
Query: 557 LVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLEQ 601
L + AA L+N G+ +I + +P E S I EQ
Sbjct: 410 LRNASHEQAAIALKNA-GQTVTIIAQYKPEEYSRFEAKIHDLREQ 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,614,343
Number of Sequences: 37866
Number of extensions: 2336104
Number of successful extensions: 37519
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 614
Number of HSP's successfully gapped in prelim test: 1985
Number of HSP's that attempted gapping in prelim test: 19203
Number of HSP's gapped (non-prelim): 14003
length of query: 817
length of database: 18,247,518
effective HSP length: 111
effective length of query: 706
effective length of database: 14,044,392
effective search space: 9915340752
effective search space used: 9915340752
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.