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Search of human proteins with 140561024
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
(907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 1792 0.0
gi|140561027 CASK-interacting protein CIP98 isoform 2 [Homo sapi... 1041 0.0
gi|13376349 PDZ domain containing 7 [Homo sapiens] 167 5e-41
gi|41281808 harmonin isoform b3 [Homo sapiens] 141 3e-33
gi|71480164 harmonin isoform a [Homo sapiens] 141 3e-33
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 84 8e-16
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 84 8e-16
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 83 1e-15
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 83 1e-15
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 81 5e-15
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 79 2e-14
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 78 3e-14
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 77 9e-14
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 77 9e-14
gi|45827729 scribble isoform b [Homo sapiens] 75 2e-13
gi|45827731 scribble isoform a [Homo sapiens] 75 2e-13
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 72 2e-12
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 72 2e-12
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 70 1e-11
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 70 1e-11
gi|148746189 multiple PDZ domain protein [Homo sapiens] 69 3e-11
gi|112382257 InaD-like [Homo sapiens] 65 2e-10
gi|9966877 golgi associated PDZ and coiled-coil motif containing... 65 4e-10
gi|62868213 golgi associated PDZ and coiled-coil motif containin... 65 4e-10
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 64 5e-10
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 64 5e-10
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 64 5e-10
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 64 5e-10
gi|7706025 PDZ domain containing 11 [Homo sapiens] 64 8e-10
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 63 1e-09
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 1792 bits (4642), Expect = 0.0
Identities = 907/907 (100%), Positives = 907/907 (100%)
Query: 1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 60
MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH
Sbjct: 1 MNAPLDGLSVSSSSTGSLGSAAGAGGGGGAGLRLLSANVRQLHQALTALLSEAEREQFTH 60
Query: 61 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 120
CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT
Sbjct: 61 CLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATT 120
Query: 121 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 180
PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE
Sbjct: 121 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 180
Query: 181 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 240
GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ
Sbjct: 181 GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQ 240
Query: 241 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 300
GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY
Sbjct: 241 GRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEY 300
Query: 301 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 360
GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG
Sbjct: 301 GLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 360
Query: 361 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 420
RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN
Sbjct: 361 RLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGN 420
Query: 421 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 480
QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR
Sbjct: 421 QTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVR 480
Query: 481 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 540
GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS
Sbjct: 481 GTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSS 540
Query: 541 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR 600
ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR
Sbjct: 541 ARNTLDLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPR 600
Query: 601 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS 660
KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS
Sbjct: 601 KLGREDLQPPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPS 660
Query: 661 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH 720
SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH
Sbjct: 661 SKRPLDAHLALVNQHPIGPFPRVQSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQH 720
Query: 721 FVMVEVHRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGR 780
FVMVEVHRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGR
Sbjct: 721 FVMVEVHRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGR 780
Query: 781 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL 840
QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL
Sbjct: 781 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL 840
Query: 841 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 900
PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV
Sbjct: 841 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 900
Query: 901 TEFNVML 907
TEFNVML
Sbjct: 901 TEFNVML 907
>gi|140561027 CASK-interacting protein CIP98 isoform 2 [Homo
sapiens]
Length = 524
Score = 1041 bits (2692), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 384 MANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMA 443
MANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMA
Sbjct: 1 MANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMA 60
Query: 444 YYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESM 503
YYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESM
Sbjct: 61 YYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESM 120
Query: 504 KARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEETGEAVQGNINALPD 563
KARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEETGEAVQGNINALPD
Sbjct: 121 KARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEETGEAVQGNINALPD 180
Query: 564 VSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSA 623
VSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSA
Sbjct: 181 VSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGREDLQPPSSMPSCSGTVFSA 240
Query: 624 PQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRPLDAHLALVNQHPIGPFPRV 683
PQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRPLDAHLALVNQHPIGPFPRV
Sbjct: 241 PQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRPLDAHLALVNQHPIGPFPRV 300
Query: 684 QSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQ 743
QSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQ
Sbjct: 301 QSPPHLKSPSAEATVAGGCLLPPSPSGHPDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQ 360
Query: 744 TRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGA 803
TRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGA
Sbjct: 361 TRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGA 420
Query: 804 NKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHV 863
NKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHV
Sbjct: 421 NKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHV 480
Query: 864 ILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML 907
ILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML
Sbjct: 481 ILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLVTEFNVML 524
Score = 35.0 bits (79), Expect = 0.32
Identities = 24/60 (40%), Positives = 31/60 (51%), Gaps = 2/60 (3%)
Query: 289 SLGLTIRGGAEYGLGI-YITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLL 346
+LG+ I GGA + I + G A G LKVG ILEVNG + H EA R++
Sbjct: 442 TLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARII 501
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 167 bits (422), Expect = 5e-41
Identities = 102/235 (43%), Positives = 134/235 (57%), Gaps = 14/235 (5%)
Query: 142 SLRRAKAHEG-LGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVT 200
S+R K+ G LGFS+RGGSEHG+GI+VS VE GS AE+ GL VGD+I VN SL T
Sbjct: 86 SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITEVNGLSLESTT 145
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
AVK L S +L + V GR+PG + TWVD R + P +
Sbjct: 146 MGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTS--S 203
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGL 320
++G RR +HL D+ LG IRGG E+GLGIY++ VD G AE +G+
Sbjct: 204 EDGVRR-IVHLYTTSDDF----------CLGFNIRGGKEFGLGIYVSKVDHGGLAEENGI 252
Query: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWI 375
KVGDQ+L NG F +I H +AV +LK H++LT+K+ GR P + V E W+
Sbjct: 253 KVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWL 307
Score = 84.7 bits (208), Expect = 3e-16
Identities = 44/107 (41%), Positives = 63/107 (58%)
Query: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRV 191
S+ G R+V L LGF+IRGG E G+GIYVS V+ G LAE+ G++VGDQ+L
Sbjct: 202 SSEDGVRRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAA 261
Query: 192 NDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVD 238
N ++H++AV+ LKG ++L++ GR P Y W+D
Sbjct: 262 NGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLD 308
Score = 35.4 bits (80), Expect = 0.24
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 3/72 (4%)
Query: 817 VRVKKS-AATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGK 875
VRV+KS A LG ++ GG+ + + ++ G SA G L VG I EVNGL+L
Sbjct: 87 VRVEKSPAGRLGFSVRGGSEHGLGI-FVSKVEEGSSAERAG-LCVGDKITEVNGLSLEST 144
Query: 876 EHREAARIIAEA 887
A +++ +
Sbjct: 145 TMGSAVKVLTSS 156
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 141 bits (355), Expect = 3e-33
Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 40/316 (12%)
Query: 43 HQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSD 102
H+ + ++AE++ L YH +V LV L+++++ P + L +R +IP
Sbjct: 11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKH 70
Query: 103 QLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH 162
Q+ +DQ T P R S EVRL L EGLG S+RGG E
Sbjct: 71 QVEYDQLT----------PRR--------SRKLKEVRLDRLHP----EGLGLSVRGGLEF 108
Query: 163 GVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAG 222
G G+++S + G A+ GL+VGD+I+R+N S++ TH E + ++ K + + V G
Sbjct: 109 GCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIG 168
Query: 223 RIPGGYVTNHIYTW--VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKV 280
IP + TW VD + +S G+ G G+R + EKKV
Sbjct: 169 LIPVKSSPDEPLTWQYVD---QFVSESGGVRGSLGSP-----GNRENK--------EKKV 212
Query: 281 NLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHD 340
+ L R LG +I G GI+I+ V PGS + GL++GDQI+EVNG F N+ H
Sbjct: 213 FISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHK 272
Query: 341 EAVRLLKSSRHLILTV 356
EAV +LKSSR L +++
Sbjct: 273 EAVNVLKSSRSLTISI 288
Score = 73.2 bits (178), Expect = 1e-12
Identities = 36/121 (29%), Positives = 69/121 (57%), Gaps = 3/121 (2%)
Query: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
K+V L LGL++RGG E+G G++I+ + G +A+ GL+VGD+I+ +NG S +
Sbjct: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSC 145
Query: 338 LHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTE 397
H+E + L+++ + + + V+ +G +P + + W + + ++ S G G L +
Sbjct: 146 THEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW---QYVDQFVSESGGVRGSLGSP 202
Query: 398 G 398
G
Sbjct: 203 G 203
Score = 64.7 bits (156), Expect = 4e-10
Identities = 32/71 (45%), Positives = 45/71 (63%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKG 210
GLG SI G GI++S V+PGSL+ + GL +GDQI+ VN + + H EAV LK
Sbjct: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
Query: 211 SKKLVLSVYSA 221
S+ L +S+ +A
Sbjct: 281 SRSLTISIVAA 291
Score = 36.6 bits (83), Expect = 0.11
Identities = 86/385 (22%), Positives = 144/385 (37%), Gaps = 56/385 (14%)
Query: 546 DLEETGEAVQGNINALPDVSVDDVRSTSQGLSSFKPLPRPPPLAQGNDLPLGQPRKLGRE 605
DLEE+ E +Q + L ++ + S +S P PPP + PL P +
Sbjct: 479 DLEES-EKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVS---PLAPPLRRFAG 534
Query: 606 DLQ-PPSSMPSCSGTVFSAPQNRSPPAGTAPTPGTSSAQDLPSSPIYASVSPANPSSKRP 664
L + + +F P P T SA P+ P+NP K P
Sbjct: 535 GLHLHTTDLDDIPLDMFYYP------------PKTPSAL-----PVMPHPPPSNPPHKVP 577
Query: 665 LDAHLALVNQHPIGPFPRVQ-SPPHLKSPSAEATVAGGCLLPPSP---------SGHPDQ 714
L L P VQ +PP + P + V L P P S HP +
Sbjct: 578 APPVLPLSGHVSASSSPWVQRTPPPIPIPPPPS-VPTQDLTPTRPLPSALEEALSNHPFR 636
Query: 715 TG-TNQHFVMVEVHRPDSEPDVNEVRAL------------PQTRTASTLSHLSDSGQTLS 761
TG T E +P + V PQ +S +S
Sbjct: 637 TGDTGNPVEDWEAKNHSGKPTNSPVPEQSFPPTPKTFCPSPQPPRGPGVSTISKPVMVHQ 696
Query: 762 EDSGV--DAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANK--PPGLLEPTSTLV 817
E + + A ++E ++ V ++ ++ + E D + P ++ L+
Sbjct: 697 EPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFRKYEEGFDPYSMFTPEQIMGKDVRLL 756
Query: 818 RVKKSAATLGIAIEGGANTRQPLPRIV--TIQRGGSAHNCGQLKVGHVILEVNGLTLRGK 875
R+KK + L +A+EGG ++ P+ ++V + G+A G + G I+ +NG +
Sbjct: 757 RIKKEGS-LDLALEGGVDS--PIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDY 813
Query: 876 EHREAARIIAEAFKTKDRDYIDFLV 900
EA + +A+ + D+ID +V
Sbjct: 814 TLAEAEAALQKAW-NQGGDWIDLVV 837
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 141 VSLRRAKAHEGLGFSIRGGSEHGVG-IYVSLVEPGSLAEKEGLRV-GDQILRVNDKSLAR 198
V L R K L ++ GG + +G + VS V AE+ G V GD+I+ +N K +
Sbjct: 753 VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 812
Query: 199 VTHAEAVKALK 209
T AEA AL+
Sbjct: 813 YTLAEAEAALQ 823
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 141 bits (355), Expect = 3e-33
Identities = 106/316 (33%), Positives = 159/316 (50%), Gaps = 40/316 (12%)
Query: 43 HQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSD 102
H+ + ++AE++ L YH +V LV L+++++ P + L +R +IP
Sbjct: 11 HKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKH 70
Query: 103 QLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH 162
Q+ +DQ T P R S EVRL L EGLG S+RGG E
Sbjct: 71 QVEYDQLT----------PRR--------SRKLKEVRLDRLHP----EGLGLSVRGGLEF 108
Query: 163 GVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAG 222
G G+++S + G A+ GL+VGD+I+R+N S++ TH E + ++ K + + V G
Sbjct: 109 GCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIG 168
Query: 223 RIPGGYVTNHIYTW--VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKV 280
IP + TW VD + +S G+ G G+R + EKKV
Sbjct: 169 LIPVKSSPDEPLTWQYVD---QFVSESGGVRGSLGSP-----GNRENK--------EKKV 212
Query: 281 NLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHD 340
+ L R LG +I G GI+I+ V PGS + GL++GDQI+EVNG F N+ H
Sbjct: 213 FISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHK 272
Query: 341 EAVRLLKSSRHLILTV 356
EAV +LKSSR L +++
Sbjct: 273 EAVNVLKSSRSLTISI 288
Score = 73.2 bits (178), Expect = 1e-12
Identities = 36/121 (29%), Positives = 69/121 (57%), Gaps = 3/121 (2%)
Query: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
K+V L LGL++RGG E+G G++I+ + G +A+ GL+VGD+I+ +NG S +
Sbjct: 86 KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSC 145
Query: 338 LHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTE 397
H+E + L+++ + + + V+ +G +P + + W + + ++ S G G L +
Sbjct: 146 THEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTW---QYVDQFVSESGGVRGSLGSP 202
Query: 398 G 398
G
Sbjct: 203 G 203
Score = 64.7 bits (156), Expect = 4e-10
Identities = 32/71 (45%), Positives = 45/71 (63%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKG 210
GLG SI G GI++S V+PGSL+ + GL +GDQI+ VN + + H EAV LK
Sbjct: 221 GLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
Query: 211 SKKLVLSVYSA 221
S+ L +S+ +A
Sbjct: 281 SRSLTISIVAA 291
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 141 VSLRRAKAHEGLGFSIRGGSEHGVG-IYVSLVEPGSLAEKEGLRV-GDQILRVNDKSLAR 198
V L R K L ++ GG + +G + VS V AE+ G V GD+I+ +N K +
Sbjct: 453 VRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTD 512
Query: 199 VTHAEAVKALK 209
T AEA AL+
Sbjct: 513 YTLAEAEAALQ 523
Score = 34.3 bits (77), Expect = 0.54
Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIV--TIQRGGSAHNCGQLKVGHV 863
P ++ L+R+KK + L +A+EGG ++ P+ ++V + G+A G + G
Sbjct: 445 PEQIMGKDVRLLRIKKEGS-LDLALEGGVDS--PIGKVVVSAVYERGAAERHGGIVKGDE 501
Query: 864 ILEVNGLTLRGKEHREAARIIAEAFKTKDRDYIDFLV 900
I+ +NG + EA + +A+ + D+ID +V
Sbjct: 502 IMAINGKIVTDYTLAEAEAALQKAW-NQGGDWIDLVV 537
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 83.6 bits (205), Expect = 8e-16
Identities = 90/287 (31%), Positives = 136/287 (47%), Gaps = 23/287 (8%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQI 188
P +++ ++ K +GLGFSI GG ++H G IYV+ + G A K+G L++GD+I
Sbjct: 196 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 189 LRVNDKSLARVTHAEAVKALKGSKKLV---LSVYSAGRIPGGYVTNHIYT-WVDPQGRSI 244
L VN L V H +AV ALK + +V ++ S + Y I T + I
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEI 315
Query: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDE----KKVNLVLGDGRS-LGLTIRGGAE 299
S S L + A+ R S + G+E + +V+ G + LG I GG E
Sbjct: 316 SHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG-E 374
Query: 300 YGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKD 358
G GI+I+ + G A+ SG L+ GDQIL VNG N H++A LK++ + +
Sbjct: 375 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Query: 359 VGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFY 405
++R E K +RE + NS+ G + K GFY
Sbjct: 435 YKPEEYSRF---EAK---IHDLREQLMNSSLGSGTASLRSNPKRGFY 475
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/225 (27%), Positives = 98/225 (43%), Gaps = 51/225 (22%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQIL 189
GE+ + + + GLGFSI GG+++ I+++ + PG A ++G LRV D IL
Sbjct: 102 GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 161
Query: 190 RVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSG 249
VN+ + VTH+ AV+ALK + +V +Y R P I P+G S G
Sbjct: 162 FVNEVDVREVTHSAAVEALKEAGSIV-RLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGG 220
Query: 250 LPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGV 309
+ H + GD IY+T +
Sbjct: 221 VGNQH----------------------------IPGDN---------------SIYVTKI 237
Query: 310 DPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
G A G L++GD+IL VN +++H++AV LK++ ++
Sbjct: 238 IEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
Score = 37.7 bits (86), Expect = 0.049
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLT 871
+++ K LG +I GG Q +P + I GG+AH G+L++G IL VN +
Sbjct: 204 IKLIKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 262
Query: 872 LRGKEHREAARIIAEAF 888
L H +A + +
Sbjct: 263 LEDVMHEDAVAALKNTY 279
Score = 37.7 bits (86), Expect = 0.049
Identities = 40/149 (26%), Positives = 57/149 (38%), Gaps = 20/149 (13%)
Query: 742 PQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTD 801
P T S HL D+ + S G D A R V+ +++PR R
Sbjct: 300 PPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR-- 356
Query: 802 GANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVG 861
+ + + + LG I GG + I I GG A G+L+ G
Sbjct: 357 ---------------IVIHRGSTGLGFNIVGGEDGEGIF--ISFILAGGPADLSGELRKG 399
Query: 862 HVILEVNGLTLRGKEHREAARIIAEAFKT 890
IL VNG+ LR H +AA + A +T
Sbjct: 400 DQILSVNGVDLRNASHEQAAIALKNAGQT 428
Score = 32.7 bits (73), Expect = 1.6
Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 817 VRVKKSAATLGIAIEGGANTRQ----PLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTL 872
+ +++ + LG +I GG + P I I GG+A G+L+V IL VN + +
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 873 RGKEHREAARIIAEA 887
R H A + EA
Sbjct: 169 REVTHSAAVEALKEA 183
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 83.6 bits (205), Expect = 8e-16
Identities = 90/287 (31%), Positives = 136/287 (47%), Gaps = 23/287 (8%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQI 188
P +++ ++ K +GLGFSI GG ++H G IYV+ + G A K+G L++GD+I
Sbjct: 150 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
Query: 189 LRVNDKSLARVTHAEAVKALKGSKKLV---LSVYSAGRIPGGYVTNHIYT-WVDPQGRSI 244
L VN L V H +AV ALK + +V ++ S + Y I T + I
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEI 269
Query: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDE----KKVNLVLGDGRS-LGLTIRGGAE 299
S S L + A+ R S + G+E + +V+ G + LG I GG E
Sbjct: 270 SHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG-E 328
Query: 300 YGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKD 358
G GI+I+ + G A+ SG L+ GDQIL VNG N H++A LK++ + +
Sbjct: 329 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
Query: 359 VGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFY 405
++R E K +RE + NS+ G + K GFY
Sbjct: 389 YKPEEYSRF---EAK---IHDLREQLMNSSLGSGTASLRSNPKRGFY 429
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/225 (27%), Positives = 98/225 (43%), Gaps = 51/225 (22%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQIL 189
GE+ + + + GLGFSI GG+++ I+++ + PG A ++G LRV D IL
Sbjct: 56 GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 115
Query: 190 RVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSG 249
VN+ + VTH+ AV+ALK + +V +Y R P I P+G S G
Sbjct: 116 FVNEVDVREVTHSAAVEALKEAGSIV-RLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGG 174
Query: 250 LPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGV 309
+ H + GD IY+T +
Sbjct: 175 VGNQH----------------------------IPGDN---------------SIYVTKI 191
Query: 310 DPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
G A G L++GD+IL VN +++H++AV LK++ ++
Sbjct: 192 IEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236
Score = 37.7 bits (86), Expect = 0.049
Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLT 871
+++ K LG +I GG Q +P + I GG+AH G+L++G IL VN +
Sbjct: 158 IKLIKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
Query: 872 LRGKEHREAARIIAEAF 888
L H +A + +
Sbjct: 217 LEDVMHEDAVAALKNTY 233
Score = 37.7 bits (86), Expect = 0.049
Identities = 40/149 (26%), Positives = 57/149 (38%), Gaps = 20/149 (13%)
Query: 742 PQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTD 801
P T S HL D+ + S G D A R V+ +++PR R
Sbjct: 254 PPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR-- 310
Query: 802 GANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVG 861
+ + + + LG I GG + I I GG A G+L+ G
Sbjct: 311 ---------------IVIHRGSTGLGFNIVGGEDGEGIF--ISFILAGGPADLSGELRKG 353
Query: 862 HVILEVNGLTLRGKEHREAARIIAEAFKT 890
IL VNG+ LR H +AA + A +T
Sbjct: 354 DQILSVNGVDLRNASHEQAAIALKNAGQT 382
Score = 32.7 bits (73), Expect = 1.6
Identities = 23/75 (30%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 817 VRVKKSAATLGIAIEGGANTRQ----PLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTL 872
+ +++ + LG +I GG + P I I GG+A G+L+V IL VN + +
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 873 RGKEHREAARIIAEA 887
R H A + EA
Sbjct: 123 REVTHSAAVEALKEA 137
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 83.2 bits (204), Expect = 1e-15
Identities = 80/241 (33%), Positives = 113/241 (46%), Gaps = 29/241 (12%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQI 188
P +++ ++ K +GLGFSI GG ++H G IYV+ + G A K+G L++GD++
Sbjct: 312 PVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 189 LRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVD-------PQG 241
L VN+ L VTH EAV ALK + VY P N Y D P
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDF---VYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 242 RSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDE-----KKVNLVLGDGRSLGLTIRG 296
+SP S L Q R + + G DE +KV L G LG I G
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSK-----AVLGDDEITREPRKVVLHRG-STGLGFNIVG 482
Query: 297 GAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILT 355
G E G GI+I+ + G A+ SG L+ GD+I+ VN H++A LK++ +
Sbjct: 483 G-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Query: 356 V 356
V
Sbjct: 542 V 542
Score = 65.9 bits (159), Expect = 2e-10
Identities = 59/214 (27%), Positives = 92/214 (42%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG+++ I+++ + G A ++G LRV D ILRVN+ + VT
Sbjct: 229 RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVT 288
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H++AV+ALK + +V +Y R P I P+G S G+ H
Sbjct: 289 HSKAVEALKEAGSIV-RLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQH------ 341
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IY+T + G A G
Sbjct: 342 ----------------------IPGDN---------------SIYVTKIIEGGAAHKDGK 364
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L++GD++L VN + H+EAV LK++ +
Sbjct: 365 LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
Score = 37.7 bits (86), Expect = 0.049
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 6/69 (8%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLT 871
+++ K LG +I GG Q +P + I GG+AH G+L++G +L VN +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 872 LRGKEHREA 880
L H EA
Sbjct: 379 LEEVTHEEA 387
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 10/78 (12%)
Query: 817 VRVKKSAATLGIAIEGGANTRQP-------LPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
+ +++ + LG +I GG + + +I+T GG+A G+L+V IL VN
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIIT---GGAAAQDGRLRVNDCILRVNE 281
Query: 870 LTLRGKEHREAARIIAEA 887
+ +R H +A + EA
Sbjct: 282 VDVRDVTHSKAVEALKEA 299
Score = 33.1 bits (74), Expect = 1.2
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKE 876
V + + + LG I GG + I I GG A G+L+ G I+ VN + LR
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIF--ISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 877 HREAARIIAEA 887
H +AA + A
Sbjct: 525 HEQAAAALKNA 535
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 83.2 bits (204), Expect = 1e-15
Identities = 80/241 (33%), Positives = 113/241 (46%), Gaps = 29/241 (12%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQI 188
P +++ ++ K +GLGFSI GG ++H G IYV+ + G A K+G L++GD++
Sbjct: 312 PVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 189 LRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVD-------PQG 241
L VN+ L VTH EAV ALK + VY P N Y D P
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDF---VYLKVAKPTSMYMNDGYAPPDITNSSSQPVD 428
Query: 242 RSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDE-----KKVNLVLGDGRSLGLTIRG 296
+SP S L Q R + + G DE +KV L G LG I G
Sbjct: 429 NHVSPSSFLGQTPASPARYSPVSK-----AVLGDDEITREPRKVVLHRG-STGLGFNIVG 482
Query: 297 GAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILT 355
G E G GI+I+ + G A+ SG L+ GD+I+ VN H++A LK++ +
Sbjct: 483 G-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Query: 356 V 356
V
Sbjct: 542 V 542
Score = 65.9 bits (159), Expect = 2e-10
Identities = 59/214 (27%), Positives = 92/214 (42%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG+++ I+++ + G A ++G LRV D ILRVN+ + VT
Sbjct: 229 RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVT 288
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H++AV+ALK + +V +Y R P I P+G S G+ H
Sbjct: 289 HSKAVEALKEAGSIV-RLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQH------ 341
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IY+T + G A G
Sbjct: 342 ----------------------IPGDN---------------SIYVTKIIEGGAAHKDGK 364
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L++GD++L VN + H+EAV LK++ +
Sbjct: 365 LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398
Score = 37.7 bits (86), Expect = 0.049
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 6/69 (8%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLT 871
+++ K LG +I GG Q +P + I GG+AH G+L++G +L VN +
Sbjct: 320 IKLIKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVC 378
Query: 872 LRGKEHREA 880
L H EA
Sbjct: 379 LEEVTHEEA 387
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 10/78 (12%)
Query: 817 VRVKKSAATLGIAIEGGANTRQP-------LPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
+ +++ + LG +I GG + + +I+T GG+A G+L+V IL VN
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIIT---GGAAAQDGRLRVNDCILRVNE 281
Query: 870 LTLRGKEHREAARIIAEA 887
+ +R H +A + EA
Sbjct: 282 VDVRDVTHSKAVEALKEA 299
Score = 33.1 bits (74), Expect = 1.2
Identities = 23/71 (32%), Positives = 33/71 (46%), Gaps = 2/71 (2%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKE 876
V + + + LG I GG + I I GG A G+L+ G I+ VN + LR
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIF--ISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 877 HREAARIIAEA 887
H +AA + A
Sbjct: 525 HEQAAAALKNA 535
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 80.9 bits (198), Expect = 5e-15
Identities = 87/278 (31%), Positives = 123/278 (44%), Gaps = 64/278 (23%)
Query: 140 LVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQILRVND 193
+V ++ K +GLGFSI GG ++H G IYV+ + G A+K+G L+VGD++L VN+
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 194 KSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQG-----RSISPP- 247
SL VTH EAV LK + ++V G+ Y+T DP G S SPP
Sbjct: 200 YSLEEVTHEEAVAILKNTSEVV--YLKVGKPTTIYMT-------DPYGPPDITHSYSPPM 250
Query: 248 ---------------SGLP-----------------------QPHGGALRQQEGDRRSTL 269
+ LP H A RQ + +
Sbjct: 251 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAV 310
Query: 270 HLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILE 328
L G+ +KV L G LG I GG E G GI+++ + G A+ SG L+ GDQIL
Sbjct: 311 SL--EGEPRKVVLHKG-STGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILS 366
Query: 329 VNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHAR 366
VNG H++A LK + + + +AR
Sbjct: 367 VNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYAR 404
Score = 76.6 bits (187), Expect = 9e-14
Identities = 62/214 (28%), Positives = 100/214 (46%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG+++ GI+++ + PG A ++G LRV D ILRVN+ ++ V+
Sbjct: 52 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 111
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H++AV+ALK + +V +Y R P I + P+G S G+ H
Sbjct: 112 HSKAVEALKEAGSIV-RLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH------ 164
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IY+T + G A+ G
Sbjct: 165 ----------------------IPGDN---------------SIYVTKIIDGGAAQKDGR 187
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L+VGD++L VN S + H+EAV +LK++ ++
Sbjct: 188 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 221
Score = 57.8 bits (138), Expect = 5e-08
Identities = 47/114 (41%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 104 LLFDQYTAEGLYLPATTPYRQPAWGGPDSAG-PGEVRLVSLRRAKAHEGLGFSIRGGSEH 162
L+ D YT+ + AT RQP+ + GE R V L K GLGF+I GG E
Sbjct: 284 LVDDDYTSHSQHSTAT---RQPSMTLQRAVSLEGEPRKVVLH--KGSTGLGFNIVGG-ED 337
Query: 163 GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALKGSKKLV 215
G GI+VS + G A+ G L+ GDQIL VN L +H +A ALKG+ + V
Sbjct: 338 GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 391
Score = 40.4 bits (93), Expect = 0.008
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 810 LEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
LE V + K + LG I GG + + I GG A G+L+ G IL VNG
Sbjct: 312 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF--VSFILAGGPADLSGELQRGDQILSVNG 369
Query: 870 LTLRGKEHREAARIIAEAFKT 890
+ LRG H +AA + A +T
Sbjct: 370 IDLRGASHEQAAAALKGAGQT 390
Score = 36.2 bits (82), Expect = 0.14
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 8/77 (10%)
Query: 815 TLVRVK--KSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEV 867
T+V +K K LG +I GG Q +P + I GG+A G+L+VG +L V
Sbjct: 139 TVVEIKLFKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 197
Query: 868 NGLTLRGKEHREAARII 884
N +L H EA I+
Sbjct: 198 NNYSLEEVTHEEAVAIL 214
Score = 32.3 bits (72), Expect = 2.1
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 817 VRVKKSAATLGIAIEGGANTRQ----PLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTL 872
+ +++ + LG +I GG + P I I GG+A G+L+V IL VN + +
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 873 RGKEHREAARIIAEA 887
H +A + EA
Sbjct: 108 SEVSHSKAVEALKEA 122
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 78.6 bits (192), Expect = 2e-14
Identities = 91/299 (30%), Positives = 139/299 (46%), Gaps = 40/299 (13%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQI 188
P ++ + K +GLGFSI GG ++H G IY++ + G A+K+G L++GD++
Sbjct: 219 PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
Query: 189 LRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIY-------TWVDPQG 241
L VN+ +L V H EAV +LK + + VY PG N +Y T+
Sbjct: 279 LAVNNTNLQDVRHEEAVASLKNTSDM---VYLKVAKPGSLHLNDMYAPPDYASTFTALAD 335
Query: 242 RSISPPSGLPQPHGGALR---------QQEGDRRSTL--HLLQGGD--EKKVNLVLGDGR 288
IS S L + GA+ Q R S + H+L D + ++L G
Sbjct: 336 NHISHNSSL--GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGS 393
Query: 289 S-LGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLL 346
+ LG I GG E G GI+++ + G A+ SG L+ GD+IL VNG + N H++A L
Sbjct: 394 TGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452
Query: 347 KSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGDLTTEGINKPGFY 405
K + + V ++R E+K +RE M NS+ G + K Y
Sbjct: 453 KRAGQSVTIVAQYRPEEYSRF---ESK---IHDLREQMMNSSMSSGSGSLRTSEKRSLY 505
Score = 67.0 bits (162), Expect = 8e-11
Identities = 58/214 (27%), Positives = 93/214 (43%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG ++ GI+++ + PG A +G L V D +LRVN+ ++ V
Sbjct: 136 RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVV 195
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H+ AV+ALK + +V V R P + P+G S G+ H
Sbjct: 196 HSRAVEALKEAGPVVRLVVRR-RQPPPETIMEVNLLKGPKGLGFSIAGGIGNQH------ 248
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IYIT + G A+ G
Sbjct: 249 ----------------------IPGDN---------------SIYITKIIEGGAAQKDGR 271
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L++GD++L VN + ++ H+EAV LK++ ++
Sbjct: 272 LQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMV 305
Score = 37.7 bits (86), Expect = 0.049
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 11/92 (11%)
Query: 812 PTSTLVRVK--KSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVI 864
P T++ V K LG +I GG Q +P I I GG+A G+L++G +
Sbjct: 220 PPETIMEVNLLKGPKGLGFSIAGGIGN-QHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
Query: 865 LEVNGLTLRGKEHREAARIIAEAFKTKDRDYI 896
L VN L+ H EA +A T D Y+
Sbjct: 279 LAVNNTNLQDVRHEEA---VASLKNTSDMVYL 307
Score = 37.7 bits (86), Expect = 0.049
Identities = 45/167 (26%), Positives = 75/167 (44%), Gaps = 17/167 (10%)
Query: 722 VMVEVHRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSG-VDAGEAEASAPGRGR 780
V ++V +P S +N++ A P AST + L+D+ + + G + A E++ S P +
Sbjct: 305 VYLKVAKPGSL-HLNDMYAPPDY--ASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQ 361
Query: 781 QSVSTKSRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPL 840
+ S +PR+ + + P + + K + LG I GG +
Sbjct: 362 VPPTRYS----PIPRHMLAEEDFTREP-------RKIILHKGSTGLGFNIVGGEDGEGIF 410
Query: 841 PRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEA 887
+ I GG A G+L+ G IL VNG+ LR H +AA + A
Sbjct: 411 --VSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 455
>gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
Length = 1601
Score = 78.2 bits (191), Expect = 3e-14
Identities = 37/68 (54%), Positives = 52/68 (76%)
Query: 290 LGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
L ++ GG+E G GI++ GV+PGS+A SGLK GDQI+EVNG++F NI +AV +L+++
Sbjct: 542 LQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNN 601
Query: 350 RHLILTVK 357
HL LTVK
Sbjct: 602 THLALTVK 609
Score = 74.7 bits (182), Expect = 4e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 15/165 (9%)
Query: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
A + R V L++A L FS+ GGSE G GI+V VEPGS A GL+ GDQI+ VN
Sbjct: 523 AAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVN 582
Query: 193 DKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQ 252
++ +T +AV+ L+ + L L+ V +I+ + + R+ SG+
Sbjct: 583 GQNFENITFMKAVEILRNNTHLALT-----------VKTNIFVFKELLFRTEQEKSGV-- 629
Query: 253 PHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGG 297
PH + +++ +R S H+ GD ++ + G + T+ GG
Sbjct: 630 PHIPKIAEKKSNRHSIQHV--PGDIEQTSQEKGSKKVKANTVSGG 672
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 76.6 bits (187), Expect = 9e-14
Identities = 62/214 (28%), Positives = 100/214 (46%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG+++ GI+++ + PG A ++G LRV D ILRVN+ ++ V+
Sbjct: 208 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 267
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H++AV+ALK + +V +Y R P I + P+G S G+ H
Sbjct: 268 HSKAVEALKEAGSIV-RLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH------ 320
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IY+T + G A+ G
Sbjct: 321 ----------------------IPGDN---------------SIYVTKIIDGGAAQKDGR 343
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L+VGD++L VN S + H+EAV +LK++ ++
Sbjct: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 377
Score = 60.8 bits (146), Expect = 5e-09
Identities = 47/119 (39%), Positives = 66/119 (55%), Gaps = 20/119 (16%)
Query: 140 LVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQILRVND 193
+V ++ K +GLGFSI GG ++H G IYV+ + G A+K+G L+VGD++L VN+
Sbjct: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
Query: 194 KSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQG-----RSISPP 247
SL VTH EAV LK + ++V G+ Y+T DP G S SPP
Sbjct: 356 YSLEEVTHEEAVAILKNTSEVV--YLKVGKPTTIYMT-------DPYGPPDITHSYSPP 405
Score = 54.3 bits (129), Expect = 5e-07
Identities = 38/81 (46%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDK 194
GE R V L K GLGF+I GG E G GI+VS + G A+ G L+ GDQIL VN
Sbjct: 522 GEPRKVVLH--KGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGI 578
Query: 195 SLARVTHAEAVKALKGSKKLV 215
L +H +A ALKG+ + V
Sbjct: 579 DLRGASHEQAAAALKGAGQTV 599
Score = 43.9 bits (102), Expect = 7e-04
Identities = 38/114 (33%), Positives = 54/114 (47%), Gaps = 5/114 (4%)
Query: 254 HGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGS 313
H A RQ + + L G+ +KV L G LG I GG E G GI+++ + G
Sbjct: 503 HSTATRQPSMTLQRAVSL--EGEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGG 558
Query: 314 EAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHAR 366
A+ SG L+ GDQIL VNG H++A LK + + + +AR
Sbjct: 559 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYAR 612
Score = 40.4 bits (93), Expect = 0.008
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 810 LEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
LE V + K + LG I GG + + I GG A G+L+ G IL VNG
Sbjct: 520 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF--VSFILAGGPADLSGELQRGDQILSVNG 577
Query: 870 LTLRGKEHREAARIIAEAFKT 890
+ LRG H +AA + A +T
Sbjct: 578 IDLRGASHEQAAAALKGAGQT 598
Score = 36.2 bits (82), Expect = 0.14
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 8/77 (10%)
Query: 815 TLVRVK--KSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEV 867
T+V +K K LG +I GG Q +P + I GG+A G+L+VG +L V
Sbjct: 295 TVVEIKLFKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 353
Query: 868 NGLTLRGKEHREAARII 884
N +L H EA I+
Sbjct: 354 NNYSLEEVTHEEAVAIL 370
Score = 32.3 bits (72), Expect = 2.1
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 817 VRVKKSAATLGIAIEGGANTRQ----PLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTL 872
+ +++ + LG +I GG + P I I GG+A G+L+V IL VN + +
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 873 RGKEHREAARIIAEA 887
H +A + EA
Sbjct: 264 SEVSHSKAVEALKEA 278
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 76.6 bits (187), Expect = 9e-14
Identities = 62/214 (28%), Positives = 100/214 (46%), Gaps = 51/214 (23%)
Query: 147 KAHEGLGFSIRGGSEH-----GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVT 200
+ + GLGFSI GG+++ GI+++ + PG A ++G LRV D ILRVN+ ++ V+
Sbjct: 103 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 162
Query: 201 HAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQ 260
H++AV+ALK + +V +Y R P I + P+G S G+ H
Sbjct: 163 HSKAVEALKEAGSIV-RLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQH------ 215
Query: 261 QEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG- 319
+ GD IY+T + G A+ G
Sbjct: 216 ----------------------IPGDN---------------SIYVTKIIDGGAAQKDGR 238
Query: 320 LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
L+VGD++L VN S + H+EAV +LK++ ++
Sbjct: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 272
Score = 60.8 bits (146), Expect = 5e-09
Identities = 47/119 (39%), Positives = 66/119 (55%), Gaps = 20/119 (16%)
Query: 140 LVSLRRAKAHEGLGFSIRGG--SEHGVG---IYVSLVEPGSLAEKEG-LRVGDQILRVND 193
+V ++ K +GLGFSI GG ++H G IYV+ + G A+K+G L+VGD++L VN+
Sbjct: 191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250
Query: 194 KSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQG-----RSISPP 247
SL VTH EAV LK + ++V G+ Y+T DP G S SPP
Sbjct: 251 YSLEEVTHEEAVAILKNTSEVV--YLKVGKPTTIYMT-------DPYGPPDITHSYSPP 300
Score = 54.3 bits (129), Expect = 5e-07
Identities = 38/81 (46%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDK 194
GE R V L K GLGF+I GG E G GI+VS + G A+ G L+ GDQIL VN
Sbjct: 417 GEPRKVVLH--KGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGI 473
Query: 195 SLARVTHAEAVKALKGSKKLV 215
L +H +A ALKG+ + V
Sbjct: 474 DLRGASHEQAAAALKGAGQTV 494
Score = 43.9 bits (102), Expect = 7e-04
Identities = 38/114 (33%), Positives = 54/114 (47%), Gaps = 5/114 (4%)
Query: 254 HGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGS 313
H A RQ + + L G+ +KV L G LG I GG E G GI+++ + G
Sbjct: 398 HSTATRQPSMTLQRAVSL--EGEPRKVVLHKGS-TGLGFNIVGG-EDGEGIFVSFILAGG 453
Query: 314 EAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHAR 366
A+ SG L+ GDQIL VNG H++A LK + + + +AR
Sbjct: 454 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYAR 507
Score = 40.4 bits (93), Expect = 0.008
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 810 LEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
LE V + K + LG I GG + + I GG A G+L+ G IL VNG
Sbjct: 415 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF--VSFILAGGPADLSGELQRGDQILSVNG 472
Query: 870 LTLRGKEHREAARIIAEAFKT 890
+ LRG H +AA + A +T
Sbjct: 473 IDLRGASHEQAAAALKGAGQT 493
Score = 36.2 bits (82), Expect = 0.14
Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 8/77 (10%)
Query: 815 TLVRVK--KSAATLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEV 867
T+V +K K LG +I GG Q +P + I GG+A G+L+VG +L V
Sbjct: 190 TVVEIKLFKGPKGLGFSIAGGVGN-QHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 248
Query: 868 NGLTLRGKEHREAARII 884
N +L H EA I+
Sbjct: 249 NNYSLEEVTHEEAVAIL 265
Score = 32.3 bits (72), Expect = 2.1
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 817 VRVKKSAATLGIAIEGGANTRQ----PLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTL 872
+ +++ + LG +I GG + P I I GG+A G+L+V IL VN + +
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 873 RGKEHREAARIIAEA 887
H +A + EA
Sbjct: 159 SEVSHSKAVEALKEA 173
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 75.5 bits (184), Expect = 2e-13
Identities = 77/234 (32%), Positives = 105/234 (44%), Gaps = 71/234 (30%)
Query: 134 GPGEVRLVSLRRAKAHEGLGFSIRGGSEH-----GV---GIYVSLVEPGSLAEKEGLRVG 185
GP V + L RA LG SI GGS+H GV G+++S V P LA + GLRVG
Sbjct: 998 GPYPVEEIRLPRAGGP--LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG 1055
Query: 186 DQILRVNDKSLARVTHAEAVKA-LKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSI 244
D+IL VN + + TH EAV A L+ +L L V R
Sbjct: 1056 DRILAVNGQDVRDATHQEAVSALLRPCLELSLLV-----------------------RRD 1092
Query: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAE----- 299
P GL + +++ G+R LG++IRGGA
Sbjct: 1093 PAPPGLREL---CIQKAPGER------------------------LGISIRGGARGHAGN 1125
Query: 300 ----YGLGIYITGVDP-GSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348
GI+I+ V P G+ L+VG ++LEVN +S L + H EAV+LL+S
Sbjct: 1126 PRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
Score = 73.9 bits (180), Expect = 6e-13
Identities = 76/251 (30%), Positives = 112/251 (44%), Gaps = 34/251 (13%)
Query: 130 PDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH------GVGIYVSLVEPGSLAEKEG-L 182
P+S GP R V+ A++ GLGFSI GG GI+VS + G A + G L
Sbjct: 851 PESPGPLRQRHVACL-ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTL 909
Query: 183 RVGDQILRVNDKSLARVTHAEAVKALKGSKK---LVLSVYSAGRIPGGYVTNHIYTWVDP 239
+VGD++L +N + H AV L + L+L + G +P + +
Sbjct: 910 QVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 240 QGRSISPPS----GLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIR 295
SI+ + GLP L L+G + + G LGL+I
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAA----------LEGPYPVEEIRLPRAGGPLGLSIV 1019
Query: 296 GGAEYGL--------GIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAV-RLL 346
GG+++ G++I+ V P A SGL+VGD+IL VNG+ + H EAV LL
Sbjct: 1020 GGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALL 1079
Query: 347 KSSRHLILTVK 357
+ L L V+
Sbjct: 1080 RPCLELSLLVR 1090
Score = 68.9 bits (167), Expect = 2e-11
Identities = 71/234 (30%), Positives = 104/234 (44%), Gaps = 42/234 (17%)
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSEH------GVGIYVSLVEPGSLAEKEGLRVGDQILR 190
E+ L LR+ GLG SI GG GI++S V A + G+RVGD++L
Sbjct: 726 ELTLTILRQTG---GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLE 782
Query: 191 VNDKSLARVTHAEAVKALKGSKKLV-LSVYSAGRI-PGGYVT------NHIYTWVDPQGR 242
VN +L H EAV+AL+G+ V + V+ + P VT Y+ + +G
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGG 842
Query: 243 SISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGG----- 297
+ P LP G LRQ + V + R LG +I GG
Sbjct: 843 GLRLPL-LPPESPGPLRQ-----------------RHVACLARSERGLGFSIAGGKGSTP 884
Query: 298 -AEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
GI+++ + G A +G L+VGD++L +NG HD AV LL ++
Sbjct: 885 YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA 938
Score = 50.4 bits (119), Expect = 7e-06
Identities = 36/89 (40%), Positives = 52/89 (58%), Gaps = 12/89 (13%)
Query: 131 DSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVG---------IYVSLVEPGSLAEKEG 181
D A PG +R + +++A E LG SIRGG+ G I++S V P A ++G
Sbjct: 1092 DPAPPG-LRELCIQKAPG-ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDG 1149
Query: 182 -LRVGDQILRVNDKSLARVTHAEAVKALK 209
LRVG ++L VN +SL +TH EAV+ L+
Sbjct: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/87 (37%), Positives = 44/87 (50%), Gaps = 12/87 (13%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGA-----NTRQPLPRIVTIQR---GGSAHNCGQ 857
PPGL E L K LGI+I GGA N R P + I + G+A G+
Sbjct: 1095 PPGLRE----LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGR 1150
Query: 858 LKVGHVILEVNGLTLRGKEHREAARII 884
L+VG +LEVN +L G H EA +++
Sbjct: 1151 LRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 38.9 bits (89), Expect = 0.022
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 14/128 (10%)
Query: 768 AGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANK---PPGLLEPTSTLVRVKKSAA 824
A E EAS ++ + S K + D AN P +E + + +
Sbjct: 682 AEEEEASTEEEDKEGAVVSAPSVKGVS-----FDQANNLLIEPARIEEEELTLTILRQTG 736
Query: 825 TLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHRE 879
LGI+I GG + I + G A G ++VG +LEVNG+ L+G EH E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 880 AARIIAEA 887
A + A
Sbjct: 796 AVEALRGA 803
Score = 37.0 bits (84), Expect = 0.083
Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 14/118 (11%)
Query: 785 TKSRSSKELPRNERPTDGANKPPGLLEPTST-------LVRVKKSAATLGIAIEGGANTR 837
T R + ER G P LL P S + + +S LG +I GG +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLP--LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGST 883
Query: 838 QPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKT 890
+ I GG+AH G L+VG +L +NG+ + H A ++ A T
Sbjct: 884 PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Score = 32.3 bits (72), Expect = 2.1
Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 8/71 (11%)
Query: 817 VRVKKSAATLGIAIEGGAN-------TRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
+R+ ++ LG++I GG++ ++P I + G A G L+VG IL VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 870 LTLRGKEHREA 880
+R H+EA
Sbjct: 1064 QDVRDATHQEA 1074
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 75.5 bits (184), Expect = 2e-13
Identities = 77/234 (32%), Positives = 105/234 (44%), Gaps = 71/234 (30%)
Query: 134 GPGEVRLVSLRRAKAHEGLGFSIRGGSEH-----GV---GIYVSLVEPGSLAEKEGLRVG 185
GP V + L RA LG SI GGS+H GV G+++S V P LA + GLRVG
Sbjct: 998 GPYPVEEIRLPRAGGP--LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG 1055
Query: 186 DQILRVNDKSLARVTHAEAVKA-LKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSI 244
D+IL VN + + TH EAV A L+ +L L V R
Sbjct: 1056 DRILAVNGQDVRDATHQEAVSALLRPCLELSLLV-----------------------RRD 1092
Query: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAE----- 299
P GL + +++ G+R LG++IRGGA
Sbjct: 1093 PAPPGLREL---CIQKAPGER------------------------LGISIRGGARGHAGN 1125
Query: 300 ----YGLGIYITGVDP-GSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348
GI+I+ V P G+ L+VG ++LEVN +S L + H EAV+LL+S
Sbjct: 1126 PRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179
Score = 73.9 bits (180), Expect = 6e-13
Identities = 76/251 (30%), Positives = 112/251 (44%), Gaps = 34/251 (13%)
Query: 130 PDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEH------GVGIYVSLVEPGSLAEKEG-L 182
P+S GP R V+ A++ GLGFSI GG GI+VS + G A + G L
Sbjct: 851 PESPGPLRQRHVACL-ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTL 909
Query: 183 RVGDQILRVNDKSLARVTHAEAVKALKGSKK---LVLSVYSAGRIPGGYVTNHIYTWVDP 239
+VGD++L +N + H AV L + L+L + G +P + +
Sbjct: 910 QVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAV 969
Query: 240 QGRSISPPS----GLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIR 295
SI+ + GLP L L+G + + G LGL+I
Sbjct: 970 ATTSITTATPGVPGLPSLAPSLLAAA----------LEGPYPVEEIRLPRAGGPLGLSIV 1019
Query: 296 GGAEYGL--------GIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAV-RLL 346
GG+++ G++I+ V P A SGL+VGD+IL VNG+ + H EAV LL
Sbjct: 1020 GGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALL 1079
Query: 347 KSSRHLILTVK 357
+ L L V+
Sbjct: 1080 RPCLELSLLVR 1090
Score = 68.9 bits (167), Expect = 2e-11
Identities = 71/234 (30%), Positives = 104/234 (44%), Gaps = 42/234 (17%)
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSEH------GVGIYVSLVEPGSLAEKEGLRVGDQILR 190
E+ L LR+ GLG SI GG GI++S V A + G+RVGD++L
Sbjct: 726 ELTLTILRQTG---GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLE 782
Query: 191 VNDKSLARVTHAEAVKALKGSKKLV-LSVYSAGRI-PGGYVT------NHIYTWVDPQGR 242
VN +L H EAV+AL+G+ V + V+ + P VT Y+ + +G
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGG 842
Query: 243 SISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGG----- 297
+ P LP G LRQ + V + R LG +I GG
Sbjct: 843 GLRLPL-LPPESPGPLRQ-----------------RHVACLARSERGLGFSIAGGKGSTP 884
Query: 298 -AEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
GI+++ + G A +G L+VGD++L +NG HD AV LL ++
Sbjct: 885 YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA 938
Score = 50.4 bits (119), Expect = 7e-06
Identities = 36/89 (40%), Positives = 52/89 (58%), Gaps = 12/89 (13%)
Query: 131 DSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVG---------IYVSLVEPGSLAEKEG 181
D A PG +R + +++A E LG SIRGG+ G I++S V P A ++G
Sbjct: 1092 DPAPPG-LRELCIQKAPG-ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDG 1149
Query: 182 -LRVGDQILRVNDKSLARVTHAEAVKALK 209
LRVG ++L VN +SL +TH EAV+ L+
Sbjct: 1150 RLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/87 (37%), Positives = 44/87 (50%), Gaps = 12/87 (13%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGA-----NTRQPLPRIVTIQR---GGSAHNCGQ 857
PPGL E L K LGI+I GGA N R P + I + G+A G+
Sbjct: 1095 PPGLRE----LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGR 1150
Query: 858 LKVGHVILEVNGLTLRGKEHREAARII 884
L+VG +LEVN +L G H EA +++
Sbjct: 1151 LRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 38.9 bits (89), Expect = 0.022
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 14/128 (10%)
Query: 768 AGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANK---PPGLLEPTSTLVRVKKSAA 824
A E EAS ++ + S K + D AN P +E + + +
Sbjct: 682 AEEEEASTEEEDKEGAVVSAPSVKGVS-----FDQANNLLIEPARIEEEELTLTILRQTG 736
Query: 825 TLGIAIEGGANTRQPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHRE 879
LGI+I GG + I + G A G ++VG +LEVNG+ L+G EH E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 880 AARIIAEA 887
A + A
Sbjct: 796 AVEALRGA 803
Score = 37.0 bits (84), Expect = 0.083
Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 14/118 (11%)
Query: 785 TKSRSSKELPRNERPTDGANKPPGLLEPTST-------LVRVKKSAATLGIAIEGGANTR 837
T R + ER G P LL P S + + +S LG +I GG +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLP--LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGST 883
Query: 838 QPLPR-----IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKT 890
+ I GG+AH G L+VG +L +NG+ + H A ++ A T
Sbjct: 884 PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPT 941
Score = 32.3 bits (72), Expect = 2.1
Identities = 23/71 (32%), Positives = 37/71 (52%), Gaps = 8/71 (11%)
Query: 817 VRVKKSAATLGIAIEGGAN-------TRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNG 869
+R+ ++ LG++I GG++ ++P I + G A G L+VG IL VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 870 LTLRGKEHREA 880
+R H+EA
Sbjct: 1064 QDVRDATHQEA 1074
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 72.0 bits (175), Expect = 2e-12
Identities = 66/224 (29%), Positives = 102/224 (45%), Gaps = 15/224 (6%)
Query: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHG-VGIYVSLVEPGSLAEKEGLRVGDQILR 190
+AG RL L K G GF + G E G +G Y+ LVEPGS AEK GL GD+++
Sbjct: 6 AAGAPLPRLCCLE--KGPNGYGFHLHG--EKGKLGQYIRLVEPGSPAEKAGLLAGDRLVE 61
Query: 191 VNDKSLARVTHAEAVK----ALKGSKKLVLSVYSAGRIP--GGYVTNHIYTWVDPQGRSI 244
VN +++ + TH + V AL + LV+ + ++ G V + + G++
Sbjct: 62 VNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAE 121
Query: 245 SPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGI 304
P + Q G +E D+ H Q ++ + G + G
Sbjct: 122 PPAAAEVQGAGNENEPREADKS---HPEQRELRPRLCTMKKGPSGYGFNLHSDKSKP-GQ 177
Query: 305 YITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348
+I VDP S AE SGL+ D+I+EVNG H + V +++
Sbjct: 178 FIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRA 221
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/57 (36%), Positives = 35/57 (61%)
Query: 297 GAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
G + LG YI V+PGS AE +GL GD+++EVNG + H + V ++++ + +
Sbjct: 30 GEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAV 86
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 72.0 bits (175), Expect = 2e-12
Identities = 74/261 (28%), Positives = 120/261 (45%), Gaps = 43/261 (16%)
Query: 132 SAGPG----EVRLVSLRRAKAHEGLGFSIRGG--------SEHGVGIYVS-LVEPGSLAE 178
+A PG E + ++L + LGF+I GG GI+VS +V+ G A+
Sbjct: 235 AAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAK 294
Query: 179 KEGLRVGDQILRVNDKSLARVTHAEAVKALKGSK--------------KLVLSVYSAGRI 224
+ GL++ D+I+ VN + L+R TH +AV+A K +K K+ + +
Sbjct: 295 EGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLV 354
Query: 225 PGGYVTNHIYTWVDPQGRSISP------PSGLPQPHGGALRQQE-GDRRSTLHLLQGGDE 277
G T+ + + + SP P LP+ H A + D +H +E
Sbjct: 355 DTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQEMDREE 414
Query: 278 KKVNLV----LGDGRSLGLTI--RGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVN 330
++ V + LGLT+ R E +GIYI+ +DP S A G ++ GD+I+++N
Sbjct: 415 LELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQIN 474
Query: 331 GRSFLNILHDEAVRLLKSSRH 351
G N +EAV LL S +
Sbjct: 475 GIEVQN--REEAVALLTSEEN 493
Score = 51.6 bits (122), Expect = 3e-06
Identities = 64/246 (26%), Positives = 101/246 (41%), Gaps = 29/246 (11%)
Query: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEP--GSLAEKEGLRVGDQILR 190
AG G+V L A + G + G G+ ++ E G LR + L+
Sbjct: 115 AGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQ 174
Query: 191 VNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGL 250
+L + EA++A K K LV + +A + + + R S +
Sbjct: 175 ARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCV 234
Query: 251 PQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLG-DGRSLGLTIRGG--------AEYG 301
P GG +G + K + LVL D SLG I GG
Sbjct: 235 AAPPGG----------------KGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSS 278
Query: 302 LGIYITG-VDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVG 360
GI+++ VD G A+ GL++ D+I+EVNGR HD+AV K+++ I+ V+ +
Sbjct: 279 EGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIV-VQVLR 337
Query: 361 RLPHAR 366
R P +
Sbjct: 338 RTPRTK 343
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/68 (50%), Positives = 49/68 (72%)
Query: 290 LGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
L + GG+E G GI++ VD GS+A +GLK GDQILEVNG++F NI +A+ +L+++
Sbjct: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
Query: 350 RHLILTVK 357
HL +TVK
Sbjct: 457 THLSITVK 464
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/86 (36%), Positives = 51/86 (59%)
Query: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
A + RL++L + L F + GGSE G GI+V V+ GS A + GL+ GDQIL VN
Sbjct: 378 AAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVN 437
Query: 193 DKSLARVTHAEAVKALKGSKKLVLSV 218
++ + ++A++ L+ + L ++V
Sbjct: 438 GQNFENIQLSKAMEILRNNTHLSITV 463
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/68 (50%), Positives = 49/68 (72%)
Query: 290 LGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
L + GG+E G GI++ VD GS+A +GLK GDQILEVNG++F NI +A+ +L+++
Sbjct: 397 LPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNN 456
Query: 350 RHLILTVK 357
HL +TVK
Sbjct: 457 THLSITVK 464
Score = 57.8 bits (138), Expect = 5e-08
Identities = 31/86 (36%), Positives = 51/86 (59%)
Query: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
A + RL++L + L F + GGSE G GI+V V+ GS A + GL+ GDQIL VN
Sbjct: 378 AAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVN 437
Query: 193 DKSLARVTHAEAVKALKGSKKLVLSV 218
++ + ++A++ L+ + L ++V
Sbjct: 438 GQNFENIQLSKAMEILRNNTHLSITV 463
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 68.6 bits (166), Expect = 3e-11
Identities = 69/224 (30%), Positives = 109/224 (48%), Gaps = 33/224 (14%)
Query: 138 VRLVSLRRAKAHEGLGFSIRGGSEHGVG---IYVSLVEP-GSLAEKEGLRVGDQILRVND 193
+R V +++ + LG SI GG +G I+++++ P G A+ + LRVGD+I+ +
Sbjct: 1831 LRTVEMKKGPT-DSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICG 1889
Query: 194 KSLARVTHAEAVKALKG-SKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQ 252
S +TH +AV LK S + + V + G + VT H +P S+S +GL
Sbjct: 1890 TSTEGMTHTQAVNLLKNASGSIEMQVVAGGDV--SVVTGHQQ---EPASSSLSF-TGLTS 1943
Query: 253 PHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYG-----LGIYIT 307
+ G + L+ G + LG +I GG YG L IY+
Sbjct: 1944 --SSIFQDDLGPPQCKSITLERGPD-----------GLGFSIVGG--YGSPHGDLPIYVK 1988
Query: 308 GV-DPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSR 350
V G+ +E LK GDQI+ VNG+S + H+EAV +LK ++
Sbjct: 1989 TVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTK 2032
Score = 60.8 bits (146), Expect = 5e-09
Identities = 68/229 (29%), Positives = 97/229 (42%), Gaps = 34/229 (14%)
Query: 143 LRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHA 202
L K GLG +I I SL E G A L+VGDQIL V+D+ +
Sbjct: 1484 LELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIE 1543
Query: 203 EAVKALKGSKKLVL-----------SVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLP 251
+ + LK +K V +V SA G N + + PQ SG P
Sbjct: 1544 KFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQ-------SGSP 1596
Query: 252 QPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLG--------DGRS-LGLTIRGGAEYGL 302
+P ++R RS+ + D ++ G GR+ LGL+I GG++ L
Sbjct: 1597 EPE--SIRNTS---RSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL 1651
Query: 303 GIYITG--VDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
G I + G+ + L GDQILEVNG HDEA+ +L+ +
Sbjct: 1652 GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQT 1700
Score = 58.9 bits (141), Expect = 2e-08
Identities = 41/89 (46%), Positives = 53/89 (59%), Gaps = 6/89 (6%)
Query: 131 DSAGPGEVRLVSLRRAKAHEGLGFSIRGG--SEHG-VGIYVSLVEPGSLAEKEG-LRVGD 186
D GP + + ++L R +GLGFSI GG S HG + IYV V A ++G L+ GD
Sbjct: 1949 DDLGPPQCKSITLERGP--DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGD 2006
Query: 187 QILRVNDKSLARVTHAEAVKALKGSKKLV 215
QI+ VN +SL VTH EAV LK +K V
Sbjct: 2007 QIIAVNGQSLEGVTHEEAVAILKRTKGTV 2035
Score = 58.2 bits (139), Expect = 3e-08
Identities = 59/237 (24%), Positives = 108/237 (45%), Gaps = 21/237 (8%)
Query: 146 AKAHEGLGFSIRGGSEHGVGIYV-SLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEA 204
AK + LG ++ + G+G+ V S++ G+++ + +GD IL +N++S VT+A+A
Sbjct: 1012 AKGNSSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQA 1070
Query: 205 VKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSI-----SPPSGLPQPHGGALR 259
+A+ L+ +P ++ + GR + S +G P
Sbjct: 1071 -RAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPERE 1129
Query: 260 QQEGDRRSTLHLLQG--GDEKKVNLVLGDGRSLGLTIRGGAEYG---------LGIYITG 308
+ EG+ + ++V L +SLG++I GG G GI+I
Sbjct: 1130 EGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKH 1189
Query: 309 VDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLL-KSSRHLILTVKDVGRLP 363
V S A +G LK GD+I+EV+G + H++AV + K+ ++ V+ + P
Sbjct: 1190 VLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRP 1246
Score = 57.0 bits (136), Expect = 8e-08
Identities = 60/208 (28%), Positives = 89/208 (42%), Gaps = 49/208 (23%)
Query: 146 AKAHEGLGFSIRGGSEHGVGIYV--SLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAE 203
+K GLG SI GGS+ +G + + E G+ + L GDQIL VN L + TH E
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
Query: 204 AVKALKGSKKLV-LSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQE 262
A+ L+ + + V L++Y R +P +++E
Sbjct: 1693 AINVLRQTPQRVRLTLY----------------------RDEAP-----------YKEEE 1719
Query: 263 GDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LK 321
T+ L +KK G+ LGL+I G G++++ + G A+ G L
Sbjct: 1720 VCDTLTIEL-----QKK------PGKGLGLSI-VGKRNDTGVFVSDIVKGGIADADGRLM 1767
Query: 322 VGDQILEVNGRSFLNILHDEAVRLLKSS 349
GDQIL VNG N + LLK S
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAALLKVS 1795
Score = 56.6 bits (135), Expect = 1e-07
Identities = 57/204 (27%), Positives = 94/204 (46%), Gaps = 34/204 (16%)
Query: 151 GLGFSI---RGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLAR-VTHAEAV 205
GLGFS+ R + +GI+V ++ GS+A ++G L+ DQIL +N ++L + +TH +A+
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 206 KALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDP-QGRSISPPSGLPQPHGGALRQQEGD 264
L+ +K V V + G +P V P RS S S + H + Q
Sbjct: 207 SILQKAKDTVQLVIARGSLP---------QLVSPIVSRSPSAASTI-SAHSNPVHWQ--- 253
Query: 265 RRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LKVG 323
T+ L + DG LG I GG G+ + + PG A+ G L G
Sbjct: 254 HMETIEL------------VNDGSGLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCSG 299
Query: 324 DQILEVNGRSFLNILHDEAVRLLK 347
D IL++ + ++ ++L+
Sbjct: 300 DHILKIGDTDLAGMSSEQVAQVLR 323
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 17/206 (8%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALK 209
GLGF I GG G+ V + PG +A++ G L GD IL++ D LA ++ + + L+
Sbjct: 266 GLGFGIIGGK--ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 210 GSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQEGDRRSTL 269
V + + G I + + S P+ P+ A Q+G+ T
Sbjct: 324 QCGNRVKLMIARGAIEERTAPTALGITLS------SSPTSTPELRVDA-STQKGEESETF 376
Query: 270 HLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILE 328
D + V G G ++ I GI++ + S E G +++GDQI+
Sbjct: 377 ------DVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
Query: 329 VNGRSFLNILHDEAVRLLKSSRHLIL 354
V+G + + +AV +L+ + +L
Sbjct: 431 VDGTNLQGFTNQQAVEVLRHTGQTVL 456
Score = 51.2 bits (121), Expect = 4e-06
Identities = 39/141 (27%), Positives = 65/141 (46%), Gaps = 3/141 (2%)
Query: 749 TLSHLSDSGQTLSEDSGVDAGEAEASAPG-RGRQSVSTKSRSSKELPRNERPTDGANKPP 807
T+ + Q + +G +GE + S+ QS S + S + R+ P A+ P
Sbjct: 1559 TIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPA 1618
Query: 808 G--LLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVIL 865
++ T + + K LG++I GG++T I + G+A G+L G IL
Sbjct: 1619 TCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
Query: 866 EVNGLTLRGKEHREAARIIAE 886
EVNG+ LR H EA ++ +
Sbjct: 1679 EVNGIDLRKATHDEAINVLRQ 1699
Score = 49.3 bits (116), Expect = 2e-05
Identities = 50/228 (21%), Positives = 99/228 (43%), Gaps = 22/228 (9%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEHG-VGIYVSLVEPGSLAEKEG-LRVGDQILRVND 193
GE+ ++ L K H GLG S+ G + + +++ ++P A K+G L++ D++L +N
Sbjct: 1346 GELHMIELE--KGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 194 KSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDP---QGRSISPPSGL 250
+ L +H A +K + V ++ + + V+P ++
Sbjct: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
Query: 251 PQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSL-GLTIRGGAEYGLGIYITGV 309
P ++ HL D+ + + + + +L G+ I+ E+G+
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVA------ 1517
Query: 310 DPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVK 357
A LKVGDQIL V+ + ++ + LLK+++ +TVK
Sbjct: 1518 -----ATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAK---MTVK 1557
Score = 44.3 bits (103), Expect = 5e-04
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 9/103 (8%)
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSEH----GVGIYVSLVEPGSLAEKEG-LRVGDQILRV 191
E + + K +GLGFSI + I + + PG +AEK+G L GD+++ V
Sbjct: 695 EAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFV 754
Query: 192 NDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIP----GGYVT 230
ND +L + EAV+ALKG+ + + A +P GYV+
Sbjct: 755 NDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVS 797
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/77 (29%), Positives = 42/77 (54%)
Query: 808 GLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEV 867
G L ++ ++K + LG+++ G + + IV I G+A G+L++ +LE+
Sbjct: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEI 1401
Query: 868 NGLTLRGKEHREAARII 884
NG L G+ H+ A+ II
Sbjct: 1402 NGQILYGRSHQNASSII 1418
Score = 40.8 bits (94), Expect = 0.006
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 13/93 (13%)
Query: 258 LRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRS-LGLTIRGGAEYG-LGIYITGVDPGSEA 315
+R++ G LH+++ L G S LGL++ G + + ++I G+DP A
Sbjct: 1337 IRERYGTLTGELHMIE----------LEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAA 1386
Query: 316 EGSG-LKVGDQILEVNGRSFLNILHDEAVRLLK 347
G L++ D++LE+NG+ H A ++K
Sbjct: 1387 GKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Score = 37.7 bits (86), Expect = 0.049
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 812 PTSTLVRVKKSAATLGIAIEGG-ANTRQPLPRIV-TIQRGGSAHNCGQLKVGHVILEVNG 869
P + +++ LG +I GG + LP V T+ G+A G+LK G I+ VNG
Sbjct: 1954 PQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNG 2013
Query: 870 LTLRGKEHREAARII 884
+L G H EA I+
Sbjct: 2014 QSLEGVTHEEAVAIL 2028
Score = 37.0 bits (84), Expect = 0.083
Identities = 34/113 (30%), Positives = 57/113 (50%), Gaps = 7/113 (6%)
Query: 110 TAEGLYLPATTPYRQPAWGGPDSAGPGEV-RLVSLRRAKAHEGLGFSIRG--GSE--HGV 164
TA G+ L +++P P S GE + K +GLG +I G G +
Sbjct: 345 TALGITL-SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPS 403
Query: 165 GIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVL 216
GI+V + S E +G +++GDQI+ V+ +L T+ +AV+ L+ + + VL
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVL 456
Score = 34.7 bits (78), Expect = 0.41
Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 10/64 (15%)
Query: 826 LGIAIE---GGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAAR 882
LGI++E G R LP G + G+L G +LEVNG+TL G+ H++
Sbjct: 565 LGISLEATVGHHFIRSVLPE-------GPVGHSGKLFSGDELLEVNGITLLGENHQDVVN 617
Query: 883 IIAE 886
I+ E
Sbjct: 618 ILKE 621
Score = 32.7 bits (73), Expect = 1.6
Identities = 18/77 (23%), Positives = 40/77 (51%), Gaps = 3/77 (3%)
Query: 817 VRVKKSAATLGIAIEGGANTRQPLPR---IVTIQRGGSAHNCGQLKVGHVILEVNGLTLR 873
V + K+ LGI I G ++ P + +I + + + G++++G I+ V+G L+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 874 GKEHREAARIIAEAFKT 890
G +++A ++ +T
Sbjct: 438 GFTNQQAVEVLRHTGQT 454
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 65.5 bits (158), Expect = 2e-10
Identities = 70/232 (30%), Positives = 111/232 (47%), Gaps = 30/232 (12%)
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRV-GDQILRVNDKS 195
E+ V L++ KA GLG SI G +G G+++S + G A+ +G + GDQIL VN +
Sbjct: 1530 EIFPVDLQK-KAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGED 1587
Query: 196 LARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISP-----PSGL 250
+ + LK ++ LV GR+ G T+ T + QG S PS
Sbjct: 1588 MRNASQETVATILKCAQGLVQ--LEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFA 1645
Query: 251 PQPHG-----GALRQQEGDRRSTLHLLQGGDEK----KVNLVLGDGRSLGLTIRGGAEYG 301
P G G R + ++++ G D + ++N L D +LG++I GG
Sbjct: 1646 PVITGLQNLVGTKRVSDPSQKNS-----GTDMEPRTVEINRELSD--ALGISIAGGRGSP 1698
Query: 302 LG---IYITGVDP-GSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
LG ++I + G A LKVGD+I+ +NG+ + H + V LLK++
Sbjct: 1699 LGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 64.7 bits (156), Expect = 4e-10
Identities = 59/212 (27%), Positives = 99/212 (46%), Gaps = 32/212 (15%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALK 209
GLGF I GG GV V + PG LA+++G L+ GD IL++ ++ +T + + L+
Sbjct: 257 GLGFGIVGGKTSGV--VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 210 GSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISP--PSGLPQPHGGALRQQEGDRRS 267
V + R P G + S++P P+ LP + G S
Sbjct: 315 NCGNSVRML--VARDPAGDI-------------SVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 268 TLHLLQGGDEKKVNLVLGDGRSLGLTIRG--GAEY---GLGIYITGVDPGSEAEGSG-LK 321
+ V LV DG+SLG+ I G G + GIY+ + PGS A +G ++
Sbjct: 360 LF------ETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
Query: 322 VGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
V D+I+ V+G + + + V +L+++ ++
Sbjct: 414 VNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
Score = 62.8 bits (151), Expect = 1e-09
Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 55/264 (20%)
Query: 130 PDSAGPGEVRLVSLRRAKAHEGLGFSIRGGS---------EHGVGIYVSLVEPGSLAEK- 179
P+ + G R+V + R + + LG SI GG E GI++ V S A K
Sbjct: 1058 PNFSHWGPPRIVEIFR-EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKT 1116
Query: 180 EGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVY---------------SAGRI 224
L+ GD+IL V+ L +H+EAV+A+K + V+ + A +I
Sbjct: 1117 NALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKI 1176
Query: 225 PGGYVTNHIYTWVDPQGRSISPPSGLPQPHGG-----------------ALRQQEGDRRS 267
G + QG + PP LP P+ +RQ+ D
Sbjct: 1177 TGNQNQDTQEKKEKRQG-TAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPG 1235
Query: 268 TLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYG-LGIYITGVDPGSEAEGSG-LKVGDQ 325
LH+++ + D LGL++ G + + I++ G++P A G +++GD+
Sbjct: 1236 ELHIIE---------LEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 326 ILEVNGRSFLNILHDEAVRLLKSS 349
+LE+N + H A ++K++
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTA 1310
Score = 62.8 bits (151), Expect = 1e-09
Identities = 72/243 (29%), Positives = 102/243 (41%), Gaps = 58/243 (23%)
Query: 135 PGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYV--SLVEPGSLAEKEGLRVGDQILRVN 192
PG+ ++ + +K GLG SI GG + + V + E G+ A L GDQIL VN
Sbjct: 1432 PGQEMIIEI--SKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 193 DKSLARVTHAEAVKALKGS-KKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLP 251
L +H EA+ AL+ + +K+ L VY R Y D + I P
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQKVRLVVY---RDEAHY--------RDEENLEIFP----- 1533
Query: 252 QPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDP 311
V+L GR LGL+I G G G++I+ +
Sbjct: 1534 ----------------------------VDLQKKAGRGLGLSI-VGKRNGSGVFISDIVK 1564
Query: 312 GSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRL-----PHA 365
G A+ G L GDQIL VNG N + +LK ++ L+ ++GRL A
Sbjct: 1565 GGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQL--EIGRLRAGSWTSA 1622
Query: 366 RTT 368
RTT
Sbjct: 1623 RTT 1625
Score = 48.5 bits (114), Expect = 3e-05
Identities = 54/183 (29%), Positives = 83/183 (45%), Gaps = 35/183 (19%)
Query: 731 SEPDVNEVRALPQTRTASTLSHLSDSGQT----LSEDSGVDAG-----EAEA---SAPGR 778
+E VN++ P +S+ S + D T ED V+ G E+E+ +
Sbjct: 1321 NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQM 1380
Query: 779 GRQSVSTK-SRSSKELP----RNERPTD------GANKPPGLLEPTST--------LVRV 819
+Q TK S SS+E+P + TD G + P ++P + ++ +
Sbjct: 1381 KQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEI 1440
Query: 820 KKSAATLGIAIEGGANTRQPLPRIVT--IQRGGSAHNCGQLKVGHVILEVNGLTLRGKEH 877
K + LG++I GG +T PL IV + G+A G+L G ILEVNG+ LR H
Sbjct: 1441 SKGRSGLGLSIVGGKDT--PLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSH 1498
Query: 878 REA 880
EA
Sbjct: 1499 EEA 1501
Score = 48.1 bits (113), Expect = 4e-05
Identities = 53/207 (25%), Positives = 94/207 (45%), Gaps = 44/207 (21%)
Query: 151 GLGFSI---RGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILRVNDKSL-ARVTHAEAV 205
GLGFS+ R + V I+V V+PGS+A++ + L+ DQIL +N L ++H +A+
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 206 KALK---GSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQE 262
L+ GS +L+++ +P S S L
Sbjct: 204 ALLQQTTGSLRLIVA-------------------REPVHTKSSTSSSL------------ 232
Query: 263 GDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSG-LK 321
+ + + G ++V L+ DG LG I GG G+ + + PG A+ G L+
Sbjct: 233 -NDTTLPETVCWGHVEEVELI-NDGSGLGFGIVGGKT--SGVVVRTIVPGGLADRDGRLQ 288
Query: 322 VGDQILEVNGRSFLNILHDEAVRLLKS 348
GD IL++ G + + ++ ++L++
Sbjct: 289 TGDHILKIGGTNVQGMTSEQVAQVLRN 315
Score = 43.5 bits (101), Expect = 9e-04
Identities = 33/107 (30%), Positives = 53/107 (49%), Gaps = 10/107 (9%)
Query: 260 QQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGG---------AEYGLGIYITGVD 310
++EG+ T + G + V + SLG++I GG E GI+I V
Sbjct: 1049 REEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
Query: 311 PGSEA-EGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTV 356
S A + + LK GD+ILEV+G N H EAV +K++ + ++ +
Sbjct: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFI 1155
Score = 40.0 bits (92), Expect = 0.010
Identities = 40/138 (28%), Positives = 62/138 (44%), Gaps = 12/138 (8%)
Query: 756 SGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPRNERPTDGANKPPGL-LEPTS 814
S +T S++S A +S S + + L +R +D + K G +EP +
Sbjct: 1621 SARTTSQNSQGSQQSAHSSC----HPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRT 1676
Query: 815 TLVRVKKSAATLGIAIEGGANTRQPLPRI----VTIQRGGSAHNCGQLKVGHVILEVNGL 870
+ + S A LGI+I GG + PL I IQ G A +LKVG I+ +NG
Sbjct: 1677 VEINRELSDA-LGISIAGGRGS--PLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733
Query: 871 TLRGKEHREAARIIAEAF 888
L G H + ++ A+
Sbjct: 1734 PLDGLSHADVVNLLKNAY 1751
Score = 39.3 bits (90), Expect = 0.017
Identities = 20/72 (27%), Positives = 39/72 (54%)
Query: 816 LVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGK 875
++ ++K LG+++ G + + +V I G A G++++G +LE+N L G+
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 876 EHREAARIIAEA 887
H+ A+ II A
Sbjct: 1299 SHQNASAIIKTA 1310
Score = 37.0 bits (84), Expect = 0.083
Identities = 29/78 (37%), Positives = 40/78 (51%), Gaps = 7/78 (8%)
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSE-----HGVGIYVSLVEPGSLAEKEGLRVGDQILRV 191
EV++V L K +GLGFSI + V + SLV G GL GD+++ V
Sbjct: 683 EVKIVEL--VKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSV 740
Query: 192 NDKSLARVTHAEAVKALK 209
N+ L + AEAV+ LK
Sbjct: 741 NEYCLDNTSLAEAVEILK 758
Score = 33.5 bits (75), Expect = 0.92
Identities = 18/44 (40%), Positives = 23/44 (52%)
Query: 843 IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAE 886
I +I GG G L+ +LEVNG+ L GK REA + E
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE 626
Score = 32.0 bits (71), Expect = 2.7
Identities = 23/71 (32%), Positives = 30/71 (42%), Gaps = 8/71 (11%)
Query: 825 TLGIAIEGGANTRQPLPR--------IVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKE 876
+LGI+I GG + L I + A LK G ILEV+G+ L+
Sbjct: 1078 SLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 877 HREAARIIAEA 887
H EA I A
Sbjct: 1138 HSEAVEAIKNA 1148
Score = 31.6 bits (70), Expect = 3.5
Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Query: 820 KKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHRE 879
KK+ LG++I G N I I +GG+A G+L G IL VNG +R
Sbjct: 1538 KKAGRGLGLSIVGKRNGSGVF--ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQET 1595
Query: 880 AARII 884
A I+
Sbjct: 1596 VATIL 1600
>gi|9966877 golgi associated PDZ and coiled-coil motif containing
isoform a [Homo sapiens]
Length = 462
Score = 64.7 bits (156), Expect = 4e-10
Identities = 39/78 (50%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILR 190
S G G +R V L + + HEGLG SI GG EHGV I +S + PG A++ GL VGD IL
Sbjct: 280 SQGVGPIRKVLLLK-EDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILA 338
Query: 191 VNDKSLARVTHAEAVKAL 208
VN +L H EAV L
Sbjct: 339 VNGVNLRDTKHKEAVTIL 356
Score = 58.5 bits (140), Expect = 3e-08
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 2/90 (2%)
Query: 263 GDRRSTLHLLQG-GDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEG-SGL 320
G + +L QG G +KV L+ D LG++I GG E+G+ I I+ + PG A+ GL
Sbjct: 271 GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGL 330
Query: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSR 350
VGD IL VNG + + H EAV +L R
Sbjct: 331 HVGDAILAVNGVNLRDTKHKEAVTILSQQR 360
Score = 50.1 bits (118), Expect = 1e-05
Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 801 DGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKV 860
D K G+ P ++ +K+ LGI+I GG P+ I I G A CG L V
Sbjct: 275 DSLKKSQGV-GPIRKVLLLKEDHEGLGISITGGKEHGVPI-LISEIHPGQPADRCGGLHV 332
Query: 861 GHVILEVNGLTLRGKEHREAARIIAE 886
G IL VNG+ LR +H+EA I+++
Sbjct: 333 GDAILAVNGVNLRDTKHKEAVTILSQ 358
>gi|62868213 golgi associated PDZ and coiled-coil motif containing
isoform b [Homo sapiens]
Length = 454
Score = 64.7 bits (156), Expect = 4e-10
Identities = 39/78 (50%), Positives = 47/78 (60%), Gaps = 2/78 (2%)
Query: 132 SAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK-EGLRVGDQILR 190
S G G +R V L + + HEGLG SI GG EHGV I +S + PG A++ GL VGD IL
Sbjct: 272 SQGVGPIRKVLLLK-EDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILA 330
Query: 191 VNDKSLARVTHAEAVKAL 208
VN +L H EAV L
Sbjct: 331 VNGVNLRDTKHKEAVTIL 348
Score = 58.5 bits (140), Expect = 3e-08
Identities = 37/90 (41%), Positives = 51/90 (56%), Gaps = 2/90 (2%)
Query: 263 GDRRSTLHLLQG-GDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEG-SGL 320
G + +L QG G +KV L+ D LG++I GG E+G+ I I+ + PG A+ GL
Sbjct: 263 GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGL 322
Query: 321 KVGDQILEVNGRSFLNILHDEAVRLLKSSR 350
VGD IL VNG + + H EAV +L R
Sbjct: 323 HVGDAILAVNGVNLRDTKHKEAVTILSQQR 352
Score = 50.1 bits (118), Expect = 1e-05
Identities = 32/86 (37%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 801 DGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKV 860
D K G+ P ++ +K+ LGI+I GG P+ I I G A CG L V
Sbjct: 267 DSLKKSQGV-GPIRKVLLLKEDHEGLGISITGGKEHGVPI-LISEIHPGQPADRCGGLHV 324
Query: 861 GHVILEVNGLTLRGKEHREAARIIAE 886
G IL VNG+ LR +H+EA I+++
Sbjct: 325 GDAILAVNGVNLRDTKHKEAVTILSQ 350
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 64.3 bits (155), Expect = 5e-10
Identities = 58/209 (27%), Positives = 89/209 (42%), Gaps = 43/209 (20%)
Query: 55 REQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGL 114
+EQ L + A + V DLV TL + L LL LR+ IP+ + FD+ ++GL
Sbjct: 155 KEQVFAALKQFAAEQRVDDLVWTLTLALPREACGPLLDNLRIFIPKKHRARFDEVVSQGL 214
Query: 115 Y------------------------------LPATTPYRQPAWGGPDSA--------GPG 136
A+ P R+P P A GPG
Sbjct: 215 LGKLCRARRAQGAQRLRRSRSEERPERLLVSTRASAPPRRPDEPPPRRASLLVGGLAGPG 274
Query: 137 EVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSL 196
R ++R K ++ GF++RG HG +++ V PGS A+ L+ GD+IL +N +
Sbjct: 275 GARR-TVRVYKGNKSFGFTLRG---HGP-VWIESVLPGSPADNAALKSGDRILFLNGLDM 329
Query: 197 ARVTHAEAVKALKGSKKLVLSVYSAGRIP 225
+H + V L+GS + V G +P
Sbjct: 330 RNCSHDKVVSMLQGSGAMPTLVVEEGLVP 358
Score = 60.1 bits (144), Expect = 9e-09
Identities = 98/430 (22%), Positives = 155/430 (36%), Gaps = 74/430 (17%)
Query: 274 GGDEKKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRS 333
GG + V + G+ +S G T+RG ++I V PGS A+ + LK GD+IL +NG
Sbjct: 274 GGARRTVRVYKGN-KSFGFTLRGHGP----VWIESVLPGSPADNAALKSGDRILFLNGLD 328
Query: 334 FLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTVDETKWIASSRIRETMANSAGFLGD 393
N HD+ V +L+ S + V + G +P A
Sbjct: 329 MRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFAS--------------------------- 361
Query: 394 LTTEGINKPGFYKGPAGSQVTLSSLGNQTRV---LLEEQARHLLNEQEHATMAYYLDEYR 450
++ ++ P Q L + RV +Q HLL E + L+ +
Sbjct: 362 -DSDSLDSPNPSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFF 420
Query: 451 GGSVSVEALVMALFKLLNTHAK-------FSLLSEVRGTISPQDLERF-DHLVLRREIE- 501
+++ L++ ++ +L+T AK + LL+ + + + F + + E E
Sbjct: 421 QHR-NIDTLIVDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAEPEP 479
Query: 502 SMKARQPPGPGAGDTYSMVSYSDTGSSTGSHGTSTTVSSARNTLDLEE----TGEAVQGN 557
+ P P S+ + S S S G +S + GE G+
Sbjct: 480 ELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGERQAGD 539
Query: 558 INALPDVSVDDVRST------SQGLSSFK-----------PLPRPPPLAQGNDLPLGQPR 600
+LP+ + S S+ SSFK P P P L
Sbjct: 540 GTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTGPRTLSGVS 599
Query: 601 KLGREDLQPPSSMPSCSGTVFSAPQNRSPP-----AGTAPTPGTSSAQDLPSSPIYASVS 655
L P P CSG + S + S P + AP+P P SP S
Sbjct: 600 WPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSRAPSPQPGPGPICPDSP--PSPD 657
Query: 656 PANPSSKRPL 665
P P S+R L
Sbjct: 658 PTRPPSRRKL 667
Score = 35.4 bits (80), Expect = 0.24
Identities = 53/203 (26%), Positives = 77/203 (37%), Gaps = 32/203 (15%)
Query: 305 YITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSSRHL-----ILTVKD- 358
++ V GS A GL+ GDQILEV G + + + VRL + + +L D
Sbjct: 28 FVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPRVPPSLGVLPAPDG 87
Query: 359 ---VGRLPHARTTVDETKWIASSRIRETMANSAGFL---GDLTTEGINKPGFYKGPAGSQ 412
G P A TTV + + R +A L G + +++ K S+
Sbjct: 88 GPGPGSGPAAPTTV-----LRAPRCGRGLALGRELLRLAGRKRPDAVHRERRRKAQEFSR 142
Query: 413 VTLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAK 472
LG+Q EQ A + + E R V+ LV L L A
Sbjct: 143 KVDEILGDQPTA----------KEQVFAALKQFAAEQR-----VDDLVWTLTLALPREAC 187
Query: 473 FSLLSEVRGTISPQDLERFDHLV 495
LL +R I + RFD +V
Sbjct: 188 GPLLDNLRIFIPKKHRARFDEVV 210
Score = 32.0 bits (71), Expect = 2.7
Identities = 45/190 (23%), Positives = 77/190 (40%), Gaps = 11/190 (5%)
Query: 40 RQLHQALTALLSEAEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIP 99
R Q L LL+ ER L ++ RN+ L+ + +LD+P K+ L + ++
Sbjct: 394 RTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQFIYQLLT 453
Query: 100 RSDQLLFDQYTAEGLYLPATTPYRQP-----AWGGPDSAGPGEVRLVSL-RRAKAHEGLG 153
+Q L + A L A T +P + P+ +R S+ RR+ +GL
Sbjct: 454 YEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSMCRRSLRSQGLE 513
Query: 154 FSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKK 213
+ G + + L+ PG +G + + N K ++ V +AE L S K
Sbjct: 514 AGLSCGPSECPEMPLPLI-PGERQAGDGTSLPE---TPNPKMMSAV-YAELESRLNSSFK 568
Query: 214 LVLSVYSAGR 223
+ S R
Sbjct: 569 GKMGTVSKSR 578
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 64.3 bits (155), Expect = 5e-10
Identities = 61/231 (26%), Positives = 102/231 (44%), Gaps = 27/231 (11%)
Query: 131 DSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQIL 189
++ G G V + S+ R +A + H +G + GS A++ G L+VGD+IL
Sbjct: 1005 ENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIE----GSPADRCGKLKVGDRIL 1060
Query: 190 RVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNH-----------IYTWVD 238
VN S+ +H++ V +K + V + IPG +N I T
Sbjct: 1061 AVNGCSITNKSHSDIVNLIKEAGNTV----TLRIIPGDESSNATLLTNAEKIATITTTHT 1116
Query: 239 PQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGA 298
P + +P +Q+ Q D V L G + G ++RGG
Sbjct: 1117 PSQQGTQETRNTTKP-----KQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRGGR 1170
Query: 299 EYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKS 348
EY + +Y+ + AE G +++GD+ILE+NG + N+ H A+ L+K+
Sbjct: 1171 EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1221
Score = 55.8 bits (133), Expect = 2e-07
Identities = 61/241 (25%), Positives = 98/241 (40%), Gaps = 42/241 (17%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALK 209
G GF I GG+E G IY+ + P A+ +G LR GD+++ V+ + +H V+ ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 210 GS-----------KKLVLSV-YSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGA 257
+ +K+V +V + +P ++H Q S++ PQ +
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHH----SSNQPASLTEEKRTPQGSQNS 965
Query: 258 LRQQEGDRRSTLHLLQGG-----------DEKKVNLVLGDGRSLGL-------------T 293
L ST + GG V + G+ G T
Sbjct: 966 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 1025
Query: 294 IRGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHL 352
G A + I + GS A+ G LKVGD+IL VNG S N H + V L+K + +
Sbjct: 1026 FAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1085
Query: 353 I 353
+
Sbjct: 1086 V 1086
Score = 50.1 bits (118), Expect = 1e-05
Identities = 23/67 (34%), Positives = 42/67 (62%), Gaps = 1/67 (1%)
Query: 150 EGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKAL 208
+G GFS+RGG E+ + +YV + AE+ G +R+GD+IL +N ++ + H+ A++ +
Sbjct: 1160 KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1219
Query: 209 KGSKKLV 215
K + V
Sbjct: 1220 KNGGRRV 1226
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/164 (29%), Positives = 65/164 (39%), Gaps = 22/164 (13%)
Query: 727 HRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTK 786
H + + E + PQ S + S SG T SG+ +G G G VST
Sbjct: 944 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST----SGIGSGG------GGGSGVVSTV 993
Query: 787 SRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTI 846
+ P + G N+ G + +S S G G A P +I I
Sbjct: 994 VQ-----PYDVEIRRGENEGFGFVIVSSV------SRPEAGTTFAGNACVAMP-HKIGRI 1041
Query: 847 QRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKT 890
G A CG+LKVG IL VNG ++ K H + +I EA T
Sbjct: 1042 IEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1085
Score = 43.9 bits (102), Expect = 7e-04
Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVIL 865
P E V +++ A G ++ GG L ++ + G A CG++++G IL
Sbjct: 1142 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEIL 1200
Query: 866 EVNGLTLRGKEHREAARII 884
E+NG T + +H A +I
Sbjct: 1201 EINGETTKNMKHSRAIELI 1219
Score = 38.5 bits (88), Expect = 0.029
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYV-SLVEPGSLAEKEGLRVGDQILRVNDKSLA 197
+ + + K+ G GF++ GG E + + SLV G A + GD I+ VND +
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 198 RVTHAEAVK 206
THA+ VK
Sbjct: 529 GHTHAQVVK 537
Score = 31.6 bits (70), Expect = 3.5
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 7/81 (8%)
Query: 140 LVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARV 199
L+++ K G GF+I S G G V + GL+ GD I+ VN K++ +
Sbjct: 641 LITVHIVKGPMGFGFTI-ADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQAL 697
Query: 200 THAEAVKAL----KGSKKLVL 216
TH + V L KGS+ +L
Sbjct: 698 THNQVVDMLVECPKGSEVTLL 718
Score = 31.2 bits (69), Expect = 4.6
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 285 GDGRSLGLTIRGGAEYGLGIYITGVD-------PGSEAEGSGLKVGDQILEVNGRSFLNI 337
G LG+T+ GGAE+G Y+ V PG EG L G+ +LEV G +
Sbjct: 23 GPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG-GEGPRLGEGELLLEVQGVRVSGL 81
Query: 338 LHDEAVRLLKSSRHLIL--TVKDVGRL 362
+ + ++ S + + V+ GRL
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRL 108
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 64.3 bits (155), Expect = 5e-10
Identities = 63/233 (27%), Positives = 102/233 (43%), Gaps = 36/233 (15%)
Query: 141 VSLRRAKAHEGLGFSI-------RGGSEHGVGIY-----VSLVEPGSLAEKEG-LRVGDQ 187
V +RR + +EG GF I G+ G + + GS A++ G L+VGD+
Sbjct: 971 VEIRRGE-NEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
Query: 188 ILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNH-----------IYTW 236
IL VN S+ +H++ V +K + V + IPG +N I T
Sbjct: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTV----TLRIIPGDESSNATLLTNAEKIATITTT 1085
Query: 237 VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRG 296
P + +P +Q+ Q D V L G + G ++RG
Sbjct: 1086 HTPSQQGTQETRNTTKP-----KQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRG 1139
Query: 297 GAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKS 348
G EY + +Y+ + AE G +++GD+ILE+NG + N+ H A+ L+K+
Sbjct: 1140 GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
Score = 55.5 bits (132), Expect = 2e-07
Identities = 61/240 (25%), Positives = 98/240 (40%), Gaps = 41/240 (17%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALK 209
G GF I GG+E G IY+ + P A+ +G LR GD+++ V+ + +H V+ ++
Sbjct: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 881
Query: 210 GS-----------KKLVLSV-YSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGA 257
+ +K+V +V + +P ++H Q S++ PQ +
Sbjct: 882 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN----QPASLTEEKRTPQGSQNS 937
Query: 258 LRQQEGDRRSTLHLLQGG-----------DEKKVNLVLGDGRSLGLTI-------RGGAE 299
L ST + GG V + G+ G I G
Sbjct: 938 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 997
Query: 300 YGLGIY-----ITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
+G I + GS A+ G LKVGD+IL VNG S N H + V L+K + + +
Sbjct: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
Score = 54.7 bits (130), Expect = 4e-07
Identities = 40/140 (28%), Positives = 66/140 (47%), Gaps = 16/140 (11%)
Query: 150 EGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKAL 208
+G GFS+RGG E+ + +YV + AE+ G +R+GD+IL +N ++ + H+ A++ +
Sbjct: 1131 KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1190
Query: 209 KGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISP---PSGLPQPHGGALRQQEGDR 265
K + V G G V + DP P P G+P+ G R+Q
Sbjct: 1191 KNGGRRVRLFLKRG---DGSVPEY-----DPSSDRHGPATGPQGVPEVRAGPDRRQHPSL 1242
Query: 266 RST----LHLLQGGDEKKVN 281
S+ LH EK+ +
Sbjct: 1243 ESSYPPDLHKSSPHGEKRAH 1262
Score = 43.9 bits (102), Expect = 7e-04
Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVIL 865
P E V +++ A G ++ GG L ++ + G A CG++++G IL
Sbjct: 1113 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEIL 1171
Query: 866 EVNGLTLRGKEHREAARII 884
E+NG T + +H A +I
Sbjct: 1172 EINGETTKNMKHSRAIELI 1190
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/165 (29%), Positives = 68/165 (41%), Gaps = 25/165 (15%)
Query: 727 HRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTK 786
H + + E + PQ S + S SG T SG+ +G G G VST
Sbjct: 916 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST----SGIGSGG------GGGSGVVSTV 965
Query: 787 SRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLP-RIVT 845
+ P + G N+ G + +S V ++ T G N +P +I
Sbjct: 966 VQ-----PYDVEIRRGENEGFGFVIVSS--VSRPEAGTTFG-------NACVAMPHKIGR 1011
Query: 846 IQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKT 890
I G A CG+LKVG IL VNG ++ K H + +I EA T
Sbjct: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056
Score = 38.5 bits (88), Expect = 0.029
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYV-SLVEPGSLAEKEGLRVGDQILRVNDKSLA 197
+ + + K+ G GF++ GG E + + SLV G A + GD I+ VND +
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 198 RVTHAEAVK 206
THA+ VK
Sbjct: 529 GHTHAQVVK 537
Score = 31.6 bits (70), Expect = 3.5
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 7/81 (8%)
Query: 140 LVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARV 199
L+++ K G GF+I S G G V + GL+ GD I+ VN K++ +
Sbjct: 641 LITVHIVKGPMGFGFTI-ADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQAL 697
Query: 200 THAEAVKAL----KGSKKLVL 216
TH + V L KGS+ +L
Sbjct: 698 THNQVVDMLVECPKGSEVTLL 718
Score = 31.2 bits (69), Expect = 4.6
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 285 GDGRSLGLTIRGGAEYGLGIYITGVD-------PGSEAEGSGLKVGDQILEVNGRSFLNI 337
G LG+T+ GGAE+G Y+ V PG EG L G+ +LEV G +
Sbjct: 23 GPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG-GEGPRLGEGELLLEVQGVRVSGL 81
Query: 338 LHDEAVRLLKSSRHLIL--TVKDVGRL 362
+ + ++ S + + V+ GRL
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRL 108
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 64.3 bits (155), Expect = 5e-10
Identities = 63/233 (27%), Positives = 102/233 (43%), Gaps = 36/233 (15%)
Query: 141 VSLRRAKAHEGLGFSI-------RGGSEHGVGIY-----VSLVEPGSLAEKEG-LRVGDQ 187
V +RR + +EG GF I G+ G + + GS A++ G L+VGD+
Sbjct: 999 VEIRRGE-NEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
Query: 188 ILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNH-----------IYTW 236
IL VN S+ +H++ V +K + V + IPG +N I T
Sbjct: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTV----TLRIIPGDESSNATLLTNAEKIATITTT 1113
Query: 237 VDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRG 296
P + +P +Q+ Q D V L G + G ++RG
Sbjct: 1114 HTPSQQGTQETRNTTKP-----KQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRG 1167
Query: 297 GAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKS 348
G EY + +Y+ + AE G +++GD+ILE+NG + N+ H A+ L+K+
Sbjct: 1168 GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
Score = 55.5 bits (132), Expect = 2e-07
Identities = 61/240 (25%), Positives = 98/240 (40%), Gaps = 41/240 (17%)
Query: 151 GLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALK 209
G GF I GG+E G IY+ + P A+ +G LR GD+++ V+ + +H V+ ++
Sbjct: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
Query: 210 GS-----------KKLVLSV-YSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGA 257
+ +K+V +V + +P ++H Q S++ PQ +
Sbjct: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN----QPASLTEEKRTPQGSQNS 965
Query: 258 LRQQEGDRRSTLHLLQGG-----------DEKKVNLVLGDGRSLGLTI-------RGGAE 299
L ST + GG V + G+ G I G
Sbjct: 966 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 1025
Query: 300 YGLGIY-----ITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLKSSRHLI 353
+G I + GS A+ G LKVGD+IL VNG S N H + V L+K + + +
Sbjct: 1026 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
Score = 50.1 bits (118), Expect = 1e-05
Identities = 23/67 (34%), Positives = 42/67 (62%), Gaps = 1/67 (1%)
Query: 150 EGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKAL 208
+G GFS+RGG E+ + +YV + AE+ G +R+GD+IL +N ++ + H+ A++ +
Sbjct: 1159 KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
Query: 209 KGSKKLV 215
K + V
Sbjct: 1219 KNGGRRV 1225
Score = 43.9 bits (102), Expect = 7e-04
Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 806 PPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHVIL 865
P E V +++ A G ++ GG L ++ + G A CG++++G IL
Sbjct: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEIL 1199
Query: 866 EVNGLTLRGKEHREAARII 884
E+NG T + +H A +I
Sbjct: 1200 EINGETTKNMKHSRAIELI 1218
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/165 (29%), Positives = 68/165 (41%), Gaps = 25/165 (15%)
Query: 727 HRPDSEPDVNEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTK 786
H + + E + PQ S + S SG T SG+ +G G G VST
Sbjct: 944 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST----SGIGSGG------GGGSGVVSTV 993
Query: 787 SRSSKELPRNERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLP-RIVT 845
+ P + G N+ G + +S V ++ T G N +P +I
Sbjct: 994 VQ-----PYDVEIRRGENEGFGFVIVSS--VSRPEAGTTFG-------NACVAMPHKIGR 1039
Query: 846 IQRGGSAHNCGQLKVGHVILEVNGLTLRGKEHREAARIIAEAFKT 890
I G A CG+LKVG IL VNG ++ K H + +I EA T
Sbjct: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
Score = 38.5 bits (88), Expect = 0.029
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYV-SLVEPGSLAEKEGLRVGDQILRVNDKSLA 197
+ + + K+ G GF++ GG E + + SLV G A + GD I+ VND +
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
Query: 198 RVTHAEAVK 206
THA+ VK
Sbjct: 529 GHTHAQVVK 537
Score = 31.6 bits (70), Expect = 3.5
Identities = 26/81 (32%), Positives = 39/81 (48%), Gaps = 7/81 (8%)
Query: 140 LVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARV 199
L+++ K G GF+I S G G V + GL+ GD I+ VN K++ +
Sbjct: 641 LITVHIVKGPMGFGFTI-ADSPGGGGQRVKQIVDSPRCR--GLKEGDLIVEVNKKNVQAL 697
Query: 200 THAEAVKAL----KGSKKLVL 216
TH + V L KGS+ +L
Sbjct: 698 THNQVVDMLVECPKGSEVTLL 718
Score = 31.2 bits (69), Expect = 4.6
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 285 GDGRSLGLTIRGGAEYGLGIYITGVD-------PGSEAEGSGLKVGDQILEVNGRSFLNI 337
G LG+T+ GGAE+G Y+ V PG EG L G+ +LEV G +
Sbjct: 23 GPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGG-GEGPRLGEGELLLEVQGVRVSGL 81
Query: 338 LHDEAVRLLKSSRHLIL--TVKDVGRL 362
+ + ++ S + + V+ GRL
Sbjct: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRL 108
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 63.5 bits (153), Expect = 8e-10
Identities = 33/80 (41%), Positives = 49/80 (61%)
Query: 278 KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNI 337
+ + L G LG IRGG LGI+I+ V P S+A +GL+ GDQ+L VN F +I
Sbjct: 46 RTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDI 105
Query: 338 LHDEAVRLLKSSRHLILTVK 357
H +AV +LK++R + + V+
Sbjct: 106 EHSKAVEILKTAREISMRVR 125
Score = 60.8 bits (146), Expect = 5e-09
Identities = 31/80 (38%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 139 RLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLAR 198
R ++L++ + LGF+IRGG +GI++S V P S A + GL+ GDQ+L VND
Sbjct: 46 RTITLKKPPGAQ-LGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQD 104
Query: 199 VTHAEAVKALKGSKKLVLSV 218
+ H++AV+ LK ++++ + V
Sbjct: 105 IEHSKAVEILKTAREISMRV 124
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 62.8 bits (151), Expect = 1e-09
Identities = 71/241 (29%), Positives = 106/241 (43%), Gaps = 29/241 (12%)
Query: 130 PDSAGPGEVRL-VSLRRAKAHEGLGFS-IRGGSEHGVGIYVSLVEPGSLAEKEG-LRVGD 186
PD+ P + V L ++ E LG +R E GV I+ L G +A + G L D
Sbjct: 370 PDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVL--DGGVAYRHGQLEEND 427
Query: 187 QILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISP 246
++L +N L + A ++ S++ V V S V + I
Sbjct: 428 RVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ--------------VRQRSPDIFQ 473
Query: 247 PSGLPQPHGGALRQQEGDRRST---LHLLQGGDEKKVNLVLGDGRSLGLTIRGGA---EY 300
+G G+ G+R +T LH EK VN+ G SLG+T+ GGA E+
Sbjct: 474 EAGWNS--NGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREW 531
Query: 301 GLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLLK-SSRHLILTVKD 358
L IY+ V+PG G +K GD +L V+G + EAV LLK +S ++L +
Sbjct: 532 DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALE 591
Query: 359 V 359
V
Sbjct: 592 V 592
Score = 58.5 bits (140), Expect = 3e-08
Identities = 74/266 (27%), Positives = 114/266 (42%), Gaps = 48/266 (18%)
Query: 122 YRQPAWG--GPDSAGPGE---------------VRLVSLRRAKAHEGLGFSIRGGSEH-- 162
+++ W G S GPGE ++V++++ E LG ++ GG+ H
Sbjct: 472 FQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGMTVAGGASHRE 530
Query: 163 -GVGIYVSLVEPGSLAEKEG-LRVGDQILRVNDKSLARVTHAEAVKALKG-SKKLVLSVY 219
+ IYV VEPG + ++G ++ GD +L V+ L V+ +EAV LK S +VL
Sbjct: 531 WDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 590
Query: 220 SAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGG---- 275
+PQ S P+ L H A S + L+
Sbjct: 591 EVKEY-------------EPQ-EDCSSPAALDSNHNMAPPSDWSP--SWVMWLELPRCLY 634
Query: 276 DEKKVNLVLGDGRSLGLTIRGGAEYGLG---IYITGVDPGSEAEGSG-LKVGDQILEVNG 331
+ K + L SLG I GG E G +I + G+ A G ++ GD +L VNG
Sbjct: 635 NCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG 694
Query: 332 RSFLNILHDEAVRLLKSSR-HLILTV 356
RS ++H RLLK + + LT+
Sbjct: 695 RSTSGMIHACLARLLKELKGRITLTI 720
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/153 (27%), Positives = 66/153 (43%), Gaps = 12/153 (7%)
Query: 736 NEVRALPQTRTASTLSHLSDSGQTLSEDSGVDAGEAEASAPGRGRQSVSTKSRSSKELPR 795
N RA P R+ + LS +G A A+ +GR++ S + + + PR
Sbjct: 204 NRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGREN-SENTTAPEVFPR 262
Query: 796 NERPTDGANKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVT--IQRGGSAH 853
P G E TS + + +L I + GG+ T PL I+ I R G
Sbjct: 263 LYHLI-----PDG--EITSIKINRVDPSESLSIRLVGGSET--PLVHIIIQHIYRDGVIA 313
Query: 854 NCGQLKVGHVILEVNGLTLRGKEHREAARIIAE 886
G+L G +IL+VNG+ + H A R++ +
Sbjct: 314 RDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQ 346
Score = 40.0 bits (92), Expect = 0.010
Identities = 28/93 (30%), Positives = 51/93 (54%), Gaps = 8/93 (8%)
Query: 799 PTDGANKPPGLLEPTST----LVRVKKSAA-TLGIAIEGGANTRQ-PLP-RIVTIQRGGS 851
P + +N P L PT T +V ++K +LG+ + GGA+ R+ LP +++++ GG
Sbjct: 487 PGERSNTPKPL-HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGV 545
Query: 852 AHNCGQLKVGHVILEVNGLTLRGKEHREAARII 884
G++K G ++L V+G+ L EA ++
Sbjct: 546 ISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
Score = 39.3 bits (90), Expect = 0.017
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 4/83 (4%)
Query: 807 PGLLEPTSTLVRVKKSAATLGIAIEGGA---NTRQPLPRIVTIQRGGSAHNCGQLKVGHV 863
P L +V + +A +LG I GG N +P I +I G A+N G+++ G +
Sbjct: 630 PRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPF-FIKSIVEGTPAYNDGRIRCGDI 688
Query: 864 ILEVNGLTLRGKEHREAARIIAE 886
+L VNG + G H AR++ E
Sbjct: 689 LLAVNGRSTSGMIHACLARLLKE 711
Score = 37.0 bits (84), Expect = 0.083
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 136 GEVRLVSLRRAKAHEGLGFSIRGGSEHGVG--IYVSLVEPGSLAEKEGLRVGDQILRVND 193
GE+ + + R E L + GGSE + I + G +A L GD IL+VN
Sbjct: 270 GEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNG 329
Query: 194 KSLARVTHAEAVKALK 209
++ V H AV+ L+
Sbjct: 330 MDISNVPHNYAVRLLR 345
Score = 35.8 bits (81), Expect = 0.19
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 11/85 (12%)
Query: 270 HLLQGGDEKKVNLVLGD-GRSLGLTIRGGAEYGL------GIYITGVDPGSEAEGSGLKV 322
HL+ G+ + + D SL + + GG+E L IY GV A L
Sbjct: 265 HLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVI----ARDGRLLP 320
Query: 323 GDQILEVNGRSFLNILHDEAVRLLK 347
GD IL+VNG N+ H+ AVRLL+
Sbjct: 321 GDIILKVNGMDISNVPHNYAVRLLR 345
Score = 35.0 bits (79), Expect = 0.32
Identities = 29/85 (34%), Positives = 45/85 (52%), Gaps = 6/85 (7%)
Query: 141 VSLRRAKAHEGLGFSIRGGSEHGVG---IYVSLVEPGSLAEKEG-LRVGDQILRVNDKSL 196
+ LRR A LGF I GG E G ++ + G+ A +G +R GD +L VN +S
Sbjct: 639 IVLRRNTAGS-LGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697
Query: 197 ARVTHAEAVKALKGSK-KLVLSVYS 220
+ + HA + LK K ++ L++ S
Sbjct: 698 SGMIHACLARLLKELKGRITLTIVS 722
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,460,482
Number of Sequences: 37866
Number of extensions: 2083772
Number of successful extensions: 13119
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 539
Number of HSP's that attempted gapping in prelim test: 10537
Number of HSP's gapped (non-prelim): 2804
length of query: 907
length of database: 18,247,518
effective HSP length: 111
effective length of query: 796
effective length of database: 14,044,392
effective search space: 11179336032
effective search space used: 11179336032
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.