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Search of human proteins with 7657395
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657395 photoreceptor-specific nuclear receptor isoform b
[Homo sapiens]
(410 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 828 0.0
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 744 0.0
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 304 1e-82
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 276 2e-74
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 276 3e-74
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 273 2e-73
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 221 1e-57
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 219 3e-57
gi|11415052 retinoid X receptor, beta [Homo sapiens] 216 2e-56
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 186 3e-47
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 184 1e-46
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 184 1e-46
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 184 1e-46
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 184 1e-46
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 184 1e-46
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 184 1e-46
gi|223555953 nuclear receptor subfamily 2, group F, member 2 iso... 177 2e-44
gi|223555951 nuclear receptor subfamily 2, group F, member 2 iso... 177 2e-44
gi|223555949 nuclear receptor subfamily 2, group F, member 2 iso... 177 2e-44
gi|238550159 estrogen-related receptor beta [Homo sapiens] 162 7e-40
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 155 5e-38
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 155 5e-38
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 155 5e-38
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 155 5e-38
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 150 2e-36
gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens] 147 1e-35
gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens] 147 1e-35
gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens] 147 1e-35
gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens] 147 1e-35
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 138 1e-32
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 828 bits (2139), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG 60
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG
Sbjct: 1 METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG 60
Query: 61 IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN 120
IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN
Sbjct: 61 IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN 120
Query: 121 ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 180
ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA
Sbjct: 121 ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 180
Query: 181 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV 240
ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV
Sbjct: 181 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV 240
Query: 241 FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET 300
FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET
Sbjct: 241 FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET 300
Query: 301 RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH 360
RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH
Sbjct: 301 RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH 360
Query: 361 HPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN 410
HPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
Sbjct: 361 HPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN 410
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 744 bits (1921), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG 60
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG
Sbjct: 1 METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYG 60
Query: 61 IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN 120
IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN
Sbjct: 61 IYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQN 120
Query: 121 ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 180
ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA
Sbjct: 121 ERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITA 180
Query: 181 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV 240
ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV
Sbjct: 181 ETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPV 240
Query: 241 FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET 300
FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET
Sbjct: 241 FSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMET 300
Query: 301 RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH 360
RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH
Sbjct: 301 RVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAH 360
Query: 361 HPSQPVR 367
HPSQPVR
Sbjct: 361 HPSQPVR 367
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 304 bits (778), Expect = 1e-82
Identities = 164/377 (43%), Positives = 231/377 (61%), Gaps = 19/377 (5%)
Query: 45 LQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVG-AGMCPVDKAHRNQCQAC 103
+ C+VCGD SSGKHYG+YAC+GCSGFFKRS+RR Y C+ G G CPVDK HRNQC+AC
Sbjct: 14 IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRAC 73
Query: 104 RLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPM 163
RLKKCL+ MN+DAVQ+ER PR T+ + + E+ A P+ P P
Sbjct: 74 RLKKCLEVNMNKDAVQHERGPR-TSTIRKQVALYFRGHKEENGAAAHFPSAALP-APAFF 131
Query: 164 SAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSS---PCGLDSI 220
+A L H + E A + + + P++P + +S+
Sbjct: 132 TAVTQLEPHGL------ELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESV 185
Query: 221 HETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAP 280
E++ARLLFM++KWAK++P FS+L +DQ++LLE+AW ELF+LG QW++P+D+ LLA
Sbjct: 186 CESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAV 245
Query: 281 PEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFK-------PET 333
+ +L E + LQE ++RFR L +D TEFAC+K +V FK E
Sbjct: 246 SGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSEL 305
Query: 334 RGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRK 393
R ++ + ALQD++Q+ L+ + +P+QP RFGKLLLLLP+LR I+ IE +FF+K
Sbjct: 306 RSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKK 365
Query: 394 TIGNTPMEKLLCDMFKN 410
TIGN P+ +LL DM+K+
Sbjct: 366 TIGNVPITRLLSDMYKS 382
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 276 bits (707), Expect = 2e-74
Identities = 163/399 (40%), Positives = 212/399 (53%), Gaps = 35/399 (8%)
Query: 14 AAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQ--CRVCGDSSSGKHYGIYACNGCSGFF 71
A P A PG E P LQ C VCGD SSGKHYG++ C GC FF
Sbjct: 21 AGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGVFTCEGCKSFF 80
Query: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
KRS+RR L Y C+ C +D+ HRNQCQ CRLKKC + GM ++AVQ R P S
Sbjct: 81 KRSIRRNLSYTCRSNRD-CQIDQHHRNQCQYCRLKKCFRVGMRKEAVQRGRIPHSL---- 135
Query: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKL---EP 188
P A A S P AA A G +E A+L EP
Sbjct: 136 -----------------PGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEP 178
Query: 189 EDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRD 248
A F + ++ + G+D++ E +ARLLF V+WA++ P F LP D
Sbjct: 179 YPAAAG--------RFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVAD 230
Query: 249 QVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETIS 308
QV LL +WSELF+L A Q +LPL + PLLA AA A R + R QE +
Sbjct: 231 QVALLRLSWSELFVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVD 290
Query: 309 RFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRF 368
+ L VD E+ C+KA+ LF P+ GL DP HVE+LQ+++QV L+++ +A +PSQP RF
Sbjct: 291 KLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRF 350
Query: 369 GKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
G+LLL LP+LR + A I LFF + +G TP+E L+ DM
Sbjct: 351 GRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDM 389
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 276 bits (705), Expect = 3e-74
Identities = 158/393 (40%), Positives = 218/393 (55%), Gaps = 42/393 (10%)
Query: 15 AAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRS 74
A+ PA AA + PG G G D ++C VCGD SSGKHYG + C GC FFKRS
Sbjct: 49 ASTPAQTAAGGQGGPG--GPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRS 106
Query: 75 VRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDS 134
VRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P T H
Sbjct: 107 VRRNLSYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMP-PTQPTHGQF 164
Query: 135 MESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADEN 194
+N + P++ H +++ I+ A+ P
Sbjct: 165 ALTNGD---------------------PLNC-----HSYLSGYISLLLRAEPYPTS---- 194
Query: 195 IDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLE 254
F S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL
Sbjct: 195 --------RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLR 246
Query: 255 EAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALA 314
WSELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL
Sbjct: 247 LTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALH 306
Query: 315 VDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLL 374
VD E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP RFGKLLL
Sbjct: 307 VDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLR 366
Query: 375 LPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
LPSLR +++ IE LFF + +G TP+E L+ DM
Sbjct: 367 LPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDM 399
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 273 bits (699), Expect = 2e-73
Identities = 159/406 (39%), Positives = 224/406 (55%), Gaps = 63/406 (15%)
Query: 20 AGAASRKESPGRWGL----------GEDPTGVSPS---LQCRVCGDSSSGKHYGIYACNG 66
+GA ++PG+ G G+ P G S ++C VCGD SSGKHYG + C G
Sbjct: 46 SGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEG 105
Query: 67 CSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRS 126
C FFKRSVRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P +
Sbjct: 106 CKSFFKRSVRRNLTYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPT 164
Query: 127 TAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKL 186
P P + P++ GH +++ I+ +
Sbjct: 165 Q----------------------PNPGQYALTNGDPLN-----GHCYLSGYISL--LLRA 195
Query: 187 EPEDADENIDVTSNDPEFPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVF 241
EP +P+S Y S ++ G+++I E +ARLLF AV+WA+N+P F
Sbjct: 196 EP---------------YPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF 240
Query: 242 SSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETR 301
L DQV LL WSELF+L A Q S+PL PLLA A+ + R+ R
Sbjct: 241 PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR 300
Query: 302 VLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHH 361
+ QE + + +AL VD E++C+KA+VLF + GL D H+E+LQ++SQ L ++ ++ +
Sbjct: 301 IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY 360
Query: 362 PSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
P+QP RFGKLLL LPSLR +++ IE LFF + +G TP+E L+ DM
Sbjct: 361 PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDM 406
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 221 bits (562), Expect = 1e-57
Identities = 142/413 (34%), Positives = 209/413 (50%), Gaps = 65/413 (15%)
Query: 10 SSTVAAAAPAAGAASRKESPGRWGLGED--PTGVSPSLQ---CRVCGDSSSGKHYGIYAC 64
SS + + + K PG G+G P+ SL C +CGD SSGKHYG+Y+C
Sbjct: 97 SSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSC 156
Query: 65 NGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ- 123
GC GFFKR++R+ LIY C+ C +DK RN+CQ CR +KCL GM ++AVQ ERQ
Sbjct: 157 EGCKGFFKRTIRKDLIYTCRDNKD-CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQR 215
Query: 124 PRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETC 183
R A+ + S E P + ++ AE
Sbjct: 216 SRERAESEAECATSGHEDMP------------------------------VERILEAELA 245
Query: 184 AKLEPED-ADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFS 242
+ + E D N++ ++NDP + +I + + LF V+WAK +P FS
Sbjct: 246 VEPKTESYGDMNMENSTNDP--------------VTNICHAADKQLFTLVEWAKRIPHFS 291
Query: 243 SLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAP------PEASAAGGAQGRLTLA 296
L DQVILL W+EL + S+ + LLA A +AG +
Sbjct: 292 DLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAG-------VG 344
Query: 297 SMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQH 356
S+ RVL E +S+ + + +D +E C++A+VLF P+ +GL +P VE L+++ L +
Sbjct: 345 SIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAY 404
Query: 357 SKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFK 409
+K +P QP RF KLLL LP+LR I + +E LFF K IG+TP++ L +M +
Sbjct: 405 TKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 457
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 219 bits (559), Expect = 3e-57
Identities = 132/364 (36%), Positives = 190/364 (52%), Gaps = 43/364 (11%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C +CGD SSGKHYG+Y+C GC GFFKR+VR+ L Y C+ C +DK RN+CQ CR +
Sbjct: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKD-CLIDKRQRNRCQYCRYQ 193
Query: 107 KCLQAGMNQDAVQNERQP-RSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSA 165
KCL GM ++AVQ ERQ + + ++S S E P + A P+ T + A
Sbjct: 194 KCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILE-AELAVEPKTETYVEA 252
Query: 166 ARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSA 225
L +P P+ P ++ I + +
Sbjct: 253 NMGL-------------------------------NPSSPNDPVTN--------ICQAAD 273
Query: 226 RLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASA 285
+ LF V+WAK +P FS LP DQVILL W+EL + S+ + LLA
Sbjct: 274 KQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVH 333
Query: 286 AGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEAL 345
A + ++ RVL E +S+ R + +D TE C++A+VLF P+++GL +P VEAL
Sbjct: 334 RNSAHSA-GVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEAL 392
Query: 346 QDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLC 405
+++ L + K +P QP RF KLLL LP+LR I + +E LFF K IG+TP++ L
Sbjct: 393 REKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM 452
Query: 406 DMFK 409
+M +
Sbjct: 453 EMLE 456
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 216 bits (551), Expect = 2e-56
Identities = 139/406 (34%), Positives = 200/406 (49%), Gaps = 45/406 (11%)
Query: 9 MSSTVAAAAPAAGAASRKESP--GRWGLGEDPTGVSPSLQ---CRVCGDSSSGKHYGIYA 63
++STV+ +G + P G GL P P C +CGD SSGKHYG+Y+
Sbjct: 162 INSTVSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYS 221
Query: 64 CNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQ 123
C GC GFFKR++R+ L Y C+ C VDK RN+CQ CR +KCL GM ++AVQ ERQ
Sbjct: 222 CEGCKGFFKRTIRKDLTYSCRDNKD-CTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQ 280
Query: 124 PRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETC 183
D PE + P R ++ AE
Sbjct: 281 RGKDK----DGDGEGAGGAPEEM-----PVDR---------------------ILEAELA 310
Query: 184 AKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSS 243
+ + + E T P+ P ++ I + + + LF V+WAK +P FSS
Sbjct: 311 VEQKSDQGVEGPGGTGGSGSSPNDPVTN--------ICQAADKQLFTLVEWAKRIPHFSS 362
Query: 244 LPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVL 303
LP DQVILL W+EL + S+ + LLA A + ++ RVL
Sbjct: 363 LPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSA-GVGAIFDRVL 421
Query: 304 QETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPS 363
E +S+ R + +D TE C++A++LF P+ +GL +P VE L+++ L + K +P
Sbjct: 422 TELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPE 481
Query: 364 QPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFK 409
Q RF KLLL LP+LR I + +E LFF K IG+TP++ L +M +
Sbjct: 482 QQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLE 527
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 186 bits (472), Expect = 3e-47
Identities = 113/361 (31%), Positives = 176/361 (48%), Gaps = 48/361 (13%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C +CGD ++GKHYG +C+GC GFF+RS+R+ +Y C+ C VDK RNQC+ CRL+
Sbjct: 49 CAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSR-QCVVDKDKRNQCRYCRLR 107
Query: 107 KCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAA 166
KC +AGM ++AVQNER ST + D
Sbjct: 108 KCFRAGMKKEAVQNERDRISTRRSTFDG-------------------------------- 135
Query: 167 RALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSAR 226
+++ + T A+ E ++ + + +S + + E+ +
Sbjct: 136 --------SNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIAS-----IGDVCESMKQ 182
Query: 227 LLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAA 286
L + V+WAK +P F LP DQV LL E LLGA + S+ LL
Sbjct: 183 QLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHR 242
Query: 287 GGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQ 346
+ + ++ + RVL E + F+ + +D E+AC+KA+V F P+ +GL DP ++ ++
Sbjct: 243 NSCE--VEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMR 300
Query: 347 DQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCD 406
Q Q+ L + RFG+LLLLLP+L+ IT + IE + F K G ++ LL +
Sbjct: 301 FQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQE 360
Query: 407 M 407
M
Sbjct: 361 M 361
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 184 bits (468), Expect = 1e-46
Identities = 130/396 (32%), Positives = 187/396 (47%), Gaps = 47/396 (11%)
Query: 12 TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71
+V A A +S SP P + S C +CGD ++GKHYG +C+GC GFF
Sbjct: 3 SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
Query: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
+RSVR+ +Y C+ + C VDK RNQC+ CRLKKC +AGM ++AVQNER ST +
Sbjct: 63 RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
Query: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191
S +S S+ A S + +P+S I + AK A
Sbjct: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
Query: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251
D + E+ L + V+WAK +P F LP DQV
Sbjct: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311
LL E LLGA + S+ LL + ++ + R+L E + F+
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
Query: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKL 371
L +D E+A +KA++ F P+ +GL DP ++ L+ Q QV L + RFG+L
Sbjct: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGEL 315
Query: 372 LLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
LLLLP+L+ IT + IE + F K G ++ LL +M
Sbjct: 316 LLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 184 bits (468), Expect = 1e-46
Identities = 130/396 (32%), Positives = 187/396 (47%), Gaps = 47/396 (11%)
Query: 12 TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71
+V A A +S SP P + S C +CGD ++GKHYG +C+GC GFF
Sbjct: 3 SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
Query: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
+RSVR+ +Y C+ + C VDK RNQC+ CRLKKC +AGM ++AVQNER ST +
Sbjct: 63 RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
Query: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191
S +S S+ A S + +P+S I + AK A
Sbjct: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
Query: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251
D + E+ L + V+WAK +P F LP DQV
Sbjct: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311
LL E LLGA + S+ LL + ++ + R+L E + F+
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
Query: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKL 371
L +D E+A +KA++ F P+ +GL DP ++ L+ Q QV L + RFG+L
Sbjct: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGEL 315
Query: 372 LLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
LLLLP+L+ IT + IE + F K G ++ LL +M
Sbjct: 316 LLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 184 bits (468), Expect = 1e-46
Identities = 130/396 (32%), Positives = 187/396 (47%), Gaps = 47/396 (11%)
Query: 12 TVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFF 71
+V A A +S SP P + S C +CGD ++GKHYG +C+GC GFF
Sbjct: 3 SVNAPLGAPVESSYDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFF 62
Query: 72 KRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVH 131
+RSVR+ +Y C+ + C VDK RNQC+ CRLKKC +AGM ++AVQNER ST +
Sbjct: 63 RRSVRKNHMYSCRF-SRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRR-- 119
Query: 132 LDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDA 191
S +S S+ A S + +P+S I + AK A
Sbjct: 120 ----SSYEDSSLPSINALLQAEVLSRQITSPVSG------------INGDIRAKKIASIA 163
Query: 192 DENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVI 251
D + E+ L + V+WAK +P F LP DQV
Sbjct: 164 D---------------------------VCESMKEQLLVLVEWAKYIPAFCELPLDDQVA 196
Query: 252 LLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFR 311
LL E LLGA + S+ LL + ++ + R+L E + F+
Sbjct: 197 LLRAHAGEHLLLGATKRSMVFKDV-LLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQ 255
Query: 312 ALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKL 371
L +D E+A +KA++ F P+ +GL DP ++ L+ Q QV L + RFG+L
Sbjct: 256 ELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGEL 315
Query: 372 LLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
LLLLP+L+ IT + IE + F K G ++ LL +M
Sbjct: 316 LLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM 351
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 184 bits (467), Expect = 1e-46
Identities = 124/370 (33%), Positives = 179/370 (48%), Gaps = 47/370 (12%)
Query: 38 PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97
P + S C +CGD ++GKHYG +C+GC GFF+RSVR+ +Y C+ + C VDK R
Sbjct: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
Query: 98 NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157
NQC+ CRLKKC +AGM ++AVQNER ST + S +S S+ A S
Sbjct: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
Query: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217
+ +P+S I + AK AD
Sbjct: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
Query: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277
+ E+ L + V+WAK +P F LP DQV LL E LLGA + S+ L
Sbjct: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
Query: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337
L + ++ + R+L E + F+ L +D E+A +KA++ F P+ +GL
Sbjct: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
Query: 338 DPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGN 397
DP ++ L+ Q QV L + RFG+LLLLLP+L+ IT + IE + F K G
Sbjct: 304 DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM 363
Query: 398 TPMEKLLCDM 407
++ LL +M
Sbjct: 364 AKIDNLLQEM 373
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 184 bits (467), Expect = 1e-46
Identities = 124/370 (33%), Positives = 179/370 (48%), Gaps = 47/370 (12%)
Query: 38 PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97
P + S C +CGD ++GKHYG +C+GC GFF+RSVR+ +Y C+ + C VDK R
Sbjct: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
Query: 98 NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157
NQC+ CRLKKC +AGM ++AVQNER ST + S +S S+ A S
Sbjct: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
Query: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217
+ +P+S I + AK AD
Sbjct: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
Query: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277
+ E+ L + V+WAK +P F LP DQV LL E LLGA + S+ L
Sbjct: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
Query: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337
L + ++ + R+L E + F+ L +D E+A +KA++ F P+ +GL
Sbjct: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
Query: 338 DPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGN 397
DP ++ L+ Q QV L + RFG+LLLLLP+L+ IT + IE + F K G
Sbjct: 304 DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM 363
Query: 398 TPMEKLLCDM 407
++ LL +M
Sbjct: 364 AKIDNLLQEM 373
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 184 bits (467), Expect = 1e-46
Identities = 124/370 (33%), Positives = 179/370 (48%), Gaps = 47/370 (12%)
Query: 38 PTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHR 97
P + S C +CGD ++GKHYG +C+GC GFF+RSVR+ +Y C+ + C VDK R
Sbjct: 51 PNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRF-SRQCVVDKDKR 109
Query: 98 NQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSP 157
NQC+ CRLKKC +AGM ++AVQNER ST + S +S S+ A S
Sbjct: 110 NQCRYCRLKKCFRAGMKKEAVQNERDRISTRR------SSYEDSSLPSINALLQAEVLSR 163
Query: 158 RGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGL 217
+ +P+S I + AK AD
Sbjct: 164 QITSPVSG------------INGDIRAKKIASIAD------------------------- 186
Query: 218 DSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPL 277
+ E+ L + V+WAK +P F LP DQV LL E LLGA + S+ L
Sbjct: 187 --VCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDV-L 243
Query: 278 LAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLK 337
L + ++ + R+L E + F+ L +D E+A +KA++ F P+ +GL
Sbjct: 244 LLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLS 303
Query: 338 DPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGN 397
DP ++ L+ Q QV L + RFG+LLLLLP+L+ IT + IE + F K G
Sbjct: 304 DPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGM 363
Query: 398 TPMEKLLCDM 407
++ LL +M
Sbjct: 364 AKIDNLLQEM 373
>gi|223555953 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 177 bits (449), Expect = 2e-44
Identities = 92/209 (44%), Positives = 135/209 (64%), Gaps = 5/209 (2%)
Query: 204 FPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWS 258
+P+S + S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL WS
Sbjct: 38 YPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS 97
Query: 259 ELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPT 318
ELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL VD
Sbjct: 98 ELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSA 157
Query: 319 EFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSL 378
E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP RFGKLLL LPSL
Sbjct: 158 EYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSL 217
Query: 379 RFITAERIELLFFRKTIGNTPMEKLLCDM 407
R +++ IE LFF + +G TP+E L+ DM
Sbjct: 218 RTVSSSVIEQLFFVRLVGKTPIETLIRDM 246
>gi|223555951 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 177 bits (449), Expect = 2e-44
Identities = 92/209 (44%), Positives = 135/209 (64%), Gaps = 5/209 (2%)
Query: 204 FPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWS 258
+P+S + S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL WS
Sbjct: 38 YPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS 97
Query: 259 ELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPT 318
ELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL VD
Sbjct: 98 ELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSA 157
Query: 319 EFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSL 378
E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP RFGKLLL LPSL
Sbjct: 158 EYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSL 217
Query: 379 RFITAERIELLFFRKTIGNTPMEKLLCDM 407
R +++ IE LFF + +G TP+E L+ DM
Sbjct: 218 RTVSSSVIEQLFFVRLVGKTPIETLIRDM 246
>gi|223555949 nuclear receptor subfamily 2, group F, member 2
isoform b [Homo sapiens]
Length = 281
Score = 177 bits (449), Expect = 2e-44
Identities = 92/209 (44%), Positives = 135/209 (64%), Gaps = 5/209 (2%)
Query: 204 FPSSPYSS-----SSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWS 258
+P+S + S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL WS
Sbjct: 58 YPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS 117
Query: 259 ELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPT 318
ELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL VD
Sbjct: 118 ELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSA 177
Query: 319 EFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSL 378
E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP RFGKLLL LPSL
Sbjct: 178 EYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSL 237
Query: 379 RFITAERIELLFFRKTIGNTPMEKLLCDM 407
R +++ IE LFF + +G TP+E L+ DM
Sbjct: 238 RTVSSSVIEQLFFVRLVGKTPIETLIRDM 266
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 162 bits (409), Expect = 7e-40
Identities = 111/367 (30%), Positives = 172/367 (46%), Gaps = 35/367 (9%)
Query: 43 PSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQA 102
P C VCGD +SG HYG+ +C C FFKR+++ + Y C C + K R CQA
Sbjct: 99 PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA-TNECEITKRRRKSCQA 157
Query: 103 CRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTP 162
CR KCL+ GM ++ V+ +R R Q + ++S + ++PPA P
Sbjct: 158 CRFMKCLKVGMLKEGVRLDRV-RGGRQKYKRRLDSESSPYLSLQISPPAKK--------P 208
Query: 163 MSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHE 222
++ ++ L+ AE P+ P P + L ++ +
Sbjct: 209 LTK-------IVSYLLVAE------PDKL-----YAMPPPGMPEGDIKA-----LTTLCD 245
Query: 223 TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPE 282
+ R L + + WAK++P FSSL DQ+ LL+ AW E+ +LG + SLP D + A E
Sbjct: 246 LADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYA--E 303
Query: 283 ASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHV 342
RL R + + + R++ L V+ EF +KAL L ++ ++D E V
Sbjct: 304 DYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAV 363
Query: 343 EALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEK 402
+ LQD L + + +P R GKLLL LP LR A+ ++ + K G PM K
Sbjct: 364 QKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHK 423
Query: 403 LLCDMFK 409
L +M +
Sbjct: 424 LFLEMLE 430
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 155 bits (393), Expect = 5e-38
Identities = 104/368 (28%), Positives = 172/368 (46%), Gaps = 37/368 (10%)
Query: 43 PSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQA 102
P C VCGD +SG HYG+ +C C FFKR+++ + Y C C + K R CQA
Sbjct: 101 PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA-TNECEITKRRRKSCQA 159
Query: 103 CRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTP 162
CR KCL+ GM ++ V+ LD + + + A +P P
Sbjct: 160 CRFMKCLKVGMLKEGVR------------LDRVRGGRQKYKRRIDAENSPY----LNPQL 203
Query: 163 MSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHE 222
+ A+ + ++ L+ AE PE DP P S + L ++ +
Sbjct: 204 VQPAKKPYNKIVSHLLVAE------PEKI-----YAMPDPTVPDSDIKA-----LTTLCD 247
Query: 223 TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPE 282
+ R L + + WAK++P FS+L DQ+ LL+ AW E+ +LG + SL + + A +
Sbjct: 248 LADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYA--D 305
Query: 283 ASAAGGAQGRLT-LASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEH 341
Q +L L + +LQ + +++++ ++ EF +KA+ L ++ ++D E
Sbjct: 306 DYIMDEDQSKLAGLLDLNNAILQ-LVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEA 364
Query: 342 VEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPME 401
V+ LQD L + H P R GK+L+ LP LR + + ++ + K G PM
Sbjct: 365 VQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMH 424
Query: 402 KLLCDMFK 409
KL +M +
Sbjct: 425 KLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 155 bits (393), Expect = 5e-38
Identities = 104/368 (28%), Positives = 172/368 (46%), Gaps = 37/368 (10%)
Query: 43 PSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQA 102
P C VCGD +SG HYG+ +C C FFKR+++ + Y C C + K R CQA
Sbjct: 101 PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA-TNECEITKRRRKSCQA 159
Query: 103 CRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTP 162
CR KCL+ GM ++ V+ LD + + + A +P P
Sbjct: 160 CRFMKCLKVGMLKEGVR------------LDRVRGGRQKYKRRIDAENSPY----LNPQL 203
Query: 163 MSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHE 222
+ A+ + ++ L+ AE PE DP P S + L ++ +
Sbjct: 204 VQPAKKPYNKIVSHLLVAE------PEKI-----YAMPDPTVPDSDIKA-----LTTLCD 247
Query: 223 TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPE 282
+ R L + + WAK++P FS+L DQ+ LL+ AW E+ +LG + SL + + A +
Sbjct: 248 LADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYA--D 305
Query: 283 ASAAGGAQGRLT-LASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEH 341
Q +L L + +LQ + +++++ ++ EF +KA+ L ++ ++D E
Sbjct: 306 DYIMDEDQSKLAGLLDLNNAILQ-LVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEA 364
Query: 342 VEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPME 401
V+ LQD L + H P R GK+L+ LP LR + + ++ + K G PM
Sbjct: 365 VQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMH 424
Query: 402 KLLCDMFK 409
KL +M +
Sbjct: 425 KLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 155 bits (393), Expect = 5e-38
Identities = 104/368 (28%), Positives = 172/368 (46%), Gaps = 37/368 (10%)
Query: 43 PSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQA 102
P C VCGD +SG HYG+ +C C FFKR+++ + Y C C + K R CQA
Sbjct: 124 PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA-TNECEITKRRRKSCQA 182
Query: 103 CRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTP 162
CR KCL+ GM ++ V+ LD + + + A +P P
Sbjct: 183 CRFMKCLKVGMLKEGVR------------LDRVRGGRQKYKRRIDAENSPY----LNPQL 226
Query: 163 MSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHE 222
+ A+ + ++ L+ AE PE DP P S + L ++ +
Sbjct: 227 VQPAKKPYNKIVSHLLVAE------PEKI-----YAMPDPTVPDSDIKA-----LTTLCD 270
Query: 223 TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPE 282
+ R L + + WAK++P FS+L DQ+ LL+ AW E+ +LG + SL + + A +
Sbjct: 271 LADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYA--D 328
Query: 283 ASAAGGAQGRLT-LASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEH 341
Q +L L + +LQ + +++++ ++ EF +KA+ L ++ ++D E
Sbjct: 329 DYIMDEDQSKLAGLLDLNNAILQ-LVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEA 387
Query: 342 VEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPME 401
V+ LQD L + H P R GK+L+ LP LR + + ++ + K G PM
Sbjct: 388 VQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMH 447
Query: 402 KLLCDMFK 409
KL +M +
Sbjct: 448 KLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 155 bits (393), Expect = 5e-38
Identities = 104/368 (28%), Positives = 172/368 (46%), Gaps = 37/368 (10%)
Query: 43 PSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQA 102
P C VCGD +SG HYG+ +C C FFKR+++ + Y C C + K R CQA
Sbjct: 101 PKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPA-TNECEITKRRRKSCQA 159
Query: 103 CRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTP 162
CR KCL+ GM ++ V+ LD + + + A +P P
Sbjct: 160 CRFMKCLKVGMLKEGVR------------LDRVRGGRQKYKRRIDAENSPY----LNPQL 203
Query: 163 MSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHE 222
+ A+ + ++ L+ AE PE DP P S + L ++ +
Sbjct: 204 VQPAKKPYNKIVSHLLVAE------PEKI-----YAMPDPTVPDSDIKA-----LTTLCD 247
Query: 223 TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPE 282
+ R L + + WAK++P FS+L DQ+ LL+ AW E+ +LG + SL + + A +
Sbjct: 248 LADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYA--D 305
Query: 283 ASAAGGAQGRLT-LASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEH 341
Q +L L + +LQ + +++++ ++ EF +KA+ L ++ ++D E
Sbjct: 306 DYIMDEDQSKLAGLLDLNNAILQ-LVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEA 364
Query: 342 VEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPME 401
V+ LQD L + H P R GK+L+ LP LR + + ++ + K G PM
Sbjct: 365 VQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMH 424
Query: 402 KLLCDMFK 409
KL +M +
Sbjct: 425 KLFLEMLE 432
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 150 bits (379), Expect = 2e-36
Identities = 118/420 (28%), Positives = 180/420 (42%), Gaps = 42/420 (10%)
Query: 2 ETRPTALMSSTVAAAAPAAGAASRKES----PGRWGLGEDPTGVSPSLQCRVCGDSSSGK 57
ET P ++ A G ++ PG G G+ P C VCGD +SG
Sbjct: 30 ETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGY 89
Query: 58 HYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDA 117
HYG+ +C C FFKR+++ + Y C + C + K R CQACR KCL+ GM ++
Sbjct: 90 HYGVASCEACKAFFKRTIQGSIEYSCP-ASNECEITKRRRKACQACRFTKCLRVGMLKEG 148
Query: 118 VQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASL 177
V+ +R R Q + E + P A P PR + AL H +
Sbjct: 149 VRLDR-VRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPR--KTAAPVNALVSHLLV-- 203
Query: 178 ITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKN 237
+EPE D D P+ + ++ + R + + + WAK+
Sbjct: 204 --------VEPEKLYAMPDPAGPDGHLPA----------VATLCDLFDREIVVTISWAKS 245
Query: 238 LPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDS----CPLLAPPEASAAGGAQGRL 293
+P FSSL DQ+ +L+ W E+ +LG Q SLPL L E A G L
Sbjct: 246 IPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGEL 305
Query: 294 TLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVML 353
A L + + R +AL ++ E+ +KAL L ++ ++D E VE L++ L
Sbjct: 306 GAA------LLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEAL 359
Query: 354 SQHSKAH----HPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFK 409
++ ++ R G+LLL LP LR + + + K G PM KL +M +
Sbjct: 360 LEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLE 419
>gi|170295804 estrogen receptor alpha isoform 4 [Homo sapiens]
Length = 595
Score = 147 bits (372), Expect = 1e-35
Identities = 108/375 (28%), Positives = 175/375 (46%), Gaps = 30/375 (8%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C VC D +SG HYG+++C GC FFKRS++ Y C C +DK R CQACRL+
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCP-ATNQCTIDKNRRKSCQACRLR 243
Query: 107 KCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAA 166
KC + GM + ++ +R R + + E R E V + P+P+
Sbjct: 244 KCYEVGMMKGGIRKDR--RGGRMLKHKRQRDDGEGRGE--VGSAGDMRAANLWPSPLMIK 299
Query: 167 RALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSAR 226
R+ + SL + + L DA+ I + D P+ P+S +S GL + + R
Sbjct: 300 RSKKNSLALSLTADQMVSAL--LDAEPPILYSEYD---PTRPFSEASMMGL--LTNLADR 352
Query: 227 LLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPP---EA 283
L + WAK +P F L DQV LLE AW E+ ++G + S+ L AP +
Sbjct: 353 ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR 412
Query: 284 SAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVL--------FKPETRG 335
+ +G + + M L T SRFR + + EF C+K+++L +
Sbjct: 413 NQGKCVEGMVEIFDM----LLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKS 468
Query: 336 LKDPEHVEALQDQ---SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFR 392
L++ +H+ + D+ + + L + Q R +LLL+L +R ++ + +E L+
Sbjct: 469 LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 528
Query: 393 KTIGNTPMEKLLCDM 407
K P+ LL +M
Sbjct: 529 KCKNVVPLYDLLLEM 543
>gi|170295802 estrogen receptor alpha isoform 3 [Homo sapiens]
Length = 595
Score = 147 bits (372), Expect = 1e-35
Identities = 108/375 (28%), Positives = 175/375 (46%), Gaps = 30/375 (8%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C VC D +SG HYG+++C GC FFKRS++ Y C C +DK R CQACRL+
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCP-ATNQCTIDKNRRKSCQACRLR 243
Query: 107 KCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAA 166
KC + GM + ++ +R R + + E R E V + P+P+
Sbjct: 244 KCYEVGMMKGGIRKDR--RGGRMLKHKRQRDDGEGRGE--VGSAGDMRAANLWPSPLMIK 299
Query: 167 RALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSAR 226
R+ + SL + + L DA+ I + D P+ P+S +S GL + + R
Sbjct: 300 RSKKNSLALSLTADQMVSAL--LDAEPPILYSEYD---PTRPFSEASMMGL--LTNLADR 352
Query: 227 LLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPP---EA 283
L + WAK +P F L DQV LLE AW E+ ++G + S+ L AP +
Sbjct: 353 ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR 412
Query: 284 SAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVL--------FKPETRG 335
+ +G + + M L T SRFR + + EF C+K+++L +
Sbjct: 413 NQGKCVEGMVEIFDM----LLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKS 468
Query: 336 LKDPEHVEALQDQ---SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFR 392
L++ +H+ + D+ + + L + Q R +LLL+L +R ++ + +E L+
Sbjct: 469 LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 528
Query: 393 KTIGNTPMEKLLCDM 407
K P+ LL +M
Sbjct: 529 KCKNVVPLYDLLLEM 543
>gi|170295800 estrogen receptor alpha isoform 2 [Homo sapiens]
Length = 595
Score = 147 bits (372), Expect = 1e-35
Identities = 108/375 (28%), Positives = 175/375 (46%), Gaps = 30/375 (8%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C VC D +SG HYG+++C GC FFKRS++ Y C C +DK R CQACRL+
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCP-ATNQCTIDKNRRKSCQACRLR 243
Query: 107 KCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAA 166
KC + GM + ++ +R R + + E R E V + P+P+
Sbjct: 244 KCYEVGMMKGGIRKDR--RGGRMLKHKRQRDDGEGRGE--VGSAGDMRAANLWPSPLMIK 299
Query: 167 RALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSAR 226
R+ + SL + + L DA+ I + D P+ P+S +S GL + + R
Sbjct: 300 RSKKNSLALSLTADQMVSAL--LDAEPPILYSEYD---PTRPFSEASMMGL--LTNLADR 352
Query: 227 LLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPP---EA 283
L + WAK +P F L DQV LLE AW E+ ++G + S+ L AP +
Sbjct: 353 ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR 412
Query: 284 SAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVL--------FKPETRG 335
+ +G + + M L T SRFR + + EF C+K+++L +
Sbjct: 413 NQGKCVEGMVEIFDM----LLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKS 468
Query: 336 LKDPEHVEALQDQ---SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFR 392
L++ +H+ + D+ + + L + Q R +LLL+L +R ++ + +E L+
Sbjct: 469 LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 528
Query: 393 KTIGNTPMEKLLCDM 407
K P+ LL +M
Sbjct: 529 KCKNVVPLYDLLLEM 543
>gi|62821794 estrogen receptor alpha isoform 1 [Homo sapiens]
Length = 595
Score = 147 bits (372), Expect = 1e-35
Identities = 108/375 (28%), Positives = 175/375 (46%), Gaps = 30/375 (8%)
Query: 47 CRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLK 106
C VC D +SG HYG+++C GC FFKRS++ Y C C +DK R CQACRL+
Sbjct: 185 CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCP-ATNQCTIDKNRRKSCQACRLR 243
Query: 107 KCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAA 166
KC + GM + ++ +R R + + E R E V + P+P+
Sbjct: 244 KCYEVGMMKGGIRKDR--RGGRMLKHKRQRDDGEGRGE--VGSAGDMRAANLWPSPLMIK 299
Query: 167 RALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSAR 226
R+ + SL + + L DA+ I + D P+ P+S +S GL + + R
Sbjct: 300 RSKKNSLALSLTADQMVSAL--LDAEPPILYSEYD---PTRPFSEASMMGL--LTNLADR 352
Query: 227 LLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPP---EA 283
L + WAK +P F L DQV LLE AW E+ ++G + S+ L AP +
Sbjct: 353 ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR 412
Query: 284 SAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVL--------FKPETRG 335
+ +G + + M L T SRFR + + EF C+K+++L +
Sbjct: 413 NQGKCVEGMVEIFDM----LLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKS 468
Query: 336 LKDPEHVEALQDQ---SQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFR 392
L++ +H+ + D+ + + L + Q R +LLL+L +R ++ + +E L+
Sbjct: 469 LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSM 528
Query: 393 KTIGNTPMEKLLCDM 407
K P+ LL +M
Sbjct: 529 KCKNVVPLYDLLLEM 543
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 138 bits (347), Expect = 1e-32
Identities = 110/370 (29%), Positives = 163/370 (44%), Gaps = 50/370 (13%)
Query: 46 QCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRL 105
+C VCGD++S +HYG+ C GC GFFKR+V++ Y C CPVDK RN+CQ CR
Sbjct: 266 RCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKD-CPVDKRRRNRCQFCRF 324
Query: 106 KKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSA 165
+KCL GM ++ V+ DS++ P P+ P S
Sbjct: 325 QKCLAVGMVKEVVRT------------DSLKGRRGRLPS-----------KPKQPPDASP 361
Query: 166 ARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCG-LDSIHETS 224
A L A L + + AKL+ E + P+ G + ++
Sbjct: 362 ANLLTSLVRAHLDSGPSTAKLDYSKFQELV-----------LPHFGKEDAGDVQQFYDLL 410
Query: 225 ARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLP----LDSCPLLAP 280
+ L + KWA+ +P F+ L DQ +LLE A+ ELF+L S P L C L
Sbjct: 411 SGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVL 470
Query: 281 PEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPE 340
A G + +R L +L VD FAC+ ALVL + GL++P
Sbjct: 471 HRLQCARGFGDWIDSILAFSRSL-------HSLLVDVPAFACLSALVLI-TDRHGLQEPR 522
Query: 341 HVEALQDQSQVMLSQH--SKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNT 398
VE LQ++ L +H + A P +LL LP LR + + ++ +F+ K
Sbjct: 523 RVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLV 582
Query: 399 PMEKLLCDMF 408
P ++ +F
Sbjct: 583 PPPPIIDKIF 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,110,785
Number of Sequences: 37866
Number of extensions: 815328
Number of successful extensions: 4866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 4424
Number of HSP's gapped (non-prelim): 304
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.