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Search of human proteins with 74136023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74136023 delta-like 1 homolog [Homo sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74136023 delta-like 1 homolog [Homo sapiens] 832 0.0
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 241 8e-64
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 241 8e-64
gi|110735443 delta-like 1 [Homo sapiens] 224 1e-58
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 216 4e-56
gi|4557679 jagged 1 precursor [Homo sapiens] 203 2e-52
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 201 7e-52
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 198 8e-51
gi|24041035 notch 2 preproprotein [Homo sapiens] 168 9e-42
gi|148833508 notch1 preproprotein [Homo sapiens] 162 5e-40
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 160 2e-39
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 160 2e-39
gi|134244285 Notch homolog 3 [Homo sapiens] 158 7e-39
gi|112420992 crumbs homolog 2 [Homo sapiens] 157 2e-38
gi|148886654 polydom [Homo sapiens] 154 2e-37
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 150 2e-36
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 150 2e-36
gi|55770876 notch4 preproprotein [Homo sapiens] 147 2e-35
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 143 3e-34
gi|122937283 6720455I24Rik homolog [Homo sapiens] 142 7e-34
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 140 2e-33
gi|4759146 slit homolog 2 [Homo sapiens] 135 5e-32
gi|188528675 slit homolog 1 [Homo sapiens] 135 6e-32
gi|11321571 slit homolog 3 [Homo sapiens] 125 5e-29
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 117 1e-26
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 117 1e-26
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 115 5e-26
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 113 3e-25
gi|153946395 tenascin C precursor [Homo sapiens] 110 2e-24
gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens] 109 5e-24
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 832 bits (2149), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
Sbjct: 1 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60
Query: 61 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 120
PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
Sbjct: 61 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS 120
Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180
GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
Sbjct: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180
Query: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240
NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
Sbjct: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240
Query: 241 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 300
GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
Sbjct: 241 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT 300
Query: 301 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 360
EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
Sbjct: 301 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA 360
Query: 361 VNIIFPEKIDMTTFSKEAGDEEI 383
VNIIFPEKIDMTTFSKEAGDEEI
Sbjct: 361 VNIIFPEKIDMTTFSKEAGDEEI 383
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 241 bits (615), Expect = 8e-64
Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)
Query: 7 LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66
L+ +L +L A G +C C+ +G C D CRC PGW+G C++CV PGC HG
Sbjct: 10 LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69
Query: 67 LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
C +P QCIC GW G+ CD+D C++ +PC N G C+ G Y C C PG+ G+DC+
Sbjct: 70 TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
+K GPC GSPC++GG C DD+G A + +C C GF G CE+ + C PC N C
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244
D F C CP GF + C+ + +CAS PCQ G C ++CLC + G TC
Sbjct: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
Query: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303
+ P P G A + P P +L++S+KE+ ++ L E
Sbjct: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306
Query: 304 AICFTILGVLTSLVVLGTV 322
+ + G LT+ +VL TV
Sbjct: 307 LVALVVFGALTAALVLATV 325
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 241 bits (615), Expect = 8e-64
Identities = 120/319 (37%), Positives = 167/319 (52%), Gaps = 6/319 (1%)
Query: 7 LLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG 66
L+ +L +L A G +C C+ +G C D CRC PGW+G C++CV PGC HG
Sbjct: 10 LVCLLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHG 69
Query: 67 LCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
C +P QCIC GW G+ CD+D C++ +PC N G C+ G Y C C PG+ G+DC+
Sbjct: 70 TCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE 129
Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
+K GPC GSPC++GG C DD+G A + +C C GF G CE+ + C PC N C
Sbjct: 130 RKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATC 189
Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC- 244
D F C CP GF + C+ + +CAS PCQ G C ++CLC + G TC
Sbjct: 190 LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVH-DFDCLCPSGYGGKTCE 248
Query: 245 VKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPL-LTEGQ 303
+ P P G A + P P +L++S+KE+ ++ L E
Sbjct: 249 LVLPVPDPPTTVDTPLGPTSAV-VVPATGPAP-HSAGAGLLRISVKEVVRRQEAGLGEPS 306
Query: 304 AICFTILGVLTSLVVLGTV 322
+ + G LT+ +VL TV
Sbjct: 307 LVALVVFGALTAALVLATV 325
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 224 bits (571), Expect = 1e-58
Identities = 102/249 (40%), Positives = 135/249 (54%), Gaps = 26/249 (10%)
Query: 16 AFGHSTYGAE------------------CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQC 57
AFGH T G C P C+ Q+GFC+ C+C+ GWQG CD+C
Sbjct: 198 AFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDEC 257
Query: 58 VTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACS-SAPCANNGTCVSLDDGLYECSCA 116
+ PGCLHG C +P QC C +GW G C++D+ C+ PC N TC + G Y CSC
Sbjct: 258 IRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCR 317
Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
PGY+G C+ C + SPC++GG+C D E + SC CPPGF G CE+ A +C
Sbjct: 318 PGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTCAD 372
Query: 177 NPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
PC N G C+D G + CRCP G+ C + + C+SSPC NG C+ +Y C C
Sbjct: 373 GPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLCRC 431
Query: 236 KPEFTGLTC 244
+ F+G C
Sbjct: 432 QAGFSGRHC 440
Score = 176 bits (446), Expect = 3e-44
Identities = 84/233 (36%), Positives = 115/233 (49%), Gaps = 18/233 (7%)
Query: 22 YGAECFPACNPQNGF-----CEDDNVCRCQPGWQGPLCDQCVTSPGC--LHGLCGEPGQC 74
YG C C P++ C + C PGW+GP C + + PGC HG C +PG+C
Sbjct: 184 YGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGEC 243
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
C GW G CD C P +GTC ++C+C G+ G C + C +
Sbjct: 244 KCRVGWQGRYCDE----CIRYPGCLHGTCQQP----WQCNCQEGWGGLFCNQDLNYCT-H 294
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
PC++G TC + G+ S+ +C C PG++G CE+ + C P+PC+N G CTD+ + C
Sbjct: 295 HKPCKNGATCTNT-GQGSY-TCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSC 352
Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
CP GF K C CA PC NGG C Y C C ++G C KK
Sbjct: 353 TCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKK 405
Score = 162 bits (409), Expect = 6e-40
Identities = 79/209 (37%), Positives = 101/209 (48%), Gaps = 13/209 (6%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
C C+PG+ G C D+C SP G C + C C G+ G++C+ C+
Sbjct: 314 CSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADG 373
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
PC N G C DG Y C C GYSG +C+KK C + SPC +G CVD
Sbjct: 374 PCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYC--SSSPCSNGAKCVD---LGDAYL 428
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C C GFSG C+ + C +PC N G C D DF C CP G+ + CS PV+ C +
Sbjct: 429 CRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHA 488
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
PC NG TC + Y C C + G C
Sbjct: 489 PCHNGATCHERGH-RYVCECARGYGGPNC 516
Score = 92.0 bits (227), Expect = 8e-19
Identities = 53/150 (35%), Positives = 73/150 (48%), Gaps = 19/150 (12%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGL----CGEPGQCICTDGWDGELCDRDVRACSS 94
CRC G+ G C D C +SP C +G G+ C C G+ G CD +V C+S
Sbjct: 391 CRCPVGYSGFNCEKKIDYCSSSP-CSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCAS 449
Query: 95 APCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
+PCAN GTC DG+ + C+C PGY+G++C C +PC +G TC + R
Sbjct: 450 SPCANGGTC---RDGVNDFSCTCPPGYTGRNCSAPVSRC--EHAPCHNGATCHE---RGH 501
Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCEND 182
C C G+ G C+ + P P D
Sbjct: 502 RYVCECARGYGGPNCQFLLPELPPGPAVVD 531
Score = 68.2 bits (165), Expect = 1e-11
Identities = 39/108 (36%), Positives = 47/108 (43%), Gaps = 13/108 (12%)
Query: 39 DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRA 91
D +CRCQ G+ G CD C +SP G C + C C G+ G C V
Sbjct: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-----KKDGPCVIN 134
C APC N TC Y C CA GY G +CQ GP V++
Sbjct: 485 CEHAPCHNGATCHERGHR-YVCECARGYGGPNCQFLLPELPPGPAVVD 531
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 216 bits (549), Expect = 4e-56
Identities = 94/222 (42%), Positives = 123/222 (55%), Gaps = 9/222 (4%)
Query: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELC 85
C C+ QNG+C C C+PGWQG LC++C+ GC HG C P QC C +GW G C
Sbjct: 222 CLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFC 281
Query: 86 DRDVRACS-SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
D+D+ C+ +PC N TC + Y C+C PGY+G DC+ + C + +PC++GG+C
Sbjct: 282 DQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSEC--DSNPCRNGGSC 339
Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD--IGGDFRCRCPAGFID 202
D E CLCPPG+ G CE SC +PC N G C + G ++ C CP F
Sbjct: 340 KDQE---DGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTG 396
Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C + V C S+PC NGG CL S C C+P FTG C
Sbjct: 397 SNCEKKVDRCTSNPCANGGQCLNRGP-SRMCRCRPGFTGTYC 437
Score = 123 bits (309), Expect = 2e-28
Identities = 71/185 (38%), Positives = 89/185 (48%), Gaps = 19/185 (10%)
Query: 38 EDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQ-----CICTDGWDGELCDRD 88
ED C C PG+ G C+ C SP G C E Q C C + G C++
Sbjct: 343 EDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKK 402
Query: 89 VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
V C+S PCAN G C++ C C PG++G C+ C N PC HGGTC D E
Sbjct: 403 VDRCTSNPCANGGQCLNRGPSRM-CRCRPGFTGTYCELHVSDCARN--PCAHGGTCHDLE 459
Query: 149 GRASHASCLCPPGFSGNFCEI--VANSCTPNPCENDGVC-TDIGGD-FRCRCPAGFIDKT 204
+ C CP GFSG CE+ ++C +PC N C TD+ D F C CP GF+
Sbjct: 460 ---NGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSR 516
Query: 205 CSRPV 209
C PV
Sbjct: 517 CEFPV 521
Score = 93.2 bits (230), Expect = 3e-19
Identities = 55/162 (33%), Positives = 74/162 (45%), Gaps = 16/162 (9%)
Query: 19 HSTYGAECFPACNPQNGFCEDDN-----VCRCQPGWQGPLC----DQCVTSPGCLHGLC- 68
HST P N G C + N C C P + G C D+C ++P G C
Sbjct: 361 HSTLSCADSPCFN--GGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCL 418
Query: 69 --GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK 126
G C C G+ G C+ V C+ PCA+ GTC L++GL C+C G+SG+ C+
Sbjct: 419 NRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLM-CTCPAGFSGRRCEV 477
Query: 127 KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCE 168
+ SPC + TC D + C CP GF G+ CE
Sbjct: 478 RTSIDACASSPCFNRATCYTDLSTDTFV-CNCPYGFVGSRCE 518
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 203 bits (516), Expect = 2e-52
Identities = 87/222 (39%), Positives = 123/222 (55%), Gaps = 7/222 (3%)
Query: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
A C C+P++G C+ CRCQ GWQG CD+C+ PGC+HG+C EP QC+C W G+
Sbjct: 232 AICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQ 291
Query: 84 LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
LCD+D+ C + PC N GTC + Y+CSC GYSG +C+ + C+ PC + G
Sbjct: 292 LCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACL--SDPCHNRG 349
Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
+C + + C C PG++G C + C+PN C + G C D+ F+C CP +
Sbjct: 350 SCKE---TSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTG 406
Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
KTC C + PC N +C ++ SY C C P + G C
Sbjct: 407 KTCQLDANECEAKPCVNAKSC-KNLIASYYCDCLPGWMGQNC 447
Score = 160 bits (404), Expect = 2e-39
Identities = 88/269 (32%), Positives = 118/269 (43%), Gaps = 53/269 (19%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLH-GLCGEPG---- 72
Y +C P +G C + C C+ W G LCD+ C T CL+ G C G
Sbjct: 261 YCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKY 320
Query: 73 QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
QC C +G+ G C+ AC S PC N G+C G +EC C+PG++G C C
Sbjct: 321 QCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLG-FECECSPGWTGPTCSTNIDDCS 379
Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-------------- 178
N C HGGTC D + C+CPP ++G C++ AN C P
Sbjct: 380 PNN--CSHGGTCQD---LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY 434
Query: 179 -----------------------CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C+ND C D+ +RC CP G+ C R + CAS+
Sbjct: 435 YCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN 494
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
PC NGG C Q+ ++CLC F+G C
Sbjct: 495 PCLNGGHC-QNEINRFQCLCPTGFSGNLC 522
Score = 150 bits (378), Expect = 2e-36
Identities = 85/265 (32%), Positives = 114/265 (43%), Gaps = 58/265 (21%)
Query: 30 CNPQNGFCEDDN----VCRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQCICTD 78
C P +G C+ + C C G+ G C + C ++P G C + +CIC+D
Sbjct: 599 CGP-HGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSD 657
Query: 79 GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
GW+G C+ ++ CS PC N GTC L + Y C C G+ GK C +D C + + C
Sbjct: 658 GWEGAYCETNINDCSQNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQC--DEATC 714
Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANS------------------------- 173
+GGTC D EG A C+CP G+ G C I NS
Sbjct: 715 NNGGTCYD-EGDAF--KCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCK 771
Query: 174 --------------CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQN 219
C+P+PC N G C D +RC C GF C + C SSPC
Sbjct: 772 EGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAF 831
Query: 220 GGTCLQHTQVSYECLCKPEFTGLTC 244
G TC+ Y C+C P +G C
Sbjct: 832 GATCVDEIN-GYRCVCPPGHSGAKC 855
Score = 149 bits (375), Expect = 5e-36
Identities = 74/221 (33%), Positives = 104/221 (47%), Gaps = 20/221 (9%)
Query: 35 GFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHG-LCGE---PGQCICTDGWDGE 83
G C++ ++ C C PGW GP C D C + C HG C + +C+C W G+
Sbjct: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPN-NCSHGGTCQDLVNGFKCVCPPQWTGK 407
Query: 84 LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
C D C + PC N +C +L Y C C PG+ G++C C+ CQ+ +
Sbjct: 408 TCQLDANECEAKPCVNAKSCKNLIASYY-CDCLPGWMGQNCDININDCL---GQCQNDAS 463
Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
C D + C+CPPG++G+ CE + C NPC N G C + F+C CP GF
Sbjct: 464 CRD---LVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGN 520
Query: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C + C +PCQNG C Y C C ++ G C
Sbjct: 521 LCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNC 560
Score = 139 bits (350), Expect = 4e-33
Identities = 72/210 (34%), Positives = 102/210 (48%), Gaps = 25/210 (11%)
Query: 30 CNPQN----GFCED---DNVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPGQ 73
C+P N G C+D C C P W G C CV + C + +
Sbjct: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASY--Y 435
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C C GW G+ CD ++ C C N+ +C L +G Y C C PGY+G C++ C
Sbjct: 436 CDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCICPPGYAGDHCERDIDECAS 493
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
N PC +GG C ++ R CLCP GFSGN C++ + C PNPC+N C + D+
Sbjct: 494 N--PCLNGGHCQNEINRFQ---CLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYF 548
Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
C+CP + K CS +C ++PC+ +C
Sbjct: 549 CKCPEDYEGKNCSHLKDHCRTTPCEVIDSC 578
Score = 134 bits (338), Expect = 1e-31
Identities = 73/230 (31%), Positives = 103/230 (44%), Gaps = 34/230 (14%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQCICTD 78
GA+C+ + D C+C ++G C D C T+P C D
Sbjct: 537 GAQCYNRAS--------DYFCKCPEDYEGKNCSHLKDHCRTTP------------CEVID 576
Query: 79 GWDGELCDRD----VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
+ D VR SS C +G C S G + C C G++G C + C N
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESN 636
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
PC++GGTC+D + C+C G+ G +CE N C+ NPC N G C D+ DF C
Sbjct: 637 --PCRNGGTCIDG---VNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYC 691
Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C G+ KTC + C + C NGGTC +++C+C + G TC
Sbjct: 692 DCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGD-AFKCMCPGGWEGTTC 740
Score = 86.3 bits (212), Expect = 4e-17
Identities = 60/192 (31%), Positives = 80/192 (41%), Gaps = 31/192 (16%)
Query: 24 AECFPACNPQNGFCE---DDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPG---Q 73
+ C P G C + C C+ GW+GP+C Q C P G C + +
Sbjct: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDG-PCV 132
C C G+ G C ++ C S+PCA TCV +G Y C C PG+SG CQ+ G PC+
Sbjct: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEING-YRCVCPPGHSGAKCQEVSGRPCI 864
Query: 133 INGSPCQHGGTCVDD-------EGRASHASCLCPPG-----------FSGNFC-EIVANS 173
GS G DD GR + + C P SG C I+ +
Sbjct: 865 TMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQ 924
Query: 174 CTPNPCENDGVC 185
C +PC G C
Sbjct: 925 CFVHPCTGVGEC 936
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 201 bits (512), Expect = 7e-52
Identities = 94/226 (41%), Positives = 120/226 (53%), Gaps = 8/226 (3%)
Query: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
A C CN +G C CRC GWQG CD+CV PGC+HG C EP QC C W G
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGL 302
Query: 84 LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
LCD+D+ C S PC N GTC++ + Y C+C GYSG++C+K + C N PC +GG
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGG 360
Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
+C + S C CP G+SG C + + C NPC G C D F C CP ++
Sbjct: 361 SCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417
Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
TC V +C CQ+GGTC Y+C+C F G C +R
Sbjct: 418 ATCQLDVNDCRGQ-CQHGGTCKDLVN-GYQCVCPRGFGGRHCELER 461
Score = 154 bits (389), Expect = 1e-37
Identities = 81/213 (38%), Positives = 99/213 (46%), Gaps = 21/213 (9%)
Query: 43 CRCQPGWQGPLCDQCVTSPG-CLHGLCGEPGQCI---------CTDGWDGELCDRDVRAC 92
C C GW+G LCD T+P CL C G+C C DGW G+ C C
Sbjct: 622 CFCPSGWEGELCD---TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 678
Query: 93 SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRA 151
+ C+N GTC D + C+C PG+ G C K+ C+ N PC +GGTCV G
Sbjct: 679 DAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSG 732
Query: 152 SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
+ SC+C G+ G C N C P PC N G+C D FRC C GF C +
Sbjct: 733 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 792
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C SSPC G TC+ Y C C P G C
Sbjct: 793 CQSSPCAYGATCVDEIN-GYRCSCPPGRAGPRC 824
Score = 140 bits (354), Expect = 1e-33
Identities = 84/255 (32%), Positives = 111/255 (43%), Gaps = 43/255 (16%)
Query: 25 ECFPACNPQNGFCED--DNV-CRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPG 72
EC + G CED D C C G+ GPLC D C SP C +G L G+
Sbjct: 463 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP-CRNGARCYNLEGDY- 520
Query: 73 QCICTDGWDGELCDRDVRAC-----------------------SSAPCANNGTCVSLDDG 109
C C D + G+ C C +S C +G CVS G
Sbjct: 521 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 580
Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
+ C C G++G C + C+ G PC++GGTC+D+ C CP G+ G C+
Sbjct: 581 NFSCICDSGFTGTYCHENIDDCL--GQPCRNGGTCIDE---VDAFRCFCPSGWEGELCDT 635
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
N C P+PC + G C D+ DF C C G+ KTC C + C NGGTC
Sbjct: 636 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD- 694
Query: 230 SYECLCKPEFTGLTC 244
++ C C P + G TC
Sbjct: 695 TFRCACPPGWKGSTC 709
Score = 127 bits (319), Expect = 2e-29
Identities = 66/209 (31%), Positives = 93/209 (44%), Gaps = 37/209 (17%)
Query: 65 HGLCGEPGQCICTDGWDGELCDRDV-----------------------------RACSSA 95
H C + G C DGW G+ C V C
Sbjct: 220 HYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPY 279
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
P +G+CV ++C+C + G C K C + PC +GGTC++ E
Sbjct: 280 PGCVHGSCVE----PWQCNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAE--PDQYR 332
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C CP G+SG CE ++CT NPC N G C ++ F C CP+G+ TC+ + CAS+
Sbjct: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
PC GGTC+ +EC+C ++ G TC
Sbjct: 393 PCAAGGTCVDQVD-GFECICPEQWVGATC 420
Score = 114 bits (285), Expect = 1e-25
Identities = 69/213 (32%), Positives = 85/213 (39%), Gaps = 19/213 (8%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QC 74
+C P G C D D C C GW+G C QC G C + G +C
Sbjct: 639 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 698
Query: 75 ICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C GW G C +C PC N GTCV + C C G+ G+ C C
Sbjct: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG-SGASFSCICRDGWEGRTCTHNTNDC-- 755
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
N PC +GG CVD + C C PGF+G C I + C +PC C D +R
Sbjct: 756 NPLPCYNGGICVDG---VNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812
Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
C CP G C + S C + GT H
Sbjct: 813 CSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPH 843
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 198 bits (503), Expect = 8e-51
Identities = 90/222 (40%), Positives = 116/222 (52%), Gaps = 7/222 (3%)
Query: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGE 83
A C CN +G C CRC GWQG CD+CV PGC+HG C EP QC C W G
Sbjct: 243 AVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGL 302
Query: 84 LCDRDVRACSS-APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGG 142
LCD+D+ C S PC N GTC++ + Y C+C GYSG++C+K + C N PC +GG
Sbjct: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGG 360
Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
+C + S C CP G+SG C + + C NPC G C D F C CP ++
Sbjct: 361 SCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417
Query: 203 KTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
TC C PC N +C ++ Y C C P + G+ C
Sbjct: 418 ATCQLDANECEGKPCLNAFSC-KNLIGGYYCDCIPGWKGINC 458
Score = 167 bits (423), Expect = 1e-41
Identities = 82/228 (35%), Positives = 105/228 (46%), Gaps = 15/228 (6%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
C C GW GP C D+C ++P G C + +CIC + W G C D C
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
PC N +C +L G Y C C PG+ G +C C CQHGGTC D +
Sbjct: 431 PCLNAFSCKNLIGGYY-CDCIPGWKGINCHINVNDC---RGQCQHGGTCKD---LVNGYQ 483
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C+CP GF G CE+ + C +PC + G+C D+ F C CP GF C V C S
Sbjct: 484 CVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS 543
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYG 263
PC+NG C + + Y C C +F G C R P R+ G G
Sbjct: 544 PCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 590
Score = 154 bits (389), Expect = 1e-37
Identities = 81/213 (38%), Positives = 99/213 (46%), Gaps = 21/213 (9%)
Query: 43 CRCQPGWQGPLCDQCVTSPG-CLHGLCGEPGQCI---------CTDGWDGELCDRDVRAC 92
C C GW+G LCD T+P CL C G+C C DGW G+ C C
Sbjct: 660 CFCPSGWEGELCD---TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
Query: 93 SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRA 151
+ C+N GTC D + C+C PG+ G C K+ C+ N PC +GGTCV G
Sbjct: 717 DAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSG 770
Query: 152 SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
+ SC+C G+ G C N C P PC N G+C D FRC C GF C +
Sbjct: 771 ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 830
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C SSPC G TC+ Y C C P G C
Sbjct: 831 CQSSPCAYGATCVDEIN-GYRCSCPPGRAGPRC 862
Score = 140 bits (354), Expect = 1e-33
Identities = 84/255 (32%), Positives = 111/255 (43%), Gaps = 43/255 (16%)
Query: 25 ECFPACNPQNGFCED--DNV-CRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPG 72
EC + G CED D C C G+ GPLC D C SP C +G L G+
Sbjct: 501 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP-CRNGARCYNLEGDY- 558
Query: 73 QCICTDGWDGELCDRDVRAC-----------------------SSAPCANNGTCVSLDDG 109
C C D + G+ C C +S C +G CVS G
Sbjct: 559 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
+ C C G++G C + C+ G PC++GGTC+D+ C CP G+ G C+
Sbjct: 619 NFSCICDSGFTGTYCHENIDDCL--GQPCRNGGTCIDE---VDAFRCFCPSGWEGELCDT 673
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
N C P+PC + G C D+ DF C C G+ KTC C + C NGGTC
Sbjct: 674 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD- 732
Query: 230 SYECLCKPEFTGLTC 244
++ C C P + G TC
Sbjct: 733 TFRCACPPGWKGSTC 747
Score = 127 bits (319), Expect = 2e-29
Identities = 66/209 (31%), Positives = 93/209 (44%), Gaps = 37/209 (17%)
Query: 65 HGLCGEPGQCICTDGWDGELCDRDV-----------------------------RACSSA 95
H C + G C DGW G+ C V C
Sbjct: 220 HYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPY 279
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
P +G+CV ++C+C + G C K C + PC +GGTC++ E
Sbjct: 280 PGCVHGSCVE----PWQCNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAE--PDQYR 332
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C CP G+SG CE ++CT NPC N G C ++ F C CP+G+ TC+ + CAS+
Sbjct: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
PC GGTC+ +EC+C ++ G TC
Sbjct: 393 PCAAGGTCVDQVD-GFECICPEQWVGATC 420
Score = 114 bits (285), Expect = 1e-25
Identities = 69/213 (32%), Positives = 85/213 (39%), Gaps = 19/213 (8%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QC 74
+C P G C D D C C GW+G C QC G C + G +C
Sbjct: 677 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736
Query: 75 ICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C GW G C +C PC N GTCV + C C G+ G+ C C
Sbjct: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG-SGASFSCICRDGWEGRTCTHNTNDC-- 793
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFR 193
N PC +GG CVD + C C PGF+G C I + C +PC C D +R
Sbjct: 794 NPLPCYNGGICVDG---VNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 850
Query: 194 CRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
C CP G C + S C + GT H
Sbjct: 851 CSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPH 881
Score = 71.6 bits (174), Expect = 1e-12
Identities = 51/162 (31%), Positives = 67/162 (41%), Gaps = 28/162 (17%)
Query: 94 SAPCANNGTCVSLDD--GLYEC------SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
SA C N C +D G Y C +C G+ GK+C K+ C G HGG V
Sbjct: 204 SATC--NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC--KEAVCK-QGCNLLHGGCTV 258
Query: 146 DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
E C C G+ G FC+ C P P G C + ++C C + C
Sbjct: 259 PGE-------CRCSYGWQGRFCD----ECVPYPGCVHGSCVE---PWQCNCETNWGGLLC 304
Query: 206 SRPVTNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
+ + C S PC NGGTC+ Y C C ++G C K
Sbjct: 305 DKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 168 bits (425), Expect = 9e-42
Identities = 88/235 (37%), Positives = 115/235 (48%), Gaps = 23/235 (9%)
Query: 25 ECFPACNP--QNGFCEDD---NVCRCQPGWQGPLC---------DQCVTSPGCLHGLCGE 70
EC A NP G C DD C C + G C + C + C E
Sbjct: 798 EC--ASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFE 855
Query: 71 PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
C+C GW G+ C D+ C S PC N+G C + G Y C C PG+SG DC++
Sbjct: 856 SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQ-GSYMCECPPGFSGMDCEEDIDD 914
Query: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
C+ N PCQ+GG+C+D + SCLC PGF+G+ C+ N C PC+N G C+D
Sbjct: 915 CLAN--PCQNGGSCMDG---VNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969
Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCV 245
+ C+C AGF C + C S C NGGTC+ S+ CLC FTG C+
Sbjct: 970 SYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGIN-SFSCLCPVGFTGSFCL 1023
Score = 167 bits (422), Expect = 2e-41
Identities = 86/232 (37%), Positives = 115/232 (49%), Gaps = 21/232 (9%)
Query: 25 ECFPACNPQNGFCEDDN---VCRCQPGWQGPLC----DQCVTSP-----GCLHGLCGEPG 72
EC +G C + +C C PG+ G C D C+ +P C+ G+
Sbjct: 876 ECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGV--NTF 933
Query: 73 QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
C+C G+ G+ C D+ C S PC N GTC + Y C C G+ G C+ C
Sbjct: 934 SCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNS-YTCKCQAGFDGVHCENNINECT 992
Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
S C +GGTCVD + SCLCP GF+G+FC N C+ +PC N+G C D G +
Sbjct: 993 --ESSCFNGGTCVDG---INSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTY 1047
Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
RC CP G+ K C V C+ SPC+N GTC+Q S +CLC + G C
Sbjct: 1048 RCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAES-QCLCPSGWAGAYC 1098
Score = 162 bits (410), Expect = 5e-40
Identities = 90/232 (38%), Positives = 114/232 (49%), Gaps = 22/232 (9%)
Query: 27 FPACNPQNGFCEDDNV---CRCQPGWQGPLC---DQCVTSPGCLHGLCGEP---GQCICT 77
F +C P C D C C G G LC D C+++P LC GQ ICT
Sbjct: 344 FASCTP-GSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICT 402
Query: 78 --DGWDGELCDRDVRACSSA---PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
G+ G C DV C+ A PC + G CV+ D G + C C GY+G C+ C
Sbjct: 403 CPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC- 460
Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
+ PCQ+ TC+D G + CLC PGF G CE+ N C NPC N+G C D F
Sbjct: 461 -HSDPCQNDATCLDKIGGFT---CLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516
Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+C CP GF C + +C+S+PC NG C+ H YEC C FTG+ C
Sbjct: 517 QCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPN-GYECQCATGFTGVLC 567
Score = 159 bits (402), Expect = 4e-39
Identities = 92/266 (34%), Positives = 121/266 (45%), Gaps = 57/266 (21%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLC--GEPG-QCI 75
GA C N NGF C C G P C ++C+++P C+HG C G G +C+
Sbjct: 694 GATCI---NGVNGFR-----CICPEGPHHPSCYSQVNECLSNP-CIHGNCTGGLSGYKCL 744
Query: 76 CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
C GW G C+ D C S PC N GTC +L +G Y C+C G+ G +CQ C N
Sbjct: 745 CDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNG-YRCTCKKGFKGYNCQVNIDECASN- 802
Query: 136 SPCQHGGTCVDD-EGRASHA------------------------------------SCLC 158
PC + GTC DD G H +CLC
Sbjct: 803 -PCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLC 861
Query: 159 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
PG+ G C I + C PC N G+C + G + C CP GF C + +C ++PCQ
Sbjct: 862 APGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQ 921
Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTC 244
NGG+C+ ++ CLC P FTG C
Sbjct: 922 NGGSCMDGVN-TFSCLCLPGFTGDKC 946
Score = 152 bits (384), Expect = 5e-37
Identities = 87/254 (34%), Positives = 116/254 (45%), Gaps = 22/254 (8%)
Query: 6 ALLRVLLLLLAFGHSTYGAECFPACNPQNGFC----EDDNVCRCQPGWQGPLC------- 54
ALL + L A H+ + + C G C C+C G+ G C
Sbjct: 11 ALLALWLCCAAPAHALQCRDGYEPC-VNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCE 69
Query: 55 -DQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVR--ACSSAPCANNGTCVSLDDGLY 111
++C C+ C C G+ GE C S PC N GTC L Y
Sbjct: 70 KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTY 129
Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
EC+C G++GK+CQ D C+ + PC +G TC A+ SC C GF+G CE
Sbjct: 130 ECTCQVGFTGKECQWTDA-CLSH--PCANGSTCTTV---ANQFSCKCLTGFTGQKCETDV 183
Query: 172 NSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVS 230
N C P C++ G C ++ G ++C+CP GF + C CA SPC NGGTC Q +
Sbjct: 184 NECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT 243
Query: 231 YECLCKPEFTGLTC 244
+EC C P F G TC
Sbjct: 244 FECNCLPGFEGSTC 257
Score = 152 bits (384), Expect = 5e-37
Identities = 79/215 (36%), Positives = 108/215 (50%), Gaps = 18/215 (8%)
Query: 43 CRCQPGWQGPLCDQ-----CVTSPGCLHG-----LCGEPGQCICTDGWDGELCDRDVRAC 92
CRC G+ G C C S CL+G L + +C C G+ G+ C AC
Sbjct: 90 CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC 148
Query: 93 SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
S PCAN TC ++ + + C C G++G+ C+ C I G CQHGGTC++ G
Sbjct: 149 LSHPCANGSTCTTVANQ-FSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLNLPGSYQ 206
Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPVTN 211
C CP GF+G +C+ + C P+PC N G C G F C C GF TC R + +
Sbjct: 207 ---CQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDD 263
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
C + CQNGG C+ +Y C C P++TG C +
Sbjct: 264 CPNHRCQNGGVCVDGVN-TYNCRCPPQWTGQFCTE 297
Score = 151 bits (382), Expect = 8e-37
Identities = 80/230 (34%), Positives = 110/230 (47%), Gaps = 19/230 (8%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEP---GQC 74
EC+ + +G C D C CQPG G C D C ++P C+HG+C + C
Sbjct: 610 ECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNP-CIHGICMDGINRYSC 668
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
+C+ G+ G+ C+ D+ C+S PC TC++ +G + C C G C + C+ N
Sbjct: 669 VCSPGFTGQRCNIDIDECASNPCRKGATCINGVNG-FRCICPEGPHHPSCYSQVNECLSN 727
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
PC HG G S CLC G+ G CE+ N C NPC+N G C ++ +RC
Sbjct: 728 --PCIHGNCT----GGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRC 781
Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C GF C + CAS+PC N GTC Y C C +TG C
Sbjct: 782 TCKKGFKGYNCQVNIDECASNPCLNQGTCFDDIS-GYTCHCVLPYTGKNC 830
Score = 151 bits (381), Expect = 1e-36
Identities = 87/277 (31%), Positives = 118/277 (42%), Gaps = 63/277 (22%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLCDQCV---TSPGCLHGLCGEPG----QC 74
EC G C D C+CQ G+ G C+ + T C +G G C
Sbjct: 952 ECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC 1011
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCV 132
+C G+ G C ++ CSS PC N GTCV DGL Y CSC GY+GK+CQ C
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCV---DGLGTYRCSCPLGYTGKNCQTLVNLC- 1067
Query: 133 INGSPCQHGGTCVDDEGRAS-----------------------------------HAS-- 155
+ SPC++ GTCV + + H+
Sbjct: 1068 -SRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVC 1126
Query: 156 --------CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
C CP G++G++CE + C NPC++ C+D G +RC C G+ C
Sbjct: 1127 INAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEY 1186
Query: 208 PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
V C + PCQNGGTC+ ++C C P GL C
Sbjct: 1187 EVDECQNQPCQNGGTCIDLVN-HFKCSCPPGTRGLLC 1222
Score = 148 bits (374), Expect = 7e-36
Identities = 82/236 (34%), Positives = 108/236 (45%), Gaps = 31/236 (13%)
Query: 40 DNVCRCQPGWQGPLCDQCVTSPGC----------LHGLCGEPGQCI---------CTDGW 80
++ C C GW G CD V + C + LC G CI C G+
Sbjct: 1084 ESQCLCPSGWAGAYCD--VPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY 1141
Query: 81 DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
G C+ + C+S PC + TC G Y C C PGY G +C+ + C PCQ+
Sbjct: 1142 TGSYCEEQLDECASNPCQHGATCSDFIGG-YRCECVPGYQGVNCEYEVDEC--QNQPCQN 1198
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-CENDGVCTDIGGDFRCRCPAG 199
GGTC+D +H C CPPG G CE + C P C N G C D G + CRC G
Sbjct: 1199 GGTCID---LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPG 1255
Query: 200 FIDKTCSRPVTNCASSPCQNGGT--CLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
F + C + C S+PC + G+ C+Q T Y C+C+ FTG C + PQ
Sbjct: 1256 FAGERCEGDINECLSNPCSSEGSLDCIQLTN-DYLCVCRSAFTGRHCETFVDVCPQ 1310
Score = 146 bits (368), Expect = 3e-35
Identities = 78/224 (34%), Positives = 104/224 (46%), Gaps = 22/224 (9%)
Query: 31 NPQNGFCEDDNVCRCQPGWQGPLC----DQCV--TSPGCLH-GLCGEPG---QCICTDGW 80
NP NG +C C G++G C D+C S C H G C C C G+
Sbjct: 393 NPLNG----QYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY 448
Query: 81 DGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
G C+ D+ C S PC N+ TC+ G + C C PG+ G C+ + C N PC +
Sbjct: 449 AGPRCEMDINECHSDPCQNDATCLDKIGG-FTCLCMPGFKGVHCELEINECQSN--PCVN 505
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF 200
G CVD + + CLCPPGF+G C+I + C+ PC N C D + C+C GF
Sbjct: 506 NGQCVD---KVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGF 562
Query: 201 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C + NC PC +G Q SY C+C P + G C
Sbjct: 563 TGVLCEENIDNCDPDPCHHGQ--CQDGIDSYTCICNPGYMGAIC 604
Score = 145 bits (367), Expect = 5e-35
Identities = 75/212 (35%), Positives = 103/212 (48%), Gaps = 16/212 (7%)
Query: 43 CRCQPGWQGPLCDQCVTS---PG-CLHG--LCGEPG--QCICTDGWDGELCDRDVRACSS 94
C+C G+ G C+ V PG C HG PG QC C G+ G+ CD C+
Sbjct: 168 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAP 227
Query: 95 APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
+PC N GTC D +EC+C PG+ G C++ C CQ+GG CVD +
Sbjct: 228 SPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDC--PNHRCQNGGVCVDG---VNTY 282
Query: 155 SCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
+C CPP ++G FC + C PN C+N G C + G + C C G+ CS + +C
Sbjct: 283 NCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDC 342
Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
A + C G TC+ S+ C+C GL C
Sbjct: 343 AFASCTPGSTCIDRV-ASFSCMCPEGKAGLLC 373
Score = 144 bits (363), Expect = 1e-34
Identities = 77/214 (35%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGL-CGE---PGQCICTDGWDGELCDRDVRACSS 94
C+C G+ G C D+C ++P C HG C + +C C G+ G C+ +V C +
Sbjct: 1135 CQCPLGYTGSYCEEQLDECASNP-CQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQN 1193
Query: 95 APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
PC N GTC+ L + ++CSC PG G C++ C G C +GG C+D R
Sbjct: 1194 QPCQNGGTCIDLVNH-FKCSCPPGTRGLLCEENIDDCA-RGPHCLNGGQCMD---RIGGY 1248
Query: 155 SCLCPPGFSGNFCEIVANSCTPNPCENDGV--CTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
SC C PGF+G CE N C NPC ++G C + D+ C C + F + C V C
Sbjct: 1249 SCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVC 1308
Query: 213 ASSPCQNGGTCLQHTQV--SYECLCKPEFTGLTC 244
PC NGGTC + + + C C P F+G C
Sbjct: 1309 PQMPCLNGGTCAVASNMPDGFICRCPPGFSGARC 1342
Score = 143 bits (361), Expect = 2e-34
Identities = 75/209 (35%), Positives = 108/209 (51%), Gaps = 16/209 (7%)
Query: 43 CRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
C C PG++G C+ +C ++P +G C + QC+C G+ G +C D+ CSS
Sbjct: 480 CLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSST 539
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
PC N C+ +G YEC CA G++G C++ C + PC HG C D G S+ +
Sbjct: 540 PCLNGAKCIDHPNG-YECQCATGFTGVLCEENIDNC--DPDPCHHG-QCQD--GIDSY-T 592
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C+C PG+ G C + C +PC NDG C D+ ++C C G C +CAS+
Sbjct: 593 CICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASN 652
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
PC + G C+ Y C+C P FTG C
Sbjct: 653 PCIH-GICMDGIN-RYSCVCSPGFTGQRC 679
Score = 137 bits (344), Expect = 2e-32
Identities = 76/220 (34%), Positives = 97/220 (44%), Gaps = 25/220 (11%)
Query: 43 CRCQPGWQGPLCDQ----CVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSA 95
C C G+ G C C SP G C + QC+C GW G CD +C A
Sbjct: 1049 CSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIA 1108
Query: 96 P----------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
C ++G C++ + Y C C GY+G C+++ C N PCQHG TC
Sbjct: 1109 ASRRGVLVEHLCQHSGVCINAGNTHY-CQCPLGYTGSYCEEQLDECASN--PCQHGATCS 1165
Query: 146 DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
D G C C PG+ G CE + C PC+N G C D+ F+C CP G C
Sbjct: 1166 DFIGGYR---CECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLC 1222
Query: 206 SRPVTNCASSP-CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ +CA P C NGG C+ Y C C P F G C
Sbjct: 1223 EENIDDCARGPHCLNGGQCMDRIG-GYSCRCLPGFAGERC 1261
Score = 130 bits (328), Expect = 2e-30
Identities = 77/218 (35%), Positives = 101/218 (46%), Gaps = 33/218 (15%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQCI---------CTDGWDGELCDRDV 89
C C PG +G LC D C P CL+G GQC+ C G+ GE C+ D+
Sbjct: 1211 CSCPPGTRGLLCEENIDDCARGPHCLNG-----GQCMDRIGGYSCRCLPGFAGERCEGDI 1265
Query: 90 RACSSAPCANNGT--CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD 147
C S PC++ G+ C+ L + Y C C ++G+ C+ C PC +GGTC
Sbjct: 1266 NECLSNPCSSEGSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCP--QMPCLNGGTCAVA 1322
Query: 148 EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
C CPPGFSG C+ +SC C C RC CP+ + C
Sbjct: 1323 SNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPS---PRDCE- 1375
Query: 208 PVTNCASSPCQNGGTCLQHTQVS-YECLCKPEFTGLTC 244
+ CASSPCQ+GG+C Q Y C C P F+G C
Sbjct: 1376 --SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRC 1411
Score = 67.0 bits (162), Expect = 3e-11
Identities = 54/203 (26%), Positives = 71/203 (34%), Gaps = 54/203 (26%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD------QCVTSPGCLHGLCGEPGQCIC 76
G C A N +GF +CRC PG+ G C +C C+H G +C C
Sbjct: 1316 GGTCAVASNMPDGF-----ICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGP--RCFC 1368
Query: 77 TDGWDGELCDRDVRACSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
D E C+S+PC + G+C Y C CAP +SG C+ P
Sbjct: 1369 PSPRDCE------SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAP----- 1417
Query: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCR 195
P TC+ +C A DGVC + C+
Sbjct: 1418 -PSTPPATCL------------------SQYCADKA---------RDGVCDEACNSHACQ 1449
Query: 196 CPAGFIDKTCSRPVTNCASS-PC 217
G T P NC+S PC
Sbjct: 1450 WDGGDCSLTMENPWANCSSPLPC 1472
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 162 bits (410), Expect = 5e-40
Identities = 78/221 (35%), Positives = 110/221 (49%), Gaps = 15/221 (6%)
Query: 34 NGFCEDD---NVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ---CICTDGWDGE 83
+G C D C C PGW G CD +C ++P G C + C C +G+ G
Sbjct: 727 HGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGP 786
Query: 84 LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
C ++ C+S PC N GTC+ D Y+C+C Y+G C+ PC SPC++GG
Sbjct: 787 NCQTNINECASNPCLNQGTCID-DVAGYKCNCLLPYTGATCEVVLAPCA--PSPCRNGGE 843
Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
C E S SC+CP G+ G CE+ N C +PC + C + G +RC C AG+ +
Sbjct: 844 CRQSEDYESF-SCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGR 902
Query: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C + +C +PC NGG+C ++ C C P F G C
Sbjct: 903 NCETDIDDCRPNPCHNGGSCTDGINTAF-CDCLPGFRGTFC 942
Score = 162 bits (409), Expect = 6e-40
Identities = 89/234 (38%), Positives = 110/234 (47%), Gaps = 23/234 (9%)
Query: 25 ECFPACNP--QNGFCEDDNV---CRCQPGWQGPLCD----QCVTSPGCLHGLCG-----E 70
EC A NP G C DD C C + G C+ C SP G C E
Sbjct: 794 EC--ASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYE 851
Query: 71 PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
C+C GW G+ C+ D+ C +PC + +C + G Y C C GYSG++C+
Sbjct: 852 SFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGG-YRCHCQAGYSGRNCETDIDD 910
Query: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
C N PC +GG+C D + A C C PGF G FCE N C +PC N CTD
Sbjct: 911 CRPN--PCHNGGSCTDG---INTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVD 965
Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C CPAGF C +C S C NGGTC+ S+ CLC P FTG C
Sbjct: 966 SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGIN-SFTCLCPPGFTGSYC 1018
Score = 157 bits (397), Expect = 2e-38
Identities = 84/239 (35%), Positives = 113/239 (47%), Gaps = 25/239 (10%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG----Q 73
+C + G C D C C PG+ G C ++C + P CLHG + G +
Sbjct: 986 DCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP-CLHGGTCQDGCGSYR 1044
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C C G+ G C V C S+PC N G C Y C C G++G C C +
Sbjct: 1045 CTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQ-YRCECPSGWTGLYCDVPSVSCEV 1103
Query: 134 NGSP--------CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
CQHGG CVD G H C C G++G++CE + + C+P+PC+N C
Sbjct: 1104 AAQRQGVDVARLCQHGGLCVD-AGNTHH--CRCQAGYTGSYCEDLVDECSPSPCQNGATC 1160
Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
TD G + C+C AG+ CS + C S PCQNGGTCL +Y+C C G+ C
Sbjct: 1161 TDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPN-TYKCSCPRGTQGVHC 1218
Score = 155 bits (391), Expect = 7e-38
Identities = 81/234 (34%), Positives = 116/234 (49%), Gaps = 27/234 (11%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG---------Q 73
G +C P E +C C P + GP C Q V G GLC G +
Sbjct: 152 GGQCLPF--------EASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYR 203
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C+C G C+R CS +PC N GTC D +EC+C PG++G++C++ C
Sbjct: 204 CVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDC-- 261
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGD 191
G+ C++GG CVD + +C CPP ++G +C + C PN C+N G C + G
Sbjct: 262 PGNNCKNGGACVDG---VNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGG 318
Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
+ C C G+ + CS + +CAS+ C +G TC H +V S+ C C TGL C
Sbjct: 319 YNCVCVNGWTGEDCSENIDDCASAACFHGATC--HDRVASFYCECPHGRTGLLC 370
Score = 154 bits (390), Expect = 1e-37
Identities = 90/226 (39%), Positives = 110/226 (48%), Gaps = 22/226 (9%)
Query: 35 GFCEDDN---VCRCQPGWQGPLCDQ---CVTSPGCLHGLCGEPGQ-------CICTDGWD 81
G CE N C C + GP C C+++P G C + C C G+
Sbjct: 35 GKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFS 94
Query: 82 GELCDRDV-RACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
G LC + AC + PC N GTC L Y+C C PG+SGK CQ+ D PC N PC +
Sbjct: 95 GPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQAD-PCASN--PCAN 151
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP--CENDGVCTDIGGDFRCRCPA 198
GG C+ E AS+ C CPP F G C N C P C + G C + G +RC C A
Sbjct: 152 GGQCLPFE--ASYI-CHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208
Query: 199 GFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C RP C+ SPCQNGGTC V++EC C P FTG C
Sbjct: 209 THTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNC 254
Score = 152 bits (383), Expect = 6e-37
Identities = 77/212 (36%), Positives = 105/212 (49%), Gaps = 17/212 (8%)
Query: 43 CRCQPGWQGPLC---DQCVTSP-----GCLHGLCGEPGQCICTDGWDGELCDRDVRACS- 93
C C G G LC D C+++P C C C G+ G C +DV CS
Sbjct: 359 CECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSL 418
Query: 94 -SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
+ PC + G C++ G +EC C GY+G C+ CV N PCQ+ TC+D G
Sbjct: 419 GANPCEHAGKCINTL-GSFECQCLQGYTGPRCEIDVNECVSN--PCQNDATCLDQIGEFQ 475
Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
C+C PG+ G CE+ + C +PC ++G C D +F+C CP GF C V C
Sbjct: 476 ---CICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDEC 532
Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
AS+PC+NG CL +Y C+C +TG C
Sbjct: 533 ASTPCKNGAKCLDGPN-TYTCVCTEGYTGTHC 563
Score = 152 bits (383), Expect = 6e-37
Identities = 85/236 (36%), Positives = 104/236 (44%), Gaps = 25/236 (10%)
Query: 24 AECFPACNPQNGFCEDDN-----VCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPG-- 72
A C P+ G C C C GWQG C+ +CV SP C HG +
Sbjct: 831 APCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSP-CRHGASCQNTHG 889
Query: 73 --QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE--CSCAPGYSGKDCQKKD 128
+C C G+ G C+ D+ C PC N G+C DG+ C C PG+ G C++
Sbjct: 890 GYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCT---DGINTAFCDCLPGFRGTFCEEDI 946
Query: 129 GPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI 188
C PC++G C D +C CP GFSG CE CT + C N G C D
Sbjct: 947 NECA--SDPCRNGANCTDC---VDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDG 1001
Query: 189 GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
F C CP GF C V C S PC +GGTC Q SY C C +TG C
Sbjct: 1002 INSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTC-QDGCGSYRCTCPQGYTGPNC 1056
Score = 145 bits (367), Expect = 5e-35
Identities = 79/229 (34%), Positives = 108/229 (47%), Gaps = 25/229 (10%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCI 75
GA+C N C C G+ G C D+C P C +G C + C+
Sbjct: 540 GAKCLDGPNTYT--------CVCTEGYTGTHCEVDIDECDPDP-CHYGSCKDGVATFTCL 590
Query: 76 CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
C G+ G C+ ++ CSS PC + GTC D+ Y C C G +G +C+ C
Sbjct: 591 CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNA-YLCFCLKGTTGPNCEINLDDCA--S 647
Query: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCR 195
SPC GTC+D + C C PG++G+ C I + C NPC N G C D F CR
Sbjct: 648 SPCD-SGTCLD---KIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCR 703
Query: 196 CPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
CP G+ D TC V C S+PC +G + + Y+C C P ++G C
Sbjct: 704 CPEGYHDPTCLSEVNECNSNPCVHG--ACRDSLNGYKCDCDPGWSGTNC 750
Score = 144 bits (364), Expect = 1e-34
Identities = 73/223 (32%), Positives = 99/223 (44%), Gaps = 21/223 (9%)
Query: 31 NPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI---------CTDGWD 81
NP NG +C C G+ GP C Q V C G+CI C G+
Sbjct: 390 NPVNGKA----ICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYT 445
Query: 82 GELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHG 141
G C+ DV C S PC N+ TC+ G ++C C PGY G C+ C SPC H
Sbjct: 446 GPRCEIDVNECVSNPCQNDATCLD-QIGEFQCICMPGYEGVHCEVNTDECA--SSPCLHN 502
Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFI 201
G C+D + + C CP GF+G+ C+ + C PC+N C D + C C G+
Sbjct: 503 GRCLD---KINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYT 559
Query: 202 DKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C + C PC G + ++ CLC+P +TG C
Sbjct: 560 GTHCEVDIDECDPDPCHYGS--CKDGVATFTCLCRPGYTGHHC 600
Score = 142 bits (357), Expect = 7e-34
Identities = 73/217 (33%), Positives = 103/217 (47%), Gaps = 16/217 (7%)
Query: 40 DNVCRCQPGWQGPLC-----DQCVTSPGCLHGLCG----EPGQCICTDGWDGELCDRDVR 90
D C C G+ GPLC + C+T+P G C +C C GW G+ C +
Sbjct: 84 DYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ-AD 142
Query: 91 ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGR 150
C+S PCAN G C+ + Y C C P + G C++ C C+HGGTC ++ G
Sbjct: 143 PCASNPCANGGQCLPFEAS-YICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGS 201
Query: 151 ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPV 209
C+C +G CE C+P+PC+N G C G C C GF + C +
Sbjct: 202 YR---CVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENI 258
Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
+C + C+NGG C+ +Y C C PE+TG C +
Sbjct: 259 DDCPGNNCKNGGACVDGVN-TYNCRCPPEWTGQYCTE 294
Score = 120 bits (301), Expect = 2e-27
Identities = 82/244 (33%), Positives = 100/244 (40%), Gaps = 28/244 (11%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC-----------DQCVTSPGCLH-GLCG 69
EC G C D C C G QG C D SP C + G C
Sbjct: 1186 ECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCV 1245
Query: 70 EPG---QCICTDGWDGELCDRDVRACSSAPCANNGT--CVSLDDGLYECSCAPGYSGKDC 124
+ C C G+ GE C+ DV C S PC GT CV + + C C G++G+ C
Sbjct: 1246 DQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVND-FHCECRAGHTGRRC 1304
Query: 125 QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGV 184
+ C G PC++GGTC A C CP GF G CE A +C C N G
Sbjct: 1305 ESVINGC--KGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGT 1362
Query: 185 CTDIGGDFRCRCPAGFIDKTCSRPVTN--CASSPCQNGGTCLQHTQVS--YECLCKPEFT 240
C C C F C P ++ +PC N GTC + T S Y CLC +F
Sbjct: 1363 CISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTC-EPTSESPFYRCLCPAKFN 1421
Query: 241 GLTC 244
GL C
Sbjct: 1422 GLLC 1425
Score = 82.8 bits (203), Expect = 5e-16
Identities = 57/210 (27%), Positives = 80/210 (38%), Gaps = 38/210 (18%)
Query: 39 DDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI------------CTDGWDGELCD 86
+D C C+ G G C+ + GC C G C C G++G C+
Sbjct: 1289 NDFHCECRAGHTGRRCESVIN--GCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCE 1346
Query: 87 RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCV 145
D R C S C N GTC+S C C ++G +CQ PC + G+PC + GTC
Sbjct: 1347 NDARTCGSLRCLNGGTCIS-GPRSPTCLCLGPFTGPECQFPASSPC-LGGNPCYNQGTC- 1403
Query: 146 DDEGRASHASCLCPPGFSGNFCEI-----------------VANSCTPNPCENDG---VC 185
+ + CLCP F+G C I + +C C+ D VC
Sbjct: 1404 EPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVC 1463
Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
+ + C G + P NC S
Sbjct: 1464 SLQCNNHACGWDGGDCSLNFNDPWKNCTQS 1493
Score = 47.4 bits (111), Expect = 2e-05
Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 4/70 (5%)
Query: 179 CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL---QHTQVSYECLC 235
C N G C G C C F+ C P C S+PC+N GTC + Y C C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQDP-NPCLSTPCKNAGTCHVVDRRGVADYACSC 89
Query: 236 KPEFTGLTCV 245
F+G C+
Sbjct: 90 ALGFSGPLCL 99
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 160 bits (404), Expect = 2e-39
Identities = 88/268 (32%), Positives = 117/268 (43%), Gaps = 42/268 (15%)
Query: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-------------------- 65
C C+P++GFCE CRC GW GPLC V++ CL
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 66 -------GLCGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCV--SLDDGLYEC 113
G C E +C C G+ G C+ C+ PC N G CV + D Y C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 114 SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEIVAN 172
C PG+ G +C+K+ C + PC++GG C+D HA C C GF+G CE +
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQ--PCRNGGLCLD----LGHALRCRCRAGFAGPRCEHDLD 393
Query: 173 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
C C N G C + GG RC C GF + C CA+ PC +GG C H
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS-GLV 452
Query: 233 CLCKPEFTGLTCVKKRALSPQQVTRLPS 260
C C P + G C + + P + LP+
Sbjct: 453 CACAPGYMGARC--EFPVHPDGASALPA 478
Score = 154 bits (390), Expect = 1e-37
Identities = 88/253 (34%), Positives = 112/253 (44%), Gaps = 41/253 (16%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQ--GPLCDQC----VTSPGCL--HGLCGEPGQC 74
G C C P++ RC PG + PL D+C V GC HG C +PG+C
Sbjct: 184 GTACTRLCRPRSA------PSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGEC 237
Query: 75 ICTDGWDGELCDRDVRA-----------------------CSSAPCANNGTCVSLDDGLY 111
C +GW G LC V C PCAN G+C S +
Sbjct: 238 RCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC-SETPRSF 296
Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
EC+C G+ G C+ C PC +GG CV S C CPPGF G+ CE
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCA--DGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
+ C+ PC N G+C D+G RCRC AGF C + +CA C NGGTC++ ++
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG-AH 413
Query: 232 ECLCKPEFTGLTC 244
C C F G C
Sbjct: 414 RCSCALGFGGRDC 426
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 160 bits (404), Expect = 2e-39
Identities = 88/268 (32%), Positives = 117/268 (43%), Gaps = 42/268 (15%)
Query: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-------------------- 65
C C+P++GFCE CRC GW GPLC V++ CL
Sbjct: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
Query: 66 -------GLCGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCV--SLDDGLYEC 113
G C E +C C G+ G C+ C+ PC N G CV + D Y C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 114 SCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEIVAN 172
C PG+ G +C+K+ C + PC++GG C+D HA C C GF+G CE +
Sbjct: 340 HCPPGFQGSNCEKRVDRCSLQ--PCRNGGLCLD----LGHALRCRCRAGFAGPRCEHDLD 393
Query: 173 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
C C N G C + GG RC C GF + C CA+ PC +GG C H
Sbjct: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS-GLV 452
Query: 233 CLCKPEFTGLTCVKKRALSPQQVTRLPS 260
C C P + G C + + P + LP+
Sbjct: 453 CACAPGYMGARC--EFPVHPDGASALPA 478
Score = 154 bits (390), Expect = 1e-37
Identities = 88/253 (34%), Positives = 112/253 (44%), Gaps = 41/253 (16%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQ--GPLCDQC----VTSPGCL--HGLCGEPGQC 74
G C C P++ RC PG + PL D+C V GC HG C +PG+C
Sbjct: 184 GTACTRLCRPRSA------PSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGEC 237
Query: 75 ICTDGWDGELCDRDVRA-----------------------CSSAPCANNGTCVSLDDGLY 111
C +GW G LC V C PCAN G+C S +
Sbjct: 238 RCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC-SETPRSF 296
Query: 112 ECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
EC+C G+ G C+ C PC +GG CV S C CPPGF G+ CE
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCA--DGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
+ C+ PC N G+C D+G RCRC AGF C + +CA C NGGTC++ ++
Sbjct: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG-AH 413
Query: 232 ECLCKPEFTGLTC 244
C C F G C
Sbjct: 414 RCSCALGFGGRDC 426
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 158 bits (400), Expect = 7e-39
Identities = 87/236 (36%), Positives = 117/236 (49%), Gaps = 23/236 (9%)
Query: 25 ECFPACNPQNGFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PG--QC 74
EC + + G C D C C PG PLC C P C HG+C + PG +C
Sbjct: 660 ECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEP-CSHGICYDAPGGFRC 718
Query: 75 ICTDGWDGELCDRDVR--ACSSAPCANNGTCVSLDDGL-YECSCAPGYSGKDCQKKDGPC 131
+C GW G C + + AC S PC GTC S DG+ + C+C PG G+ C+ PC
Sbjct: 719 VCEPGWSGPRCSQSLARDACESQPCRAGGTCSS--DGMGFHCTCPPGVQGRQCELLS-PC 775
Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT-PNPCENDGVCTDIGG 190
N PC+HGG C G+ C CP G+ G C+ + C P PC G+CT++ G
Sbjct: 776 TPN--PCEHGGRCESAPGQLP--VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAG 831
Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
F C C G+ +C + + +C +PC NGG+C Q S+ C C P F G C +
Sbjct: 832 SFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPRCAR 886
Score = 155 bits (392), Expect = 6e-38
Identities = 88/251 (35%), Positives = 111/251 (44%), Gaps = 22/251 (8%)
Query: 12 LLLLAFGHSTYGAECFPACNPQNG-----FCEDDNVCRCQPGWQGPLC---DQCVTSPGC 63
LLLL G C NG + C C PGW G C D C + P
Sbjct: 29 LLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCA 88
Query: 64 LHGLCGEPG-------QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA 116
G+C C C G+ G C C S+PCA+ C DG + CSC
Sbjct: 89 GRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCP 147
Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
PGY G+ C+ C + G PC+HGGTC++ G C CP G++G CE A C P
Sbjct: 148 PGYQGRSCRSDVDECRV-GEPCRHGGTCLNTPGSFR---CQCPAGYTGPLCENPAVPCAP 203
Query: 177 NPCENDGVCTDIGG-DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
+PC N G C G + C C GF + C V +C C NGGTC+ +Y C C
Sbjct: 204 SPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN-TYNCQC 262
Query: 236 KPEFTGLTCVK 246
PE+TG C +
Sbjct: 263 PPEWTGQFCTE 273
Score = 154 bits (389), Expect = 1e-37
Identities = 81/212 (38%), Positives = 108/212 (50%), Gaps = 17/212 (8%)
Query: 43 CRCQPGWQGPLC---DQCVTSPGCLHGLCGEP---GQCICT--DGWDGELCDRDVRACS- 93
C C G G LC D CV++P +C G+ ICT G+ G CD+DV CS
Sbjct: 338 CACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSI 397
Query: 94 -SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
+ PC + G CV+ G + C C GY+G C+ C+ PC++ TC+D R
Sbjct: 398 GANPCEHLGRCVNTQ-GSFLCQCGRGYTGPRCETDVNECL--SGPCRNQATCLD---RIG 451
Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC 212
+C+C GF+G +CE+ + C +PC N GVC D F C CP+GF TC V C
Sbjct: 452 QFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC 511
Query: 213 ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
AS+PC+NG C+ YEC C F G C
Sbjct: 512 ASTPCRNGAKCVDQPD-GYECRCAEGFEGTLC 542
Score = 153 bits (387), Expect = 2e-37
Identities = 84/234 (35%), Positives = 118/234 (50%), Gaps = 25/234 (10%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHG--LCGEPG--Q 73
+GA C + P F +C C PG+QG C D+C C HG PG +
Sbjct: 130 HGARC--SVGPDGRF-----LCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFR 182
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C C G+ G LC+ C+ +PC N GTC D Y+C+C PG+ G++C+ C
Sbjct: 183 CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDC-- 240
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGD 191
G C +GGTCVD + +C CPP ++G FC + C PN C N G C + G
Sbjct: 241 PGHRCLNGGTCVDG---VNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGG 297
Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
C C G+ ++CS+ + +CA++ C +G TC H +V S+ C C TGL C
Sbjct: 298 HSCVCVNGWTGESCSQNIDDCATAVCFHGATC--HDRVASFYCACPMGKTGLLC 349
Score = 150 bits (380), Expect = 1e-36
Identities = 79/223 (35%), Positives = 103/223 (46%), Gaps = 21/223 (9%)
Query: 31 NPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCI---------CTDGWD 81
NP NG +C C PG+ G CDQ V C G+C+ C G+
Sbjct: 369 NPVNGRA----ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYT 424
Query: 82 GELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHG 141
G C+ DV C S PC N TC+ G + C C G++G C+ C SPC +G
Sbjct: 425 GPRCETDVNECLSGPCRNQATCLDRI-GQFTCICMAGFTGTYCEVDIDEC--QSSPCVNG 481
Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFI 201
G C D R + SC CP GFSG+ C++ + C PC N C D + CRC GF
Sbjct: 482 GVCKD---RVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE 538
Query: 202 DKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C R V +C+ PC + G C+ S+ C C P +TG C
Sbjct: 539 GTLCDRNVDDCSPDPCHH-GRCVDGI-ASFSCACAPGYTGTRC 579
Score = 150 bits (379), Expect = 2e-36
Identities = 88/266 (33%), Positives = 111/266 (41%), Gaps = 54/266 (20%)
Query: 26 CFPACNPQNGFCEDDN----VCRCQPGWQGPLC----DQCVTSPGC-LHGLCGEPG---Q 73
C P G CE VC C GWQGP C D+C C HG+C
Sbjct: 775 CTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFS 834
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C C G+ G CD+D+ C PC N G+C G + CSC PG++G C + C+
Sbjct: 835 CTCHGGYTGPSCDQDINDCDPNPCLNGGSCQD-GVGSFSCSCLPGFAGPRCARDVDECLS 893
Query: 134 NG-----------------------------------SPCQHGGTCVDDEGRASHASCLC 158
N S C +GGTCVD + SCLC
Sbjct: 894 NPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDG---VNSFSCLC 950
Query: 159 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
PG++G C+ A+ C PC + GVC+ FRC C F C V C+ PCQ
Sbjct: 951 RPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQ 1010
Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTC 244
NGG C+ Q CLC P ++G C
Sbjct: 1011 NGGRCV---QTGAYCLCPPGWSGRLC 1033
Score = 149 bits (377), Expect = 3e-36
Identities = 88/239 (36%), Positives = 116/239 (48%), Gaps = 27/239 (11%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHG-LCG--EPG-Q 73
+C P+ G C D C C+PG+ G C D C++ P CLHG +C PG +
Sbjct: 927 DCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRP-CLHGGVCSAAHPGFR 985
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC-- 131
C C + + G C V CS PC N G CV G Y C C PG+SG+ C + PC
Sbjct: 986 CTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAY-CLCPPGWSGRLCDIRSLPCRE 1042
Query: 132 ------VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVC 185
V CQ GG CVD++ +SH C+CP G +G+ CE + C PC++ G C
Sbjct: 1043 AAAQIGVRLEQLCQAGGQCVDED--SSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTC 1099
Query: 186 TDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
G + C C G+ C V CAS PCQ+GG+C+ Y C C P G+ C
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCID-LVARYLCSCPPGTLGVLC 1157
Score = 140 bits (353), Expect = 2e-33
Identities = 84/272 (30%), Positives = 123/272 (45%), Gaps = 56/272 (20%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGL--CGEPG--Q 73
EC + G C+D C C G+ G C D+C ++P C +G +P +
Sbjct: 472 ECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTP-CRNGAKCVDQPDGYE 530
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPC 131
C C +G++G LCDR+V CS PC ++G CV DG+ + C+CAPGY+G C+ + C
Sbjct: 531 CRCAEGFEGTLCDRNVDDCSPDPC-HHGRCV---DGIASFSCACAPGYTGTRCESQVDEC 586
Query: 132 VINGSPCQHGGTCVD----------------------DEGRASHAS------------CL 157
PC+HGG C+D D+ ++ + C+
Sbjct: 587 --RSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCV 644
Query: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
C PGF+G C + N C +PC G C D FRC CP G + C P CA PC
Sbjct: 645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC 704
Query: 218 QNGGTCLQHTQVSYECLCKPEFTGLTCVKKRA 249
+G + C+C+P ++G C + A
Sbjct: 705 SHG--ICYDAPGGFRCVCEPGWSGPRCSQSLA 734
Score = 138 bits (348), Expect = 7e-33
Identities = 86/273 (31%), Positives = 109/273 (39%), Gaps = 79/273 (28%)
Query: 43 CRCQPGWQGPLCDQCVTSPGC----------LHGLCGEPGQCI---------CTDGWDGE 83
C C PGW G LCD + S C L LC GQC+ C +G G
Sbjct: 1022 CLCPPGWSGRLCD--IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGS 1079
Query: 84 LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
C+++V C + PC + GTC G Y C C PGY+G +C+ C PCQHGG+
Sbjct: 1080 HCEQEVDPCLAQPCQHGGTCRGYMGG-YMCECLPGYNGDNCEDDVDECA--SQPCQHGGS 1136
Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP-------CENDGVCTDI-------- 188
C+D R C CPPG G CEI + C P P C ++G C D+
Sbjct: 1137 CIDLVARYL---CSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTC 1193
Query: 189 ---------------------------------GGDFRCRCPAGFIDKTCSRPVTNCASS 215
GG FRC C AGF C ++ C S
Sbjct: 1194 PPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQ 1253
Query: 216 PCQNGGTCLQHT----QVSYECLCKPEFTGLTC 244
PCQ+GG C +++ C C F G C
Sbjct: 1254 PCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRC 1286
Score = 133 bits (334), Expect = 3e-31
Identities = 74/224 (33%), Positives = 96/224 (42%), Gaps = 29/224 (12%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPGQ-CICTDGWDGELCDRDVRACSSAP- 96
C C + GP C D C P G C + G C+C GW G LCD C A
Sbjct: 986 CTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAA 1045
Query: 97 ---------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD 147
C G CV D Y C C G +G C+++ PC+ PCQHGGTC
Sbjct: 1046 QIGVRLEQLCQAGGQCVDEDSSHY-CVCPEGRTGSHCEQEVDPCL--AQPCQHGGTC--- 1099
Query: 148 EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
G C C PG++G+ CE + C PC++ G C D+ + C CP G + C
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEI 1159
Query: 208 PVTNCASSP-------CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+C P C + GTC+ + C C P +TGL C
Sbjct: 1160 NEDDCGPGPPLDSGPRCLHNGTCVDLVG-GFRCTCPPGYTGLRC 1202
Score = 127 bits (320), Expect = 1e-29
Identities = 76/251 (30%), Positives = 111/251 (44%), Gaps = 54/251 (21%)
Query: 43 CRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSS 94
C+C G+ GPLC+ C SP G C + G C C G++G+ C+ +V C
Sbjct: 183 CQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPG 242
Query: 95 APCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC-------- 144
C N GTCV DG+ Y C C P ++G+ C + C + + C +GGTC
Sbjct: 243 HRCLNGGTCV---DGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHS 299
Query: 145 ---------------VDD------------EGRASHASCLCPPGFSGNFCEIVANSCTPN 177
+DD R + C CP G +G C + ++C N
Sbjct: 300 CVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHL-DDACVSN 358
Query: 178 PCENDGVC--TDIGGDFRCRCPAGFIDKTCSRPVTNCA--SSPCQNGGTCLQHTQVSYEC 233
PC D +C + G C CP GF C + V C+ ++PC++ G C+ +TQ S+ C
Sbjct: 359 PCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCV-NTQGSFLC 417
Query: 234 LCKPEFTGLTC 244
C +TG C
Sbjct: 418 QCGRGYTGPRC 428
Score = 118 bits (295), Expect = 1e-26
Identities = 84/271 (30%), Positives = 104/271 (38%), Gaps = 52/271 (19%)
Query: 22 YGAECFPACNPQNGFCEDD---------------------NVCRCQPGWQGPLC----DQ 56
Y EC P N N CEDD +C C PG G LC D
Sbjct: 1106 YMCECLPGYNGDN--CEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDD 1163
Query: 57 CV------TSPGCLH-GLCGE---PGQCICTDGWDGELCDRDVRACSSAPC--ANNGTCV 104
C + P CLH G C + +C C G+ G C+ D+ C S C A+ C+
Sbjct: 1164 CGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCL 1223
Query: 105 SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGF 162
G + C C G+SG CQ PC PCQHGG C G + C C F
Sbjct: 1224 QDPGGGFRCLCHAGFSGPRCQTVLSPC--ESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF 1281
Query: 163 SGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC--------SRPVTNCAS 214
G CE VA SC C C RC CP G +C +CA+
Sbjct: 1282 WGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAA 1341
Query: 215 SPCQNGGTCLQHTQVS-YECLCKPEFTGLTC 244
+PC +GG+C + C C +TG C
Sbjct: 1342 APCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372
Score = 38.9 bits (89), Expect = 0.008
Identities = 49/196 (25%), Positives = 67/196 (34%), Gaps = 42/196 (21%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEP--GQCICTDG 79
+G C PA P F C C GW GP C+ +P + EP + C
Sbjct: 1346 HGGSCRPA--PLAPFFR----CACAQGWTGPRCE----APAAAPEVSEEPRCPRAACQAK 1395
Query: 80 WDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQ 139
+ CDR+ C+S C +G +CS + G + C+ + N S C
Sbjct: 1396 RGDQRCDRE---CNSPGCGWDGG---------DCSLSVGDPWRQCEALQCWRLFNNSRCD 1443
Query: 140 HGGTCVDDEGRASHASCLCPPGFSGNF-CEIVANSCTPNPCENDGVCTDIGGDFRCRCPA 198
+C P NF C T NP + C D D RC
Sbjct: 1444 --------------PACSSPACLYDNFDCHAGGRERTCNPV-YEKYCADHFAD--GRCDQ 1486
Query: 199 GFIDKTCSRPVTNCAS 214
G + C +CAS
Sbjct: 1487 GCNTEECGWDGLDCAS 1502
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 157 bits (396), Expect = 2e-38
Identities = 89/249 (35%), Positives = 115/249 (46%), Gaps = 33/249 (13%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQC 74
EC A G C D C C PG+ G C D+C + P G C + +C
Sbjct: 149 ECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRC 208
Query: 75 ICTD-GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C G++G C+R+V C+SAPC +N +C+ G + C C PGYSG+ C+ + C
Sbjct: 209 DCAGTGYEGTHCEREVLECASAPCEHNASCLE-GLGSFRCLCWPGYSGELCEVDEDECA- 266
Query: 134 NGSPCQHGGTCVDDEGRA---------------SHAS---CLCPPGFSGNFCEIVANSCT 175
SPCQHGG C+ A HA+ C CPPGF G C + + C
Sbjct: 267 -SSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECA 325
Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
PC N G C D+ F+C CP G+ TC V C S PC +GGTC T Y C C
Sbjct: 326 SRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTC-SDTVAGYICRC 384
Query: 236 KPEFTGLTC 244
+ G C
Sbjct: 385 PETWGGRDC 393
Score = 149 bits (375), Expect = 5e-36
Identities = 88/252 (34%), Positives = 112/252 (44%), Gaps = 41/252 (16%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGL----CGEPGQ 73
+GA C P GF C C PG+QGP C D+C + P C HG + +
Sbjct: 78 HGALCVPQGPDPTGFR-----CYCVPGFQGPRCELDIDECASRP-CHHGATCRNLADRYE 131
Query: 74 CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
C C G+ G C+ +V C+SAPC + G+C+ G + C CAPGY G CQ C
Sbjct: 132 CHCPLGYAGVTCEMEVDECASAPCLHGGSCLD-GVGSFRCVCAPGYGGTRCQLDLDEC-- 188
Query: 134 NGSPCQHGGTCVDDEGRASHASCLCP-PGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
PC HGGTC D + C C G+ G CE C PCE++ C + G F
Sbjct: 189 QSQPCAHGGTCHD---LVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF 245
Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ--------------------VSYE 232
RC C G+ + C CASSPCQ+GG CLQ + +
Sbjct: 246 RCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFL 305
Query: 233 CLCKPEFTGLTC 244
C C P F G C
Sbjct: 306 CHCPPGFEGADC 317
Score = 123 bits (308), Expect = 3e-28
Identities = 89/286 (31%), Positives = 123/286 (43%), Gaps = 51/286 (17%)
Query: 25 ECFPACNPQNGFCED-DNVCRCQ---PGWQGPLCD----QCVTSP-----GCLHGLCGEP 71
EC G C D N RC G++G C+ +C ++P CL GL
Sbjct: 187 ECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSF- 245
Query: 72 GQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDD-GLYE------------------ 112
+C+C G+ GELC+ D C+S+PC + G C+ D LY
Sbjct: 246 -RCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGF 304
Query: 113 -CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
C C PG+ G DC + C PC +GG C D + C CP G++G CE
Sbjct: 305 LCHCPPGFEGADCGVEVDECA--SRPCLNGGHCQD---LPNGFQCHCPDGYAGPTCEEDV 359
Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL---QHTQ 228
+ C +PC + G C+D + CRCP + + CS +T C C TC+ +
Sbjct: 360 DECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGV 419
Query: 229 VSYECLCKPEFTGLTCVKK-----RALSPQQVTRLPSG--YGLAYR 267
SY C C P G C + A SP Q + +P+G GLA R
Sbjct: 420 HSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQAS-VPAGGPLGLALR 464
Score = 110 bits (274), Expect = 3e-24
Identities = 53/157 (33%), Positives = 70/157 (44%), Gaps = 19/157 (12%)
Query: 91 ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING---SPCQHGGTCVDD 147
AC+S PCA C + + G Y C GP G PC HG CV
Sbjct: 41 ACASDPCAPGTECQATESGGYTC---------------GPMEPRGCATQPCHHGALCVPQ 85
Query: 148 EGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
+ C C PGF G CE+ + C PC + C ++ + C CP G+ TC
Sbjct: 86 GPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEM 145
Query: 208 PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
V CAS+PC +GG+CL S+ C+C P + G C
Sbjct: 146 EVDECASAPCLHGGSCLDGVG-SFRCVCAPGYGGTRC 181
Score = 107 bits (268), Expect = 1e-23
Identities = 57/176 (32%), Positives = 76/176 (43%), Gaps = 10/176 (5%)
Query: 63 CLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSL--DDGLYECSCAPGYS 120
C C +C T+ + R C++ PC + CV D + C C PG+
Sbjct: 42 CASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQ 101
Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE 180
G C+ C PC HG TC A C CP G++G CE+ + C PC
Sbjct: 102 GPRCELDIDECA--SRPCHHGATC---RNLADRYECHCPLGYAGVTCEMEVDECASAPCL 156
Query: 181 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVS-YECLC 235
+ G C D G FRC C G+ C + C S PC +GGTC H V+ + C C
Sbjct: 157 HGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTC--HDLVNGFRCDC 210
Score = 104 bits (259), Expect = 2e-22
Identities = 58/156 (37%), Positives = 73/156 (46%), Gaps = 14/156 (8%)
Query: 57 CVTSPGCLH-GLCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE 112
C SP CLH G C + C C GW+G C+ V C SAPCA G C + DG +E
Sbjct: 1060 CAPSP-CLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFE 1117
Query: 113 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDD---EGRASHASCLCPPGFSGNFCEI 169
C C PG+ G C+ + C TC+D EG + A+C C G +G C++
Sbjct: 1118 CRCPPGFGGPRCRLP-----VPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQV 1172
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
C NPC N G C GG C C A F + C
Sbjct: 1173 PTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 100 bits (250), Expect = 2e-21
Identities = 56/167 (33%), Positives = 76/167 (45%), Gaps = 10/167 (5%)
Query: 87 RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD 146
R C+ +PC ++G C L D + C+C PG+ G C+ PC + +PC G
Sbjct: 1055 RGAPVCAPSPCLHDGACRDLFDA-FACACGPGWEGPRCEAHVDPC--HSAPCARGRCHTH 1111
Query: 147 DEGRASHASCLCPPGFSGNFCEIVANS--CTPN-PCENDGVCTDIGGDFRCRCPAGFIDK 203
+GR C CPPGF G C + S C+ N C + C C C G +
Sbjct: 1112 PDGRFE---CRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQ 1168
Query: 204 TCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRAL 250
C P C ++PC NGGTC VS EC+C F+G C + L
Sbjct: 1169 RCQVPTLPCEANPCLNGGTCRAAGGVS-ECICNARFSGQFCEVAKGL 1214
Score = 84.3 bits (207), Expect = 2e-16
Identities = 61/178 (34%), Positives = 74/178 (41%), Gaps = 33/178 (18%)
Query: 23 GAECFPACNPQ----NGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGEP 71
G P C P +G C D C C PGW+GP C D C ++P C G C
Sbjct: 1053 GCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAP-CARGRCHTH 1111
Query: 72 G----QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE-------CSCAPGYS 120
+C C G+ G C V S C+ N TC LD E CSC G +
Sbjct: 1112 PDGRFECRCPPGFGGPRCRLPV---PSKECSLNVTC--LDGSPCEGGSPAANCSCLEGLA 1166
Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP 178
G+ CQ PC N PC +GGTC + C+C FSG FCE+ P P
Sbjct: 1167 GQRCQVPTLPCEAN--PCLNGGTC---RAAGGVSECICNARFSGQFCEVAKGLPLPLP 1219
Score = 52.0 bits (123), Expect = 9e-07
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 2/66 (3%)
Query: 174 CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC 233
C+P+PC N G C DF C CPA F TC++ + C PC TC + + C
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLW-CPGQPCLPPATC-EEVPDGFVC 868
Query: 234 LCKPEF 239
+ + F
Sbjct: 869 VAEATF 874
Score = 46.6 bits (109), Expect = 4e-05
Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 13/93 (13%)
Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC 235
P P +N +++GG AG + + C+ PC NGGTCL T + C C
Sbjct: 781 PLPLDNSSQPSELGGRQSWNLTAGCVSEDM------CSPDPCFNGGTCLV-TWNDFHCTC 833
Query: 236 KPEFTGLTCVK------KRALSPQQVTRLPSGY 262
FTG TC + + L P +P G+
Sbjct: 834 PANFTGPTCAQQLWCPGQPCLPPATCEEVPDGF 866
Score = 36.2 bits (82), Expect = 0.051
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 6/54 (11%)
Query: 92 CSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
CS PC N GTC V+ +D + C+C ++G C ++ G PC TC
Sbjct: 811 CSPDPCFNGGTCLVTWND--FHCTCPANFTGPTCAQQ---LWCPGQPCLPPATC 859
Score = 34.3 bits (77), Expect = 0.19
Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 4/64 (6%)
Query: 137 PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
PC +GGTC+ + C CP F+G C C PC C ++ F C
Sbjct: 815 PCFNGGTCL---VTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFVCVA 870
Query: 197 PAGF 200
A F
Sbjct: 871 EATF 874
Score = 33.1 bits (74), Expect = 0.43
Identities = 13/33 (39%), Positives = 16/33 (48%)
Query: 174 CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
C P PC + G C D+ FRC C TC+
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641
Score = 29.3 bits (64), Expect = 6.2
Identities = 14/40 (35%), Positives = 20/40 (50%), Gaps = 2/40 (5%)
Query: 85 CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC 124
C+R + C PC + G+CV L + C CA + G C
Sbjct: 603 CERREQ-CRPLPCVHGGSCVDLWTH-FRCDCARPHRGPTC 640
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 154 bits (388), Expect = 2e-37
Identities = 88/265 (33%), Positives = 123/265 (46%), Gaps = 23/265 (8%)
Query: 25 ECFPACNPQNGFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PGQ--C 74
ECF +G C+ VC C G+ G C D+C P +G+C + G+ C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKDGPCV 132
C G+ G+ C+ ++ CSS+PC N G CV DG+ Y C+C G+ G C+ + C
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICV---DGVAGYRCTCVKGFVGLHCETEVNECQ 1312
Query: 133 INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF 192
N PC + C D G C CPPGF G C + C PC+N C D F
Sbjct: 1313 SN--PCLNNAVCEDQVGGFL---CKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSF 1367
Query: 193 RCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSP 252
RC C AGF C + C S+PC+N TC+ SY C C+P F+G C +++
Sbjct: 1368 RCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN-SYSCKCQPGFSGKRCETEQSTGF 1426
Query: 253 QQVTRLPS--GYGLAYRLTPGVHEL 275
+ GY + + P +H L
Sbjct: 1427 NLDFEVSGIYGYVMLDGMLPSLHAL 1451
Score = 120 bits (302), Expect = 2e-27
Identities = 71/198 (35%), Positives = 85/198 (42%), Gaps = 41/198 (20%)
Query: 83 ELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK-----KDGPCVING-- 135
E+ + C PC N+GTC L G Y C C GY+G C+ PC+ NG
Sbjct: 1188 EISSQVFHECFFNPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVC 1246
Query: 136 -----------------------------SPCQHGGTCVDDEGRASHASCLCPPGFSGNF 166
SPC + G CVD G A + C C GF G
Sbjct: 1247 KDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVD--GVAGY-RCTCVKGFVGLH 1303
Query: 167 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH 226
CE N C NPC N+ VC D G F C+CP GF+ C + V C S PC+NG TC
Sbjct: 1304 CETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDG 1363
Query: 227 TQVSYECLCKPEFTGLTC 244
S+ CLC FTG C
Sbjct: 1364 AN-SFRCLCAAGFTGSHC 1380
Score = 73.6 bits (179), Expect = 3e-13
Identities = 39/102 (38%), Positives = 49/102 (48%), Gaps = 10/102 (9%)
Query: 27 FPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCICTDGWDGELC 85
FP N G C+ N C C GW G LC++ + CL+ G C P QC C GW G C
Sbjct: 3474 FPCQN--GGICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRC 3531
Query: 86 DRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
V C S PC N G CV + C C ++G +C +K
Sbjct: 3532 HTAV--CQS-PCLNGGKCVRPN----RCHCLSSWTGHNCSRK 3566
Score = 70.5 bits (171), Expect = 2e-12
Identities = 40/128 (31%), Positives = 55/128 (42%), Gaps = 19/128 (14%)
Query: 41 NVCRCQPGWQGP-LCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCAN 99
+VC W P +C P G+C P C C +GW G LC+ + PC N
Sbjct: 3454 SVCLENGTWTSPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPI---CILPCLN 3510
Query: 100 NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP 159
G CV+ Y+C C PG++G C + SPC +GG CV C C
Sbjct: 3511 GGRCVA----PYQCDCPPGWTGSRCH-----TAVCQSPCLNGGKCVRPN------RCHCL 3555
Query: 160 PGFSGNFC 167
++G+ C
Sbjct: 3556 SSWTGHNC 3563
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/112 (33%), Positives = 49/112 (43%), Gaps = 19/112 (16%)
Query: 137 PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
PCQ+GG C +C CP G+ G CE PC N G C ++C C
Sbjct: 3475 PCQNGGICQRPN------ACSCPEGWMGRLCE---EPICILPCLNGGRCV---APYQCDC 3522
Query: 197 PAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
P G+ C V SPC NGG C++ + C C +TG C +KR
Sbjct: 3523 PPGWTGSRCHTAV---CQSPCLNGGKCVRPNR----CHCLSSWTGHNCSRKR 3567
Score = 52.4 bits (124), Expect = 7e-07
Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 10/75 (13%)
Query: 178 PCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKP 237
PC+N G+C C CP G++ + C P+ PC NGG C+ Y+C C P
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI---CILPCLNGGRCV----APYQCDCPP 3524
Query: 238 EFTGLTCVKKRALSP 252
+TG C SP
Sbjct: 3525 GWTGSRCHTAVCQSP 3539
Score = 48.1 bits (113), Expect = 1e-05
Identities = 22/57 (38%), Positives = 24/57 (42%), Gaps = 1/57 (1%)
Query: 35 GFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG-LCGEPGQCICTDGWDGELCDRDVR 90
G C C C PGW G C V CL+G C P +C C W G C R R
Sbjct: 3512 GRCVAPYQCDCPPGWTGSRCHTAVCQSPCLNGGKCVRPNRCHCLSSWTGHNCSRKRR 3568
Score = 38.5 bits (88), Expect = 0.010
Identities = 53/222 (23%), Positives = 71/222 (31%), Gaps = 44/222 (19%)
Query: 84 LCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGT 143
LCD C GT G +EC C GY GK Q
Sbjct: 280 LCDEGKDCCDRMGSCKCGT----HTGHFECICEKGYYGKGLQY----------------- 318
Query: 144 CVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDK 203
E A + P G G +SC P P EN C C G+
Sbjct: 319 ----ECTACPSGTYKPEGSPGGI-----SSCIPCPDENHTSPPGSTSPEDCVCREGYRAS 369
Query: 204 TCSRPVTNC-ASSPCQNG----GTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRL 258
+ + +C A P +NG TC H + C P F + + L
Sbjct: 370 GQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFD--------LVGSSIILCL 421
Query: 259 PSGYGLAYRLTPGVHELP-VQQPEHRILKVSMKELNKKTPLL 299
P+G V P ++QP+H + S +E+ KT L
Sbjct: 422 PNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCL 463
Score = 35.0 bits (79), Expect = 0.11
Identities = 44/173 (25%), Positives = 65/173 (37%), Gaps = 41/173 (23%)
Query: 32 PQNGFCEDDNVCRCQPGWQGPLCDQ----CVTSPGCLHGLCGEPGQCICTDGWDGELCDR 87
P F +DD V C LCD+ C C G +CIC G+ G+
Sbjct: 265 PSGSFIQDDMV-HCSY-----LCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQY 318
Query: 88 DVRACSSAPCANNG------TCVSLDDGLY----------ECSCAPGY--SGKDCQKKDG 129
+ AC S G +C+ D + +C C GY SG+ C+
Sbjct: 319 ECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHC 378
Query: 130 PCVINGSPCQHGGTCVDDEGRASHASC--LCPPGFSGNFCEIVANS---CTPN 177
P + P ++G + +A+C C PGF ++V +S C PN
Sbjct: 379 PAL---KPPENGYFIQNTCNNHFNAACGVRCHPGF-----DLVGSSIILCLPN 423
Score = 35.0 bits (79), Expect = 0.11
Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 8/68 (11%)
Query: 76 CTDG--WDGELCD-RDVRACS-SAPCANNGTCVSLDDGLYECSCAPGYS--GKDCQKKDG 129
CTD W+G DV C+ + C+ + +C+++D G Y CSC P Y+ GK+C +
Sbjct: 1730 CTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVD-GSYICSCVPPYTGDGKNCAEPI- 1787
Query: 130 PCVINGSP 137
C G+P
Sbjct: 1788 KCKAPGNP 1795
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 150 bits (378), Expect = 2e-36
Identities = 79/267 (29%), Positives = 115/267 (43%), Gaps = 48/267 (17%)
Query: 25 ECFPACNPQNGFCEDDNV---CRCQPGWQGPLCDQ----CVTSPGCLHGLCGE---PGQC 74
+C N C+D ++ C C W+G C+Q C +P + C + +C
Sbjct: 736 DCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRC 795
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTC-VSLDDGLYECSCAPGYSGKDCQKKDGPCVI 133
CT GW G+ C ++ C S PC N G C S G + C C P Y+G+ C ++ C +
Sbjct: 796 ECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDL 855
Query: 134 NGSPCQHGGTCV------------------------------------DDEGRASHASCL 157
+PC++ TC+ D E ++ C+
Sbjct: 856 LHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCI 915
Query: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
C PGFSG+ CEI N C+ PC+N+G C D+ F C C + C V C SPC
Sbjct: 916 CRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPC 975
Query: 218 QNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C+ T Y CLC P +TG+ C
Sbjct: 976 LDEENCVYRTD-GYNCLCAPGYTGINC 1001
Score = 147 bits (372), Expect = 1e-35
Identities = 79/222 (35%), Positives = 109/222 (49%), Gaps = 18/222 (8%)
Query: 35 GFCED---DNVCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ---CICTDGWDGEL 84
G CED + C C+PG+ G LC+ +C + P +G C + C C + G
Sbjct: 903 GDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPF 962
Query: 85 CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
C+ DV C +PC + CV DG Y C CAPGY+G +C+ C+ PC H G C
Sbjct: 963 CELDVNKCKISPCLDEENCVYRTDG-YNCLCAPGYTGINCEINLDECL--SEPCLHDGVC 1019
Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
+D +H +C C GF G CE AN C NPC + G CT++ ++ C C A
Sbjct: 1020 IDG---INHYTCDCKSGFFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQ 1075
Query: 205 CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
C + +C S PC N G C Q + + C+C +TG C K
Sbjct: 1076 CKIKINDCTSIPCMNEGFC-QKSAHGFTCICPRGYTGAYCEK 1116
Score = 140 bits (354), Expect = 1e-33
Identities = 68/186 (36%), Positives = 94/186 (50%), Gaps = 25/186 (13%)
Query: 76 CTDGWDGELCDRDVRACSSAPCANNGTCVS--------------LDDGLYECSCAPGYSG 121
C G+ G C+ D+ C+S PC N TC+ + DG + C C PGY G
Sbjct: 669 CVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDG-FSCLCNPGYVG 727
Query: 122 KDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIVANSCTPNPC 179
C++ C++N C+H TC D H S C+C + GNFCE +N C NPC
Sbjct: 728 IRCEQDIDDCILNA--CEHNSTCKD-----LHLSYQCVCLSDWEGNFCEQESNECKMNPC 780
Query: 180 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT-QVSYECLCKPE 238
+N+ CTD+ +RC C +G+ + CS + C S PC NGG C + T + CLC P
Sbjct: 781 KNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPL 840
Query: 239 FTGLTC 244
+TG C
Sbjct: 841 YTGQFC 846
Score = 140 bits (354), Expect = 1e-33
Identities = 86/291 (29%), Positives = 118/291 (40%), Gaps = 70/291 (24%)
Query: 23 GAECFPACNPQNGFCE--------DDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG-- 72
GA C P N FC+ D C C PG+ G C+Q + C+ C
Sbjct: 693 GATCID--QPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDD--CILNACEHNSTC 748
Query: 73 -------QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ 125
QC+C W+G C+++ C PC NN TC L Y C C G++G++C
Sbjct: 749 KDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKS-YRCECTSGWTGQNCS 807
Query: 126 KKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC--TPNPCEND- 182
++ C + PC +GG C + CLCPP ++G FC N C NPC N+
Sbjct: 808 EEINEC--DSDPCMNGGLC-HESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNS 864
Query: 183 --------------------------------------GVCTDIGGDFRCRCPAGFIDKT 204
G C D+ +FRC C GF
Sbjct: 865 TCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSL 924
Query: 205 CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC---VKKRALSP 252
C + C+S PC+N GTC+ T + C C+PE+ G C V K +SP
Sbjct: 925 CEIEINECSSEPCKNNGTCVDLTN-RFFCNCEPEYHGPFCELDVNKCKISP 974
Score = 135 bits (340), Expect = 6e-32
Identities = 74/211 (35%), Positives = 101/211 (47%), Gaps = 19/211 (9%)
Query: 43 CRCQPGWQGPLCDQCVTSPGCLHGLCGEPG---------QCICTDGWDGELCDRDVRACS 93
C C+ ++G C+ + CL C + G +CIC G+ G LC+ ++ CS
Sbjct: 876 CICREEFEGKNCE--IDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECS 933
Query: 94 SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH 153
S PC NNGTCV L + + C+C P Y G C+ C I SPC CV R
Sbjct: 934 SEPCKNNGTCVDLTNRFF-CNCEPEYHGPFCELDVNKCKI--SPCLDEENCVY---RTDG 987
Query: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
+CLC PG++G CEI + C PC +DGVC D + C C +GF C +C
Sbjct: 988 YNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCL 1047
Query: 214 SSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
S+PC + G C + Y C C + T C
Sbjct: 1048 SNPCLH-GRCTELIN-EYPCSCDADGTSTQC 1076
Score = 121 bits (303), Expect = 1e-27
Identities = 77/233 (33%), Positives = 104/233 (44%), Gaps = 22/233 (9%)
Query: 25 ECFPACNPQNGFCEDD---NVCRCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQC 74
EC +G C D C C+ G+ G C+ C+++P CLHG C E C
Sbjct: 1007 ECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNP-CLHGRCTELINEYPC 1065
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV-- 132
C C + C+S PC N G C G + C C GY+G C+K C
Sbjct: 1066 SCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG-FTCICPRGYTGAYCEKSIDNCAEP 1124
Query: 133 -INGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
+N C +GG CVD G C C PGFSG FCEI N C+ +PC + C D
Sbjct: 1125 ELNSVICLNGGICVDGPGHTF--DCRCLPGFSGQFCEININECSSSPCLHGADCEDHING 1182
Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C+C G+ C + C + C + C+++ S CLC P F +TC
Sbjct: 1183 YVCKCQPGWSGHHCENEL-ECIPNSCVH-ELCMENEPGS-TCLCTPGF--MTC 1230
Score = 105 bits (261), Expect = 9e-23
Identities = 62/201 (30%), Positives = 92/201 (45%), Gaps = 17/201 (8%)
Query: 54 CDQCVTSPGCL-HGLC-----GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCV--- 104
C + ++S C HG C + C C + G+ C +++ ACS PC NNG+C+
Sbjct: 174 CQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDACSFKPCKNNGSCINKR 232
Query: 105 -SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS 163
+ D+ YEC C P ++GK+C + G C C HG ++ C C FS
Sbjct: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC--QPHVCFHGNC---SNITSNSFICECDEQFS 287
Query: 164 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC 223
G FCE+ A C G+C + + CP G + V+ + PCQNG C
Sbjct: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDC 347
Query: 224 LQHTQVSYECLCKPEFTGLTC 244
++ + C+C P FT L C
Sbjct: 348 IKISN-DVMCICSPIFTDLLC 367
Score = 85.1 bits (209), Expect = 1e-16
Identities = 60/251 (23%), Positives = 93/251 (37%), Gaps = 54/251 (21%)
Query: 43 CRCQPGWQGPLC---DQCVTSPGCLHGLC--------GEPGQCICTDGWDGELCDRDVRA 91
C CQP + G C D C P +G C + +C+C + G+ C +
Sbjct: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVI------------------ 133
C C + G C ++ + C C +SG C+ PCV
Sbjct: 260 CQPHVCFH-GNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTY 318
Query: 134 ---------NGS---------PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT 175
NG PCQ+G C+ ++ C+C P F+ C+ + SC
Sbjct: 319 ECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI---SNDVMCICSPIFTDLLCKSIQTSCE 375
Query: 176 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC--ASSPCQNGGTCLQHTQVSYEC 233
P N+ C D+ C C +GF +K C + + +C S C N C + ++
Sbjct: 376 SFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCF-NIIGRFKY 434
Query: 234 LCKPEFTGLTC 244
+C P T C
Sbjct: 435 VCIPGCTKNPC 445
Score = 77.0 bits (188), Expect = 3e-14
Identities = 50/201 (24%), Positives = 74/201 (36%), Gaps = 18/201 (8%)
Query: 57 CVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCA 116
C CL + + +C W G + + C + C + CSC+
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKD-EINRPRCSCS 593
Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTP 176
Y G+ C C+ N S HG C+ + + +C + N CEI C
Sbjct: 594 LSYIGRLCVVNVDYCLGNHSISVHG-LCL---ALSHNCNCSGLQRYERNICEIDTEDCKS 649
Query: 177 NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH---------- 226
C+N T + G F +C GF C + CAS PC+NG TC+
Sbjct: 650 ASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVP 709
Query: 227 ---TQVSYECLCKPEFTGLTC 244
+ CLC P + G+ C
Sbjct: 710 PFKVVDGFSCLCNPGYVGIRC 730
Score = 60.8 bits (146), Expect = 2e-09
Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 7/85 (8%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRA 151
C+ C NNGTC+S ++ L+ C C YSGK CQ +PC +G TCV G
Sbjct: 2339 CAHHLCRNNGTCISDNENLF-CECPRLYSGKLCQFAS----CENNPCGNGATCVPKSG-- 2391
Query: 152 SHASCLCPPGFSGNFCEIVANSCTP 176
+ CLCP G SG C N P
Sbjct: 2392 TDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 56.2 bits (134), Expect = 5e-08
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 1/79 (1%)
Query: 173 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE 232
+C N C N G CT G F CRC + TC++ V +C ++ C + C+ SY
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYS 2936
Query: 233 CLCKPEFTGLTCVKKRALS 251
CLC + G C K + S
Sbjct: 2937 CLCTLGWVGRYCENKTSFS 2955
Score = 53.5 bits (127), Expect = 3e-07
Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP---CQHGGTCVDDE 148
CS C N GTC+ +Y C+C G+ G C + C P C G TC+
Sbjct: 2614 CSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS-- 2670
Query: 149 GRASHA-SCLCPPGFSGNFCEIVANSCTPNPCEND 182
H +C CP G +G +CE + P+ N+
Sbjct: 2671 --LPHGYTCFCPLGTTGIYCEQALSISDPSFRSNE 2703
Score = 50.1 bits (118), Expect = 3e-06
Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 174 CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC 233
C + C N+G C + C CP + K C +C ++PC NG TC+ + C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396
Query: 234 LCKPEFTGLTC 244
LC +G C
Sbjct: 2397 LCPYGRSGPLC 2407
Score = 49.7 bits (117), Expect = 4e-06
Identities = 25/70 (35%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
Query: 138 CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG-DFRCRC 196
C++ GTC+ D + C CP +SG C+ SC NPC N C G D C C
Sbjct: 2344 CRNNGTCISDN---ENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLC 2398
Query: 197 PAGFIDKTCS 206
P G C+
Sbjct: 2399 PYGRSGPLCT 2408
Score = 49.7 bits (117), Expect = 4e-06
Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 6/83 (7%)
Query: 86 DRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
D D AC C N G C +++ + C C P ++G C + C+ N C H C+
Sbjct: 2873 DCDGTACGYNTCRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSVS-CLNN--LCLHQSLCI 2928
Query: 146 DDEGRASHASCLCPPGFSGNFCE 168
D+ + SCLC G+ G +CE
Sbjct: 2929 PDQSFSY--SCLCTLGWVGRYCE 2949
Score = 49.3 bits (116), Expect = 6e-06
Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 16/85 (18%)
Query: 56 QCVTSPGCLHGLCGEPGQCI---------CTDGWDGELCDRDVRACSSA-----PCANNG 101
QC SP C CG G CI CT GW G C V C C+
Sbjct: 2608 QCHASP-CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666
Query: 102 TCVSLDDGLYECSCAPGYSGKDCQK 126
TC+SL G Y C C G +G C++
Sbjct: 2667 TCISLPHG-YTCFCPLGTTGIYCEQ 2690
Score = 46.6 bits (109), Expect = 4e-05
Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 6/86 (6%)
Query: 171 ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNC-----ASSPCQNGGTCLQ 225
A+ C+ C N G C + G C C G+ C+ V+ C C G TC+
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670
Query: 226 HTQVSYECLCKPEFTGLTCVKKRALS 251
Y C C TG+ C + ++S
Sbjct: 2671 LPH-GYTCFCPLGTTGIYCEQALSIS 2695
Score = 45.4 bits (106), Expect = 8e-05
Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 10/86 (11%)
Query: 130 PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC-----TPNPCENDGV 184
PC + C +GGTC++ + C C G+ G+FC ++C P+ C
Sbjct: 2613 PCSL--MKCGNGGTCIES---GTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 185 CTDIGGDFRCRCPAGFIDKTCSRPVT 210
C + + C CP G C + ++
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCEQALS 2693
Score = 43.5 bits (101), Expect = 3e-04
Identities = 25/73 (34%), Positives = 29/73 (39%), Gaps = 11/73 (15%)
Query: 61 PGCLHGLCGEPGQCI---------CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLY 111
P C H LC G CI C + G+LC +C + PC N TCV
Sbjct: 2337 PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDI 2394
Query: 112 ECSCAPGYSGKDC 124
C C G SG C
Sbjct: 2395 VCLCPYGRSGPLC 2407
Score = 42.4 bits (98), Expect = 7e-04
Identities = 21/51 (41%), Positives = 25/51 (49%), Gaps = 7/51 (13%)
Query: 43 CRCQPGWQGPLCDQCVTSPG--CLHGLCGEPGQ-----CICTDGWDGELCD 86
CRC P W G C+Q V+ CLH P Q C+CT GW G C+
Sbjct: 2899 CRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 39.7 bits (91), Expect = 0.005
Identities = 17/59 (28%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 69 GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
G C C W G C++ V +C + C + C+ Y C C G+ G+ C+ K
Sbjct: 2894 GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENK 2951
Score = 35.4 bits (80), Expect = 0.087
Identities = 18/43 (41%), Positives = 20/43 (46%), Gaps = 4/43 (9%)
Query: 212 CASSPCQNGGTC----LQHTQVSYECLCKPEFTGLTCVKKRAL 250
C C NGGTC L VS++C C FTG C K L
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGL 2145
Score = 33.5 bits (75), Expect = 0.33
Identities = 13/35 (37%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
T C + C+NGG C + ++ C C P++ G TC
Sbjct: 2877 TACGYNTCRNGGECTVN-GTTFSCRCLPDWAGNTC 2910
Score = 31.6 bits (70), Expect = 1.3
Identities = 14/42 (33%), Positives = 22/42 (52%), Gaps = 4/42 (9%)
Query: 92 CSSAPCANNGTC--VSLDDGL--YECSCAPGYSGKDCQKKDG 129
C C N GTC + L G+ ++C C ++G+ C+K G
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG 2144
Score = 29.6 bits (65), Expect = 4.8
Identities = 17/42 (40%), Positives = 19/42 (45%), Gaps = 4/42 (9%)
Query: 130 PCVINGSPCQHGGTCVD---DEGRASHASCLCPPGFSGNFCE 168
P V C +GGTC G S C CP F+G FCE
Sbjct: 2100 PSVCQQDVCHNGGTCHAIFLSSGIVSF-QCDCPLHFTGRFCE 2140
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 150 bits (378), Expect = 2e-36
Identities = 91/244 (37%), Positives = 115/244 (47%), Gaps = 39/244 (15%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHG-LC--GEPG-QCICT-DGWDGELCDRDVRACS 93
C C PG+ G C D+C + P CLHG LC GE C CT G+ G C+ + C
Sbjct: 248 CDCAPGFLGDHCELNTDECASQP-CLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCW 306
Query: 94 SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD-----DE 148
S PC NN TC D Y C C PGY+G C+ C N +PCQ G CV+
Sbjct: 307 SKPCHNNATCEDSVDN-YTCHCWPGYTGAQCEIDLNEC--NSNPCQSNGECVELSSEKQY 363
Query: 149 GR------------ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
GR AS C+C PGF+G CE N C+ NPC+N G C ++ G++ C C
Sbjct: 364 GRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423
Query: 197 PAGFIDKT------CSRPVTNCASSPCQNGGTCLQH---TQVSYECLCKPEFTGLTCVKK 247
P + +T CS + C C N GTC+ H Q + CLC +TG C
Sbjct: 424 PFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIA 483
Query: 248 RALS 251
LS
Sbjct: 484 TTLS 487
Score = 149 bits (375), Expect = 5e-36
Identities = 76/211 (36%), Positives = 105/211 (49%), Gaps = 15/211 (7%)
Query: 42 VCRCQPGWQGPLCDQCVTSPG---CLHG-LCGEPG---QCICTDGWDGELCDRDVRACSS 94
+C+C PG+ G +C+ + S G C HG +C + CIC G+ G C+ D C+S
Sbjct: 95 LCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECAS 154
Query: 95 APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA 154
+PC N C DG Y C C PGY G+ C + C PC++ TC+++ GR +
Sbjct: 155 SPCQNGAVCQDGIDG-YSCFCVPGYQGRHCDLEVDECA--SDPCKNEATCLNEIGRYT-- 209
Query: 155 SCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCAS 214
C+CP +SG CE+ + C PC N C D G + C C GF+ C CAS
Sbjct: 210 -CICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECAS 268
Query: 215 SPCQNGGTCLQHTQVSYECLCKPE-FTGLTC 244
PC +GG C+ + Y C C FTG C
Sbjct: 269 QPCLHGGLCVD-GENRYSCNCTGSGFTGTHC 298
Score = 135 bits (340), Expect = 6e-32
Identities = 74/215 (34%), Positives = 102/215 (47%), Gaps = 19/215 (8%)
Query: 33 QNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDG--ELCDRDVR 90
+N FC +N RC L + C + C + C C+D + + CD
Sbjct: 23 KNSFCNKNNT-RC-------LSNSCQNNSTCKD--FSKDNDCSCSDTANNLDKDCDNMKD 72
Query: 91 ACSSAPCANNGTCVSLD-DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEG 149
C S PC + TCV+ + + C C PGYSG C+ G C N CQHGG C D
Sbjct: 73 PCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNS--CQHGGICHQDP- 129
Query: 150 RASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV 209
+ C+CP G++G FCEI + C +PC+N VC D + C C G+ + C V
Sbjct: 130 --IYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187
Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
CAS PC+N TCL Y C+C ++G+ C
Sbjct: 188 DECASDPCKNEATCLNEIG-RYTCICPHNYSGVNC 221
Score = 127 bits (318), Expect = 2e-29
Identities = 72/234 (30%), Positives = 100/234 (42%), Gaps = 23/234 (9%)
Query: 26 CFPACNPQNGFCED---DNVCRCQPGWQG------PLCDQCVTSPGCLHGLC-GEPGQ-- 73
C N C+D DN C C + D C ++P C PG+
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93
Query: 74 --CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYE-CSCAPGYSGKDCQKKDGP 130
C C G+ G +C+ + +C C + G C D +Y C C GY+G+ C+
Sbjct: 94 FLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQ--DPIYPVCICPAGYAGRFCEIDHDE 151
Query: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGG 190
C SPCQ+G C D SC C PG+ G C++ + C +PC+N+ C + G
Sbjct: 152 CA--SSPCQNGAVCQDG---IDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206
Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C CP + C + C S PC NG TC Q +Y C C P F G C
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCLNGATC-QDALGAYFCDCAPGFLGDHC 259
Score = 127 bits (318), Expect = 2e-29
Identities = 64/186 (34%), Positives = 93/186 (50%), Gaps = 20/186 (10%)
Query: 35 GFCED---DNVCRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGEL 84
G CED C C GW G C D+C ++P C+HG C + C C G+ G
Sbjct: 1152 GNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCTCEPGYTGVN 1210
Query: 85 CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP-----CQ 139
C+ D+ C S CAN TC+S +G Y C C ++GK C++ P + G+ C
Sbjct: 1211 CEVDIDNCQSHQCANGATCISHTNG-YSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCY 1269
Query: 140 HGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAG 199
+GG C + + + C+C PGF+G +CE + C +PC N G+C D+ F+C C
Sbjct: 1270 NGGNCTEFQ---TELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVA 1326
Query: 200 FIDKTC 205
F + C
Sbjct: 1327 FAGERC 1332
Score = 123 bits (309), Expect = 2e-28
Identities = 70/215 (32%), Positives = 94/215 (43%), Gaps = 26/215 (12%)
Query: 37 CEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAP 96
C NVC P G C+ +S C C GW G+ C+ ++ C S P
Sbjct: 1137 CLQLNVCNSNPCLHGGNCEDIYSSY-----------HCSCPLGWSGKHCELNIDECFSNP 1185
Query: 97 CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASC 156
C + G C S Y C+C PGY+G +C+ C C +G TC+ + SC
Sbjct: 1186 CIH-GNC-SDRVAAYHCTCEPGYTGVNCEVDIDNC--QSHQCANGATCIS---HTNGYSC 1238
Query: 157 LCPPGFSGNFCE-------IVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV 209
LC F+G FC + N T C N G CT+ + +C C GF + C + +
Sbjct: 1239 LCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI 1298
Query: 210 TNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
CAS PC NGG C Q ++CLC F G C
Sbjct: 1299 DECASDPCVNGGLC-QDLLNKFQCLCDVAFAGERC 1332
Score = 104 bits (260), Expect = 1e-22
Identities = 57/165 (34%), Positives = 77/165 (46%), Gaps = 15/165 (9%)
Query: 89 VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
+ C+S PC + G C + Y CSC G+SGK C+ C N PC HG C D
Sbjct: 1140 LNVCNSNPCLHGGNCEDIYSS-YHCSCPLGWSGKHCELNIDECFSN--PCIHGN-CSD-- 1193
Query: 149 GRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR- 207
R + C C PG++G CE+ ++C + C N C + C C F K C +
Sbjct: 1194 -RVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQS 1252
Query: 208 --PVTNCASSP----CQNGGTCLQHTQVSYECLCKPEFTGLTCVK 246
P T C + C NGG C + Q +C+C+P FTG C K
Sbjct: 1253 RLPSTVCGNEKTNLTCYNGGNCTEF-QTELKCMCRPGFTGEWCEK 1296
Score = 98.6 bits (244), Expect = 8e-21
Identities = 48/117 (41%), Positives = 59/117 (50%), Gaps = 5/117 (4%)
Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
V N +PC HGG C D S C CP G+SG CE+ + C NPC + G C+D
Sbjct: 1142 VCNSNPCLHGGNCEDIY---SSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVAA 1197
Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
+ C C G+ C + NC S C NG TC+ HT Y CLC FTG C + R
Sbjct: 1198 YHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTN-GYSCLCFGNFTGKFCRQSR 1253
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/173 (34%), Positives = 74/173 (42%), Gaps = 40/173 (23%)
Query: 34 NGFCED--DN-VCRCQPGWQGPLCD----QCVTSPGCLHGLCGEPGQ------------- 73
N CED DN C C PG+ G C+ +C ++P +G C E
Sbjct: 313 NATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSS 372
Query: 74 ----------CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC------AP 117
CIC G+ G C+ DV CSS PC N GTC +L G Y C C
Sbjct: 373 FSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENL-PGNYTCHCPFDNLSRT 431
Query: 118 GYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHA-SCLCPPGFSGNFCEI 169
Y G+DC C C + GTC+ H SCLCP G++G+ CEI
Sbjct: 432 FYGGRDCSDILLGC--THQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEI 482
Score = 59.3 bits (142), Expect = 6e-09
Identities = 30/70 (42%), Positives = 33/70 (47%), Gaps = 2/70 (2%)
Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
NSC NPC N GVC DF C CPA K C V C SPC +G C Q +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQC-QPVLQGF 946
Query: 232 ECLCKPEFTG 241
EC+ F G
Sbjct: 947 ECIANAVFNG 956
Score = 41.6 bits (96), Expect = 0.001
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 4/54 (7%)
Query: 91 ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
+C S PC N G C S D + CSC SGK C++ SPC HG C
Sbjct: 890 SCKSNPCHNGGVCHSRWDD-FSCSCPALTSGKACEEVQW---CGFSPCPHGAQC 939
Score = 39.7 bits (91), Expect = 0.005
Identities = 26/73 (35%), Positives = 30/73 (41%), Gaps = 6/73 (8%)
Query: 128 DGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
D C N PC +GG C R SC CP SG CE V C +PC + C
Sbjct: 888 DNSCKSN--PCHNGGVC---HSRWDDFSCSCPALTSGKACEEV-QWCGFSPCPHGAQCQP 941
Query: 188 IGGDFRCRCPAGF 200
+ F C A F
Sbjct: 942 VLQGFECIANAVF 954
Score = 38.9 bits (89), Expect = 0.008
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 7/54 (12%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDV 89
C C+PG+ G C D+C + P GLC + QC+C + GE C+ D+
Sbjct: 1283 CMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDL 1336
Score = 33.9 bits (76), Expect = 0.25
Identities = 13/36 (36%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
C S PCQ+ G C+ + +SY+C C + G C+++
Sbjct: 676 CESQPCQSRGRCI-NLWLSYQCDCHRPYEGPNCLRE 710
Score = 33.1 bits (74), Expect = 0.43
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK 127
C S PC + G C++L Y+C C Y G +C ++
Sbjct: 676 CESQPCQSRGRCINLWLS-YQCDCHRPYEGPNCLRE 710
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 147 bits (371), Expect = 2e-35
Identities = 79/218 (36%), Positives = 101/218 (46%), Gaps = 26/218 (11%)
Query: 43 CRCQPGWQGPLC---DQCVTSPGCLHG--------LCGEPGQCICTDGWDGELCDRDVRA 91
C C PG G LC D C++ P HG L G C+C G+ G C +D+
Sbjct: 379 CLCPPGRTGLLCHLEDMCLSQP--CHGDAQCSTNPLTGST-LCLCQPGYSGPTCHQDLDE 435
Query: 92 CSSA-----PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD 146
C A PC + G+C++ G + C C PGY+G C+ C+ PC G TC+D
Sbjct: 436 CLMAQQGPSPCEHGGSCLNTP-GSFNCLCPPGYTGSRCEADHNECL--SQPCHPGSTCLD 492
Query: 147 DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
+ CLCPPG G CE+ N C PC N C D+ F+C C GF C
Sbjct: 493 ---LLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE 549
Query: 207 RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C SSPC NGG C Q ++ C C P F G C
Sbjct: 550 EDIDECRSSPCANGGQC-QDQPGAFHCKCLPGFEGPRC 586
Score = 143 bits (361), Expect = 2e-34
Identities = 82/233 (35%), Positives = 107/233 (45%), Gaps = 25/233 (10%)
Query: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTS----PGCLHG--LCGEPG- 72
A+C + NP G +C CQPG+ GP C D+C+ + C HG PG
Sbjct: 405 AQC--STNPLTG----STLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGS 458
Query: 73 -QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC 131
C+C G+ G C+ D C S PC TC+ L + C C PG G+ C+ + C
Sbjct: 459 FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDL-LATFHCLCPPGLEGQLCEVETNEC 517
Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
+PC + C D + C+C PGFSG CE + C +PC N G C D G
Sbjct: 518 A--SAPCLNHADCHD---LLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGA 572
Query: 192 FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
F C+C GF C V C S PC G +CL ++ CLC FTG C
Sbjct: 573 FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLD-LPGAFFCLCPSGFTGQLC 624
Score = 140 bits (353), Expect = 2e-33
Identities = 76/214 (35%), Positives = 106/214 (49%), Gaps = 16/214 (7%)
Query: 43 CRCQPGWQGPLC---DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRAC--SS 94
C C PGW G C D C +P G+C QC C G++G C+RDV C
Sbjct: 143 CSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDP 202
Query: 95 APCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC-VDDEGRASH 153
PC +C + G ++C C G G C+ + GPC G C +GGTC + E ++
Sbjct: 203 GPCPKGTSCHNTL-GSFQCLCPVGQEGPRCELRAGPCPPRG--CSNGGTCQLMPEKDSTF 259
Query: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
CLCPPGF G CE+ ++C + C+N G C D + C CP + CS V C
Sbjct: 260 HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECE 319
Query: 214 SS---PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ C+NGGTC Q++ S+ C+C + G +C
Sbjct: 320 TQGPPHCRNGGTC-QNSAGSFHCVCVSGWGGTSC 352
Score = 140 bits (352), Expect = 2e-33
Identities = 77/221 (34%), Positives = 95/221 (42%), Gaps = 26/221 (11%)
Query: 43 CRCQPGWQGPLC----DQCVTSPGCLHGLCGEPG---QCICTDGWDGELCDRDVRACSSA 95
C C G+ G C D C P + C + G C+C GW G LC+ + +C A
Sbjct: 830 CLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKA 889
Query: 96 P----------CANNGTCVSLDDG-LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
C N G CV D G Y C C PG+ G CQ PC PCQ+G TC
Sbjct: 890 ALSQGIDVSSLCHNGGLCV--DSGPSYFCHCPPGFQGSLCQDHVNPC--ESRPCQNGATC 945
Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
+ + S C C PG+ G C ++C PC N G CT G F C CP GF+
Sbjct: 946 M---AQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLR 1002
Query: 205 CSRPVTNCASSPCQNGGTCLQHTQV-SYECLCKPEFTGLTC 244
C V C PC GT H+ ++ C C P TG C
Sbjct: 1003 CEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWC 1043
Score = 137 bits (345), Expect = 2e-32
Identities = 79/240 (32%), Positives = 106/240 (44%), Gaps = 31/240 (12%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVT---SPGCLHGLCGEPGQ----C 74
+G C+P + N C C G+ GP C + +T S CL+G P C
Sbjct: 702 HGGTCYPQPSGYN--------CTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYC 753
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
C G C C SAPC N GTCV+ G + C CA G+ G C+ K P +
Sbjct: 754 TCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRP-GTFSCLCAMGFQGPRCEGKLRPSCAD 812
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
SPC++ TC D CLCP G++G C+ + + C PC + C G F C
Sbjct: 813 -SPCRNRATCQDS---PQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHC 868
Query: 195 RCPAGFIDKTCSRPVTNC----------ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C G+ C+ P+++C SS C NGG C+ + SY C C P F G C
Sbjct: 869 LCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVD-SGPSYFCHCPPGFQGSLC 927
Score = 137 bits (345), Expect = 2e-32
Identities = 81/237 (34%), Positives = 104/237 (43%), Gaps = 29/237 (12%)
Query: 29 ACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSPGCLHGLC-GEPG--QCICTDGWD 81
+CNP G C C P GP C D CV++P G C PG C+C G+
Sbjct: 743 SCNPSPG----GYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQ 798
Query: 82 GELCDRDVR-ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
G C+ +R +C+ +PC N TC G C C GY+G CQ C PC
Sbjct: 799 GPRCEGKLRPSCADSPCRNRATCQDSPQGP-RCLCPTGYTGGSCQTLMDLCA--QKPCPR 855
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC----------TPNPCENDGVCTDIGG 190
C+ G + H CLC G++G C + +SC + C N G+C D G
Sbjct: 856 NSHCLQT-GPSFH--CLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP 912
Query: 191 DFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
+ C CP GF C V C S PCQNG TC+ Y C C P + G C K+
Sbjct: 913 SYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPS-GYLCQCAPGYDGQNCSKE 968
Score = 135 bits (341), Expect = 5e-32
Identities = 75/223 (33%), Positives = 105/223 (47%), Gaps = 29/223 (13%)
Query: 41 NVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRA 91
++C C PG+ GP C+ QC C GL + C+C + W G C DV
Sbjct: 260 HLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGL--DTYTCLCPETWTGWDCSEDVDE 317
Query: 92 CSSAP---CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDE 148
C + C N GTC + G + C C G+ G C++ C+ + C G TC+D
Sbjct: 318 CETQGPPHCRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCI--AATCAPGSTCID-- 372
Query: 149 GRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCT--DIGGDFRCRCPAGFIDKTCS 206
R SCLCPPG +G C + + C PC D C+ + G C C G+ TC
Sbjct: 373 -RVGSFSCLCPPGRTGLLCHL-EDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCH 430
Query: 207 RPVTNC-----ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ + C SPC++GG+CL +T S+ CLC P +TG C
Sbjct: 431 QDLDECLMAQQGPSPCEHGGSCL-NTPGSFNCLCPPGYTGSRC 472
Score = 135 bits (339), Expect = 8e-32
Identities = 78/268 (29%), Positives = 105/268 (39%), Gaps = 68/268 (25%)
Query: 43 CRCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSA 95
C C PG +G LC+ +C ++P H C + QCIC G+ G C+ D+ C S+
Sbjct: 499 CLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSS 558
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKK-----DGPCVINGSP------------- 137
PCAN G C G + C C PG+ G CQ + PC + S
Sbjct: 559 PCANGGQCQD-QPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPS 617
Query: 138 ----------------CQHGGTCVDDEGRAS-------------------------HASC 156
CQ C D + +A+ +SC
Sbjct: 618 GFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSC 677
Query: 157 LCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
+C G++G CE C PC + G C + C CP G+ TCS +T C S P
Sbjct: 678 VCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGP 737
Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C NGG+C + Y C C P TG C
Sbjct: 738 CLNGGSC-NPSPGGYYCTCPPSHTGPQC 764
Score = 131 bits (329), Expect = 1e-30
Identities = 72/218 (33%), Positives = 100/218 (45%), Gaps = 23/218 (10%)
Query: 43 CRCQPGWQGPLCD----QCVTSPG------CLHGLCGEPGQCICTDGWDGELCDRDVRAC 92
C C PG++G C+ +C PG H G QC+C G +G C+ C
Sbjct: 180 CHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGS-FQCLCPVGQEGPRCELRAGPC 238
Query: 93 SSAPCANNGTCVSL---DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEG 149
C+N GTC + D + C C PG+ G DC+ CV + CQ+GGTC D
Sbjct: 239 PPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSH--QCQNGGTCQDG-- 294
Query: 150 RASHASCLCPPGFSGNFCEIVANSCT---PNPCENDGVCTDIGGDFRCRCPAGFIDKTCS 206
+CLCP ++G C + C P C N G C + G F C C +G+ +C
Sbjct: 295 -LDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCE 353
Query: 207 RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ +C ++ C G TC+ S+ CLC P TGL C
Sbjct: 354 ENLDDCIAATCAPGSTCIDRVG-SFSCLCPPGRTGLLC 390
Score = 131 bits (329), Expect = 1e-30
Identities = 79/258 (30%), Positives = 112/258 (43%), Gaps = 41/258 (15%)
Query: 25 ECFPACNPQNGFCEDDNV---CRCQPGWQGPLC----DQCVTSPGCLHGLCGE-PGQ--C 74
EC + G C+D C+C PG++GP C D+C++ P + C + PG C
Sbjct: 554 ECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFC 613
Query: 75 ICTDGWDGELCD------------------RDVRAC-------SSAPCANNGTCVSLDDG 109
+C G+ G+LC+ +D C AP +N TC
Sbjct: 614 LCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQ 673
Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
C C G++G +C+ + G C+ +PC HGGTC + S +C CP G++G C
Sbjct: 674 RSSCVCDVGWTGPECEAELGGCI--SAPCAHGGTCYP---QPSGYNCTCPTGYTGPTCSE 728
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV 229
+C PC N G C G + C CP C C S+PC NGGTC+
Sbjct: 729 EMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPG- 787
Query: 230 SYECLCKPEFTGLTCVKK 247
++ CLC F G C K
Sbjct: 788 TFSCLCAMGFQGPRCEGK 805
Score = 127 bits (318), Expect = 2e-29
Identities = 85/271 (31%), Positives = 108/271 (39%), Gaps = 39/271 (14%)
Query: 7 LLRVLLLLLAFGHSTYGAEC--FPACNPQNGFCED----DNVCRCQPGWQGPLC---DQC 57
LL +LLLL G C FP G C C+C PG+ G C D C
Sbjct: 9 LLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPC 68
Query: 58 VTSPGCLHG------------LCGEPGQ------CICTDGWDGELCDRDVR-ACSSAPCA 98
+ C +G L P C C G+ GE C + C + C+
Sbjct: 69 QNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCS 128
Query: 99 NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC 158
G C G +CSC PG++G+ CQ +D + +PC +GG C+ C C
Sbjct: 129 KRGRCHIQASGRPQCSCMPGWTGEQCQLRD---FCSANPCVNGGVCL---ATYPQIQCHC 182
Query: 159 PPGFSGNFCEIVANSC--TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
PPGF G+ CE N C P PC C + G F+C CP G C C
Sbjct: 183 PPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG 242
Query: 217 CQNGGTCL---QHTQVSYECLCKPEFTGLTC 244
C NGGTC + + CLC P F G C
Sbjct: 243 CSNGGTCQLMPEKDSTFHLCLCPPGFIGPDC 273
Score = 123 bits (308), Expect = 3e-28
Identities = 79/226 (34%), Positives = 102/226 (45%), Gaps = 21/226 (9%)
Query: 42 VCRCQPGWQGPLC----DQCVTSPGCLHGLCG-EPG--QCICTDGWDGELCDRDVRACSS 94
+C+C PG+ G C D C + P HG C +PG C C G+ G C+ DV C
Sbjct: 953 LCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLD 1012
Query: 95 APCANNGT--CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
PC GT C SL + Y C C PG++G+ C+ + PC + PC HGGTC G
Sbjct: 1013 QPCHPTGTAACHSLANAFY-CQCLPGHTGQWCEVEIDPC--HSQPCFHGGTCEATAGSPL 1069
Query: 153 HASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI---GGDFRCRCPAGFIDKTCSRPV 209
C CP GF G C A SC + C + G+C G RC C +G+ C P
Sbjct: 1070 GFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPP 1129
Query: 210 T--NCA-SSPCQNGGTCLQHTQV---SYECLCKPEFTGLTCVKKRA 249
C SPC G+C + T + + C C G C K A
Sbjct: 1130 APKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGA 1175
Score = 53.1 bits (126), Expect = 4e-07
Identities = 29/86 (33%), Positives = 36/86 (41%), Gaps = 14/86 (16%)
Query: 176 PNPCENDGVCTDIG-GDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQV----- 229
P PC N G C + G C+C GF+ +TC P + CQNGG+C
Sbjct: 32 PEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91
Query: 230 --------SYECLCKPEFTGLTCVKK 247
S+ C C P FTG C K
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAK 117
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 143 bits (360), Expect = 3e-34
Identities = 81/230 (35%), Positives = 109/230 (47%), Gaps = 22/230 (9%)
Query: 24 AECFPACNPQNGFCEDDNVCRCQPGWQGPLC----DQCVTSP-----GCLHGLCGEPGQC 74
A C A Q+G + C C PG+ G LC D C+ P C+ L G C
Sbjct: 362 ASCIDANEKQDG---SNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFT--C 416
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
C +G+ G C+ V C+S+PC NNGTC +D + C+C+PG++G C + C +
Sbjct: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCY-VDGVHFTCNCSPGFTGPTCAQLIDFCAL- 474
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
SPC HG TC + CLC PG+ G +CE N C PC N C D+ + C
Sbjct: 475 -SPCAHG-TC---RSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYEC 529
Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C A + C CA+ C NG TC ++ C+C P FTG C
Sbjct: 530 VCLAEYKGTHCELYKDPCANVSCLNGATC-DSDGLNGTCICAPGFTGEEC 578
Score = 142 bits (357), Expect = 7e-34
Identities = 74/201 (36%), Positives = 95/201 (47%), Gaps = 24/201 (11%)
Query: 22 YGAECFPACNP-------QNGFCEDDNV---CRCQPGWQGPLCDQ----CVTSPGCLHGL 67
+G+ C +P NG C D V C C PG+ GP C Q C SP C HG
Sbjct: 423 FGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSP-CAHGT 481
Query: 68 CGEPG---QCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC 124
C G +C+C G+ G C+ + C SAPC N TC L +G YEC C Y G C
Sbjct: 482 CRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCLAEYKGTHC 540
Query: 125 QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGV 184
+ PC C +G TC D + +C+C PGF+G C+I N C NPC + G
Sbjct: 541 ELYKDPCA--NVSCLNGATCDSD---GLNGTCICAPGFTGEECDIDINECDSNPCHHGGS 595
Query: 185 CTDIGGDFRCRCPAGFIDKTC 205
C D + C CP G++ C
Sbjct: 596 CLDQPNGYNCHCPHGWVGANC 616
Score = 138 bits (348), Expect = 7e-33
Identities = 72/207 (34%), Positives = 102/207 (49%), Gaps = 12/207 (5%)
Query: 42 VCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNG 101
V C PG +C C C C + + G C+ + AC PC NN
Sbjct: 304 VSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNA 362
Query: 102 TCVSL----DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCL 157
+C+ D + C C PGY+G+ CQ K C+++ PC++G TC+ S +C
Sbjct: 363 SCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILD--PCRNGATCISS---LSGFTCQ 417
Query: 158 CPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPC 217
CP G+ G+ CE + C +PC+N+G C G F C C GF TC++ + CA SPC
Sbjct: 418 CPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC 477
Query: 218 QNGGTCLQHTQVSYECLCKPEFTGLTC 244
+ GTC + SY+CLC P + GL C
Sbjct: 478 AH-GTC-RSVGTSYKCLCDPGYHGLYC 502
Score = 117 bits (292), Expect = 2e-26
Identities = 67/218 (30%), Positives = 99/218 (45%), Gaps = 13/218 (5%)
Query: 97 CANNGTCVSL-DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVD--DEGRASH 153
C+ G C + + + C+C Y G C++ D PCQ+ +C+D ++ S+
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDA---CQRKPCQNNASCIDANEKQDGSN 375
Query: 154 ASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
+C+C PG++G C+ + C +PC N C F C+CP G+ C V CA
Sbjct: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
Query: 214 SSPCQNGGTCLQHTQVSYECLCKPEFTGLTC---VKKRALSPQQVTRLPSGYGLAYR--L 268
SSPCQN GTC V + C C P FTG TC + ALSP S G +Y+
Sbjct: 436 SSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRS-VGTSYKCLC 493
Query: 269 TPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAIC 306
PG H L ++ + L L+ + +C
Sbjct: 494 DPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVC 531
Score = 57.0 bits (136), Expect = 3e-08
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 13/88 (14%)
Query: 92 CSSAPCANNGTCVS-----------LDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
C++ PC N G C S + Y C+C G SG +CQ PC N PC H
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN--PCHH 105
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCE 168
G + C+C G+ G CE
Sbjct: 106 GNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 52.4 bits (124), Expect = 7e-07
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 16/92 (17%)
Query: 129 GPCVINGSPCQHGGTCVD-DEGRASHA--------SCLCPPGFSGNFCEIVANSCTPNPC 179
GPC PC++GG C E H SC CP G SG C++VA+ C NPC
Sbjct: 46 GPCA--AQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC 103
Query: 180 ENDGVCTDIGGD----FRCRCPAGFIDKTCSR 207
+ G C+ + C C G+ C +
Sbjct: 104 HH-GNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 50.8 bits (120), Expect = 2e-06
Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 24/111 (21%)
Query: 174 CTPNPCENDGVCTDI----------GGD--FRCRCPAGFIDKTCSRPVTNCASSPCQNGG 221
C PC N GVCT G+ + C CPAG C CAS+PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 222 TCLQHTQVS--YECLCKPEFTGLTCVK----------KRALSPQQVTRLPS 260
+ S Y C+C + G C + +++P+Q+ +P+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPA 158
Score = 44.7 bits (104), Expect = 1e-04
Identities = 30/89 (33%), Positives = 37/89 (41%), Gaps = 7/89 (7%)
Query: 43 CRCQPGWQGPLCDQCVTSPGCLHGLCGEPG-QCICTDGWDGELCDRDVRACSSAPCANNG 101
C QP G +C GEPG C C G G C C+S PC ++G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
Query: 102 TC----VSLDDGLYECSCAPGYSGKDCQK 126
C S DG Y C C GY G +C++
Sbjct: 107 NCSSSSSSSSDG-YLCICNEGYEGPNCEQ 134
Score = 29.6 bits (65), Expect = 4.8
Identities = 10/31 (32%), Positives = 17/31 (54%)
Query: 30 CNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS 60
C+ + D +C C G++GP C+Q + S
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPS 138
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 142 bits (357), Expect = 7e-34
Identities = 75/199 (37%), Positives = 95/199 (47%), Gaps = 21/199 (10%)
Query: 51 GPLCDQCVTSPGCLHGLCGEPGQ-CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDG 109
G D CVT G P C C G+ G C DV C+S PC N GTC
Sbjct: 282 GKCIDDCVT---------GNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTH-GIN 331
Query: 110 LYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI 169
+ C C G+ G C+ PC + CQHGG C + G A C+C G++G CE+
Sbjct: 332 SFRCQCPAGFGGPTCETAQSPC--DTKECQHGGQCQVENG---SAVCVCQAGYTGAACEM 386
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC---SRPVTN-CASSPCQNGGTCLQ 225
+ C+P+PC N G C D+ G++ C C F C PV + C S+PC NGGTC+
Sbjct: 387 DVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVD 446
Query: 226 HTQVSYECLCKPEFTGLTC 244
Q Y C C F GL C
Sbjct: 447 ADQ-GYVCECPEGFMGLDC 464
Score = 135 bits (341), Expect = 5e-32
Identities = 78/227 (34%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 30 CNPQNG---FCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGELC 85
C +NG + +C+C G+ G LC+ +T+ C ++ C + G C+ G +C
Sbjct: 472 CECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVC 531
Query: 86 DRDVRA-------CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
D A C S PC N G+C + DD Y C C G+ GK C+K P + + PC
Sbjct: 532 HTDHNASHSLPSPCDSDPCFNGGSCDAHDDS-YTCECPRGFHGKHCEKAR-PHLCSSGPC 589
Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFCEI-VANSCTPNPCENDGVCTDIGGDFRCRCP 197
++GGTC + G C CP F+G CEI +SC PC N G C G ++C CP
Sbjct: 590 RNGGTCKEAGGEYH---CSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCP 646
Query: 198 AGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
GF + C + C SPC NGGTC + + C C+ + G C
Sbjct: 647 PGFSGRHCEIAPSPCFRSPCVNGGTC-EDRDTDFFCHCQAGYMGRRC 692
Score = 126 bits (316), Expect = 4e-29
Identities = 87/234 (37%), Positives = 110/234 (47%), Gaps = 35/234 (14%)
Query: 35 GFCEDDN---VCRCQPGWQGPLC----DQCVTSPGCLHG-----LCGEPGQCICTDGWDG 82
G C+ +N VC CQ G+ G C D C P CL+G L G C+C + + G
Sbjct: 362 GQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDP-CLNGGSCVDLVGN-YTCLCAEPFKG 419
Query: 83 ELCDRDVR----ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC 138
C+ AC SAPC N GTCV D G Y C C G+ G DC+++ V + C
Sbjct: 420 LRCETGDHPVPDACLSAPCHNGGTCVDADQG-YVCECPEGFMGLDCRER----VPDDCEC 474
Query: 139 QHGGTCVDDEGRASHASCLCPPGFSGNFC--EIVANSCTPN-PCENDGVCTDIGGDFRCR 195
++GG C+ A+ C CP GF G C EI A C N C + G C + GG + C
Sbjct: 475 RNGGRCLG----ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCV 530
Query: 196 CPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
C D S + + C S PC NGG+C H SY C C F G C K R
Sbjct: 531 C---HTDHNASHSLPSPCDSDPCFNGGSCDAHDD-SYTCECPRGFHGKHCEKAR 580
Score = 121 bits (304), Expect = 9e-28
Identities = 78/266 (29%), Positives = 102/266 (38%), Gaps = 69/266 (25%)
Query: 43 CRCQPGWQGPLC-----DQCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSS 94
C C + G C D C + P G C +C C G+ G C+ C
Sbjct: 604 CSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFR 663
Query: 95 APCANNGTCVSLDDGLYECSCAPGYSGK------DC----QKKDGPCVINGS-------- 136
+PC N GTC D + C C GY G+ DC + K NG+
Sbjct: 664 SPCVNGGTCEDRDTDFF-CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALY 722
Query: 137 --------------------------------------PCQHGGTCVDDEGRASHASCLC 158
PC HGG+C D R + CLC
Sbjct: 723 ACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQD---RVAGYLCLC 779
Query: 159 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ 218
G+ G CE+ + C +PC N G C ++ G + CRCPAGF+ C V C SSPCQ
Sbjct: 780 STGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQ 839
Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTC 244
+GG C + +Y C+C F G C
Sbjct: 840 HGGRC-ESGGGAYLCVCPESFFGYHC 864
Score = 120 bits (302), Expect = 2e-27
Identities = 72/233 (30%), Positives = 98/233 (42%), Gaps = 36/233 (15%)
Query: 15 LAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQC 74
L F + GA AC+ + CQP HG+ EP QC
Sbjct: 709 LRFNGTRLGAVALYACDRGYSLSAPSRIRVCQP-----------------HGVWSEPPQC 751
Query: 75 ICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
+ ++ C S PC + G+C G Y C C+ GY G C+ + C
Sbjct: 752 L------------EIDECRSQPCLHGGSCQDRVAG-YLCLCSTGYEGAHCELERDEC--R 796
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRC 194
PC++GG+C + G C CP GF G CE ++C +PC++ G C GG + C
Sbjct: 797 AHPCRNGGSCRNLPGAYV---CRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLC 853
Query: 195 RCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
CP F C C SSPC G CL + S+ C CK +TG C K+
Sbjct: 854 VCPESFFGYHCETVSDPCFSSPCGGRGYCLA-SNGSHSCTCKVGYTGEDCAKE 905
Score = 112 bits (279), Expect = 7e-25
Identities = 56/164 (34%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 85 CDRDVRACSSA-PCANNGTCVS---LDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH 140
C C + PC N G C+ + Y CSC G++G+ C C PCQ+
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECA--SQPCQN 322
Query: 141 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF 200
GGTC + C CP GF G CE + C C++ G C G C C AG+
Sbjct: 323 GGTCTHG---INSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGY 379
Query: 201 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C V +C+ PC NGG+C+ +Y CLC F GL C
Sbjct: 380 TGAACEMDVDDCSPDPCLNGGSCVDLVG-NYTCLCAEPFKGLRC 422
Score = 106 bits (265), Expect = 3e-23
Identities = 81/285 (28%), Positives = 104/285 (36%), Gaps = 75/285 (26%)
Query: 32 PQNGFCEDDN-----VCRCQPGWQGPLCDQCVTSPGCLHGLCG---EPGQCICTDGWDGE 83
P G+C + VC L C + P G C + C C G+ G+
Sbjct: 515 PDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGK 574
Query: 84 LCDRD-VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHG 141
C++ CSS PC N GTC G Y CSC ++G+ C+ K C PC +G
Sbjct: 575 HCEKARPHLCSSGPCRNGGTCKEAG-GEYHCSCPYRFTGRHCEIGKPDSCA--SGPCHNG 631
Query: 142 GTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDF--------- 192
GTC G+ C CPPGFSG CEI + C +PC N G C D DF
Sbjct: 632 GTCFHYIGKYK---CDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYM 688
Query: 193 --RCR------------------------------CPAGFIDKTCSR------------- 207
RC+ C G+ SR
Sbjct: 689 GRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEP 748
Query: 208 ----PVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKR 248
+ C S PC +GG+C Q Y CLC + G C +R
Sbjct: 749 PQCLEIDECRSQPCLHGGSC-QDRVAGYLCLCSTGYEGAHCELER 792
Score = 46.2 bits (108), Expect = 5e-05
Identities = 28/63 (44%), Positives = 33/63 (52%), Gaps = 9/63 (14%)
Query: 117 PGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEI----VAN 172
P + KD G C N PCQ+GGTCV G +H SC C PGF G CE+ V+
Sbjct: 1297 PEHGSKDIGNVPGNCSEN--PCQNGGTCVP--GADAH-SCDCGPGFKGRRCELACIKVSR 1351
Query: 173 SCT 175
CT
Sbjct: 1352 PCT 1354
Score = 44.7 bits (104), Expect = 1e-04
Identities = 23/62 (37%), Positives = 27/62 (43%), Gaps = 10/62 (16%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQ----KKDGPCV-----INGSPCQHGG 142
CS PC N GTCV D + C C PG+ G+ C+ K PC P GG
Sbjct: 1311 CSENPCQNGGTCVPGADA-HSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 143 TC 144
C
Sbjct: 1370 VC 1371
Score = 40.0 bits (92), Expect = 0.004
Identities = 27/92 (29%), Positives = 36/92 (39%), Gaps = 14/92 (15%)
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC-------SRPVTNCASS----PCQ 218
V +C+ NPC+N G C C C GF + C SRP T S P
Sbjct: 1307 VPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVW 1366
Query: 219 NGGTC---LQHTQVSYECLCKPEFTGLTCVKK 247
GG C + ++ +C E T +KK
Sbjct: 1367 EGGVCHHVYKRVYRVHQDICFKESCESTSLKK 1398
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 140 bits (352), Expect = 2e-33
Identities = 74/207 (35%), Positives = 99/207 (47%), Gaps = 17/207 (8%)
Query: 43 CRCQPGWQGPLC--------DQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVR--AC 92
C+C G+ G C ++C C+ C C G+ GE C
Sbjct: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCF 71
Query: 93 SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
S PC N GTC L YEC+C G++GK+CQ D C+ + PC +G TC A+
Sbjct: 72 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSH--PCANGSTCTTV---AN 125
Query: 153 HASCLCPPGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
SC C GF+G CE N C P C++ G C ++ G ++C+C GF + C
Sbjct: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPE 238
CA SPC NGGTC Q ++EC C PE
Sbjct: 186 CAPSPCVNGGTCRQTGDFTFECNCLPE 212
Score = 120 bits (301), Expect = 2e-27
Identities = 69/177 (38%), Positives = 91/177 (51%), Gaps = 11/177 (6%)
Query: 72 GQCICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDD-GLYECSCAPGYSGKDCQKKDG 129
G C C +G+ GE C RD C C N GTCV+ G C CA G++G+DCQ
Sbjct: 10 GYCKCPEGFLGEYCQHRD--PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
Query: 130 -PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI 188
PC ++ PC +GGTC R ++ C C GF+G C+ ++C +PC N CT +
Sbjct: 68 HPCFVS-RPCLNGGTC-HMLSRDTY-ECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123
Query: 189 GGDFRCRCPAGFIDKTCSRPVTNC-ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
F C+C GF + C V C CQ+GGTCL + SY+C C FTG C
Sbjct: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCL-NLPGSYQCQCLQGFTGQYC 179
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 135 bits (341), Expect = 5e-32
Identities = 89/250 (35%), Positives = 118/250 (47%), Gaps = 35/250 (14%)
Query: 24 AECFPAC-NP--QNGFCEDDNV----CRCQPGWQGPLCD----QCVTSPGCLHG-LC--- 68
A+C P NP +G C D V C C G++G CD C+++P C HG C
Sbjct: 917 AKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNP-CKHGGTCHLK 975
Query: 69 -GEPGQ--CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKD 123
GE CIC DG++GE C+ +V C C NN TCV DG+ Y C C P Y+G+
Sbjct: 976 EGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCV---DGINNYTCLCPPEYTGEL 1032
Query: 124 CQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDG 183
C++K C + +PCQH C+ C C PG+ G C+I + C N C+N
Sbjct: 1033 CEEKLDFCAQDLNPCQHDSKCILTP---KGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGA 1089
Query: 184 VCTDIGGDFRCRCPAGFIDKTC--SRPVTNCASSP-----CQNGGTCLQHTQVSYECLCK 236
CTD + C CP G+ C S P+ +SP CQNG C+ C C
Sbjct: 1090 HCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPI-CQCL 1148
Query: 237 PEFTGLTCVK 246
P + G C K
Sbjct: 1149 PGYQGEKCEK 1158
Score = 94.0 bits (232), Expect = 2e-19
Identities = 57/183 (31%), Positives = 81/183 (44%), Gaps = 12/183 (6%)
Query: 71 PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVS---LDDGLYECSCAPGYSGKDCQKK 127
P C C W + + + A CA G L + +C G + K
Sbjct: 860 PLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQ-GPVDVNILAK 918
Query: 128 DGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
PC+ N PC++ GTC D C CP GF G C++ ++C NPC++ G C
Sbjct: 919 CNPCLSN--PCKNDGTCNSDP--VDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHL 974
Query: 188 IGGD---FRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
G+ F C C GF + C V +C + C+N TC+ +Y CLC PE+TG C
Sbjct: 975 KEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGIN-NYTCLCPPEYTGELC 1033
Query: 245 VKK 247
+K
Sbjct: 1034 EEK 1036
Score = 67.4 bits (163), Expect = 2e-11
Identities = 39/121 (32%), Positives = 51/121 (42%), Gaps = 22/121 (18%)
Query: 28 PACNP------QNGFCEDDN----VCRCQPGWQGPLCDQCVTSP----GCLHGLC----G 69
P C P +G C+ + C CQ GW GPLCDQ P C+HG C
Sbjct: 1331 PGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINA 1390
Query: 70 EPGQCICTDGWDGELCDRD---VRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK 126
C C +G G LCD + C + C +G C G C C+ GY+G C +
Sbjct: 1391 FSYSCKCLEGHGGVLCDEEEDLFNPCQAIKC-KHGKCRLSGLGQPYCECSSGYTGDSCDR 1449
Query: 127 K 127
+
Sbjct: 1450 E 1450
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/205 (25%), Positives = 79/205 (38%), Gaps = 32/205 (15%)
Query: 52 PLCDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANN----GTC 103
P C+ C C HG C Q C C +GW G LCD+ ++ PC N GTC
Sbjct: 1331 PGCEPCHKKV-CAHGTCQPSSQAGFTCECQEGWMGPLCDQR----TNDPCLGNKCVHGTC 1385
Query: 104 VSLDDGLYECSCAPGYSGKDCQKKD---GPCVINGSPCQHGGTCVDDEGRASHASCLCPP 160
+ ++ Y C C G+ G C +++ PC C+HG + G+ C C
Sbjct: 1386 LPINAFSYSCKCLEGHGGVLCDEEEDLFNPC--QAIKCKHGKCRLSGLGQ---PYCECSS 1440
Query: 161 GFSGNFCEIVANSCTPNPC-------ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCA 213
G++G+ C+ SC + C R C G C P+ +
Sbjct: 1441 GYTGDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKR 1499
Query: 214 ---SSPCQNGGTCLQHTQVSYECLC 235
S C +G + + + +C C
Sbjct: 1500 RKYSFECTDGSSFVDEVEKVVKCGC 1524
Score = 36.2 bits (82), Expect = 0.051
Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 3/72 (4%)
Query: 192 FRCRCPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRAL 250
F C C G++ C + + C + C +G TCL SY C C G+ C ++ L
Sbjct: 1354 FTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLEGHGGVLCDEEEDL 1412
Query: 251 -SPQQVTRLPSG 261
+P Q + G
Sbjct: 1413 FNPCQAIKCKHG 1424
Score = 28.9 bits (63), Expect = 8.1
Identities = 12/37 (32%), Positives = 20/37 (54%), Gaps = 8/37 (21%)
Query: 23 GAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVT 59
GA+C N + +C+C PG+QG C++ V+
Sbjct: 1133 GAQCIVRIN--------EPICQCLPGYQGEKCEKLVS 1161
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 135 bits (340), Expect = 6e-32
Identities = 69/199 (34%), Positives = 96/199 (48%), Gaps = 14/199 (7%)
Query: 54 CDQCVTSPGCLHGLCG----EPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD-- 107
CD C++SP G C E +C C G+ G C+ + +CSS PC N GTC + +
Sbjct: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGE 985
Query: 108 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC 167
D + CSC G+ G C CV + C +GG CVD G + +C CP + G C
Sbjct: 986 DAPFTCSCPTGFEGPTCGVNTDDCVDHA--CANGGVCVDGVG---NYTCQCPLQYEGKAC 1040
Query: 168 EIVANSCTP--NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQ 225
E + + C+P NPC+++ C RC C G+ CS +C CQNG C+
Sbjct: 1041 EQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMD 1100
Query: 226 HTQVSYECLCKPEFTGLTC 244
SY CLC ++G C
Sbjct: 1101 EVN-SYSCLCAEGYSGQLC 1118
Score = 121 bits (303), Expect = 1e-27
Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 25/241 (10%)
Query: 26 CFPACNPQNGFCEDDNV----CRCQPGWQGPLC----DQCVTSP----GCLHGLCGE--P 71
C + G C +D + C C G++G C D C + P G H GE P
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
Query: 72 GQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPC 131
C C G++G C + C CAN G CV G Y C C Y GK C++ C
Sbjct: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVD-GVGNYTCQCPLQYEGKACEQLVDLC 1047
Query: 132 VINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGD 191
+ +PCQH CV G C C PG++G+ C + C + C+N C D
Sbjct: 1048 SPDLNPCQHEAQCV---GTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS 1104
Query: 192 FRCRCPAGFIDKTCS------RPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCV 245
+ C C G+ + C P + C + CQNG C+ C C P F G C
Sbjct: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPV-CQCLPGFGGPECE 1163
Query: 246 K 246
K
Sbjct: 1164 K 1164
Score = 78.6 bits (192), Expect = 9e-15
Identities = 69/214 (32%), Positives = 90/214 (42%), Gaps = 35/214 (16%)
Query: 34 NGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLC---GEPG-QCICTDGWDGELCDRDV 89
N +D + +PG P C+ C CLHG+C PG C C GW G CD+
Sbjct: 1320 NNELQDFTKTQMKPGVV-PGCEPC-RKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPA 1377
Query: 90 RA-CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDG---PCVINGSPCQHGGTCV 145
C C + G CV LD Y C C GYSG C + PC G C H G C
Sbjct: 1378 DGPCHGHKCVH-GQCVPLDALSYSCQCQDGYSGALCNQAGALAEPC--RGLQCLH-GHCQ 1433
Query: 146 DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
+ +H C+C PGFSG CE + C D V DF + G+
Sbjct: 1434 ASGTKGAH--CVCDPGFSGELCE------QESECRGDPV-----RDFH-QVQRGYAICQT 1479
Query: 206 SRPVT--NCASSPCQNGGTC----LQHTQVSYEC 233
+RP++ C S C G C L+ + ++EC
Sbjct: 1480 TRPLSWVECRGS-CPGQGCCQGLRLKRRKFTFEC 1512
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/133 (29%), Positives = 47/133 (35%), Gaps = 42/133 (31%)
Query: 113 CSCAPGYSGKDC-QKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
C C G+ G C Q DGPC +G C HG CV + A SC C G+SG C
Sbjct: 1362 CHCEAGWVGLHCDQPADGPC--HGHKCVHG-QCVPLD--ALSYSCQCQDGYSGALCN--- 1413
Query: 172 NSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSY 231
AG + + C C CQ GT H
Sbjct: 1414 -------------------------QAGALAEPCRG--LQCLHGHCQASGTKGAH----- 1441
Query: 232 ECLCKPEFTGLTC 244
C+C P F+G C
Sbjct: 1442 -CVCDPGFSGELC 1453
Score = 38.1 bits (87), Expect = 0.013
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 194 CRCPAGFIDKTCSRPVTN-CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALS 251
C C AG++ C +P C C +G C+ +SY C C+ ++G C + AL+
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQDGYSGALCNQAGALA 1419
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 125 bits (315), Expect = 5e-29
Identities = 59/156 (37%), Positives = 77/156 (49%), Gaps = 5/156 (3%)
Query: 91 ACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGR 150
AC S+PC NNGTC LY C+C Y GKDC C+ N PCQHGGTC +
Sbjct: 919 ACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQN--PCQHGGTCHLSDSH 976
Query: 151 ASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT 210
SC CP GF G CEI + C N CEN+ C D ++ C CP + + C +
Sbjct: 977 KDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
Query: 211 NCAS--SPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+C + CQ+ C+ + C C P ++G C
Sbjct: 1037 HCVPELNLCQHEAKCIP-LDKGFSCECVPGYSGKLC 1071
Score = 125 bits (313), Expect = 8e-29
Identities = 79/246 (32%), Positives = 105/246 (42%), Gaps = 34/246 (13%)
Query: 26 CFPACNPQNGFCEDDNV----CRCQPGWQGPLC----DQCVTSPGCLHG-LCG------E 70
C + NG C D V C C ++G C + C+ +P C HG C +
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNP-CQHGGTCHLSDSHKD 978
Query: 71 PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQKKD 128
C C G++G+ C+ + C C NN TCV DG+ Y C C P Y+G+ C +
Sbjct: 979 GFSCSCPLGFEGQRCEINPDDCEDNDCENNATCV---DGINNYVCICPPNYTGELCDEVI 1035
Query: 129 GPCVINGSPCQHGGTCVD-DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTD 187
CV + CQH C+ D+G SC C PG+SG CE + C + C + C D
Sbjct: 1036 DHCVPELNLCQHEAKCIPLDKG----FSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
Query: 188 IGGDFRCRCPAGFIDKTCSRP-------VTNCASSPCQNGGTCLQHTQVSYECLCKPEFT 240
+ C CP GF C P + C CQNG C+ Q C C P F
Sbjct: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIV-VQQEPTCRCPPGFA 1150
Query: 241 GLTCVK 246
G C K
Sbjct: 1151 GPRCEK 1156
Score = 113 bits (282), Expect = 3e-25
Identities = 65/207 (31%), Positives = 94/207 (45%), Gaps = 31/207 (14%)
Query: 22 YGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD---------QCVTSPGCLHGLCGEPG 72
+G C + + ++GF C C G++G C+ C + C+ G+
Sbjct: 966 HGGTCHLSDSHKDGFS-----CSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYV- 1019
Query: 73 QCICTDGWDGELCDRDVRACSSAP--CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGP 130
CIC + GELCD + C C + C+ LD G + C C PGYSGK C+ +
Sbjct: 1020 -CICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDD 1077
Query: 131 CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCE-------IVANSCTPNPCENDG 183
CV + C+HG CVD + +C CP GFSG FCE + + C C+N
Sbjct: 1078 CVAH--KCRHGAQCVDT---INGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132
Query: 184 VCTDIGGDFRCRCPAGFIDKTCSRPVT 210
C + + CRCP GF C + +T
Sbjct: 1133 QCIVVQQEPTCRCPPGFAGPRCEKLIT 1159
Score = 86.7 bits (213), Expect = 3e-17
Identities = 46/114 (40%), Positives = 61/114 (53%), Gaps = 16/114 (14%)
Query: 33 QNGFC----EDDNVCRCQPGWQGPLCDQCVTSP----GCLHGLC---GEPGQCICTDGWD 81
++G C +D VC C+PGW GPLCDQ P C HG C G C C +G+
Sbjct: 1339 KHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYG 1398
Query: 82 GELCDR---DVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCV 132
G+LCD ACS+ C ++G C D G C C PG+SG+ CQ ++ PC+
Sbjct: 1399 GDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCL 1450
Score = 65.5 bits (158), Expect = 8e-11
Identities = 29/76 (38%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 172 NSCTPNPCENDGVCT-DIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC--LQHTQ 228
N+C +PC+N+G CT D +RC CP + K C+ P+ C +PCQ+GGTC +
Sbjct: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
Query: 229 VSYECLCKPEFTGLTC 244
+ C C F G C
Sbjct: 978 DGFSCSCPLGFEGQRC 993
Score = 57.4 bits (137), Expect = 2e-08
Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 10/120 (8%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDC-QKKDGPCVINGSPCQHGGTCVDDEGR 150
C S +G C S++ C C PG++G C Q+ PC+ G C H G CV
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL--GHRCHH-GKCV---AT 1385
Query: 151 ASHASCLCPPGFSGNFCE---IVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR 207
+ C C G+ G+ C+ AN+C+ C + G+ C C GF + C +
Sbjct: 1386 GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/132 (28%), Positives = 55/132 (41%), Gaps = 12/132 (9%)
Query: 138 CQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANS-CTPNPCENDGVCTDIGGDFRCRC 196
C+HG C E C C PG++G C+ A C + C + G C G + C+C
Sbjct: 1338 CKHG-LCRSVE--KDSVVCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKC 1393
Query: 197 PAGFIDKTCSRP---VTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
G+ C C++ C +G C Q CLC+P F+G C ++ Q
Sbjct: 1394 AEGYGGDLCDNKNDSANACSAFKCHHG-QCHISDQGEPYCLCQPGFSGEHCQQENPCLGQ 1452
Query: 254 ---QVTRLPSGY 262
+V R GY
Sbjct: 1453 VVREVIRRQKGY 1464
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 117 bits (294), Expect = 1e-26
Identities = 71/217 (32%), Positives = 98/217 (45%), Gaps = 38/217 (17%)
Query: 35 GFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCICTDGWDGELCDRDVRACS 93
G C ++C+C+PGW GP C + P CL+ G C +P C+C +G+ GE C A
Sbjct: 1402 GQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQ---NAFC 1458
Query: 94 SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH 153
PC N G C+ + C C GY+G+ QK I C +GG CV
Sbjct: 1459 HPPCKNGGHCMRNN----VCVCREGYTGRRFQKS-----ICDPTCMNGGKCV------GP 1503
Query: 154 ASCLCPPGFSGNFCEIVANSCTP---NPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT 210
++C CP G+SG C TP C+N G C C CP+ + C P+
Sbjct: 1504 STCSCPSGWSGKRCN------TPICLQKCKNGGECI---APSICHCPSSWEGVRCQIPIC 1554
Query: 211 NCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
N C GG C+ C C+ E++G+ C KK
Sbjct: 1555 N---PKCLYGGRCI----FPNVCSCRTEYSGVKCEKK 1584
Score = 104 bits (259), Expect = 2e-22
Identities = 62/206 (30%), Positives = 93/206 (45%), Gaps = 32/206 (15%)
Query: 37 CEDDNVCRCQPGWQGPLCDQCVTSPGCL-HGLCGEPGQCICTDGWDGELCDRDVRACSSA 95
C N+C+C+PG+ G C + P C HG C +P C C G G CD + +
Sbjct: 1308 CVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDEE---HCNP 1364
Query: 96 PCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS 155
PC + GTC++ + C+C G+ G C+ ++ C++GG C+ +
Sbjct: 1365 PCQHGGTCLAGN----LCTCPYGFVGPRCE-----TMVCNRHCENGGQCLTPD------I 1409
Query: 156 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS 215
C C PG+ G C C P C N G C C CP GF + C +
Sbjct: 1410 CQCKPGWYGPTCSTAL--CDP-VCLNGGSCNKPN---TCLCPNGFFGEHCQNAFCH---P 1460
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTG 241
PC+NGG C+++ C+C+ +TG
Sbjct: 1461 PCKNGGHCMRNN----VCVCREGYTG 1482
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/257 (25%), Positives = 83/257 (32%), Gaps = 82/257 (31%)
Query: 54 CDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDG 109
CD C+ C+ PG C+C G+ G LC+ D+ C S PC
Sbjct: 1181 CD-CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGFHS- 1238
Query: 110 LYECSCAPGY-------------------SGKDCQKKDGPCVINGS-------------- 136
Y C C P S K K++ G
Sbjct: 1239 -YSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTI 1297
Query: 137 ---PCQHGGTCVD--------------------DEGRASHASCL------CPPGFSGNFC 167
PC CV D +H C+ C PG G C
Sbjct: 1298 CKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATC 1357
Query: 168 EIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT 227
+ C P PC++ G C + G+ C CP GF+ C V N C+NGG CL
Sbjct: 1358 D--EEHCNP-PCQHGGTC--LAGNL-CTCPYGFVGPRCETMVCN---RHCENGGQCL--- 1405
Query: 228 QVSYECLCKPEFTGLTC 244
C CKP + G TC
Sbjct: 1406 -TPDICQCKPGWYGPTC 1421
Score = 50.8 bits (120), Expect = 2e-06
Identities = 55/215 (25%), Positives = 74/215 (34%), Gaps = 58/215 (26%)
Query: 85 CDRDVRAC-----SSAPCANNGTCVS-----LDDGLYECSCAPGYSGKDCQKKDGPCVIN 134
CD + R S C N G+CVS G+Y C C PG+ G C+ C N
Sbjct: 1166 CDAETRVTIEVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSN 1225
Query: 135 GSPCQHGGTCVDDEGRASHASCLCPP----------GFSGNFCEIVANSCTPNPCEND-- 182
PC G G S+ SC CPP F+ + + + N E+D
Sbjct: 1226 --PCGLGSYI---SGFHSY-SCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKN 1279
Query: 183 ----------------GVCTDIGGDFR-------CRCPAGFIDKTCSRPVTNCASSPCQN 219
+C G R C+C G+I C T C+N
Sbjct: 1280 AQGRKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQ---TALCDPDCKN 1336
Query: 220 GGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQ 254
G C++ C C P G TC ++ P Q
Sbjct: 1337 HGKCIKPN----ICQCLPGHGGATCDEEHCNPPCQ 1367
Score = 43.9 bits (102), Expect = 2e-04
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Query: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHG-LCGEPGQCICTDGWDGEL 84
C C G C ++C C W+G C + +P CL+G C P C C + G
Sbjct: 1522 CLQKCK-NGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVK 1580
Query: 85 CDRDVR 90
C++ ++
Sbjct: 1581 CEKKIQ 1586
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 117 bits (294), Expect = 1e-26
Identities = 89/269 (33%), Positives = 107/269 (39%), Gaps = 55/269 (20%)
Query: 21 TYGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCD----------QCVTSPGCLH--G 66
T+G C C NG C D C C PGW+G C+ C C H G
Sbjct: 490 TWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADG 549
Query: 67 LCGEPGQCICTDGWDGELCDRDVRACS--------SAPC-ANNGTCVSLDDGLYECSCAP 117
G C C GW G CD C+ S PC NG S DDG+ C CAP
Sbjct: 550 CHPTTGHCRCLPGWSGVHCDS---VCAEGRWGPNCSLPCYCKNGASCSPDDGI--CECAP 604
Query: 118 GYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIV----- 170
G+ G CQ+ P Q CV G H + C C PGF+G C V
Sbjct: 605 GFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGR 664
Query: 171 -----ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV------TNCA-SSPCQ 218
A CT C N+G C I D C+C G+I CS+P NC + C
Sbjct: 665 FGKNCAGICT---CTNNGTCNPI--DRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCH 719
Query: 219 NGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
NG C + EC C P +TGL C ++
Sbjct: 720 NGAFC---SAYDGECKCTPGWTGLYCTQR 745
Score = 111 bits (278), Expect = 1e-24
Identities = 84/268 (31%), Positives = 110/268 (41%), Gaps = 58/268 (21%)
Query: 21 TYGAECFPACNPQNGFCED--DNVCRCQPGWQGPLCD----------QCVTSPGCLH-GL 67
TYG +C C QNG D CRC PG+ G C+ QC C + G+
Sbjct: 186 TYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGV 245
Query: 68 CGE-PGQCICTDGWDGELC------DRDVRACS-SAPCANNGTCVSLDDGLYECSCAPGY 119
C G+C C GW G +C R + CS C N GTC D +C C+PGY
Sbjct: 246 CHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC---DAATGQCHCSPGY 302
Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCE--------- 168
+G+ CQ + P G C CV+ G+ H S CLC GF+G CE
Sbjct: 303 TGERCQ-DECPVGTYGVLCAETCQCVNG-GKCYHVSGACLCEAGFAGERCEARLCPEGLY 360
Query: 169 -IVANSCTPNPCENDGVCTDIGGDFRCR-----------CPAGFIDKTCSRPVTNCASSP 216
I + P EN C + G+ C+ C GF + C + +
Sbjct: 361 GIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICS------ 414
Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTC 244
CQNG C V+ +C C P F G+ C
Sbjct: 415 CQNGADC---DSVTGKCTCAPGFKGIDC 439
Score = 108 bits (271), Expect = 6e-24
Identities = 74/233 (31%), Positives = 97/233 (41%), Gaps = 50/233 (21%)
Query: 44 RCQPGW--QGPLC-DQCVTSPGCLHGLCGEPGQCICTDGWDG----ELCDRD---VRACS 93
+C PG+ G +C C C+HG C P C C GW G CD D S
Sbjct: 93 QCCPGFYESGEMCVPHCADK--CVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTS 150
Query: 94 SAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKK-----DGPCVINGSPCQHGGTCVDDE 148
C N C + C CA G+ G C+ + G CQ+G TC
Sbjct: 151 RCQCKNGALCNPITGA---CHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVT 207
Query: 149 GRASHASCLCPPGFSGNFCEIVANSCTPN----------PCENDGVCTDIGGDFRCRCPA 198
G C CPPG++G FCE + C P PC+N GVC + G+ C CP+
Sbjct: 208 G-----ECRCPPGYTGAFCE---DLCPPGKHGPQCEQRCPCQNGGVCHHVTGE--CSCPS 257
Query: 199 GFIDKTCSRPV------TNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
G++ C +P NC+ C NGGTC + +C C P +TG C
Sbjct: 258 GWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC---DAATGQCHCSPGYTGERC 307
Score = 104 bits (259), Expect = 2e-22
Identities = 82/262 (31%), Positives = 99/262 (37%), Gaps = 53/262 (20%)
Query: 23 GAECFPACNPQ--NGFCEDDNVCRCQPGWQGPLCD----------QCVTSPGCLHGLCGE 70
G C P C + +G C N C+C+PGW G C C + C +G
Sbjct: 102 GEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRCQCKNGALCN 161
Query: 71 P--GQCICTDGWDGELC-DRDVRAC------SSAPCANNGTCVSLDDGLYECSCAPGYSG 121
P G C C G+ G C DR + C N TC D EC C PGY+G
Sbjct: 162 PITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATC---DHVTGECRCPPGYTG 218
Query: 122 KDCQK-----KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC-------EI 169
C+ K GP PCQ+GG C G C CP G+ G C
Sbjct: 219 AFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTG-----ECSCPSGWMGTVCGQPCPEGRF 273
Query: 170 VANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR--PVTN----CASS-PCQNGGT 222
N C N G C G +C C G+ + C PV CA + C NGG
Sbjct: 274 GKNCSQECQCHNGGTCDAATG--QCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGK 331
Query: 223 CLQHTQVSYECLCKPEFTGLTC 244
C VS CLC+ F G C
Sbjct: 332 CY---HVSGACLCEAGFAGERC 350
Score = 80.1 bits (196), Expect = 3e-15
Identities = 71/265 (26%), Positives = 93/265 (35%), Gaps = 52/265 (19%)
Query: 21 TYGAECFPACNPQNG--FCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGE-------- 70
TYG C C NG C C+ G+ G C+ + G C +
Sbjct: 315 TYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLEN 374
Query: 71 -------PGQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCA 116
G+C C GW G C+ AC C N C S+ +C+CA
Sbjct: 375 THSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTG---KCTCA 431
Query: 117 PGYSGKDCQKKDGPCVIN--GSPCQHGGTCVDDEGRAS-HASCLCPPGFSGNFCEIVANS 173
PG+ G DC PC + G C C +D + SC C G+ G C I S
Sbjct: 432 PGFKGIDCST---PCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPS 488
Query: 174 CT-------PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPV------TNCAS-SPCQN 219
T C N G C + G C C G+ + C P NCA C +
Sbjct: 489 GTWGFGCNLTCQCLNGGACNTLDG--TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSH 546
Query: 220 GGTCLQHTQVSYECLCKPEFTGLTC 244
C T C C P ++G+ C
Sbjct: 547 ADGCHPTTG---HCRCLPGWSGVHC 568
Score = 68.9 bits (167), Expect = 7e-12
Identities = 49/170 (28%), Positives = 71/170 (41%), Gaps = 28/170 (16%)
Query: 22 YGAECFPACN-PQNGFCED-DNVCRCQPGWQGPLCDQ-CVTS---PGCLH-------GLC 68
+G C C NG C D C+C PGW G C Q C + P C+H C
Sbjct: 665 FGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFC 724
Query: 69 GE-PGQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCAPGYS 120
G+C CT GW G C + + C+ C N C + +C+C G+
Sbjct: 725 SAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISG---QCTCRTGFM 781
Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH--ASCLCPPGFSGNFCE 168
G+ C++K P G C+ C+++ H +C C PG+ G C+
Sbjct: 782 GRHCEQK-CPSGTYGYGCRQICDCLNN-STCDHITGTCYCSPGWKGARCD 829
Score = 60.5 bits (145), Expect = 3e-09
Identities = 41/126 (32%), Positives = 51/126 (40%), Gaps = 24/126 (19%)
Query: 22 YGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCDQ----------CVTSPGCLHGL-C 68
+G C CN NG FC D C+C PGW G C Q C C +G C
Sbjct: 708 WGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADC 767
Query: 69 GE-PGQCICTDGWDGELCDRDVRA------CSS-APCANNGTCVSLDDGLYECSCAPGYS 120
GQC C G+ G C++ + C C NN TC D C C+PG+
Sbjct: 768 DHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTC---DHITGTCYCSPGWK 824
Query: 121 GKDCQK 126
G C +
Sbjct: 825 GARCDQ 830
Score = 34.7 bits (78), Expect = 0.15
Identities = 16/38 (42%), Positives = 18/38 (47%), Gaps = 2/38 (5%)
Query: 21 TYGAECFPACNPQNGFCEDD--NVCRCQPGWQGPLCDQ 56
TYG C C+ N D C C PGW+G CDQ
Sbjct: 793 TYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 115 bits (289), Expect = 5e-26
Identities = 80/269 (29%), Positives = 111/269 (41%), Gaps = 63/269 (23%)
Query: 22 YGAECFPACNPQNG--FCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEP-------- 71
+G C +C+ +NG +D C C PG++GPLC Q + PG C +P
Sbjct: 571 WGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLC-QRICPPGFYGHGCAQPCPLCVHSS 629
Query: 72 -------GQCICTDGWDGELCDRDV------RACSS-APCANNGTCVSLDDGLYECSCAP 117
G C C G+ G LC++ + C+ CANNGTC +D C C P
Sbjct: 630 RPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDG---SCQCFP 686
Query: 118 GYSGKDCQKKD-----GPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC----- 167
G+ GKDC + GP + C +G +C ++G +C C PG++G FC
Sbjct: 687 GWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDG-----ACHCTPGWTGLFCTQRCP 741
Query: 168 -EIVANSC-TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS---------- 215
C C+N C I G +C C GF + C + CA
Sbjct: 742 AAFFGKDCGRVCQCQNGASCDHISG--KCTCRTGFTGQHCEQ---RCAPGTFGYGCQQLC 796
Query: 216 PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
C N TC V+ C C P F G+ C
Sbjct: 797 ECMNNSTC---DHVTGTCYCSPGFKGIRC 822
Score = 113 bits (282), Expect = 3e-25
Identities = 80/274 (29%), Positives = 109/274 (39%), Gaps = 61/274 (22%)
Query: 18 GHSTYGAECFPACNPQ--NGFCEDDNVCRCQPGWQGPLCD----------QCVTSPGCLH 65
G+ G C P C + +G C + C C+PGW GP C C C +
Sbjct: 91 GYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQN 150
Query: 66 GLCGEP--GQCICTDGWDGELCDR------DVRACS-SAPCANNGTCVSLDDGLYECSCA 116
G P G C+C G+ G C+ + C C + +C D EC CA
Sbjct: 151 GALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASC---DPRAGECLCA 207
Query: 117 PGYSGKDCQKKDGP------CVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIV 170
PGY+G C++ P C + PCQ+GGTC G C CPPG++G C
Sbjct: 208 PGYTGVYCEELCPPGSHGAHCELR-CPCQNGGTCHHITG-----ECACPPGWTGAVC--- 258
Query: 171 ANSCTPN----------PCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT------NCAS 214
A C P PC + G C + G +C C AG++ C C+
Sbjct: 259 AQPCPPGTFGQNCSQDCPCHHGGQCDHVTG--QCHCTAGYMGDRCQEECPFGSFGFQCSQ 316
Query: 215 -SPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKK 247
C NGG C T C C+P + G C ++
Sbjct: 317 HCDCHNGGQCSPTTGA---CECEPGYKGPRCQER 347
Score = 112 bits (279), Expect = 7e-25
Identities = 90/268 (33%), Positives = 109/268 (40%), Gaps = 53/268 (19%)
Query: 21 TYGAECFPACNPQNGF-CED-DNVCRCQPGWQGPLCD----------QCVTSPGCLHGLC 68
T+G C +C NG C D C C PGW G C+ C C H
Sbjct: 484 TWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADG 543
Query: 69 GEP--GQCICTDGWDGELCD------RDVRACS-SAPCANNGTCVSLDDGLYECSCAPGY 119
+P G C C GW G CD R CS S C N G+C S +DG C CAPG+
Sbjct: 544 CDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSC-SPEDG--SCECAPGF 600
Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIV------- 170
G CQ+ P Q CV H S C C PGFSG C V
Sbjct: 601 RGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFG 660
Query: 171 ---ANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSR--------PVTNCASSPCQN 219
A C+ C N+G C+ I G C+C G+I K CS+ P A S C N
Sbjct: 661 QDCAQLCS---CANNGTCSPIDGS--CQCFPGWIGKDCSQACPPGFWGPACFHACS-CHN 714
Query: 220 GGTCLQHTQVSYECLCKPEFTGLTCVKK 247
G +C + C C P +TGL C ++
Sbjct: 715 GASC---SAEDGACHCTPGWTGLFCTQR 739
Score = 110 bits (276), Expect = 2e-24
Identities = 84/262 (32%), Positives = 106/262 (40%), Gaps = 46/262 (17%)
Query: 21 TYGAECFPACNPQNG-FCED-DNVCRCQPGWQGPLCDQ----------CVTSPGCLHG-L 67
++GA C C QNG C C C PGW G +C Q C C HG
Sbjct: 223 SHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQ 282
Query: 68 CGE-PGQCICTDGWDGELCDRDVR------ACSS-APCANNGTCVSLDDGLYECSCAPGY 119
C GQC CT G+ G+ C + CS C N G C C C PGY
Sbjct: 283 CDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGA---CECEPGY 339
Query: 120 SGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASH---ASCLCPPGFSGNFCE------IV 170
G CQ++ P ++G C C D + H +C C PG+SG+ C
Sbjct: 340 KGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYY 399
Query: 171 ANSC-TPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVT------NCAS-SPCQNGGT 222
+ C P C+N C I G C C GF+ + C+ NC+S C NGGT
Sbjct: 400 GDGCQLPCTCQNGADCHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGT 457
Query: 223 CLQHTQVSYECLCKPEFTGLTC 244
C + V C CK + GL C
Sbjct: 458 C---SPVDGSCTCKEGWQGLDC 476
Score = 102 bits (254), Expect = 6e-22
Identities = 73/237 (30%), Positives = 95/237 (40%), Gaps = 58/237 (24%)
Query: 44 RCQPGW--QGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRA------CSSA 95
+C PG+ G C T C+HG C P C C GW G C + CS+
Sbjct: 87 QCCPGYYESGDFCIPLCTEE-CVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNR 145
Query: 96 PCANNGTCVSLDDGLYECS-----------CAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
NG + G C+ CAPG GK CQ PC C+HG +C
Sbjct: 146 CQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQL---PC-----QCRHGASC 197
Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPN----------PCENDGVCTDIGGDFRC 194
G CLC PG++G +CE C P PC+N G C I G+ C
Sbjct: 198 DPRAG-----ECLCAPGYTGVYCE---ELCPPGSHGAHCELRCPCQNGGTCHHITGE--C 247
Query: 195 RCPAGFIDKTCSRPV------TNCASS-PCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
CP G+ C++P NC+ PC +GG C V+ +C C + G C
Sbjct: 248 ACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC---DHVTGQCHCTAGYMGDRC 301
Score = 76.6 bits (187), Expect = 3e-14
Identities = 50/173 (28%), Positives = 70/173 (40%), Gaps = 28/173 (16%)
Query: 22 YGAECFPACN-PQNGFCED-DNVCRCQPGWQGPLCDQCVT----SPGCLHGLC------- 68
+G +C C+ NG C D C+C PGW G C Q P C H
Sbjct: 659 FGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASC 718
Query: 69 -GEPGQCICTDGWDGELCDRDVRAC-------SSAPCANNGTCVSLDDGLYECSCAPGYS 120
E G C CT GW G C + A C N +C + +C+C G++
Sbjct: 719 SAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISG---KCTCRTGFT 775
Query: 121 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHAS--CLCPPGFSGNFCEIVA 171
G+ C+++ P G CQ C+++ H + C C PGF G C+ A
Sbjct: 776 GQHCEQRCAPGTF-GYGCQQLCECMNNS-TCDHVTGTCYCSPGFKGIRCDQAA 826
Score = 28.9 bits (63), Expect = 8.1
Identities = 14/38 (36%), Positives = 17/38 (44%), Gaps = 2/38 (5%)
Query: 21 TYGAECFPACNPQNGFCEDD--NVCRCQPGWQGPLCDQ 56
T+G C C N D C C PG++G CDQ
Sbjct: 787 TFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQ 824
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 113 bits (282), Expect = 3e-25
Identities = 60/174 (34%), Positives = 82/174 (47%), Gaps = 10/174 (5%)
Query: 92 CSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRA 151
C+S PC N G C G Y C C+ Y G C+ PC + PC +GGTCV D G
Sbjct: 4017 CASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPC--SSKPCLYGGTCVVDNGGF 4074
Query: 152 SHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
C C ++G C++ + C PC+N G C D C+C +GF + C +
Sbjct: 4075 V---CQCRGLYTGQRCQL-SPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130
Query: 212 CASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLA 265
C+ +PC +G C ++T SY C C E+ G C +P Q P GLA
Sbjct: 4131 CSGNPCLHGALC-ENTHGSYHCNCSHEYRGRHC---EDAAPNQYVSTPWNIGLA 4180
Score = 94.0 bits (232), Expect = 2e-19
Identities = 52/169 (30%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 47 PGWQGPLCDQCVTSPGCLHGLCGEPGQ----CICTDGWDGELCDRDVRACSSAPCANNGT 102
PG + C ++P G+C C C+ + G C+ V CSS PC GT
Sbjct: 4007 PGCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGT 4066
Query: 103 CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGF 162
CV +D+G + C C Y+G+ CQ PC++GGTC D A C C GF
Sbjct: 4067 CV-VDNGGFVCQCRGLYTGQRCQLSP---YCKDEPCKNGGTCFDS---LDGAVCQCDSGF 4119
Query: 163 SGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
G C+ + C+ NPC + +C + G + C C + + C N
Sbjct: 4120 RGERCQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAAPN 4168
Score = 59.3 bits (142), Expect = 6e-09
Identities = 37/122 (30%), Positives = 50/122 (40%), Gaps = 23/122 (18%)
Query: 23 GAECFPACNP-------QNGFCEDDN---VCRCQPGWQGPLCDQCVTSPGCLHGLCGEPG 72
G C + NP G C DN VC+C+ + G +C SP C C G
Sbjct: 4046 GTHCEISVNPCSSKPCLYGGTCVVDNGGFVCQCRGLYTG---QRCQLSPYCKDEPCKNGG 4102
Query: 73 QCI---------CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKD 123
C C G+ GE C D+ CS PC + C + G Y C+C+ Y G+
Sbjct: 4103 TCFDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCEN-THGSYHCNCSHEYRGRH 4161
Query: 124 CQ 125
C+
Sbjct: 4162 CE 4163
Score = 38.5 bits (88), Expect = 0.010
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 211 NCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
+CAS+PCQNGG C Y C C + G C
Sbjct: 4016 DCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHC 4049
Score = 31.2 bits (69), Expect = 1.6
Identities = 18/46 (39%), Positives = 22/46 (47%), Gaps = 6/46 (13%)
Query: 124 CQKKDGPC--VING---SPCQHGGTCVDDEGRASHASCLCPPGFSG 164
C K+G C V +G PC G CV D H +C+CP G G
Sbjct: 3780 CLCKEGRCPPVHHGCEDDPCPEGSECVSDPWEEKH-TCVCPSGRFG 3824
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 110 bits (276), Expect = 2e-24
Identities = 80/247 (32%), Positives = 108/247 (43%), Gaps = 55/247 (22%)
Query: 28 PACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGELCD 86
P C+ + F + C C+PGW+GP C + C L G C + GQCIC DG+ GE C
Sbjct: 159 PFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCID-GQCICDDGFTGEDCS 217
Query: 87 RDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPC-QHGGTCV 145
+ AC S C + G CV +G+ C C GY+G DC ++ P PC + GTCV
Sbjct: 218 Q--LACPS-DCNDQGKCV---NGV--CICFEGYAGADCSREICPV-----PCSEEHGTCV 264
Query: 146 D------------------------DEGRASHASCLCPPGFSGNFCEIVANSCTPNPCEN 181
D + GR C+C GF+G C + PN C +
Sbjct: 265 DGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDC---SELICPNDCFD 321
Query: 182 DGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTG 241
G C I G C C GF + C +P A C G C + +C+C F G
Sbjct: 322 RGRC--ING--TCYCEEGFTGEDCGKPTCPHA---CHTQGRCEEG-----QCVCDEGFAG 369
Query: 242 LTCVKKR 248
+ C +KR
Sbjct: 370 VDCSEKR 376
Score = 97.1 bits (240), Expect = 2e-20
Identities = 75/246 (30%), Positives = 100/246 (40%), Gaps = 63/246 (25%)
Query: 28 PACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCL-HGLCGEPGQCICTDGWDGE--- 83
PA G C D C C G+ G C + GC HG C GQC+C +G+ GE
Sbjct: 378 PADCHNRGRCVDGR-CECDDGFTGADCGELKCPNGCSGHGRCVN-GQCVCDEGYTGEDCS 435
Query: 84 -------------------LCDRDVRA--CSSAPCANN----GTCVSLDDGLYECSCAPG 118
+C++ + CS C N+ G CV+ G+ C C G
Sbjct: 436 QLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVN---GM--CVCDDG 490
Query: 119 YSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNP 178
Y+G+DC+ + P C + G CVD + C+C GF+G C A PN
Sbjct: 491 YTGEDCRDRQCP-----RDCSNRGLCVDGQ-------CVCEDGFTGPDC---AELSCPND 535
Query: 179 CENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPE 238
C G C + +C C GF+ K C C S C G C V +C+C
Sbjct: 536 CHGQGRCVN----GQCVCHEGFMGKDCKEQ--RCPSD-CHGQGRC-----VDGQCICHEG 583
Query: 239 FTGLTC 244
FTGL C
Sbjct: 584 FTGLDC 589
Score = 87.8 bits (216), Expect = 1e-17
Identities = 73/247 (29%), Positives = 96/247 (38%), Gaps = 47/247 (19%)
Query: 23 GAECFPACNPQNGFCED---DNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTD 78
G +C P + F + C C+ G+ G C + C G C E GQC+C +
Sbjct: 307 GEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRC-EEGQCVCDE 365
Query: 79 GWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQK--------KDGP 130
G+ G C + C A C N G CV DG C C G++G DC + G
Sbjct: 366 GFAGVDCSE--KRCP-ADCHNRGRCV---DG--RCECDDGFTGADCGELKCPNGCSGHGR 417
Query: 131 CVINGSPCQHGGT--------CVDD---EGRASHASCLCPPGFSGNFCEIVANSCTPNPC 179
CV C G T C +D GR C+C GF G C + SC PN C
Sbjct: 418 CVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDM--SC-PNDC 474
Query: 180 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEF 239
G C + C C G+ + C C N G C V +C+C+ F
Sbjct: 475 HQHGRCV----NGMCVCDDGYTGEDCR---DRQCPRDCSNRGLC-----VDGQCVCEDGF 522
Query: 240 TGLTCVK 246
TG C +
Sbjct: 523 TGPDCAE 529
Score = 80.5 bits (197), Expect = 2e-15
Identities = 62/190 (32%), Positives = 88/190 (46%), Gaps = 31/190 (16%)
Query: 18 GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLH-GLCGEPGQCIC 76
G+ C C+ Q+G C + +C C G+ G C C + GLC + GQC+C
Sbjct: 462 GYDCSDMSCPNDCH-QHGRCVN-GMCVCDDGYTGEDCRDRQCPRDCSNRGLCVD-GQCVC 518
Query: 77 TDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGS 136
DG+ G C +C + C G CV+ +C C G+ GKDC+++ P S
Sbjct: 519 EDGFTGPDCAE--LSCPN-DCHGQGRCVN-----GQCVCHEGFMGKDCKEQRCP-----S 565
Query: 137 PCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRC 196
C G CVD + C+C GF+G C +SC P+ C N G C + G RC C
Sbjct: 566 DCHGQGRCVDGQ-------CICHEGFTGLDCG--QHSC-PSDCNNLGQC--VSG--RCIC 611
Query: 197 PAGFIDKTCS 206
G+ + CS
Sbjct: 612 NEGYSGEDCS 621
Score = 65.9 bits (159), Expect = 6e-11
Identities = 52/156 (33%), Positives = 72/156 (46%), Gaps = 26/156 (16%)
Query: 18 GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGL--CGEPGQCI 75
G +C C+ G C D C C+ G+ GP C + ++ P HG C GQC+
Sbjct: 493 GEDCRDRQCPRDCS-NRGLCVDGQ-CVCEDGFTGPDCAE-LSCPNDCHGQGRCVN-GQCV 548
Query: 76 CTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVING 135
C +G+ G+ C + C S C G CV DG +C C G++G DC + P
Sbjct: 549 CHEGFMGKDCKE--QRCPS-DCHGQGRCV---DG--QCICHEGFTGLDCGQHSCP----- 595
Query: 136 SPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVA 171
S C + G CV GR C+C G+SG C V+
Sbjct: 596 SDCNNLGQCVS--GR-----CICNEGYSGEDCSEVS 624
>gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
Length = 2699
Score = 109 bits (272), Expect = 5e-24
Identities = 69/229 (30%), Positives = 95/229 (41%), Gaps = 30/229 (13%)
Query: 25 ECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGEL 84
EC C+ NG C C C PG+ GP C + C G+C+C GW G
Sbjct: 517 ECPRNCHG-NGECVS-GTCHCFPGFLGPDCSRAACPVLCSGNGQYSKGRCLCFSGWKGTE 574
Query: 85 CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTC 144
CD C C G C+ + C+C GY G+ C++ D C+ G C + G C
Sbjct: 575 CDVPTTQCIDPQCGGRGICI-----MGSCACNSGYKGESCEEAD--CIDPG--CSNHGVC 625
Query: 145 VDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKT 204
+ H C C PG+ G+ CEI+ C P+ C G G C C +
Sbjct: 626 I-------HGECHCSPGWGGSNCEILKTMC-PDQCSGHGTYLQESGS--CTCDPNWTGPD 675
Query: 205 CSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQ 253
CS + S C + G C+ T C C+ +TG C +RA P+
Sbjct: 676 CSNEI---CSVDCGSHGVCMGGT-----CRCEEGWTGPAC-NQRACHPR 715
Score = 91.3 bits (225), Expect = 1e-18
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 39/201 (19%)
Query: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGC-LHGLCGEPGQCICTDGWDGEL 84
C C+ + ++ C C P W GP C + S C HG+C G C C +GW G
Sbjct: 648 CPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVC-MGGTCRCEEGWTGPA 706
Query: 85 CDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSP--CQHGG 142
C++ RAC CA +GTC DG +C C+ G++G+ C I G P C G
Sbjct: 707 CNQ--RACHPR-CAEHGTC---KDG--KCECSQGWNGEHC-------TIEGCPGLCNSNG 751
Query: 143 TCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFID 202
C D+ + C+C PG+ G C++ + + +N+G G ID
Sbjct: 752 RCTLDQ---NGWHCVCQPGWRGAGCDVAMETLCTDSKDNEG--------------DGLID 794
Query: 203 KTCSRPVTNCASSPCQNGGTC 223
C P C S CQN C
Sbjct: 795 --CMDP-DCCLQSSCQNQPYC 812
Score = 77.4 bits (189), Expect = 2e-14
Identities = 49/167 (29%), Positives = 69/167 (41%), Gaps = 32/167 (19%)
Query: 97 CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASC 156
C NG CVS C C PG+ G DC + P + +G+ G+ S C
Sbjct: 522 CHGNGECVS-----GTCHCFPGFLGPDCSRAACPVLCSGN------------GQYSKGRC 564
Query: 157 LCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSP 216
LC G+ G C++ C C G+C I G C C +G+ ++C +C
Sbjct: 565 LCFSGWKGTECDVPTTQCIDPQCGGRGIC--IMGS--CACNSGYKGESCEE--ADCIDPG 618
Query: 217 CQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYG 263
C N G C+ EC C P + G C + + P Q SG+G
Sbjct: 619 CSNHGVCIHG-----ECHCSPGWGGSNCEILKTMCPDQC----SGHG 656
Score = 76.3 bits (186), Expect = 4e-14
Identities = 45/125 (36%), Positives = 57/125 (45%), Gaps = 23/125 (18%)
Query: 18 GHSTYGAECFPA-CNPQ-------NGFCEDD---------NVCRCQPGWQGPLCDQCVTS 60
GH TY E C+P N C D CRC+ GW GP C+Q
Sbjct: 654 GHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRACH 713
Query: 61 PGCL-HGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGY 119
P C HG C + G+C C+ GW+GE C + C C +NG C +LD + C C PG+
Sbjct: 714 PRCAEHGTC-KDGKCECSQGWNGEHC--TIEGCPGL-CNSNGRC-TLDQNGWHCVCQPGW 768
Query: 120 SGKDC 124
G C
Sbjct: 769 RGAGC 773
Score = 38.9 bits (89), Expect = 0.008
Identities = 30/90 (33%), Positives = 35/90 (38%), Gaps = 22/90 (24%)
Query: 26 CFPACNPQNGFCEDDNV---CRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDG 82
C CN NG C D C CQPGW+G CD + + +CTD D
Sbjct: 743 CPGLCN-SNGRCTLDQNGWHCVCQPGWRGAGCDVAM--------------ETLCTDSKDN 787
Query: 83 E---LCD-RDVRACSSAPCANNGTCVSLDD 108
E L D D C + C N C L D
Sbjct: 788 EGDGLIDCMDPDCCLQSSCQNQPYCRGLPD 817
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.467
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,803,524
Number of Sequences: 37866
Number of extensions: 1071901
Number of successful extensions: 8465
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 218
Number of HSP's that attempted gapping in prelim test: 2378
Number of HSP's gapped (non-prelim): 2208
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.