Search of human proteins with 13775600

Search of human proteins with 13775600

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13775600 sirtuin 2 isoform 1 [Homo sapiens]
         (389 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13775600 sirtuin 2 isoform 1 [Homo sapiens]                        792   0.0  
gi|13775602 sirtuin 2 isoform 2 [Homo sapiens]                        718   0.0  
gi|6912660 sirtuin 3 isoform a [Homo sapiens]                         288   4e-78
gi|63054862 sirtuin 3 isoform b [Homo sapiens]                        270   1e-72
gi|7657575 sirtuin 1 isoform a [Homo sapiens]                         207   1e-53
gi|215982798 sirtuin 1 isoform b [Homo sapiens]                       167   2e-41
gi|6912662 sirtuin 4 [Homo sapiens]                                    73   4e-13
gi|7706710 sirtuin 6 [Homo sapiens]                                    72   7e-13
gi|13787215 sirtuin 5 isoform 2 [Homo sapiens]                         68   2e-11
gi|6912664 sirtuin 5 isoform 1 [Homo sapiens]                          67   2e-11
gi|7706712 sirtuin 7 [Homo sapiens]                                    62   9e-10
gi|55741849 WD repeat domain 22 [Homo sapiens]                         34   0.20 
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ...    32   1.3  
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s...    32   1.3  
gi|239748752 PREDICTED: hypothetical protein XP_002346787 [Homo ...    30   3.7  
gi|124028529 symplekin [Homo sapiens]                                  30   3.7  
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...    30   4.9  
gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]           30   4.9  
gi|93141029 paralemmin isoform 2 [Homo sapiens]                        30   4.9  
gi|93141031 paralemmin isoform 1 [Homo sapiens]                        30   4.9  
gi|22219477 tigger transposable element derived 4 [Homo sapiens]       30   4.9  
gi|130502140 NEZHA isoform 2 [Homo sapiens]                            29   6.3  
gi|122937255 NEZHA isoform 1 [Homo sapiens]                            29   6.3  
gi|157785645 SPEG complex locus [Homo sapiens]                         29   6.3  
gi|82546879 GTP binding protein 1 [Homo sapiens]                       29   8.3  
gi|148231468 GDNF family receptor alpha like [Homo sapiens]            29   8.3  

>gi|13775600 sirtuin 2 isoform 1 [Homo sapiens]
          Length = 389

 Score =  792 bits (2045), Expect = 0.0
 Identities = 389/389 (100%), Positives = 389/389 (100%)

Query: 1   MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD 60
           MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
Sbjct: 1   MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD 60

Query: 61  ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE 120
           ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
Sbjct: 61  ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE 120

Query: 121 ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 180
           ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
Sbjct: 121 ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 180

Query: 181 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 240
           EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
Sbjct: 181 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 240

Query: 241 ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI 300
           ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
Sbjct: 241 ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI 300

Query: 301 MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV 360
           MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
Sbjct: 301 MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV 360

Query: 361 PNPSTSASPKKSPPPAKDEARTTEREKPQ 389
           PNPSTSASPKKSPPPAKDEARTTEREKPQ
Sbjct: 361 PNPSTSASPKKSPPPAKDEARTTEREKPQ 389


>gi|13775602 sirtuin 2 isoform 2 [Homo sapiens]
          Length = 352

 Score =  718 bits (1853), Expect = 0.0
 Identities = 352/352 (100%), Positives = 352/352 (100%)

Query: 38  MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFR 97
           MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFR
Sbjct: 1   MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFR 60

Query: 98  SPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKD 157
           SPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKD
Sbjct: 61  SPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKD 120

Query: 158 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEV 217
           KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEV
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEV 180

Query: 218 TPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAP 277
           TPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAP
Sbjct: 181 TPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAP 240

Query: 278 LSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGW 337
           LSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGW
Sbjct: 241 LSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGW 300

Query: 338 KKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ 389
           KKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
Sbjct: 301 KKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ 352


>gi|6912660 sirtuin 3 isoform a [Homo sapiens]
          Length = 399

 Score =  288 bits (738), Expect = 4e-78
 Identities = 162/356 (45%), Positives = 219/356 (61%), Gaps = 29/356 (8%)

Query: 5   DPSHPLET-------QAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKER 57
           DP+ PL+        +A + Q    + S       GG   + F     S   S GS  + 
Sbjct: 62  DPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK- 120

Query: 58  LLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEA 117
              +L+L+ VA  +++  C+RV+ +VGAGIST +GIPDFRSP +GLY NL++Y LPYPEA
Sbjct: 121 --GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEA 178

Query: 118 IFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAG 177
           IFE+ +F  +P+PFF LAKELYPG +KP + HYF+RLL DKGLLLR YTQNID LER++G
Sbjct: 179 IFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSG 238

Query: 178 LEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGE 237
           +    LVEAHGTF ++ C    C+  +P   ++  + ++  P+C  C  +VKPDIVFFGE
Sbjct: 239 IPASKLVEAHGTFASATC--TVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGE 296

Query: 238 SLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFL 297
            LP RF   +  DF   DLLL++GTSL+V+PFASL      S PRLLIN++         
Sbjct: 297 PLPQRFLLHV-VDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRD--------- 346

Query: 298 GMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASID 353
                L G + +  +   RDVA LG+   G  +L ELLGW +E+ DLV+RE   +D
Sbjct: 347 -----LVGPLAWHPRS--RDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLD 395


>gi|63054862 sirtuin 3 isoform b [Homo sapiens]
          Length = 257

 Score =  270 bits (691), Expect = 1e-72
 Identities = 141/272 (51%), Positives = 183/272 (67%), Gaps = 19/272 (6%)

Query: 82  LVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPG 141
           +VGAGIST +GIPDFRSP +GLY NL++Y LPYPEAIFE+ +F  +P+PFF LAKELYPG
Sbjct: 1   MVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPG 60

Query: 142 QFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCR 201
            +KP + HYF+RLL DKGLLLR YTQNID LER++G+    LVEAHGTF ++ C    C+
Sbjct: 61  NYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATC--TVCQ 118

Query: 202 HEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMG 261
             +P   ++  + ++  P+C  C  +VKPDIVFFGE LP RF   +  DF   DLLL++G
Sbjct: 119 RPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHV-VDFPMADLLLILG 177

Query: 262 TSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWL 321
           TSL+V+PFASL      S PRLLIN++              L G + +  +   RDVA L
Sbjct: 178 TSLEVEPFASLTEAVRSSVPRLLINRD--------------LVGPLAWHPRS--RDVAQL 221

Query: 322 GECDQGCLALAELLGWKKELEDLVRREHASID 353
           G+   G  +L ELLGW +E+ DLV+RE   +D
Sbjct: 222 GDVVHGVESLVELLGWTEEMRDLVQRETGKLD 253


>gi|7657575 sirtuin 1 isoform a [Homo sapiens]
          Length = 747

 Score =  207 bits (527), Expect = 1e-53
 Identities = 111/261 (42%), Positives = 171/261 (65%), Gaps = 14/261 (5%)

Query: 35  EADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIP 94
           E D   L  +    LS   ++++  D  T+E   + +Q   C+++I L GAG+S S GIP
Sbjct: 214 ELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQE--CKKIIVLTGAGVSVSCGIP 271

Query: 95  DFRSPSTGLYDNL--EKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFM 152
           DFRS   G+Y  L  +   LP P+A+F+I YF+K P PFF  AKE+YPGQF+P++CH F+
Sbjct: 272 DFRSRD-GIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFI 330

Query: 153 RLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEK 212
            L   +G LLR YTQNIDTLE++AG+++  +++ HG+F T+ C+   C+++     ++  
Sbjct: 331 ALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGSFATASCL--ICKYKVDCEAVRGD 386

Query: 213 IFSEVTPKCEDCQ-----SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQ 267
           IF++V P+C  C      +++KP+IVFFGE+LP +F   M+ D  +VDLL+V+G+SL+V+
Sbjct: 387 IFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVR 446

Query: 268 PFASLISKAPLSTPRLLINKE 288
           P A + S  P   P++LIN+E
Sbjct: 447 PVALIPSSIPHEVPQILINRE 467


>gi|215982798 sirtuin 1 isoform b [Homo sapiens]
          Length = 452

 Score =  167 bits (422), Expect = 2e-41
 Identities = 80/176 (45%), Positives = 125/176 (71%), Gaps = 9/176 (5%)

Query: 118 IFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAG 177
           +F+I YF+K P PFF  AKE+YPGQF+P++CH F+ L   +G LLR YTQNIDTLE++AG
Sbjct: 1   MFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAG 60

Query: 178 LEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQ-----SLVKPDI 232
           +++  +++ HG+F T+ C+   C+++     ++  IF++V P+C  C      +++KP+I
Sbjct: 61  IQR--IIQCHGSFATASCL--ICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEI 116

Query: 233 VFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKE 288
           VFFGE+LP +F   M+ D  +VDLL+V+G+SL+V+P A + S  P   P++LIN+E
Sbjct: 117 VFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINRE 172


>gi|6912662 sirtuin 4 [Homo sapiens]
          Length = 314

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 57/217 (26%), Positives = 94/217 (43%), Gaps = 33/217 (15%)

Query: 77  RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAK 136
           +R++ + GAGIST +GIPD+RS   GLY   ++  + + + +      +++    F    
Sbjct: 55  KRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWP 114

Query: 137 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 196
           +      +P   H+ +   +  G L    TQN+D L   AG  +  L E HG      C+
Sbjct: 115 QF--SSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LTELHGCMDRVLCL 170

Query: 197 SASCRHEYPL------------SW---------------MKEKIFSEVTPKCEDCQSLVK 229
              C  + P             +W                +E++ S   P C  C   +K
Sbjct: 171 --DCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLK 228

Query: 230 PDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQV 266
           PD+VFFG+++       +     + D LLV+G+SLQV
Sbjct: 229 PDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQV 265


>gi|7706710 sirtuin 6 [Homo sapiens]
          Length = 355

 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 59/213 (27%), Positives = 95/213 (44%), Gaps = 37/213 (17%)

Query: 79  VICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKEL 138
           V+   GAGIST++GIPDFR P  G++   E+   P  +  FE +                
Sbjct: 47  VVFHTGAGISTASGIPDFRGPH-GVWTMEERGLAPKFDTTFESA---------------- 89

Query: 139 YPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSA 198
                +PT  H  +  L+  GLL    +QN+D L   +G  ++ L E HG  +   C  A
Sbjct: 90  -----RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC--A 142

Query: 199 SCRHEYPLSWMKEKIFSEVTPK---------CEDCQSLVKPDIVFFGESLPARFFSCMQS 249
            C+ +Y    +   +  + T +            C+  ++  I+ + +SLP R  +    
Sbjct: 143 KCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADE 202

Query: 250 DFLKVDLLLVMGTSLQVQPFASLISKAPLSTPR 282
                DL + +GTSLQ++P  +L    PL+T R
Sbjct: 203 ASRNADLSITLGTSLQIRPSGNL----PLATKR 231


>gi|13787215 sirtuin 5 isoform 2 [Homo sapiens]
          Length = 299

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 66/251 (26%), Positives = 107/251 (42%), Gaps = 35/251 (13%)

Query: 75  RCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPE---PF 131
           + + ++ + GAG+S  +G+P FR    G +   +   L  P A      F  +P     F
Sbjct: 49  KAKHIVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLA------FAHNPSRVWEF 101

Query: 132 FALAKELYPGQFKPTICHYFMR----LLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAH 187
           +   +E+  G  +P   H  +      L  +G  +   TQNID L R AG +  +L+E H
Sbjct: 102 YHYRREVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTK--NLLEIH 158

Query: 188 GTFYTSHCVSASC---RHEYPL------------SWMKEKIFSEVTPKCED--CQSLVKP 230
           G+ + + C S       ++ P+                  I  E  P+CE+  C  L++P
Sbjct: 159 GSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRP 218

Query: 231 DIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISK-APLSTPRLLINKEK 289
            +V+FGE+L       +  +    DL LV+GTS  V P A    + A    P    N E 
Sbjct: 219 HVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTET 278

Query: 290 AGQSDPFLGMI 300
              ++ F  +I
Sbjct: 279 TPATNRFSHLI 289


>gi|6912664 sirtuin 5 isoform 1 [Homo sapiens]
          Length = 310

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 60/220 (27%), Positives = 97/220 (44%), Gaps = 34/220 (15%)

Query: 75  RCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPE---PF 131
           + + ++ + GAG+S  +G+P FR    G +   +   L  P A      F  +P     F
Sbjct: 49  KAKHIVIISGAGVSAESGVPTFRGAG-GYWRKWQAQDLATPLA------FAHNPSRVWEF 101

Query: 132 FALAKELYPGQFKPTICHYFMR----LLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAH 187
           +   +E+  G  +P   H  +      L  +G  +   TQNID L R AG +  +L+E H
Sbjct: 102 YHYRREVM-GSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTK--NLLEIH 158

Query: 188 GTFYTSHCVSASC---RHEYPL------------SWMKEKIFSEVTPKCED--CQSLVKP 230
           G+ + + C S       ++ P+                  I  E  P+CE+  C  L++P
Sbjct: 159 GSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRP 218

Query: 231 DIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFA 270
            +V+FGE+L       +  +    DL LV+GTS  V P A
Sbjct: 219 HVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAA 258


>gi|7706712 sirtuin 7 [Homo sapiens]
          Length = 400

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 65/252 (25%), Positives = 106/252 (42%), Gaps = 51/252 (20%)

Query: 54  QKERLLDELTLEGVARYMQS--ERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYH 111
           Q+E   D   L G  R + S     + ++   GAGIST+A IPD+R P+ G++  L+K  
Sbjct: 75  QEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPN-GVWTLLQKGR 133

Query: 112 LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDT 171
                 + E                       +PT+ H  +  L ++ L+    +QN D 
Sbjct: 134 SVSAADLSEA----------------------EPTLTHMSITRLHEQKLVQHVVSQNCDG 171

Query: 172 LERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPK----------- 220
           L   +GL +  + E HG  Y   C S     EY       ++F +VT +           
Sbjct: 172 LHLRSGLPRTAISELHGNMYIEVCTSCVPNREY------VRVF-DVTERTALHRHQTGRT 224

Query: 221 CEDCQSLVKPDIVFFGE----SLPARFFSCMQSDFLKVDLLLVMGTSLQV---QPFASLI 273
           C  C + ++  IV FGE      P  + +  ++   + D +L +G+SL+V    P    +
Sbjct: 225 CHKCGTQLRDTIVHFGERGTLGQPLNWEAATEA-ASRADTILCLGSSLKVLKKYPRLWCM 283

Query: 274 SKAPLSTPRLLI 285
           +K P   P+L I
Sbjct: 284 TKPPSRRPKLYI 295


>gi|55741849 WD repeat domain 22 [Homo sapiens]
          Length = 942

 Score = 34.3 bits (77), Expect = 0.20
 Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 11/94 (11%)

Query: 294 DPFLGMIMGLGGGM--DFDSKKAYRDVAWLGECDQGCLALAELLGWKKEL-----EDLVR 346
           + ++ +++  G G+  D+ ++    D   +   D   L   E+ GW  +      E  + 
Sbjct: 387 EEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDS--LVRREIEGWSSDSDSDLSESTIL 444

Query: 347 REHASIDAQSGAGVPNPSTSASPKKSPPPAKDEA 380
           + HA +  +SG    +  +SAS  +SPPP  DE+
Sbjct: 445 QLHAGVSERSG--YTDSESSASLPRSPPPTVDES 476


>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
           sapiens]
          Length = 706

 Score = 31.6 bits (70), Expect = 1.3
 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 7/73 (9%)

Query: 316 RDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPP 375
           R    +G    G LAL+  L  + +L   V+ + A ++A+       PS SASP  SPP 
Sbjct: 155 RPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASP--SPPE 212

Query: 376 AKDEARTTEREKP 388
           +       E E+P
Sbjct: 213 S-----LVEEERP 220


>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
           sapiens]
          Length = 743

 Score = 31.6 bits (70), Expect = 1.3
 Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 7/73 (9%)

Query: 316 RDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPP 375
           R    +G    G LAL+  L  + +L   V+ + A ++A+       PS SASP  SPP 
Sbjct: 141 RPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASP--SPPE 198

Query: 376 AKDEARTTEREKP 388
           +       E E+P
Sbjct: 199 S-----LVEEERP 206


>gi|239748752 PREDICTED: hypothetical protein XP_002346787 [Homo
           sapiens]
          Length = 278

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 12/29 (41%), Positives = 15/29 (51%)

Query: 361 PNPSTSASPKKSPPPAKDEARTTEREKPQ 389
           P P    SPK+SPPP    A +    +PQ
Sbjct: 82  PEPGAGPSPKRSPPPRAPRASSLAAPEPQ 110


>gi|124028529 symplekin [Homo sapiens]
          Length = 1274

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 21/61 (34%), Positives = 33/61 (54%), Gaps = 4/61 (6%)

Query: 329  LALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKP 388
            L LA+    K++LE+  + +   + A S +  P+PS SA P   PPP+ +EA     E P
Sbjct: 1141 LRLAQEKALKRQLEEEQKLKPGGVGAPSSSS-PSPSPSARP--GPPPS-EEAMDFREEGP 1196

Query: 389  Q 389
            +
Sbjct: 1197 E 1197


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 13/37 (35%), Positives = 18/37 (48%)

Query: 352 IDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKP 388
           +DA+ G G P  S  A+P   PPP    A   ++  P
Sbjct: 1   MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPP 37


>gi|118498359 ribosomal L1 domain containing 1 [Homo sapiens]
          Length = 490

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 16/54 (29%), Positives = 24/54 (44%)

Query: 335 LGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKP 388
           +G K    + V  +  +   +S A  PNPST    K+   PA +  +  E E P
Sbjct: 371 IGKKTPANEKVEIQKHATGKKSPAKSPNPSTPRGKKRKALPASETPKAAESETP 424


>gi|93141029 paralemmin isoform 2 [Homo sapiens]
          Length = 343

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 4/45 (8%)

Query: 338 KKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEART 382
           +KE+E L R + A   A+  A  P+P  + +P     PAK+E +T
Sbjct: 92  EKEIEVLERGDSAPATAKENAAAPSPVRAPAPS----PAKEERKT 132


>gi|93141031 paralemmin isoform 1 [Homo sapiens]
          Length = 387

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 4/45 (8%)

Query: 338 KKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEART 382
           +KE+E L R + A   A+  A  P+P  + +P     PAK+E +T
Sbjct: 92  EKEIEVLERGDSAPATAKENAAAPSPVRAPAPS----PAKEERKT 132


>gi|22219477 tigger transposable element derived 4 [Homo sapiens]
          Length = 512

 Score = 29.6 bits (65), Expect = 4.9
 Identities = 41/163 (25%), Positives = 64/163 (39%), Gaps = 32/163 (19%)

Query: 90  SAGIPDFRSPSTGLYDNLEKYHLP--YPEAIFEIS----YFKKHPEPFFALAKELYPGQF 143
           + G+P    PST  Y N+  Y+L   +P+ +F I      ++  P   FA         F
Sbjct: 151 ATGVPV--DPSTVWYQNVLPYYLNDYHPKNVFNIKETGLLYRMLPTNTFA---------F 199

Query: 144 KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSAS---- 199
           K   C    +L KD+  L+     N+D  E++  L         G   T HC        
Sbjct: 200 KGETCSVG-KLCKDRITLV--VGTNMDGSEKLPLL-------VIGKKRTPHCFKGLKSLP 249

Query: 200 -CRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPA 241
            C     ++WM   +F +   K ++     +  +V F ES PA
Sbjct: 250 VCYEANRMAWMTSDVFEQWMRKLDEEFQAQQRRVVIFVESFPA 292


>gi|130502140 NEZHA isoform 2 [Homo sapiens]
          Length = 1249

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 17/38 (44%), Positives = 21/38 (55%)

Query: 339 KELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPA 376
           +E+E   RRE A+  AQ  A  P P  SA P  +P PA
Sbjct: 924 QEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPA 961


>gi|122937255 NEZHA isoform 1 [Homo sapiens]
          Length = 1276

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 17/38 (44%), Positives = 21/38 (55%)

Query: 339 KELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPA 376
           +E+E   RRE A+  AQ  A  P P  SA P  +P PA
Sbjct: 951 QEVEKEQRREEAARLAQEEAPGPAPLVSAVPMATPAPA 988


>gi|157785645 SPEG complex locus [Homo sapiens]
          Length = 3267

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 14/43 (32%), Positives = 24/43 (55%)

Query: 347  REHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ 389
            +E  S+ A S A   +P+  ++PK S P + + + TT  + PQ
Sbjct: 2162 QESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQ 2204


>gi|82546879 GTP binding protein 1 [Homo sapiens]
          Length = 669

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 25/90 (27%), Positives = 35/90 (38%), Gaps = 11/90 (12%)

Query: 1   MAEPDPSHP----LETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKE 56
           M  P+PS P        A ++    DSD   +G A  GE ++D      +  L L S   
Sbjct: 18  MFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELD-----LTSKLVLVSPTS 72

Query: 57  RLLDELTLEGVARYMQSERCRRVICLVGAG 86
              D L  +   R    E C   I ++G G
Sbjct: 73  EQYDSLLRQMWER--MDEGCGETIYVIGQG 100


>gi|148231468 GDNF family receptor alpha like [Homo sapiens]
          Length = 394

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 10/68 (14%)

Query: 200 CRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLV 259
           CR  Y     + K +  VT KC + ++ +         +L  +  +C  SD  K   + +
Sbjct: 233 CRRHYRT--FQSKCWQRVTRKCHEDENCIS--------TLSKQDLTCSGSDDCKAAYIDI 282

Query: 260 MGTSLQVQ 267
           +GT LQVQ
Sbjct: 283 LGTVLQVQ 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,750,464
Number of Sequences: 37866
Number of extensions: 809446
Number of successful extensions: 3468
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 3423
Number of HSP's gapped (non-prelim): 36
length of query: 389
length of database: 18,247,518
effective HSP length: 104
effective length of query: 285
effective length of database: 14,309,454
effective search space: 4078194390
effective search space used: 4078194390
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.