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Search of human proteins with 6912590
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912590 pleckstrin homology-like domain, family A, member 3
[Homo sapiens]
(127 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912590 pleckstrin homology-like domain, family A, member 3 [... 254 1e-68
gi|83977459 pleckstrin homology-like domain, family A, member 1 ... 112 1e-25
gi|4507705 pleckstrin homology-like domain family A member 2 [Ho... 111 2e-25
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 31 0.22
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 31 0.29
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 31 0.29
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 31 0.29
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 31 0.29
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 31 0.29
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 31 0.29
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 31 0.29
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 30 0.38
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 30 0.38
gi|33457316 pleckstrin homology domain containing, family O memb... 30 0.50
gi|239756837 PREDICTED: similar to pleckstrin homology domain co... 29 1.1
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 28 1.5
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 28 1.5
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 28 1.5
gi|40538728 pleckstrin homology domain containing, family M (wit... 28 1.9
gi|154354979 myosin X [Homo sapiens] 28 2.5
gi|46094081 development and differentiation enhancing factor 1 [... 28 2.5
gi|239751418 PREDICTED: hypothetical protein XP_002347841 [Homo ... 27 3.2
gi|98961138 ZXD family zinc finger C isoform 2 [Homo sapiens] 27 3.2
gi|98961133 ZXD family zinc finger C isoform 1 [Homo sapiens] 27 3.2
gi|13384594 protein kinase C, gamma [Homo sapiens] 27 4.2
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 27 4.2
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 27 4.2
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 27 4.2
gi|66348045 zinc finger, C3HC type 1 [Homo sapiens] 27 5.5
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 27 5.5
>gi|6912590 pleckstrin homology-like domain, family A, member 3
[Homo sapiens]
Length = 127
Score = 254 bits (650), Expect = 1e-68
Identities = 127/127 (100%), Positives = 127/127 (100%)
Query: 1 MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKA 60
MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKA
Sbjct: 1 MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKA 60
Query: 61 VECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSL 120
VECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSL
Sbjct: 61 VECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSL 120
Query: 121 GTGTLVS 127
GTGTLVS
Sbjct: 121 GTGTLVS 127
>gi|83977459 pleckstrin homology-like domain, family A, member 1
[Homo sapiens]
Length = 401
Score = 112 bits (279), Expect = 1e-25
Identities = 66/154 (42%), Positives = 86/154 (55%), Gaps = 39/154 (25%)
Query: 1 MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAK---------------- 44
M ++ LKEGVLEKRS GLLQLWK+K C+LTE GL L K
Sbjct: 142 MLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQ 201
Query: 45 ----GTGG------------------RPKELSFARIKAVECVESTGRHIYFTLVTEGGGE 82
G G + KEL F+ +K V+CVE G+++YFT+V G E
Sbjct: 202 QQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKE 261
Query: 83 IDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRA 116
IDFRCP +D GWNA+ITL +V++KN+QAI V++
Sbjct: 262 IDFRCP-QDQGWNAEITLQMVQYKNRQAILAVKS 294
>gi|4507705 pleckstrin homology-like domain family A member 2 [Homo
sapiens]
Length = 152
Score = 111 bits (277), Expect = 2e-25
Identities = 61/110 (55%), Positives = 74/110 (67%), Gaps = 2/110 (1%)
Query: 9 VLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTG 68
VL+EG LEKRS L QLWK+KR VLT L LF A RPKEL F I V+CVE TG
Sbjct: 7 VLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRA-RPKELRFHSILKVDCVERTG 65
Query: 69 RHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQ 118
+++YFT+VT EIDFRC E WNA I L L+ F+N++A+Q R+RQ
Sbjct: 66 KYVYFTIVTTDHKEIDFRCAGES-CWNAAIALALIDFQNRRALQDFRSRQ 114
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 31.2 bits (69), Expect = 0.22
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 281 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGM 312
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 281 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 312
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 281 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 312
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 281 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 312
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 258 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 289
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 120 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 151
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 258 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 289
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 30.8 bits (68), Expect = 0.29
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 7 ATVLKEGVLEKRSGGLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L+ WK+K L G+
Sbjct: 258 AIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGV 289
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 30.4 bits (67), Expect = 0.38
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 11 KEGVLEKRSGGLLQLWKRKRCVLTERGLQLFE 42
+EG L K GG ++ WKR+ +LT+ L FE
Sbjct: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFE 293
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 30.4 bits (67), Expect = 0.38
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 11 KEGVLEKRSGGLLQLWKRKRCVLTERGLQLFE 42
+EG L K GG ++ WKR+ +LT+ L FE
Sbjct: 263 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFE 294
>gi|33457316 pleckstrin homology domain containing, family O member
2 [Homo sapiens]
Length = 490
Score = 30.0 bits (66), Expect = 0.50
Identities = 24/104 (23%), Positives = 47/104 (45%), Gaps = 6/104 (5%)
Query: 11 KEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVES--TG 68
K G ++K SGGLL WK + +L + L ++E + + + + + + +
Sbjct: 21 KAGWIKKSSGGLLGFWKDRYLLLCQAQLLVYENEDDQKCVETVELGSYEKCQDLRALLKR 80
Query: 69 RHIYFTLVTEGG--GEIDFRCPL--EDPGWNAQITLGLVKFKNQ 108
+H + L + G +I F+ P E W + G+ + KN+
Sbjct: 81 KHRFILLRSPGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNK 124
>gi|239756837 PREDICTED: similar to pleckstrin homology domain
containing, family M (with RUN domain) member 1, partial
[Homo sapiens]
Length = 623
Score = 28.9 bits (63), Expect = 1.1
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 13/110 (11%)
Query: 9 VLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTG 68
++K G +E+R G + +WK C L+ +L+ + + S R ++V S G
Sbjct: 101 LMKLGTVERR--GAMGIWKELFCELSPLEFRLYLSNEEHTCVENCSLLRCESVGPAHSDG 158
Query: 69 RHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQ 118
R F LV G ++ R +D A+ L LV+ +A+Q VR +Q
Sbjct: 159 R---FELVF-SGKKLALRASSQD---EAEDWLDLVR----EALQKVRPQQ 197
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 28.5 bits (62), Expect = 1.5
Identities = 15/33 (45%), Positives = 21/33 (63%), Gaps = 1/33 (3%)
Query: 7 ATVLKEGVLEKRSG-GLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L + WK+K L + GL
Sbjct: 402 AIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGL 434
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 28.5 bits (62), Expect = 1.5
Identities = 15/57 (26%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 11 KEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVEST 67
+ G L K+S G+ ++W++++C + L + + GT RP A++ + C T
Sbjct: 308 RNGSLYKKSDGIRKVWQKRKCSVKNGFLTI--SHGTANRPP----AKLNLLTCQVKT 358
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 28.5 bits (62), Expect = 1.5
Identities = 15/57 (26%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 11 KEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVEST 67
+ G L K+S G+ ++W++++C + L + + GT RP A++ + C T
Sbjct: 308 RNGSLYKKSDGIRKVWQKRKCSVKNGFLTI--SHGTANRPP----AKLNLLTCQVKT 358
>gi|40538728 pleckstrin homology domain containing, family M (with
RUN domain) member 1 [Homo sapiens]
Length = 1056
Score = 28.1 bits (61), Expect = 1.9
Identities = 28/111 (25%), Positives = 49/111 (44%), Gaps = 8/111 (7%)
Query: 9 VLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTG 68
++K G +E+R G + +WK C L+ +L+ + + S R ++V S G
Sbjct: 535 LMKLGTVERR--GAMGIWKELFCELSPLEFRLYLSNEEHTCVENCSLLRCESVGPAHSDG 592
Query: 69 RHIYFTLVTEGGGEIDFRCPLEDPG--WNAQITLGLVKFKNQQAIQTVRAR 117
R F LV G ++ R +D W ++ L K + QQ + V +
Sbjct: 593 R---FELVF-SGKKLALRASSQDEAEDWLDRVREALQKVRPQQEDEWVNVQ 639
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 27.7 bits (60), Expect = 2.5
Identities = 11/25 (44%), Positives = 15/25 (60%)
Query: 20 GGLLQLWKRKRCVLTERGLQLFEAK 44
GGL+ WKR+ CVL + F +K
Sbjct: 1186 GGLMNSWKRRWCVLKDETFLWFRSK 1210
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 27.7 bits (60), Expect = 2.5
Identities = 9/21 (42%), Positives = 17/21 (80%)
Query: 11 KEGVLEKRSGGLLQLWKRKRC 31
K+G L K+S G+ ++W+R++C
Sbjct: 327 KKGYLLKKSDGIRKVWQRRKC 347
>gi|239751418 PREDICTED: hypothetical protein XP_002347841 [Homo
sapiens]
Length = 528
Score = 27.3 bits (59), Expect = 3.2
Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 13/110 (11%)
Query: 9 VLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTG 68
++K G +E++ G + +WK C L+ +L+ + + S R ++V S G
Sbjct: 18 LMKLGTVERQ--GAMGIWKELFCELSPLEFRLYLSNEEHTCVENCSLLRCESVGPAHSDG 75
Query: 69 RHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQ 118
R F LV G ++ R +D A+ L LV+ +A+Q VR +Q
Sbjct: 76 R---FELVF-SGKKLALRASSQD---EAEDWLDLVR----EALQKVRPQQ 114
>gi|98961138 ZXD family zinc finger C isoform 2 [Homo sapiens]
Length = 710
Score = 27.3 bits (59), Expect = 3.2
Identities = 12/22 (54%), Positives = 15/22 (68%), Gaps = 2/22 (9%)
Query: 75 LVTEGGGE--IDFRCPLEDPGW 94
L+T GGG+ F+CPLE GW
Sbjct: 196 LLTHGGGQGRRPFKCPLEGCGW 217
>gi|98961133 ZXD family zinc finger C isoform 1 [Homo sapiens]
Length = 858
Score = 27.3 bits (59), Expect = 3.2
Identities = 12/22 (54%), Positives = 15/22 (68%), Gaps = 2/22 (9%)
Query: 75 LVTEGGGE--IDFRCPLEDPGW 94
L+T GGG+ F+CPLE GW
Sbjct: 196 LLTHGGGQGRRPFKCPLEGCGW 217
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 26.9 bits (58), Expect = 4.2
Identities = 22/88 (25%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 31 CVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRC--- 87
C L E+ + +G GGRP L+ + T +YF + GG++ +
Sbjct: 395 CTLVEKRVLALGGRGPGGRPHFLT-----QLHSTFQTPDRLYFVMEYVTGGDLMYHIQQL 449
Query: 88 -PLEDPG---WNAQITLGLVKFKNQQAI 111
++P + A+I +GL NQ I
Sbjct: 450 GKFKEPHAAFYAAEIAIGLFFLHNQGII 477
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 26.9 bits (58), Expect = 4.2
Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 7/32 (21%)
Query: 76 VTEGGGEIDFR-------CPLEDPGWNAQITL 100
VTE GE++ R CPL D W A++ L
Sbjct: 305 VTENHGEVEIRRHLNCSHCPLRDCQWQAELQL 336
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 26.9 bits (58), Expect = 4.2
Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 7/32 (21%)
Query: 76 VTEGGGEIDFR-------CPLEDPGWNAQITL 100
VTE GE++ R CPL D W A++ L
Sbjct: 366 VTENHGEVEIRRHLNCSHCPLRDCQWQAELQL 397
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 26.9 bits (58), Expect = 4.2
Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 7/32 (21%)
Query: 76 VTEGGGEIDFR-------CPLEDPGWNAQITL 100
VTE GE++ R CPL D W A++ L
Sbjct: 305 VTENHGEVEIRRHLNCSHCPLRDCQWQAELQL 336
>gi|66348045 zinc finger, C3HC type 1 [Homo sapiens]
Length = 502
Score = 26.6 bits (57), Expect = 5.5
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 79 GGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQT 113
GG E D P E PGW A +T+ L ++ Q +T
Sbjct: 444 GGTEPDASAPAE-PGWKAVLTILLAHKQSSQPAET 477
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 26.6 bits (57), Expect = 5.5
Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 1/33 (3%)
Query: 7 ATVLKEGVLEKRSG-GLLQLWKRKRCVLTERGL 38
A +K+G+L KRSG L + WK+K L + G+
Sbjct: 345 AIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGV 377
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,683,985
Number of Sequences: 37866
Number of extensions: 196802
Number of successful extensions: 338
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 315
Number of HSP's gapped (non-prelim): 41
length of query: 127
length of database: 18,247,518
effective HSP length: 90
effective length of query: 37
effective length of database: 14,839,578
effective search space: 549064386
effective search space used: 549064386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.