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Search of human proteins with 67782324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|67782324 transforming growth factor, beta receptor II
isoform B precursor [Homo sapiens]
(567 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|67782324 transforming growth factor, beta receptor II isoform... 1174 0.0
gi|67782326 transforming growth factor, beta receptor II isoform... 1159 0.0
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 285 8e-77
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 279 6e-75
gi|4759226 transforming growth factor, beta receptor I isoform 1... 234 1e-61
gi|195963412 transforming growth factor, beta receptor I isoform... 233 3e-61
gi|15451916 bone morphogenetic protein receptor type II precurso... 230 2e-60
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 227 2e-59
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 227 3e-59
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 223 5e-58
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 223 5e-58
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 216 6e-56
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 211 1e-54
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 211 1e-54
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 210 2e-54
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 207 2e-53
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 205 1e-52
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 205 1e-52
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 182 5e-46
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 177 2e-44
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 171 1e-42
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 77 6e-14
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 77 6e-14
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 77 6e-14
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 77 6e-14
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 77 6e-14
gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens] 77 6e-14
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 77 6e-14
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 77 6e-14
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 76 7e-14
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 1174 bits (3036), Expect = 0.0
Identities = 567/567 (100%), Positives = 567/567 (100%)
Query: 1 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST 60
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST
Sbjct: 1 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFST 60
Query: 61 CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK 120
CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK
Sbjct: 61 CDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPK 120
Query: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI 180
CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
Sbjct: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI 180
Query: 181 SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE 240
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE
Sbjct: 181 SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTE 240
Query: 241 LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK 300
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK
Sbjct: 241 LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLK 300
Query: 301 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH 360
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
Sbjct: 301 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH 360
Query: 361 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 420
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
Sbjct: 361 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 420
Query: 421 TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE 480
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
Sbjct: 421 TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE 480
Query: 481 HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE 540
HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE
Sbjct: 481 HPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSE 540
Query: 541 LEHLDRLSGRSCSEEKIPEDGSLNTTK 567
LEHLDRLSGRSCSEEKIPEDGSLNTTK
Sbjct: 541 LEHLDRLSGRSCSEEKIPEDGSLNTTK 567
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 1159 bits (2999), Expect = 0.0
Identities = 566/592 (95%), Positives = 567/592 (95%), Gaps = 25/592 (4%)
Query: 1 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKS-------------------------VNND 35
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKS +NND
Sbjct: 1 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINND 60
Query: 36 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI 95
MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI
Sbjct: 61 MIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENI 120
Query: 96 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT 155
TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
Sbjct: 121 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT 180
Query: 156 SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH 215
SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH
Sbjct: 181 SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH 240
Query: 216 CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA 275
CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA
Sbjct: 241 CAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVA 300
Query: 276 VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE 335
VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
Sbjct: 301 VKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE 360
Query: 336 YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL 395
YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL
Sbjct: 361 YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCL 420
Query: 396 CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW 455
CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW
Sbjct: 421 CDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLW 480
Query: 456 EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE 515
EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE
Sbjct: 481 EMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCE 540
Query: 516 TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK 567
TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Sbjct: 541 TLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK 592
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 285 bits (729), Expect = 8e-77
Identities = 164/430 (38%), Positives = 241/430 (56%), Gaps = 41/430 (9%)
Query: 125 EKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGVA 179
EKK E +F C C + CN+ + E + P V + + SL+P + +A
Sbjct: 93 EKKDSPEVYFCC-CEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIA 151
Query: 180 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNT 239
VI F+ YR ++ T +D S
Sbjct: 152 GIVICAFWVYRHHKMAYPPVLVPT-----------------QDPGPPPPSPLLG------ 188
Query: 240 ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL 299
L P++L + +GRF V+KA+L E VAVKIFP ++ SW+ E +++S +
Sbjct: 189 -LKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPGM 241
Query: 300 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIA 359
KHENILQF+ AE+R T + WLITAFH KG+L ++L +V+SW +L + ++ARG+A
Sbjct: 242 KHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA 301
Query: 360 HLHSDHTPCGRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 418
+LH D P I HRD+KS N+L+KN+LT C+ DFGL+L+ + S D GQ
Sbjct: 302 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQ 359
Query: 419 VGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSK 477
VGT RYMAPEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF +
Sbjct: 360 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEE 418
Query: 478 VREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER 537
+ +HP +E M++ V+ + RP + +W H G+ M+CET+ ECWDHD EARL+A CV ER
Sbjct: 419 IGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER 478
Query: 538 FSELEHLDRL 547
++++ L +
Sbjct: 479 ITQMQRLTNI 488
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 279 bits (713), Expect = 6e-75
Identities = 175/475 (36%), Positives = 253/475 (53%), Gaps = 56/475 (11%)
Query: 77 CEKPQEV---CVAVWRKNDENITL-ETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGET 132
CE Q+ C A WR + I L + C DF D +C+ E+
Sbjct: 49 CEGEQDKRLHCYASWRNSSGTIELVKKGCW-----LDDFNCYDRQ--ECVATEENPQ--- 98
Query: 133 FFMCSCSSDECNDNIIF-----SEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 187
+ C C + CN+ E P + V SLLP G+++ V++ F+
Sbjct: 99 VYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFW 158
Query: 188 CYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
YR +R+ I ED S L P++L
Sbjct: 159 MYR-HRKPPYGHV-----------------DIHEDPGPPPPSPLVG-------LKPLQLL 193
Query: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
+ +GRF V+KA+L + VAVKIFP ++ SW++E++IFS +KHEN+LQF
Sbjct: 194 EIKARGRFGCVWKAQLMN------DFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
Query: 308 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTP 367
+ AE+R + L + WLITAFH KG+L +YL ++I+W +L + +++RG+++LH D
Sbjct: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
Query: 368 C-GRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM 425
C G P I HRD KS N+L+K+DLT L DFGL++R +P D GQVGT RYM
Sbjct: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
Query: 426 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCV 484
APEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF ++ +HP +
Sbjct: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
Query: 485 ESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS 539
E +++ V+ + RP I WL H G+ +C T+ ECWDHD EARL+A CV ER S
Sbjct: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 234 bits (598), Expect = 1e-61
Identities = 144/416 (34%), Positives = 222/416 (53%), Gaps = 13/416 (3%)
Query: 128 KPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 187
K G C+ D CN I S+P L V ++ + P V IS++++ Y
Sbjct: 91 KTGSVTTTYCCNQDHCNK--IELPTTVKSSPGLGPV--ELAAVIAGPVCFVCISLMLMVY 146
Query: 188 -CY-RVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE 245
C+ R ++ + + R + ++ D + S + + T I
Sbjct: 147 ICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIV 206
Query: 246 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL 305
L +GKGRF EV++ K + E VAVKIF E SW E +I+ + L+HENIL
Sbjct: 207 LQESIGKGRFGEVWRGKWRG------EEVAVKIFSSREERSWFREAEIYQTVMLRHENIL 260
Query: 306 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH 365
F+ A+ + Q WL++ +H G+L +YL R+ ++ E + KL S A G+AHLH +
Sbjct: 261 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEI 320
Query: 366 TPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM 425
+ K I HRDLKS NILVK + TCC+ D GL++R D D+A + +VGT RYM
Sbjct: 321 VGT-QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 379
Query: 426 APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVE 485
APEVL+ +N+++ ESFK+ D+Y+M LV WE+ RC+ G +DY+ P+ V P VE
Sbjct: 380 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 439
Query: 486 SMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
M+ V + RP IP+ W + + ++++ + + ECW + ARLTA + + S+L
Sbjct: 440 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 233 bits (595), Expect = 3e-61
Identities = 122/298 (40%), Positives = 180/298 (60%), Gaps = 7/298 (2%)
Query: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
I L +GKGRF EV++ K + E VAVKIF E SW E +I+ + L+HEN
Sbjct: 128 IVLQESIGKGRFGEVWRGKWRG------EEVAVKIFSSREERSWFREAEIYQTVMLRHEN 181
Query: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
IL F+ A+ + Q WL++ +H G+L +YL R+ ++ E + KL S A G+AHLH
Sbjct: 182 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM 241
Query: 364 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 423
+ + K I HRDLKS NILVK + TCC+ D GL++R D D+A + +VGT R
Sbjct: 242 EIVGT-QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 300
Query: 424 YMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPC 483
YMAPEVL+ +N+++ ESFK+ D+Y+M LV WE+ RC+ G +DY+ P+ V P
Sbjct: 301 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 360
Query: 484 VESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
VE M+ V + RP IP+ W + + ++++ + + ECW + ARLTA + + S+L
Sbjct: 361 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 418
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 230 bits (587), Expect = 2e-60
Identities = 167/521 (32%), Positives = 261/521 (50%), Gaps = 76/521 (14%)
Query: 49 QLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLE-----TVCHD 103
+LC F D +S +S+ + T +C K C +W K+ +I L + D
Sbjct: 32 RLCAFKDPYQQDLGIGESRISHENGTILCSKGS-TCYGLWEKSKGDINLVKQGCWSHIGD 90
Query: 104 PKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLL-- 161
P+ +++ + P T+ C CS+D CN N F+E + + L
Sbjct: 91 PQECHYEECVVTTTPPSI-------QNGTYRFCCCSTDLCNVN--FTENFPPPDTTPLSP 141
Query: 162 --------LVIFQVTGISLLPPLGVAISVIIIFYCYRV---NRQQKLSSTWETGKTRKLM 210
+I + +S+L A+ ++ + + YR+ +R+Q L
Sbjct: 142 PHSFNRDETIIIALASVSVL-----AVLIVALCFGYRMLTGDRKQGL------------- 183
Query: 211 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ 270
H ++E S+ S N ++L L+G+GR+ VYK L +
Sbjct: 184 ----HSMNMMEAAASEPSLDLDN----------LKLLELIGRGRYGAVYKGSLDERP--- 226
Query: 271 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGK-QYWLITAFHA 329
VAVK+F + ++ EK+I+ ++H+NI +F+ +ER T G+ +Y L+ ++
Sbjct: 227 ---VAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYP 283
Query: 330 KGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN 389
G+L +YL+ H W +L S+ RG+A+LH++ K I HRDL S N+LVKN
Sbjct: 284 NGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKN 343
Query: 390 DLTCCLCDFGLSLRLDPTLSV----DDLANSGQVGTARYMAPEVLESRMNLENVES-FKQ 444
D TC + DFGLS+RL V +D A +VGT RYMAPEVLE +NL + ES KQ
Sbjct: 344 DGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQ 403
Query: 445 TDVYSMALVLWEMTSRCNAV--GE-VKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIP 501
D+Y++ L+ WE+ RC + GE V +Y+ F ++V HP E M+ V R++ RP+ P
Sbjct: 404 VDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFP 463
Query: 502 SFWL-NHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
W N ++ + ET+ +CWD D EARLTAQC ER +EL
Sbjct: 464 EAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 227 bits (579), Expect = 2e-59
Identities = 145/496 (29%), Positives = 247/496 (49%), Gaps = 43/496 (8%)
Query: 50 LCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYH 109
+C CD TC + +C ++ +T+ E+ + CV++ + + CH
Sbjct: 29 VCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSL-----PELNAQVFCHSSN---- 79
Query: 110 DFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTG 169
+ +C C +D CN+ + + + P L + +
Sbjct: 80 -----NVTKTEC----------------CFTDFCNNITLHLPTASPNAPKLGPMELAI-- 116
Query: 170 ISLLPPLGVAISVIIIFYCYRVN----RQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS 225
I +P ++I+ ++ + + R++K + E L+ + ++ D +
Sbjct: 117 IITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTA 176
Query: 226 DISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA 285
S + + T I L +VGKGRF EV+ + E VAVKIF +
Sbjct: 177 SGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDER 230
Query: 286 SWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWE 345
SW E +I+ + L+HENIL F+ A+ + Q WL++ +H +G+L +YL R++++
Sbjct: 231 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVA 290
Query: 346 DLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLD 405
+ KL S+A G+AHLH + + K I HRD+KS NILVK TC + D GL+++ D
Sbjct: 291 GMIKLALSIASGLAHLHMEIVGT-QGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHD 349
Query: 406 PTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVG 465
L+ D+ + +VGT RYMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+ G
Sbjct: 350 SILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGG 409
Query: 466 EVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDP 525
V++Y+ P+ V P +E M+ V + RP IP+ W + + ++++ + ECW +
Sbjct: 410 IVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANG 469
Query: 526 EARLTAQCVAERFSEL 541
ARLTA + + S+L
Sbjct: 470 AARLTALRIKKTISQL 485
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 227 bits (578), Expect = 3e-59
Identities = 143/444 (32%), Positives = 234/444 (52%), Gaps = 38/444 (8%)
Query: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT-------------SNPDLLLVIFQV 167
CI K + P F C S D N + +++ N +P + + ++
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPV-EL 127
Query: 168 TGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS-- 225
GI P + + +II+F +N Q++ + R ME C + L D++
Sbjct: 128 VGIIAGPVFLLFLIIIIVFLV--INYHQRVYHN----RQRLDME-DPSCEMCLSKDKTLQ 180
Query: 226 ----DISSTCANN----INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK 277
D+S++ + + T I L ++GKGRF EV++ + + VAVK
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD------VAVK 234
Query: 278 IFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 337
IF E SW E +I+ + L+HENIL F+ A+ + Q WL++ +H G+L +YL
Sbjct: 235 IFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 294
Query: 338 TRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCD 397
R+ ++ E + KL S A G+AHLH + + K I HRDLKS NILVK + C + D
Sbjct: 295 NRYTVTIEGMIKLALSAASGLAHLHMEIVGT-QGKPGIAHRDLKSKNILVKKNGMCAIAD 353
Query: 398 FGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEM 457
GL++R D D+A + +VGT RYMAPEVL+ +N+++ +SFK D+Y++ LV WE+
Sbjct: 354 LGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEI 413
Query: 458 TSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETL 517
RCN+ G ++Y+ P+ V P +E M+ V + RP IP++W +++ ++++ + +
Sbjct: 414 ARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMM 473
Query: 518 TECWDHDPEARLTAQCVAERFSEL 541
ECW + ARLTA + + S+L
Sbjct: 474 RECWYANGAARLTALRIKKTLSQL 497
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 223 bits (567), Expect = 5e-58
Identities = 116/298 (38%), Positives = 178/298 (59%), Gaps = 7/298 (2%)
Query: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
I L +VGKGRF EV+ + E VAVKIF + SW E +I+ + L+HEN
Sbjct: 115 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 168
Query: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
IL F+ A+ + Q WL++ +H +G+L +YL R++++ + KL S+A G+AHLH
Sbjct: 169 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 228
Query: 364 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 423
+ + K I HRD+KS NILVK TC + D GL+++ D L+ D+ + +VGT R
Sbjct: 229 EIVGT-QGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKR 287
Query: 424 YMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPC 483
YMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+ G V++Y+ P+ V P
Sbjct: 288 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPS 347
Query: 484 VESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
+E M+ V + RP IP+ W + + ++++ + ECW + ARLTA + + S+L
Sbjct: 348 IEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 405
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 223 bits (567), Expect = 5e-58
Identities = 116/298 (38%), Positives = 178/298 (59%), Gaps = 7/298 (2%)
Query: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
I L +VGKGRF EV+ + E VAVKIF + SW E +I+ + L+HEN
Sbjct: 145 IVLQEIVGKGRFGEVWHGRWCG------EDVAVKIFSSRDERSWFREAEIYQTVMLRHEN 198
Query: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
IL F+ A+ + Q WL++ +H +G+L +YL R++++ + KL S+A G+AHLH
Sbjct: 199 ILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHM 258
Query: 364 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 423
+ + K I HRD+KS NILVK TC + D GL+++ D L+ D+ + +VGT R
Sbjct: 259 EIVGT-QGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKR 317
Query: 424 YMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPC 483
YMAPE+L+ MN+ ESFK+ D+YS+ LV WE+ RC+ G V++Y+ P+ V P
Sbjct: 318 YMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPS 377
Query: 484 VESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
+E M+ V + RP IP+ W + + ++++ + ECW + ARLTA + + S+L
Sbjct: 378 IEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 216 bits (549), Expect = 6e-56
Identities = 131/415 (31%), Positives = 219/415 (52%), Gaps = 24/415 (5%)
Query: 136 CSCSSDECNDNI------IFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCY 189
C +ECN ++ + + ++ ++ VT SLL V+II +CY
Sbjct: 95 CCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLL-------LVLIILFCY 147
Query: 190 RVNRQQKLSSTWETG--KTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
++Q+ + G + + E ++E +S S + + T I++
Sbjct: 148 FRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMV 207
Query: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
+GKGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F
Sbjct: 208 KQIGKGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 261
Query: 308 LTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HT 366
+ A+ + T Q +LIT +H G+L +YL + + + KL S G+ HLH++ +
Sbjct: 262 IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFS 321
Query: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMA 426
G+P I HRDLKS NILVK + TCC+ D GL+++ + D+ + +VGT RYM
Sbjct: 322 TQGKPA--IAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 379
Query: 427 PEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVES 486
PEVL+ +N + +S+ D+YS L+LWE+ RC + G V++Y+ P+ V P E
Sbjct: 380 PEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYED 439
Query: 487 MKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
M++ V + RP P+ W + + ++ + + +TECW H+P +RLTA V + +++
Sbjct: 440 MREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 494
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 211 bits (538), Expect = 1e-54
Identities = 116/306 (37%), Positives = 179/306 (58%), Gaps = 10/306 (3%)
Query: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
I L VGKGR+ EV++ S Q E VAVKIF + SW E ++++ + L+HEN
Sbjct: 208 ITLLECVGKGRYGEVWRG------SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN 261
Query: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
IL F+ ++ Q WLIT +H G+L +YL + ++ S+A G+AHLH
Sbjct: 262 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321
Query: 364 D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 422
+ G+P I HRDLKS NILVK + CC+ D GL++ + + D+ N+ +VGT
Sbjct: 322 EIFGTQGKPA--IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 379
Query: 423 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 482
RYMAPEVL+ + ++ +S+K+ D+++ LVLWE+ R + G V+DY+PPF V P
Sbjct: 380 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 439
Query: 483 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELE 542
E M+ V D+ RP IP+ W + + + + + ECW +P ARLTA + + ++++
Sbjct: 440 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 499
Query: 543 H-LDRL 547
+ LD+L
Sbjct: 500 NSLDKL 505
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 211 bits (538), Expect = 1e-54
Identities = 116/306 (37%), Positives = 179/306 (58%), Gaps = 10/306 (3%)
Query: 244 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 303
I L VGKGR+ EV++ S Q E VAVKIF + SW E ++++ + L+HEN
Sbjct: 208 ITLLECVGKGRYGEVWRG------SWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN 261
Query: 304 ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 363
IL F+ ++ Q WLIT +H G+L +YL + ++ S+A G+AHLH
Sbjct: 262 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321
Query: 364 D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 422
+ G+P I HRDLKS NILVK + CC+ D GL++ + + D+ N+ +VGT
Sbjct: 322 EIFGTQGKPA--IAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 379
Query: 423 RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHP 482
RYMAPEVL+ + ++ +S+K+ D+++ LVLWE+ R + G V+DY+PPF V P
Sbjct: 380 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDP 439
Query: 483 CVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELE 542
E M+ V D+ RP IP+ W + + + + + ECW +P ARLTA + + ++++
Sbjct: 440 SFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID 499
Query: 543 H-LDRL 547
+ LD+L
Sbjct: 500 NSLDKL 505
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 210 bits (535), Expect = 2e-54
Identities = 141/471 (29%), Positives = 243/471 (51%), Gaps = 41/471 (8%)
Query: 84 CVAVWRKNDEN-ITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 142
C A+ ++D+ TL + C K DF +D SPK ++ + C ++
Sbjct: 82 CFAIIEEDDQGETTLASGCM--KYEGSDFQCKD--SPKAQLRRTIE--------CCRTNL 129
Query: 143 CNDNIIFSEEYNTSNPDLLLVIF---QVTGISLLPPLGVAISVIIIF--------YCYRV 191
CN + + P +++ F + + LL + V I +IIF YC +
Sbjct: 130 CNQYL------QPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSI 183
Query: 192 NRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVG 251
+ +++ + E + + E +++ +S S + + T I++ VG
Sbjct: 184 SSRRRYNRDLEQDEA--FIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 241
Query: 252 KGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAE 311
KGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F+ A+
Sbjct: 242 KGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAAD 295
Query: 312 ERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HTPCGR 370
+ T Q +LIT +H G+L ++L + L KL S A G+ HLH++ + G+
Sbjct: 296 IKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGK 355
Query: 371 PKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVL 430
P I HRDLKS NIL+K + +CC+ D GL+++ + + D+ + +VGT RYMAPEVL
Sbjct: 356 PA--IAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVL 413
Query: 431 ESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDN 490
+ +N + + + D+YS L++WEM RC G V++Y+ P+ + V P E M++
Sbjct: 414 DESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREV 473
Query: 491 VLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
V R RP + + W + + ++ V + ++ECW H+P +RLTA + + +++
Sbjct: 474 VCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 207 bits (528), Expect = 2e-53
Identities = 133/411 (32%), Positives = 214/411 (52%), Gaps = 38/411 (9%)
Query: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT-------------SNPDLLLVIFQV 167
CI K + P F C S D N + +++ N +P + + ++
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPV-EL 127
Query: 168 TGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS-- 225
GI P + + +II+F +N Q++ + R ME C + L D++
Sbjct: 128 VGIIAGPVFLLFLIIIIVFLV--INYHQRVYHN----RQRLDME-DPSCEMCLSKDKTLQ 180
Query: 226 ----DISSTCANN----INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK 277
D+S++ + + T I L ++GKGRF EV++ + + VAVK
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD------VAVK 234
Query: 278 IFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 337
IF E SW E +I+ + L+HENIL F+ A+ + Q WL++ +H G+L +YL
Sbjct: 235 IFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 294
Query: 338 TRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCD 397
R+ ++ E + KL S A G+AHLH + + K I HRDLKS NILVK + C + D
Sbjct: 295 NRYTVTIEGMIKLALSAASGLAHLHMEIVGT-QGKPGIAHRDLKSKNILVKKNGMCAIAD 353
Query: 398 FGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEM 457
GL++R D D+A + +VGT RYMAPEVL+ +N+++ +SFK D+Y++ LV WE+
Sbjct: 354 LGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEI 413
Query: 458 TSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQ 508
RCN+ G ++Y+ P+ V P +E M+ V + RP IP++W +++
Sbjct: 414 ARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 205 bits (521), Expect = 1e-52
Identities = 138/429 (32%), Positives = 217/429 (50%), Gaps = 27/429 (6%)
Query: 128 KPGETFFMCSCSSDECNDNIIF--------SEEYNTSNPDLLLVIFQVTGISLLPPLGVA 179
+P E C S CN N+ SE+ T L L++ V + L VA
Sbjct: 80 RPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG-QLALILGPVLALLAL----VA 134
Query: 180 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH----CAIILEDDRSDISSTCANNI 235
+ V+ +++ R +Q+ + E G++ +++ SE +L+ D + S + +
Sbjct: 135 LGVLGLWHVRRRQEKQRGLHS-ELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFL 193
Query: 236 NHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 295
T + L VGKGR+ EV++ E+VAVKIF + SW E +I++
Sbjct: 194 VQRTVARQVALVECVGKGRYGEVWRGLWHG------ESVAVKIFSSRDEQSWFRETEIYN 247
Query: 296 DINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLA 355
+ L+H+NIL F+ ++ Q WLIT +H G+L ++L R + +L S A
Sbjct: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
Query: 356 RGIAHLHSD-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 414
G+AHLH + G+P I HRD KS N+LVK++L CC+ D GL++ D+
Sbjct: 308 CGLAHLHVEIFGTQGKPA--IAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
Query: 415 NSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 474
N+ +VGT RYMAPEVL+ ++ + ES+K TD+++ LVLWE+ R G V+DY PPF
Sbjct: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
Query: 475 GSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV 534
V P E MK V D+ P IP+ + + + + ECW +P ARLTA +
Sbjct: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 535 AERFSELEH 543
+ ++ +
Sbjct: 486 KKTLQKISN 494
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 205 bits (521), Expect = 1e-52
Identities = 138/429 (32%), Positives = 217/429 (50%), Gaps = 27/429 (6%)
Query: 128 KPGETFFMCSCSSDECNDNIIF--------SEEYNTSNPDLLLVIFQVTGISLLPPLGVA 179
+P E C S CN N+ SE+ T L L++ V + L VA
Sbjct: 80 RPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDG-QLALILGPVLALLAL----VA 134
Query: 180 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEH----CAIILEDDRSDISSTCANNI 235
+ V+ +++ R +Q+ + E G++ +++ SE +L+ D + S + +
Sbjct: 135 LGVLGLWHVRRRQEKQRGLHS-ELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFL 193
Query: 236 NHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFS 295
T + L VGKGR+ EV++ E+VAVKIF + SW E +I++
Sbjct: 194 VQRTVARQVALVECVGKGRYGEVWRGLWHG------ESVAVKIFSSRDEQSWFRETEIYN 247
Query: 296 DINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLA 355
+ L+H+NIL F+ ++ Q WLIT +H G+L ++L R + +L S A
Sbjct: 248 TVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAA 307
Query: 356 RGIAHLHSD-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 414
G+AHLH + G+P I HRD KS N+LVK++L CC+ D GL++ D+
Sbjct: 308 CGLAHLHVEIFGTQGKPA--IAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIG 365
Query: 415 NSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 474
N+ +VGT RYMAPEVL+ ++ + ES+K TD+++ LVLWE+ R G V+DY PPF
Sbjct: 366 NNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPF 425
Query: 475 GSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV 534
V P E MK V D+ P IP+ + + + + ECW +P ARLTA +
Sbjct: 426 YDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRI 485
Query: 535 AERFSELEH 543
+ ++ +
Sbjct: 486 KKTLQKISN 494
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 182 bits (463), Expect = 5e-46
Identities = 121/368 (32%), Positives = 190/368 (51%), Gaps = 38/368 (10%)
Query: 121 CIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT-------------SNPDLLLVIFQV 167
CI K + P F C S D N + +++ N +P + + ++
Sbjct: 69 CIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPV-EL 127
Query: 168 TGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRS-- 225
GI P + + +II+F +N Q++ + R ME C + L D++
Sbjct: 128 VGIIAGPVFLLFLIIIIVFLV--INYHQRVYHN----RQRLDME-DPSCEMCLSKDKTLQ 180
Query: 226 ----DISSTCANN----INHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVK 277
D+S++ + + T I L ++GKGRF EV++ + + VAVK
Sbjct: 181 DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGD------VAVK 234
Query: 278 IFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 337
IF E SW E +I+ + L+HENIL F+ A+ + Q WL++ +H G+L +YL
Sbjct: 235 IFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 294
Query: 338 TRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCD 397
R+ ++ E + KL S A G+AHLH + + K I HRDLKS NILVK + C + D
Sbjct: 295 NRYTVTIEGMIKLALSAASGLAHLHMEIVGT-QGKPGIAHRDLKSKNILVKKNGMCAIAD 353
Query: 398 FGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEM 457
GL++R D D+A + +VGT RYMAPEVL+ +N+++ +SFK D+Y++ LV WE+
Sbjct: 354 LGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEI 413
Query: 458 TSRCNAVG 465
RCN+ G
Sbjct: 414 ARRCNSGG 421
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 177 bits (449), Expect = 2e-44
Identities = 87/222 (39%), Positives = 138/222 (62%), Gaps = 1/222 (0%)
Query: 320 QYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRD 379
Q WL++ +H +G+L +YL R++++ + KL S+A G+AHLH + + K I HRD
Sbjct: 108 QLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGT-QGKPAIAHRD 166
Query: 380 LKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENV 439
+KS NILVK TC + D GL+++ D L+ D+ + +VGT RYMAPE+L+ MN+
Sbjct: 167 IKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIF 226
Query: 440 ESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPE 499
ESFK+ D+YS+ LV WE+ RC+ G V++Y+ P+ V P +E M+ V + RP
Sbjct: 227 ESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPS 286
Query: 500 IPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
IP+ W + + ++++ + ECW + ARLTA + + S+L
Sbjct: 287 IPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 328
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 171 bits (434), Expect = 1e-42
Identities = 141/496 (28%), Positives = 228/496 (45%), Gaps = 82/496 (16%)
Query: 84 CVAVWRKNDENITLETV-CHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 142
C +W + +E C D P + + D SP+ PG T F CSC +D
Sbjct: 61 CFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDP-SPRA----HPSPGSTLFTCSCGTDF 115
Query: 143 CNDNIIF-----------SEEYNTSNPDLLLVIFQVTGISLLPPL--GVAISVIIIFYCY 189
CN N S+ + + + + + G+ LL L G I ++ Y
Sbjct: 116 CNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNY 175
Query: 190 RVNRQQKLSSTWETGK--TRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELD 247
RV + ++G+ + +L E E C
Sbjct: 176 RVRGEPVPEPRPDSGRDWSVELQELPELC-----------------------------FS 206
Query: 248 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQF 307
++ +G A V+ +L Q + VA+K FP A ++ E+ ++ L+H++I++F
Sbjct: 207 QVIREGGHAVVWAGQL------QGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRF 260
Query: 308 LTAEERKT-ELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHT 366
+TA L L+ H KG+L YLT++ W ++ SLA+G+A LH +
Sbjct: 261 ITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERW 320
Query: 367 PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL---------DPTLSVDDLANSG 417
G+ K I HRDL S N+L++ D +C + D GL+L L PT A
Sbjct: 321 QNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIM- 379
Query: 418 QVGTARYMAPEVLESRMNLEN-VESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPP--- 473
+ GT RYMAPE+L+ ++L++ + ++ D+YS+AL+LWE+ SRC + D PP
Sbjct: 380 EAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLR--PDSSPPPFQ 437
Query: 474 --FGSKVREHPCVESMKDNVLRDRGRPEIPSFW----LNHQGIQMVCETLTECWDHDPEA 527
+ +++ P + + +++R RP IPS W + G++ E L +CWD DPEA
Sbjct: 438 LAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLR---ELLEDCWDADPEA 494
Query: 528 RLTAQCVAERFSELEH 543
RLTA+CV +R + L H
Sbjct: 495 RLTAECVQQRLAALAH 510
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 76.6 bits (187), Expect = 6e-14
Identities = 66/241 (27%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 234 NINHNTELLPIELD-TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKD 292
N+ +N + PI + +G+G F VYK + NT+ + +A + E + +++
Sbjct: 51 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQE 109
Query: 293 IFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT----RHVISWEDLR 348
I +HEN+++ L G L+ + G+L + L+ +SW
Sbjct: 110 IKVMAKCQHENLVELLGFSSD----GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRC 165
Query: 349 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 408
K+ A GI LH +H +HRD+KS+NIL+ T + DFGL+ +
Sbjct: 166 KIAQGAANGINFLHENHH---------IHRDIKSANILLDEAFTAKISDFGLARASEK-- 214
Query: 409 SVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 468
+ S VGT YMAPE L E ++D+YS +VL E+ + AV E +
Sbjct: 215 FAQTVMTSRIVGTTAYMAPEALRG-------EITPKSDIYSFGVVLLEIITGLPAVDEHR 267
Query: 469 D 469
+
Sbjct: 268 E 268
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 76.6 bits (187), Expect = 6e-14
Identities = 66/241 (27%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 234 NINHNTELLPIELD-TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKD 292
N+ +N + PI + +G+G F VYK + NT+ + +A + E + +++
Sbjct: 51 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQE 109
Query: 293 IFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT----RHVISWEDLR 348
I +HEN+++ L G L+ + G+L + L+ +SW
Sbjct: 110 IKVMAKCQHENLVELLGFSSD----GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRC 165
Query: 349 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 408
K+ A GI LH +H +HRD+KS+NIL+ T + DFGL+ +
Sbjct: 166 KIAQGAANGINFLHENHH---------IHRDIKSANILLDEAFTAKISDFGLARASEK-- 214
Query: 409 SVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 468
+ S VGT YMAPE L E ++D+YS +VL E+ + AV E +
Sbjct: 215 FAQTVMTSRIVGTTAYMAPEALRG-------EITPKSDIYSFGVVLLEIITGLPAVDEHR 267
Query: 469 D 469
+
Sbjct: 268 E 268
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 76.6 bits (187), Expect = 6e-14
Identities = 66/241 (27%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 234 NINHNTELLPIELD-TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKD 292
N+ +N + PI + +G+G F VYK + NT+ + +A + E + +++
Sbjct: 51 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQE 109
Query: 293 IFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT----RHVISWEDLR 348
I +HEN+++ L G L+ + G+L + L+ +SW
Sbjct: 110 IKVMAKCQHENLVELLGFSSD----GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRC 165
Query: 349 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 408
K+ A GI LH +H +HRD+KS+NIL+ T + DFGL+ +
Sbjct: 166 KIAQGAANGINFLHENHH---------IHRDIKSANILLDEAFTAKISDFGLARASEK-- 214
Query: 409 SVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 468
+ S VGT YMAPE L E ++D+YS +VL E+ + AV E +
Sbjct: 215 FAQTVMTSRIVGTTAYMAPEALRG-------EITPKSDIYSFGVVLLEIITGLPAVDEHR 267
Query: 469 D 469
+
Sbjct: 268 E 268
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 76.6 bits (187), Expect = 6e-14
Identities = 66/241 (27%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 234 NINHNTELLPIELD-TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKD 292
N+ +N + PI + +G+G F VYK + NT+ + +A + E + +++
Sbjct: 175 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQE 233
Query: 293 IFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT----RHVISWEDLR 348
I +HEN+++ L G L+ + G+L + L+ +SW
Sbjct: 234 IKVMAKCQHENLVELLGFSSD----GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRC 289
Query: 349 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 408
K+ A GI LH +H +HRD+KS+NIL+ T + DFGL+ +
Sbjct: 290 KIAQGAANGINFLHENHH---------IHRDIKSANILLDEAFTAKISDFGLARASEK-- 338
Query: 409 SVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 468
+ S VGT YMAPE L E ++D+YS +VL E+ + AV E +
Sbjct: 339 FAQTVMTSRIVGTTAYMAPEALRG-------EITPKSDIYSFGVVLLEIITGLPAVDEHR 391
Query: 469 D 469
+
Sbjct: 392 E 392
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 76.6 bits (187), Expect = 6e-14
Identities = 66/241 (27%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 234 NINHNTELLPIELD-TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKD 292
N+ +N + PI + +G+G F VYK + NT+ + +A + E + +++
Sbjct: 175 NVTNNFDERPISVGGNKMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQE 233
Query: 293 IFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT----RHVISWEDLR 348
I +HEN+++ L G L+ + G+L + L+ +SW
Sbjct: 234 IKVMAKCQHENLVELLGFSSD----GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRC 289
Query: 349 KLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTL 408
K+ A GI LH +H +HRD+KS+NIL+ T + DFGL+ +
Sbjct: 290 KIAQGAANGINFLHENHH---------IHRDIKSANILLDEAFTAKISDFGLARASEK-- 338
Query: 409 SVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 468
+ S VGT YMAPE L E ++D+YS +VL E+ + AV E +
Sbjct: 339 FAQTVMTSRIVGTTAYMAPEALRG-------EITPKSDIYSFGVVLLEIITGLPAVDEHR 391
Query: 469 D 469
+
Sbjct: 392 E 392
>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
Length = 387
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/219 (27%), Positives = 110/219 (50%), Gaps = 30/219 (13%)
Query: 249 LVGKGRFAEVYKAKLKQNTSEQFETVAVKI-----FPYEEYASWKT----EKDIFSDINL 299
++G+G + V + + + TS+++ + + F EE + E DI ++
Sbjct: 25 ILGRG-VSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVS- 82
Query: 300 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHV-ISWEDLRKLGSSLARGI 358
H NI+Q E T ++L+ +G L +YLT V +S ++ RK+ +L I
Sbjct: 83 GHPNIIQLKDTYETNTF----FFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVI 138
Query: 359 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 418
LH K+ IVHRDLK NIL+ +++ L DFG S +L+P + ++
Sbjct: 139 CTLH---------KLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVC---- 185
Query: 419 VGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEM 457
GT Y+APE++E MN ++ K+ D++S ++++ +
Sbjct: 186 -GTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTL 223
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 76.6 bits (187), Expect = 6e-14
Identities = 69/243 (28%), Positives = 116/243 (47%), Gaps = 33/243 (13%)
Query: 223 DRSDISSTCANNINH-NTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY 281
+++DI A +H + +L IE ++G G F +VYK + + + VA+K +
Sbjct: 441 EKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN------KIVAIKRYRA 494
Query: 282 EEYASWKTEKDIFSD-----INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEY 336
Y S K++ D+F L H ++QF+ A Q+ ++T + + G+L
Sbjct: 495 NTYCS-KSDVDMFCREVSILCQLNHPCVIQFVGACLNDPS---QFAIVTQYISGGSLFSL 550
Query: 337 L--TRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC 394
L + ++ + + +A+G+ +LH+ PI+HRDL S NIL+ D
Sbjct: 551 LHEQKRILDLQSKLIIAVDVAKGMEYLHN-------LTQPIIHRDLNSHNILLYEDGHAV 603
Query: 395 LCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVL 454
+ DFG S L S+D+ + Q G R+MAPEV + + DV+S AL L
Sbjct: 604 VADFGESRFLQ---SLDEDNMTKQPGNLRWMAPEVF-----TQCTRYTIKADVFSYALCL 655
Query: 455 WEM 457
WE+
Sbjct: 656 WEI 658
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 76.6 bits (187), Expect = 6e-14
Identities = 69/243 (28%), Positives = 116/243 (47%), Gaps = 33/243 (13%)
Query: 223 DRSDISSTCANNINH-NTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPY 281
+++DI A +H + +L IE ++G G F +VYK + + + VA+K +
Sbjct: 542 EKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN------KIVAIKRYRA 595
Query: 282 EEYASWKTEKDIFSD-----INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEY 336
Y S K++ D+F L H ++QF+ A Q+ ++T + + G+L
Sbjct: 596 NTYCS-KSDVDMFCREVSILCQLNHPCVIQFVGACLNDPS---QFAIVTQYISGGSLFSL 651
Query: 337 L--TRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC 394
L + ++ + + +A+G+ +LH+ PI+HRDL S NIL+ D
Sbjct: 652 LHEQKRILDLQSKLIIAVDVAKGMEYLHN-------LTQPIIHRDLNSHNILLYEDGHAV 704
Query: 395 LCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVL 454
+ DFG S L S+D+ + Q G R+MAPEV + + DV+S AL L
Sbjct: 705 VADFGESRFLQ---SLDEDNMTKQPGNLRWMAPEVF-----TQCTRYTIKADVFSYALCL 756
Query: 455 WEM 457
WE+
Sbjct: 757 WEI 759
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 76.3 bits (186), Expect = 7e-14
Identities = 63/219 (28%), Positives = 101/219 (46%), Gaps = 48/219 (21%)
Query: 251 GKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTA 310
G G F VY+AK S+ E K+ E+ E +I S L H NI+QF
Sbjct: 23 GGGSFGSVYRAKW---ISQDKEVAVKKLLKIEK------EAEILSV--LSHRNIIQFYGV 71
Query: 311 EERKTELGKQYWLITAFHAKGNLQEYLTR---------HVISWEDLRKLGSSLARGIAHL 361
G ++T + + G+L +Y+ H+++W + +A+G+ +L
Sbjct: 72 ILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTW------ATDVAKGMHYL 121
Query: 362 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 421
H + + ++HRDLKS N+++ D +CDFG S + T + VGT
Sbjct: 122 HME------APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHT------THMSLVGT 169
Query: 422 ARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSR 460
+MAPEV++S + + D YS +VLWEM +R
Sbjct: 170 FPWMAPEVIQS------LPVSETCDTYSYGVVLWEMLTR 202
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,837,471
Number of Sequences: 37866
Number of extensions: 1012459
Number of successful extensions: 3887
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 307
Number of HSP's successfully gapped in prelim test: 406
Number of HSP's that attempted gapping in prelim test: 2829
Number of HSP's gapped (non-prelim): 830
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.