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Search of human proteins with 6005814
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005814 serine/threonine kinase 38 [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 948 0.0
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 824 0.0
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 383 e-106
gi|4758666 LATS homolog 1 [Homo sapiens] 377 e-104
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 308 5e-84
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 308 5e-84
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 308 5e-84
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 296 3e-80
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 283 2e-76
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 275 6e-74
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 274 1e-73
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 274 1e-73
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 274 1e-73
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 274 1e-73
gi|32698688 citron [Homo sapiens] 248 8e-66
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 225 8e-59
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 221 1e-57
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 219 3e-57
gi|148727255 microtubule associated serine/threonine kinase fami... 219 3e-57
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 219 4e-57
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 219 5e-57
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 219 5e-57
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 219 5e-57
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 218 7e-57
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 211 1e-54
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 209 3e-54
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 209 6e-54
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 207 1e-53
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 207 1e-53
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 207 2e-53
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 948 bits (2451), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60
MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE
Sbjct: 1 MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60
Query: 61 EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL 120
EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL
Sbjct: 61 EKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKIL 120
Query: 121 RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK 180
RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK
Sbjct: 121 RKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK 180
Query: 181 KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA 240
KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA
Sbjct: 181 KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKA 240
Query: 241 HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN 300
HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN
Sbjct: 241 HRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN 300
Query: 301 KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 360
KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF
Sbjct: 301 KLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRF 360
Query: 361 CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK 420
CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK
Sbjct: 361 CCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILK 420
Query: 421 PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK
Sbjct: 421 PTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 824 bits (2128), Expect = 0.0
Identities = 405/466 (86%), Positives = 430/466 (92%), Gaps = 4/466 (0%)
Query: 1 MAMT-GSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKD 59
MAMT G+T MSNHT+ERVT+ K+TLENFYSNLI QHEERE RQKKLE MEEEGL D
Sbjct: 1 MAMTAGTTTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLAD 60
Query: 60 EEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKI 119
EEK+LRRS HARKETEFLRLKRTRLGL+DFESLKVIGRGAFGEVRLVQKKDTGH+YAMKI
Sbjct: 61 EEKKLRRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKI 120
Query: 120 LRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLM 179
LRK+DMLEKEQV HIRAERDILVEAD WVVKMFYSFQDK NLYLIMEFLPGGDMMTLLM
Sbjct: 121 LRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLM 180
Query: 180 KKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKK 239
KKDTLTEEETQFYI+ETVLAID+IHQLGFIHRDIKPDNLLLD+KGHVKLSDFGLCTGLKK
Sbjct: 181 KKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKK 240
Query: 240 AHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGY 299
AHRTEFYRNL H+ PSDF+FQNMNSKRKAETWK+NRRQLA+STVGTPDYIAPEVFMQTGY
Sbjct: 241 AHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGY 300
Query: 300 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILR 359
NKLCDWWSLGVIMYEMLIGYPPFCSETPQETY+KVMNWKETL FPPEVPISEKAKDLILR
Sbjct: 301 NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILR 360
Query: 360 FCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDIL 419
FC + E+RIG GVEEIK + FFEGVDWEHIRERPAAI IEIKSIDDTSNFD+FPESDIL
Sbjct: 361 FCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDIL 420
Query: 420 KPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKAAK 465
+P N E DYK+KDWVF+NYTYKRFEGLT RG+IP+YMKA K
Sbjct: 421 QP---VPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGK 463
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 383 bits (983), Expect = e-106
Identities = 196/443 (44%), Positives = 287/443 (64%), Gaps = 18/443 (4%)
Query: 24 KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
K +E N+I ++++ R+ +LE+ M + GL + E+ R +KE+ + RLKR +
Sbjct: 603 KFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAK 662
Query: 84 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
+ F +K +G GAFGEV L K DT +YAMK LRK D+L + QV H++AERDIL E
Sbjct: 663 MDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 722
Query: 144 ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
AD+ WVVK++YSFQDK +LY +M+++PGGDMM+LL++ + E +FYIAE LAI+S+
Sbjct: 723 ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESV 782
Query: 204 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNH-----SLPSDFT 258
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y+ +H PSD
Sbjct: 783 HKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLW 842
Query: 259 FQNMNSK-------RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
N + + K+++R LA S VGTP+YIAPEV ++ GY +LCDWWS+GVI
Sbjct: 843 DDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVI 902
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
++EML+G PPF + TP ET KV+NW+ TL P +V +S +A+DLI + CC +HR+G
Sbjct: 903 LFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN 962
Query: 372 GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFD----EFPESDILK-PTVAT 425
G +++K++ FF +D+ IR++PA I DTSNFD E P +D + T A
Sbjct: 963 GADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAW 1022
Query: 426 SNHPETDYKNKDWVFINYTYKRF 448
+ K+ + F +T++RF
Sbjct: 1023 DTLTSPNNKHPEHAFYEFTFRRF 1045
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 377 bits (967), Expect = e-104
Identities = 190/444 (42%), Positives = 284/444 (63%), Gaps = 19/444 (4%)
Query: 24 KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
K +E N++ H++R R+K+LE M GL + + R +KE+ ++RLKR +
Sbjct: 640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAK 699
Query: 84 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
+ F +K +G GAFGEV L +K DT +YA K LRK D+L + QV H++AERDIL E
Sbjct: 700 MDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE 759
Query: 144 ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
AD+ WVV+++YSFQDK NLY +M+++PGGDMM+LL++ E +FYIAE A++S+
Sbjct: 760 ADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESV 819
Query: 204 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN-- 261
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y++ +H F N
Sbjct: 820 HKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEW 879
Query: 262 --MNSKRKAETWK--------RNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
+S R + K +++R LA S VGTP+YIAPEV ++TGY +LCDWWS+GVI
Sbjct: 880 GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI 939
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
++EML+G PPF ++TP ET KV+NW+ +L PP+ +S +A DLI++ C E R+G
Sbjct: 940 LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN 999
Query: 372 GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
G +EIK++ FF+ +D+ +R++ A+ +I DTSNFD + N +
Sbjct: 1000 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059
Query: 431 T------DYKNKDWVFINYTYKRF 448
T + K+ + F +T++RF
Sbjct: 1060 TLNGWYKNGKHPEHAFYEFTFRRF 1083
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 308 bits (790), Expect = 5e-84
Identities = 175/412 (42%), Positives = 242/412 (58%), Gaps = 48/412 (11%)
Query: 64 LRRSAHARKETEFLR-----LKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMK 118
LRR + + E+ + +K +L EDFE +KVIGRGAFGEV +V+ K+T +YAMK
Sbjct: 46 LRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMK 105
Query: 119 ILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL 178
IL K +ML++ + R ERD+LV D W+ + Y+FQD+ +LYL+M++ GGD++TLL
Sbjct: 106 ILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL 165
Query: 179 MK-KDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGL 237
K +D L E+ +FYI E VLAIDSIHQL ++HRDIKPDN+LLD GH++L+DFG C
Sbjct: 166 SKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCL-- 223
Query: 238 KKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--M 295
+ D T Q+ VGTPDYI+PE+ M
Sbjct: 224 --------------KMNDDGTVQSS------------------VAVGTPDYISPEILQAM 251
Query: 296 QTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISE 351
+ G Y CDWWSLGV MYEML G PF +E+ ETY K+MN +E FP V +SE
Sbjct: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311
Query: 352 KAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+AKDLI R C E R+G G+E+ K ++FFEG++WE+IR A ++ S DTSNFD
Sbjct: 312 EAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFD 371
Query: 412 EFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEGLTARGAIPSYMKA 463
+ D+L+ T T + FI +T+ + RG++ S M++
Sbjct: 372 --VDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQS 421
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 308 bits (790), Expect = 5e-84
Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)
Query: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
++K+ RL EDFE LKVIGRGAFGEV +V+ K+ V+AMKIL K +ML++ + R E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
RD+LV D+ W+ + Y+FQD NLYL+M++ GGD++TLL K +D L E+ +FY+AE
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
V+AIDS+HQL ++HRDIKPDN+L+D GH++L+DFG C L D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229
Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
T Q+ VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370
MYEML G PF +E+ ETY K+MN KE FP +V +SE AKDLI R C EHR+G
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
G+E+ K + FF G+DW++IR A E+ S DTSNFD + D LK +
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
Query: 431 TDYKNKDWVFINYTY 445
T + F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 308 bits (790), Expect = 5e-84
Identities = 169/375 (45%), Positives = 225/375 (60%), Gaps = 43/375 (11%)
Query: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
++K+ RL EDFE LKVIGRGAFGEV +V+ K+ V+AMKIL K +ML++ + R E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
RD+LV D+ W+ + Y+FQD NLYL+M++ GGD++TLL K +D L E+ +FY+AE
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
V+AIDS+HQL ++HRDIKPDN+L+D GH++L+DFG C L D
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCL----------------KLMED 229
Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
T Q+ VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 230 GTVQSS------------------VAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVC 271
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV-PISEKAKDLILRFCCEWEHRIGA 370
MYEML G PF +E+ ETY K+MN KE FP +V +SE AKDLI R C EHR+G
Sbjct: 272 MYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQ 331
Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
G+E+ K + FF G+DW++IR A E+ S DTSNFD + D LK +
Sbjct: 332 NGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFD--VDDDCLKNSETMPPPTH 389
Query: 431 TDYKNKDWVFINYTY 445
T + F+ +TY
Sbjct: 390 TAFSGHHLPFVGFTY 404
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 296 bits (757), Expect = 3e-80
Identities = 163/382 (42%), Positives = 226/382 (59%), Gaps = 57/382 (14%)
Query: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
++K RL +DFE LKVIGRGAFGEV +V+++DTG ++AMK+L K +ML++ + R E
Sbjct: 60 KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119
Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAET 196
RD+LV+ DS WV + Y+FQD+ LYL+M++ GGD++TLL + +D L E QFY+AE
Sbjct: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
Query: 197 VLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSD 256
VLAI S+HQLG++HRD+KPDN+LLD GH++L+DFG C L N N + S
Sbjct: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRL----------NTNGMVDSS 229
Query: 257 FTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF--MQTG---YNKLCDWWSLGVI 311
VGTPDYI+PE+ M+ G Y CDWWSLGV
Sbjct: 230 V------------------------AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVC 265
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVP-ISEKAKDLILRFCCEWEHRIGA 370
YE+L G PF +E+ ETY K+MN ++ L FPP+VP + A+DLI + C E R+G
Sbjct: 266 AYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGR 325
Query: 371 PGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
G+++ +++ FFEGVDWE + A E++ DTSNFD + T NHP
Sbjct: 326 GGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDD---------TLNHPG 376
Query: 431 T-------DYKNKDWVFINYTY 445
T + F+ +TY
Sbjct: 377 TLPPPSHGAFSGHHLPFVGFTY 398
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 283 bits (725), Expect = 2e-76
Identities = 150/344 (43%), Positives = 211/344 (61%), Gaps = 41/344 (11%)
Query: 78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAE 137
+++ R+ ED+E +KVIGRGAFGEV+LV+ K T VYAMK+L K +M+++ E
Sbjct: 65 KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124
Query: 138 RDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 197
RDI+ A+S WVV++FY+FQD LY++ME++PGGD++ L+ D + E+ +FY AE V
Sbjct: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVV 183
Query: 198 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 257
LA+D+IH +GFIHRD+KPDN+LLD GH+KL+DFG C + K
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVR------------- 230
Query: 258 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMY 313
+ VGTPDYI+PEV G Y + CDWWS+GV +Y
Sbjct: 231 ---------------------CDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 269
Query: 314 EMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGV 373
EML+G PF +++ TY K+MN K +LTFP + IS++AK+LI F + E R+G GV
Sbjct: 270 EMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGV 329
Query: 374 EEIKSNSFFEGVD--WEHIRERPAAISIEIKSIDDTSNFDEFPE 415
EEIK + FF+ WE +R+ A + ++ S DTSNFD+ E
Sbjct: 330 EEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE 373
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 275 bits (703), Expect = 6e-74
Identities = 153/383 (39%), Positives = 223/383 (58%), Gaps = 45/383 (11%)
Query: 71 RKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQ 130
R E +++ ++ ED++ +KVIGRGAFGEV+LV+ K + VYAMK+L K +M+++
Sbjct: 74 RYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSD 133
Query: 131 VGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQ 190
ERDI+ A+S WVV++FY+FQD LY++ME++PGGD++ L+ D + E+ +
Sbjct: 134 SAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAK 192
Query: 191 FYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLN 250
FY AE VLA+D+IH +G IHRD+KPDN+LLD GH+KL+DFG C + +
Sbjct: 193 FYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVH------ 246
Query: 251 HSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG----YNKLCDWW 306
+ VGTPDYI+PEV G Y + CDWW
Sbjct: 247 ----------------------------CDTAVGTPDYISPEVLKSQGGDGFYGRECDWW 278
Query: 307 SLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH 366
S+GV +YEML+G PF +++ TY K+M+ K +L FP + IS+ AK+LI F + E
Sbjct: 279 SVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREV 338
Query: 367 RIGAPGVEEIKSNSFFEGVD--WEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVA 424
R+G GVEEI+ + FF+ W++IRE A + E+ S D+SNFD+ + K V
Sbjct: 339 RLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDD---KGDVE 395
Query: 425 TSNHPETDYKNKDWVFINYTYKR 447
T P+ + FI +TY R
Sbjct: 396 TFPIPKA-FVGNQLPFIGFTYYR 417
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 274 bits (701), Expect = 1e-73
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)
Query: 77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
+RLK RL +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V R
Sbjct: 69 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128
Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY+AE
Sbjct: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188
Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
V+AIDS+H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 232
Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
D T +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 233 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274
Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
GV YEM G PF +++ ETY K++++KE L+ P + + E+A+D I R C E R
Sbjct: 275 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 334
Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+G G + +++ FF G+DW+ +R+ + + + DT NFD
Sbjct: 335 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 378
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 274 bits (701), Expect = 1e-73
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)
Query: 77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
+RLK RL +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
V+AIDS+H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
D T +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
GV YEM G PF +++ ETY K++++KE L+ P + + E+A+D I R C E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+G G + +++ FF G+DW+ +R+ + + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 274 bits (701), Expect = 1e-73
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)
Query: 77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
+RLK RL +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
V+AIDS+H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
D T +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
GV YEM G PF +++ ETY K++++KE L+ P + + E+A+D I R C E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+G G + +++ FF G+DW+ +R+ + + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 274 bits (701), Expect = 1e-73
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)
Query: 77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
+RLK RL +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V R
Sbjct: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
Query: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY+AE
Sbjct: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
V+AIDS+H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
D T +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
Query: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
GV YEM G PF +++ ETY K++++KE L+ P + + E+A+D I R C E R
Sbjct: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
Query: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+G G + +++ FF G+DW+ +R+ + + + DT NFD
Sbjct: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 248 bits (633), Expect = 8e-66
Identities = 139/383 (36%), Positives = 211/383 (55%), Gaps = 46/383 (12%)
Query: 79 LKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAER 138
L+ + +DFE ++G G F EV++V++K TG +YAMK+++K +L +EQV ER
Sbjct: 87 LQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEER 146
Query: 139 DILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAETV 197
+IL + S W+ ++ Y+FQDK +LYL+ME+ PGGD+++LL + +D L E QFY+AE +
Sbjct: 147 NILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELI 206
Query: 198 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 257
LA+ S+H +G++HRDIKP+N+L+D GH+KL DFG A + + +N LP
Sbjct: 207 LAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFG------SAAKMNSNKMVNAKLP--- 257
Query: 258 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM------QTGYNKLCDWWSLGVI 311
+GTPDY+APEV + Y CDWWS+GVI
Sbjct: 258 -------------------------IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVI 292
Query: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
YEM+ G PF T T+ +MN++ L FP + +S DLI C + R+
Sbjct: 293 AYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFE 352
Query: 372 GVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPET 431
G + + FF +DW +IR P +KS DDTSNFDE PE + + P +
Sbjct: 353 G---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDE-PEKNSWVSSSPCQLSP-S 407
Query: 432 DYKNKDWVFINYTYKRFEGLTAR 454
+ ++ F+ ++Y + G+ R
Sbjct: 408 GFSGEELPFVGFSYSKALGILGR 430
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 225 bits (573), Expect = 8e-59
Identities = 141/432 (32%), Positives = 220/432 (50%), Gaps = 63/432 (14%)
Query: 1 MAMTGSTPCSSMSNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDE 60
MA PC+ + T LE F S L +H + +K +E + L
Sbjct: 1 MAAYREPPCNQYTG-----TTTALQKLEGFASRLFHRHSKGTAHDQKT--ALENDSLHFS 53
Query: 61 EK-----RLRRSAHARKETEFLRL----KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDT 111
E R + A+ + +FL+ + GLEDFE K +G G+FG V LV+ K T
Sbjct: 54 EHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKAT 113
Query: 112 GHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPG 171
YAMKIL K +++ +Q+ H E+ IL + ++V++ Y+F+D NLY++ME++PG
Sbjct: 114 EQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPG 173
Query: 172 GDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDF 231
G+M + L + +E +FY A+ VL + +H L I+RD+KP+NLL+D +G+++++DF
Sbjct: 174 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDF 233
Query: 232 GLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAP 291
G + K TW + GTP+Y+AP
Sbjct: 234 GFA-----------------------------KRVKGRTW---------TLCGTPEYLAP 255
Query: 292 EVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISE 351
E+ + GYNK DWW+LGV++YEM GYPPF ++ P + Y+K+++ K + FP S
Sbjct: 256 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSS 311
Query: 352 KAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFEGVDWEHIRER--PAAISIEIKSIDD 406
KDL+ + R G GV +IK++ +F DW I +R A + + D
Sbjct: 312 DLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGD 371
Query: 407 TSNFDEFPESDI 418
TSNFD++ E DI
Sbjct: 372 TSNFDDYEEEDI 383
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 221 bits (563), Expect = 1e-57
Identities = 130/328 (39%), Positives = 192/328 (58%), Gaps = 44/328 (13%)
Query: 89 FESLKVIGRGAFGEVRLVQKK---DTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
FE LKV+G+G+FG+V LV+KK D G +YAMK+L+KA + +++V + ERDILVE +
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVN 131
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE LA+D +HQ
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191
Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
LG ++RD+KP+N+LLD GH+KL+DFGL SK
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGL------------------------------SK 221
Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
+ K+ A+S GT +Y+APEV + G+++ DWWS GV+M+EML G PF +
Sbjct: 222 ESVDQEKK-----AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK 276
Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGV 385
ET ++ K + P+ +E L + F +R+G+ GVEEIK + FF +
Sbjct: 277 DRNETMNMILKAKLGM---PQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANI 333
Query: 386 DWEHIRERPAAISIEIKS--IDDTSNFD 411
DW+ + +R + S DDT FD
Sbjct: 334 DWDKLYKREVQPPFKPASGKPDDTFCFD 361
Score = 101 bits (251), Expect = 2e-21
Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 50/279 (17%)
Query: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
E +E + IG G++ + T +A+KI+ K+ E++ +IL+
Sbjct: 424 EVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI-------EILMRYGQ 476
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
++ + F D +YL+ + + GG+++ ++K+ +E E + +D +H
Sbjct: 477 HPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHC 536
Query: 206 LGFIHRDIKPDNLLL----DSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
G +HRD+KP N+L S +++ DFG L
Sbjct: 537 QGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL------------------------ 572
Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
R L + T +++APEV MQ GY+ CD WSLGV+ Y ML GY P
Sbjct: 573 -----------RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTP 621
Query: 322 FC---SETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
F ++TP+E ++ N K +L+ IS+ AKDL+
Sbjct: 622 FANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL 660
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 219 bits (559), Expect = 3e-57
Identities = 127/365 (34%), Positives = 199/365 (54%), Gaps = 25/365 (6%)
Query: 48 LEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQ 107
LE+++ L++E+ S +R R K DFE++K+I GA+G V LV+
Sbjct: 329 LEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCE---SDFETIKLISNGAYGAVYLVR 385
Query: 108 KKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIME 167
+DT +A+K + K +++ + Q+ + ERDIL A++ +VV MF SF+ + +L ++ME
Sbjct: 386 HRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVME 445
Query: 168 FLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVK 227
++ GGD TLL L + + Y AETVLA++ +H G +HRD+KPDNLL+ S GH+K
Sbjct: 446 YVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIK 505
Query: 228 LSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPD 287
L+DFGL + T Y + K R + GTP+
Sbjct: 506 LTDFGLSKIGLMSMATNLY--------------------EGHIEKDAREFIDKQVCGTPE 545
Query: 288 YIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV 347
YIAPEV + GY K DWW++GV++YE L+G PF +TP+E + +V++ E + +
Sbjct: 546 YIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVS-DEIMWPEGDE 604
Query: 348 PISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDD 406
+ A+DLI R + R+G G E+K + FF +DW + A ++++ DD
Sbjct: 605 ALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDD 664
Query: 407 TSNFD 411
TS FD
Sbjct: 665 TSYFD 669
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 219 bits (559), Expect = 3e-57
Identities = 121/328 (36%), Positives = 184/328 (56%), Gaps = 28/328 (8%)
Query: 88 DFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSL 147
DFE++K+I GA+G V V+ K++ +AMK + K +++ + Q+ ERDIL A++
Sbjct: 380 DFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 439
Query: 148 WVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG 207
+VV M+ SF+ + +L ++ME++ GGD TL+ L + + Y AETVLA++ +H G
Sbjct: 440 FVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYG 499
Query: 208 FIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
+HRD+KPDNLL+ S GH+KL+DFGL + T Y +
Sbjct: 500 IVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLY--------------------E 539
Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 327
K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +TP
Sbjct: 540 GHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTP 599
Query: 328 QETYKKV----MNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFE 383
+E + +V +NW E PP P ++ L+LR R+G G E+K + FF
Sbjct: 600 EELFGQVISDEINWPEKDEAPP--PDAQDLITLLLR--QNPLERLGTGGAYEVKQHRFFR 655
Query: 384 GVDWEHIRERPAAISIEIKSIDDTSNFD 411
+DW + + A +++S DDTS FD
Sbjct: 656 SLDWNSLLRQKAEFIPQLESEDDTSYFD 683
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 219 bits (558), Expect = 4e-57
Identities = 131/384 (34%), Positives = 207/384 (53%), Gaps = 64/384 (16%)
Query: 40 EREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGA 99
E+E ++ L K +E+ LK E + +AH L+ FE +K +G G+
Sbjct: 12 EQESVKEFLAKA-KEDFLKKWESPAQNTAH----------------LDQFERIKTLGTGS 54
Query: 100 FGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDK 159
FG V LV+ K+TG+ YAMKIL K +++ +Q+ H E+ IL + ++VK+ +SF+D
Sbjct: 55 FGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDN 114
Query: 160 LNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLL 219
NLY++ME++PGG+M + L + +E +FY A+ VL + +H L I+RD+KP+NLL
Sbjct: 115 SNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLL 174
Query: 220 LDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA 279
+D +G+++++DFG + K TW
Sbjct: 175 IDQQGYIQVTDFGFA-----------------------------KRVKGRTW-------- 197
Query: 280 FSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKE 339
+ GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPPF ++ P + Y+K+++ K
Sbjct: 198 -TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK- 255
Query: 340 TLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFEGVDWEHIRER--P 394
+ FP S KDL+ + R G GV +IK++ +F DW I +R
Sbjct: 256 -VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVE 312
Query: 395 AAISIEIKSIDDTSNFDEFPESDI 418
A + K DTSNFD++ E +I
Sbjct: 313 APFIPKFKGPGDTSNFDDYEEEEI 336
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 219 bits (557), Expect = 5e-57
Identities = 122/327 (37%), Positives = 185/327 (56%), Gaps = 24/327 (7%)
Query: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 146
EDFE++K+I GA+G V LV+ K T +AMK + K +++ + Q+ ERDIL A++
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 147 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206
+VV MF SF K +L ++ME++ GGD TLL L + + Y AETVLA++ +H
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 629
Query: 207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 266
G +HRD+KPDNLL+ S GH+KL+DFGL + T Y
Sbjct: 630 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLY-------------------- 669
Query: 267 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 326
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF +T
Sbjct: 670 EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDT 729
Query: 327 PQETYKKVMNWKETLTFPP-EVPISEKAKDLILRFCCEWE-HRIGAPGVEEIKSNSFFEG 384
P+E + +V++ + + +P + + A+DL + + R+G E+K + FF G
Sbjct: 730 PEELFGQVIS--DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTG 787
Query: 385 VDWEHIRERPAAISIEIKSIDDTSNFD 411
+DW + + A +++S DDTS FD
Sbjct: 788 LDWTGLLRQKAEFIPQLESEDDTSYFD 814
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 219 bits (557), Expect = 5e-57
Identities = 121/338 (35%), Positives = 190/338 (56%), Gaps = 47/338 (13%)
Query: 86 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
L+ FE +K +G G+FG V LV+ K+TG+ YAMKIL K +++ +Q+ H E+ IL +
Sbjct: 33 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 92
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
++VK+ +SF+D NLY++ME++PGG+M + L + +E +FY A+ VL + +H
Sbjct: 93 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 152
Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
L I+RD+KP+NLL+D +G+++++DFG +
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFA-----------------------------KR 183
Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM GYPPF ++
Sbjct: 184 VKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 234
Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFF 382
P + Y+K+++ K + FP S KDL+ + R G GV +IK++ +F
Sbjct: 235 QPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 290
Query: 383 EGVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
DW I +R A + K DTSNFD++ E +I
Sbjct: 291 ATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 328
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 219 bits (557), Expect = 5e-57
Identities = 125/358 (34%), Positives = 196/358 (54%), Gaps = 51/358 (14%)
Query: 70 ARKETEFLRL----KRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADM 125
A+ + +FL+ + GLEDFE K +G G+FG V LV+ K T YAMKIL K +
Sbjct: 21 AKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKV 80
Query: 126 LEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLT 185
++ +Q+ H E+ IL + ++V++ Y+F+D NLY++ME++PGG+M + L + +
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 186 EEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEF 245
E +FY A+ VL + +H L I+RD+KP+NLL+D +G+++++DFG
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA----------- 189
Query: 246 YRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDW 305
+ K TW + GTP+Y+APE+ + GYNK DW
Sbjct: 190 ------------------KRVKGRTW---------TLCGTPEYLAPEIILSKGYNKAVDW 222
Query: 306 WSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEW 364
W+LGV++YEM GYPPF ++ P + Y+K+++ K + FP S KDL+ +
Sbjct: 223 WALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK--VRFPSH--FSSDLKDLLRNLLQVDL 278
Query: 365 EHRIG--APGVEEIKSNSFFEGVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
R G GV +IK++ +F DW I +R A + + DTSNFD++ E DI
Sbjct: 279 TKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 336
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 218 bits (556), Expect = 7e-57
Identities = 121/329 (36%), Positives = 184/329 (55%), Gaps = 24/329 (7%)
Query: 85 GLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA 144
G DF+++K+I GA+G V LV+ +DT +AMK + K +++ + Q+ ERDIL A
Sbjct: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429
Query: 145 DSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIH 204
++ +VV MF SF+ + +L ++ME++ GGD TLL L E + Y AETVLA++ +H
Sbjct: 430 ENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLH 489
Query: 205 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 264
G +HRD+KPDNLL+ S GH+KL+DFGL + T Y
Sbjct: 490 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLY------------------ 531
Query: 265 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 324
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF
Sbjct: 532 --EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG 589
Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFF 382
+TP+E + +V++ + + +P L++ + R+GA G E+K +SFF
Sbjct: 590 DTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF 647
Query: 383 EGVDWEHIRERPAAISIEIKSIDDTSNFD 411
+DW + + A ++S DDTS FD
Sbjct: 648 RDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 211 bits (537), Expect = 1e-54
Identities = 131/360 (36%), Positives = 200/360 (55%), Gaps = 46/360 (12%)
Query: 39 EEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRG 98
+ E Q+ +++ M EE + + + + S T ++ + FE LKV+G+G
Sbjct: 20 DSAENGQQIMDEPMGEEEINPQTEEV--SIKEIAITHHVKEGHEKADPSQFELLKVLGQG 77
Query: 99 AFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYS 155
+FG+V LV+K D +YAMK+L+KA + +++V + ERDILVE + ++VK+ Y+
Sbjct: 78 SFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYA 136
Query: 156 FQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKP 215
FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE LA+D +H LG I+RD+KP
Sbjct: 137 FQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKP 196
Query: 216 DNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNR 275
+N+LLD +GH+KL+DFGL SK + K+
Sbjct: 197 ENILLDEEGHIKLTDFGL------------------------------SKESIDHEKK-- 224
Query: 276 RQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVM 335
A+S GT +Y+APEV + G+ + DWWS GV+M+EML G PF + +ET ++
Sbjct: 225 ---AYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL 281
Query: 336 NWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFEGVDWEHIRER 393
K + P+ E L + F +R+GA GVEEIK +SFF +DW + R
Sbjct: 282 KAKLGM---PQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRR 338
Score = 97.4 bits (241), Expect = 2e-20
Identities = 68/279 (24%), Positives = 129/279 (46%), Gaps = 50/279 (17%)
Query: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
+ +E + IG G++ + K T +A+KI+ K+ E++ +IL+
Sbjct: 420 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI-------EILLRYGQ 472
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
++ + + D +Y++ E + GG+++ ++++ +E E + ++ +H
Sbjct: 473 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 532
Query: 206 LGFIHRDIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
G +HRD+KP N+L +D G+ +++ DFG L
Sbjct: 533 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL------------------------ 568
Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
R L + T +++APEV + GY+ CD WSLGV++Y ML GY P
Sbjct: 569 -----------RAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTP 617
Query: 322 FCS---ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
F + +TP+E ++ + K +L+ +S+ AKDL+
Sbjct: 618 FANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLV 656
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 209 bits (533), Expect = 3e-54
Identities = 145/411 (35%), Positives = 218/411 (53%), Gaps = 63/411 (15%)
Query: 20 VTMTKVTLENFYSNLIAQHEEREMRQKKLE-KVMEEEGLKDEEKRLRRSAHARKETEFLR 78
++M K + F+S + R+ R K +EEEG+ K + S H ++ E
Sbjct: 3 LSMKKFAVRRFFSVYL----RRKSRSKSSSLSRLEEEGVV---KEIDISHHVKEGFE--- 52
Query: 79 LKRTRLGLEDFESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIR 135
+ FE LKV+G+G++G+V LV+K D G +YAMK+L+KA + +++V +
Sbjct: 53 ----KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRV-RSK 107
Query: 136 AERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAE 195
ERDIL E + ++VK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE
Sbjct: 108 MERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 167
Query: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
LA+D +H LG I+RD+KP+N+LLD +GH+K++DFGL
Sbjct: 168 LALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGL---------------------- 205
Query: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 315
SK + KR A+S GT +Y+APEV + G+ + DWWS GV+M+EM
Sbjct: 206 --------SKEAIDHDKR-----AYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEM 252
Query: 316 LIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGV 373
L G PF + +ET ++ K + P+ E L F +R+GA GV
Sbjct: 253 LTGSLPFQGKDRKETMALILKAKLGM---PQFLSGEAQSLLRALFKRNPCNRLGAGIDGV 309
Query: 374 EEIKSNSFFEGVDWEHI--RERPAAISIEIKSIDDTSNFDEFPESDILKPT 422
EEIK + FF +DW + +E + +DT +FD PE PT
Sbjct: 310 EEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFD--PEFTARTPT 358
Score = 98.6 bits (244), Expect = 1e-20
Identities = 69/279 (24%), Positives = 128/279 (45%), Gaps = 50/279 (17%)
Query: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-AD 145
+ +E + IG G++ + K T YA+KI+ K+ E++ +IL+
Sbjct: 413 DGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEI-------EILLRYGQ 465
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
++ + + D +YL+ME + GG+++ ++++ +E E + +D +H
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
Query: 206 LGFIHRDIKPDNLLL-DSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 261
G +HRD+KP N+L D G +++ DFG L+ +
Sbjct: 526 QGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNG------------------- 566
Query: 262 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 321
L + T +++APEV + GY+ CD WSLG+++Y ML G+ P
Sbjct: 567 ----------------LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTP 610
Query: 322 FCS---ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
F + +TP+E ++ + K L+ IS+ AKD++
Sbjct: 611 FANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVV 649
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 209 bits (531), Expect = 6e-54
Identities = 117/337 (34%), Positives = 187/337 (55%), Gaps = 47/337 (13%)
Query: 87 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 146
+ FE L+ +G G+FG V LV+ ++TG YAMKIL K +++ +QV HI E+ IL D
Sbjct: 42 DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101
Query: 147 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 206
++VK+ +SF+D LYL+ME++PGG+M + L + +E FY A+ VLA+ +H L
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 207 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 266
IHRD+KP+NLL+D +G+++++DFG +
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFA-----------------------------KRV 192
Query: 267 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 326
K TW + GTP+Y+APE+ + GYNK DWW+LGV++YEM +G+PPF ++
Sbjct: 193 KGRTW---------TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQ 243
Query: 327 PQETYKKVMNWKETLTFPPEVPISEKAKDLILRFC-CEWEHRIG--APGVEEIKSNSFFE 383
P + Y+K+++ + + FP + +S K L+ + R G GV +IK++ +F
Sbjct: 244 PIQIYEKIVSGR--VRFPSK--LSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFA 299
Query: 384 GVDWEHIRER--PAAISIEIKSIDDTSNFDEFPESDI 418
W I E+ A + D SNFD++ E ++
Sbjct: 300 TTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEEL 336
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 207 bits (528), Expect = 1e-53
Identities = 126/330 (38%), Positives = 187/330 (56%), Gaps = 46/330 (13%)
Query: 89 FESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
FE LKV+G+G+FG+V LV+K D+GH+YAMK+L+KA + +++V + ERDIL + +
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 129
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
+VVK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE L +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 189
Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
LG I+RD+KP+N+LLD +GH+KL+DFGL SK
Sbjct: 190 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 219
Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
+ K+ A+S GT +Y+APEV + G++ DWWS GV+M+EML G PF +
Sbjct: 220 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 274
Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFE 383
+ET ++ K + P+ +E L F +R+G+ G EEIK + F+
Sbjct: 275 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 331
Query: 384 GVDWEHI--RERPAAISIEIKSIDDTSNFD 411
+DW + RE + DDT FD
Sbjct: 332 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 361
Score = 108 bits (269), Expect = 1e-23
Identities = 72/273 (26%), Positives = 130/273 (47%), Gaps = 50/273 (18%)
Query: 93 KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-ADSLWVVK 151
+ IG G++ E + K T YA+K++ K+ E++ +IL+ ++
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQHPNIIT 483
Query: 152 MFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHR 211
+ + D ++YL+ E + GG+++ ++++ +E E F + ++ +H G +HR
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
Query: 212 DIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
D+KP N+L +D G+ +++ DFG L
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQL------------------------------ 573
Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC---S 324
R L + T +++APEV + GY++ CD WSLG+++Y ML GY PF S
Sbjct: 574 -----RAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS 628
Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
+TP+E ++ + K TL+ +SE AKDL+
Sbjct: 629 DTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 661
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 207 bits (528), Expect = 1e-53
Identities = 126/330 (38%), Positives = 187/330 (56%), Gaps = 46/330 (13%)
Query: 89 FESLKVIGRGAFGEVRLVQK---KDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 145
FE LKV+G+G+FG+V LV+K D+GH+YAMK+L+KA + +++V + ERDIL + +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVN 120
Query: 146 SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQ 205
+VVK+ Y+FQ + LYLI++FL GGD+ T L K+ TEE+ +FY+AE L +D +H
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180
Query: 206 LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSK 265
LG I+RD+KP+N+LLD +GH+KL+DFGL SK
Sbjct: 181 LGIIYRDLKPENILLDEEGHIKLTDFGL------------------------------SK 210
Query: 266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325
+ K+ A+S GT +Y+APEV + G++ DWWS GV+M+EML G PF +
Sbjct: 211 EAIDHEKK-----AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGK 265
Query: 326 TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGA--PGVEEIKSNSFFE 383
+ET ++ K + P+ +E L F +R+G+ G EEIK + F+
Sbjct: 266 DRKETMTLILKAKLGM---PQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 322
Query: 384 GVDWEHI--RERPAAISIEIKSIDDTSNFD 411
+DW + RE + DDT FD
Sbjct: 323 TIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352
Score = 108 bits (269), Expect = 1e-23
Identities = 72/273 (26%), Positives = 130/273 (47%), Gaps = 50/273 (18%)
Query: 93 KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE-ADSLWVVK 151
+ IG G++ E + K T YA+K++ K+ E++ +IL+ ++
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEI-------EILLRYGQHPNIIT 474
Query: 152 MFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHR 211
+ + D ++YL+ E + GG+++ ++++ +E E F + ++ +H G +HR
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
Query: 212 DIKPDNLL-LDSKGH---VKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRK 267
D+KP N+L +D G+ +++ DFG L
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQL------------------------------ 564
Query: 268 AETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFC---S 324
R L + T +++APEV + GY++ CD WSLG+++Y ML GY PF S
Sbjct: 565 -----RAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPS 619
Query: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLI 357
+TP+E ++ + K TL+ +SE AKDL+
Sbjct: 620 DTPEEILTRIGSGKFTLSGGNWNTVSETAKDLV 652
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 207 bits (526), Expect = 2e-53
Identities = 124/368 (33%), Positives = 197/368 (53%), Gaps = 44/368 (11%)
Query: 56 GLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQ-KKDTGHV 114
GL D + A A+ + E L L DF + +G G FG V LVQ K +
Sbjct: 327 GLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKT 386
Query: 115 YAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDM 174
+AMKIL+K +++ Q HIR+E+ I+ A S ++V+++ +F+D LY++ME GG++
Sbjct: 387 FAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGEL 446
Query: 175 MTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLC 234
T+L + + + T+FY A V A +H G I+RD+KP+NL+LD +G+ KL DFG
Sbjct: 447 WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGF- 505
Query: 235 TGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVF 294
A + F + +TW + GTP+Y+APE+
Sbjct: 506 -----AKKIGFGK---------------------KTW---------TFCGTPEYVAPEII 530
Query: 295 MQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAK 354
+ G++ D+WSLG++MYE+L G PPF P +TY ++ + + FP + I++ A
Sbjct: 531 LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKK--IAKNAA 588
Query: 355 DLILRFCCE-WEHRIG--APGVEEIKSNSFFEGVDWEHIRERPAAISI--EIKSIDDTSN 409
+LI + C + R+G GV++I+ + +FEG +WE +R+ I + S DTSN
Sbjct: 589 NLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSN 648
Query: 410 FDEFPESD 417
FD FPE +
Sbjct: 649 FDSFPEDN 656
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,739,226
Number of Sequences: 37866
Number of extensions: 798354
Number of successful extensions: 6180
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 680
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 3439
Number of HSP's gapped (non-prelim): 2046
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.