Search of human proteins with 5803177

Search of human proteins with 5803177

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5803177 basic beta 2 syntrophin [Homo sapiens]
         (540 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5803177 basic beta 2 syntrophin [Homo sapiens]                    1079   0.0  
gi|11321640 basic beta 1 syntrophin [Homo sapiens]                    587   e-167
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                   429   e-120
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                         142   1e-33
gi|9507163 syntrophin, gamma 1 [Homo sapiens]                         125   8e-29
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    85   1e-16
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    85   1e-16
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    74   3e-13
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    69   1e-11
gi|8922944 lin-7 homolog C [Homo sapiens]                              68   2e-11
gi|11545920 lin-7 homolog B [Homo sapiens]                             67   5e-11
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           66   7e-11
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           66   7e-11
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    66   7e-11
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    66   9e-11
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    66   9e-11
gi|4759306 lin-7 homolog A [Homo sapiens]                              65   1e-10
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    64   5e-10
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      62   1e-09
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      62   1e-09
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       62   1e-09
gi|45827729 scribble isoform b [Homo sapiens]                          61   3e-09
gi|45827731 scribble isoform a [Homo sapiens]                          61   3e-09
gi|148746189 multiple PDZ domain protein [Homo sapiens]                60   5e-09
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi...    59   1e-08
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...    59   1e-08
gi|112382257 InaD-like [Homo sapiens]                                  59   1e-08
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]         58   3e-08
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    58   3e-08
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...    58   3e-08

>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score = 1079 bits (2791), Expect = 0.0
 Identities = 540/540 (100%), Positives = 540/540 (100%)

Query: 1   MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELE 60
           MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELE
Sbjct: 1   MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELE 60

Query: 61  PALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVK 120
           PALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVK
Sbjct: 61  PALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVK 120

Query: 121 QEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV 180
           QEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV
Sbjct: 121 QEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV 180

Query: 181 QALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNST 240
           QALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNST
Sbjct: 181 QALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNST 240

Query: 241 KDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIM 300
           KDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIM
Sbjct: 241 KDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIM 300

Query: 301 ALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLY 360
           ALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLY
Sbjct: 301 ALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLY 360

Query: 361 DCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVE 420
           DCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVE
Sbjct: 361 DCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVE 420

Query: 421 THRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSIL 480
           THRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSIL
Sbjct: 421 THRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSIL 480

Query: 481 YRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV 540
           YRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV
Sbjct: 481 YRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV 540


>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score =  587 bits (1512), Expect = e-167
 Identities = 310/556 (55%), Positives = 398/556 (71%), Gaps = 38/556 (6%)

Query: 3   VAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPA 62
           +A A AAA AGPA A   RA ++GL+E+L+R+RW +V+  LS ++L L+ +  AA     
Sbjct: 1   MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAA----- 55

Query: 63  LGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPA----PPRGPAGEAGA--------- 109
                 A+NG+      G +  GS  RG G   P A    PP  PAG   A         
Sbjct: 56  ------AYNGI------GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVP 103

Query: 110 ---SPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSV 166
              S   R V+V+KQE GGLGISIKGG+EN+MPILISKIF GLAADQ++AL +GDAILSV
Sbjct: 104 ESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSV 163

Query: 167 NGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFS 226
           NG DLR ATHD+AVQALKRAGKEVLLEVK++RE TPY+KK S VS++ WE   P+SP   
Sbjct: 164 NGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLG 223

Query: 227 GS-EDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDT 285
           GS  D  S +  +  +DRK IPLKMC+  R++++ D ENR +E+HSPD+++T+ILR KD+
Sbjct: 224 GSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDS 283

Query: 286 ATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQW 345
           ATA +WF AIH+N+  LL +V+AE+   LG T  AG S+E++H+ WLAE+   +  ++QW
Sbjct: 284 ATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAG-SREIRHLGWLAEKVPGES-KKQW 341

Query: 346 RPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATR 405
           +P L+ +TEKDLL+YD MP  ++AW SP H+YPL+ATRLVHSG G  SP  G DL+FATR
Sbjct: 342 KPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATR 401

Query: 406 TGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYEN 465
           TG+RQGIE HLFR ET RDLS WTR +VQGCH +AELI E+S  C    QE RLTIHYEN
Sbjct: 402 TGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYEN 461

Query: 466 GFTISRE--NGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVF 523
           GF+I+ E   G     + + P+E+LKMS+DDGIR LYLDFGG +GE+ +DLHSCPKPIVF
Sbjct: 462 GFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVF 521

Query: 524 VLHTFLSAKVTRMGLL 539
           ++H+FLSAK+TR+GL+
Sbjct: 522 IIHSFLSAKITRLGLV 537


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score =  429 bits (1102), Expect = e-120
 Identities = 251/541 (46%), Positives = 336/541 (62%), Gaps = 54/541 (9%)

Query: 16  MAVWTRATKAGLVELLLR-------ERWVRVVAELSGESLSLTGDAAAAELEPALGPAAA 68
           MA   RA + GL+EL          ERW RV+  L+ + L+++                 
Sbjct: 1   MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVS----------------- 43

Query: 69  AFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPV---------RRVRVV 119
                P  G  G   PG+P         PA   G A E GA PP          RRV V 
Sbjct: 44  -----PADGDPGPE-PGAPRE-----QEPAQLNG-AAEPGAGPPQLPEALLLQRRRVTVR 91

Query: 120 KQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           K +AGGLGISIKGGREN+MPILISKIF GLAADQ+ AL +GDAILSVNG DL  ATHD+A
Sbjct: 92  KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEA 151

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNS 239
           VQ LK+ GKEV+LEVK++++V+PY K  +  + + W+  +P +        S  P  +N 
Sbjct: 152 VQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWD--SPPASPLQRQPSSPGPTPRNF 209

Query: 240 TKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNI 299
           + + K + LKM + ++  +  D E R +E+ S D ++TL LR KD A+A SW  AI   +
Sbjct: 210 S-EAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQV 268

Query: 300 MALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLL 359
             L P+V  EL A+L ATSTA GS+++K I WL EQ    G      P L  +TEK+LLL
Sbjct: 269 NTLTPRVKDELQALLAATSTA-GSQDIKQIGWLTEQLPSGG----TAPTLALLTEKELLL 323

Query: 360 YDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRV 419
           Y  +P TR+A + P  + PL+ATRLVHSG    S    ++L+FA RTG+R G++ HLF V
Sbjct: 324 YLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSV 383

Query: 420 ETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTI-SRENGGSSS 478
           E+ ++L++WTR LV GCH AAE ++EVS  C  NG+   L++H + GFT+ + E G + +
Sbjct: 384 ESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARA 443

Query: 479 ILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGL 538
           +L R PFE+L+MS+DDG   L+LDFGG EGE+ +DLHSCPK IVF++H+FLSAKVTR+GL
Sbjct: 444 VLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGL 503

Query: 539 L 539
           L
Sbjct: 504 L 504


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score =  142 bits (357), Expect = 1e-33
 Identities = 123/458 (26%), Positives = 201/458 (43%), Gaps = 49/458 (10%)

Query: 114 RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173
           R V + +Q  GGLG+SIKGG E+ +P++ISKIF   AADQ+  L +GDA+L VNG  +  
Sbjct: 72  RTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVEN 131

Query: 174 ATHDQAVQALKRAGKEVLLEVKFIREVTPYIK-----------------KPSLVSDLPWE 216
           ATH++ V  L+ AG EV + V+++RE   ++K                  P   S L   
Sbjct: 132 ATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLN 191

Query: 217 G----AAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAAR-NLSMPDLENRLIELHS 271
           G     AP SPS   ++D   P+++    D   +PL M   +R       L     E+ +
Sbjct: 192 GNSSTTAPSSPSSPIAKD---PRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLA 248

Query: 272 PDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAW 331
            D  ++ ILR         W  A+  NI  L       L  M  A      S +V H+ W
Sbjct: 249 LDGVSSGILRFYTAQDGTDWLRAVSANIREL------TLQNMKMANKCCSPSDQVVHMGW 302

Query: 332 LAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRL-VHS--- 387
           + E+ +     Q +RP  +A+      ++   P +   W     +Y L      VH    
Sbjct: 303 VNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWL 362

Query: 388 GSGC---RSPSLG-SDLTFATRTGSRQGI-----EMHLFRVETHRDLSSWTRILVQGCHA 438
              C    +  LG  D  F  +      I     + H+F VE   +L+ W +   +    
Sbjct: 363 TEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFM 422

Query: 439 AAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDG--- 495
             +     +  C   G+ +  T+ +  GFT       + ++L+R+ F +LK S+DDG   
Sbjct: 423 EVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESK--TKNVLWRFKFSQLKGSSDDGKTR 480

Query: 496 IRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKV 533
           ++ L+ +    + E+        + ++  +H+F++AKV
Sbjct: 481 VKLLFQNLDTKQIEMKELEFQDLRAVLHCIHSFIAAKV 518


>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
          Length = 517

 Score =  125 bits (315), Expect = 8e-29
 Identities = 115/448 (25%), Positives = 195/448 (43%), Gaps = 44/448 (9%)

Query: 114 RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173
           R V + +Q  GG G+SIKGG E+ +P+++SKI     A+ S  L +GDAIL +NG ++R+
Sbjct: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115

Query: 174 ATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSG- 232
             H++ VQ L+ AG+EV L V F++    ++K P L  D     +   S + S   DSG 
Sbjct: 116 CRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLP-LNEDCACAPSDQSSGTSSPLCDSGL 174

Query: 233 -SPKHQNSTK--------------------DRKIIPLKMCFAARNLSMPDLENR-LIELH 270
               H N+T                     D ++IPL     ++ +   DL  +   ++ 
Sbjct: 175 HLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVI 234

Query: 271 SPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIA 330
           + D   T I++C        W  AI TNI  L    + ++N           ++++ ++ 
Sbjct: 235 AVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPV------NQQIVYMG 288

Query: 331 WLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAW--ASPCHSYPLVATRLVHSG 388
           W   + +     + + P  +A+    L  +   P T   W  A    S   +  +++   
Sbjct: 289 WCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKIL--- 345

Query: 389 SGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSL 448
              +   L           S  G +++ F VE   DL+ W R          E I+  + 
Sbjct: 346 ---KDSDLLDRRKQCFTVQSESGEDLY-FSVELESDLAQWERAFQTATFLEVERIQCKTY 401

Query: 449 GCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEG 508
            C+L    + LTI +  GF     +  + ++L+RY F +LK S+DDG   +   F  P+ 
Sbjct: 402 ACVLESHLMGLTIDFSTGFICF--DAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDT 459

Query: 509 ---ELTMDLHSCPKPIVFVLHTFLSAKV 533
              E      S    ++  +H+F +AKV
Sbjct: 460 KQIEAKELEFSNLFAVLHCIHSFFAAKV 487


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 43/103 (41%), Positives = 66/103 (64%)

Query: 95  SPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQS 154
           +PP   +    ++    P+R+V ++K++  GLGISI GG+E+ +PILIS+I PG  AD+ 
Sbjct: 268 APPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRC 327

Query: 155 RALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFI 197
             L +GDAIL+VNG +LR   H +AV  L +   E+  EV ++
Sbjct: 328 GGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 370


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 43/103 (41%), Positives = 66/103 (64%)

Query: 95  SPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQS 154
           +PP   +    ++    P+R+V ++K++  GLGISI GG+E+ +PILIS+I PG  AD+ 
Sbjct: 260 APPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRC 319

Query: 155 RALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFI 197
             L +GDAIL+VNG +LR   H +AV  L +   E+  EV ++
Sbjct: 320 GGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYV 362


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 57/152 (37%), Positives = 80/152 (52%), Gaps = 5/152 (3%)

Query: 78  GAGDSLPGSPSRGLGPPSPPAP-PRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGREN 136
           GA +S    P+    PP+  +P PR    E   +   R++ ++ + + GLG +I GG + 
Sbjct: 348 GAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKI-ILHKGSTGLGFNIVGGEDG 406

Query: 137 RMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKF 196
              I +S I  G  AD S  LR GD ILSVNG +LR ATH+QA  ALKRAG+ V +  ++
Sbjct: 407 E-GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQY 465

Query: 197 IREVTPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
             E   Y +  S + DL  +       S SGS
Sbjct: 466 RPE--EYSRFESKIHDLREQMMNSSMSSGSGS 495



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 5/83 (6%)

Query: 118 VVKQEAGGLGISIKGGREN-RMP----ILISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
           V+++   GLG SI GG +N  +P    I I+KI PG AA     L + D +L VN  D+ 
Sbjct: 133 VLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192

Query: 173 QATHDQAVQALKRAGKEVLLEVK 195
           +  H +AV+ALK AG  V L V+
Sbjct: 193 EVVHSRAVEALKEAGPVVRLVVR 215



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 7/91 (7%)

Query: 111 PPVRRVRVVKQEAG--GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAI 163
           PP   +  V    G  GLG SI GG  N+       I I+KI  G AA +   L++GD +
Sbjct: 219 PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
           L+VN T+L+   H++AV +LK     V L+V
Sbjct: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKV 309


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 56/162 (34%), Positives = 78/162 (48%), Gaps = 7/162 (4%)

Query: 67  AAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGL 126
           A  F+G     G G +   +  R     + P     P G+A     +    ++ + + GL
Sbjct: 4   ARKFSGSGLAMGLGSASASAWRRASQRWAWPLRSLRPGGDAREPRKI----ILHKGSTGL 59

Query: 127 GISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRA 186
           G +I GG +    I +S I  G  AD S  LR GD ILSVNG +LR ATH+QA  ALKRA
Sbjct: 60  GFNIVGGEDGE-GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRA 118

Query: 187 GKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
           G+ V +  ++  E   Y +  S + DL  +       S SGS
Sbjct: 119 GQSVTIVAQYRPE--EYSRFESKIHDLREQMMNSSMSSGSGS 158


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 42/97 (43%), Positives = 57/97 (58%), Gaps = 2/97 (2%)

Query: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163
           A   G S P R V + K E G LG +I GG+E   PI IS+I PG  AD+   L+ GD +
Sbjct: 83  AASEGHSHP-RVVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQL 140

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
           LSVNG  +    H++AV+ LK A  +V L V++  +V
Sbjct: 141 LSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKV 177


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 39/97 (40%), Positives = 54/97 (55%), Gaps = 3/97 (3%)

Query: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163
           A E  A P   RV  + +   GLG +I GG+E   PI IS++ PG  AD+   L+ GD +
Sbjct: 84  ASEGHAHP---RVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQL 140

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
           LSVNG  +    H++AV+ LK A   V L V++   V
Sbjct: 141 LSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRV 177


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 58/148 (39%), Positives = 74/148 (50%), Gaps = 9/148 (6%)

Query: 86  SPSRGLGPPSPPAPPR-GPAGEA--GASPPVRRVRVVKQEAG--GLGISIKGGRENRMPI 140
           SPS  LG  +P +P R  P  +A  G     R  R V    G  GLG +I GG +    I
Sbjct: 432 SPSSFLGQ-TPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGE-GI 489

Query: 141 LISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
            IS I  G  AD S  LR GD I+SVN  DLR A+H+QA  ALK AG+ V +  ++  E 
Sbjct: 490 FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPE- 548

Query: 201 TPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
             Y +  + + DL  +       S SGS
Sbjct: 549 -EYSRFEAKIHDLREQMMNSSISSGSGS 575



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 41/91 (45%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 125 GLGISIKGGRENR-----MPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI  G AA Q   LR+ D IL VN  D+R  TH +A
Sbjct: 233 GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKA 292

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKPSLV 210
           V+ALK AG  V L VK  + V+  I +  L+
Sbjct: 293 VEALKEAGSIVRLYVKRRKPVSEKIMEIKLI 323



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/90 (36%), Positives = 50/90 (55%), Gaps = 6/90 (6%)

Query: 110 SPPVRRVRVVKQEAGGLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAIL 164
           S  +  ++++K   G LG SI GG  N+       I ++KI  G AA +   L++GD +L
Sbjct: 314 SEKIMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372

Query: 165 SVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
           +VN   L + TH++AV ALK     V L+V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 58/148 (39%), Positives = 74/148 (50%), Gaps = 9/148 (6%)

Query: 86  SPSRGLGPPSPPAPPR-GPAGEA--GASPPVRRVRVVKQEAG--GLGISIKGGRENRMPI 140
           SPS  LG  +P +P R  P  +A  G     R  R V    G  GLG +I GG +    I
Sbjct: 432 SPSSFLGQ-TPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGE-GI 489

Query: 141 LISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
            IS I  G  AD S  LR GD I+SVN  DLR A+H+QA  ALK AG+ V +  ++  E 
Sbjct: 490 FISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPE- 548

Query: 201 TPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
             Y +  + + DL  +       S SGS
Sbjct: 549 -EYSRFEAKIHDLREQMMNSSISSGSGS 575



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 41/91 (45%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 125 GLGISIKGGRENR-----MPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI  G AA Q   LR+ D IL VN  D+R  TH +A
Sbjct: 233 GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKA 292

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKPSLV 210
           V+ALK AG  V L VK  + V+  I +  L+
Sbjct: 293 VEALKEAGSIVRLYVKRRKPVSEKIMEIKLI 323



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/90 (36%), Positives = 50/90 (55%), Gaps = 6/90 (6%)

Query: 110 SPPVRRVRVVKQEAGGLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAIL 164
           S  +  ++++K   G LG SI GG  N+       I ++KI  G AA +   L++GD +L
Sbjct: 314 SEKIMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLL 372

Query: 165 SVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
           +VN   L + TH++AV ALK     V L+V
Sbjct: 373 AVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 61/225 (27%), Positives = 94/225 (41%), Gaps = 24/225 (10%)

Query: 43  LSGESLSLTGDAAAAELEPALGPAAAAFNGLPNGG--GAGDSLPGSPSRGLGPPSPPAPP 100
           L GE L         +++P+LG    A      G    AG+++      GL   +P    
Sbjct: 53  LHGEPLPDHCQGTGGQIDPSLGRGGRAKQRGSRGSWWAAGETIANMLC-GLSRETPGEAD 111

Query: 101 RGP-------AGEAGASPPVRR------------VRVVKQEAGGLGISIKGGRENRMPIL 141
            GP       AG A  S   RR            V ++K+E   LG++I GG +      
Sbjct: 112 DGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPR 171

Query: 142 ISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVT 201
           +S + PG  A +S  L +GD I SVNG  L +  HD+ +  LK  G+ V+LEV++     
Sbjct: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPP 231

Query: 202 PYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRKII 246
                P ++S         +  SF      G+  H++  K R ++
Sbjct: 232 APENNPRIISKTVDVSLYKEGNSFGFVLRGGA--HEDGHKSRPLV 274



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 12/110 (10%)

Query: 91  LGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGREN----RMPILISKIF 146
           L PP+P   PR  +     S        + +E    G  ++GG         P++++ + 
Sbjct: 228 LPPPAPENNPRIISKTVDVS--------LYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVR 279

Query: 147 PGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKF 196
           PG  AD+  +L++GD +LSV+G  L  A+H  A+  L++   E L +V++
Sbjct: 280 PGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEY 329



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 27/77 (35%), Positives = 46/77 (59%)

Query: 119 VKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQ 178
           +K+  G LGI+I G  E   PI+IS +     A+++ A+ +GD IL++N   L+     +
Sbjct: 757 LKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSE 816

Query: 179 AVQALKRAGKEVLLEVK 195
           A+  L+ AG+ V L++K
Sbjct: 817 AIHLLQVAGETVTLKIK 833



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 2/93 (2%)

Query: 103 PAGEAGASPPVRRVRVVKQEAGGLGISIKG-GRENRMPILISKIFPGLAADQSRALRLGD 161
           P   A AS P+  V +VK     LGIS+      N+  I I +I P    D+S AL  GD
Sbjct: 334 PDTVANASGPLM-VEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGD 392

Query: 162 AILSVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
            ILS++GT +   +  +A + L    ++V LE+
Sbjct: 393 HILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 7/101 (6%)

Query: 102 GPAGEAGASPPVRRVRVVKQEAGGLGISIKGG----RENRMPILISKIFPGLAADQSRAL 157
           GP G+         V +      G G+ ++GG         P L+  I P   A++   L
Sbjct: 542 GPGGQI-VHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLL 600

Query: 158 RLGDAILSVNGTDLRQATHDQAVQALKRA--GKEVLLEVKF 196
           ++GD +LS+NG      T ++A Q L+ A    +V+LEV+F
Sbjct: 601 QVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEF 641



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 5/123 (4%)

Query: 116 VRVVKQEAGGLGISIKGGRENR-MPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQA 174
           V++ K+ +  LGI+I      R  P++IS I  G  A ++  L  GD +L+++   L   
Sbjct: 656 VKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNC 715

Query: 175 THDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVS---DLPWEGAAPQSPSFSGSEDS 231
             + AVQ L++    V L+++   + +  ++    VS   +L   G  P   + SG+E+ 
Sbjct: 716 PMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELKRYG-GPLGITISGTEEP 774

Query: 232 GSP 234
             P
Sbjct: 775 FDP 777


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 42/92 (45%), Positives = 54/92 (58%), Gaps = 2/92 (2%)

Query: 105 GEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAIL 164
           GE       RR+ V+ + + GLG +I GG +    I IS I  G  AD S  LR GD IL
Sbjct: 346 GEEDIPREPRRI-VIHRGSTGLGFNIVGGEDGE-GIFISFILAGGPADLSGELRKGDQIL 403

Query: 165 SVNGTDLRQATHDQAVQALKRAGKEVLLEVKF 196
           SVNG DLR A+H+QA  ALK AG+ V +  ++
Sbjct: 404 SVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 435



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 38/75 (50%), Positives = 45/75 (60%), Gaps = 5/75 (6%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI PG AA Q   LR+ D+IL VN  D+R+ TH  A
Sbjct: 117 GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 176

Query: 180 VQALKRAGKEVLLEV 194
           V+ALK AG  V L V
Sbjct: 177 VEALKEAGSIVRLYV 191



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 36/91 (39%), Positives = 47/91 (51%), Gaps = 7/91 (7%)

Query: 111 PPVRRVRVVKQEAG--GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAI 163
           PP  +V  +K   G  GLG SI GG  N+       I ++KI  G AA +   L++GD I
Sbjct: 196 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
           L+VN   L    H+ AV ALK     V L+V
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 42/92 (45%), Positives = 54/92 (58%), Gaps = 2/92 (2%)

Query: 105 GEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAIL 164
           GE       RR+ V+ + + GLG +I GG +    I IS I  G  AD S  LR GD IL
Sbjct: 300 GEEDIPREPRRI-VIHRGSTGLGFNIVGGEDGE-GIFISFILAGGPADLSGELRKGDQIL 357

Query: 165 SVNGTDLRQATHDQAVQALKRAGKEVLLEVKF 196
           SVNG DLR A+H+QA  ALK AG+ V +  ++
Sbjct: 358 SVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 389



 Score = 62.8 bits (151), Expect = 8e-10
 Identities = 38/75 (50%), Positives = 45/75 (60%), Gaps = 5/75 (6%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI PG AA Q   LR+ D+IL VN  D+R+ TH  A
Sbjct: 71  GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 130

Query: 180 VQALKRAGKEVLLEV 194
           V+ALK AG  V L V
Sbjct: 131 VEALKEAGSIVRLYV 145



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 36/91 (39%), Positives = 47/91 (51%), Gaps = 7/91 (7%)

Query: 111 PPVRRVRVVKQEAG--GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAI 163
           PP  +V  +K   G  GLG SI GG  N+       I ++KI  G AA +   L++GD I
Sbjct: 150 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
           L+VN   L    H+ AV ALK     V L+V
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 38/97 (39%), Positives = 55/97 (56%), Gaps = 2/97 (2%)

Query: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163
           A   G S P  RV  + +   GLG ++ GG+E   PI IS+I PG  A++   L+ GD +
Sbjct: 98  AASEGHSHP--RVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQL 155

Query: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
           LSVNG  +    H++AV+ LK A   V L V++  +V
Sbjct: 156 LSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKV 192


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 41/131 (31%), Positives = 64/131 (48%), Gaps = 12/131 (9%)

Query: 119  VKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQ 178
            +++ A G G SI+GGRE +M + + ++     A ++  +R+GD I+ +NG   R  TH +
Sbjct: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209

Query: 179  AVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWE---GAAPQSPSFSGSEDSG--- 232
            A++ +K  G+ V L +K      P   +P+     PW     AAP  P    S D G   
Sbjct: 1210 AIELIKSGGRRVRLLLKRGTGQVPEYDEPA-----PWSSPAAAAPGLPEVGVSLDDGLAP 1264

Query: 233  -SPKHQNSTKD 242
             SP H     D
Sbjct: 1265 FSPSHPAPPSD 1275



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 43/140 (30%), Positives = 59/140 (42%), Gaps = 12/140 (8%)

Query: 94   PSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISI-------KGGRENRMPILISKIF 146
            PS  A P  P G A  S     V + ++E  G G  I       + G    +P  I +I 
Sbjct: 901  PSSNASP--PEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRII 958

Query: 147  PGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKK 206
             G  AD+   L++GD IL+VNG  +    H   V+ +K AG  V L +    E+      
Sbjct: 959  DGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSA 1018

Query: 207  PSLVSDLPWEGAAP---QSP 223
            PS     P    +P   QSP
Sbjct: 1019 PSSEKQSPMAQQSPLAQQSP 1038



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 1/114 (0%)

Query: 88  SRGLGPPSPPAPPRGPAGEAGASPPVRRVRV-VKQEAGGLGISIKGGRENRMPILISKIF 146
           SR +       PPR       + P  + + V +++   G G  I GG E   PILI  + 
Sbjct: 749 SRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVI 808

Query: 147 PGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
              +AD+   L  GD ++ V+G  +   TH   +  +  A +   + +   R+V
Sbjct: 809 AMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKV 862



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 24/60 (40%), Positives = 28/60 (46%), Gaps = 2/60 (3%)

Query: 54   AAAAELEPALGPAAAAFNGLPNGGGAGD-SLPGSPSRGLGPPSPPAPPRG-PAGEAGASP 111
            AA +EL    GP AA     P GGG+G     G      GP   P PP G PA +A  +P
Sbjct: 1372 AAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAP 1431


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/111 (39%), Positives = 61/111 (54%), Gaps = 3/111 (2%)

Query: 118 VVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHD 177
           V+ + + GLG +I GG +    I +S I  G  AD S  L+ GD ILSVNG DLR A+H+
Sbjct: 320 VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378

Query: 178 QAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
           QA  ALK AG+ V +  ++  E   Y +  + + DL  +       S SGS
Sbjct: 379 QAAAALKGAGQTVTIIAQYQPE--DYARFEAKIHDLREQMMNHSMSSGSGS 427



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 36/81 (44%), Positives = 47/81 (58%), Gaps = 5/81 (6%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI PG AA +   LR+ D IL VN  D+ + +H +A
Sbjct: 56  GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 115

Query: 180 VQALKRAGKEVLLEVKFIREV 200
           V+ALK AG  V L V+  R +
Sbjct: 116 VEALKEAGSIVRLYVRRRRPI 136



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 7/88 (7%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG  N+       I ++KI  G AA +   L++GD +L VN   L + TH++A
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKP 207
           V  LK   + V L+V   +  T Y+  P
Sbjct: 211 VAILKNTSEVVYLKVG--KPTTIYMTDP 236


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/111 (39%), Positives = 61/111 (54%), Gaps = 3/111 (2%)

Query: 118 VVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHD 177
           V+ + + GLG +I GG +    I +S I  G  AD S  L+ GD ILSVNG DLR A+H+
Sbjct: 528 VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586

Query: 178 QAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
           QA  ALK AG+ V +  ++  E   Y +  + + DL  +       S SGS
Sbjct: 587 QAAAALKGAGQTVTIIAQYQPE--DYARFEAKIHDLREQMMNHSMSSGSGS 635



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 36/81 (44%), Positives = 47/81 (58%), Gaps = 5/81 (6%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI PG AA +   LR+ D IL VN  D+ + +H +A
Sbjct: 212 GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 271

Query: 180 VQALKRAGKEVLLEVKFIREV 200
           V+ALK AG  V L V+  R +
Sbjct: 272 VEALKEAGSIVRLYVRRRRPI 292



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 7/88 (7%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG  N+       I ++KI  G AA +   L++GD +L VN   L + TH++A
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKP 207
           V  LK   + V L+V   +  T Y+  P
Sbjct: 367 VAILKNTSEVVYLKVG--KPTTIYMTDP 392


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/111 (39%), Positives = 61/111 (54%), Gaps = 3/111 (2%)

Query: 118 VVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHD 177
           V+ + + GLG +I GG +    I +S I  G  AD S  L+ GD ILSVNG DLR A+H+
Sbjct: 423 VLHKGSTGLGFNIVGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481

Query: 178 QAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGS 228
           QA  ALK AG+ V +  ++  E   Y +  + + DL  +       S SGS
Sbjct: 482 QAAAALKGAGQTVTIIAQYQPE--DYARFEAKIHDLREQMMNHSMSSGSGS 530



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 36/81 (44%), Positives = 47/81 (58%), Gaps = 5/81 (6%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG +N        I I+KI PG AA +   LR+ D IL VN  D+ + +H +A
Sbjct: 107 GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 166

Query: 180 VQALKRAGKEVLLEVKFIREV 200
           V+ALK AG  V L V+  R +
Sbjct: 167 VEALKEAGSIVRLYVRRRRPI 187



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 7/88 (7%)

Query: 125 GLGISIKGGRENRM-----PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQA 179
           GLG SI GG  N+       I ++KI  G AA +   L++GD +L VN   L + TH++A
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 180 VQALKRAGKEVLLEVKFIREVTPYIKKP 207
           V  LK   + V L+V   +  T Y+  P
Sbjct: 262 VAILKNTSEVVYLKVG--KPTTIYMTDP 287


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 53/144 (36%), Positives = 69/144 (47%), Gaps = 30/144 (20%)

Query: 79   AGDSLPGSPSRGLGPPS---------------PPAPPRGPAGEAGASP---PVRRVRVVK 120
            AG  LP SP     PP+               P  P   P+  A A     PV  +R+ +
Sbjct: 950  AGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR 1009

Query: 121  QEAGGLGISIKGGRENRMP--------ILISKIFP-GLAADQSRALRLGDAILSVNGTDL 171
               G LG+SI GG ++           + ISK+ P GLAA     LR+GD IL+VNG D+
Sbjct: 1010 A-GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG--LRVGDRILAVNGQDV 1066

Query: 172  RQATHDQAVQALKRAGKEVLLEVK 195
            R ATH +AV AL R   E+ L V+
Sbjct: 1067 RDATHQEAVSALLRPCLELSLLVR 1090



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 40/112 (35%), Positives = 55/112 (49%), Gaps = 15/112 (13%)

Query: 89  RGLGPPSPPAPPRGPAGEAGASPPVRR--VRVVKQEAGGLGISIKGG------RENRMPI 140
           RG G   P  PP  P        P+R+  V  + +   GLG SI GG      R     I
Sbjct: 840 RGGGLRLPLLPPESPG-------PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGI 892

Query: 141 LISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLL 192
            +S+I  G AA ++  L++GD +LS+NG D+ +A HD AV  L  A   + L
Sbjct: 893 FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 34/90 (37%), Positives = 51/90 (56%), Gaps = 7/90 (7%)

Query: 119 VKQEAGGLGISIKGGRENRM------PILISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
           + ++ GGLGISI GG+ +         I IS++     A ++  +R+GD +L VNG  L+
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDKLLEVNGVALQ 789

Query: 173 QATHDQAVQALKRAGKEVLLEVKFIREVTP 202
            A H +AV+AL+ AG  V + V   R V P
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMVEP 819



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 9/88 (10%)

Query: 109  ASPPVRRVRVVKQEAGGLGISIKGGREN-----RMP----ILISKIFPGLAADQSRALRL 159
            A P +R + + K     LGISI+GG        R P    I ISK+ P  AA +   LR+
Sbjct: 1094 APPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 160  GDAILSVNGTDLRQATHDQAVQALKRAG 187
            G  +L VN   L   TH +AVQ L+  G
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181



 Score = 33.1 bits (74), Expect = 0.66
 Identities = 28/76 (36%), Positives = 37/76 (48%), Gaps = 14/76 (18%)

Query: 42   ELSGESLSL---TGDAAAAELEP--------ALGPAAAAFNGLPNG--GGAGDSLPGSPS 88
            EL G++L       +AA   L+P        A  P+A +   +P+G  GG     P SPS
Sbjct: 1241 ELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPS 1300

Query: 89   RGLGPPSPPAPPRGPA 104
             G  PPSPP+P   PA
Sbjct: 1301 -GQQPPSPPSPDELPA 1315


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 53/144 (36%), Positives = 69/144 (47%), Gaps = 30/144 (20%)

Query: 79   AGDSLPGSPSRGLGPPS---------------PPAPPRGPAGEAGASP---PVRRVRVVK 120
            AG  LP SP     PP+               P  P   P+  A A     PV  +R+ +
Sbjct: 950  AGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR 1009

Query: 121  QEAGGLGISIKGGRENRMP--------ILISKIFP-GLAADQSRALRLGDAILSVNGTDL 171
               G LG+SI GG ++           + ISK+ P GLAA     LR+GD IL+VNG D+
Sbjct: 1010 A-GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG--LRVGDRILAVNGQDV 1066

Query: 172  RQATHDQAVQALKRAGKEVLLEVK 195
            R ATH +AV AL R   E+ L V+
Sbjct: 1067 RDATHQEAVSALLRPCLELSLLVR 1090



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 40/112 (35%), Positives = 55/112 (49%), Gaps = 15/112 (13%)

Query: 89  RGLGPPSPPAPPRGPAGEAGASPPVRR--VRVVKQEAGGLGISIKGG------RENRMPI 140
           RG G   P  PP  P        P+R+  V  + +   GLG SI GG      R     I
Sbjct: 840 RGGGLRLPLLPPESPG-------PLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGI 892

Query: 141 LISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLL 192
            +S+I  G AA ++  L++GD +LS+NG D+ +A HD AV  L  A   + L
Sbjct: 893 FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 34/90 (37%), Positives = 51/90 (56%), Gaps = 7/90 (7%)

Query: 119 VKQEAGGLGISIKGGRENRM------PILISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
           + ++ GGLGISI GG+ +         I IS++     A ++  +R+GD +L VNG  L+
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARA-GVRVGDKLLEVNGVALQ 789

Query: 173 QATHDQAVQALKRAGKEVLLEVKFIREVTP 202
            A H +AV+AL+ AG  V + V   R V P
Sbjct: 790 GAEHHEAVEALRGAGTAVQMRVWRERMVEP 819



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 9/88 (10%)

Query: 109  ASPPVRRVRVVKQEAGGLGISIKGGREN-----RMP----ILISKIFPGLAADQSRALRL 159
            A P +R + + K     LGISI+GG        R P    I ISK+ P  AA +   LR+
Sbjct: 1094 APPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 160  GDAILSVNGTDLRQATHDQAVQALKRAG 187
            G  +L VN   L   TH +AVQ L+  G
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181



 Score = 33.1 bits (74), Expect = 0.66
 Identities = 28/76 (36%), Positives = 37/76 (48%), Gaps = 14/76 (18%)

Query: 42   ELSGESLSL---TGDAAAAELEP--------ALGPAAAAFNGLPNG--GGAGDSLPGSPS 88
            EL G++L       +AA   L+P        A  P+A +   +P+G  GG     P SPS
Sbjct: 1241 ELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPS 1300

Query: 89   RGLGPPSPPAPPRGPA 104
             G  PPSPP+P   PA
Sbjct: 1301 -GQQPPSPPSPDELPA 1315


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 39/109 (35%), Positives = 59/109 (54%), Gaps = 9/109 (8%)

Query: 114  RRVRVVKQEAGGLGISIKGGR---------ENRMPILISKIFPGLAADQSRALRLGDAIL 164
            RRV + ++ +  LGISI GGR         E    I I  +     A ++  L+ GD I+
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209

Query: 165  SVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDL 213
             V+G DLR A+H+QAV+A+++AG  V+  V+ I         PSL+ +L
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNL 1258



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 47/149 (31%), Positives = 68/149 (45%), Gaps = 9/149 (6%)

Query: 62   ALGPAAAAFNGLPNGGGAGDSLP--GSPS----RGLGPPSPPAPPRGPAGEAGASPPVRR 115
            A+  AA A +G          +P  GSP     R     S PA            P    
Sbjct: 1569 AVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCET 1628

Query: 116  VRVVKQEAGGLGISIKGGRENRM-PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQA 174
               + +   GLG+SI GG +  +  I+I +++   AA +   L  GD IL VNG DLR+A
Sbjct: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688

Query: 175  THDQAVQALKRAGKEVLLEVKFIREVTPY 203
            THD+A+  L++  + V L +   R+  PY
Sbjct: 1689 THDEAINVLRQTPQRVRLTL--YRDEAPY 1715



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 58/208 (27%), Positives = 97/208 (46%), Gaps = 26/208 (12%)

Query: 43   LSGESL-SLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPR 101
            ++GE + + T +A AA L+ + G + ++F    +G    +SL  S  +            
Sbjct: 1775 VNGEDVRNATQEAVAALLKVSEG-SLSSFTFPLSGSSTSESLESSSKKN----------- 1822

Query: 102  GPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRM---PILISKIFPGLAADQSRALR 158
                 A     +R V + K     LGISI GG  + +   PI I+ + P   A Q++ LR
Sbjct: 1823 ---ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879

Query: 159  LGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKF---IREVTPYIKKPSLVSDLPW 215
            +GD I+++ GT     TH QAV  LK A   + ++V     +  VT + ++P+  S L +
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPA-SSSLSF 1938

Query: 216  EGAAPQSPSFSGSEDSGSPKHQNSTKDR 243
             G    S      +D G P+ ++ T +R
Sbjct: 1939 TGLTSSS---IFQDDLGPPQCKSITLER 1963



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 3/87 (3%)

Query: 111  PPVRRVRVVKQEAGGLGISIKGGR---ENRMPILISKIFPGLAADQSRALRLGDAILSVN 167
            PP  +   +++   GLG SI GG       +PI +  +F   AA +   L+ GD I++VN
Sbjct: 1953 PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVN 2012

Query: 168  GTDLRQATHDQAVQALKRAGKEVLLEV 194
            G  L   TH++AV  LKR    V L V
Sbjct: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 2/73 (2%)

Query: 122 EAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQ 181
           +  GLG  I GG+     +++  I PG  ADQ   L  GD IL +  TDL   + +Q  Q
Sbjct: 263 DGSGLGFGIIGGKATG--VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320

Query: 182 ALKRAGKEVLLEV 194
            L++ G  V L +
Sbjct: 321 VLRQCGNRVKLMI 333



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 1/69 (1%)

Query: 116  VRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 175
            + + K+   GLG+SI G R N   + +S I  G  AD    L  GD IL VNG D+R AT
Sbjct: 1726 IELQKKPGKGLGLSIVGKR-NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784

Query: 176  HDQAVQALK 184
             +     LK
Sbjct: 1785 QEAVAALLK 1793



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 4/72 (5%)

Query: 125 GLGISIKG--GRENRMP--ILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV 180
           GLGI+I G  G +   P  I +  I    A +    +++GD I++V+GT+L+  T+ QAV
Sbjct: 386 GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAV 445

Query: 181 QALKRAGKEVLL 192
           + L+  G+ VLL
Sbjct: 446 EVLRHTGQTVLL 457



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 5/86 (5%)

Query: 116  VRVVKQEAG--GLGISIKGGRE-NRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
            + +++ E G  GLG+S+ G ++ +RM + I  I P  AA +   L++ D +L +NG  L 
Sbjct: 1348 LHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407

Query: 173  QATHDQAVQALKRAGKEVLLEVKFIR 198
              +H  A   +K A  +V  ++ FIR
Sbjct: 1408 GRSHQNASSIIKCAPSKV--KIIFIR 1431



 Score = 35.8 bits (81), Expect = 0.10
 Identities = 23/66 (34%), Positives = 37/66 (56%), Gaps = 4/66 (6%)

Query: 125 GLGISIKGGRENRMP----ILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAV 180
           GLG SI   ++   P    I+I  + PG  A++   L  GD ++ VN  +L  ++ ++AV
Sbjct: 709 GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAV 768

Query: 181 QALKRA 186
           +ALK A
Sbjct: 769 EALKGA 774



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 23/71 (32%), Positives = 29/71 (40%), Gaps = 3/71 (4%)

Query: 122 EAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQ 181
           E  GLGIS++    +     I  + P      S  L  GD +L VNG  L    H   V 
Sbjct: 561 ENSGLGISLEATVGHHF---IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVN 617

Query: 182 ALKRAGKEVLL 192
            LK    EV +
Sbjct: 618 ILKELPIEVTM 628



 Score = 30.4 bits (67), Expect = 4.3
 Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 2/72 (2%)

Query: 114  RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173
            R + + K  +  LG+++   ++  + +++  I  G A  +   + +GD ILS+N      
Sbjct: 1007 RTINIAKGNSS-LGMTVSANKDG-LGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064

Query: 174  ATHDQAVQALKR 185
             T+ QA   L+R
Sbjct: 1065 VTNAQARAMLRR 1076


>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
           sapiens]
          Length = 907

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 43/97 (44%), Positives = 58/97 (59%), Gaps = 5/97 (5%)

Query: 99  PPRGPA--GEAGASP-PVRRVRVVKQEAG-GLGISIKGGRENRMPILISKIFPGLAADQS 154
           P R PA  G   A P  VR V + + +A  GLG SI+GG E+ + I +S + PG  A++ 
Sbjct: 121 PYRQPAWGGPDSAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKE 180

Query: 155 RALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVL 191
             LR+GD IL VN   L + TH +AV+ALK + K VL
Sbjct: 181 -GLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVL 216



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 39/118 (33%), Positives = 63/118 (53%), Gaps = 13/118 (11%)

Query: 89  RGLGPPSPPAPPRGPA-----GEAGASPPV------RRVRVVKQEAGGLGISIKGGRENR 137
           R + PPS    P G A     G+  ++  +      ++V +V  +   LG++I+GG E  
Sbjct: 242 RSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGGAEYG 301

Query: 138 MPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVK 195
           + I I+ + PG  A+ S  L++GD IL VNG       HD+AV+ LK + + ++L VK
Sbjct: 302 LGIYITGVDPGSEAEGS-GLKVGDQILEVNGRSFLNILHDEAVRLLK-SSRHLILTVK 357



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/146 (30%), Positives = 60/146 (41%), Gaps = 13/146 (8%)

Query: 44  SGESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGP 103
           SG++LS      A E E +           P  G    S     S+ L  P    P  G 
Sbjct: 756 SGQTLSEDSGVDAGEAEASA----------PGRGRQSVSTKSRSSKEL--PRNERPTDGA 803

Query: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPI-LISKIFPGLAADQSRALRLGDA 162
               G   P   +  VK+ A  LGI+I+GG   R P+  I  I  G +A     L++G  
Sbjct: 804 NKPPGLLEPTSTLVRVKKSAATLGIAIEGGANTRQPLPRIVTIQRGGSAHNCGQLKVGHV 863

Query: 163 ILSVNGTDLRQATHDQAVQALKRAGK 188
           IL VNG  LR   H +A + +  A K
Sbjct: 864 ILEVNGLTLRGKEHREAARIIAEAFK 889


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
           sapiens]
          Length = 926

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 6/105 (5%)

Query: 97  PAPPRGPAGEAGASPP-VRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQS- 154
           P+ P  P    G     +  +R+   E G  G ++KGG + +MP+++S++ PG  AD   
Sbjct: 498 PSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCV 557

Query: 155 RALRLGDAILSVNGTDLRQATHDQAVQALK----RAGKEVLLEVK 195
             L  GD ++ +NG D+ + THDQ V  +K    R   E++L V+
Sbjct: 558 PRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVR 602


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 15/111 (13%)

Query: 100  PRGPAGEAGASP------PVRRVRVVKQEAGGLGISIKGGR---------ENRMPILISK 144
            P    GE   +P      P R V + ++    LGISI GG+         E    I I +
Sbjct: 1047 PEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQ 1106

Query: 145  IFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVK 195
            +     A ++ AL+ GD IL V+G DL+ A+H +AV+A+K AG  V+  V+
Sbjct: 1107 VLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 29/77 (37%), Positives = 49/77 (63%), Gaps = 1/77 (1%)

Query: 119  VKQEAGGLGISIKGGRENRM-PILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHD 177
            + +   GLG+SI GG++  +  I+I +++   AA +   L  GD IL VNG DLR ++H+
Sbjct: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499

Query: 178  QAVQALKRAGKEVLLEV 194
            +A+ AL++  ++V L V
Sbjct: 1500 EAITALRQTPQKVRLVV 1516



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 42/116 (36%), Positives = 54/116 (46%), Gaps = 14/116 (12%)

Query: 116  VRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 175
            V + K+   GLG+SI G R N   + IS I  G AAD    L  GD ILSVNG D+R A+
Sbjct: 1534 VDLQKKAGRGLGLSIVGKR-NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNAS 1592

Query: 176  HDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDS 231
             +     LK A   V LE+  +R  +             W  A   S +  GS+ S
Sbjct: 1593 QETVATILKCAQGLVQLEIGRLRAGS-------------WTSARTTSQNSQGSQQS 1635



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 39/139 (28%), Positives = 64/139 (46%), Gaps = 18/139 (12%)

Query: 107  AGASPPVRRVRVVKQEAGGLGISIKGGRENRM---PILISKIFPGLAADQSRALRLGDAI 163
            +G     R V + ++ +  LGISI GGR + +   P+ I+ I     A +++ L++GD I
Sbjct: 1668 SGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRI 1727

Query: 164  LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSP 223
            +S+NG  L   +H   V  LK A   ++L+V               V+D      A Q  
Sbjct: 1728 VSINGQPLDGLSHADVVNLLKNAYGRIILQV---------------VADTNISAIAAQLE 1772

Query: 224  SFSGSEDSGSPKHQNSTKD 242
            + S     GSP  ++  +D
Sbjct: 1773 NMSTGYHLGSPTAEHHPED 1791



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 25/73 (34%), Positives = 40/73 (54%), Gaps = 2/73 (2%)

Query: 122 EAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQ 181
           +  GLG  I GG+ +   +++  I PG  AD+   L+ GD IL + GT+++  T +Q  Q
Sbjct: 254 DGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311

Query: 182 ALKRAGKEVLLEV 194
            L+  G  V + V
Sbjct: 312 VLRNCGNSVRMLV 324



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 24/161 (14%)

Query: 119  VKQEAGGLGISIKGGRE-NRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHD 177
            ++++  GLG+S+ G ++ +RM I +  I P   A     +R+GD +L +N   L   +H 
Sbjct: 1242 LEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301

Query: 178  QAVQALKRAGKEVLLEVKFIRE--------VTPY---IKKPSLVSDLPWEGAAPQSPSFS 226
             A   +K A  +V  ++ FIR         VTP+      PS + D    G  P S    
Sbjct: 1302 NASAIIKTAPSKV--KLVFIRNEDAVNQMAVTPFPVPSSSPSSIED--QSGTEPISSEED 1357

Query: 227  GSEDSG--------SPKHQNSTKDRKIIPLKMCFAARNLSM 259
            GS + G        S K   S   ++  P K+ F+++ + +
Sbjct: 1358 GSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPL 1398



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 4/77 (5%)

Query: 113 VRRVRVVKQEAGGLGISIKGGREN---RMPILISKIFPGLAADQSRALRLGDAILSVNGT 169
           +  + + +   GGLG S+   R     ++ I +  + PG  AD+ + L+  D IL++N T
Sbjct: 132 IEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHT 191

Query: 170 DLRQ-ATHDQAVQALKR 185
            L Q  +H QA+  L++
Sbjct: 192 PLDQNISHQQAIALLQQ 208



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 30/113 (26%), Positives = 53/113 (46%), Gaps = 14/113 (12%)

Query: 93  PPSPPAPP--------RGPAGEAGASPPVRRVRVVKQEAGGLGISIKG-----GRENRMP 139
           PP+P A P        +GP  ++        V +V+++   LGI I G            
Sbjct: 336 PPAPAALPVALPTVASKGPGSDSSLFETYN-VELVRKDGQSLGIRIVGYVGTSHTGEASG 394

Query: 140 ILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLL 192
           I +  I PG AA  +  +++ D I++V+G +++   +   V+ L+ AG+ V L
Sbjct: 395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447



 Score = 32.7 bits (73), Expect = 0.86
 Identities = 27/79 (34%), Positives = 41/79 (51%), Gaps = 5/79 (6%)

Query: 110 SPPVRRVRVVKQEAGGLGISIKGGRE----NRMPILISKIFPGLAADQSRALRLGDAILS 165
           SP V+ V +VK +  GLG SI   ++     R  I+I  +     A++S  L  GD ++S
Sbjct: 681 SPEVKIVELVK-DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739

Query: 166 VNGTDLRQATHDQAVQALK 184
           VN   L   +  +AV+ LK
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 38/105 (36%), Positives = 57/105 (54%), Gaps = 12/105 (11%)

Query: 98  APPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGR--------ENRMPILISKIFPGL 149
           A P G  GE   S  +    V+ +++G LG +I GGR         +   I +SKI    
Sbjct: 235 AAPPGGKGEETKSLTL----VLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSG 290

Query: 150 AADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEV 194
            A +   L++ D I+ VNG DL +ATHDQAV+A K A + ++++V
Sbjct: 291 PAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQV 335



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 20/67 (29%), Positives = 36/67 (53%), Gaps = 2/67 (2%)

Query: 117 RVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATH 176
           R+  Q+  GL +  +   E+ + I IS+I P   A +   +R GD I+ +NG +++    
Sbjct: 424 RMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQ--NR 481

Query: 177 DQAVQAL 183
           ++AV  L
Sbjct: 482 EEAVALL 488


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/105 (37%), Positives = 53/105 (50%), Gaps = 10/105 (9%)

Query: 87   PSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMP---ILIS 143
            P +G G   PP+PP   AGE      +  V +VK++ G LG S+ GG    +P   I + 
Sbjct: 906  PLKGAGSSCPPSPPEISAGE------IYFVELVKED-GTLGFSVTGGINTSVPYGGIYVK 958

Query: 144  KIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGK 188
             I PG  A +   +  GD +L V+G  L   TH QAVQ L   G+
Sbjct: 959  SIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ 1003



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 6/80 (7%)

Query: 119  VKQEAGGLGISIKGGRENRMPIL------ISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
            +K+ A GLG S     +     L      I ++FPG  A+++ A+  GD IL+VNG    
Sbjct: 1060 LKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTE 1119

Query: 173  QATHDQAVQALKRAGKEVLL 192
                 + +  L+ A +EV L
Sbjct: 1120 GLIFQEVLHLLRGAPQEVTL 1139


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 39/105 (37%), Positives = 53/105 (50%), Gaps = 10/105 (9%)

Query: 87   PSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMP---ILIS 143
            P +G G   PP+PP   AGE      +  V +VK++ G LG S+ GG    +P   I + 
Sbjct: 928  PLKGAGSSCPPSPPEISAGE------IYFVELVKED-GTLGFSVTGGINTSVPYGGIYVK 980

Query: 144  KIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGK 188
             I PG  A +   +  GD +L V+G  L   TH QAVQ L   G+
Sbjct: 981  SIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ 1025



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 6/80 (7%)

Query: 119  VKQEAGGLGISIKGGRENRMPIL------ISKIFPGLAADQSRALRLGDAILSVNGTDLR 172
            +K+ A GLG S     +     L      I ++FPG  A+++ A+  GD IL+VNG    
Sbjct: 1082 LKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTE 1141

Query: 173  QATHDQAVQALKRAGKEVLL 192
                 + +  L+ A +EV L
Sbjct: 1142 GLIFQEVLHLLRGAPQEVTL 1161


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,141,345
Number of Sequences: 37866
Number of extensions: 1160849
Number of successful extensions: 14134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 491
Number of HSP's that attempted gapping in prelim test: 10376
Number of HSP's gapped (non-prelim): 3613
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.