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Search of human proteins with 56606114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56606114 trichohyalin-like 1 [Homo sapiens]
(904 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56606114 trichohyalin-like 1 [Homo sapiens] 1808 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 102 1e-21
gi|148746195 trichohyalin [Homo sapiens] 96 2e-19
gi|60097902 filaggrin [Homo sapiens] 91 6e-18
gi|171916097 repetin [Homo sapiens] 86 2e-16
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 85 3e-16
gi|7706635 cornulin [Homo sapiens] 82 2e-15
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 73 1e-12
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 69 2e-11
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 67 6e-11
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 67 6e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 67 6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 67 6e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 66 2e-10
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 64 8e-10
gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 63 1e-09
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 62 2e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 62 2e-09
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 62 3e-09
gi|57864582 hornerin [Homo sapiens] 59 2e-08
gi|62244004 modulator of estrogen induced transcription isoform ... 59 2e-08
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 59 3e-08
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 58 5e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 6e-08
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 6e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 6e-08
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 57 6e-08
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 57 6e-08
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 57 1e-07
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 56 1e-07
>gi|56606114 trichohyalin-like 1 [Homo sapiens]
Length = 904
Score = 1808 bits (4684), Expect = 0.0
Identities = 904/904 (100%), Positives = 904/904 (100%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLL 60
MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLL
Sbjct: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLL 60
Query: 61 NIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQ 120
NIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQ
Sbjct: 61 NIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQ 120
Query: 121 WTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKN 180
WTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKN
Sbjct: 121 WTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKN 180
Query: 181 KHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAR 240
KHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAR
Sbjct: 181 KHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAR 240
Query: 241 EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPS 300
EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPS
Sbjct: 241 EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPS 300
Query: 301 SQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS 360
SQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS
Sbjct: 301 SQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS 360
Query: 361 ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ
Sbjct: 361 ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
Query: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF
Sbjct: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
Query: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT 540
VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT
Sbjct: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT 540
Query: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP 600
QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP
Sbjct: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP 600
Query: 601 GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA 660
GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA
Sbjct: 601 GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA 660
Query: 661 GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL 720
GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL
Sbjct: 661 GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL 720
Query: 721 LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK 780
LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK
Sbjct: 721 LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK 780
Query: 781 QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLT 840
QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLT
Sbjct: 781 QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLT 840
Query: 841 SEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREAS 900
SEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREAS
Sbjct: 841 SEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREAS 900
Query: 901 TTKQ 904
TTKQ
Sbjct: 901 TTKQ 904
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 102 bits (255), Expect = 1e-21
Identities = 139/614 (22%), Positives = 230/614 (37%), Gaps = 76/614 (12%)
Query: 196 IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQ- 254
I + NE LK + P+ KK + E QD +++ D E+ + +Q
Sbjct: 505 IMSLNSNEKSLKLS-PVQKQKKQQTIGELT-QDTALTENDDSDEYEEMSEMKEGKACKQH 562
Query: 255 --EGNLATQSSPPKEATQRPCEDQEVRTEKE-----KHSNIQEPPLQREDEPSSQHADLP 307
+G TQ + EA E+ E+ EKE K + I+E ++ +E H
Sbjct: 563 VSQGIFMTQPATTIEAFSD--EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRK 620
Query: 308 EQAAARSPSQTQKSTDSKDVCRMFDTQEPGKD-------------ADQTPAKTKNLGEPE 354
E+ S T K+ S+ + E G + A+ + + GE +
Sbjct: 621 EKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGE-K 679
Query: 355 DYGRTSETQ----EKECETKDLPVQYGSRNGSETSDM---------RDERKERRGPEAHG 401
D GR + EKE K+ ++ R+G E R++ E G E HG
Sbjct: 680 DKGRGEMERPGEGEKELAEKE---EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHG 736
Query: 402 TAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSET----QYLSSEGGDQTHP 457
++E DR+ ++G+ +E++G + ++ E+ E + E GDQ
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG 796
Query: 458 ELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVT 517
E E T GEE E E K E G E + E++ GE
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE-EEEGEGE----- 850
Query: 518 KTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQG 577
+ + EE+G +GE E EG E EEG E E +G+ + +G
Sbjct: 851 EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEE--GEGEGEEEG 908
Query: 578 DQHGESVQG-GHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLT---EDQEQPARGEH 633
+ GE +G G + +G E+ E GE+ + E++E GE
Sbjct: 909 EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968
Query: 634 KNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKG 693
+ +G G +G G E G E +E +E + E E G G+G
Sbjct: 969 EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG---------------EGEG 1013
Query: 694 DSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQE 753
+ E +V+G EE E + E + + + +E EEE+E +
Sbjct: 1014 EEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE---EEEEEEGKYQ 1070
Query: 754 LAGEGGDQKSPAKK 767
GE +++ ++
Sbjct: 1071 ETGEEENERQDGEE 1084
Score = 73.2 bits (178), Expect = 1e-12
Identities = 110/519 (21%), Positives = 201/519 (38%), Gaps = 60/519 (11%)
Query: 162 EAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSP 221
++K + + E N+ K G ++ E+ D T ++ ++ K + + P
Sbjct: 595 DSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT---DKAEVSEGKAKSVGEAEDGP 651
Query: 222 TERKGQDKEISQEGDEPAREQSVSKIRDQFG----EQEGNLATQSSPPKEATQRPCEDQE 277
R E G E +++ K G E+ G + + +E +R E+QE
Sbjct: 652 EGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQE 711
Query: 278 VRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPG 337
+ ++ H +E + E+ +H + E+ R + ++ + +E G
Sbjct: 712 QKEREQGHQ--KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEG----------EGKEEG 759
Query: 338 KDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGP 397
+ + + K GE + R + ++ E E G ET +E++E G
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ-----GEGEEEETEGRGEEKEE--GG 812
Query: 398 EAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHP 457
E G G+ E + R E + ++G+ +E +G + ++ E E EG +
Sbjct: 813 EVEG--GEVEEGKGER----EEEEEEGEGEEEEGEGEEEEGEGEEE------EGEGKGEE 860
Query: 458 ELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVT 517
E E GE E +EG E E G E + E++ GE
Sbjct: 861 EGE----EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEG---E 913
Query: 518 KTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELP-VQGDSQSQ 576
+ + EE+G +GE + +EG E + EG E GE + + + +
Sbjct: 914 EEEGEGKGEEEGEEGEGE----GEEEEGEGEGEDG----EGEGEEEEGEWEGEEEEGEGE 965
Query: 577 GDQHGESV-QGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKN 635
G++ GE + G + + +G GE+ E GE+ E +E+ GE +
Sbjct: 966 GEEEGEGEGEEGEGEGEEEEGEG-EGEEEEGEEEGEEEGEGEEEGEGEGEEE-EEGEVEG 1023
Query: 636 QGPGTKGPGAAVEPNGHPEAQE---STAGDENRKSLEIE 671
+ G +G G E G E +E G+ENR++ E E
Sbjct: 1024 EVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEE 1062
Score = 67.8 bits (164), Expect = 4e-11
Identities = 92/449 (20%), Positives = 165/449 (36%), Gaps = 62/449 (13%)
Query: 170 GEASEHNDPKNKHLEGDEQSQEVAQDIQ--TTEDNEGQLKTNKPMAGSKKTSSPTERKGQ 227
GE E + + H + Q E + + E+ EG + + G K E +G+
Sbjct: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKE----EGEGE 762
Query: 228 DKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
+ E +E +E R++ +++ GE+EG+ Q +E T+ E++E E E
Sbjct: 763 EVEGEREKEEGERKKEERAGKEEKGEEEGD---QGEGEEEETEGRGEEKEEGGEVEG-GE 818
Query: 288 IQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKT 347
++E +RE+E + E + + +E G+ + +
Sbjct: 819 VEEGKGEREEEEEEGEGEEEEGEGEEEEGEGE--------------EEEGEGKGEEEGEE 864
Query: 348 KNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKE 407
GE E+ G E + +E E G G E + E +E G G+ E
Sbjct: 865 ---GEGEEEGEEGEGEGEEEE--------GEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
Query: 408 RDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGE 467
+ E + +G+ +E +G + +D E E E G+ E EG E
Sbjct: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE-----EEEGEWEGEEEEGEGEGEE 968
Query: 468 EAE-HTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEE 526
E E +EG E E G E ++ E + GE EE
Sbjct: 969 EGEGEGEEGEGEG----------EEEEGEGEGEEEEGEEEGEEEGEG-----------EE 1007
Query: 527 EDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQG 586
E +GE+ E + + E EEG E E +G+ + + E +G
Sbjct: 1008 EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEG 1067
Query: 587 GHNNNPDTQRQGTPGEKNRALEAVVPAVR 615
+ + + + GE+ + + + +V+
Sbjct: 1068 KYQETGEEENERQDGEEYKKVSKIKGSVK 1096
Score = 65.5 bits (158), Expect = 2e-10
Identities = 121/600 (20%), Positives = 221/600 (36%), Gaps = 71/600 (11%)
Query: 192 VAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQF 251
VA++I+ E N+ L + S TS ++ + + E R +R
Sbjct: 371 VAKEIEFDEINDTCLSVATFLPYSSLTSGNVLQRTLSARMRRR--ERERSPDSFSMRRTL 428
Query: 252 GEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAA 311
EG L + + C ++ ++ S + E L + +EP ++ ++A
Sbjct: 429 PPIEGTLGLSACFLPNSVFPRCSERNLQ-----ESVLSEQDLMQPEEPDYLLDEMTKEAE 483
Query: 312 ARSPSQTQKSTDSKDVCRMFDTQEPGKDAD-------QTPAKTKNLGE------------ 352
+ S + ++ D+ M + Q K + +GE
Sbjct: 484 IDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDD 543
Query: 353 PEDYGRTSETQE-KECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRK 411
++Y SE +E K C+ + ++ + DE E PE +KE
Sbjct: 544 SDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEI--PE------EKEGAED 595
Query: 412 TRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEH 471
++ +E Q + + ++ K+ +T+ LS + D+ EG A S EAE
Sbjct: 596 SKGNGIEEQEVEANEENVKVHGGRKE-----KTEILSDDLTDKAEVS-EGKAKSVGEAED 649
Query: 472 TKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQ 531
EG + ++ A RE+ + + + GE R + + E+E+ +
Sbjct: 650 GPEGRGDGTCEEGSSGAEHWQDEEREKGE-----KDKGRGEMERPGEGEKELAEKEEWKK 704
Query: 532 GEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNN 591
+ E + ++G + N E G GE +GD + + ++ GE + G
Sbjct: 705 RDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGE-EEEGDREEEEEKEGEGKEEGEGEE 763
Query: 592 PDTQRQGTPGEKNRALEAVVPAVRGE---DVQLTEDQEQPARGEHKNQGPGTKGPGAAVE 648
+ +R+ GE+ + E +GE D E++E RGE K +G +G G E
Sbjct: 764 VEGEREKEEGERKKE-ERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG-GEVEE 821
Query: 649 PNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKE 708
G E +E E + E G +E+ + GKG+ E E
Sbjct: 822 GKGEREEEEEEGEGEEEEGEGEEEEGEGEEE--------EGEGKGEEEGE-----EGEGE 868
Query: 709 EKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKE 768
E+G E + +E+ + E E E E +E GEG +++ K E
Sbjct: 869 EEGEEGEGEG------EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 95.5 bits (236), Expect = 2e-19
Identities = 185/937 (19%), Positives = 342/937 (36%), Gaps = 140/937 (14%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFF-QPCVLHAVEKNSNL 59
M LLR++ + E F++Y S D +GA LT ++LK L++ EFG +P V+ L
Sbjct: 1 MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAVLRRPHDPKTVDLILEL 60
Query: 60 LNIDSNGIISFDEFVLAIFNLLNLCY----------------LDIKSLLSSELRQVTKPE 103
L++DSNG + F+EF+L IF + CY D K L + RQ + +
Sbjct: 61 LDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQ--EED 118
Query: 104 KEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREA 163
+ + + D Q GQ QE+ + S Q E+ + + WR+
Sbjct: 119 QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDE-ELWRQR 177
Query: 164 ----------------------KTHNFPGEAS----EHNDPKNKHLEGDEQSQEVAQDIQ 197
+T FP E E + + K E +Q + QD
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 198 TTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDE--PAREQSVSKIRDQFGEQE 255
E+ E + + + + ++ E + +E+ +E ++ Q + + R + +Q+
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 256 GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQ----------------EPPLQREDEP 299
L + ++ + E QE R E+++ Q E L+RE E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 300 SSQHADL-PEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKD----ADQTPAKTKNLGEPE 354
+ L EQ R Q ++ + ++ Q+ ++ +Q + + L +
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 355 DYGRTS----ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQK---- 406
R E +E+ E K + R E + RD K E H +K
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477
Query: 407 ---ERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTA 463
E +R+ R L LE + + + QE + ++ E+ E + E ++ L
Sbjct: 478 RDQEEERRERWLKLE-EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 464 VSGEEAEHTKEGTAEAFVNSK-NAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQ 522
E E +E + + E+ L + + L+++ R+ + ++
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 523 PVEEE-DGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHG 581
+E+ + E E + E P ++ S E E Q + Q ++
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 582 ESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGP--- 638
+ ++ QR E+ R + +L E++++ AR K++ P
Sbjct: 657 QRLKREEEEERLEQRLKREHEEER-----------REQELAEEEQEQARERIKSRIPKWQ 705
Query: 639 ---GTKGPGAAVEPNGHPEAQES----TAGDENRKSLEIEITGALDE------------- 678
++ + P QE +E R+ E E+ +E
Sbjct: 706 WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 679 DFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQ--- 735
DFT Q + +G R + +E + RA E Q L E+ + +
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR 825
Query: 736 --------LETKEPVTSEEEDESPQELA-GEGGDQKSPAKKEHNSSVPWS-SLEKQMQRD 785
LE +E + E + QE G DQ+ +E W LE++ +R
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR- 884
Query: 786 QEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQK 822
R +Y+ P LQE++ ++ + QEE ++
Sbjct: 885 ------RRHTLYAKPA---LQEQLRKEQQLLQEEEEE 912
Score = 63.2 bits (152), Expect = 1e-09
Identities = 145/742 (19%), Positives = 270/742 (36%), Gaps = 112/742 (15%)
Query: 146 PEESGAVGNNRV-------DPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQT 198
PE+ AV +N+V + +R+ + S+ + +HL G++Q ++ Q+ +
Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD---LQHLLGEQQERDREQERRR 1285
Query: 199 TEDNEGQLKTNKPMAGSK-KTSSPTERKGQDKE--ISQEGDEPAREQSVSKIRDQFGEQE 255
+ + + + + K + +RK Q+++ + +E +E R Q + +F E+E
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR---KFREEE 1342
Query: 256 GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHAD---LPEQAAA 312
L + P +R D++ R E+ +H L+ E Q + L E+
Sbjct: 1343 QLLQEREEQPLRRQER---DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 313 RSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDL 372
R + Q+ +D R F +E + K + E E R E + K E +
Sbjct: 1400 RCQEREQQLRQDRD--RKFREEEQQLSRQERDRKFR---EEEQQVRRQERERKFLEEEQQ 1454
Query: 373 PVQYGSRNGSETSDMRDERKE---------RRGPEAHGTAGQKERDRKTRPLVLETQTQD 423
Q R E + ER+E R+ E ++ERDRK R L +Q +
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE 1514
Query: 424 GKY-QELQGLSKSKDAEK--GSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
K+ +E Q L + + K E Q E G Q + + E+ +E
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE------ 1568
Query: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVG--ENTRVTKTHDQPVEEEDGYQG--EDPE 536
E+ L +ER + LE+Q V E R +Q + ++G Q ++ +
Sbjct: 1569 ---------EQQLSRQERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 537 SPFTQSDE----------GSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQG 586
F + ++ E EE + E ++ D + + + +Q
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 587 GHNNN----------PDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
G + ++Q E+ R +R ++++ +E+ R E + +
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Query: 637 GPGTKGPGAAV--EPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGD 694
+ + E PE +E + R E E QL + K
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798
Query: 695 SRNELKVQG------PSSKEEKGRATEAQNTLLES-----LDEDNSASLKIQLETKEPVT 743
+L+ + P ++ K R E Q L E + D + Q T+E
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 744 SEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGA-------- 795
EE++ +E +++ ++EH + E+Q R + G
Sbjct: 1859 REEQELWQEEEQKRRQERERKLREEH---IRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Query: 796 ---------VYSSPLYQYLQEK 808
V SSPLY+Y+QE+
Sbjct: 1916 GTHQFASVPVRSSPLYEYIQEQ 1937
Score = 55.1 bits (131), Expect = 3e-07
Identities = 96/512 (18%), Positives = 186/512 (36%), Gaps = 42/512 (8%)
Query: 147 EESGAVGNNRVD---PWREAKTHNFPGEASEHNDPKNKHLEGDE-----QSQEVAQDIQT 198
EE G R+ P RE + E + + + E ++ Q +E +++Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 199 TEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNL 258
E+ E + + ++ E + + + Q D+ R Q + + +
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 259 ATQSSPPKEATQRPCEDQEV-RTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQ 317
A Q KE E++E+ R E+EK ++ RE+E Q E+ R +
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE----EEQLLREERE 949
Query: 318 TQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYG 377
++ + + R KD + + LGE + R E ++K E ++L +
Sbjct: 950 KRRRQERERQYR--------KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE-- 999
Query: 378 SRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKD 437
E +R+ER++RR E +K+ ++ +L + + + QE + + ++
Sbjct: 1000 -----EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054
Query: 438 AEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARE 497
+ E Q L E + ELE EE + +E + ER E
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114
Query: 498 RTQD------LAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQ-------SDE 544
Q EK+ E R + ++ +EE+ E+PE Q +E
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 545 GSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKN 604
+ L EE + E + + + Q + + + + D + Q P ++N
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR-DEDQRSDLKWQWEPEKEN 1233
Query: 605 RALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
+ V E+ Q + ++ R Q
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Score = 52.0 bits (123), Expect = 2e-06
Identities = 121/613 (19%), Positives = 230/613 (37%), Gaps = 60/613 (9%)
Query: 183 LEGDEQSQEVAQDI--QTTEDNEGQLKTNKPMAG-SKKTSSPTERKGQDKEISQEGDEPA 239
L+ +EQ + Q + + E E +LK + ++ E + +++E+++E E A
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 240 REQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEP 299
RE+ S+I + E + S + R E Q R E+E+ +E LQ ++E
Sbjct: 694 RERIKSRIPKWQWQLESEADARQS-KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE- 751
Query: 300 SSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRT 359
R+ Q Q+ +D + +E + Q + L E +
Sbjct: 752 ------------ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 360 SETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLET 419
+E +++ E + LP E + R++RR E ++E + R +
Sbjct: 800 AEERQQR-EQRFLP---------EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 420 QTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEA 479
Q ++ QE Q +S++ + + ++ E + L E+ ++ E
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE- 908
Query: 480 FVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPF 539
E L ER EK+ E R + +Q +EE+ E+ E
Sbjct: 909 ---------EEEELQREER-------EKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 540 TQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGT 599
Q E L +E GE P + Q + ++ E + + Q
Sbjct: 953 RQERERQYRKDKKLQQKE---EQLLGEEPEKRRRQEREKKYREEEE---LQQEEEQLLRE 1006
Query: 600 PGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQEST 659
EK R E + +++Q +++EQ R E + + + E E +E
Sbjct: 1007 EREKRRRQEWERQYRKKDELQ--QEEEQLLREEREKRRLQERERQYREEEELQQE-EEQL 1063
Query: 660 AGD--ENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQ 717
G+ E R+ E+E +E+ Q QL + + + + +EE+ E +
Sbjct: 1064 LGEERETRRRQELERQYRKEEEL--QQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 718 NTLLESLDEDNSASLKIQLETKEPVTSEEED---ESPQELAGEGGDQKSPAKKEHNSSVP 774
L E ++ L+ Q +E V EEE E P++ + +++ ++E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 775 WSSLEKQMQRDQE 787
E+Q +R QE
Sbjct: 1182 QLLREEQEKRRQE 1194
Score = 45.8 bits (107), Expect = 2e-04
Identities = 121/671 (18%), Positives = 238/671 (35%), Gaps = 51/671 (7%)
Query: 174 EHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQ 233
E + + + L+ E+ + + Q +++ E QL+ + ++ ++ ++K + Q
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRS----EQQLRREQ-----EERREQLLKREEEKRLEQ 560
Query: 234 EGDEPAREQSVSKIRDQFGEQEGNLATQS---SPPKEATQRPCEDQEVRTEKEKHSNIQE 290
E E ++ + RDQ ++E Q + QR ++ R E+E+ +E
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER---RE 617
Query: 291 PPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNL 350
L+RE+ + L + Q Q + ++ +E ++ + K ++
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 351 GEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDR 410
E + E QE+ E + +D R + R + G ++E++
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 411 KTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAE 470
K R E Q Q+ + Q + ++ + Q+ + E ++ L E+ E
Sbjct: 738 KRRRRESELQWQEEERAHRQ--QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 471 HTKEGTAEAFVNSKNAPAAE----RTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEE 526
+ P E R RER ++L LE++ E + + Q EE
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE---EQLQRRERAQQLQEE 852
Query: 527 EDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQ----HGE 582
EDG Q ED E +Q + L E P + + Q E
Sbjct: 853 EDGLQ-EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 583 SVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKG 642
+Q Q Q + L+ + E+ L E++E+ R E + Q K
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQ------QEEEQLLREEREKRRRQERERQYRKDKK 965
Query: 643 PGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQ 702
E E ++ + +K E E +E + + + + R K
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE-RQYRKKD 1024
Query: 703 GPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQ- 761
+EE+ E + L+ + ++Q E ++ + E E QEL + +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 762 -----------KSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKIL 810
+ P K+ E+++Q+++E E Q L+ +
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE---REKRRRQELERQYR 1141
Query: 811 QQTNVTQEEHQ 821
++ V QEE Q
Sbjct: 1142 EEEEVQQEEEQ 1152
Score = 32.7 bits (73), Expect = 1.6
Identities = 90/475 (18%), Positives = 167/475 (35%), Gaps = 66/475 (13%)
Query: 361 ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
E + C+ K+ +Q E R E ++R+ E G +++R + R L E +
Sbjct: 97 EEKRARCDGKESLLQ---DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA-EGE 152
Query: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
Q K + L+ +D ++ E + Q E E E+ + K E F
Sbjct: 153 EQSEKQERLE----QRDRQRRDEELWRQR----QEWQEREERRAEEEQLQSCKGHETEEF 204
Query: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT 540
+ + R ++L L ++ E + Q E +D E+ E +
Sbjct: 205 PDEEQL-----------RRRELLELRRKGREEKQQ------QRRERQDRVFQEEEEKEWR 247
Query: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP 600
+ + + L EE E E E ++ +RQ
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQE-------------EEEQLRKLERQELRRERQEEE 294
Query: 601 GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA 660
++ R + E+ + + +E+ + E + Q + E E Q
Sbjct: 295 QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354
Query: 661 GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL 720
+E R+ E ++ +E+ +Q QL + R E ++ + E+ E Q
Sbjct: 355 QEEERR--EQQLRREQEEERREQ----QLRREQQLRREQQL-----RREQQLRREQQLRR 403
Query: 721 LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK 780
+ L + + QL ++ + E+E+E E E ++ K+E W E+
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEER-HEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 781 ------------QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQ 823
Q++RDQE ER + QE+ QQ QEE ++Q
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 90.5 bits (223), Expect = 6e-18
Identities = 147/689 (21%), Positives = 248/689 (35%), Gaps = 70/689 (10%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQ-PCVLHAVEKNSNL 59
M LL N+ +I F +Y+ +D N TL+ +ELK+L++ EF + P V+ +
Sbjct: 1 MSTLLENIFAIINLFKQYSKKDKNTDTLSKKELKELLEKEFRQILKNPDDPDMVDVFMDH 60
Query: 60 LNIDSNGIISFDEFVLAIFNLLNLCYLDIK--SLLSSELRQVTKPEKEKLDDVDVQATTG 117
L+ID N I F EF+L +F L Y + +L S + +K +D + Q
Sbjct: 61 LDIDHNKKIDFTEFLLMVFKLAQAYYESTRKENLPISGHKHRKHSHHDKHED-NKQEENK 119
Query: 118 DGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAK----THNFPGEAS 173
+ + + + R G + S P E+G + +E K TH
Sbjct: 120 ENRKRPSSLERRNNRKGNKGRSKS----PRETGGKRHESSSEKKERKGYSPTHREEEYGK 175
Query: 174 EHNDPKNKHLEGDEQS------QEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQ 227
H++ K E + + +++ ++ EDNE + + + T T++ Q
Sbjct: 176 NHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNE------EGVYDYENTGRMTQKWIQ 229
Query: 228 DKEIS-------QEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRT 280
I+ + D +KI ++ +G ++Q + + QE RT
Sbjct: 230 SGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRT 289
Query: 281 EKEKHSNIQEPPLQREDEPSSQHADLPEQAAARS--PSQTQKSTDSKDVCRMFDTQEP-- 336
K + S + + R+ E S+ ++ +A+R+ S ++S D R D
Sbjct: 290 RKRRGSRVSQ---DRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSRHPRSHDEDRASH 346
Query: 337 GKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRG 396
G AD + E G+T+ + E + + P G R+GS D R
Sbjct: 347 GHSADSSRQSGTRHAETSSRGQTASSHE---QARSSP---GERHGSGHQQSAD--SSRHS 398
Query: 397 PEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTH 456
G A DR R S S+ + S+TQ +S G
Sbjct: 399 ATGRGQASSAVSDRGHRG------------SSGSQASDSEGHSENSDTQSVSGHGKAGLR 446
Query: 457 PELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRV 516
+ + G E + + + S + E+ A RT + S E R
Sbjct: 447 QQSHQESTRGRSGERSGRSGSSLYQVSTH----EQPDSAHGRTGTSTGGRQGSHHEQARD 502
Query: 517 TKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQ 576
+ H E +D +G S + ++ N G+S S QG S +
Sbjct: 503 SSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVN----RSGHSGSHHSHTTSQGRSDAS 558
Query: 577 GDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
Q G N + GT +R EA A Q+ + Q R +NQ
Sbjct: 559 HGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPR-TSRNQ 617
Query: 637 GPGTKGPGAAVEPNGHPEAQESTAGDENR 665
G + GH E E +G +R
Sbjct: 618 GSSVSQDS---DSQGHSEDSERWSGSASR 643
Score = 66.2 bits (160), Expect = 1e-10
Identities = 133/679 (19%), Positives = 239/679 (35%), Gaps = 114/679 (16%)
Query: 136 SGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQD 195
S AS + E+SG + V EA TH + S H+ EG +S+
Sbjct: 3158 SRSASRTTRNEEQSGDSSRHSVSRHHEASTH---ADISRHSQAVQGQSEGSRRSRRQGSS 3214
Query: 196 IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQE 255
+ D+EG + ++ +GS + +G +E S+ G R S D+ G
Sbjct: 3215 VSQDSDSEGHSEDSERWSGSASRN----HRGSVQEQSRHGSRHPR----SHHEDRAGH-- 3264
Query: 256 GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQR------EDEPSSQHADLPEQ 309
G+ A +S +++ R E H + P +R + SS+H+ +P
Sbjct: 3265 GHSADRS---RQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRG 3321
Query: 310 AAARSP-------SQTQKSTDSKDVCRMFDTQE--------PGKDADQTPAKTKNLGEPE 354
A+ + S +++DS+ DTQ P + + Q A+ ++ G
Sbjct: 3322 QASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSG 3381
Query: 355 DYG----RTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTA-GQKERD 409
G + S ++ E G R GS RD + E T G
Sbjct: 3382 RSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSS 3441
Query: 410 RKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEA 469
R+ R Q Y++ S + GS + +S+G G+ + +
Sbjct: 3442 RRGR--------QGSHYEQ----SVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQT 3489
Query: 470 ---EHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEE 526
E + +G+ ++ + A + + Q + + S + + V++ D
Sbjct: 3490 RNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHS 3549
Query: 527 EDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSE--TGELPVQGDSQSQGDQHGESV 584
ED + S ++ GS++ + S S E G S+ G H E+
Sbjct: 3550 EDSERWSGSAS---RNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENS 3606
Query: 585 QGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPG 644
GG + Q + + GE++ + Q + ++ G G
Sbjct: 3607 SGGQAASSHEQARSSAGERHGS------------------HHQQSADSSRHSGIGHGQAS 3648
Query: 645 AAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGP 704
+AV +GH + S A D G ++ T +S G ++ +G
Sbjct: 3649 SAVRDSGHRGSSGSQASDSE---------GHSEDSDTQSVSAHGQAGPHQQSHQESTRGR 3699
Query: 705 SSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAG--EGGDQK 762
S+ GR+ + + L + V++ E+ ES AG GG Q
Sbjct: 3700 SA----GRSGRSGSFLYQ-------------------VSTHEQSESAHGRAGPSTGGRQG 3736
Query: 763 SPAKKEHNSSVPWSSLEKQ 781
S ++ +SS +S E Q
Sbjct: 3737 SRHEQARDSSRHSASQEGQ 3755
Score = 65.9 bits (159), Expect = 2e-10
Identities = 113/601 (18%), Positives = 194/601 (32%), Gaps = 67/601 (11%)
Query: 109 DVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNR---VDPWREAKT 165
D +T+ +GQ T+ P S + + + SG G++ R +
Sbjct: 2448 DSSRHSTSQEGQDTIHGHPGSSSG---GRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDAS 2504
Query: 166 HNFPGEASEHNDPKNKHLEGD--EQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTE 223
H G S +N GD S + + D+ G + + + +TS
Sbjct: 2505 HGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWG 2564
Query: 224 RKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKE 283
SQ E + S S R+ G + L S P+ + Q +
Sbjct: 2565 SSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPR-SHQEDRAGHGHSADSS 2623
Query: 284 KHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQT 343
+ S + + +S H A R S Q+S DS ++ G Q
Sbjct: 2624 RQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS--------SRHSGIGHGQA 2675
Query: 344 PAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRG------- 396
+ ++ G G S+ + E ++D Q S +G S + ++ RG
Sbjct: 2676 SSAVRDSGHRGYSG--SQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSG 2733
Query: 397 ---------------PEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKG 441
+HG G R R Q ++++ Q S+ ++ G
Sbjct: 2734 HSGSFLYQVSTHEQSESSHGWTGPSTRGR-----------QGSRHEQAQDSSRHSASQDG 2782
Query: 442 SET---QYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARER 498
+T SS GG Q + SG H T++ ++ + R+ R
Sbjct: 2783 QDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTR 2842
Query: 499 TQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT--QSDEGSSETPNSLASE 556
++ + + G TH QG+ S + Q S ++ + SE
Sbjct: 2843 NEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSE 2902
Query: 557 EGNSSSETGELPVQGDSQSQ---GDQHGESVQ---GGHNNNPDTQRQG----TPGEKNRA 606
+ S + G +Q Q G +H S Q GH ++ D+ RQ T
Sbjct: 2903 DSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQ 2962
Query: 607 LEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRK 666
+ R + Q + ++ G G +AV +GH S A D
Sbjct: 2963 AASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGH 3022
Query: 667 S 667
S
Sbjct: 3023 S 3023
Score = 60.5 bits (145), Expect = 7e-09
Identities = 110/614 (17%), Positives = 207/614 (33%), Gaps = 80/614 (13%)
Query: 105 EKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAK 164
E+ D + + +GQ T+ P + S SG+ ++ R
Sbjct: 498 EQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDA 557
Query: 165 THNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTER 224
+H G S +N+ GD ++ + + + + G ++S P
Sbjct: 558 SHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADS---SRHSQVGQGQSSGPRTS 614
Query: 225 KGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRT---- 280
+ Q +SQ+ D + + A + S ++ ++ P E R
Sbjct: 615 RNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQS--RDGSRHPRSHHEDRAGHGH 672
Query: 281 --EKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQ-KSTDSKDVCRMFDTQEPG 337
+ + S + + +S H A R S+ Q +S DS ++ G
Sbjct: 673 SADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADS--------SRHSG 724
Query: 338 KDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPV-----QYGSRNGSETSDMRD--- 389
Q + ++ G G + E E D Q G S RD
Sbjct: 725 TGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSG 784
Query: 390 ERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQE-LQGLSKSKDAEKGSET---- 444
ER R G + + K+ + T + G + E + S+ ++ G +T
Sbjct: 785 ERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGH 844
Query: 445 QYLSSEGGDQTHPE--LEGTAVSGEEAEHT-KEGTAEAFVNSKNAPAAERTLGARERTQD 501
S G +H E ++ + SG HT +G ++A + +A RT E+++D
Sbjct: 845 PGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRD 904
Query: 502 --------------LAPLEK-----QSVGENTRVTKTHDQPVEEEDGYQGEDPESP---- 538
A + + Q E +R ++ V ++ +G +S
Sbjct: 905 GSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSG 964
Query: 539 -FTQSDEGSSETPNSLASEEGNSSSE--TGELPVQGDSQSQGDQHGESVQGGHNNNPDTQ 595
+++ GS++ + S S E G S+ G H E+ GG + Q
Sbjct: 965 SASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQ 1024
Query: 596 RQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEA 655
+ +PGE++ + + Q + ++ G + +AV +GH +
Sbjct: 1025 ARSSPGERHGS------------------RHQQSADSSRHSGIPRRQASSAVRDSGHWGS 1066
Query: 656 QESTAGDENRKSLE 669
S A D S E
Sbjct: 1067 SGSQASDSEGHSEE 1080
Score = 58.9 bits (141), Expect = 2e-08
Identities = 103/527 (19%), Positives = 180/527 (34%), Gaps = 104/527 (19%)
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQS-----QEVAQDIQTTEDNEGQLKTNKPMAGS 215
R+ H ++S H+ + H +S Q ++ T NE Q +GS
Sbjct: 2797 RQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGS 2856
Query: 216 K----KTSSPTERKGQDKEISQEGDEPAREQ--SVSKIRDQFGEQEGNLATQSSPPK--- 266
+ T + R Q + EG +R Q SVS+ D G E + S +
Sbjct: 2857 RHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHH 2916
Query: 267 --------EATQRPCEDQEVRT------EKEKHSNIQEPPLQREDEPSSQHADLPEQAAA 312
+ ++ P QE R + + S + + +S H A
Sbjct: 2917 GSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGE 2976
Query: 313 RSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDL 372
R S Q+S DS ++ G Q + ++ G G S+ + E ++D
Sbjct: 2977 RHGSHHQQSADS--------SRHSGIGHGQASSAVRDSGHRGYSG--SQASDNEGHSEDS 3026
Query: 373 PVQYGSRNGSETSDMRDERKERRG----------------------PEAHGTAGQKERDR 410
Q S +G S + ++ RG +HG G R R
Sbjct: 3027 DTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGR 3086
Query: 411 KTRPLVLETQTQDGKYQELQGLSKSKDAEKGSET---QYLSSEGGDQTHPELEGTAVSGE 467
Q ++++ Q S+ ++ G +T SS GG Q + SG
Sbjct: 3087 -----------QGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGH 3135
Query: 468 EAEH----TKEGTAEAFVNSKNAPAAERTLGARERTQDL--------------APLEK-- 507
H T +G ++A + +A RT E++ D A + +
Sbjct: 3136 SGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHS 3195
Query: 508 ---QSVGENTRVTKTHDQPVEEEDGYQGEDPESP-----FTQSDEGSSETPNSLASEEGN 559
Q E +R ++ V ++ +G +S +++ GS + + S
Sbjct: 3196 QAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPR 3255
Query: 560 SSSE--TGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKN 604
S E G S+ G +H E+ GG + Q + +PGE++
Sbjct: 3256 SHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERH 3302
Score = 53.1 bits (126), Expect = 1e-06
Identities = 127/658 (19%), Positives = 215/658 (32%), Gaps = 102/658 (15%)
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
R+ + G+ S H+ ++H E + ++ Q ++ +T++ S S
Sbjct: 1218 RQTRKDKQSGDGSRHSG--SRHHEAASWADS-SRHSQVGQEQSSGSRTSRHQGSSVSQDS 1274
Query: 221 PTERKGQDKE-----ISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCED 275
+ER D E S+ +REQS R QE + S +
Sbjct: 1275 DSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSR-----QS 1329
Query: 276 QEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQE 335
TE H Q P +H +Q+A S + R D+
Sbjct: 1330 GTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVR--DSGH 1387
Query: 336 PGKDADQTPAKTKNLGEPED--------YGRTSETQEKECETKDLPVQYGSRNGSETSDM 387
G Q T + G ED +G+ Q+ E+ Q G +G S +
Sbjct: 1388 RGSSGSQV---TNSEGHSEDSDTQSVSAHGQAGPHQQSHKESAR--GQSGESSGRSRSFL 1442
Query: 388 RDERKERRGPEAHG-----TAG-QKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKG 441
+ HG T G Q R + R + +QDG+ S+ +G
Sbjct: 1443 YQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQG 1502
Query: 442 SETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAA---ERTLGAR-- 496
S + G + T +A H + G A ++N + R G+R
Sbjct: 1503 SYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHH 1562
Query: 497 ERTQDLAPLEKQSVGEN----TRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNS 552
E + VG+ ++ ++ V ++ +G +S + E +S
Sbjct: 1563 EPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSE--RRSESASRNHYG 1620
Query: 553 LASEEG-----NSSSETGELPVQG----DSQSQGDQHGESVQGGHNNNPDTQRQGTPGEK 603
A E+ N S + G S+ G +H E+ GG + Q + +PGE+
Sbjct: 1621 SAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGER 1680
Query: 604 NRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDE 663
+ + + Q + + G G + + V +G+ + S A D
Sbjct: 1681 HGS------------------RHQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDS 1722
Query: 664 NRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLES 723
G +E T +S G ++ +G S E GR
Sbjct: 1723 E---------GHSEESDTQSVSAHGQAGPHQQSHQESTRGQSG-ERSGR----------- 1761
Query: 724 LDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQ 781
S S Q+ T E S P GG Q+S ++ +SS +S E Q
Sbjct: 1762 -----SGSFLYQVSTHEQSESAHGRTGP----STGGRQRSRHEQARDSSRHSASQEGQ 1810
Score = 51.2 bits (121), Expect = 4e-06
Identities = 129/730 (17%), Positives = 239/730 (32%), Gaps = 118/730 (16%)
Query: 105 EKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAK 164
E+ D + + +GQ T+ P + S SG+ ++ R
Sbjct: 1795 EQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDV 1854
Query: 165 THNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTER 224
+ G S +N+ GD ++ + + + + G ++S P
Sbjct: 1855 SRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADS---SRHSQVGQGQSSGPRTS 1911
Query: 225 KGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRT---- 280
+ Q +SQ+ D + + A + S ++ ++ P E R
Sbjct: 1912 RNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQS--RDGSRHPGSHHEDRAGHGH 1969
Query: 281 --EKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQ-KSTDSKDVCRMFDTQEPG 337
+ + S + + +S H A R S Q +S DS ++ G
Sbjct: 1970 SADSSRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADS--------SRHSG 2021
Query: 338 KDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGP 397
Q + ++ G G S+ + E ++D Q S G + ++ RG
Sbjct: 2022 IGHGQASSAVRDSGHRGYSG--SQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQ 2079
Query: 398 --EAHGTAGQKERDRKTRPLVLETQTQDGK---------YQELQGLSKSKDAEKGSET-- 444
E+ G +G T T Q Y + Q S+ +++G +T
Sbjct: 2080 SGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIR 2139
Query: 445 -QYLSSEGGDQTHPELEGTAVSGEEAEH----TKEGTAEAFVNSKNAPAAERTLGARERT 499
S GG Q + + SG H T +G ++A + +A R +E++
Sbjct: 2140 GHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQS 2199
Query: 500 QDLA-------------------PLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESP-- 538
D + L Q R ++ V ++ +G +S
Sbjct: 2200 GDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERR 2259
Query: 539 ---FTQSDEGSSETPNSLASEEGNSSSE--TGELPVQGDSQSQGDQHGESVQGGHNNNPD 593
+++ GS++ + S S E G S+ G H E+ GG +
Sbjct: 2260 SGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSH 2319
Query: 594 TQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHP 653
Q + + GE++ + Q + ++ G G +AV +GH
Sbjct: 2320 EQARSSAGERHGS------------------HHQQSADSSRHSGIGHGQASSAVRDSGHR 2361
Query: 654 EAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRA 713
+ S A D G ++ T +S G ++ +G S+ GR+
Sbjct: 2362 GSSGSQASDSE---------GHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSA----GRS 2408
Query: 714 TEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAG--EGGDQKSPAKKEHNS 771
+ + L + V++ E+ ES G GG Q S K+ +S
Sbjct: 2409 GRSGSFLYQ-------------------VSTHEQSESAHGRTGTSTGGRQGSHHKQARDS 2449
Query: 772 SVPWSSLEKQ 781
S +S E Q
Sbjct: 2450 SRHSTSQEGQ 2459
Score = 50.8 bits (120), Expect = 6e-06
Identities = 125/674 (18%), Positives = 224/674 (33%), Gaps = 105/674 (15%)
Query: 154 NNRVDPWREAKTHNFPGEASEH----NDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTN 209
++R R A+T + AS H + P +H G +QS + ++ T ++
Sbjct: 352 SSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSD 411
Query: 210 KPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEAT 269
+ GS G S+ E + QSVS G + L QS +E+T
Sbjct: 412 RGHRGSS---------GSQASDSEGHSENSDTQSVS------GHGKAGLRQQSH--QEST 454
Query: 270 QRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCR 329
+ ++ R+ + + ++P S H R S +++ DS R
Sbjct: 455 RGRSGERSGRSGSSLYQ------VSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSS---R 505
Query: 330 MFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRD 389
+QE P ++ GR E+ +R+G S
Sbjct: 506 HSASQEGQDTIRGHPGSSRG-------GRQGSHHEQSV----------NRSGHSGSHHSH 548
Query: 390 ERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSS 449
+ R +HG +G + R+TR E Q+ DG GS SS
Sbjct: 549 TTSQGRSDASHGQSGSRSASRQTRN---EEQSGDGT------------RHSGSRHHEASS 593
Query: 450 EGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSK-NAPAAERTLGARERTQDLAPLEKQ 508
+ H ++ SG + + +S+ ++ +ER G+ R + E+
Sbjct: 594 QADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQS 653
Query: 509 SVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSS-----E 563
G +R ++H + G+ + T+ + SS + + E+ SS+
Sbjct: 654 RDG--SRHPRSHHED-RAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGS 710
Query: 564 TGELPVQGDSQSQGDQHGESVQG------------------GHNNNPDTQRQGTPGEKNR 605
+L S+ G HG++ GH+ + DTQ G+
Sbjct: 711 RHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGH 770
Query: 606 ALEAVVPAVRGEDVQLTEDQE----QPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAG 661
++ + R + + Q + + G GP V H E +
Sbjct: 771 HQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSR 830
Query: 662 DENRKSLEIEITGALD------EDFTDQLSLMQLPGKGDSRNELKVQGPS--SKEEKGRA 713
+ + I G + + S+ + G + QG S S+ + G
Sbjct: 831 HSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSR 890
Query: 714 TEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSV 773
+ ++ T E D S ++ S D S AG+G + S + SSV
Sbjct: 891 SASRTTRNEEQSRDGSR----HSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSV 946
Query: 774 PWSSLEKQMQRDQE 787
S + D E
Sbjct: 947 SQDSDSEGHSEDSE 960
Score = 45.8 bits (107), Expect = 2e-04
Identities = 118/615 (19%), Positives = 203/615 (33%), Gaps = 117/615 (19%)
Query: 149 SGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKT 208
SG+ N +E H S H D D Q +T+ GQ +
Sbjct: 963 SGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSG--GQAAS 1020
Query: 209 NKPMAGSKKTSSPTERKGQDKEISQEGDEPA---REQSVSKIRDQFGEQEGNLATQSSPP 265
+ A SSP ER G + S + + R Q+ S +RD G+ +Q+S
Sbjct: 1021 SHEQA----RSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDS--GHWGSSGSQAS-- 1072
Query: 266 KEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSK 325
D E +E+ S+ Q +D P Q Q +AR S +
Sbjct: 1073 ---------DSEGHSEE---SDTQSVSGHGQDGPHQQS----HQESARDWSGGRSGRSGS 1116
Query: 326 DVCRMFDTQEPGKDADQTPAKT-KNLGEPEDYGRTSETQEKECETKD-LPVQYGSRNGSE 383
+ ++ ++ +T T + G + R S E +D + GSR G
Sbjct: 1117 FIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGR 1176
Query: 384 TSDMRDERKERRGPE---------------AHGTAGQKERDRKTRPLVLETQTQDGKYQE 428
++ +R G +HG +G + R+TR + Q+ DG
Sbjct: 1177 QGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRK---DKQSGDG---- 1229
Query: 429 LQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEE-AEHTKEGTAEAFVNSKNAP 487
GS +S H ++ SG + H ++ + +++
Sbjct: 1230 --------SRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSD 1281
Query: 488 AAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEG-S 546
+ER G+ R + E+ G G+ ED S +D
Sbjct: 1282 DSERLSGSASRNHHGSSREQSRDG-------------SRHPGFHQEDRASHGHSADSSRQ 1328
Query: 547 SETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRA 606
S T ++ +S G + S + S G++HG H + D+ R G + +
Sbjct: 1329 SGTHHTESSSHGQAVSSHEQA-----RSSPGERHGSR----HQQSADSSRHSGIGHRQAS 1379
Query: 607 LEAVVPAVRGED-VQLT------EDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQEST 659
RG Q+T ED + + H GP H E+
Sbjct: 1380 SAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGP---------HQQSHKESARGQ 1430
Query: 660 AGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKG-RATEAQN 718
+G+ + +S L Q+ S + PS+ +G R +A+N
Sbjct: 1431 SGESSGRSRSF---------------LYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARN 1475
Query: 719 TLLESLDEDNSASLK 733
+ S +D +++
Sbjct: 1476 SSRHSASQDGQDTIR 1490
Score = 40.8 bits (94), Expect = 0.006
Identities = 91/483 (18%), Positives = 163/483 (33%), Gaps = 65/483 (13%)
Query: 135 PSGMASSSQLIPEESGAVGNNR-VDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVA 193
P + + ++S + G++ + W + + N G A E + ++H + +
Sbjct: 3529 PRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGH 3588
Query: 194 QDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGE 253
+ G G +S R + + A S I G
Sbjct: 3589 GHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGI----GH 3644
Query: 254 QEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAAR 313
+ + A + S + ++ D E +E ++ + S Q E R
Sbjct: 3645 GQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQ-----ESTRGR 3699
Query: 314 SPSQTQKSTDSKDVCRMFDTQEP--GKDADQTPAKTKNLGEP-EDYGRTSETQEKECETK 370
S ++ +S + E G+ T + + E D R S +QE + +
Sbjct: 3700 SAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIR 3759
Query: 371 DLPVQYGSRNGSETSDMRDERKERRGPE---------------AHGTAGQKERDRKTRPL 415
P GSR G ++ +R G +HG +G + R+TR
Sbjct: 3760 GHP---GSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRN- 3815
Query: 416 VLETQTQDG-KYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKE 474
E Q+ DG ++ + S A+ +Q E +G++VS + E
Sbjct: 3816 --EEQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVS---QDSDSE 3870
Query: 475 GTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGED 534
E + + +RE+++D + G + R T +H Q
Sbjct: 3871 AYPEDSERRSESASRNHHGSSREQSRD----GSRHPGSSHRDTASHVQ------------ 3914
Query: 535 PESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDT 594
SP QSD +S A E G+ SS + + QS+G H S H + T
Sbjct: 3915 -SSP-VQSD-------SSTAKEHGHFSSLSQDSAYHSGIQSRGSPHSSS--SYHYQSEGT 3963
Query: 595 QRQ 597
+RQ
Sbjct: 3964 ERQ 3966
>gi|171916097 repetin [Homo sapiens]
Length = 784
Score = 85.5 bits (210), Expect = 2e-16
Identities = 137/700 (19%), Positives = 259/700 (37%), Gaps = 62/700 (8%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQ-PCVLHAVEKNSNL 59
M QLL ++L VI+ FHKYA + + A L ELKQL+ EFGD Q P VE NL
Sbjct: 1 MAQLLNSILSVIDVFHKYAKGNGDCALLCKEELKQLLLAEFGDILQRPNDPETVETILNL 60
Query: 60 LNIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDG 119
L+ D +G I F E++L +F L+ CY + + + +E D TG
Sbjct: 61 LDQDRDGHIDFHEYLLLVFQLVQACYHKLDNKSHGGRTSQQERGQEGAQDCKFPGNTG-- 118
Query: 120 QWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPK 179
Q ++ +S PE ++ ++ +H+ SE D
Sbjct: 119 --------RQHRQRHEEERQNSHHSQPERQDGDSHHGQPERQDRDSHH---GQSEKQDRD 167
Query: 180 NKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPA 239
+ H + + Q ++ + +D + ++ + + K + +G A
Sbjct: 168 SHHSQPERQDRDSHHNQSERQDKDFSFDQSERQSQDSSSGKKVSHKSTSGQAKWQGHIFA 227
Query: 240 REQSVSKIRD-QFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQRE-- 296
+ I+D +G+ E + TQ S E + + +K Q L +E
Sbjct: 228 LNRCEKPIQDSHYGQSERH--TQQS---ETLGQASHFNQTNQQKSGSYCGQSERLGQELG 282
Query: 297 ------DEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNL 350
SS + Q + QT + S + T G+ + ++
Sbjct: 283 CGQTDRQGQSSHYGQTDRQDQSYHYGQTDRQGQSSHYSQ---TDRQGQSSHY--SQPDRQ 337
Query: 351 GEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTA---GQKE 407
G+ YG+ ++ +C D + G + + + + P+ + GQ +
Sbjct: 338 GQSSHYGQMD--RKGQCYHYDQTNRQGQGSHYSQPNRQGQSSHYGQPDTQDQSSHYGQTD 395
Query: 408 R-DRKTRPLVLETQTQDGKYQEL----QGLSKSKDAEKGSETQY--LSSEGGDQTHPELE 460
R D+ + E Q Q Y ++ QG + +G + Y +G + + + +
Sbjct: 396 RQDQSSHYGQTERQGQSSHYSQMDRQGQGSHYGQTDRQGQSSHYGQPDRQGQNSHYGQTD 455
Query: 461 GTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTH 520
S + ++G + + + + Q + G+++ +T
Sbjct: 456 RQGQSSHYGQTDRQGQSSHYSQPDKQGQSSHYGKIDRQDQSYHYGQPDGQGQSSHYGQTD 515
Query: 521 DQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQG--D 578
Q G +S + ++ + ++ SS G+ QG S G D
Sbjct: 516 RQGQSFHYGQPDRQGQSSHYSQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTD 575
Query: 579 QHGES-----VQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEH 633
+ G+S Q G + QGT G + +A G +L+ Q+ P + +
Sbjct: 576 RQGQSSHYIQSQTGEIQGQNKYFQGTEGTR----KASYVEQSGRSGRLS--QQTPGQEGY 629
Query: 634 KNQGPGTKGPGAAVEPNGHP--EAQESTAGDENRKSLEIE 671
+NQG G + + + NGH E +E + +++ +I+
Sbjct: 630 QNQGQGFQSRDS--QQNGHQVWEPEEDSQHHQHKLLAQIQ 667
Score = 37.0 bits (84), Expect = 0.083
Identities = 44/199 (22%), Positives = 79/199 (39%), Gaps = 24/199 (12%)
Query: 141 SSQLIPEESGAV-GNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTT 199
SS I ++G + G N+ E E S + ++ G E Q Q Q+
Sbjct: 580 SSHYIQSQTGEIQGQNKYFQGTEGTRKASYVEQSGRSGRLSQQTPGQEGYQNQGQGFQSR 639
Query: 200 EDNEGQLKTNKPMAGSK----------KTSSPTERKGQDKEI--SQEGDEPAR-EQSVSK 246
+ + + +P S+ + P KG+D + S++G A+ QS +
Sbjct: 640 DSQQNGHQVWEPEEDSQHHQHKLLAQIQQERPLCHKGRDWQSCSSEQGHRQAQTRQSHGE 699
Query: 247 IRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADL 306
+ E+E T E+ + PC Q+ RT K++ ++ QR D + +H
Sbjct: 700 GLSHWAEEEQGHQTWDRHSHESQEGPCGTQDRRTHKDEQNH------QRRDRQTHEH--- 750
Query: 307 PEQAAARSPSQTQKSTDSK 325
EQ+ R QT + ++
Sbjct: 751 -EQSHQRRDRQTHEDKQNR 768
Score = 36.6 bits (83), Expect = 0.11
Identities = 77/389 (19%), Positives = 137/389 (35%), Gaps = 41/389 (10%)
Query: 533 EDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGG---HN 589
+D S + Q+D + +G SS + Q D Q QG +G++ + G H
Sbjct: 385 QDQSSHYGQTDRQDQSSHYGQTERQGQSSHYS-----QMDRQGQGSHYGQTDRQGQSSHY 439
Query: 590 NNPDTQRQGTP-GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVE 648
PD Q Q + G+ +R ++ Q + + +G+ + G + +
Sbjct: 440 GQPDRQGQNSHYGQTDRQGQSSHYGQTDRQGQSSHYSQPDKQGQSSHYGKIDRQDQSYHY 499
Query: 649 PNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKE 708
+ Q S G +R+ + + S M G+ + QG SS
Sbjct: 500 GQPDGQGQSSHYGQTDRQGQSFHYGQPDRQGQSSHYSQMDRQGQSSHYGQTDRQGQSSHY 559
Query: 709 EKGRATEAQNTLLESLDEDNSASLKIQLETKE--------PVTSEEEDESPQELAGEGG- 759
+ + Q+ D +S IQ +T E T S E +G G
Sbjct: 560 GQ-TDRQGQSYHYGQTDRQGQSSHYIQSQTGEIQGQNKYFQGTEGTRKASYVEQSGRSGR 618
Query: 760 -DQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSP--LYQYLQEKIL-----Q 811
Q++P ++ + + Q + E + + L Q QE+ L
Sbjct: 619 LSQQTPGQEGYQNQGQGFQSRDSQQNGHQVWEPEEDSQHHQHKLLAQIQQERPLCHKGRD 678
Query: 812 QTNVTQEEHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGLPLDESPAG 871
+ + E+ +Q Q Q+ G L + E + +S SQ E P G
Sbjct: 679 WQSCSSEQGHRQAQTRQSHGEGLSHWA--EEEQGHQTWDRHSHESQ---------EGPCG 727
Query: 872 AQETPAPQALEDKQGHPQRERLVLQREAS 900
Q+ + +D+Q H +R+R + E S
Sbjct: 728 TQDR---RTHKDEQNHQRRDRQTHEHEQS 753
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 84.7 bits (208), Expect = 3e-16
Identities = 137/620 (22%), Positives = 243/620 (39%), Gaps = 107/620 (17%)
Query: 170 GEASEH----NDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERK 225
GE S+ DPK EGD +QE EG+ ++ AGS+ + E +
Sbjct: 1746 GEGSQRLNRDKDPKLGEAEGDAMAQE----------REGKTHNSETSAGSELGEAEQEGE 1795
Query: 226 GQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH 285
G IS+ G+ Q E NL +++ + + E
Sbjct: 1796 G----ISERGETGG----------QGSGHEDNLQGEAAAGGDQDPGQSDGAE-------- 1833
Query: 286 SNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPA 345
I+ P + E +P S+ + PE ++ + +S+DV + P + + P
Sbjct: 1834 -GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV------EAPEAEGEAQP- 1885
Query: 346 KTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQ 405
E ED ET E E E VQ S ++ + E EA T G+
Sbjct: 1886 ------ESEDV----ETPEAEWE-----VQPESEGAEAPEAEKEAQPETESVEALETEGE 1930
Query: 406 KERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYL-SSEGGDQTHPELEGTAV 464
E +++ + QE + ++ + + E++ + S E ++ PE E
Sbjct: 1931 D-----------EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979
Query: 465 SGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAP------LEKQSVGENTRVTK 518
E E T+E EA S++ A E +E ++ P + +S GE + +
Sbjct: 1980 LEVEVE-TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038
Query: 519 THDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGD 578
Q E + + + E+P +++E + E + EG + E+ ++ Q +++ +
Sbjct: 2039 GETQKTEGDAQPESDGVEAP--EAEEEAQEAEGEVQEAEGEAHPESEDVDAQ-EAEGEAQ 2095
Query: 579 QHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQP-ARGEHKNQG 637
E V+ P+ + GE +A P GE +E E P A GE + +
Sbjct: 2096 PESEGVEA-----PEAE-----GEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES 2145
Query: 638 PGTKGPGAAVEPNGHPEAQES-TAGDENRKSLE-IEITGALDEDFTDQLSLMQLPGKGDS 695
G + A E E E+ A +E + LE +E A E + + +G++
Sbjct: 2146 EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
Query: 696 RNELK-VQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQEL 754
+ EL+ V+ P ++EE E +E+ + + A + + ET+ E+ SPQ
Sbjct: 2206 QPELEGVEAPEAEEEAQPEPEG----VETPEAEGEAQPESEGETQ-----GEKKGSPQVS 2256
Query: 755 AGEGGDQKSPAKKEHNSSVP 774
G+G +S E +S VP
Sbjct: 2257 LGDG---QSEEASESSSPVP 2273
Score = 83.2 bits (204), Expect = 1e-15
Identities = 117/531 (22%), Positives = 194/531 (36%), Gaps = 63/531 (11%)
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
RE KTHN A + EG + E EDN + AG +
Sbjct: 1772 REGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDN----LQGEAAAGGDQDPG 1827
Query: 221 PTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRT 280
++ + EG+ + V + QE ++ P E + P + E +
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE--GEAQPESEDVEAPEAEGEAQP 1885
Query: 281 EKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEP---- 336
E E +++ P + E +P S+ A+ PE + + Q T+S + EP
Sbjct: 1886 ESE---DVETPEAEWEVQPESEGAEAPE-----AEKEAQPETESVEALETEGEDEPESEG 1937
Query: 337 --GKDADQTPAKTKNLGEPEDYGRTSETQEKEC-------ETKDLPVQYGSRNGSETSDM 387
++A++ + + +PE S+ E+E E ++ V+ G +
Sbjct: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997
Query: 388 RD-----------ERKERRGPEAHGTAGQ-KERDRKTRPLVLETQTQDGKYQ-ELQGLSK 434
D E +E PE+ G Q K + + + ETQ +G Q E G+
Sbjct: 1998 EDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEA 2057
Query: 435 SKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLG 494
+ E+ E + E + HPE E V +EA EG A+ AP AE G
Sbjct: 2058 PEAEEEAQEAEGEVQEAEGEAHPESED--VDAQEA----EGEAQPESEGVEAPEAE---G 2108
Query: 495 ARERTQDL-APL---EKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETP 550
++ + + AP E Q E + + E +G + +D E EG
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
Query: 551 NSLASEEGNSSSETGELPVQGDSQSQGDQHG-ESVQGGHNNNPDTQRQGTPGEKNRALEA 609
A EE E E P + + ++Q + G E+ + P+ + P A E
Sbjct: 2169 ---AEEEAQPELEGVEAP-EAEGEAQPESEGIEAPEAEGEAQPELEGVEAP----EAEEE 2220
Query: 610 VVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA 660
P G + E + QP E + QG P ++ EA ES++
Sbjct: 2221 AQPEPEGVETPEAEGEAQP-ESEGETQGEKKGSPQVSLGDGQSEEASESSS 2270
Score = 74.7 bits (182), Expect = 4e-13
Identities = 121/548 (22%), Positives = 201/548 (36%), Gaps = 60/548 (10%)
Query: 146 PEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTE----D 201
PE G + E++ P EA P+++ +E E EV + + E +
Sbjct: 1854 PEAEGDAQEAEGEAQPESEDVEAP-EAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912
Query: 202 NEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSK---IRDQFGEQEGNL 258
E Q +T A + E +G + + ++E + A Q+ + I Q E+E
Sbjct: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--- 1969
Query: 259 ATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPE----QAAARS 314
A S EA + E QE E + S E P + ++ PE +A +S
Sbjct: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKS 2029
Query: 315 PSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQ-EKECETKDLP 373
+ + + + D Q P D + P + E E G E + E E++D+
Sbjct: 2030 EGEEAQEVEGETQKTEGDAQ-PESDGVEAPEAEEEAQEAE--GEVQEAEGEAHPESEDVD 2086
Query: 374 VQYGS------RNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQ 427
Q G E + E ++ G EA T G+ + + + +E +G+ Q
Sbjct: 2087 AQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG----IEAPEAEGEAQ 2142
Query: 428 ELQGLSKSKDAEKGSETQ---YLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSK 484
+++DAE ++ + + E ++ PELEG V EAE + +E +
Sbjct: 2143 PESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEG--VEAPEAEGEAQPESEGIEAPE 2200
Query: 485 NAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDE 544
A+ L E + + + G T + QP E E QGE SP +
Sbjct: 2201 AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQP-ESEGETQGEKKGSPQVSLGD 2259
Query: 545 GSSETPNSLASEEGNSS-----SETGELPVQ------GDSQSQGDQHGESVQG------- 586
G SE + +S S G+ P Q G S S+ G Q
Sbjct: 2260 GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHV 2319
Query: 587 -GHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGE------HKNQGPG 639
G +PD + GTP + +A + E + P +G ++Q G
Sbjct: 2320 LGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALG 2379
Query: 640 TKGPGAAV 647
+ P AV
Sbjct: 2380 SLAPTEAV 2387
Score = 72.4 bits (176), Expect = 2e-12
Identities = 165/801 (20%), Positives = 276/801 (34%), Gaps = 130/801 (16%)
Query: 164 KTHNFPGEASEHNDPKNKHLE---GDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
+T GE + + + + +E G+ +E Q + E EG L+ G K+
Sbjct: 1340 ETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGL 1399
Query: 221 PTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRT 280
P E +E+S+ + S+ D E+E A+ S+ P P E E T
Sbjct: 1400 PEEGSVHGQELSEASSPDGKG---SQEDDPVQEEEAGRASASAEPC-----PAEGTEEPT 1451
Query: 281 EKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQ-KSTDSKDVCRMFDTQEPGKD 339
E H + +P S L + A Q ++ ++ +
Sbjct: 1452 EPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAA 1511
Query: 340 ADQTPAKTKNLGEPEDYGRTSETQEKECETK--------DLPVQYGSRNGSETSDMRDER 391
D P L + + + E + DL Q + + + +
Sbjct: 1512 LDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDS 1571
Query: 392 KERRGPEAHGTAG----QKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYL 447
+R + G AG + R+ T L+L+TQ + + + L+ LS + G
Sbjct: 1572 TKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
Query: 448 SSEGGDQTHPELEGTAVS--GEEAEHTKEGTAEAFVNSKNAPAAER-----TLGARERTQ 500
+ E P L S GEEAE + EA V K +P + + T G +
Sbjct: 1632 TLED----EPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAF 1687
Query: 501 DLAPLEKQSVGENT-------RVTKTHDQPV-----------------------EEEDGY 530
DL + ++ GE+T KTH P E EDG
Sbjct: 1688 DLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGE 1747
Query: 531 ------QGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQS-------QG 577
+ +DP+ + D + E + E ++ SE GE +G+ S QG
Sbjct: 1748 GSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQG 1807
Query: 578 DQHGESVQG----GHNNNPDTQRQGTPG-EKNRALEAVVPAVRGEDVQLTEDQEQPARGE 632
H +++QG G + +P Q G G E A P G + E Q A GE
Sbjct: 1808 SGHEDNLQGEAAAGGDQDPG-QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGE 1866
Query: 633 HKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGK 692
+ + + P A E PE+ E E ++ E GA + + +
Sbjct: 1867 AQPESEDVEAPEA--EGEAQPES-EDVETPEAEWEVQPESEGAEAPEAEKEAQ-----PE 1918
Query: 693 GDSRNELKVQGPSSKEEKG-RATEAQNTLLESLDEDNSASLKIQL-ETKEPVTSEEEDES 750
+S L+ +G E +G A EA+ E+ + S I+ E +E E ED
Sbjct: 1919 TESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVE 1978
Query: 751 PQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKIL 810
E+ E + + A+ E + V E +MQ +E E V + P +
Sbjct: 1979 ALEVEVETQEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSE------- 2030
Query: 811 QQTNVTQEEHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGLPLDESPA 870
+E + + + + G +QP + G+ E+
Sbjct: 2031 -----GEEAQEVEGETQKTEGD-----------------------AQPESDGVEAPEAEE 2062
Query: 871 GAQETPAPQALEDKQGHPQRE 891
AQE + + HP+ E
Sbjct: 2063 EAQEAEGEVQEAEGEAHPESE 2083
Score = 66.2 bits (160), Expect = 1e-10
Identities = 110/520 (21%), Positives = 191/520 (36%), Gaps = 53/520 (10%)
Query: 383 ETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKY-QELQGLS-KSKDAEK 440
E S + K+ + EA G A +ER+ KT ++ G+ QE +G+S + + +
Sbjct: 1747 EGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQ 1806
Query: 441 GS----ETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGAR 496
GS Q ++ GGDQ + +G E E EA S+ A E A+
Sbjct: 1807 GSGHEDNLQGEAAAGGDQDPGQSDGA-----EGIEAPEAEGEAQPESEGVEAPEAEGDAQ 1861
Query: 497 ERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASE 556
E A E Q E+ + + E + + + E EG+ ++
Sbjct: 1862 E-----AEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQ 1916
Query: 557 EGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRG 616
S E E + + +S+G + E+ + TQ + E A E P
Sbjct: 1917 PETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESED 1976
Query: 617 EDVQLTEDQEQPARGEHKNQGPGTKGPGAAVE-PNGHPEAQESTAGDENRKSLEIEITGA 675
+ E + Q A GE + + + P A E EAQ + G E + E E
Sbjct: 1977 VEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQE 2036
Query: 676 LDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKG-RATEAQNTLLESLDEDNSASLKI 734
++ G+++ K +G + E G A EA+ E+ E A +
Sbjct: 2037 VE---------------GETQ---KTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEA 2078
Query: 735 QLETKEPVTSEEEDESPQELAG-EGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVER 793
E+++ E E E+ E G E + + A+K P E + Q + E
Sbjct: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP--ETEGEAQPESEGIEAPE 2136
Query: 794 GAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYS 853
+ P + ++ + + + E + + + + PEL V +
Sbjct: 2137 AEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE-------- 2188
Query: 854 QASQPYTRGLPLDESPAGAQE----TPAPQALEDKQGHPQ 889
+QP + G+ E+ AQ AP+A E+ Q P+
Sbjct: 2189 --AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
Score = 65.5 bits (158), Expect = 2e-10
Identities = 122/565 (21%), Positives = 205/565 (36%), Gaps = 90/565 (15%)
Query: 334 QEPGKDADQTPAKTKNLGEPEDYGR----TSETQEKECETKDLPVQYGSRNGSETSDMRD 389
+ GK + + LGE E G ET + +D + G + D
Sbjct: 1771 EREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSD 1830
Query: 390 ERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSS 449
+ PEA G A + +E +G QE +G +A+ SE
Sbjct: 1831 GAEGIEAPEAEGEAQPESEG-------VEAPEAEGDAQEAEG-----EAQPESE------ 1872
Query: 450 EGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQS 509
D PE EG A E T E E S+ A A E A+ T+ + LE +
Sbjct: 1873 ---DVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETE- 1928
Query: 510 VGENTRVTKTHDQPVEEEDGYQGE---DPESPFTQSDEGSSET-PNSLASEEGNSSSETG 565
GE+ ++ + EE + E PES +S E E P S E ET
Sbjct: 1929 -GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQ 1987
Query: 566 ELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQ 625
E +G++Q + + G + + Q ++ +EA P GE+ Q E +
Sbjct: 1988 E--AEGEAQPESEDVEAPEAEGEMQEAEEEAQ----PESDGVEAQ-PKSEGEEAQEVEGE 2040
Query: 626 EQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLS 685
Q G+ + + G + P A EAQE+ E E+ A E +
Sbjct: 2041 TQKTEGDAQPESDGVEAPEA------EEEAQEA----------EGEVQEAEGEAHPESED 2084
Query: 686 LMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSE 745
+ +G+++ E +G + E +G A +A+ +E+ + + A Q E++ E
Sbjct: 2085 VDAQEAEGEAQPES--EGVEAPEAEGEAQKAEG--IEAPETEGEA----QPESEGIEAPE 2136
Query: 746 EEDESPQELAG-EGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQY 804
E E+ E G E D + A+ E + + E++ Q + E + P +
Sbjct: 2137 AEGEAQPESEGVEAQDAEGEAQPE-SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEG 2195
Query: 805 LQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGLP 864
++ + E + Q ++ PE + +QP G+
Sbjct: 2196 IE--------APEAEGEAQPELEGVEAPEA------------------EEEAQPEPEGVE 2229
Query: 865 LDESPAGAQETPAPQALEDKQGHPQ 889
E+ AQ + +K+G PQ
Sbjct: 2230 TPEAEGEAQPESEGETQGEKKGSPQ 2254
Score = 53.1 bits (126), Expect = 1e-06
Identities = 94/467 (20%), Positives = 160/467 (34%), Gaps = 62/467 (13%)
Query: 95 ELRQVTKPEKEKLDDVDVQATT------GDGQWTVGTSPTQEKRMLPSGMASSSQLIPEE 148
E + +PE E ++ ++ + + Q + E + P SQ EE
Sbjct: 1910 EAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE 1969
Query: 149 SGAVGNNRVDPWREAKTHNFPGEAS-EHNDPKNKHLEGDEQSQEVAQDIQTTEDN-EGQL 206
+ + E +T GEA E D + EG+ QE ++ Q D E Q
Sbjct: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGE--MQEAEEEAQPESDGVEAQP 2027
Query: 207 KTNKPMAGSKKTSSPTERKGQDKEISQEGDE-PAREQSVSKIRDQFGEQEGNLATQSS-- 263
K+ A ++ T++ D + +G E P E+ + + E EG +S
Sbjct: 2028 KSEGEEA--QEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV 2085
Query: 264 ----------PPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAAR 313
P E + P E E +K I+ P + E +P S+ + PE
Sbjct: 2086 DAQEAEGEAQPESEGVEAP----EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA 2141
Query: 314 SPSQTQKSTDSKDVCRMFDTQEPGKDA----DQTPAKTKNLGEPEDYGRTSETQE----K 365
P + +++D + G +A ++ + + + PE G E
Sbjct: 2142 QPE--SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP 2199
Query: 366 ECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTA-----GQKERDRKTRPLVLETQ 420
E E + P G + + E + PEA G A G+ + ++K P +
Sbjct: 2200 EAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSP---QVS 2256
Query: 421 TQDGKYQELQGLSKSKDAEK-------GSETQYLSSEGGDQTHPELEGTAVSG------E 467
DG+ +E S ++ G +T + G QT P + G
Sbjct: 2257 LGDGQSEEASESSSPVPEDRPTPPPSPGGDTPH--QRPGSQTGPSSSRASSWGNCWQKDS 2314
Query: 468 EAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENT 514
E +H T S P AER + E+ +G T
Sbjct: 2315 ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRT 2361
Score = 37.7 bits (86), Expect = 0.049
Identities = 57/244 (23%), Positives = 97/244 (39%), Gaps = 35/244 (14%)
Query: 362 TQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQT 421
T E E E +D Q S N + ++ + + + GT G+ ++ + + ET+T
Sbjct: 1271 TNEDEAE-RDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQ--LEETKT 1327
Query: 422 QDGKYQELQGLSKSKDAE-KGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEG----- 475
++G +E L ++K+ E +G + + E ++T E G G + E KEG
Sbjct: 1328 EEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE--GLQEEGVQLEEVKEGPEGGL 1385
Query: 476 ---TAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQ- 531
E + + P E ++ +E ++ +P K S D PV+EE+ +
Sbjct: 1386 QGEALEEGLKEEGLPE-EGSVHGQELSEASSPDGKGS---------QEDDPVQEEEAGRA 1435
Query: 532 --------GEDPESPFTQSDEGSSETPNSLASEEGNSSSETG-ELPVQGDSQSQGDQHGE 582
E E P T+ SET S + + S E G E P Q +
Sbjct: 1436 SASAEPCPAEGTEEP-TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQ 1494
Query: 583 SVQG 586
QG
Sbjct: 1495 PTQG 1498
>gi|7706635 cornulin [Homo sapiens]
Length = 495
Score = 82.4 bits (202), Expect = 2e-15
Identities = 134/571 (23%), Positives = 206/571 (36%), Gaps = 99/571 (17%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGD-FFQPCVLHAVEKNSNL 59
MPQLL+N+ +IE F +YA + N LT ELK+L++ EF D +P V++ L
Sbjct: 1 MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRL 60
Query: 60 LNIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDG 119
L+ D G + F EF++ +F + C+ K+L S E L G+G
Sbjct: 61 LDEDHTGTVEFKEFLVLVFKVAQACF---KTLSESAEGACGSQESGSLHS-GASQELGEG 116
Query: 120 QWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPK 179
Q S T+ R S + G+ G NR + G+A+
Sbjct: 117 Q----RSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQ-------GQATGSAWVS 165
Query: 180 NKHLEGDEQSQE-VAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEP 238
+ + + QSQE ++ IQ + E K AG K + TE + + + ++E D
Sbjct: 166 SYDRQAESQSQERISPQIQLSGQTEQTQK-----AGEGKRNQTTEMRPERQPQTREQDR- 219
Query: 239 AREQSVSKIRDQFGEQEGNLATQS-SPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQRED 297
Q GE TQ+ + + ++ Q RT K+ + R
Sbjct: 220 ---------AHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQ--NRGT 268
Query: 298 EPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYG 357
E Q QA +Q Q T + QTP +T G
Sbjct: 269 ETHGQGRSQTSQAVTGGHAQIQAGTHT-----------------QTPTQTVEQDSSHQTG 311
Query: 358 RTS-ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLV 416
TS +TQE S NG + RG E HG + T
Sbjct: 312 STSTQTQE-------------STNG-----------QNRGTEIHGQGRSQTSQAVTGG-- 345
Query: 417 LETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGT 476
TQ Q G + E +S+ G + +G QT P SG+
Sbjct: 346 -HTQIQAGSHTETVEQDRSQTVSHGGARE----QGQTQTQPG------SGQRWMQVSNPE 394
Query: 477 AEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQP-VEEEDGYQGEDP 535
A V A T R+ P + G+ R QP V E+
Sbjct: 395 AGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDR------QPTVVGEEWVDDHSR 448
Query: 536 ESPFTQSDEGSSETPNSLASEEGNSSSETGE 566
E+ + D+G+ T S++S +G ++++ E
Sbjct: 449 ETVILRLDQGNLHT--SVSSAQGQDAAQSEE 477
Score = 43.1 bits (100), Expect = 0.001
Identities = 71/358 (19%), Positives = 124/358 (34%), Gaps = 59/358 (16%)
Query: 342 QTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHG 401
QT + Y R +E+Q +E + + + + + + + + PE
Sbjct: 153 QTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQP 212
Query: 402 TAGQKERDRKTRPLVLE--TQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPEL 459
+++R +T V TQTQ G Q ++ S + +TQ + T+ +
Sbjct: 213 QTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQ-------EATNDQN 265
Query: 460 EGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKT 519
GT G+ T + G + Q G +T+ T
Sbjct: 266 RGTETHGQGRSQTSQAVT----------------GGHAQIQ---------AGTHTQ---T 297
Query: 520 HDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQ 579
Q VE++ +Q S TQ+ E S+ N G S+T + G +Q Q
Sbjct: 298 PTQTVEQDSSHQ---TGSTSTQTQE-STNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGS 353
Query: 580 HGESVQ---------GGHNNNPDTQRQGTPGEK-----NRALEAVVPAVRGEDVQLTEDQ 625
H E+V+ GG TQ Q G++ N VP + + TE
Sbjct: 354 HTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESG 413
Query: 626 EQPARGEHK----NQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDED 679
Q H +G G + P E ++E+ ++ +L ++ A +D
Sbjct: 414 RQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQD 471
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 72.8 bits (177), Expect = 1e-12
Identities = 86/641 (13%), Positives = 219/641 (34%), Gaps = 47/641 (7%)
Query: 136 SGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQD 195
S +S S + S + ++ D + + +S+ +D N D + D
Sbjct: 695 SSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754
Query: 196 IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQE 255
+ D+ ++ S + S D S + + + S D +
Sbjct: 755 SSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD 814
Query: 256 GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQE----PPLQREDEPSSQHADLPEQAA 311
+ + S+ + D ++ S+ + R D SS +D + +
Sbjct: 815 SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD--SSNSSDSSDSSD 872
Query: 312 ARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKD 371
+ + S + S+DS + D+ + +D + + N + D +S++ E + D
Sbjct: 873 SSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS-NSSD 931
Query: 372 LPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQG 431
S N S++SD D + ++ + + D +
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSD-------------SSDSNSSDSSD 978
Query: 432 LSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAER 491
S S D+ S+ SS+ D + + ++ S + ++ + + NS ++ +
Sbjct: 979 SSNSSDSSDSSD----SSDSSDSS--DSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032
Query: 492 TLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPN 551
+ + + + + +++ + + D + + +S + SS++ N
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092
Query: 552 SLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVV 611
S S + + SS++ + DS D S +++ D+ + + + E+
Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-- 1150
Query: 612 PAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIE 671
++ + + + + ++ N + S + D + S +
Sbjct: 1151 ----------SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1200
Query: 672 ITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSAS 731
+ + D + S DS + S + ++++ ++ +S D NS+
Sbjct: 1201 SSDSSDSSDSSDSS--------DSSDSSDSSDSSDSSDSNESSDSSDSS-DSSDSSNSSD 1251
Query: 732 LKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSS 772
++ + + ++ Q +G G + S + + S
Sbjct: 1252 SSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGS 1292
Score = 72.4 bits (176), Expect = 2e-12
Identities = 94/664 (14%), Positives = 230/664 (34%), Gaps = 33/664 (4%)
Query: 140 SSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHL-EGDEQSQEVAQDIQT 198
S+S +S GNN D ++ + ++S+ + + + + + S + D +
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNS 576
Query: 199 TEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNL 258
+ D++ + + S + S D S + + + + S SK E + +
Sbjct: 577 SSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS-DSSDSKSDSSKSESDSSD 635
Query: 259 ATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQT 318
+ S ++ D ++ SN + + SS +D + + S +
Sbjct: 636 SDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDS 695
Query: 319 QKSTDSKDVCRMFDTQEP----GKDADQTPAKTKNLGEPEDYGRTSETQEKE-----CET 369
S++S D D+ +++ + + + N + D +S++ + ++
Sbjct: 696 SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755
Query: 370 KDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQEL 429
D S + S++SD D +++ ++ + + +
Sbjct: 756 SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSD------------SSDSSNSSDS 803
Query: 430 QGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAA 489
S S D+ S++ SS D ++ + + ++ + + + + +S N +
Sbjct: 804 SNSSDSSDSSDSSDSD--SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Query: 490 ERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSET 549
+ + + + + ++ + + D D D +S + + SS++
Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD----SSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 550 PNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEA 609
NS S E ++SS+ +S D S +N+ D+ + N + ++
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS-DS 976
Query: 610 VVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLE 669
+ + ++ + + N + ++ N + S + + + S
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 670 IEITGALD-EDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDN 728
+ + + D D +D DS + S + ++E+ ++ S D+
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDS 1096
Query: 729 SASLKIQLETKEPVTSEEEDESPQELAGEGGD--QKSPAKKEHNSSVPWSSLEKQMQRDQ 786
S S + +S+ D S + + D S + NSS S E D
Sbjct: 1097 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDS 1156
Query: 787 EPCS 790
S
Sbjct: 1157 SDSS 1160
Score = 60.1 bits (144), Expect = 9e-09
Identities = 67/474 (14%), Positives = 166/474 (35%), Gaps = 17/474 (3%)
Query: 136 SGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQD 195
S +S S + S + +NR D + + + ++S +D + + + + D
Sbjct: 838 SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD-SSDSSNSSDSSDSSDSNESSNSSDSSD 896
Query: 196 IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQE 255
+ D++ +N + SS + + S D S S D +
Sbjct: 897 SSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS-SDSSDSSNSSD 955
Query: 256 GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSP 315
+ ++ SS +++ D + S+ + + SS +D + + +
Sbjct: 956 SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015
Query: 316 SQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQ 375
S + S++S D D+ + +D + + + S ++ D
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1075
Query: 376 YGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKS 435
S + SE+SD D ++ ++ + + + S S
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSS---------DSSDSSDSSDSSNSSDS 1126
Query: 436 KDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGA 495
D+ S++ S+ E ++ S + ++ + + +S ++ + + +
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1186
Query: 496 RERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLAS 555
+ + + +++ + + D + + +S + S+E S + +S +S
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS--SDSNESSDSSDSSDSS 1244
Query: 556 EEGNSSSETGELPVQGDSQSQGDQHGESVQ---GGHNNNPDTQRQGTPGEKNRA 606
+ N SS++ + DS S + +S G+NN D+ + N +
Sbjct: 1245 DSSN-SSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHS 1297
Score = 51.6 bits (122), Expect = 3e-06
Identities = 57/278 (20%), Positives = 111/278 (39%), Gaps = 21/278 (7%)
Query: 527 EDGYQGEDPESPFTQSDEGSSETPNSLASEEGNS---SSETGELPVQGDSQSQGDQHGES 583
+DG++GE S + + S T ++LA+EEGN + +TG+ G G + +
Sbjct: 73 QDGHKGEGNGSKWAEVGGKSFSTYSTLANEEGNIEGWNGDTGKAETYGHDGIHGKEENIT 132
Query: 584 VQGGH------NNNPDTQRQGTPG--EKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKN 635
G +N T R T G +KN V A EDV + ++ G + +
Sbjct: 133 ANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNNS 192
Query: 636 QGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDS 695
+ + G+ + + E E+T ED S G G
Sbjct: 193 TDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGAD 252
Query: 696 RNELKVQGPSSKEEKGRATEAQNTLL------ESLDEDNSASLKIQLETKEPVTSEEEDE 749
+E + G EE G ++ N ++D+ +S+ ++KE E +++
Sbjct: 253 EDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKED 312
Query: 750 SPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQE 787
E+ G+ K+ +E+++ +P + ++++ Q+
Sbjct: 313 PHNEVDGD----KTSKSEENSAGIPEDNGSQRIEDTQK 346
Score = 51.6 bits (122), Expect = 3e-06
Identities = 111/672 (16%), Positives = 235/672 (34%), Gaps = 49/672 (7%)
Query: 129 QEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQ 188
+E+ + +G+ +I + +GA + + + T N + HN+ E
Sbjct: 127 KEENITANGIQGQVSII-DNAGATNRSNTNGNTDKNTQNGDVGDAGHNEDV---AVVQED 182
Query: 189 SQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIR 248
+VA +T DNE ++ N +G EI+ + + +++
Sbjct: 183 GPQVAGSNNST-DNEDEIIENS-----------CRNEGNTSEITPQINSKRNGTKEAEVT 230
Query: 249 DQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPE 308
GE G + SP ++ E E+ N ++ + + H +
Sbjct: 231 PGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDD 290
Query: 309 QAAARSPSQTQKSTDSKDVCRMFDTQEPGK--DADQTPAKTKN-LGEPEDYG--RTSETQ 363
S +++DSK+ ++P D D+T +N G PED G R +TQ
Sbjct: 291 H-----DSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQ 345
Query: 364 EKECETKDLPVQYGSRNGSETSDM---RDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
+ + V+ SET + +D+ E +GP + KE + E +
Sbjct: 346 KLN-HRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGN-----EGK 399
Query: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
G++ + G K ++ + ++ EG Q S ++ +G
Sbjct: 400 EDKGQHGMILGKGNVK-----TQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYD 454
Query: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT 540
+ K+ + D A E + ++R +++ E +D G D +
Sbjct: 455 FDDKSMQGDDPNSSDESNGNDDANSESDN-NSSSRGDASYNSD-ESKDNGNGSDSKGAED 512
Query: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP 600
+ +S+T NS ++ GN+ ++ + G +S S +++ D+
Sbjct: 513 DDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSS-DSDS 571
Query: 601 GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEA--QES 658
+ N + ++ D ++ + + + + ++ + ++ ES
Sbjct: 572 SDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSES 631
Query: 659 TAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQN 718
+ D + KS + + D +D DS + SS + ++++
Sbjct: 632 DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSS- 690
Query: 719 TLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSL 778
+S D NS+ ++ + +S+ D S + S + NSS S
Sbjct: 691 ---DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 779 EKQMQRDQEPCS 790
+ D S
Sbjct: 748 DSSNSSDSSDSS 759
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 69.3 bits (168), Expect = 2e-11
Identities = 102/596 (17%), Positives = 234/596 (39%), Gaps = 62/596 (10%)
Query: 205 QLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSP 264
++K+ + + +K+ T + E +Q +E E+ ++ E+EG ++
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 265 PKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDS 324
+E T+ P ++ EKE S + +E+ S A PE+ A+SP++ + +
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPV------KEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 325 KDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSET 384
K P K+ ++P + K+ PE S + K E P + +++ +E
Sbjct: 551 K---------SPAKEEAKSPPEAKS---PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 385 SDMRDER---KERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKG 441
+ KE A + KE + + + + +E + K+K EK
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 442 SETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQD 501
++ ++ ++ A S E+A+ + A++ +K +P E +
Sbjct: 659 ------EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK-SPVKEEAKSPEK---- 707
Query: 502 LAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSS 561
K V E + + PV+EE E +SP + + + + ++ +
Sbjct: 708 ----AKSPVKEEAKSPEKAKSPVKEE-AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762
Query: 562 SETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQL 621
S + P + +++S D+ E + +P + +P + L+ A +++
Sbjct: 763 SPEAKTPAKEEARSPADKFPEKAK-----SPVKEEVKSPEKAKSPLKEDAKAPE-KEIPK 816
Query: 622 TEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFT 681
E+ + P + E K Q K P E P ++ +++K
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK--------------- 861
Query: 682 DQLSLMQLP-GKGDSRNELKVQGPSSKEEKGRATEAQN-TLLESLDEDNSASLKIQLETK 739
++ + P K + + E V+ P + + + EA++ + + +++ A ++++ + K
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 740 EPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGA 795
+E + P + + + PA+K+ + + E++ ++ +E E A
Sbjct: 922 PKEKTEVAKKEPDD--AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Score = 67.0 bits (162), Expect = 7e-11
Identities = 113/581 (19%), Positives = 225/581 (38%), Gaps = 51/581 (8%)
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDE----PARE 241
+EQ++E + TE+ E + K + E +G ++E ++ G+E P E
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGK----------EEEGGEEEEAEGGEEETKSPPAE 507
Query: 242 QSVS---KIRDQFGEQEGNLATQSSPPKEATQRPCE-----------DQEVRTEKEKHSN 287
++ S + + E+ + A SP KE + P E +E ++ E S
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 288 IQEPPLQREDEPSSQHADLPEQAAARSPSQTQ-----KSTDSKDVCRMFDTQEPGKDADQ 342
+E + S + A P + A+SP++ + KS ++ + + P K+ +
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 343 TPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSET-SDMRDERKERRGPEAHG 401
+PA+ K+ PE ++ + K E P + +++ + S ++ E K ++
Sbjct: 628 SPAEVKS---PEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 402 TAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEG 461
A K ++ P+ E ++ + ++ ++K EK ++ ++ ++
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVK--EEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 462 TAVSGEEAEH-TKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTH 520
A S E+A+ K T + PA E AR K V E + +
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE---ARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 521 DQPVEEE-DGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQ 579
P++E+ + E P+ +S E P + +E +E + P ++ + D
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS 859
Query: 580 HGESVQGGHNNNPDTQRQGTPG-EKNRALEAVVPAVRGEDVQL--TEDQEQPARGEHKNQ 636
E P + + P EK + + ED + T ++E PA+ E K
Sbjct: 860 KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919
Query: 637 G-PGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDS 695
P K A EP+ + S ++ + E + T ++ + K D
Sbjct: 920 AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979
Query: 696 RNELK--VQGPSSKEEKGRATEAQNTL-LESLDEDNSASLK 733
+ K + + K EK +T+ +++ E ED +A K
Sbjct: 980 KTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 52.0 bits (123), Expect = 2e-06
Identities = 87/411 (21%), Positives = 163/411 (39%), Gaps = 39/411 (9%)
Query: 415 LVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKE 474
+++E QT++ + E + K+A+ E + EGG++ E AE
Sbjct: 455 VIVEEQTEETQVTEEVTEEEEKEAK---EEEGKEEEGGEEEEAEGGEEETKSPPAEEAAS 511
Query: 475 GTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGED 534
EA K + + E+ + +P E +S + K + E + E+
Sbjct: 512 PEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE 571
Query: 535 PESPFTQSDEGSSETPNSLASEEGNS-----SSETGELPVQGDSQSQGDQHG----ESVQ 585
+SP ++ S E S A EE S S E + PV+ +++S + E+
Sbjct: 572 AKSP---AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 586 GGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGA 645
+P+ + T E +A P E+ + E + P + E K+ K P
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSP--EKEEAKSPEKAKSPVKAEAKSPEKA-KSPVK 685
Query: 646 AVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPS 705
A + PE +S +E KS E + +E + + + + P K +++ K + P
Sbjct: 686 AEAKS--PEKAKSPVKEE-AKSPEKAKSPVKEEAKSPEKA--KSPVKEEAKTPEKAKSPV 740
Query: 706 SKE----EKGRATEAQNTL--------LESLDEDNSASLKIQLETKEPVTSE----EEDE 749
+E EK ++ E TL + +E S + K + K PV E E+ +
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK 800
Query: 750 SPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSP 800
SP + + +++ P K+E S V ++++ + P E ++P
Sbjct: 801 SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP 851
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 67.4 bits (163), Expect = 6e-11
Identities = 155/765 (20%), Positives = 275/765 (35%), Gaps = 84/765 (10%)
Query: 129 QEKRMLPSGMASSSQLIPEESGAVGNNR-----VDPWREAKTHNFPGEASEHNDPKNKHL 183
+E L G+A Q E GA + V PW K P + +K
Sbjct: 574 EEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKE- 632
Query: 184 EGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQ-DKEISQEGDEPAREQ 242
DE + + + +TE +++ + M GS + P E K + D +S E
Sbjct: 633 --DELDKVKSATLSSTESTASEMQ--EEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSS 688
Query: 243 SVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQ 302
R ++EG ++A + +D+E T+ + + P Q
Sbjct: 689 KKRARRGSSSDEEGGPKAMGGDHQKADEAG-KDKETGTDGILAGSQEHDP--------GQ 739
Query: 303 HADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSET 362
+ PEQA SP++ + + + R+ ++ K + ++ G ++
Sbjct: 740 GSSSPEQAG--SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTE 797
Query: 363 QEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQ 422
KE + R D ++E+ E G G E D P V+
Sbjct: 798 PGKEESWVSIKKFIPGRRKKRP----DGKQEQAPVEDAGPTGANEDDSDV-PAVVPLSEY 852
Query: 423 DG----KYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAE 478
D K + Q ++ E+ + T+ Q H A A +E +
Sbjct: 853 DAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPS 912
Query: 479 AFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESP 538
S P + A T+++ LE++ + E T T P E E+
Sbjct: 913 WISASVTEPLEQVEAEAALLTEEV--LEREVIAEEEPPTVTEPLPENREARGDTVVSEAE 970
Query: 539 FTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQG 598
T ++ET L +EEG +S E + SQ ++PDT +
Sbjct: 971 LTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQ-----------LTDSPDTTEEA 1019
Query: 599 TPGEKNRALEAVVPAVRGEDVQLTEDQEQPA-RGEHKNQGPGTKGPGAAVEPNGHPEAQE 657
TP ++ +E VP + ++ + E + A + + ++Q PGT GP ++P EA+
Sbjct: 1020 TPVQE---VEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE- 1075
Query: 658 STAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQG---PSSKEEKGRAT 714
R + E +G L ++ L + K + + KV G P S E+ + T
Sbjct: 1076 -------RPEEQAEASG-LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVT 1127
Query: 715 EA--QNTLLESLDEDNSASLKIQLETKE----------PVTSEEEDESP-QELAGEGGDQ 761
E+ + L+ + + A +K Q E P SE + +P + G Q
Sbjct: 1128 ESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1187
Query: 762 KSPAKKEHNSSVPWSSLEK-QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNV--TQE 818
K + H + S + + + P ER SS ++ QE+ +Q+ + T E
Sbjct: 1188 KDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVF---QEETKEQSKMEDTLE 1244
Query: 819 EHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGL 863
K+V + S +S T + + + P+ GL
Sbjct: 1245 HTDKEVSVETVS-----ILSKTEGTQEADQYADEKTKDVPFFEGL 1284
Score = 57.0 bits (136), Expect = 8e-08
Identities = 123/675 (18%), Positives = 244/675 (36%), Gaps = 77/675 (11%)
Query: 178 PKNKHLEGDEQSQEVAQD-IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGD 236
PK +E E+ +E + + T ED + ++ + K A + + +S E +
Sbjct: 316 PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE 375
Query: 237 --EPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH-SNIQEPPL 293
E E+ VS + E+ LAT E E + E H S ++E
Sbjct: 376 KVELPSEEQVSGSQGPSEEKPAPLAT------EVFDEKIEVHQEEVVAEVHVSTVEERTE 429
Query: 294 QREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDT----QEPGKDADQTPAKTKN 349
+++ E +P + ++ Q++ +K++ ++ +T ++P + AD +P + K
Sbjct: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDE-KV 488
Query: 350 LGEPEDYGRTSETQ----EKECETKDLPVQ--YGSRNGSETSDMRDERKERRGPEAHGTA 403
L +P + G SE + ++ + + P++ + S + S + + K G E G
Sbjct: 489 LSKPPE-GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEH 547
Query: 404 GQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTA 463
Q D +E +G S + E+ E L +G + + E
Sbjct: 548 TQVPAD------------SPDSQEEQKGESSASSPEEPEEITCLE-KGLAEVQQDGEAEE 594
Query: 464 VSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQP 523
+ + E +EG K +R E ++ L+K + T +
Sbjct: 595 GATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKE-DELDKVKSATLSSTESTASEM 653
Query: 524 VEEEDGYQGED-PESPFTQSDEGSSETP------NSLASEEGNSSSETGELPVQGDSQSQ 576
EE G E PE P + D S + + G+SS E G G +
Sbjct: 654 QEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK 713
Query: 577 GDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
D+ G+ + G + ++ PG+ + + E GE V E ++ K++
Sbjct: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
Query: 637 GPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSR 696
+ ++ +G + T + + I+ +PG+ R
Sbjct: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK---------------KFIPGRRKKR 818
Query: 697 NELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASL------KIQLETKEPVTSEEEDES 750
P K+E+ +A T D D A + ++ E E +++ E
Sbjct: 819 -------PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQ 871
Query: 751 PQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQ------Y 804
P++ A ++ + H + + + +E A + PL Q
Sbjct: 872 PEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL 931
Query: 805 LQEKILQQTNVTQEE 819
L E++L++ + +EE
Sbjct: 932 LTEEVLEREVIAEEE 946
Score = 53.9 bits (128), Expect = 7e-07
Identities = 130/670 (19%), Positives = 243/670 (36%), Gaps = 82/670 (12%)
Query: 94 SELRQVTKPEKEKLDDVDVQATTG--DGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGA 151
S + V + ++ L + D+ G +GQ + + +E + G S + +S
Sbjct: 63 STINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS-- 120
Query: 152 VGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQS-QEVAQDIQTTEDNEGQLKTNK 210
++ + A H+ + E + + E + +E+ Q ++ ++ G K K
Sbjct: 121 ---DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFK 177
Query: 211 PMAGSKKT--SSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEA 268
G K T TE+ + ++ + DE +D G A++ S PK++
Sbjct: 178 -FVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDP-SLGAGEAASKESEPKQS 235
Query: 269 TQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVC 328
T++P +E ++ H+ I P E + E+ + + KS +S
Sbjct: 236 TEKP---EETLKREQSHAEISPPA-----ESGQAVEECKEEGEEKQEKEPSKSAES---- 283
Query: 329 RMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMR 388
T + T K G +TS + KE E E S+ +
Sbjct: 284 ---PTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEV-------------EASEKK 327
Query: 389 DERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLS 448
E++ + + ++ T Q E + ++ + E SE Q
Sbjct: 328 KEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
Query: 449 SEGGDQTHPELEGTAVSGEEAE-HTKEGTAEAFVNSKNAPAAERTLGARER-----TQDL 502
S+G + P T V E+ E H +E AE V++ E+ E ++L
Sbjct: 388 SQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEEL 447
Query: 503 APL--EKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNS 560
+ E Q + K + V ED QG D + ++ S+ P + SE
Sbjct: 448 VEMDAEPQEAEPAKELVKLKETCVSGEDPTQGAD----LSPDEKVLSKPPEGVVSEVEML 503
Query: 561 SSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQ 620
SS+ + VQG + T + G+K + GE Q
Sbjct: 504 SSQE-RMKVQGSPLKK-------------LFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
Query: 621 L---TEDQEQPARGEHKNQGPG--------TKGPGAAVEPNGHPEAQESTAGDENRKSLE 669
+ + D ++ +GE P KG A V+ +G EA+E D +K
Sbjct: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGL-AEVQQDG--EAEEGATSDGEKKREG 606
Query: 670 IEITGALDEDFTDQLSLMQLPGKGDSRNEL-KVQGPSSKEEKGRATEAQNTLLESLDEDN 728
+ + + T + ++ P + D +EL KV+ + + A+E Q + S++E
Sbjct: 607 VTPWASFKKMVTPK-KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK 665
Query: 729 SASLKIQLET 738
K +++T
Sbjct: 666 PEEPKRKVDT 675
Score = 53.5 bits (127), Expect = 9e-07
Identities = 114/525 (21%), Positives = 197/525 (37%), Gaps = 71/525 (13%)
Query: 184 EGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQS 243
E D+ + E +D+ E EG + T ++ K T + +G + E + D+ QS
Sbjct: 1266 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTE-EAECKKDDALELQS 1324
Query: 244 VSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS-- 301
+K E+E + + +E T+ E V EK +H E + +E S
Sbjct: 1325 HAKSPPSPVEREMVVQVE----REKTE--AEPTHVNEEKLEH----ETAVTVSEEVSKQL 1374
Query: 302 -QHADLPEQAAARSPSQTQKST-----DSKDVCRMFDTQEPGKDADQTPA--KTKNLGEP 353
Q ++P A+ S + S + VC Q T A + K LGE
Sbjct: 1375 LQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGET 1434
Query: 354 EDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTR 413
+ T ET E P ++S+ ++ G +A T + K+
Sbjct: 1435 ANILETGETLE--------PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTG--PDCQAKST 1484
Query: 414 PLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTK 473
P+++ T+ +GLS + EK + ++ S E +Q + +V+ E+ E
Sbjct: 1485 PVIVSATTK-------KGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPEN 1537
Query: 474 -----EGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEED 528
E + V + A ++ + E ++ E Q+ V K Q +E
Sbjct: 1538 GILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT---QAHVIKADSQDAGQET 1594
Query: 529 GYQGEDP------ESPFTQSDEGSSETPNSLA-SEEGNSSSETGE--LPVQGDSQSQGDQ 579
+GE+P E+P T + E S T A S+ SE E + V+ + + DQ
Sbjct: 1595 EKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQ 1654
Query: 580 HGESV---------QGGHNNNPDTQRQGTPGEK-NRALEAVVPAVRGEDVQLTEDQ---- 625
E V G + P+ E+ ++L +G+DV E+Q
Sbjct: 1655 QLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSAL 1714
Query: 626 -EQPARGEHKNQGPGTKGPGAAVEPNGHP-EAQESTAGDENRKSL 668
+ A G + P T GP + + E QE E+ K++
Sbjct: 1715 ADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI 1759
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 67.4 bits (163), Expect = 6e-11
Identities = 155/765 (20%), Positives = 275/765 (35%), Gaps = 84/765 (10%)
Query: 129 QEKRMLPSGMASSSQLIPEESGAVGNNR-----VDPWREAKTHNFPGEASEHNDPKNKHL 183
+E L G+A Q E GA + V PW K P + +K
Sbjct: 476 EEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKE- 534
Query: 184 EGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQ-DKEISQEGDEPAREQ 242
DE + + + +TE +++ + M GS + P E K + D +S E
Sbjct: 535 --DELDKVKSATLSSTESTASEMQ--EEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSS 590
Query: 243 SVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQ 302
R ++EG ++A + +D+E T+ + + P Q
Sbjct: 591 KKRARRGSSSDEEGGPKAMGGDHQKADEAG-KDKETGTDGILAGSQEHDP--------GQ 641
Query: 303 HADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSET 362
+ PEQA SP++ + + + R+ ++ K + ++ G ++
Sbjct: 642 GSSSPEQAG--SPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTE 699
Query: 363 QEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQ 422
KE + R D ++E+ E G G E D P V+
Sbjct: 700 PGKEESWVSIKKFIPGRRKKRP----DGKQEQAPVEDAGPTGANEDDSDV-PAVVPLSEY 754
Query: 423 DG----KYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAE 478
D K + Q ++ E+ + T+ Q H A A +E +
Sbjct: 755 DAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPS 814
Query: 479 AFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESP 538
S P + A T+++ LE++ + E T T P E E+
Sbjct: 815 WISASVTEPLEQVEAEAALLTEEV--LEREVIAEEEPPTVTEPLPENREARGDTVVSEAE 872
Query: 539 FTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQG 598
T ++ET L +EEG +S E + SQ ++PDT +
Sbjct: 873 LTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQ-----------LTDSPDTTEEA 921
Query: 599 TPGEKNRALEAVVPAVRGEDVQLTEDQEQPA-RGEHKNQGPGTKGPGAAVEPNGHPEAQE 657
TP ++ +E VP + ++ + E + A + + ++Q PGT GP ++P EA+
Sbjct: 922 TPVQE---VEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE- 977
Query: 658 STAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQG---PSSKEEKGRAT 714
R + E +G L ++ L + K + + KV G P S E+ + T
Sbjct: 978 -------RPEEQAEASG-LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVT 1029
Query: 715 EA--QNTLLESLDEDNSASLKIQLETKE----------PVTSEEEDESP-QELAGEGGDQ 761
E+ + L+ + + A +K Q E P SE + +P + G Q
Sbjct: 1030 ESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1089
Query: 762 KSPAKKEHNSSVPWSSLEK-QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNV--TQE 818
K + H + S + + + P ER SS ++ QE+ +Q+ + T E
Sbjct: 1090 KDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVF---QEETKEQSKMEDTLE 1146
Query: 819 EHQKQVQIAQASGPELCSVSLTSEISDCSVFFNYSQASQPYTRGL 863
K+V + S +S T + + + P+ GL
Sbjct: 1147 HTDKEVSVETVS-----ILSKTEGTQEADQYADEKTKDVPFFEGL 1186
Score = 57.0 bits (136), Expect = 8e-08
Identities = 123/675 (18%), Positives = 244/675 (36%), Gaps = 77/675 (11%)
Query: 178 PKNKHLEGDEQSQEVAQD-IQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGD 236
PK +E E+ +E + + T ED + ++ + K A + + +S E +
Sbjct: 218 PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE 277
Query: 237 --EPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH-SNIQEPPL 293
E E+ VS + E+ LAT E E + E H S ++E
Sbjct: 278 KVELPSEEQVSGSQGPSEEKPAPLAT------EVFDEKIEVHQEEVVAEVHVSTVEERTE 331
Query: 294 QREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDT----QEPGKDADQTPAKTKN 349
+++ E +P + ++ Q++ +K++ ++ +T ++P + AD +P + K
Sbjct: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDE-KV 390
Query: 350 LGEPEDYGRTSETQ----EKECETKDLPVQ--YGSRNGSETSDMRDERKERRGPEAHGTA 403
L +P + G SE + ++ + + P++ + S + S + + K G E G
Sbjct: 391 LSKPPE-GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEH 449
Query: 404 GQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTA 463
Q D +E +G S + E+ E L +G + + E
Sbjct: 450 TQVPAD------------SPDSQEEQKGESSASSPEEPEEITCLE-KGLAEVQQDGEAEE 496
Query: 464 VSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQP 523
+ + E +EG K +R E ++ L+K + T +
Sbjct: 497 GATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKE-DELDKVKSATLSSTESTASEM 555
Query: 524 VEEEDGYQGED-PESPFTQSDEGSSETP------NSLASEEGNSSSETGELPVQGDSQSQ 576
EE G E PE P + D S + + G+SS E G G +
Sbjct: 556 QEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK 615
Query: 577 GDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
D+ G+ + G + ++ PG+ + + E GE V E ++ K++
Sbjct: 616 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 675
Query: 637 GPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSR 696
+ ++ +G + T + + I+ +PG+ R
Sbjct: 676 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIK---------------KFIPGRRKKR 720
Query: 697 NELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASL------KIQLETKEPVTSEEEDES 750
P K+E+ +A T D D A + ++ E E +++ E
Sbjct: 721 -------PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQ 773
Query: 751 PQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQ------Y 804
P++ A ++ + H + + + +E A + PL Q
Sbjct: 774 PEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL 833
Query: 805 LQEKILQQTNVTQEE 819
L E++L++ + +EE
Sbjct: 834 LTEEVLEREVIAEEE 848
Score = 53.5 bits (127), Expect = 9e-07
Identities = 114/525 (21%), Positives = 197/525 (37%), Gaps = 71/525 (13%)
Query: 184 EGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQS 243
E D+ + E +D+ E EG + T ++ K T + +G + E + D+ QS
Sbjct: 1168 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTE-EAECKKDDALELQS 1226
Query: 244 VSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS-- 301
+K E+E + + +E T+ E V EK +H E + +E S
Sbjct: 1227 HAKSPPSPVEREMVVQVE----REKTE--AEPTHVNEEKLEH----ETAVTVSEEVSKQL 1276
Query: 302 -QHADLPEQAAARSPSQTQKST-----DSKDVCRMFDTQEPGKDADQTPA--KTKNLGEP 353
Q ++P A+ S + S + VC Q T A + K LGE
Sbjct: 1277 LQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGET 1336
Query: 354 EDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTR 413
+ T ET E P ++S+ ++ G +A T + K+
Sbjct: 1337 ANILETGETLE--------PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTG--PDCQAKST 1386
Query: 414 PLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTK 473
P+++ T+ +GLS + EK + ++ S E +Q + +V+ E+ E
Sbjct: 1387 PVIVSATTK-------KGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPEN 1439
Query: 474 -----EGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEED 528
E + V + A ++ + E ++ E Q+ V K Q +E
Sbjct: 1440 GILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT---QAHVIKADSQDAGQET 1496
Query: 529 GYQGEDP------ESPFTQSDEGSSETPNSLA-SEEGNSSSETGE--LPVQGDSQSQGDQ 579
+GE+P E+P T + E S T A S+ SE E + V+ + + DQ
Sbjct: 1497 EKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQ 1556
Query: 580 HGESV---------QGGHNNNPDTQRQGTPGEK-NRALEAVVPAVRGEDVQLTEDQ---- 625
E V G + P+ E+ ++L +G+DV E+Q
Sbjct: 1557 QLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSAL 1616
Query: 626 -EQPARGEHKNQGPGTKGPGAAVEPNGHP-EAQESTAGDENRKSL 668
+ A G + P T GP + + E QE E+ K++
Sbjct: 1617 ADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI 1661
Score = 51.6 bits (122), Expect = 3e-06
Identities = 118/589 (20%), Positives = 215/589 (36%), Gaps = 84/589 (14%)
Query: 184 EGDEQSQEVAQDIQTTEDNEGQL----KTNKPMAGSKKTSSPTERKGQDKEISQEGDEPA 239
+G E++ E+ + I ++E N +L ++ G KK K K+ E +
Sbjct: 39 DGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTV 98
Query: 240 REQSVSKIRDQ----FGEQE------GNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQ 289
+ +V K + G+ + G A++ S PK++T++P +E ++ H+ I
Sbjct: 99 QLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKP---EETLKREQSHAEIS 155
Query: 290 EPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKN 349
P E + E+ + + KS +S T + T K
Sbjct: 156 PPA-----ESGQAVEECKEEGEEKQEKEPSKSAES-------PTSPVTSETGSTFKKFFT 203
Query: 350 LGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERD 409
G +TS + KE E E S+ + E++ + + +
Sbjct: 204 QGWAGWRKKTSFRKPKEDEV-------------EASEKKKEQEPEKVDTEEDGKAEVASE 250
Query: 410 RKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEA 469
+ T Q E + ++ + E SE Q S+G + P T V E+
Sbjct: 251 KLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKI 310
Query: 470 E-HTKEGTAEAFVNSKNAPAAERTLGARER-----TQDLAPL--EKQSVGENTRVTKTHD 521
E H +E AE V++ E+ E ++L + E Q + K +
Sbjct: 311 EVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKE 370
Query: 522 QPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHG 581
V ED QG D + ++ S+ P + SE SS+ + VQG +
Sbjct: 371 TCVSGEDPTQGAD----LSPDEKVLSKPPEGVVSEVEMLSSQE-RMKVQGSPLKK----- 420
Query: 582 ESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQL---TEDQEQPARGEHKNQGP 638
T + G+K + GE Q+ + D ++ +GE P
Sbjct: 421 --------LFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSP 472
Query: 639 G--------TKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLP 690
KG A V+ +G EA+E D +K + + + T + ++ P
Sbjct: 473 EEPEEITCLEKGL-AEVQQDG--EAEEGATSDGEKKREGVTPWASFKKMVTPK-KRVRRP 528
Query: 691 GKGDSRNEL-KVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLET 738
+ D +EL KV+ + + A+E Q + S++E K +++T
Sbjct: 529 SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDT 577
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 67.4 bits (163), Expect = 6e-11
Identities = 83/361 (22%), Positives = 141/361 (39%), Gaps = 45/361 (12%)
Query: 170 GEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKP-MAGSKKTSSPTERKG-- 226
GE + + + +++ +E ++++ T E+ K KP A S SP E KG
Sbjct: 569 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 628
Query: 227 -------QDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVR 279
++K S P E+ S + E++G SP +E + P V
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 688
Query: 280 TEK------------EKHSNIQEPPLQREDEPSSQHA-DLPEQAAARSP------SQTQK 320
K E+ ++E P + + E + D+PE+ A SP ++
Sbjct: 689 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 748
Query: 321 STDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRN 380
T S V +T+E GK Q K K GE S+ K +D+ V G
Sbjct: 749 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVN-GEVE 807
Query: 381 GSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEK 440
G E ++ E KE+ G+ ++E+ T L L E +G KS++
Sbjct: 808 GKE--EVEQETKEK------GSGREEEKGVVTNGLDLSPA------DEKKGGDKSEEKVV 853
Query: 441 GSET-QYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERT 499
++T + ++SEGGD + + ++ E +E E V++K +E T
Sbjct: 854 VTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVT 913
Query: 500 Q 500
Q
Sbjct: 914 Q 914
Score = 56.6 bits (135), Expect = 1e-07
Identities = 79/381 (20%), Positives = 143/381 (37%), Gaps = 46/381 (12%)
Query: 414 PLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTK 473
P+ + ++ Q K + + + K E+ E + E + E TA++ E A K
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM---EEALTAITEELAVSMK 485
Query: 474 EGTAEAFVNSKNAPAAERTLGARERT--QDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQ 531
E EA + P AE A +++ + AP K+ GE EEE+G +
Sbjct: 486 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK-----------EEEEGQE 534
Query: 532 GEDPESPFTQSD---EGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGH 588
E+ E +SD EG SE S EEG E +G+ ++ +
Sbjct: 535 EEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
Query: 589 NNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVE 648
+ EK ++ VP E+ + + P E K + P K P VE
Sbjct: 595 VATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV--EEKGKSPVPKSP---VE 649
Query: 649 PNGHPEAQESTAGDE-----NRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNE----- 698
G +S ++ ++ +E + + + ++ GKG+ + E
Sbjct: 650 EKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEV 709
Query: 699 ----------LKVQGPSSKEEKGRATEA--QNTLLESLDEDNSASLKIQLETKEPVTSEE 746
K + P EK +A + + E + S + ++ ETKE +
Sbjct: 710 KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 769
Query: 747 EDESPQELAGEGGDQKSPAKK 767
+++ ++ GEGG ++ + K
Sbjct: 770 QEKEKEKAGGEGGSEEEGSDK 790
Score = 53.1 bits (126), Expect = 1e-06
Identities = 87/440 (19%), Positives = 175/440 (39%), Gaps = 56/440 (12%)
Query: 231 ISQEGDEPAREQSVSKIRDQFGEQ---EGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
IS + +P E K++ +F E+ E + + S +EA E+ V ++EK
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 491
Query: 288 IQEPPLQREDEPSSQHADL-----PEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQ 342
+E +E+EP ++ ++ P +A A + + + ++ + ++ G +DQ
Sbjct: 492 AEE----KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 547
Query: 343 TP--------AKTKNLGEPEDYGRTSETQEKECETKD-LPVQYGSRNGSETSDMRDERKE 393
+ K GE E+ +E + +E E K+ V+ S + ++ + K
Sbjct: 548 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKV 607
Query: 394 RRGPEAHGTAGQKERDRKTRPLVLETQTQD-GKYQ------ELQGLS---KSKDAEKGSE 443
+ +A + + K + V ++ ++ GK E +G S KS EKG
Sbjct: 608 EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 667
Query: 444 TQYLSSEGGDQTHP---------ELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLG 494
S P + + GE+ E ++ EA K E+
Sbjct: 668 PVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 727
Query: 495 ARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLA 554
E+ + +P+++++V E +TK+ +E+E +G+ P Q E A
Sbjct: 728 VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK----PLQQEKE------KEKA 777
Query: 555 SEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAV 614
EG S E + +G + +GE V+G +T+ +G+ E+ + +
Sbjct: 778 GGEGGSEEEGSDKGAKGSRKEDIAVNGE-VEGKEEVEQETKEKGSGREEEKGV-----VT 831
Query: 615 RGEDVQLTEDQEQPARGEHK 634
G D+ ++++ + E K
Sbjct: 832 NGLDLSPADEKKGGDKSEEK 851
Score = 46.2 bits (108), Expect = 1e-04
Identities = 76/388 (19%), Positives = 145/388 (37%), Gaps = 49/388 (12%)
Query: 179 KNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEG--- 235
+ K +E+ +E + + + +K P ++ E +++E EG
Sbjct: 486 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 545
Query: 236 ---DEPAREQSVSKIRDQFGEQEGNLATQS----SPPKEATQRPCEDQEVRTEKE--KHS 286
+E E+ S +++ ++EG ++ + KE + + +EV T++E +
Sbjct: 546 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA 605
Query: 287 NIQEPPLQREDEPSSQHADLPEQAAARSP------SQTQKS---TDSKDVCRMFDTQEPG 337
+++P + P S + + +SP S KS K +E G
Sbjct: 606 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 665
Query: 338 KD-ADQTPAKTK-----------NLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETS 385
K ++P + K + G+ + +E+E E K+ P + E
Sbjct: 666 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725
Query: 386 DMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQ 445
E+K+ P + K+ + LE +T+ +E + L + K+ EK
Sbjct: 726 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK----EEGKPLQQEKEKEKAGGEG 781
Query: 446 YLSSEGGDQ--THPELEGTAVSGEEAEHTKEGTAEAFVNSK-NAPAAERTLGARERTQDL 502
EG D+ E AV+GE EG E +K E G DL
Sbjct: 782 GSEEEGSDKGAKGSRKEDIAVNGE-----VEGKEEVEQETKEKGSGREEEKGVVTNGLDL 836
Query: 503 APLEKQSVGENTR----VTKTHDQPVEE 526
+P +++ G+ + VTKT ++ E
Sbjct: 837 SPADEKKGGDKSEEKVVVTKTVEKITSE 864
Score = 44.3 bits (103), Expect = 5e-04
Identities = 124/677 (18%), Positives = 243/677 (35%), Gaps = 112/677 (16%)
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEG-----DEPAR 240
++Q++E+ +IQ Q + + G E + + ++ E D
Sbjct: 123 EQQNKEIEAEIQALR----QKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHL 178
Query: 241 EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQE-VRTEKEKH-SNIQEPPLQREDE 298
E+ + +++++F E+E L + A ++ E+ V+ E +K ++Q+
Sbjct: 179 EEDIHRLKERF-EEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSN 237
Query: 299 PSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPED--- 355
+ ADL Q A + +K D+ ++ +N+ + E+
Sbjct: 238 HEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSD----QNMHQAEEWFK 293
Query: 356 --YGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTR 413
Y + +E E+ E R+ E + + + E G KE
Sbjct: 294 CRYAKLTEAAEQNKEA--------IRSAKEEIAEYRRQLQSKSIELESVRGTKES----- 340
Query: 414 PLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTK 473
LE Q D + + LS +D + Q EL GT E A H +
Sbjct: 341 ---LERQLSDIEERHNHDLSSYQDTIQ-------------QLENELRGT--KWEMARHLR 382
Query: 474 EGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTK----------THDQP 523
E + +N K A E +A K GE TR + TH P
Sbjct: 383 E--YQDLLNVKMALDIE-----------IAAYRKLLEGEETRFSTFAGSITGPLYTHRPP 429
Query: 524 VEEEDGYQGEDPESP-------FTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQ 576
+ Q E+P F + ++ + + E ++ T EL V S
Sbjct: 430 ITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAV-----SM 484
Query: 577 GDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQ 636
++ E+ + P+ + + +K+ ++A P V+ E+ + E++ Q E
Sbjct: 485 KEEKKEAAEE-KEEEPEAEEEEVAAKKS-PVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 637 GPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSR 696
+ E G E +E G++ E E G + + ++ + + + ++
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEE---GEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATK 598
Query: 697 NELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAG 756
EL K EK ++ ++ + E + K PV +SP E G
Sbjct: 599 EELVADAKVEKPEKAKSPVPKSPVEE--------------KGKSPVP-----KSPVEEKG 639
Query: 757 EGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVT 816
+ KSP +++ S VP S +E++ + VE A P + K +
Sbjct: 640 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKG 699
Query: 817 QEEHQKQVQIAQASGPE 833
+++ +++ ++ +A E
Sbjct: 700 EQKEEEEKEVKEAPKEE 716
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 67.4 bits (163), Expect = 6e-11
Identities = 83/361 (22%), Positives = 141/361 (39%), Gaps = 45/361 (12%)
Query: 170 GEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKP-MAGSKKTSSPTERKG-- 226
GE + + + +++ +E ++++ T E+ K KP A S SP E KG
Sbjct: 193 GETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
Query: 227 -------QDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVR 279
++K S P E+ S + E++G SP +E + P V
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 280 TEK------------EKHSNIQEPPLQREDEPSSQHA-DLPEQAAARSP------SQTQK 320
K E+ ++E P + + E + D+PE+ A SP ++
Sbjct: 313 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 372
Query: 321 STDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRN 380
T S V +T+E GK Q K K GE S+ K +D+ V G
Sbjct: 373 ITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVN-GEVE 431
Query: 381 GSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEK 440
G E ++ E KE+ G+ ++E+ T L L E +G KS++
Sbjct: 432 GKE--EVEQETKEK------GSGREEEKGVVTNGLDLSPA------DEKKGGDKSEEKVV 477
Query: 441 GSET-QYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERT 499
++T + ++SEGGD + + ++ E +E E V++K +E T
Sbjct: 478 VTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVT 537
Query: 500 Q 500
Q
Sbjct: 538 Q 538
Score = 56.6 bits (135), Expect = 1e-07
Identities = 79/381 (20%), Positives = 143/381 (37%), Gaps = 46/381 (12%)
Query: 414 PLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTK 473
P+ + ++ Q K + + + K E+ E + E + E TA++ E A K
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM---EEALTAITEELAVSMK 109
Query: 474 EGTAEAFVNSKNAPAAERTLGARERT--QDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQ 531
E EA + P AE A +++ + AP K+ GE EEE+G +
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK-----------EEEEGQE 158
Query: 532 GEDPESPFTQSD---EGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGH 588
E+ E +SD EG SE S EEG E +G+ ++ +
Sbjct: 159 EEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEE 218
Query: 589 NNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVE 648
+ EK ++ VP E+ + + P E K + P K P VE
Sbjct: 219 VATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV--EEKGKSPVPKSP---VE 273
Query: 649 PNGHPEAQESTAGDE-----NRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNE----- 698
G +S ++ ++ +E + + + ++ GKG+ + E
Sbjct: 274 EKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEV 333
Query: 699 ----------LKVQGPSSKEEKGRATEA--QNTLLESLDEDNSASLKIQLETKEPVTSEE 746
K + P EK +A + + E + S + ++ ETKE +
Sbjct: 334 KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 393
Query: 747 EDESPQELAGEGGDQKSPAKK 767
+++ ++ GEGG ++ + K
Sbjct: 394 QEKEKEKAGGEGGSEEEGSDK 414
Score = 53.1 bits (126), Expect = 1e-06
Identities = 87/440 (19%), Positives = 175/440 (39%), Gaps = 56/440 (12%)
Query: 231 ISQEGDEPAREQSVSKIRDQFGEQ---EGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
IS + +P E K++ +F E+ E + + S +EA E+ V ++EK
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115
Query: 288 IQEPPLQREDEPSSQHADL-----PEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQ 342
+E +E+EP ++ ++ P +A A + + + ++ + ++ G +DQ
Sbjct: 116 AEE----KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
Query: 343 TP--------AKTKNLGEPEDYGRTSETQEKECETKD-LPVQYGSRNGSETSDMRDERKE 393
+ K GE E+ +E + +E E K+ V+ S + ++ + K
Sbjct: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKV 231
Query: 394 RRGPEAHGTAGQKERDRKTRPLVLETQTQD-GKYQ------ELQGLS---KSKDAEKGSE 443
+ +A + + K + V ++ ++ GK E +G S KS EKG
Sbjct: 232 EKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKS 291
Query: 444 TQYLSSEGGDQTHP---------ELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLG 494
S P + + GE+ E ++ EA K E+
Sbjct: 292 PVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351
Query: 495 ARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLA 554
E+ + +P+++++V E +TK+ +E+E +G+ P Q E A
Sbjct: 352 VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK----PLQQEKE------KEKA 401
Query: 555 SEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAV 614
EG S E + +G + +GE V+G +T+ +G+ E+ + +
Sbjct: 402 GGEGGSEEEGSDKGAKGSRKEDIAVNGE-VEGKEEVEQETKEKGSGREEEKGV-----VT 455
Query: 615 RGEDVQLTEDQEQPARGEHK 634
G D+ ++++ + E K
Sbjct: 456 NGLDLSPADEKKGGDKSEEK 475
Score = 46.2 bits (108), Expect = 1e-04
Identities = 76/388 (19%), Positives = 145/388 (37%), Gaps = 49/388 (12%)
Query: 179 KNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEG--- 235
+ K +E+ +E + + + +K P ++ E +++E EG
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
Query: 236 ---DEPAREQSVSKIRDQFGEQEGNLATQS----SPPKEATQRPCEDQEVRTEKE--KHS 286
+E E+ S +++ ++EG ++ + KE + + +EV T++E +
Sbjct: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA 229
Query: 287 NIQEPPLQREDEPSSQHADLPEQAAARSP------SQTQKS---TDSKDVCRMFDTQEPG 337
+++P + P S + + +SP S KS K +E G
Sbjct: 230 KVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKG 289
Query: 338 KD-ADQTPAKTK-----------NLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETS 385
K ++P + K + G+ + +E+E E K+ P + E
Sbjct: 290 KSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
Query: 386 DMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQ 445
E+K+ P + K+ + LE +T+ +E + L + K+ EK
Sbjct: 350 KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK----EEGKPLQQEKEKEKAGGEG 405
Query: 446 YLSSEGGDQ--THPELEGTAVSGEEAEHTKEGTAEAFVNSK-NAPAAERTLGARERTQDL 502
EG D+ E AV+GE EG E +K E G DL
Sbjct: 406 GSEEEGSDKGAKGSRKEDIAVNGE-----VEGKEEVEQETKEKGSGREEEKGVVTNGLDL 460
Query: 503 APLEKQSVGENTR----VTKTHDQPVEE 526
+P +++ G+ + VTKT ++ E
Sbjct: 461 SPADEKKGGDKSEEKVVVTKTVEKITSE 488
Score = 41.2 bits (95), Expect = 0.004
Identities = 55/264 (20%), Positives = 107/264 (40%), Gaps = 29/264 (10%)
Query: 593 DTQRQGTPGEKNRALEAVVP----AVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVE 648
+T+ + E AL A+ +++ E + E++E+ E + K P A
Sbjct: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATA 141
Query: 649 PNGHPEA---------QESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNEL 699
P E +E DE KS + E G+ E +++ Q +G++ E
Sbjct: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQ--EEGETEAEA 199
Query: 700 KVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQL--ETKEPVTSEEEDE-------- 749
+ + +KEEK +++ + E+ A K++ + K PV +E
Sbjct: 200 EGEEAEAKEEKKVEEKSEEVATK---EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 256
Query: 750 SPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKI 809
SP E G+ KSP +++ S VP S +E++ + VE A P + K
Sbjct: 257 SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 316
Query: 810 LQQTNVTQEEHQKQVQIAQASGPE 833
+ +++ +++ ++ +A E
Sbjct: 317 KAEVGKGEQKEEEEKEVKEAPKEE 340
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 65.9 bits (159), Expect = 2e-10
Identities = 61/297 (20%), Positives = 126/297 (42%), Gaps = 12/297 (4%)
Query: 187 EQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSK 246
EQ +V + + EGQ++ + ++ E++GQ +E QEG +E V +
Sbjct: 133 EQEGQVREQEGQVREQEGQVREQEGQVREQE-GQVREQEGQVRE--QEGQVREQEGQVRE 189
Query: 247 IRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADL 306
Q GEQEG + Q E ++ + +E E+E+ QE + ++E + +
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 307 PEQAAARSPSQTQKSTDSKDVCR-----MFDTQEPGKDADQTPAKTKNLGEPEDYGRTSE 361
++ + Q ++ + ++ R M +E + +QT + + + E E+ R E
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE 309
Query: 362 TQ--EKECETKDLPVQYGSRNGS--ETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVL 417
Q E+E + ++ Q G + E + E+KE+ + Q+E+ +K V
Sbjct: 310 EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 418 ETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKE 474
+ + Q K +E + + ++ + + G+Q E GE+ E ++
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/294 (21%), Positives = 128/294 (43%), Gaps = 16/294 (5%)
Query: 187 EQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSK 246
EQ +V + + EGQ++ + ++ E++GQ +E QEG +E V +
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQE-GQVREQEGQVRE--QEGQVREQEGQVRE 182
Query: 247 IRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADL 306
Q EQEG + Q E ++ E +E ++E+ QE +++++E +
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ--- 239
Query: 307 PEQAAARSPSQTQKSTDS--KDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQE 364
E+ + Q QK + K +M + +E ++ ++ K K E E+ +T E +E
Sbjct: 240 -EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE--QTGEQEE 296
Query: 365 KECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDG 424
+ E ++ + + + MR E++E+ G + QKE+ + + + + + Q G
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMR-EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355
Query: 425 KYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAE 478
+ +E + K ++ + E Q E +Q + E E+ KE E
Sbjct: 356 EQEE--QMQKQEEQVRKQEEQMRKQE--EQMRKQEEQMRKQEEQMGEQKEQMGE 405
Score = 53.1 bits (126), Expect = 1e-06
Identities = 84/423 (19%), Positives = 168/423 (39%), Gaps = 37/423 (8%)
Query: 178 PKNKHLEGDEQSQEVAQDIQTTEDNEGQ-----------LKTNK---PMAGSKKTSSPTE 223
P+ + E E++ E+ +++Q E + + L+T+K P G +
Sbjct: 2 PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 224 RKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKE 283
R+ + + QEG +E V + Q EQEG + Q +E + E + E+E
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 284 KHSNIQEPPL-QREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFD--TQEPGKDA 340
QE + ++E + Q + EQ + Q V ++ G+
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 341 DQTPAKTKNLGE-PEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEA 399
+Q + G+ E G+ E +E+ E ++ + + G + MR +++E+ G +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR-KQEEQMGEQE 240
Query: 400 HGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPEL 459
Q+E+ +K Q + + QE Q + + ++ + E Q L + +QT E
Sbjct: 241 EQVQKQEEQVQK--------QEEQMRKQEEQ-MREQEEQMREQEEQMLKQK--EQTEQEE 289
Query: 460 EGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKT 519
+ +GE+ E +E E + + E+ RE+ + + E+Q + ++ +
Sbjct: 290 Q----TGEQEEQMRE--QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ 343
Query: 520 HDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQ 579
+Q ++E+ GE E Q ++ + EE E + Q +Q
Sbjct: 344 KEQMWKQEE-QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQ 402
Query: 580 HGE 582
GE
Sbjct: 403 MGE 405
Score = 50.4 bits (119), Expect = 7e-06
Identities = 79/428 (18%), Positives = 157/428 (36%), Gaps = 41/428 (9%)
Query: 364 EKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQD 423
+++ ET +P+ + + +R++ + R E +E++ + R + + Q+
Sbjct: 38 KRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQ----VREQEGQVREQEGQVREQE 93
Query: 424 GKYQELQGLSKSKDAE-KGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVN 482
G+ +E +G + ++ + + E Q EG + E EG E +EG V
Sbjct: 94 GQVREQEGQVREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQVREQEGQ----VR 146
Query: 483 SKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQS 542
+ E+ RE+ + E Q V E + + V E++G GE E +
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQMGEQ-EGQMGEQ 204
Query: 543 DEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGE 602
+E E + +E + ++ + Q +Q GE + Q+Q
Sbjct: 205 EEQMGEQEEQMQKQEEQMGEQEEQM------RKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258
Query: 603 KNRALEAVVPAVRGEDVQLTEDQEQPARGE---HKNQGPGTKGPGAAVEPNGHPEAQEST 659
K +R ++ Q+ E +EQ + + + + G + + E +E
Sbjct: 259 KQEE------QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQM 312
Query: 660 AGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNT 719
E + + E G +E +Q M E K Q +E+ G E
Sbjct: 313 REQEEQMREQEEQMGKQEEQMWEQKEQMW---------EQKEQMWKQEEQMGEQEEQMQK 363
Query: 720 LLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLE 779
E + + K + + ++ EE+ +E GE +Q K++ +
Sbjct: 364 QEEQVRKQEEQMRKQEEQMRK---QEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQ 420
Query: 780 KQMQRDQE 787
K+ R QE
Sbjct: 421 KEQMRKQE 428
Score = 49.3 bits (116), Expect = 2e-05
Identities = 62/345 (17%), Positives = 129/345 (37%), Gaps = 23/345 (6%)
Query: 292 PLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQE-PGKDADQTPAKTKNL 350
P +E ++A+L E+ +++ K++ R +T + P Q + +
Sbjct: 2 PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 351 GEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDR 410
E E R E Q +E E + + + +E+ G +E++
Sbjct: 62 REQEGQVREQEGQVREQE-------------GQVREQEGQVREQEGQVREQEGQVREQEG 108
Query: 411 KTRPLVLETQTQDGKYQELQGLSKSKDAE-KGSETQYLSSEGGDQTHPELEGTAVSGEEA 469
+ R + + Q+G+ +E +G + ++ + + E Q EG + E EG E
Sbjct: 109 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQ 165
Query: 470 EHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDG 529
+EG V + E+ RE+ + E Q +GE ++ +++++
Sbjct: 166 VREQEGQ----VREQEGQVREQEGQVREQEGQMGEQEGQ-MGEQEEQMGEQEEQMQKQEE 220
Query: 530 YQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHN 589
GE E Q ++ + EE E + + Q +Q E +
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK 280
Query: 590 NNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHK 634
T+++ GE+ + +R ++ Q+ E +EQ E +
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQ 325
Score = 48.1 bits (113), Expect = 4e-05
Identities = 61/337 (18%), Positives = 132/337 (39%), Gaps = 13/337 (3%)
Query: 496 RERTQDLAPLEKQS-VGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLA 554
R+ D PL ++ V E + + V E++G Q + E + + E +
Sbjct: 39 RKLETDKIPLPQEGQVREQEGQVREQEGQVREQEG-QVREQEGQVREQEGQVREQEGQVR 97
Query: 555 SEEGNSSSETGELPVQGDS--QSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVP 612
+EG + G++ Q + +G + Q +++G E+ +
Sbjct: 98 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 157
Query: 613 AVRGEDVQLTEDQEQPARGE---HKNQGPGTKGPGAAVEPNGHPEAQESTAGD-ENRKSL 668
VR ++ Q+ E + Q E + +G + G E G QE G+ E +
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK 217
Query: 669 EIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDN 728
+ E G +E Q M + + E +VQ +E+ + E E + E
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ--KQEEQMRKQEEQMREQEEQMREQE 275
Query: 729 SASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEP 788
LK + +T++ + E++E +E + +Q+ +++ E+QM + +E
Sbjct: 276 EQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM---REQEEQMGKQEEQ 332
Query: 789 CSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQ 825
++ ++ + QE+ + + ++ ++QV+
Sbjct: 333 MWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Score = 43.9 bits (102), Expect = 7e-04
Identities = 39/226 (17%), Positives = 100/226 (44%), Gaps = 8/226 (3%)
Query: 170 GEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTER--KGQ 227
GE E + + + G+++ Q Q+ Q E E K + + ++ E + Q
Sbjct: 209 GEQEEQMQKQEEQM-GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267
Query: 228 DKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
++++ ++ ++ +++ ++ +Q GEQE + Q +E ++ E +E E+E+
Sbjct: 268 EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMG 327
Query: 288 IQEPPL-QREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAK 346
QE + +++++ Q + +Q + Q + V + ++ K +Q +
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRK--QEEQMRKQEEQMRKQ 385
Query: 347 TKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERK 392
+ + + E+ + E +E+ E K+ + + G + MR + +
Sbjct: 386 EEQMRKQEE--QMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 42.7 bits (99), Expect = 0.002
Identities = 52/263 (19%), Positives = 105/263 (39%), Gaps = 31/263 (11%)
Query: 161 REAKTHNFPGEASEHNDPKNKHLE--GDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKT 218
+E + G+ E + E G+++ Q Q+ Q E E K + M ++
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 219 SSPTERKGQDKEIS--------QEGDEPAREQSVSKIRD-QFGEQEGNLATQSSPPKEAT 269
E + Q +E +E +E REQ ++ + EQE Q +E
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 270 QRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCR 329
++ E +E E+E+ QE + +++E + Q ++ + K+ +
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWE--------------QKEQMWEQKE--Q 346
Query: 330 MFDTQEP-GKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMR 388
M+ +E G+ +Q + + + + E+ R E Q ++ E + ++ E +
Sbjct: 347 MWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ---MRKQEEQMGEQKEQM 403
Query: 389 DERKERRGPEAHGTAGQKERDRK 411
E+KE+ + QKE+ RK
Sbjct: 404 GEQKEQMREQEEQMGEQKEQMRK 426
Score = 38.1 bits (87), Expect = 0.037
Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 3/109 (2%)
Query: 185 GDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTE---RKGQDKEISQEGDEPARE 241
G ++ Q Q Q E E K + M ++ E RK +++ QE +E
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQE 386
Query: 242 QSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQE 290
+ + K +Q GEQ+ + Q +E ++ E +E ++E+H Q+
Sbjct: 387 EQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 37.4 bits (85), Expect = 0.064
Identities = 50/273 (18%), Positives = 110/273 (40%), Gaps = 24/273 (8%)
Query: 563 ETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQ---RQGTPGEKNRALEAVVPAVRGEDV 619
ET ++P+ + Q + + Q G + Q ++G E+ + VR ++
Sbjct: 42 ETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 101
Query: 620 QLTEDQEQPARGE---HKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGAL 676
Q+ E + Q E + +G + G E G QE ++ + E E G +
Sbjct: 102 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE--GQV 159
Query: 677 DEDFTDQLSLMQLPGK-GDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQ 735
E + + + G+ + +++ Q +E++G+ E + + E ++ ++Q
Sbjct: 160 REQ---EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ 216
Query: 736 LETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGA 795
+ ++ EE+ +E GE +Q +++ +++ R+QE E+
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ-- 274
Query: 796 VYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQ 828
+E++L+Q T++E Q Q Q
Sbjct: 275 ----------EEQMLKQKEQTEQEEQTGEQEEQ 297
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 63.5 bits (153), Expect = 8e-10
Identities = 131/654 (20%), Positives = 253/654 (38%), Gaps = 85/654 (12%)
Query: 187 EQSQEVAQDIQTTEDNEGQLKTN---KPMAGSKKTSSPTER--KGQDKEISQEGDEPARE 241
E +++ A D++ E +K KP ++ P + K +DK ++ ++P +E
Sbjct: 619 EVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKE 678
Query: 242 QSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS 301
+ +++ + ++E PK+ ++ +EV+ E +K ++ + E EP
Sbjct: 679 EVKKEVKKEIKKEE------KKEPKKEVKKETPPKEVKKEVKKEE--KKEVKKEEKEPKK 730
Query: 302 QHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNL-------GEPE 354
+ LP+ A K + + ++P + P K +++ G+P+
Sbjct: 731 EIKKLPKDA-------------KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPK 777
Query: 355 DYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRK--T 412
+ G+ +++ + + G+ G+ T+ + G A G A + E +R +
Sbjct: 778 EKGKIKVIKKEGKAAEAVAAAVGT--GATTAAVM----AAAGIAAIGPAKELEAERSLMS 831
Query: 413 RPLVLETQTQDGKYQELQ-------GLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVS 465
P L ++ K +E+ L +D EK ET+ + + + +G A S
Sbjct: 832 SPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES 891
Query: 466 GEEAEHTKEGTAEAFVNSKNA-PAAERTLGARERTQDLAP--LEKQSVGENTRVTKTHDQ 522
+E T EG E + P ++ + E+ +D E G+ +T +
Sbjct: 892 PDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEA 951
Query: 523 PVEEEDGYQG-----------EDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQG 571
EEDG + ED ES ++D E S+AS + + + E +G
Sbjct: 952 EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKG 1011
Query: 572 DSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARG 631
+++ ++ E + D + + EK A E V AV + + +EQ
Sbjct: 1012 EAEQSEEEADEE-----DKAEDAREEEYEPEKMEA-EDYVMAVVDKAAEAGGAEEQYGFL 1065
Query: 632 EHKNQGPGTKGPGAAVEPNGHPEA------QESTAGDE-NRKSLEIEITGALDEDFTDQL 684
+ G + PG + H E E+TA DE NR+ E T +T
Sbjct: 1066 TTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTAT--SGYTQ-- 1121
Query: 685 SLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTS 744
S +++ + +E+ +E T + T S + N + L ++E S
Sbjct: 1122 STIEISSEPTPMDEMSTPRDVMSDE----TNNEETESPSQEFVNITKYESSLYSQE--YS 1175
Query: 745 EEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQRDQEPCSVERGAVYS 798
+ D +P EG + K++N+S S M+ D+ S R A S
Sbjct: 1176 KPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCS 1229
Score = 54.7 bits (130), Expect = 4e-07
Identities = 145/728 (19%), Positives = 270/728 (37%), Gaps = 123/728 (16%)
Query: 120 QWTVGTSPTQEKRMLPSGMASSSQL--IPEESGAVGNNRVDPWREAKTHNFPGEASEHND 177
QWT GT+ + + +LP+G + + S + + +P + FPG ++++N
Sbjct: 440 QWT-GTNKDKAEFILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNI 498
Query: 178 PKNKHLEGDEQSQEV---AQDIQTTEDNEGQLKTN-------KPMAGSKKTSSPTERKGQ 227
LEG E+ + + Q + T +D GQ+ T K A S+++ P +
Sbjct: 499 -----LEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLP 553
Query: 228 DKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
K + +E E E V+K+ PPK ++ ++V +K+K
Sbjct: 554 SKSVRKESKEETPE--VTKVNHV-----------EKPPKVESK-----EKVMVKKDK--- 592
Query: 288 IQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKT 347
P++ E +PS ++P S+ + S +V T K A + K
Sbjct: 593 ----PIKTETKPSVTEKEVP--------SKEEPSPVKAEVAEKQATDVKPKAAKEKTVKK 640
Query: 348 KNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKE 407
+ +PED E +KE K+ + +++ E K+ E +KE
Sbjct: 641 ETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKE-EKKEPKKE 699
Query: 408 RDRKTRPLVLETQTQDGKYQELQGLSKS---------KDAEKGS-------ETQYLSSEG 451
++T P ++ + + + +E++ K KDA+K S + L +
Sbjct: 700 VKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKV 759
Query: 452 GDQTHPELEGTAVSGEEAEH------TKEG-TAEAFVNSKNAPAAERTLGARERTQDLAP 504
+ + + +G+ E KEG AEA + A + A + P
Sbjct: 760 PKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGP 819
Query: 505 -----LEKQSVGENTRVTKTHDQ-PVEEEDGYQGEDPESPFTQSDEGSSETPNSLA---S 555
E+ + +TK ++ EE D + P+ + +E ET A
Sbjct: 820 AKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQ 879
Query: 556 EEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPG-----EKNRALEAV 610
+E + E P +G + ++G+ GE Q P ++QG ++ E
Sbjct: 880 KEREVTKGPAESPDEGITTTEGE--GECEQTPEELEP-VEKQGVDDIEKFEDEGAGFEES 936
Query: 611 VPAVRGEDVQLTEDQEQPARG--EH-----KNQGPGTKGPGAAVEPNGH-PEAQESTAGD 662
E+ TE+ E+P EH P A E + + E +ES A
Sbjct: 937 SETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASG 996
Query: 663 ENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLE 722
++R +ED + + KG++ + K E R E + +E
Sbjct: 997 DDR----------AEEDMDEAIE------KGEAEQSEEEADEEDKAEDAREEEYEPEKME 1040
Query: 723 SLDEDNSASLKIQLETKEPVTSEEED---ESPQELAGEGGDQKSPAKKEHNSSVPWSSLE 779
+ D + + + E +EE+ +P + G + PA H+ ++P S
Sbjct: 1041 AED----YVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSES 1096
Query: 780 KQMQRDQE 787
+ D+E
Sbjct: 1097 EATASDEE 1104
>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
sapiens]
Length = 1393
Score = 63.2 bits (152), Expect = 1e-09
Identities = 156/700 (22%), Positives = 232/700 (33%), Gaps = 123/700 (17%)
Query: 127 PTQEKRMLP--SGMASSSQLIP---EESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNK 181
PT+ + P + +SS P EE + N P T N A+E+ P
Sbjct: 580 PTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 639
Query: 182 HLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTE--RKGQDKEISQEGDEPA 239
G +++E+ + +TT + + A K TSSP E GQ + E
Sbjct: 640 ---GPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANE----- 691
Query: 240 REQSVSKIRDQFGEQE--GNLATQSSP--PKEATQR---------PCEDQEVRTEKEKHS 286
+ S S + GE+ N T SP P E +R P E E R +
Sbjct: 692 KTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANEN 751
Query: 287 NIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAK 346
P E+ + A+ + P++ K T + + EP + A++TP
Sbjct: 752 TTPSPAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLA 811
Query: 347 TKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSE-TSDMRDERKERRGPEAHGTAGQ 405
+N TS E P + R +E T+ E E R +
Sbjct: 812 NEN--------TTSSPAE--------PTENRERTANEKTTQFPAEPTENR---------E 846
Query: 406 KERDRKTRPLVLE-TQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAV 464
+ KT P E T+ ++ E LS ++ E T + E T +
Sbjct: 847 STANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLAN-----------EKTTL 895
Query: 465 SGEEAEHTKEGTAEAFVNSKNAPAA-------ERTLGARERT--QDLAPLEKQSVGENTR 515
S AE T+ G F N K P++ ERT A E T P E N +
Sbjct: 896 S--PAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAEPTEHGERIANEK 953
Query: 516 VTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETP--NSLASEEGNSSSETGELPVQ--- 570
T + +P E + ED + E TP N + S+E GE
Sbjct: 954 ATPSPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTESTEHGERTANEKT 1013
Query: 571 GDSQSQGDQHGESVQGGHNN------NPDTQRQGTP-GEKNRALEAVVPAVRGEDVQLTE 623
S ++ +HGE + P + TP +N V P GE L
Sbjct: 1014 TPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLAN 1073
Query: 624 DQ-----EQPARGEHKNQGPGTKGPGAAVEPNGHPE------------AQESTAGDENRK 666
++ E P K K + +P H E A EST +
Sbjct: 1074 EKITLSPEGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDKITSSAAESTEHRDRAT 1133
Query: 667 SLEI------------EITGALDEDFTDQL-SLMQLPGKGDSRNELKVQGPSSK---EEK 710
S + + T E T + P K S E + P EK
Sbjct: 1134 SANVITPAPAEPIKHAKRTTLAHEKMTQVTEKSTEHPEKTTSTTEKTTRTPEKPTLYSEK 1193
Query: 711 GRATEAQNTLLESLDEDNSASLKIQLET-KEPVTSEEEDE 749
T+ +NT + +N + + ET K PV S E E
Sbjct: 1194 TICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTENPE 1233
Score = 62.4 bits (150), Expect = 2e-09
Identities = 147/704 (20%), Positives = 238/704 (33%), Gaps = 119/704 (16%)
Query: 94 SELRQVTKPEKEKLDDVDV---QATTGDGQWTVGTS-PTQEKRMLP--SGMASSSQLIPE 147
+E R+ T EK L V+ + TT + + T + PT+ + P + +SS P
Sbjct: 461 TENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPT 520
Query: 148 ESGA---VGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQT---TED 201
E G + N P T N A+E P + +A + T E
Sbjct: 521 EHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEP 580
Query: 202 NEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQ 261
E +T P A K TSS E E P ++ + + E A +
Sbjct: 581 TENGQRT--PFANEKTTSSSAE------PTEHEERTPLANENTTPSPAEPTENRERTANE 632
Query: 262 SSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQRE---DEPSSQHADLPEQAAARSPSQT 318
++ P A P E++E+ ++ EP RE +E ++ P + R+P
Sbjct: 633 NTTPSPAG--PTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFAN 690
Query: 319 QKSTDSKDVCRMFDTQEPGKDADQTPAKTKNL----GEPEDYGRTSETQEKECETKDLPV 374
+K+T S + EP + ++TP +N EP +E +E+ K P
Sbjct: 691 EKTTSS--------SAEPTEHGERTPLANENTTLSPAEP------TENRERTANEKTTPF 736
Query: 375 QYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSK 434
++ + R+ + Q + PL E T S
Sbjct: 737 P---------AEPTENRERTANENTTPSPAQPTENGDRTPLANEKTTP----------SL 777
Query: 435 SKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAA----- 489
++ E G T + + + T+ S E EH E T A N+ ++PA
Sbjct: 778 AEPTENGKRTPFANEKT----------TSSSAEPTEHA-ERTPLANENTTSSPAEPTENR 826
Query: 490 ERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSET 549
ERT + P E + N + T +P E + E+ + E T
Sbjct: 827 ERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMT 886
Query: 550 PNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEA 609
P LA+E+ S ++ ++GE P T + TP
Sbjct: 887 P--LANEKTTLSP------------AEPTENGE-------RTPFTNEKTTPSSAE----- 920
Query: 610 VVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSL- 668
P GE L + P+R E G A P E E+T ++ S
Sbjct: 921 --PTEHGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVNEDTTPSSA 978
Query: 669 ----EIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESL 724
E T +E+ T + G+ + NE P+ E G T + N
Sbjct: 979 EPTENGERTPLANENTTTSPTESTEHGE-RTANEKTTPSPAEPTEHGERTPSAN------ 1031
Query: 725 DEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKE 768
E S E +E S E+ +P + +K+ E
Sbjct: 1032 -EKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEKTTLANE 1074
Score = 58.2 bits (139), Expect = 3e-08
Identities = 139/678 (20%), Positives = 230/678 (33%), Gaps = 108/678 (15%)
Query: 159 PWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKK- 217
P +KT + H P Q ++ Q + D T+K AG K
Sbjct: 99 PTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHI 158
Query: 218 TSSPTERKGQDKE------ISQEGDEPAR--EQSVSKI-RDQFGEQEGNLATQSSPPKEA 268
T +P + K ++++ D+ R E+S+S + + + + +S +
Sbjct: 159 TPAPKSKINCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQT 218
Query: 269 TQRPCEDQEVRTEKEKHS-NIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDV 327
Q+ E T K + P + E S+ ++ ++ Q++ + ++
Sbjct: 219 KQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANEL 278
Query: 328 CRMF--DTQEPGKDADQTPAKTKNLGEP-EDYGRTS------------ETQEKECETKDL 372
+ T+ G+ A++ T + EP E+ RT+ E +E+
Sbjct: 279 TQSLAEPTEHGGRTANEN--NTPSPAEPTENRERTANENTTLSPAEPIENRERTANENTA 336
Query: 373 PVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLE-TQTQDGKYQELQG 431
P G E + + P HG ++ + T P E T+ + E
Sbjct: 337 PFPAGPTENREMTANENTTLFPAEPTEHG---ERTANENTTPSPAEPTEHGERTANENTT 393
Query: 432 LSKSKDAEKGSETQYL----------SSEGGDQTHPELEGTAVSGEEAEHTKEGTA-EAF 480
S ++ E G T + S+E G++T E T S E +E TA E
Sbjct: 394 PSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENT 453
Query: 481 VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT 540
S P R A E+T L+P+E E T KT P E + Q +PF
Sbjct: 454 TPSPAGPTENRETTANEKTT-LSPVEPTENRETTANEKTTPSPAEPTENGQ----RTPF- 507
Query: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNN------NPDT 594
A+E+ SSS ++ +HGE + N P
Sbjct: 508 -------------ANEKTTSSS------------AEPTEHGERTPLANENTTPSPAEPTE 542
Query: 595 QRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPE 654
R+ T EK A P G+ L ++ P+ E G T P
Sbjct: 543 NRERTANEKTTPSPA-EPTENGDRTPLANEKTTPSLAEPTENGQRT------------PF 589
Query: 655 AQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRAT 714
A E T + E T +E+ T + + NE P+ E T
Sbjct: 590 ANEKTTSSSAEPTEHEERTPLANENTTPS-PAEPTENRERTANENTTPSPAGPTENREMT 648
Query: 715 EAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVP 774
+ T L + E +E +E+ SP E G Q++P E +S
Sbjct: 649 ANEKTTLFPAE---------PTENRERTANEKTTSSPAEPTENG--QRTPFANEKTTS-- 695
Query: 775 WSSLEKQMQRDQEPCSVE 792
SS E ++ P + E
Sbjct: 696 -SSAEPTEHGERTPLANE 712
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 62.0 bits (149), Expect = 2e-09
Identities = 127/669 (18%), Positives = 245/669 (36%), Gaps = 127/669 (18%)
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVS 245
D S E + + DN+G GS S ERK + + S ++ ++
Sbjct: 808 DFDSSEDEKHSKKGMDNQGHKNLKTSQEGS---SDDAERKQERETFSSAEGTVDKDTTIM 864
Query: 246 KIRDQFGE-QEGNLATQSSPPKEATQRPCEDQEVRT-----EKEKH-------------S 286
++RD+ + Q+ + +T ++ EVR EK KH S
Sbjct: 865 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS 924
Query: 287 NIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTD-SKDVCRMFDTQEPGKDADQTPA 345
+I E L+++ + D ++ + + + +K +D K V +M E D +
Sbjct: 925 DIAEKFLKKDQSDETSEDD--KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP 982
Query: 346 KTKNL------------GEPEDYGRTSETQEKECETKDLPVQYGSRNGS--ETSDMRDER 391
+ + + G + ++ + ++K + KD Y ++ ++ D +++
Sbjct: 983 EREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDK 1042
Query: 392 KERRGPEAH--------GTAGQKERDRKTRPLVLETQTQDG-----------KYQELQGL 432
K + G G + +K +D + + +DG + +E + L
Sbjct: 1043 KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL 1102
Query: 433 SK---SKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAA 489
S +K+ + GS + +E + + + + S ++A KE + S A
Sbjct: 1103 SSKRNTKEIQSGSSSS--DAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1160
Query: 490 ERTLGARERTQDLAPLEKQSVGENTR------------VTKTH--------------DQP 523
+ T + + D+ ++ S+GE + V +H P
Sbjct: 1161 DITSSS---SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217
Query: 524 VEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQ---GDQH 580
V +D DPE+ + N + E+G+S E E + Q++ GD+
Sbjct: 1218 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1277
Query: 581 GESVQGGHNNNPDTQRQGTPGEKNRALE---AVVPAVRGEDVQLTEDQEQPARGEHKNQG 637
++ Q ++ D++ P ++R L V GE+ + + + +G ++ +
Sbjct: 1278 AKN-QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKV 1336
Query: 638 PGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRN 697
+ + +G E + S + DE R L+E+ Q S Q R
Sbjct: 1337 SSEDSEDSDFQESGVSE-EVSESEDEQRPRTRSAKKAELEEN---QRSYKQKK----KRR 1388
Query: 698 ELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGE 757
+KVQ SS E K + E + E KE EEE+E +E E
Sbjct: 1389 RIKVQEDSSSENKSNSEEEE-------------------EEKEEEEEEEEEEEEEE-EDE 1428
Query: 758 GGDQKSPAK 766
D KSP K
Sbjct: 1429 NDDSKSPGK 1437
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/242 (21%), Positives = 87/242 (35%), Gaps = 29/242 (11%)
Query: 131 KRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQ 190
K L S SS PEE G R E PG+ N ++ E+S+
Sbjct: 1243 KANLSSDEDGSSDDEPEE----GKKRTGKQNEEN----PGDEEAKNQVNSESDSDSEESK 1294
Query: 191 E------------VAQDIQTTEDNEGQLKTNKPMAGS--KKTSSPTERKG--QDKEISQE 234
+ D ++ E+ + + K +K + G +K SS Q+ +S+E
Sbjct: 1295 KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEE 1354
Query: 235 GDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQ 294
E EQ + E E N + K + ED + +E +
Sbjct: 1355 VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEE 1414
Query: 295 REDEPSSQHADLPEQAAARSPSQTQKSTDS--KDVCRMFDTQEPGKDADQTPAKTKNLGE 352
E+E + + E ++SP + +K KD +TQ K+ ++ + K + E
Sbjct: 1415 EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE---RRKRIAE 1471
Query: 353 PE 354
E
Sbjct: 1472 RE 1473
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 62.0 bits (149), Expect = 2e-09
Identities = 127/669 (18%), Positives = 245/669 (36%), Gaps = 127/669 (18%)
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVS 245
D S E + + DN+G GS S ERK + + S ++ ++
Sbjct: 846 DFDSSEDEKHSKKGMDNQGHKNLKTSQEGS---SDDAERKQERETFSSAEGTVDKDTTIM 902
Query: 246 KIRDQFGE-QEGNLATQSSPPKEATQRPCEDQEVRT-----EKEKH-------------S 286
++RD+ + Q+ + +T ++ EVR EK KH S
Sbjct: 903 ELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS 962
Query: 287 NIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTD-SKDVCRMFDTQEPGKDADQTPA 345
+I E L+++ + D ++ + + + +K +D K V +M E D +
Sbjct: 963 DIAEKFLKKDQSDETSEDD--KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP 1020
Query: 346 KTKNL------------GEPEDYGRTSETQEKECETKDLPVQYGSRNGS--ETSDMRDER 391
+ + + G + ++ + ++K + KD Y ++ ++ D +++
Sbjct: 1021 EREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDK 1080
Query: 392 KERRGPEAH--------GTAGQKERDRKTRPLVLETQTQDG-----------KYQELQGL 432
K + G G + +K +D + + +DG + +E + L
Sbjct: 1081 KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL 1140
Query: 433 SK---SKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAA 489
S +K+ + GS + +E + + + + S ++A KE + S A
Sbjct: 1141 SSKRNTKEIQSGSSSS--DAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA 1198
Query: 490 ERTLGARERTQDLAPLEKQSVGENTR------------VTKTH--------------DQP 523
+ T + + D+ ++ S+GE + V +H P
Sbjct: 1199 DITSSS---SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1255
Query: 524 VEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQ---GDQH 580
V +D DPE+ + N + E+G+S E E + Q++ GD+
Sbjct: 1256 VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1315
Query: 581 GESVQGGHNNNPDTQRQGTPGEKNRALE---AVVPAVRGEDVQLTEDQEQPARGEHKNQG 637
++ Q ++ D++ P ++R L V GE+ + + + +G ++ +
Sbjct: 1316 AKN-QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKV 1374
Query: 638 PGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRN 697
+ + +G E + S + DE R L+E+ Q S Q R
Sbjct: 1375 SSEDSEDSDFQESGVSE-EVSESEDEQRPRTRSAKKAELEEN---QRSYKQKK----KRR 1426
Query: 698 ELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGE 757
+KVQ SS E K + E + E KE EEE+E +E E
Sbjct: 1427 RIKVQEDSSSENKSNSEEEE-------------------EEKEEEEEEEEEEEEEE-EDE 1466
Query: 758 GGDQKSPAK 766
D KSP K
Sbjct: 1467 NDDSKSPGK 1475
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/242 (21%), Positives = 87/242 (35%), Gaps = 29/242 (11%)
Query: 131 KRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQ 190
K L S SS PEE G R E PG+ N ++ E+S+
Sbjct: 1281 KANLSSDEDGSSDDEPEE----GKKRTGKQNEEN----PGDEEAKNQVNSESDSDSEESK 1332
Query: 191 E------------VAQDIQTTEDNEGQLKTNKPMAGS--KKTSSPTERKG--QDKEISQE 234
+ D ++ E+ + + K +K + G +K SS Q+ +S+E
Sbjct: 1333 KPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEE 1392
Query: 235 GDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQ 294
E EQ + E E N + K + ED + +E +
Sbjct: 1393 VSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEE 1452
Query: 295 REDEPSSQHADLPEQAAARSPSQTQKSTDS--KDVCRMFDTQEPGKDADQTPAKTKNLGE 352
E+E + + E ++SP + +K KD +TQ K+ ++ + K + E
Sbjct: 1453 EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEE---RRKRIAE 1509
Query: 353 PE 354
E
Sbjct: 1510 RE 1511
>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
critical region 1 [Homo sapiens]
Length = 1400
Score = 61.6 bits (148), Expect = 3e-09
Identities = 116/565 (20%), Positives = 187/565 (33%), Gaps = 52/565 (9%)
Query: 127 PTQEKRMLPSGMASSSQLIPEESGA-VGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEG 185
PT+ + M + + P E G N P T + A+E+ P
Sbjct: 404 PTENREMTANENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTE 463
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNK-PMAGSKKTSSPTERKGQDKEISQEGDEPAREQSV 244
+ A D T+ E + P+A T SP E + + E P+
Sbjct: 464 HGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPT 523
Query: 245 SKIRDQFGEQEGNLATQSSP--PKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS- 301
E N T SP P E + ++ + E N Q P E SS
Sbjct: 524 EN-----RETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSS 578
Query: 302 ----QHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQ----EPGKDADQTPAK----TKN 349
+H + A + + T++++ T EP ++ D+TP T +
Sbjct: 579 AEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPS 638
Query: 350 LGEPEDYG-RTSETQEKECETKDLPVQYGSR----NGSETSDMRDERKERRGPEAHGTAG 404
L EP + G RT EK + P ++ R N + T + + R T
Sbjct: 639 LAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTP 698
Query: 405 QKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAV 464
+ R + +T + + ++ + EK + + +E G +T E T
Sbjct: 699 SPAGPTENREMTANEKTTLFPAEPTENRERTAN-EKTTSSPAEPTENGQRTPFANEKTTS 757
Query: 465 SGEEAEHTKEGTAEAFVNSKNAPAA-----ERTLGARERTQDLAPLEKQSVGENTRVTKT 519
S E E T A N+ +PA ERT + P E + N T +
Sbjct: 758 SSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTTPS 817
Query: 520 HDQPVEEED--GYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQG 577
QP E D E + E TP A+E+ SSS ++
Sbjct: 818 PAQPTENGDRTPLANEKTTPSLAEPTENGKRTP--FANEKTTSSS------------AEP 863
Query: 578 DQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVV--PAVRGEDVQLTEDQE-QPARGEHK 634
+H E + N + + T + A E PA E+ + T +++ P E
Sbjct: 864 TEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEPT 923
Query: 635 NQGPGTKGPGAAVEPNGHPEAQEST 659
T + P E +E T
Sbjct: 924 ENREWTANENTTLSPAEPTEHEEMT 948
Score = 58.9 bits (141), Expect = 2e-08
Identities = 137/676 (20%), Positives = 228/676 (33%), Gaps = 104/676 (15%)
Query: 159 PWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKK- 217
P +KT + H P Q ++ Q + D T+K AG K
Sbjct: 161 PTGNSKTIDHKSSTDNHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHI 220
Query: 218 TSSPTERKGQDKE------ISQEGDEPAR--EQSVSKI-RDQFGEQEGNLATQSSPPKEA 268
T +P + K ++++ D+ R E+S+S + + + + +S +
Sbjct: 221 TPAPKSKINCRKSTTGKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQT 280
Query: 269 TQRPCEDQEVRTEKEKHS-NIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDV 327
Q+ E T K + P + E S+ ++ ++ Q++ + ++
Sbjct: 281 KQKSTSFPEKITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANEL 340
Query: 328 CRMF--DTQEPGKDADQ--TPA---------KTKNLGEPEDYGRTSETQEKECETKDLPV 374
+ T+ G+ A++ TP+ +T N +E +E+ P
Sbjct: 341 TQSLAEPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAEPTENRERTANENTAPF 400
Query: 375 QYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLE-TQTQDGKYQELQGLS 433
G E + + P HG ++ + T P E T+ + E S
Sbjct: 401 PAGPTENREMTANENTTLFPAEPTEHG---ERTANENTTPSPAEPTEHGERTANENTTPS 457
Query: 434 KSKDAEKGSETQYL----------SSEGGDQTHPELEGTAVSGEEAEHTKEGTA-EAFVN 482
++ E G T + S+E G++T E T S E +E TA E
Sbjct: 458 PAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTP 517
Query: 483 SKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQS 542
S P R A E+T L+P+E E T KT P E + Q +PF
Sbjct: 518 SPAGPTENRETTANEKTT-LSPVEPTENRETTANEKTTPSPAEPTENGQ----RTPF--- 569
Query: 543 DEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNN------NPDTQR 596
A+E+ SSS ++ +HGE + N P R
Sbjct: 570 -----------ANEKTTSSS------------AEPTEHGERTPLANENTTPSPAEPTENR 606
Query: 597 QGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQ 656
+ T EK A P G+ L ++ P+ E G T P A
Sbjct: 607 ERTANEKTTPSPA-EPTENGDRTPLANEKTTPSLAEPTENGQRT------------PFAN 653
Query: 657 ESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEA 716
E T + E T +E+ T + + NE P+ E T
Sbjct: 654 EKTTSSSAEPTEHEERTPLANENTTPS-PAEPTENRERTANENTTPSPAGPTENREMTAN 712
Query: 717 QNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWS 776
+ T L + E +E +E+ SP E G Q++P E +S S
Sbjct: 713 EKTTLFPAE---------PTENRERTANEKTTSSPAEPTENG--QRTPFANEKTTS---S 758
Query: 777 SLEKQMQRDQEPCSVE 792
S E ++ P + E
Sbjct: 759 SAEPTEHGERTPLANE 774
Score = 38.9 bits (89), Expect = 0.022
Identities = 84/392 (21%), Positives = 141/392 (35%), Gaps = 72/392 (18%)
Query: 127 PTQEKRMLP--SGMASSSQLIP---EESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNK 181
PT+ + P + +SS P EE + N P T N A+E+ P
Sbjct: 642 PTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANENTTPSPA 701
Query: 182 HLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTE--RKGQ-----DKEISQE 234
G +++E+ + +TT + + A K TSSP E GQ +++ +
Sbjct: 702 ---GPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSS 758
Query: 235 GDEPAREQSVSKIRDQ------FGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNI 288
EP + + ++ G E T + P E++E RT E +
Sbjct: 759 SAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTTPFPAEPTENRE-RTANENTTPS 817
Query: 289 QEPPLQRED------EPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQ 342
P + D E ++ P + R+P +K+T S + EP + A++
Sbjct: 818 PAQPTENGDRTPLANEKTTPSLAEPTENGKRTPFANEKTTSS--------SAEPTEHAER 869
Query: 343 TPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSE-TSDMRDERKERRGPEAHG 401
TP +N TS E P + R +E T+ E E R
Sbjct: 870 TPLANEN--------TTSSPAE--------PTENRERTANEKTTQFPAEPTENR------ 907
Query: 402 TAGQKERDRKTRPLVLE-TQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELE 460
+ + KT P E T+ ++ E LS ++ E T + E L+
Sbjct: 908 ---ESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLMVDE-------NLQ 957
Query: 461 GTAVSGEEAEHTKE--GTAEAFVNSKNAPAAE 490
G AE K+ T + S+++ A+E
Sbjct: 958 APFRQGSCAERPKDICATVASTTGSESSTASE 989
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 58.9 bits (141), Expect = 2e-08
Identities = 129/674 (19%), Positives = 244/674 (36%), Gaps = 88/674 (13%)
Query: 1 MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQ-PCVLHAVEKNSNL 59
MP+LL+ V+ VI+ F++YA++ TL ELK+L++ EF + P V+
Sbjct: 1 MPKLLQGVITVIDVFYQYATQHGEYDTLNKAELKELLENEFHQILKNPNDPDTVDIILQS 60
Query: 60 LNIDSNGIISFDEFVLAIFNLL----NLCYLDIKSLLSSELR------QVTKPEKEKLDD 109
L+ D N + F E++L IF L+ + D + S+LR Q + E EK ++
Sbjct: 61 LDRDHNKKVDFTEYLLMIFKLVQARNKIIGKDYCQVSGSKLRDDTHQHQEEQEETEKEEN 120
Query: 110 VDVQATTGDGQWTVGTSPTQEKRM---LPSGMASSSQLIPEESGAVGNNRVDPWREAKTH 166
+++ W+ G + + + + L G S S+ + + G + +
Sbjct: 121 KRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSFQRDFSGQH----------N 170
Query: 167 NFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTE-----DNEGQLKTNKPM-AGSKKTSS 220
++ G++S + + + + + Q + Q+ GQ +N +GS ++S
Sbjct: 171 SYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSG 230
Query: 221 PTERK---GQDKEISQEGDEPAREQSVSKIRDQFGEQ---EGNLATQSSPPKEATQRPCE 274
++ K GQ SQ G + + G+ E + ++ S
Sbjct: 231 FSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGS 290
Query: 275 DQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDS-KDVCRMFDT 333
Q + ++ + Q P R S + + + S S ++ +S F
Sbjct: 291 RQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQ 350
Query: 334 QEPGKDADQTPAK-TKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERK 392
E G +K G G+ T + + Q+GS + +S + E
Sbjct: 351 HESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSG----QHGSSSRQSSSYGQHESA 406
Query: 393 ER----RGPEAHGTA-----GQKERDRKTRPLVLETQTQDGK------------YQELQG 431
R RG + G+ GQ+ P + T G+ Y G
Sbjct: 407 SRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFG 466
Query: 432 LSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNS--KNAPAA 489
+S TQ+ S G H + G+ SG+ + ++G++ +S ++ +
Sbjct: 467 HHESSSEHSSGYTQHGSGSGHSSGHGQ-HGSR-SGQSSRGERQGSSAGSSSSYGQHGSGS 524
Query: 490 ERTLGARERTQDLAPLEKQSVGENTRVTKTHDQ---------------PVEEEDGYQG-- 532
++LG S G + ++ P E G+
Sbjct: 525 RQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGL 584
Query: 533 EDPESPFTQS----DEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGH 588
ES QS GSS +S + G++S ++ G + Q HG+ G
Sbjct: 585 GHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSS 644
Query: 589 NNNPDTQRQGTPGE 602
++ Q+ G+
Sbjct: 645 QSSRYGQQGSGSGQ 658
Score = 37.7 bits (86), Expect = 0.049
Identities = 57/292 (19%), Positives = 104/292 (35%), Gaps = 23/292 (7%)
Query: 375 QYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQE---LQG 431
Q+GSR+G + R ER+G A ++ + +R + ++ G Q +G
Sbjct: 493 QHGSRSGQSS------RGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRG 546
Query: 432 LSKSKDAEKGSETQYLSSEGGDQTHPELEGTA--VSGEEAEHTKEGTAEAFVNSKNAPAA 489
+S + S + G + E + SG + ++ G + + ++
Sbjct: 547 RHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGH 606
Query: 490 ERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVE---------EEDGYQGEDPESPFT 540
T G T + Q G + + +H Q ++ G+ P
Sbjct: 607 SSTHGQHGSTSGQSSSCGQH-GATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRH 665
Query: 541 QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP 600
SD G S + S G SSS V G S G + G G++ + +
Sbjct: 666 GSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSG 725
Query: 601 GEKN--RALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPN 650
K+ R+ ++ G L+ Q G H++ G G +G G+ P+
Sbjct: 726 YRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPS 777
Score = 33.1 bits (74), Expect = 1.2
Identities = 58/307 (18%), Positives = 98/307 (31%), Gaps = 38/307 (12%)
Query: 375 QYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLS- 433
Q+GSR+G + R R ++G G R Q + S
Sbjct: 259 QHGSRSGQSSRGER-HRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSG 317
Query: 434 -KSKDAEKGSETQYLSSEG-----GDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAP 487
S + GS + Y S G QT + + SG+ + ++K G+ +S+
Sbjct: 318 HSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQH 377
Query: 488 AAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSS 547
+ + + + S G++ ++ H + G+ P Q GS
Sbjct: 378 GSTSGQASSSGQHGSSSRQSSSYGQHESASR-HSSGRGQHSSGSGQSPGHG--QRGSGSG 434
Query: 548 ETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESV----------------QGGHNNN 591
++P+S G S + V G S G H ES GH +
Sbjct: 435 QSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQH 494
Query: 592 PDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNG 651
Q + GE+ +G + Q G ++ G G G+ P+
Sbjct: 495 GSRSGQSSRGER-----------QGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSP 543
Query: 652 HPEAQES 658
ES
Sbjct: 544 SRGRHES 550
Score = 30.4 bits (67), Expect = 7.8
Identities = 27/124 (21%), Positives = 48/124 (38%), Gaps = 10/124 (8%)
Query: 545 GSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKN 604
GSS +S + G++S ++ G S Q HG+ G +Q G + +
Sbjct: 2007 GSSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSG------SSQSSGYGRQGS 2060
Query: 605 RALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPN-GHPEAQESTAGDE 663
+ ++ RG + + + G ++ G GPG GH ES++G
Sbjct: 2061 GSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGH---HESSSGQS 2117
Query: 664 NRKS 667
+ S
Sbjct: 2118 SSYS 2121
>gi|62244004 modulator of estrogen induced transcription isoform b
[Homo sapiens]
Length = 1016
Score = 58.9 bits (141), Expect = 2e-08
Identities = 116/547 (21%), Positives = 217/547 (39%), Gaps = 103/547 (18%)
Query: 82 NLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASS 141
NL +K++L S L+Q + E D++++ +T T PT+ K
Sbjct: 38 NLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTD----TPNKKPTKGKG--------- 84
Query: 142 SQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTED 201
++ + G+AS +D K E + Q +D
Sbjct: 85 -------------------KKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKD 125
Query: 202 NEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSV--SKIRDQFGEQEGNLA 259
+E + + SK+ S E K + I EG E ++ + +I Q GE + L
Sbjct: 126 SEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLT 185
Query: 260 TQSSPPKEATQRPC---EDQEVRTEKEKHSNIQEP-------PLQREDEPSSQH--ADLP 307
Q +E + D E E H+ ++E +Q ED + DL
Sbjct: 186 AQDGEEEENEKEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLL 245
Query: 308 EQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDA-DQTPAKTKNLGEPEDYGRTSETQE-- 364
E + K TDS+ + G+DA Q+P K E +DY + ++
Sbjct: 246 E------TGKNVKITDSE-----ASKPKDGQDAIAQSPEK-----ESKDYEMNANHKDGK 289
Query: 365 KECETKDLPVQYGSRNGSETSDMRDERKE--RRGPEAHGTAGQKERDRKTRPLVLETQTQ 422
KE K PV+ +R S+ ++ D+ K+ ++GP + G +GQ + K +++
Sbjct: 290 KEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSK--------ESK 341
Query: 423 DGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAE-------HTKEG 475
D K + SKD +KGS + S G + + G + + + A+ + K
Sbjct: 342 DSK-------TSSKD-DKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVL 393
Query: 476 TAEAFVNSKNAPAAE-----RTLGARERTQDLAPLEKQSV-GENTRVTKTHDQPVEEEDG 529
+A+ N++ +P A+ + E ++ +A L + + G+ V K P ++E
Sbjct: 394 SAKVVTNAR-SPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMK 452
Query: 530 YQGEDPESPFTQSD-----EGSSETPNSLASEEGNSSSETGELPVQGDSQSQG-DQHGES 583
+ ++ S + D + SS+T S+ EE SS ++ + + + +G D+ ++
Sbjct: 453 KENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDN 512
Query: 584 VQGGHNN 590
G +
Sbjct: 513 GASGQTS 519
Score = 36.6 bits (83), Expect = 0.11
Identities = 105/535 (19%), Positives = 189/535 (35%), Gaps = 89/535 (16%)
Query: 177 DPKNKHL--EGDEQSQEVAQ-DIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEIS- 232
DP K + E DE+S + D + T D KT + +K SS K + K+
Sbjct: 445 DPSKKEMKKENDEKSSSRSSGDKKNTSDRSS--KTQASVKKEEKRSSEKSEKKESKDTKK 502
Query: 233 -----QEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSN 287
++ D A Q+ I+ E++ ++++S + D + + ++
Sbjct: 503 IEGKDEKNDNGASGQTSESIKKS--EEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEK 560
Query: 288 IQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDT----------QEPG 337
I ++E + D + P + K ++ F+ +E
Sbjct: 561 IHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIA 620
Query: 338 KDADQTPAKTKNLGEPEDYGRTSETQEK-ECETKDLPVQYGSRNGSETSDMRDERKERRG 396
+ + + + + E E+ R +E+ E E + L + R E +R E++ R+
Sbjct: 621 ERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRK- 679
Query: 397 PEAHGTAGQKE---------------RDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKG 441
EA A ++E R+ RP ++ + D + E + LS DA G
Sbjct: 680 -EAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFG 738
Query: 442 SETQYLSSEG--GDQTHPEL----EGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGA 495
+ Y + D H E E +AV E ++ K P A R +
Sbjct: 739 HGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQS-EGKKARPTARREDPS 797
Query: 496 RER----------------TQDLAPLEKQSV---GENTRVTKTHDQPVEEEDGYQGEDPE 536
ER +L +++ V + R HD+P D
Sbjct: 798 FERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRP----------DIT 847
Query: 537 SPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQR 596
P + G + + + EG+ S++ E V+ +S + G SV+G P R
Sbjct: 848 HPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGA----PPGNR 903
Query: 597 QGTPGEKNRALEAVVPAVRG-------EDVQLTEDQEQPARGEHKN-QGPGTKGP 643
G +R + V RG E+ + E + G K GP ++GP
Sbjct: 904 SSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGP 958
Score = 31.6 bits (70), Expect = 3.5
Identities = 34/155 (21%), Positives = 68/155 (43%), Gaps = 11/155 (7%)
Query: 617 EDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGAL 676
++++LT + P N+ P TKG G E + S D K E+E A
Sbjct: 64 DNIELTVSTDTP------NKKP-TKGKGKKHEAD-ELSGDASVEDDAFIKDCELENQEAH 115
Query: 677 DEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQL 736
++D D+L + G+ + N + S++E K + +E +++++ S +I+
Sbjct: 116 EQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEA 175
Query: 737 ETKEP---VTSEEEDESPQELAGEGGDQKSPAKKE 768
+ E +T+++ +E E G + A +E
Sbjct: 176 QEGEDDTFLTAQDGEEEENEKEGSLAEADHTAHEE 210
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 58.5 bits (140), Expect = 3e-08
Identities = 97/521 (18%), Positives = 199/521 (38%), Gaps = 60/521 (11%)
Query: 102 PEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWR 161
P KEK D+ ++ + P++EK P+ M+S RV +
Sbjct: 226 PSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSS---------------RVKSYN 270
Query: 162 EAKTHNFPGEASEHNDPKNKHLEGDEQSQE-VAQDIQTTEDNEGQLKTNKPMA------- 213
+A T + P S+ P+ +++ V + + +T K +
Sbjct: 271 QASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS 330
Query: 214 -------GSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPK 266
G + S T R+G+ S+ P++E+S S R E++ SSP K
Sbjct: 331 QSRSHSKGKSQNQSRTPRRGRSHNWSRN---PSKERSHSHSRSSSKERDHR--GSSSPRK 385
Query: 267 EATQRPCEDQEVRTEKEK-HSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSK 325
E+ + Q K++ HS + P R+ S +++ +RSP++ + + S+
Sbjct: 386 ESGR----SQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSR 441
Query: 326 DVCRMFD---TQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYG----S 378
+ D ++ P K D + +++ N R S ++E++ P + S
Sbjct: 442 SPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR-SPSKERDHSQLGSPSKERDHRRS 500
Query: 379 RNGSETSDMRDER---KERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKS 435
R+ S+ R R KER + + +++R + P ++Q E + +S
Sbjct: 501 RSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQS 560
Query: 436 KDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVN-SKNAPAAERTLG 494
+ K + + S ++ E + S EE +H++ + S+ +++
Sbjct: 561 RSPSKERDRRRWRSPSKER---ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAH 617
Query: 495 ARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLA 554
+R RT K+ +R + P + + SP S + TP+ +
Sbjct: 618 SRSRTPS-----KEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672
Query: 555 SEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQ 595
S ++ G+ Q DSQ+ ++ G +++ ++
Sbjct: 673 SHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 57.8 bits (138), Expect = 5e-08
Identities = 115/609 (18%), Positives = 227/609 (37%), Gaps = 99/609 (16%)
Query: 201 DNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKI-----RDQFGEQE 255
D G K K A +K+ S E++ ++++ S+ G P + S + + E +
Sbjct: 633 DKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGK 692
Query: 256 GNLATQSSPPKEATQRPCEDQEV--RTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAAR 313
+ + S ++A ++ ++E+ + E EK+ N+ + L E+ S H
Sbjct: 693 SDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQM 752
Query: 314 SPSQTQKST--DSKDVCRMF-----DTQEPGKDADQTP------AKTKNLG----EPEDY 356
P +T K +++ + ++F T+E K+A+++P +KTK+L + +
Sbjct: 753 QPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSF 812
Query: 357 GRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLV 416
G+ E E L + N + +S DE Q +++K + +
Sbjct: 813 GQNEAGSEPHIEAHSLELS-SLDNKNFSSATEDE------------IDQCVKEKKLKRKI 859
Query: 417 LETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEG----GDQTHPELEGTAVSGEEAEHT 472
L + + K + G+ + + + + SEG + H E E + AE
Sbjct: 860 LGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESN 919
Query: 473 ---KEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHD-QPVEEED 528
++ T+E F ++PA E + +D PL +G T V D ++E+D
Sbjct: 920 QCIQQLTSERF----DSPAEETVNIPLKEDEDAMPL----IGPETLVCHEVDLDDLDEKD 971
Query: 529 GYQGED---------------PESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDS 573
ED P P S +P +L+ +E S ++ ++ DS
Sbjct: 972 KTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDS 1031
Query: 574 QSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEH 633
++ Q G +R+ G + + E + Q++P+ G
Sbjct: 1032 IAEESQEGL-----------CERESANGFETNVASGTCSIIVQERESREKGQKRPSDGNS 1080
Query: 634 ----KNQGPGTKGPGAAVEPNGHPEAQESTAGD----ENRKSLEIEITGALDEDFTDQLS 685
K Q K AA + + Q S + D +N L+ + + T+++S
Sbjct: 1081 GLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSNELD-------NMNSTERIS 1133
Query: 686 LMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSE 745
+Q + E++ S K E + L + E + A + + + S
Sbjct: 1134 FLQ-----EKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMSSASSDTGMSP 1188
Query: 746 EEDESPQEL 754
PQ +
Sbjct: 1189 SSSSPPQNV 1197
Score = 56.2 bits (134), Expect = 1e-07
Identities = 87/444 (19%), Positives = 170/444 (38%), Gaps = 77/444 (17%)
Query: 101 KPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPW 160
K EK+ L++ +A D + + ++ + + S S + I +S G R+
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR-GRRRI--- 473
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
A+ N + E ++K + D ++++V D +T E E +L + +K
Sbjct: 474 --ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 221 PTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPC---EDQE 277
+++ DK+ +E ++ + D GE++ E PC +
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEED-----------EEDMEPCLTGTKVK 580
Query: 278 VRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPG 337
V+ + K I E + KST+ D ++ G
Sbjct: 581 VKYGRGKTQKIYEASI--------------------------KSTEIDDGEVLYLVHYYG 614
Query: 338 KDADQTP-AKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRG 396
+ K + P D G + Q+K+ + K+ SE + RDE
Sbjct: 615 WNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKE---------DSEKDEKRDE------ 659
Query: 397 PEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTH 456
++++ ++ RP + T + + Y GLSK+ ++E S++ SE D
Sbjct: 660 --------ERQKSKRGRPPLKSTLSSNMPY----GLSKTANSEGKSDSCSSDSETEDALE 707
Query: 457 PELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLE--KQSVGENT 514
L +S ++ E + ++ +N + L +RTQ + PLE K VGEN
Sbjct: 708 KNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQPLETLKLEVGENE 766
Query: 515 RVTKTHDQPVEEEDGYQGEDPESP 538
++ + +E+ + + E +SP
Sbjct: 767 QIVQIFGNKMEKTEEVKKEAEKSP 790
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 57.4 bits (137), Expect = 6e-08
Identities = 78/423 (18%), Positives = 164/423 (38%), Gaps = 33/423 (7%)
Query: 187 EQSQEVAQDIQTTEDNEGQLKTN-KPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVS 245
EQ +++ + + + E +L+ K + KK E+ + +E E +E REQ
Sbjct: 273 EQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332
Query: 246 KIR--DQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQH 303
R ++ EQE + Q ++ +R E E EKE+ QE ++E++ +
Sbjct: 333 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEE 392
Query: 304 ADLPEQAAARSPSQTQKSTD---SKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS 360
+ R +T + + K M++ +E + P + + L E E
Sbjct: 393 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452
Query: 361 E-TQEKECETKDLPVQYGSRNG-------SETSDMRDERKERRGPEAHGTAGQKER---- 408
E E+E + +D +G E D E++E+ + Q+ER
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512
Query: 409 DRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEE 468
D + R + Q +Q+ + + + K +TQ + DQ E + E
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEK------KTQEQEKKTWDQEEKMREEERMRERE 566
Query: 469 AEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEED 528
+ +E E + + E+ RE+ + + E++ + ++ + ++ E+E+
Sbjct: 567 KKMREE---EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 529 GYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGEL-----PVQGDSQSQGDQHGES 583
+ ++ E + +E E + +E + ++ +QG + +Q E
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE-EK 682
Query: 584 VQG 586
+QG
Sbjct: 683 MQG 685
Score = 43.5 bits (101), Expect = 9e-04
Identities = 81/495 (16%), Positives = 183/495 (36%), Gaps = 31/495 (6%)
Query: 186 DEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVS 245
+E+ +E + I+ E+ + + K + + Q+K + ++ E ++
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 246 KIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHAD 305
+ + + EQE + Q E ++ E +E +E+ QE ++ +++ + D
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ---KMRD 356
Query: 306 LPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS----- 360
E+ + +K ++ +M++ +E ++ ++ + K + E E+ R
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQ 416
Query: 361 -------ETQEKECETKDLPVQ------YGSRNGSETSDMRDERKERRGPEAHGTAGQKE 407
E +EKE + + LP Q E E K R E G +
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 476
Query: 408 RDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYL-SSEGGDQTHPELEGTAVSG 466
R K R + Q+ K ++ + ++ + + L E + ++
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKM 536
Query: 467 EEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEE 526
E + T+E + + + ER RER + + E++ + E + ++ + E
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEER---MREREKKMRE-EEEMMREQEEKMQEQEEKMRE 592
Query: 527 EDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQ----HGE 582
++ E E Q ++ + EE + E E+ + + + Q + E
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 583 SVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKG 642
Q + G++ + E ++G++ ++ E +E+ E K G K
Sbjct: 653 EKMREQEEKMREQEEKMQGQEEKMREQ-EEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Query: 643 PGAAVEPNGHPEAQE 657
G + G E +E
Sbjct: 712 WGQEEKMWGQEEMRE 726
Score = 42.4 bits (98), Expect = 0.002
Identities = 94/559 (16%), Positives = 206/559 (36%), Gaps = 63/559 (11%)
Query: 187 EQSQEVAQDIQTTEDNEGQLKTN-----------KPMAGSKKTSSPTERKGQDKEISQEG 235
+++ E+ + ++ E + +++ N K + +T++ E + +E +E
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQ 246
Query: 236 DEPAREQSVSKIR--DQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPL 293
++ R+Q R ++ EQEG + Q + +R E ++ E+EK Q+
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLR 306
Query: 294 QREDEPSSQHADLPEQ--------------------AAARSPSQTQKSTDSKDVCRMFDT 333
++E++ Q + EQ + Q QK D ++ RM++
Sbjct: 307 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE--RMWEQ 364
Query: 334 QEPGKDADQTPAKTKNLGEPE----DYGRTSETQEKECETKDLPVQYGSRNGSETSDM-- 387
E ++ ++ + + + E E + R E ++K E ++ + + + +M
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 388 --RDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSK-----SKDAEK 440
E +++R PE ++E+ ++ + E + + +E+ G K K E+
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 441 GSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQ 500
+ + DQ + E+ E +E E K E + ++TQ
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE-KEERMREQKKMWQQEEKMREEKKTQ 543
Query: 501 DLAPL---EKQSVGENTRVTKTHDQPVEEEDGYQG-----EDPESPFTQSDEGSSETPNS 552
+ +++ + E R+ + + EEE+ + ++ E + +E E
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Query: 553 LASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVP 612
+ +E + ++ Q + +Q + ++ EK R E
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE---E 660
Query: 613 AVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPE---AQESTAGDENRKSLE 669
+R ++ ++ +E+ E K QG K + G E QE + K
Sbjct: 661 KMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG 720
Query: 670 IEITGALDEDFTDQLSLMQ 688
E +E DQ MQ
Sbjct: 721 QEEMREKEERIRDQKEKMQ 739
Score = 38.5 bits (88), Expect = 0.029
Identities = 45/254 (17%), Positives = 102/254 (40%), Gaps = 24/254 (9%)
Query: 160 WREAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTS 219
WR+ K + E + D++ + Q+ + E +E + + M KK
Sbjct: 476 WRQEKMREQEDQMWEQEEKMR-----DQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 220 SPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVR 279
E+ ++K+ ++ + ++ + ++ E+E + + +E ++ E +E
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 280 TEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKD 339
E+E+ QE +Q ++E + + + Q Q+ M++ +E ++
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE-------MMWEQEEKMQE 643
Query: 340 ADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSE-----TSDMRDERKER 394
++ + E E+ R E + +E E K + R E MR++ ++
Sbjct: 644 QEE------KMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697
Query: 395 RGPEAHGTAGQKER 408
RG E GQ+E+
Sbjct: 698 RGQE-EKMWGQEEK 710
Score = 32.3 bits (72), Expect = 2.0
Identities = 83/458 (18%), Positives = 164/458 (35%), Gaps = 60/458 (13%)
Query: 391 RKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSE 450
R+E R E G ++E + + L Q ++ + QE + + K E+ + Q
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQ----- 313
Query: 451 GGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSV 510
E E+ E +E + + + E+ + RE+ Q + E++
Sbjct: 314 ---------EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM--REQEQKMRDQEERMW 362
Query: 511 GENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQ 570
++ R+ + ++ E+E ++ E+ Q +E E + EE + ++ Q
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEK----MQEEERIREREKKMREEEETMREQEEKMQKQ 418
Query: 571 GDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTE----DQE 626
++ + ++ + Q+Q P +K + E + E + E DQE
Sbjct: 419 EENMWEQEEK------------EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE 466
Query: 627 QPARGEHK--NQGPGTKGPGAAVEPNGHPEAQESTAGDENRKSLEI-EITGALDEDFTDQ 683
+ E K Q + E QE D+ + E E +E +Q
Sbjct: 467 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526
Query: 684 LSLMQLPGKGDSRNELKVQGPSSK----EEKGRATEA----------QNTLLESLDEDNS 729
+ Q K R E K Q K EEK R E + ++ +E
Sbjct: 527 KKMWQQEEK--MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584
Query: 730 ASLKIQLETKEPVTSEEE-----DESPQELAGEGGDQKSPAKKEHNSSVPWSSLEKQMQR 784
+ E +E + +EE +E E + +Q+ K + + W EK ++
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 785 DQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQK 822
+++ E + +EK+ Q +E+ +K
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK 682
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.4 bits (137), Expect = 6e-08
Identities = 132/674 (19%), Positives = 251/674 (37%), Gaps = 107/674 (15%)
Query: 126 SPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEG 185
S QEK+ LP +LIPEE + + P E K P + P+ K
Sbjct: 1206 SALQEKKPLPE----EKKLIPEEE-KIRSEEKKPLLEEKK---PTPEDKKLLPEAKTSAP 1257
Query: 186 DEQSQEVAQD-IQTTEDN-EGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQS 243
+EQ ++ + +Q E+ EG++ + T ++G+ + EG QS
Sbjct: 1258 EEQKHDLLKSQVQIAEEKLEGRV------------APKTVQEGKQPQTKMEGLPSGTPQS 1305
Query: 244 VSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH----SNIQEPPLQREDEP 299
+ K D+ + + Q PP A E + +TEKE S+ Q+P +
Sbjct: 1306 LPKEDDKTTK---TIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSD 1362
Query: 300 SSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRT 359
+ +D + PS TD KD+ + +++ + P D +
Sbjct: 1363 TGYSSDGISSSLGEIPSLIP--TDEKDILKGLKKDSFSQESSPS--------SPSDLAKL 1412
Query: 360 SETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPL--VL 417
T E ++ S + DE+ E++ + Q + KT+ L L
Sbjct: 1413 ESTVLSILE-------------AQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459
Query: 418 ETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTA 477
E + + +E Q + KD K Q + S + E + E + E ++
Sbjct: 1460 EITISEEEIKESQ--EERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESS 1517
Query: 478 EAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPES 537
E S+N+P +R + RT SVG ++ D+ +E+ GE+ +
Sbjct: 1518 E----SENSPVPQR----KRRT---------SVGSSSS-----DEYKQEDSQGSGEEEDF 1555
Query: 538 PFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQ 597
Q E S++ S + ++ ++ E+ +SQ + + G+ + T++
Sbjct: 1556 IRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKS 1615
Query: 598 GTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQE 657
T +++ + ED + ++ + E K+Q E
Sbjct: 1616 STSIDEDAGRRH---SWHDEDDEAFDESPELKYRETKSQ---------------ESEELV 1657
Query: 658 STAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQG-PSSKEEKGRATEA 716
T G R+ IE+ + + ++ + S + D EL+++ S E++ R +
Sbjct: 1658 VTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGS 1717
Query: 717 QNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPW- 775
+ S S + L+ E+ D SP GE Q+ + H +P
Sbjct: 1718 SSLHASSFTPGTSPTSVSSLD-------EDSDSSPSHKKGESKQQRKARHRPHGPLLPTI 1770
Query: 776 --SSLEKQMQRDQE 787
SS E++++ ++E
Sbjct: 1771 EDSSEEEELREEEE 1784
Score = 46.6 bits (109), Expect = 1e-04
Identities = 144/676 (21%), Positives = 241/676 (35%), Gaps = 106/676 (15%)
Query: 211 PMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQ 270
PM + S P +G K Q PA+ V K E + A + P +A Q
Sbjct: 963 PMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK------ETKAPAAEKLEP--KAEQ 1014
Query: 271 RPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRM 330
P RTE EK + PP++ +++ P++A P++ +KS + C +
Sbjct: 1015 APTVK---RTETEK----KPPPIKDSKSLTAE----PQKAVL--PTKLEKSPKPESTCPL 1061
Query: 331 FDTQ------EPGKDADQTPAKTK--NLGEPEDYGRTSETQEKECETKDLPVQYGSRNGS 382
T+ +P T K + NL +E QE C L Q
Sbjct: 1062 CKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLC----LNCQTQRAISG 1117
Query: 383 ETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGS 442
+ D+R GP+A E + + + + + QE++ ++ EK
Sbjct: 1118 QLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVK 1177
Query: 443 ETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDL 502
ET LS E P + T EE++ K+ A A K P
Sbjct: 1178 ET--LSME----KIPPMVTTDQKQEESKLEKD-KASALQEKKPLPE-------------- 1216
Query: 503 APLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSS 562
EK+ + E ++ +P+ EE ED + E + P + S
Sbjct: 1217 ---EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK----LLPEAKTSAPEEQKHDLLKSQV 1269
Query: 563 ETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAV----VPAVRGED 618
+ E ++G + Q G+ Q P Q P E ++ + + P +
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP 1329
Query: 619 VQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENR--------KSLEI 670
Q+ +E+ + + K+ ++ P + P G + S+ G + + E
Sbjct: 1330 DQVEPGKEKTEKEDDKSDTSSSQQPKS---PQGLSDTGYSSDGISSSLGEIPSLIPTDEK 1386
Query: 671 EITGALDEDFTDQLSLMQLPG-----KGDSRNELKVQGPSSKEEKG-RATEAQNTLLES- 723
+I L +D Q S P + + L+ Q + +EK + T+ E
Sbjct: 1387 DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP 1446
Query: 724 LDEDNSASLKIQLETKEPVTSEEEDESPQE----LAGEGGDQKSPAKKEHNSS------- 772
D++ + SL ET E SEEE + QE + Q P+ K+H
Sbjct: 1447 KDQEKTQSLS---ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDI 1503
Query: 773 ----VPWSSLEKQMQRDQEPC--SVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQI 826
P+ S+E+ + + P R +V SS +Y QE +EE + QI
Sbjct: 1504 TTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQE---DSQGSGEEEDFIRKQI 1560
Query: 827 AQASGPELCSVSLTSE 842
+ S E S S E
Sbjct: 1561 IEMSADEDASGSEDDE 1576
Score = 43.9 bits (102), Expect = 7e-04
Identities = 109/546 (19%), Positives = 203/546 (37%), Gaps = 53/546 (9%)
Query: 128 TQEKRMLPSGMASSSQLIPEES---GAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLE 184
++E+R + + S +Q +P+ S A + + +E + + P ++ DP
Sbjct: 49 SEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQP 108
Query: 185 GDEQSQEVAQDIQTTEDNEGQLKTNKPMAGS-KKTSSPTERKGQDKEISQEG--DEPARE 241
G +S+ T +E +L P S K++ S T+ K + K G E
Sbjct: 109 GLSKSRTT-----DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNAL 163
Query: 242 QSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS 301
+VS + ++F + L + S +E T + + + V+ E+ K I +PPLQ++
Sbjct: 164 SAVSSVVNKFNPFD--LISDSEASQEETTK--KQKVVQKEQGKPEGIIKPPLQQQPPKPI 219
Query: 302 QHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSE 361
+Q R P Q + S +Q+P K Q P K + P
Sbjct: 220 PK----QQGPGRDPLQQDGTPKS------ISSQQPEKIKSQPPGTGKPIQGP-------- 261
Query: 362 TQEKECETKDLPVQY-GSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
TQ + + LP+Q SR ++ +D+ RG + + +P +
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIV------RGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
Q +++ Q A+ T+ L+ + G P ++ + A+ A
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT-VKPPVQPPGTTKPPAQPLGPAKPPAQ 374
Query: 481 VNSKNAPAAERTLGARERTQD----LAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPE 536
P++E+ G + Q P ++ + +P+ ++ G Q
Sbjct: 375 QTGSEKPSSEQP-GPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 537 SPFTQS---DEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPD 593
T++ G + P A S+ +TG P + SQ G Q G P
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTG--PTKPPSQLPGPAKPPPQQPGPAK-PP 490
Query: 594 TQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHP 653
Q+ G+ ++ + P + + +QP + +Q PG+ P A P
Sbjct: 491 PQQPGSAKPPSQQPGSTKPPPQ-QPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKP 549
Query: 654 EAQEST 659
AQ+ST
Sbjct: 550 SAQQST 555
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.4 bits (137), Expect = 6e-08
Identities = 132/674 (19%), Positives = 251/674 (37%), Gaps = 107/674 (15%)
Query: 126 SPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLEG 185
S QEK+ LP +LIPEE + + P E K P + P+ K
Sbjct: 1206 SALQEKKPLPE----EKKLIPEEE-KIRSEEKKPLLEEKK---PTPEDKKLLPEAKTSAP 1257
Query: 186 DEQSQEVAQD-IQTTEDN-EGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQS 243
+EQ ++ + +Q E+ EG++ + T ++G+ + EG QS
Sbjct: 1258 EEQKHDLLKSQVQIAEEKLEGRV------------APKTVQEGKQPQTKMEGLPSGTPQS 1305
Query: 244 VSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH----SNIQEPPLQREDEP 299
+ K D+ + + Q PP A E + +TEKE S+ Q+P +
Sbjct: 1306 LPKEDDKTTK---TIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSD 1362
Query: 300 SSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRT 359
+ +D + PS TD KD+ + +++ + P D +
Sbjct: 1363 TGYSSDGISSSLGEIPSLIP--TDEKDILKGLKKDSFSQESSPS--------SPSDLAKL 1412
Query: 360 SETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPL--VL 417
T E ++ S + DE+ E++ + Q + KT+ L L
Sbjct: 1413 ESTVLSILE-------------AQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459
Query: 418 ETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTA 477
E + + +E Q + KD K Q + S + E + E + E ++
Sbjct: 1460 EITISEEEIKESQ--EERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESS 1517
Query: 478 EAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPES 537
E S+N+P +R + RT SVG ++ D+ +E+ GE+ +
Sbjct: 1518 E----SENSPVPQR----KRRT---------SVGSSSS-----DEYKQEDSQGSGEEEDF 1555
Query: 538 PFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQ 597
Q E S++ S + ++ ++ E+ +SQ + + G+ + T++
Sbjct: 1556 IRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKS 1615
Query: 598 GTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQE 657
T +++ + ED + ++ + E K+Q E
Sbjct: 1616 STSIDEDAGRRH---SWHDEDDEAFDESPELKYRETKSQ---------------ESEELV 1657
Query: 658 STAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQG-PSSKEEKGRATEA 716
T G R+ IE+ + + ++ + S + D EL+++ S E++ R +
Sbjct: 1658 VTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGS 1717
Query: 717 QNTLLESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPW- 775
+ S S + L+ E+ D SP GE Q+ + H +P
Sbjct: 1718 SSLHASSFTPGTSPTSVSSLD-------EDSDSSPSHKKGESKQQRKARHRPHGPLLPTI 1770
Query: 776 --SSLEKQMQRDQE 787
SS E++++ ++E
Sbjct: 1771 EDSSEEEELREEEE 1784
Score = 46.6 bits (109), Expect = 1e-04
Identities = 144/676 (21%), Positives = 241/676 (35%), Gaps = 106/676 (15%)
Query: 211 PMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQ 270
PM + S P +G K Q PA+ V K E + A + P +A Q
Sbjct: 963 PMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK------ETKAPAAEKLEP--KAEQ 1014
Query: 271 RPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRM 330
P RTE EK + PP++ +++ P++A P++ +KS + C +
Sbjct: 1015 APTVK---RTETEK----KPPPIKDSKSLTAE----PQKAVL--PTKLEKSPKPESTCPL 1061
Query: 331 FDTQ------EPGKDADQTPAKTK--NLGEPEDYGRTSETQEKECETKDLPVQYGSRNGS 382
T+ +P T K + NL +E QE C L Q
Sbjct: 1062 CKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLC----LNCQTQRAISG 1117
Query: 383 ETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGS 442
+ D+R GP+A E + + + + + QE++ ++ EK
Sbjct: 1118 QLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVK 1177
Query: 443 ETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDL 502
ET LS E P + T EE++ K+ A A K P
Sbjct: 1178 ET--LSME----KIPPMVTTDQKQEESKLEKD-KASALQEKKPLPE-------------- 1216
Query: 503 APLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSS 562
EK+ + E ++ +P+ EE ED + E + P + S
Sbjct: 1217 ---EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKK----LLPEAKTSAPEEQKHDLLKSQV 1269
Query: 563 ETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAV----VPAVRGED 618
+ E ++G + Q G+ Q P Q P E ++ + + P +
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP 1329
Query: 619 VQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTAGDENR--------KSLEI 670
Q+ +E+ + + K+ ++ P + P G + S+ G + + E
Sbjct: 1330 DQVEPGKEKTEKEDDKSDTSSSQQPKS---PQGLSDTGYSSDGISSSLGEIPSLIPTDEK 1386
Query: 671 EITGALDEDFTDQLSLMQLPG-----KGDSRNELKVQGPSSKEEKG-RATEAQNTLLES- 723
+I L +D Q S P + + L+ Q + +EK + T+ E
Sbjct: 1387 DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQP 1446
Query: 724 LDEDNSASLKIQLETKEPVTSEEEDESPQE----LAGEGGDQKSPAKKEHNSS------- 772
D++ + SL ET E SEEE + QE + Q P+ K+H
Sbjct: 1447 KDQEKTQSLS---ETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDI 1503
Query: 773 ----VPWSSLEKQMQRDQEPC--SVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQI 826
P+ S+E+ + + P R +V SS +Y QE +EE + QI
Sbjct: 1504 TTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQE---DSQGSGEEEDFIRKQI 1560
Query: 827 AQASGPELCSVSLTSE 842
+ S E S S E
Sbjct: 1561 IEMSADEDASGSEDDE 1576
Score = 43.9 bits (102), Expect = 7e-04
Identities = 109/546 (19%), Positives = 203/546 (37%), Gaps = 53/546 (9%)
Query: 128 TQEKRMLPSGMASSSQLIPEES---GAVGNNRVDPWREAKTHNFPGEASEHNDPKNKHLE 184
++E+R + + S +Q +P+ S A + + +E + + P ++ DP
Sbjct: 49 SEEERRQIAAVMSRAQGLPKGSVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQP 108
Query: 185 GDEQSQEVAQDIQTTEDNEGQLKTNKPMAGS-KKTSSPTERKGQDKEISQEG--DEPARE 241
G +S+ T +E +L P S K++ S T+ K + K G E
Sbjct: 109 GLSKSRTT-----DTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNAL 163
Query: 242 QSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSS 301
+VS + ++F + L + S +E T + + + V+ E+ K I +PPLQ++
Sbjct: 164 SAVSSVVNKFNPFD--LISDSEASQEETTK--KQKVVQKEQGKPEGIIKPPLQQQPPKPI 219
Query: 302 QHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSE 361
+Q R P Q + S +Q+P K Q P K + P
Sbjct: 220 PK----QQGPGRDPLQQDGTPKS------ISSQQPEKIKSQPPGTGKPIQGP-------- 261
Query: 362 TQEKECETKDLPVQY-GSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ 420
TQ + + LP+Q SR ++ +D+ RG + + +P +
Sbjct: 262 TQTPQTDHAKLPLQRDASRPQTKQADIV------RGESVKPSLPSPSKPPIQQPTPGKPP 315
Query: 421 TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF 480
Q +++ Q A+ T+ L+ + G P ++ + A+ A
Sbjct: 316 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGT-VKPPVQPPGTTKPPAQPLGPAKPPAQ 374
Query: 481 VNSKNAPAAERTLGARERTQD----LAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPE 536
P++E+ G + Q P ++ + +P+ ++ G Q
Sbjct: 375 QTGSEKPSSEQP-GPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKA 433
Query: 537 SPFTQS---DEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPD 593
T++ G + P A S+ +TG P + SQ G Q G P
Sbjct: 434 PGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTG--PTKPPSQLPGPAKPPPQQPGPAK-PP 490
Query: 594 TQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHP 653
Q+ G+ ++ + P + + +QP + +Q PG+ P A P
Sbjct: 491 PQQPGSAKPPSQQPGSTKPPPQ-QPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKP 549
Query: 654 EAQEST 659
AQ+ST
Sbjct: 550 SAQQST 555
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 57.4 bits (137), Expect = 6e-08
Identities = 90/441 (20%), Positives = 173/441 (39%), Gaps = 72/441 (16%)
Query: 201 DNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKI-----RDQFGEQE 255
D G K K A +K+ S E++ ++++ S+ G P + S + + E +
Sbjct: 633 DKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGK 692
Query: 256 GNLATQSSPPKEATQRPCEDQEV--RTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAAR 313
+ + S ++A ++ ++E+ + E EK+ N+ + L E+ S H
Sbjct: 693 SDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQM 752
Query: 314 SPSQTQKST--DSKDVCRMFD-----TQEPGKDADQTP------AKTKNLG----EPEDY 356
P +T K +++ + ++F T+E K+A+++P +KTK+L + +
Sbjct: 753 QPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSF 812
Query: 357 GRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLV 416
G+ E E L + N + +S DE Q +++K + +
Sbjct: 813 GQNEAGSEPHIEAHSLELS-SLDNKNFSSATEDE------------IDQCVKEKKLKRKI 859
Query: 417 LETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEG----GDQTHPELEGTAVSGEEAEHT 472
L + + K + G+ + + + + SEG + H E E + AE
Sbjct: 860 LGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESN 919
Query: 473 K---EGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHD-QPVEEED 528
+ + T+E F ++PA E + +D PL +G T V D ++E+D
Sbjct: 920 QCIQQLTSERF----DSPAEETVNIPLKEDEDAMPL----IGPETLVCHEVDLDDLDEKD 971
Query: 529 GYQGED---------------PESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDS 573
ED P P S +P +L+ +E S ++ ++ DS
Sbjct: 972 KTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDS 1031
Query: 574 QSQGDQHG----ESVQGGHNN 590
++ Q G ES G N
Sbjct: 1032 IAEESQEGLCERESANGFETN 1052
Score = 56.2 bits (134), Expect = 1e-07
Identities = 87/444 (19%), Positives = 170/444 (38%), Gaps = 77/444 (17%)
Query: 101 KPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPW 160
K EK+ L++ +A D + + ++ + + S S + I +S G R+
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR-GRRRI--- 473
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
A+ N + E ++K + D ++++V D +T E E +L + +K
Sbjct: 474 --ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 221 PTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPC---EDQE 277
+++ DK+ +E ++ + D GE++ E PC +
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEED-----------EEDMEPCLTGTKVK 580
Query: 278 VRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPG 337
V+ + K I E + KST+ D ++ G
Sbjct: 581 VKYGRGKTQKIYEASI--------------------------KSTEIDDGEVLYLVHYYG 614
Query: 338 KDADQTP-AKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRG 396
+ K + P D G + Q+K+ + K+ SE + RDE
Sbjct: 615 WNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKE---------DSEKDEKRDE------ 659
Query: 397 PEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTH 456
++++ ++ RP + T + + Y GLSK+ ++E S++ SE D
Sbjct: 660 --------ERQKSKRGRPPLKSTLSSNMPY----GLSKTANSEGKSDSCSSDSETEDALE 707
Query: 457 PELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLE--KQSVGENT 514
L +S ++ E + ++ +N + L +RTQ + PLE K VGEN
Sbjct: 708 KNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQPLETLKLEVGENE 766
Query: 515 RVTKTHDQPVEEEDGYQGEDPESP 538
++ + +E+ + + E +SP
Sbjct: 767 QIVQIFGNKMEKTEEVKKEAEKSP 790
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 57.4 bits (137), Expect = 6e-08
Identities = 90/441 (20%), Positives = 173/441 (39%), Gaps = 72/441 (16%)
Query: 201 DNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKI-----RDQFGEQE 255
D G K K A +K+ S E++ ++++ S+ G P + S + + E +
Sbjct: 633 DKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGK 692
Query: 256 GNLATQSSPPKEATQRPCEDQEV--RTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAAR 313
+ + S ++A ++ ++E+ + E EK+ N+ + L E+ S H
Sbjct: 693 SDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQM 752
Query: 314 SPSQTQKST--DSKDVCRMFD-----TQEPGKDADQTP------AKTKNLG----EPEDY 356
P +T K +++ + ++F T+E K+A+++P +KTK+L + +
Sbjct: 753 QPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSF 812
Query: 357 GRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLV 416
G+ E E L + N + +S DE Q +++K + +
Sbjct: 813 GQNEAGSEPHIEAHSLELS-SLDNKNFSSATEDE------------IDQCVKEKKLKRKI 859
Query: 417 LETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEG----GDQTHPELEGTAVSGEEAEHT 472
L + + K + G+ + + + + SEG + H E E + AE
Sbjct: 860 LGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFERENEGMPSLIAESN 919
Query: 473 K---EGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHD-QPVEEED 528
+ + T+E F ++PA E + +D PL +G T V D ++E+D
Sbjct: 920 QCIQQLTSERF----DSPAEETVNIPLKEDEDAMPL----IGPETLVCHEVDLDDLDEKD 971
Query: 529 GYQGED---------------PESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDS 573
ED P P S +P +L+ +E S ++ ++ DS
Sbjct: 972 KTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDS 1031
Query: 574 QSQGDQHG----ESVQGGHNN 590
++ Q G ES G N
Sbjct: 1032 IAEESQEGLCERESANGFETN 1052
Score = 56.2 bits (134), Expect = 1e-07
Identities = 87/444 (19%), Positives = 170/444 (38%), Gaps = 77/444 (17%)
Query: 101 KPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPW 160
K EK+ L++ +A D + + ++ + + S S + I +S G R+
Sbjct: 418 KEEKKDLEESMEEALKLDQEMPLTEVKSEPEENIDSNSESEREEIELKSPR-GRRRI--- 473
Query: 161 REAKTHNFPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSS 220
A+ N + E ++K + D ++++V D +T E E +L + +K
Sbjct: 474 --ARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYETAEKKENELLLGRKNTPKQKEKK 531
Query: 221 PTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGNLATQSSPPKEATQRPC---EDQE 277
+++ DK+ +E ++ + D GE++ E PC +
Sbjct: 532 IKKQEDSDKDSDEEEEKSQEREETESKCDSEGEED-----------EEDMEPCLTGTKVK 580
Query: 278 VRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPG 337
V+ + K I E + KST+ D ++ G
Sbjct: 581 VKYGRGKTQKIYEASI--------------------------KSTEIDDGEVLYLVHYYG 614
Query: 338 KDADQTP-AKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRG 396
+ K + P D G + Q+K+ + K+ SE + RDE
Sbjct: 615 WNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKE---------DSEKDEKRDE------ 659
Query: 397 PEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTH 456
++++ ++ RP + T + + Y GLSK+ ++E S++ SE D
Sbjct: 660 --------ERQKSKRGRPPLKSTLSSNMPY----GLSKTANSEGKSDSCSSDSETEDALE 707
Query: 457 PELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLE--KQSVGENT 514
L +S ++ E + ++ +N + L +RTQ + PLE K VGEN
Sbjct: 708 KNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQ-MQPLETLKLEVGENE 766
Query: 515 RVTKTHDQPVEEEDGYQGEDPESP 538
++ + +E+ + + E +SP
Sbjct: 767 QIVQIFGNKMEKTEEVKKEAEKSP 790
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 56.6 bits (135), Expect = 1e-07
Identities = 87/411 (21%), Positives = 153/411 (37%), Gaps = 49/411 (11%)
Query: 266 KEATQRPCEDQEVRTEKEKHSNIQEP-PLQREDEPSSQHADLPEQAAARSPSQTQKSTDS 324
K+A +R E++ ++ + ++ ++ ++ L ++ + PE+ R S+++ +++
Sbjct: 47 KQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEA 106
Query: 325 KDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTSETQEKECETKDLPVQYGSRNGSET 384
+ G A+ +PAK +N P + E E +DLP Q G + E
Sbjct: 107 SSPDYFGPPAKNGVAAEVSPAKEEN---PRRASKAVEESSDEERQRDLPAQRGEESSEE- 162
Query: 385 SDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSET 444
E K G K + RK +P+V + Q +S+++E
Sbjct: 163 -----EEK-----------GYKGKTRK-KPVVKKQAPGKASVSRKQAREESEESE----- 200
Query: 445 QYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAP 504
+E +T ++EG + E +E E K E + E+ +D
Sbjct: 201 ----AEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQ--REEEVEEEEKEEDE-- 252
Query: 505 LEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSET 564
EK TR EE Q + SD SE A+ G+ S
Sbjct: 253 -EKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSD---SEEEQKEAASSGDDSGRD 308
Query: 565 GELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTED 624
E PVQ S+ + G G + + + +G P K A + + GE+ L +
Sbjct: 309 REPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLERE 368
Query: 625 QEQP-----ARGEHKNQG---PGTKG--PGAAVEPNGHPEAQESTAGDENR 665
+GE KN+ KG ++ +G PEA+ AG R
Sbjct: 369 VSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRR 419
Score = 48.1 bits (113), Expect = 4e-05
Identities = 85/456 (18%), Positives = 177/456 (38%), Gaps = 43/456 (9%)
Query: 88 IKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQWTVGTSPTQEKRMLPSGMASSSQLI-P 146
+K L+ EL ++ E +D G T + P +++ S S S+ P
Sbjct: 50 LKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSP 109
Query: 147 EESGAVGNN----RVDPWREAKTHNFPGEASEHNDPKNKH----LEGDEQSQEVAQDIQT 198
+ G N V P +E E +D + + G+E S+E
Sbjct: 110 DYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEE------- 162
Query: 199 TEDNEGQLKTNK-PMAGSKKTSSPTERKGQDKEISQEGDEPAREQSVSKIRDQFGEQEGN 257
E+ + KT K P+ + + + Q +E S+E + +++ K+ G +
Sbjct: 163 -EEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLK 221
Query: 258 LATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAARSPSQ 317
+ Q S + Q+ + +E E+EK + ++ + + + E+ + + SQ
Sbjct: 222 ESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQ 281
Query: 318 TQK---STDSKDVCRMFDTQEPGKDADQTP---AKTKNLGEPEDYGRTSETQEKECET-K 370
++ +DS++ + + D+ P K+++ + + R S + E E ++ K
Sbjct: 282 AKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGK 341
Query: 371 DLPVQYGSRN----GSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQTQDGKY 426
P GSR GS + + D +E EA G + ++R ++ + +T+
Sbjct: 342 GEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSS- 400
Query: 427 QELQGLSKSKDAEKGSE------------TQYLSSEGGDQTHPELEGTAVSGEEAEHTKE 474
G ++K + GS +Y+ + G + + +L G+ S +E
Sbjct: 401 SSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILR 460
Query: 475 GTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSV 510
EA + K P+ + +E+ ++ A + V
Sbjct: 461 AELEA-LGMKGTPSLGKCRALKEQREEAAEVASLDV 495
Score = 30.8 bits (68), Expect = 5.9
Identities = 53/243 (21%), Positives = 85/243 (34%), Gaps = 40/243 (16%)
Query: 518 KTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQG 577
++H +P E++ + + E Q DE +S +++G P + +
Sbjct: 39 RSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPT----PCSDPERKRF 94
Query: 578 DQHGESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQG 637
+ ES G ++PD P KN V PA +E P R
Sbjct: 95 RFNSESESGSEASSPD---YFGPPAKNGVAAEVSPA----------KEENPRRASK---- 137
Query: 638 PGTKGPGAAVEPNGHPEAQESTAGDENRKSLEIEITGALDEDFTDQLSLMQLPGKGD-SR 696
AVE + E Q +S E E G + + Q PGK SR
Sbjct: 138 --------AVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSR 189
Query: 697 NELK----------VQGPSSKEEKGRATEAQNTLLESLDEDNSASLKIQLETKEPVTSEE 746
+ + VQ + K E + T++ + +E+ A K Q E + +E
Sbjct: 190 KQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKE 249
Query: 747 EDE 749
EDE
Sbjct: 250 EDE 252
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 56.2 bits (134), Expect = 1e-07
Identities = 85/446 (19%), Positives = 165/446 (36%), Gaps = 49/446 (10%)
Query: 253 EQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPSSQHADLPEQAAA 312
E +G+LA +PP E+++ E +V +E++ + + + E S H + A
Sbjct: 32 EWKGHLAQAPTPPLESSESS-EGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGG 90
Query: 313 RSPSQTQKSTDSKDVCRMFDTQEPGKDA-----------DQTPAKTKNLGEPEDYGRTSE 361
S S T K D KD D + G D D+ LG ED T +
Sbjct: 91 FSRS-TGKGGDDKDD----DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ 145
Query: 362 TQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQT 421
E+ Q + SE+ ++ +E + PE + + E +
Sbjct: 146 ASEESAPQGQDSAQDTT---SESRELDNEDRVDSKPEGGDSTQESESEEHW-----VGGG 197
Query: 422 QDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAFV 481
DG+ G + + + + + SE G+ S E E++++ +
Sbjct: 198 SDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNS--AGMKSKESGENSEQANTQDSG 255
Query: 482 NSKNAPAAERTLGARERTQ---DLAPLEKQSVGENTRVTKTHD---------QPVEEEDG 529
S+ R + + R D + L+ + E + T + QP + G
Sbjct: 256 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 315
Query: 530 YQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQGD--SQSQGDQHGESV--- 584
ED + +Q + + + P+S +S+E N SS+ Q + S+S+GD +
Sbjct: 316 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV 375
Query: 585 --QGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKG 642
Q +++ + K+ + E + E + +E+ + E+ + G +
Sbjct: 376 EDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQS 435
Query: 643 PGAAVE---PNGHPEAQESTAGDENR 665
++ E H E +S + D +R
Sbjct: 436 HSSSAESQSEESHSEEDDSDSQDSSR 461
Score = 54.3 bits (129), Expect = 5e-07
Identities = 83/476 (17%), Positives = 181/476 (38%), Gaps = 38/476 (7%)
Query: 168 FPGEASEHNDPKNKHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQ 227
+ SE ++ HL +Q ++++E +EG +++ A + S +G
Sbjct: 22 YQNNESEDSEEWKGHL-----AQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGL 76
Query: 228 DKEISQEGDEPAR--EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKH 285
+ Q A +S K D + E + + ++ P + QE +
Sbjct: 77 GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS 136
Query: 286 SNIQEPPLQREDEPSSQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPA 345
+ +Q +E + Q D +A+ + + D++D R+ E G ++ +
Sbjct: 137 DEDSDDTIQASEESAPQGQD-----SAQDTTSESRELDNED--RVDSKPEGGDSTQESES 189
Query: 346 KTKNLGEPED----YGRTSETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAH- 400
+ +G D +G SE ++ ++ D P S G+ + + + G +
Sbjct: 190 EEHWVGGGSDGESSHGDGSELDDEGMQSDD-PESIRSERGNSRMNSAGMKSKESGENSEQ 248
Query: 401 ----GTAGQKERDRKTRPLVLETQTQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTH 456
+ G + + +R + +++ + + + + + K T+ +S +
Sbjct: 249 ANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQ 308
Query: 457 PELEGTAVSGEEAEHTKEGTAEAFVNSKNAPAAERTLGARERTQDLAPLEKQSV-----G 511
P + G+ E +KE ++ + + P++E + A +Q+ + ++ V G
Sbjct: 309 PRRDS---KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG 365
Query: 512 ENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSETGELPVQG 571
+N T ++ + E+ D + + + E E +S +SE N S E+ E P
Sbjct: 366 DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDE 425
Query: 572 DSQSQG--DQHGESVQG----GHNNNPDTQRQGTPGEKNRALEAVVPAVRGEDVQL 621
+S SQ H S + H+ D+ Q + K + + ED QL
Sbjct: 426 NSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQL 481
Score = 47.8 bits (112), Expect = 5e-05
Identities = 71/355 (20%), Positives = 136/355 (38%), Gaps = 52/355 (14%)
Query: 504 PLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFTQSDEGSSETPNSLASEEGNSSSE 563
P ++Q G N+R+ D +D Q + +P Q + + +T + S E ++
Sbjct: 123 PKDRQE-GGNSRLGSDEDS----DDTIQASEESAP--QGQDSAQDTTSE--SRELDNEDR 173
Query: 564 TGELPVQGDS--QSQGDQH----GESVQGGHNNNPDTQRQGTPGEKNRALEAVVPAVRGE 617
P GDS +S+ ++H G + H + + +G + ++ + RG
Sbjct: 174 VDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSE----RGN 229
Query: 618 DVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQ---ESTAGDENRKSLEIEITG 674
+ + GE+ Q G+ + HP + +S +E+ +S E++
Sbjct: 230 SRMNSAGMKSKESGENSEQANTQDSGGSQLLE--HPSRKIFRKSRISEEDDRS-ELDDNN 286
Query: 675 ALDEDFTDQ----------LSLMQLPGKGDSRNELK----------VQGPSSKEEKGRAT 714
++E +D LS + KGDS+ + K V GPSS+ +
Sbjct: 287 TMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANL 346
Query: 715 EAQNTLLESLDE-------DNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKK 767
+Q ES +E DN +E +E S EED S + ++ A
Sbjct: 347 SSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS 406
Query: 768 EHNSSVPWSSLEKQMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQK 822
E + S+ +S + D+ S E +SS +E ++ + ++ +
Sbjct: 407 ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSR 461
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.123 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,029,081
Number of Sequences: 37866
Number of extensions: 2065314
Number of successful extensions: 11890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 96
Number of HSP's successfully gapped in prelim test: 873
Number of HSP's that attempted gapping in prelim test: 8276
Number of HSP's gapped (non-prelim): 3080
length of query: 904
length of database: 18,247,518
effective HSP length: 111
effective length of query: 793
effective length of database: 14,044,392
effective search space: 11137202856
effective search space used: 11137202856
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.