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Search of human proteins with 55749621
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749621 pleckstrin homology domain containing, family G,
member 3 [Homo sapiens]
(1163 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749621 pleckstrin homology domain containing, family G, mem... 2324 0.0
gi|71274148 pleckstrin homology domain containing, family G (wit... 381 e-105
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 265 1e-70
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 101 4e-21
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 100 6e-21
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 100 1e-20
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 99 2e-20
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 97 1e-19
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 92 2e-18
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 92 2e-18
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 87 1e-16
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 87 1e-16
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 86 2e-16
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 86 2e-16
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 84 6e-16
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 83 2e-15
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 83 2e-15
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 82 2e-15
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 82 3e-15
gi|193211603 pleckstrin homology domain containing, family G (wi... 79 3e-14
gi|193211598 pleckstrin homology domain containing, family G (wi... 79 3e-14
gi|193211596 pleckstrin homology domain containing, family G (wi... 79 3e-14
gi|193211594 pleckstrin homology domain containing, family G (wi... 79 3e-14
gi|55742734 pleckstrin homology domain containing, family G (wit... 79 3e-14
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 76 2e-13
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 76 2e-13
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 76 2e-13
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 76 2e-13
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 74 1e-12
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 73 1e-12
>gi|55749621 pleckstrin homology domain containing, family G, member 3
[Homo sapiens]
Length = 1163
Score = 2324 bits (6022), Expect = 0.0
Identities = 1163/1163 (100%), Positives = 1163/1163 (100%)
Query: 1 MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPN 60
MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPN
Sbjct: 1 MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPN 60
Query: 61 SNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVESQE 120
SNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVESQE
Sbjct: 61 SNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVESQE 120
Query: 121 FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHL 180
FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHL
Sbjct: 121 FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHL 180
Query: 181 LLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD 240
LLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD
Sbjct: 181 LLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD 240
Query: 241 LTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRD 300
LTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRD
Sbjct: 241 LTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRD 300
Query: 301 SLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYY 360
SLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYY
Sbjct: 301 SLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYY 360
Query: 361 PNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESE 420
PNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESE
Sbjct: 361 PNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESE 420
Query: 421 SSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTE 480
SSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTE
Sbjct: 421 SSRSSRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTE 480
Query: 481 SPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPP 540
SPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPP
Sbjct: 481 SPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPP 540
Query: 541 SVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGS 600
SVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGS
Sbjct: 541 SVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGS 600
Query: 601 ATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLL 660
ATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLL
Sbjct: 601 ATDSLSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLL 660
Query: 661 LDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQ 720
LDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQ
Sbjct: 661 LDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQ 720
Query: 721 VGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQ 780
VGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQ
Sbjct: 721 VGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQ 780
Query: 781 ANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQ 840
ANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQ
Sbjct: 781 ANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQ 840
Query: 841 GELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAP 900
GELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAP
Sbjct: 841 GELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAP 900
Query: 901 ERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFF 960
ERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFF
Sbjct: 901 ERDGKSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFF 960
Query: 961 FNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPV 1020
FNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPV
Sbjct: 961 FNPSAVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPV 1020
Query: 1021 NRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADL 1080
NRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADL
Sbjct: 1021 NRSHSVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADL 1080
Query: 1081 TLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDP 1140
TLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDP
Sbjct: 1081 TLEDNRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDP 1140
Query: 1141 ADPSQQGRVRNLREKFQALNSVG 1163
ADPSQQGRVRNLREKFQALNSVG
Sbjct: 1141 ADPSQQGRVRNLREKFQALNSVG 1163
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 381 bits (978), Expect = e-105
Identities = 291/801 (36%), Positives = 379/801 (47%), Gaps = 192/801 (23%)
Query: 14 ERPVSLTSTTSSSGSSCDSR----SAMEEPSSSEA-----------------PAKNGAGS 52
+RPVS ST SSS SS DS S M S+S PA+ + S
Sbjct: 7 DRPVSFGST-SSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSS 65
Query: 53 LRSRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGP-------AHHKLSYLGRVVREIVETE 105
R P + ++ + + P + + + P KL Y+ RVV+EI+ETE
Sbjct: 66 ELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETE 125
Query: 106 RMYV---------------------------------------------QDLRS------ 114
R YV QDL +
Sbjct: 126 RTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPV 185
Query: 115 ------IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYL 168
+ +S+EF IYTQYC NYP SVA LTECMR+K AKFFR+RQE L+HSLPLGSYL
Sbjct: 186 AIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYL 245
Query: 169 LKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQE 228
LKPVQRILKYHLLL EI H D++ +G++VV DAIDTM VAW+INDMKR+HEHAVRLQE
Sbjct: 246 LKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQE 305
Query: 229 IQSLLINWKGPDLTTYGELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIP 288
IQSLL NWKGPDLT+YGELVLEGTFR+ R +NERT FLFDK LLITKKR D F YK +I
Sbjct: 306 IQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHIL 365
Query: 289 CSSLMLIE-STRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQ 347
C +LML+E ++ L F+V HYK+ K Q+++QAK+ ++KR W H+KRLILENH A IP
Sbjct: 366 CGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPA 425
Query: 348 KAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKAR 407
KAK+AILEMD+ + + SPE KA E S R RR+SEP+ + L
Sbjct: 426 KAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRL-RRKSEPSSRSHKVLKTSET 484
Query: 408 AAGMKGKGRRESESSRSSRRPS----GRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEV 463
A ++ R E SS RPS P+S+ + +L + D + Q +
Sbjct: 485 AQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQI--RQAL 542
Query: 464 FSAVEGPSAEETPSDTESPEVLETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEE 523
F + P E D D FV + S+ DL
Sbjct: 543 FPSRRSPQENEDDED------------------------DYQMFVPSFSSSDL------- 571
Query: 524 EEEMGGAAQEPESLLPPSVLDQASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSS 583
++ + E SS + Q +S + R+V R+S
Sbjct: 572 ---------------------NSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRAS 610
Query: 584 SVLSLEGSEKGLARHGSATDSLSCQLSPEVDISVGV-ATEDSPSVNGMEPPSP-GCPVEP 641
SA +S +C PE+ S ++SP G E +P G +E
Sbjct: 611 ----------------SAGESNTC--PPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIE- 651
Query: 642 DRSSCKKKESALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRF 701
L +D I Y+N + D V +RE P R+S+
Sbjct: 652 -----------------LTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVR-- 692
Query: 702 NSLPRPDPEPVPPVGSKRQVG 722
P+ PE +KRQ G
Sbjct: 693 ---PKSTPE---LAFTKRQAG 707
Score = 42.0 bits (97), Expect = 0.003
Identities = 48/187 (25%), Positives = 79/187 (42%), Gaps = 17/187 (9%)
Query: 863 SERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDGKSPTVPCLQEEAGEPLGG 922
+++ K++V+ +ARQYS +IK ++ L+ E+ + KS + ++ L
Sbjct: 969 TDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKS-----MHKDLAAILEE 1023
Query: 923 KGKRKPVLS--LFDYEQLMAQ---EHSPPKPSSAGEMSPQRFFFNPSAVSQRTTSPGGRP 977
K + P + + +Y QL Q SP K G SPQ S + G
Sbjct: 1024 KKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDW 1083
Query: 978 SARSPLSPTE--TFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSHSVPENMVEPPL 1035
S S E F P ++L S+Y + + ++ PR ++ + SVP PL
Sbjct: 1084 LLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKS---TPR--QLSAACSVPSLQTSDPL 1138
Query: 1036 SGRVGRC 1042
G V RC
Sbjct: 1139 PGSVQRC 1145
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 265 bits (678), Expect = 1e-70
Identities = 283/989 (28%), Positives = 405/989 (40%), Gaps = 247/989 (24%)
Query: 27 GSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPNSNNN----------SSSWLNVKGPLS 76
G+ C++R+A P++ + G+GS S S + +S + GP
Sbjct: 29 GTVCETRTA---PAAPTMASPRGSGSSTSLSTVGSEGDPAPGPTPACSASRPEPLPGPPI 85
Query: 77 PFNSRAAAGPAHHKLSYLGRVVREIVETERMY---------------------------- 108
+ P + S L RV REIVETER Y
Sbjct: 86 RLHLSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQV 145
Query: 109 -----------------VQDLRS-----------IVESQEFDIYTQYCNNYPNSVAALTE 140
++DL + + S++FDIYT YC NYP+S+A L E
Sbjct: 146 GTLFANIEDIYEFSSELLEDLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRE 205
Query: 141 CMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED--GFEV 198
A + ++RQ L+HSLPL S+LLKPVQRILKYHLLLQE+ KH+ E G E+
Sbjct: 206 LSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREM 265
Query: 199 VEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVH-- 256
VE+AI +MT VAWYINDMKR+ EHA RLQE+Q L W GP+L+ +GELVLEG FR
Sbjct: 266 VEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGG 325
Query: 257 ---RVRN-ERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHS 312
R+R ER FLF + LL+ K+RG + YKG+I C +L + ES RD L F V+
Sbjct: 326 GGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHIFCCNLSVSESPRDPLGFKVSDLTIP 385
Query: 313 KQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPER-- 370
K ++ +QAK EEKR W H ++RL ENH A+IP KAK+ +LE N C+P+
Sbjct: 386 KHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLE------NSLHCAPKSKP 439
Query: 371 -----LKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRSS 425
S + + + GRR + P+ + +GRR+SE +
Sbjct: 440 VLEPLTPPLGSPRPRDARSFTPGRRNTAPSP-----------GPSVIRRGRRQSEPVKD- 487
Query: 426 RRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTESPEVL 485
P P + + AGSE E++ P ++ S + PE L
Sbjct: 488 --PYVMFPQNAKPGFK--------------HAGSEGELYP----PESQPPVSGSAPPEDL 527
Query: 486 ETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQE-PESLLPPSVLD 544
E DA G +DP G + + E L+ L+ + G + + P+ V
Sbjct: 528 E---DA--GPPTLDPSGTSI------TEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPG 576
Query: 545 QASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLS-LEGSEKGLARHGSATD 603
+ + + + S R S +E+ + G + R S L LEG E +A +
Sbjct: 577 DSETLTFQALPS---RDSSEEEEEEEEGL---EMDERGPSPLHVLEGLESSIA---AEMP 627
Query: 604 SLSCQLS-------PEVDISVGVATEDS-PSVNGME-----PPSPGCPVEPDRSSCKKKE 650
S+ C PE+ + PS++ + P P P P+ S
Sbjct: 628 SIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIPSVPNTPS----- 682
Query: 651 SALSTRDRLLLDKIKSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPE 710
LS+ L D S+ + A RRE S G + S + P D E
Sbjct: 683 --LSSTPTLSCD---SWLQGPLQEPAEAPATRRELFSGSNPGKLGEPPSGGKAGPEEDEE 737
Query: 711 PVPPVGSKRQVGSRPTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGG 770
V S+ F+ +Q +G P ++ FR SEI W+ +E
Sbjct: 738 GV--------------SFTDFQPQDVTQH-QGFPDELA---FRSCSEIRSAWQALE---- 775
Query: 771 SPGKGPGQGQANGFDLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKE 830
QGQ EPL ILE+ +LG + +P
Sbjct: 776 -------QGQLARPGFPEPLLILEDSDLGGDSGSGKAGAPS------------------- 809
Query: 831 LVKELSSSTQGELVAPLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMAR 890
SER ++V +LAR YS RI+ + R
Sbjct: 810 --------------------------------SERTASRVRELARLYSERIQQMQRAETR 837
Query: 891 PPLQWEKVAPERDGKSPTVPCLQEEAGEP 919
+ P + PCL +E EP
Sbjct: 838 ASANAPRRRPRVLAQPQPSPCLPQEQAEP 866
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 101 bits (252), Expect = 4e-21
Identities = 89/314 (28%), Positives = 148/314 (47%), Gaps = 36/314 (11%)
Query: 105 ERMYVQDLRS--IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQH-- 160
ER ++ +L + + +F IY++YCNN+PN+ L+ + + FF + LLQ
Sbjct: 354 ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFF-EACRLLQKMI 412
Query: 161 SLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRH 220
+ L +LL PVQ+I KY L L E+ K+ + F+ VE A+ M VA IN+ KRR
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472
Query: 221 EHAVRLQEIQSLLINWKGPD-LTTYGELVLEGTF-RVHRVR---NERTFFLFDKTLLITK 275
E+ ++ + QS + +W+G D L EL+ G RV + + +R FFLFD L+ K
Sbjct: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532
Query: 276 K---RGDHFVYKGNIPCSSLMLI--ESTRD-SLCFTV-----THYKHSKQQYSIQAKTVE 324
K R D YKG + L ++ E +D L ++ H + + + + E
Sbjct: 533 KDLLRRDVLYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPE 592
Query: 325 EKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSSQDEVSTN 384
+K+ W +K E + Q+ +I E+ +R + ++ + T
Sbjct: 593 QKQRW---LKAFAREREQVQLDQETGFSITEL------------QRKQAMLNASKQQVTG 637
Query: 385 VRQGRRQSEPTKHL 398
+GRR + P L
Sbjct: 638 KPKGRRTAAPPPRL 651
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 100 bits (250), Expect = 6e-21
Identities = 72/227 (31%), Positives = 118/227 (51%), Gaps = 19/227 (8%)
Query: 121 FDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQH-SLPLGSYLLKPVQRILKYH 179
F IY++YCNN+ ++ L++ M+D + FF + L Q + + +LL PVQ+I KY
Sbjct: 191 FWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYP 250
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
L L E+ K+ ++ + V A+ M V IN+ KRR E+ ++ + Q+ +++W+G
Sbjct: 251 LQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGE 310
Query: 240 D-LTTYGELVLEG----TFRVHRVRNERTFFLFDKTLLITKK---RGDHFVYKGNIPCS- 290
D L EL+ G ++ + +R FFLFD +++ KK R D YKG I
Sbjct: 311 DILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDK 370
Query: 291 -SLMLIESTRDSLCFTVT-------HYKHSKQQYSIQAKTVEEKRNW 329
++ IE RD F V+ H K +++ + AK +EEK W
Sbjct: 371 YEVVDIEDGRDD-DFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRW 416
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 100 bits (248), Expect = 1e-20
Identities = 70/204 (34%), Positives = 109/204 (53%), Gaps = 13/204 (6%)
Query: 105 ERMYVQDLRS--IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQH-- 160
ER ++ +L + + +F IY++YCNN+PN+ L+ + + FF + LLQ
Sbjct: 354 ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFF-EACRLLQKMI 412
Query: 161 SLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRH 220
+ L +LL PVQ+I KY L L E+ K+ + F+ VE A+ M VA IN+ KRR
Sbjct: 413 DISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRL 472
Query: 221 EHAVRLQEIQSLLINWKGPD-LTTYGELVLEGTF-RVHRVR---NERTFFLFDKTLLITK 275
E+ ++ + QS + +W+G D L EL+ G RV + + +R FFLFD L+ K
Sbjct: 473 ENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCK 532
Query: 276 K---RGDHFVYKGNIPCSSLMLIE 296
K R D YKG + L +++
Sbjct: 533 KDLLRRDVLYYKGRLDMDGLEVVD 556
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 99.4 bits (246), Expect = 2e-20
Identities = 75/250 (30%), Positives = 116/250 (46%), Gaps = 35/250 (14%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQEL---LQHSLPLGSYLLKPVQRIL 176
+F +Y +YC+N+ ++ L E + F L +PL YLL P+QRI
Sbjct: 141 KFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRIC 200
Query: 177 KYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINW 236
KY LLL+E+AK + V+ A+ M V IN+ KR+ E L+++QS + W
Sbjct: 201 KYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGW 260
Query: 237 KGPDLTTY-GELVLEGTFRVHRVRN--ERTFFLFDKTLLITKKR---------------- 277
+G +LT +L+L+GT N ER FFLFD L+ K++
Sbjct: 261 EGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSI 320
Query: 278 -GDHFVYKGNIPCSSLMLIESTRDSLC------FTVT-----HYKHSKQQYSIQAKTVEE 325
G ++++G I + +M +E+ D +TVT H + + AKT EE
Sbjct: 321 NGSLYIFRGRIN-TEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEE 379
Query: 326 KRNWTHHIKR 335
K+ W I R
Sbjct: 380 KQKWLDAIIR 389
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 96.7 bits (239), Expect = 1e-19
Identities = 75/264 (28%), Positives = 121/264 (45%), Gaps = 32/264 (12%)
Query: 98 VREIVETERMYVQDLRSIVESQE----------------FDIYTQYCNNYPNSVAALTEC 141
+ +I + +R +++DL +E F IY++YCNN+P + L
Sbjct: 289 IEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANL 348
Query: 142 MRDKQQAKFFRDRQELLQH-SLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVE 200
M+ + FF + L Q + + +LL PVQ+I KY L L E+ K+ +E + ++
Sbjct: 349 MKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIK 408
Query: 201 DAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD-LTTYGELVLEG---TFRVH 256
A + M VA IN+ KR+ E ++ Q ++ W+G D L EL+ G
Sbjct: 409 AAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQ 468
Query: 257 RVRNERTFFLFDKTLLITKK---RGDHFVYKGNIPCSSLMLIE--STRDSLC-FTVTH-- 308
+RTFFLFD L+ KK R D YKG + + L++ RD C +V +
Sbjct: 469 GKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAF 528
Query: 309 ---YKHSKQQYSIQAKTVEEKRNW 329
+ + + Y AK E+K W
Sbjct: 529 KLVSRTTDEVYLFCAKKQEDKARW 552
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 42/277 (15%)
Query: 119 QEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKY 178
++F IY +YC N P S + +C FF++ Q L H L L SYLLKPVQRI KY
Sbjct: 746 EDFQIYEKYCQNKPRSESLWRQC----SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKY 801
Query: 179 HLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKG 238
LLL+E+ K + +G E +++A+ ++ + +ND + + I
Sbjct: 802 QLLLKEMLK-YSRNCEGAEDLQEALSSILGILKAVND------------SMHLIAITGYD 848
Query: 239 PDLTTYGELVLEGTFRV---HRVRN------------ERTFFLFDKTLLITKKRGDH--- 280
+L G+L+++G+F V H+ + +R FL +K +L KKR ++
Sbjct: 849 GNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEG 908
Query: 281 ------FVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
+ YK ++ +++ + E+ + Y ++ Y +QA T E K W + I+
Sbjct: 909 YEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIR 968
Query: 335 RLILENHHATIPQKAKEAILEMDSY-YPNRYRCSPER 370
+++ A A+ + S P SP R
Sbjct: 969 KVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSR 1005
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/277 (26%), Positives = 126/277 (45%), Gaps = 42/277 (15%)
Query: 119 QEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKY 178
++F IY +YC N P S + +C FF++ Q L H L L SYLLKPVQRI KY
Sbjct: 693 EDFQIYEKYCQNKPRSESLWRQC----SDCPFFQECQRKLDHKLSLDSYLLKPVQRITKY 748
Query: 179 HLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKG 238
LLL+E+ K + +G E +++A+ ++ + +ND + + I
Sbjct: 749 QLLLKEMLK-YSRNCEGAEDLQEALSSILGILKAVND------------SMHLIAITGYD 795
Query: 239 PDLTTYGELVLEGTFRV---HRVRN------------ERTFFLFDKTLLITKKRGDH--- 280
+L G+L+++G+F V H+ + +R FL +K +L KKR ++
Sbjct: 796 GNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGEG 855
Query: 281 ------FVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
+ YK ++ +++ + E+ + Y ++ Y +QA T E K W + I+
Sbjct: 856 YEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIR 915
Query: 335 RLILENHHATIPQKAKEAILEMDSY-YPNRYRCSPER 370
+++ A A+ + S P SP R
Sbjct: 916 KVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSR 952
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/265 (27%), Positives = 120/265 (45%), Gaps = 32/265 (12%)
Query: 96 RVVREIVETERMYVQDLRS--IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRD 153
+VV E + E Q++ + + +F IY +YC+N+ + L E + + F +
Sbjct: 89 KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLN 148
Query: 154 RQEL---LQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVA 210
L +PL YL+ P+QRI KY L+L+E+ K + + V +A+ M V
Sbjct: 149 CMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVC 208
Query: 211 WYINDMKRRHEHAVRLQEIQSLLINWKGPDLT-TYGELVLEGTFRVHRVRN--ERTFFLF 267
IN+ KR+ E L+E QS + W+G ++T T E+++ G N ER FFLF
Sbjct: 209 SNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLF 268
Query: 268 DKTLLITKKR------------GDHFVYKGNIPCSSLMLIESTRDSLCFTVT-------- 307
D L+ K++ G ++++G I + +M +E+ D +
Sbjct: 269 DNLLVYCKRKHRRLKNSKASTDGHRYLFRGRIN-TEVMEVENVDDGTADFHSSGHIVVNG 327
Query: 308 ---HYKHSKQQYSIQAKTVEEKRNW 329
H + + AKT EEK W
Sbjct: 328 WKIHNTAKNKWFVCMAKTPEEKHEW 352
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/265 (27%), Positives = 120/265 (45%), Gaps = 32/265 (12%)
Query: 96 RVVREIVETERMYVQDLRS--IVESQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRD 153
+VV E + E Q++ + + +F IY +YC+N+ + L E + + F +
Sbjct: 89 KVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLN 148
Query: 154 RQEL---LQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVA 210
L +PL YL+ P+QRI KY L+L+E+ K + + V +A+ M V
Sbjct: 149 CMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVC 208
Query: 211 WYINDMKRRHEHAVRLQEIQSLLINWKGPDLT-TYGELVLEGTFRVHRVRN--ERTFFLF 267
IN+ KR+ E L+E QS + W+G ++T T E+++ G N ER FFLF
Sbjct: 209 SNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLF 268
Query: 268 DKTLLITKKR------------GDHFVYKGNIPCSSLMLIESTRDSLCFTVT-------- 307
D L+ K++ G ++++G I + +M +E+ D +
Sbjct: 269 DNLLVYCKRKHRRLKNSKASTDGHRYLFRGRIN-TEVMEVENVDDGTADFHSSGHIVVNG 327
Query: 308 ---HYKHSKQQYSIQAKTVEEKRNW 329
H + + AKT EEK W
Sbjct: 328 WKIHNTAKNKWFVCMAKTPEEKHEW 352
>gi|153791628 MCF.2 cell line derived transforming sequence isoform
a [Homo sapiens]
Length = 985
Score = 86.3 bits (212), Expect = 2e-16
Identities = 68/257 (26%), Positives = 117/257 (45%), Gaps = 43/257 (16%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y +YC N P S R + FF++ Q L+H L L SYLLKPVQRI KY
Sbjct: 644 DFQMYAKYCQNKPRSETI----WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQ 699
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLL+E+ K + ++ +G +++ A+D M + +ND + + IN
Sbjct: 700 LLLKELLK-YSKDCEGSALLKKALDAMLDLLKSVND------------SMHQIAINGYIG 746
Query: 240 DLTTYGELVLEGTFRV---HR------------VRNERTFFLFDKTLLITKKR------G 278
+L G+++++G F V H+ +R FL++K ++ K+R
Sbjct: 747 NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGS 806
Query: 279 DHFVYKGNIPCSSLMLIESTR----DSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
D + C + + T D+ F + Y ++ Y +QA V+ K W I+
Sbjct: 807 DRYPSYSFKHCWKMDEVGITEYVKGDNRKFEI-WYGEKEEVYIVQASNVDVKMTWLKEIR 865
Query: 335 RLILENHHATIPQKAKE 351
++L+ +K K+
Sbjct: 866 NILLKQQELLTVKKRKQ 882
>gi|153791325 MCF.2 cell line derived transforming sequence isoform
b [Homo sapiens]
Length = 925
Score = 86.3 bits (212), Expect = 2e-16
Identities = 68/257 (26%), Positives = 117/257 (45%), Gaps = 43/257 (16%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y +YC N P S R + FF++ Q L+H L L SYLLKPVQRI KY
Sbjct: 584 DFQMYAKYCQNKPRSETI----WRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQ 639
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLL+E+ K + ++ +G +++ A+D M + +ND + + IN
Sbjct: 640 LLLKELLK-YSKDCEGSALLKKALDAMLDLLKSVND------------SMHQIAINGYIG 686
Query: 240 DLTTYGELVLEGTFRV---HR------------VRNERTFFLFDKTLLITKKR------G 278
+L G+++++G F V H+ +R FL++K ++ K+R
Sbjct: 687 NLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGS 746
Query: 279 DHFVYKGNIPCSSLMLIESTR----DSLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIK 334
D + C + + T D+ F + Y ++ Y +QA V+ K W I+
Sbjct: 747 DRYPSYSFKHCWKMDEVGITEYVKGDNRKFEI-WYGEKEEVYIVQASNVDVKMTWLKEIR 805
Query: 335 RLILENHHATIPQKAKE 351
++L+ +K K+
Sbjct: 806 NILLKQQELLTVKKRKQ 822
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 84.3 bits (207), Expect = 6e-16
Identities = 67/248 (27%), Positives = 119/248 (47%), Gaps = 36/248 (14%)
Query: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLK-----PVQRILK 177
IY +YC++ ++ L + + ++ FR + E + G + L+ P+QR+LK
Sbjct: 277 IYGEYCSHMEHAQNTLNQLLASRED---FRQKVEECTLKVQDGKFKLQDLLVVPMQRVLK 333
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
YHLLL+E+ H E + + +++A++ M +A YIN++KR E ++ E QS + N +
Sbjct: 334 YHLLLKELLSHSAERPER-QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQ 392
Query: 238 GPDLTTYGELVLEGTFRVHRVRN----ERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLM 293
L +G ++G +V + N +R FLFDK +++ K++G + K I L+
Sbjct: 393 -VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEII---ELL 448
Query: 294 LIESTRD----------SLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILE---- 339
+ T D S F + H + KQ + KT + KR W + +
Sbjct: 449 FHKMTDDPMNNKDVKKWSYGFYLIHLQ-GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPD 507
Query: 340 ----NHHA 343
NHH+
Sbjct: 508 KANANHHS 515
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 82.8 bits (203), Expect = 2e-15
Identities = 65/236 (27%), Positives = 111/236 (47%), Gaps = 34/236 (14%)
Query: 118 SQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 177
+ +F +Y YC N P+S + E +F + Q+ + + SYL+KPVQRI K
Sbjct: 1377 ADKFQMYVTYCKNKPDSTQLILE-----HAGSYFDEIQQRHGLANSISSYLIKPVQRITK 1431
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
Y LLL+E+ E+G ++D ++ M V ND A+ L ++
Sbjct: 1432 YQLLLKELLTCC---EEGKGEIKDGLEVMLSVPKRAND-------AMHLSMLEGF----- 1476
Query: 238 GPDLTTYGELVLEGTFRVH------RVRNERTFFLFDKTLLITKKRGD-----HFVYKGN 286
++ + GEL+L+ +F+V R ER FLF+ +L+ +K+ D ++YK
Sbjct: 1477 DENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSK 1536
Query: 287 IPCSSLMLIESTRDSLC---FTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILE 339
+ S L + E C V S + ++A ++E K++W HI+ +I E
Sbjct: 1537 LFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQE 1592
Score = 82.0 bits (201), Expect = 3e-15
Identities = 101/406 (24%), Positives = 168/406 (41%), Gaps = 93/406 (22%)
Query: 9 QDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLR----SRHLPNSNNN 64
QD + + T+S + S+ + SA+EE S+ ++ SL P+ N +
Sbjct: 1886 QDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPS 1945
Query: 65 SSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVES------ 118
+S L+ P+ R ++ L V++E+VETER YV+DL +VE
Sbjct: 1946 DNSLLSSSSPIDEMEERKSSS-----LKRRHYVLQELVETERDYVRDLGYVVEGYMALMK 2000
Query: 119 --------------------QEFDIYTQY-------CNNYPNSVAAL------------- 138
Q +D + + C P + +L
Sbjct: 2001 EDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIA 2060
Query: 139 -------TECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDE 191
+E + + FF D ++ L H L L L+KPVQRI+KY LLL++ K+ +
Sbjct: 2061 YCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKK 2120
Query: 192 EEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEG 251
+E A++ M V NDM + RLQ ++ G+L+L+
Sbjct: 2121 ASLDTSELERAVEVMCIVPRRCNDMM----NVGRLQGFDGKIV--------AQGKLLLQD 2168
Query: 252 TFRV--------HRVRNERTFFLFDKTLL----ITKKRG---DHFVYKGNIPCSSLMLIE 296
TF V R R ER FLF++ ++ + KK+G F++K +I S L L E
Sbjct: 2169 TFLVTDQDAGLLPRCR-ERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEE 2227
Query: 297 STRDSLC-FTVTHYKHS-KQQYSIQAKTVEEKRNWTHHIKRLILEN 340
+ + C F +T + + + + + ++ W H I + ILEN
Sbjct: 2228 NVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQ-ILEN 2272
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 82.8 bits (203), Expect = 2e-15
Identities = 63/249 (25%), Positives = 116/249 (46%), Gaps = 33/249 (13%)
Query: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLK-----PVQRILK 177
IY +YC++ ++ L + + ++ FR + E + G + L+ P+QR+LK
Sbjct: 282 IYGEYCSHMEHAQNTLNQLLASRED---FRQKVEECTLKVQDGKFKLQDLLVVPMQRVLK 338
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
YHLLL+E+ H E + + +++A++ M +A YIN++KR E ++ E QS + N +
Sbjct: 339 YHLLLKELLSHSAERPER-QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQ 397
Query: 238 GPDLTTYGELVLEGTFRVHRVRN----ERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLM 293
L +G ++G +V + N +R FLFDK +++ K++G + K I
Sbjct: 398 -VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHK 456
Query: 294 LIESTRDSLCFTVTHYK-----------HSKQQYSIQAKTVEEKRNWTHHIKRLILE--- 339
+ + ++ +H K KQ + KT + KR W + +
Sbjct: 457 MTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKP 516
Query: 340 -----NHHA 343
NHH+
Sbjct: 517 DKANANHHS 525
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 82.4 bits (202), Expect = 2e-15
Identities = 67/231 (29%), Positives = 107/231 (46%), Gaps = 14/231 (6%)
Query: 119 QEFDIYTQYCNNYPNSVAALTE--CMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRIL 176
+ F +Y +YC+ ++ L R+ Q K Q L L+ P+QR+L
Sbjct: 275 ERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL 334
Query: 177 KYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINW 236
KYHLLLQE+ KH E + E + A+D M +A +N++KR +E ++ Q L I
Sbjct: 335 KYHLLLQELVKHTQEAMEK-ENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-LSIEN 392
Query: 237 KGPDLTTYGELVLEGTFRV----HRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSL 292
L YG ++G ++ R + +R FL DK LLI K+RGD + K + S
Sbjct: 393 LDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSF 452
Query: 293 MLIEST---RDSLCFT---VTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
+ + + RD+ ++ + Q Y + KT E K+ W + I
Sbjct: 453 QVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAI 503
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 82.0 bits (201), Expect = 3e-15
Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 16/220 (7%)
Query: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDR--QELLQHSLPLGSYLLKPVQRILKYHL 180
IY QYC+ +++++L + K+ K + + L L+ P+QR+LKYHL
Sbjct: 277 IYGQYCSGVESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHL 336
Query: 181 LLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPD 240
LLQE+ KH + + ++ A+D M +A Y+N++KR +E +++ Q + N P
Sbjct: 337 LLQELVKHTTDPTEKAN-LKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPV 395
Query: 241 LTTYGELVLEGTFRV----HRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLI- 295
L +G +G R+ + ER FLFD +++ K++GD++ K I +
Sbjct: 396 L-LFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIAN 454
Query: 296 ------ESTRDSLCFTVTHYKHSKQQYSIQAKTVEEKRNW 329
E+ + S F + H + KT + K+ W
Sbjct: 455 NPTTDKENKKWSYGFYLIH-TQGQNGLEFYCKTKDLKKKW 493
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 736 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 790
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 791 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 839
Query: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 840 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 898
Query: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 899 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 945
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 817 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 871
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 872 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 920
Query: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 921 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 979
Query: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 980 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 817 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 871
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 872 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 920
Query: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 921 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 979
Query: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 980 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 817 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 871
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 872 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 920
Query: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 921 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 979
Query: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 980 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 79.0 bits (193), Expect = 3e-14
Identities = 68/227 (29%), Positives = 107/227 (47%), Gaps = 26/227 (11%)
Query: 120 EFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYH 179
+F +Y Y N P S A ++ FF+D+Q+ L L L SYLLKP+QR+ KY
Sbjct: 817 QFGMYALYSKNKPRSDALMSSYGHT-----FFKDKQQALGDHLDLASYLLKPIQRMGKYA 871
Query: 180 LLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGP 239
LLLQE+A+ + +A + + ND+ + + IQ +N
Sbjct: 872 LLLQELARACGGPTQELSALREAQSLVHFQLRHGNDL-------LAMDAIQGCDVN---- 920
Query: 240 DLTTYGELVLEGTF--RVHRVRNERTFFLFDKTLLITKKRG-----DHFVYKGNIPCSSL 292
L G+LV + F R R ++ R FLF++ LL +K R D F YK + + L
Sbjct: 921 -LKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADL 979
Query: 293 MLIESTRDS-LCFTV-THYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337
L E +S L F + + ++ + +QA ++ K+ WT I L+
Sbjct: 980 GLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLL 1026
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 76.3 bits (186), Expect = 2e-13
Identities = 67/236 (28%), Positives = 107/236 (45%), Gaps = 34/236 (14%)
Query: 118 SQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 177
+ +F +Y YC N P+S + E FF + Q+ + + SYL+KPVQRI K
Sbjct: 1366 ADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLANSISSYLIKPVQRITK 1420
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
Y LLL+E+ E+G ++D ++ M V ND H L+
Sbjct: 1421 YQLLLKELLTCC---EEGKGELKDGLEVMLSVPKKANDAM----HVSMLEGFDE------ 1467
Query: 238 GPDLTTYGELVLEGTFRVH------RVRNERTFFLFDKTLLITKKRGD-----HFVYKGN 286
+L GEL+L+ F+V R ER FLF+ +L+ +K+ D +VYK
Sbjct: 1468 --NLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNK 1525
Query: 287 IPCSSLMLIESTRDSLC-FTVTHYK--HSKQQYSIQAKTVEEKRNWTHHIKRLILE 339
+ S L + E C F + + S + ++A +E K+ W +I+ +I E
Sbjct: 1526 LLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQE 1581
Score = 73.6 bits (179), Expect = 1e-12
Identities = 68/263 (25%), Positives = 124/263 (47%), Gaps = 37/263 (14%)
Query: 89 HKLSYLGRVVREIVETERMYVQDLRSIVESQEFDIYTQYCNNYPNSVAALTECMRDKQQA 148
HK +L + + I E +R+ ++ ++ IY YC N P S + E A
Sbjct: 1986 HKDFFLAELEKCIQEQDRLAQLFIK---HERKLHIYVWYCQNKPRSEYIVAE-----YDA 2037
Query: 149 KFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEV--VEDAIDTM 206
F +QE+ Q L L +L+KP+QRI KY LLL++ ++ E+ G E +E A++ M
Sbjct: 2038 YFEEVKQEINQR-LTLSDFLIKPIQRITKYQLLLKDFLRY--SEKAGLECSDIEKAVELM 2094
Query: 207 TCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVHRV-------R 259
V NDM + RLQ + LT G+L+ + TF V +
Sbjct: 2095 CLVPKRCNDMM----NLGRLQGFEG--------TLTAQGKLLQQDTFYVIELDAGMQSRT 2142
Query: 260 NERTFFLFDKTLLITK--KRGD---HFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQ 314
ER FLF++ ++ ++ ++G +++K +I + L+L E+ + C + + +
Sbjct: 2143 KERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSE 2202
Query: 315 QYSIQAKTVEEKRNWTHHIKRLI 337
+ +QA + ++ W I +++
Sbjct: 2203 RVVLQAANADIQQAWVQDINQVL 2225
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 76.3 bits (186), Expect = 2e-13
Identities = 67/236 (28%), Positives = 107/236 (45%), Gaps = 34/236 (14%)
Query: 118 SQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 177
+ +F +Y YC N P+S + E FF + Q+ + + SYL+KPVQRI K
Sbjct: 1366 ADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLANSISSYLIKPVQRITK 1420
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237
Y LLL+E+ E+G ++D ++ M V ND H L+
Sbjct: 1421 YQLLLKELLTCC---EEGKGELKDGLEVMLSVPKKANDAM----HVSMLEGFDE------ 1467
Query: 238 GPDLTTYGELVLEGTFRVH------RVRNERTFFLFDKTLLITKKRGD-----HFVYKGN 286
+L GEL+L+ F+V R ER FLF+ +L+ +K+ D +VYK
Sbjct: 1468 --NLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYVYKNK 1525
Query: 287 IPCSSLMLIESTRDSLC-FTVTHYK--HSKQQYSIQAKTVEEKRNWTHHIKRLILE 339
+ S L + E C F + + S + ++A +E K+ W +I+ +I E
Sbjct: 1526 LLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQE 1581
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b
[Homo sapiens]
Length = 626
Score = 76.3 bits (186), Expect = 2e-13
Identities = 87/357 (24%), Positives = 146/357 (40%), Gaps = 42/357 (11%)
Query: 118 SQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 177
+ F +Y+ +C N+ L DK F R QHS L SYL+KPVQR+LK
Sbjct: 120 ADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLK 179
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEH--AVRLQEIQSLLIN 235
Y LLL+E+ D+E + + +A+ M VA +IN+M++ +E V Q +
Sbjct: 180 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 239
Query: 236 WKGPDLTTYGELVLEGT-------FRVHRVRN--ERTFFLFDKTLLITKKRG-------- 278
K + GEL++ T + + R E T F+F + +++ K
Sbjct: 240 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLP 299
Query: 279 ------------DHFVYKGNIPCSSLML-IESTRDSLCFTVTHYKHSKQQYSIQAKTV-- 323
D F ++ IP S+L + + + + ++ H+K + + +T+
Sbjct: 300 SNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQ 359
Query: 324 ------EEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSS 377
E K N I+ ++ EN I + D P + R P K A S
Sbjct: 360 LCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRV-PVSAKLASSR 418
Query: 378 QDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPS-GRSP 433
+V N E K L +E + ++G + G +E + S+ S G+ P
Sbjct: 419 SLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYP 475
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 76.3 bits (186), Expect = 2e-13
Identities = 87/357 (24%), Positives = 146/357 (40%), Gaps = 42/357 (11%)
Query: 118 SQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 177
+ F +Y+ +C N+ L DK F R QHS L SYL+KPVQR+LK
Sbjct: 1195 ADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLK 1254
Query: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEH--AVRLQEIQSLLIN 235
Y LLL+E+ D+E + + +A+ M VA +IN+M++ +E V Q +
Sbjct: 1255 YPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGT 1314
Query: 236 WKGPDLTTYGELVLEGT-------FRVHRVRN--ERTFFLFDKTLLITKKRG-------- 278
K + GEL++ T + + R E T F+F + +++ K
Sbjct: 1315 EKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLP 1374
Query: 279 ------------DHFVYKGNIPCSSLML-IESTRDSLCFTVTHYKHSKQQYSIQAKTV-- 323
D F ++ IP S+L + + + + ++ H+K + + +T+
Sbjct: 1375 SNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQ 1434
Query: 324 ------EEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRYRCSPERLKKAWSS 377
E K N I+ ++ EN I + D P + R P K A S
Sbjct: 1435 LCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRV-PVSAKLASSR 1493
Query: 378 QDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRSSRRPS-GRSP 433
+V N E K L +E + ++G + G +E + S+ S G+ P
Sbjct: 1494 SLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYP 1550
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 73.6 bits (179), Expect = 1e-12
Identities = 68/263 (25%), Positives = 124/263 (47%), Gaps = 37/263 (14%)
Query: 89 HKLSYLGRVVREIVETERMYVQDLRSIVESQEFDIYTQYCNNYPNSVAALTECMRDKQQA 148
HK +L + + I E +R+ ++ ++ IY YC N P S + E A
Sbjct: 289 HKDFFLAELEKCIQEQDRLAQLFIK---HERKLHIYVWYCQNKPRSEYIVAE-----YDA 340
Query: 149 KFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEEDGFEV--VEDAIDTM 206
F +QE+ Q L L +L+KP+QRI KY LLL++ ++ E+ G E +E A++ M
Sbjct: 341 YFEEVKQEINQR-LTLSDFLIKPIQRITKYQLLLKDFLRY--SEKAGLECSDIEKAVELM 397
Query: 207 TCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFRVHRV-------R 259
V NDM + RLQ + LT G+L+ + TF V +
Sbjct: 398 CLVPKRCNDMM----NLGRLQGFEG--------TLTAQGKLLQQDTFYVIELDAGMQSRT 445
Query: 260 NERTFFLFDKTLLITK--KRGD---HFVYKGNIPCSSLMLIESTRDSLCFTVTHYKHSKQ 314
ER FLF++ ++ ++ ++G +++K +I + L+L E+ + C + + +
Sbjct: 446 KERRVFLFEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSE 505
Query: 315 QYSIQAKTVEEKRNWTHHIKRLI 337
+ +QA + ++ W I +++
Sbjct: 506 RVVLQAANADIQQAWVQDINQVL 528
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 73.2 bits (178), Expect = 1e-12
Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 31/270 (11%)
Query: 91 LSYLGRVVREIVETERMYVQDLRSIVESQEFD----------------IYTQYCNNYPNS 134
+SYL + EI ++M VQ L + E +Y YC N+P++
Sbjct: 134 ISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSA 193
Query: 135 VAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAKHFDEEED 194
V LTE ++ +F + L L + L KP R+ KY LL+E+ +H ++
Sbjct: 194 VNVLTE--HSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHT 251
Query: 195 GFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGELVLEGTFR 254
+ ++ ++ ++ ++++R E + LQ + + NW+G D+ T G +
Sbjct: 252 DRQDIQKSMAAFKNLSAQCQEVRKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVL 309
Query: 255 VH----RVRNERTFFLFDKTLLI--TKKRGDHFVYKGNIPCSSL---MLIESTRDSLCFT 305
+ +NER LF LL+ R F+Y+G +P + + L +S F
Sbjct: 310 IQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFE 369
Query: 306 VTHYKHSKQQYSIQAKTVEEKRNWTHHIKR 335
++ ++ + ++ + W H+++
Sbjct: 370 IS--GSMIERILVSCNNQQDLQEWVEHLQK 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,382,018
Number of Sequences: 37866
Number of extensions: 2936289
Number of successful extensions: 13501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 347
Number of HSP's that attempted gapping in prelim test: 12297
Number of HSP's gapped (non-prelim): 1534
length of query: 1163
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1050
effective length of database: 13,968,660
effective search space: 14667093000
effective search space used: 14667093000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.