Search of human proteins with 51479145

Search of human proteins with 51479145

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
protein 1 [Homo sapiens]
         (1849 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...  3684   0.0  
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...  2654   0.0  
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   232   3e-60
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     198   4e-50
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       198   4e-50
gi|4758968 cytohesin 3 [Homo sapiens]                                 193   1e-48
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     187   8e-47
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       187   8e-47
gi|7019505 cytohesin 4 [Homo sapiens]                                 180   1e-44
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      159   2e-38
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       159   2e-38
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       158   5e-38
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       158   5e-38
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 150   1e-35
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   100   2e-20
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   100   2e-20
gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange p...    99   3e-20
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]     96   2e-19
gi|48928044 F-box only protein 8 [Homo sapiens]                        95   6e-19
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]     92   4e-18
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]       91   1e-17
gi|114326552 MON2 homolog [Homo sapiens]                               86   4e-16
gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens]    38   0.10 
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    37   0.14 
gi|148762982 hypothetical protein LOC387640 [Homo sapiens]             37   0.14 
gi|19923559 EMSY protein [Homo sapiens]                                35   0.68 
gi|157671951 solute carrier family 4, anion exchanger, member 3 ...    35   0.68 
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         34   1.2  
gi|4505143 cytosolic malic enzyme 1 [Homo sapiens]                     34   1.2  
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   33   2.0  

>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange protein
            1 [Homo sapiens]
          Length = 1849

 Score = 3684 bits (9552), Expect = 0.0
 Identities = 1849/1849 (100%), Positives = 1849/1849 (100%)

Query: 1    MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA 60
            MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA
Sbjct: 1    MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKA 60

Query: 61   GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST 120
            GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST
Sbjct: 61   GSSTLPPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDST 120

Query: 121  TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN 180
            TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
Sbjct: 121  TPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN 180

Query: 181  IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE 240
            IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE
Sbjct: 181  IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHE 240

Query: 241  PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ 300
            PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ
Sbjct: 241  PESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQ 300

Query: 301  ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT 360
            ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
Sbjct: 301  ATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT 360

Query: 361  IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ 420
            IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ
Sbjct: 361  IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ 420

Query: 421  KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA 480
            KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA
Sbjct: 421  KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA 480

Query: 481  IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS 540
            IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
Sbjct: 481  IKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS 540

Query: 541  SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM 600
            SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM
Sbjct: 541  SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGM 600

Query: 601  SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN 660
            SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN
Sbjct: 601  SNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETIN 660

Query: 661  RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL 720
            RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
Sbjct: 661  RYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL 720

Query: 721  QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA 780
            QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA
Sbjct: 721  QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSA 780

Query: 781  LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS 840
            LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS
Sbjct: 781  LRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHS 840

Query: 841  PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN 900
            PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
Sbjct: 841  PQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN 900

Query: 901  VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF 960
            VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF
Sbjct: 901  VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAF 960

Query: 961  SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ 1020
            SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ
Sbjct: 961  SVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQ 1020

Query: 1021 KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL 1080
            KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
Sbjct: 1021 KNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL 1080

Query: 1081 TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI 1140
            TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI
Sbjct: 1081 TGTKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAI 1140

Query: 1141 VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC 1200
            VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC
Sbjct: 1141 VDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGC 1200

Query: 1201 NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI 1260
            NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI
Sbjct: 1201 NPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCI 1260

Query: 1261 AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF 1320
            AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF
Sbjct: 1261 AQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSF 1320

Query: 1321 QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR 1380
            QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR
Sbjct: 1321 QDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVR 1380

Query: 1381 GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL 1440
            GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL
Sbjct: 1381 GWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFDNMKL 1440

Query: 1441 PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG 1500
            PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG
Sbjct: 1441 PEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQLARSG 1500

Query: 1501 TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK 1560
            TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK
Sbjct: 1501 TNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEK 1560

Query: 1561 PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK 1620
            PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK
Sbjct: 1561 PLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIK 1620

Query: 1621 CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF 1680
            CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF
Sbjct: 1621 CVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLF 1680

Query: 1681 KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD 1740
            KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD
Sbjct: 1681 KLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMD 1740

Query: 1741 ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA 1800
            ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA
Sbjct: 1741 ESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRFKAHA 1800

Query: 1801 SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ 1849
            SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ
Sbjct: 1801 SFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPEQELGINKQ 1849


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
            factor 2 [Homo sapiens]
          Length = 1785

 Score = 2654 bits (6878), Expect = 0.0
 Identities = 1381/1845 (74%), Positives = 1537/1845 (83%), Gaps = 85/1845 (4%)

Query: 6    KTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTL 65
            +TK+MF++RALEKILADKEVK+  HSQLR+AC+VAL+EIKAE EKQ       + G++  
Sbjct: 5    QTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQ-------RLGTAAP 57

Query: 66   PPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKK 125
            P    K NFIEADKYFLPFELACQSK PR+VSTSLDCLQKLIAYGH+TGNAPDS  PGK+
Sbjct: 58   P----KANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKR 113

Query: 126  LIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLAS 185
            LIDRI+ETIC CFQGPQTDEGVQLQIIKALLTAVTS HIEIHEGT+LQ VRTCYNIYLAS
Sbjct: 114  LIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLAS 173

Query: 186  KNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQ 245
            KNLINQTTAKATLTQMLNVIF RMENQ LQEA+++EK    +     QSPV      SP+
Sbjct: 174  KNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKP----QSPVIQAAAVSPK 229

Query: 246  LRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAE 305
               L                  H+    K     T PE  +D+++ E+ ++++ + +   
Sbjct: 230  FVRLK-----------------HSQAQSKP----TTPEK-TDLTNGEHARSDSGKVSTEN 267

Query: 306  TLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGE--GTTINASADGNIG---- 359
              +  E          ++  Q++V++I+E++V   + +  E  G T      G +     
Sbjct: 268  GDAPRE--RGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQEC 325

Query: 360  TIEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHIL 419
             I  G D EN Q NGI              DDR S+SS D  ES ++ G    A+FSH+L
Sbjct: 326  AIPPGVD-ENSQTNGIA-------------DDRQSLSSADNLES-DAQGHQVAARFSHVL 370

Query: 420  QKDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFIN 479
            QKDAFLVFRSLCKLSMKPL +GPPDPKSHELRSK++SLQLLLS+LQNAGP+FRT+EMFIN
Sbjct: 371  QKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFIN 430

Query: 480  AIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETST 539
            AIKQYLCVALSKNGVSSVP+VFELSL+IFLTLLSNFK HLKMQIEVFFKEIFL ILETST
Sbjct: 431  AIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETST 490

Query: 540  SSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELG 599
            SSF+H+WMVIQTLTRICADAQ VVDIYVNYDCDLNAANIFERLVNDLSKIAQGR   ELG
Sbjct: 491  SSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELG 550

Query: 600  MSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETI 659
            M+ +QELSLRKKGLECLVSILKCMVEWSKD YVNPN QT+LGQE+ ++QE+ + K  +  
Sbjct: 551  MTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMA 610

Query: 660  NRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQY 719
             R  S+ S+EST SSG     TQ +  D+PEQFEV+KQQKEIIE GI+LFNKKPKRGIQ+
Sbjct: 611  RRC-SVTSMESTVSSG-----TQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQF 664

Query: 720  LQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVS 779
            LQEQGMLGT+ EDIAQFLHQEERLDSTQVG+FLGD+ +FNKEVMYAYVDQ DF  K+FVS
Sbjct: 665  LQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVS 724

Query: 780  ALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLH 839
            ALR FLEGFRLPGEAQKIDRLMEKFAARY+ECNQGQTLFASADTAYVLAYSIIMLTTDLH
Sbjct: 725  ALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLH 784

Query: 840  SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQ 899
            SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLS+IY EI GKKI+MKETKELTI TKS+KQ
Sbjct: 785  SPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQ 844

Query: 900  NVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAA 959
            NVASEKQRRLLYNLEMEQMAKTAKALMEAVSH +APFTSATHL+HVRPMFKL WTP LAA
Sbjct: 845  NVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAA 904

Query: 960  FSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEMK 1019
            +S+GLQ+CDDTEVASLCLEGIRCAIRIACIF +QLERDAYVQALARF+LLT SS ITEMK
Sbjct: 905  YSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMK 964

Query: 1020 QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGS 1079
            QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVK RY+SG+ R REGS
Sbjct: 965  QKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGS 1024

Query: 1080 LTGTKDQAPDEFVGLGL---VGGNVDWKQIASIQESIGETSSQSVVVAVDRIFTGSTRLD 1136
            L G    A +EF+GLGL   V G VD +Q+AS QES+GETSSQSVVVAVDRIFTGSTRLD
Sbjct: 1025 LKG-HTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLD 1083

Query: 1137 GNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFN 1196
            GNAIVDFVRWLCAVSMDEL S  HPRMFSLQKIVEISYYNM RIRLQWSRIW VIGDHFN
Sbjct: 1084 GNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFN 1143

Query: 1197 KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMV 1256
            KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMK+NRSPTIRDM 
Sbjct: 1144 KVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMA 1203

Query: 1257 VRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPAT 1316
            +RCIAQMVNSQAANIRSGWKNIF+VFH AASD D +IVELAFQTT HIVT +F+ HFPA 
Sbjct: 1204 IRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAA 1263

Query: 1317 IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDR 1376
            IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIR C KYVS+RP+  +EYTSDDMNVAP DR
Sbjct: 1264 IDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDR 1323

Query: 1377 VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIVFRIFD 1436
            VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMK+YGHT+EKHWWQDLFRIVFRIFD
Sbjct: 1324 VWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFD 1383

Query: 1437 NMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQDNEQL 1496
            NMKLPEQ +EK+EWMTTTCNHALYAICDVFTQ+ E L++VLL D+FAQL WCV+QDNEQL
Sbjct: 1384 NMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQL 1443

Query: 1497 ARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSP 1556
            ARSGTNCLEN+VI NGEKF+ E+WD+TCNC LDIFKTTIPH LLTWRP   E        
Sbjct: 1444 ARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGME------ED 1497

Query: 1557 VSEKPLDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAA 1616
             SEK LD      VD+ D     S+D  P       S ++           +  QKLFA+
Sbjct: 1498 SSEKHLD------VDL-DRQSLSSIDKNPSER--GQSQLSNPTDDSWKGRPYANQKLFAS 1548

Query: 1617 LLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTS 1676
            LLIKCVVQLELIQTIDNIVF+PATSKKEDAE++ AAQ+D +D D+ ++T+DQGMY++++S
Sbjct: 1549 LLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSS 1608

Query: 1677 QQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFR 1736
            Q LFKLLDCL ESH F+KAFNSN EQRT LW+AGFKGKSKPNLLKQETSSLAC LRILFR
Sbjct: 1609 QHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFR 1668

Query: 1737 MYMDESRVSAWEEVQQRLLNVCSEALSYFLTLTSESHREAWTNLLLLFLTKVLKISDNRF 1796
            MY+DE+R  +WEE+QQRLL VCSEAL+YF+T+ SESHREAWT+LLLL LTK LKI+D +F
Sbjct: 1669 MYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKF 1728

Query: 1797 KAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQPPE 1841
            KAHAS YYP LCEIMQFDLIPELRAVLR+FFLRIGVV++I  P E
Sbjct: 1729 KAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEE 1773


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
            exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  232 bits (591), Expect = 3e-60
 Identities = 294/1296 (22%), Positives = 545/1296 (42%), Gaps = 162/1296 (12%)

Query: 75   IEADKYFLPFELACQSKCPR--IVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIE 132
            IE + +  PF    +S+     I   +L  + K ++Y  L     + T  G + +   + 
Sbjct: 59   IEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYA-LIDPTHEGTAEGMENMADAVT 117

Query: 133  TICGCFQGPQTDEGVQLQIIKALLTAV-TSQHIEIHEGTVLQAVRTCYNIYLASK-NLIN 190
                    P +DE V ++I++ L T + T     +   +V + +++C+ I    + + + 
Sbjct: 118  HARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELL 177

Query: 191  QTTAKATLTQMLNVIFARMENQALQEAKQ-----MEKERHRQHHHLLQSPVSHHEPESPQ 245
            + +A+ TL  M+ ++F R+  Q  +E K      M+K + R    +  S     +  SP+
Sbjct: 178  RKSAEHTLVDMVQLLFTRLP-QFKEEPKNYVGTNMKKLKMRAGG-MSDSSKWKKQKRSPR 235

Query: 246  LRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAE 305
                PP+ +  ++   E      T             +  + ISSA +E      A+A  
Sbjct: 236  ----PPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEA-----ASAVV 286

Query: 306  TLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT----- 360
            + S +  L        +E   D+ Q           G  G  T     +   +G      
Sbjct: 287  SPSTDSGLEFSSQTTSKEDLTDLEQP----------GSPGYSTATEPGSS-ELGVPEQPD 335

Query: 361  IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQ 420
            +++G+  E  Q+  +   P  +    S  D   S S +D            G +F+   Q
Sbjct: 336  LQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPR-----GVRFTQSSQ 390

Query: 421  KDAFLV-----------FRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGP 469
            K+   +           FR L  L+       P D  + E+    + L LL   L++A P
Sbjct: 391  KEGTALVPYGLPCIRELFRFLISLT------NPHDRHNSEVMIH-MGLHLLTVALESA-P 442

Query: 470  IFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKE 529
            + +   + +  IK  +C  L +        ++  SL +   L  + + HLK Q+E++ K+
Sbjct: 443  VAQCQTL-LGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKK 501

Query: 530  IFLYI-LETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSK 588
            +   I +E     ++ K M ++ + ++      V ++Y+NYDCD   +N+FE L   LSK
Sbjct: 502  LMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSK 561

Query: 589  IAQGRGSQELGMSNVQELS-----LRKKGLECLVSILKCMVEWSKDQYVNPNSQTTLGQE 643
             A     Q L  +++  L      +      C   +L  + +  K +   P+ +   G  
Sbjct: 562  NAFPVSGQ-LYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTR 620

Query: 644  KPSEQE-----------MSEI---------KHPETINRYGSLNSLESTSSSGIGSYSTQM 683
            + S  E            S+I         + P    + G  +  E+  S     ++ + 
Sbjct: 621  EASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKP 680

Query: 684  SG----TDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPED---IAQF 736
                    +P +   +K +K+++  G + FN+KPK+GIQ+LQE+G+L T P D   +AQ+
Sbjct: 681  PRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLL-TIPMDNTEVAQW 739

Query: 737  LHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQK 796
            L +  RLD   +GEF+  +D+ N +++ ++V    F G     ALR++LE FRLPGEA  
Sbjct: 740  LRENPRLDKKMIGEFV--SDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPV 797

Query: 797  IDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNK---MTKEQYI 853
            I RL+E F  R++ CN     FA++D  + LAY++IML TD H+  V+ +   MT E++ 
Sbjct: 798  IQRLLEAFTERWMNCNGSP--FANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFR 855

Query: 854  KMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQRRLLYNL 913
            K  +G+N  KD  ++ L  +Y+ I  ++I M E +   +             +   ++N+
Sbjct: 856  KNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLV-------------RENYVWNV 902

Query: 914  EMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVA 973
             + + A T + +   V       T++  L+    +F + W P +AA S       +  + 
Sbjct: 903  LLHRGA-TPEGIFLRVP------TASYDLD----LFTMTWGPTIAALSYVFDKSLEETII 951

Query: 974  SLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSS-----GITEMKQKNIDTIKT 1028
               + G R    I+  + +    D  + +L +FT L+  S      +     K     KT
Sbjct: 952  QKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKT 1011

Query: 1029 LITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSLTGTKDQAP 1088
            +  +AH  G+ L   W  I++ + QL  AQL+    K            G ++  +++ P
Sbjct: 1012 VFHLAHRHGDILREGWKNIMEAMLQLFRAQLL---PKAMIEVEDFVDPNGKISLQREETP 1068

Query: 1089 DEFVGLGLVGGNVDWKQIASIQESI--GETSSQSVVVAV----------DRIFTGSTRLD 1136
                G   V   V W  ++  ++S   G ++       V          +++ T S  L 
Sbjct: 1069 SN-RGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECIKQCDPEKMITESKFLQ 1127

Query: 1137 GNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFN 1196
              ++ + ++ L +V+ DE         F L+ ++ I   N  R+      +W+ + DH  
Sbjct: 1128 LESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRV----GCVWQTVRDHLY 1183

Query: 1197 KVGCNPNEDVAIF---AVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIR 1253
             + C   +D       AV  L +L+++ L + E++    Q         +MK +    + 
Sbjct: 1184 HL-CVQAQDFCFLVERAVVGLLRLAIRLLRREEIS---AQVLLSLRILLLMKPSVLSRVS 1239

Query: 1254 DMVVRCIAQMVNSQAANIRSG--WKNIFSVFHLAAS 1287
              V   + +++ + AANI SG  W  +F++     S
Sbjct: 1240 HQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGS 1275



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 47/213 (22%), Positives = 86/213 (40%), Gaps = 40/213 (18%)

Query: 1377 VWVRGWFPILFELSCIINRCKLDVRTRGLT------VMFEIMKTYGHTYEKHWWQDLFRI 1430
            +W   W P+L  ++C+    +  VR + LT      ++ ++ K     +E  + + LF +
Sbjct: 1537 LWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPL 1596

Query: 1431 VFRIFDNMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQ 1490
            + ++ +N+   +        M  T   A   +  VF Q+   LS +L    FA L+  + 
Sbjct: 1597 LTKLLENISPAD-----VGGMEETRMRASTLLSKVFLQH---LSPLLSLSTFAALWLTIL 1648

Query: 1491 QDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTI-----PHAL--LTWR 1543
               ++   +G++ L +  I    K  L + D     T +IF +       P AL  +TW 
Sbjct: 1649 DFMDKYMHAGSSDLLSEAIPESLKNMLLVMD-----TAEIFHSADARGGGPSALWEITWE 1703

Query: 1544 ------PNSGETA--------PPPPSPVSEKPL 1562
                  P+  +          P P  P  +KPL
Sbjct: 1704 RIDCFLPHLRDELFKQTVIQDPMPMEPQGQKPL 1736


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  198 bits (504), Expect = 4e-50
 Identities = 100/211 (47%), Positives = 143/211 (67%), Gaps = 3/211 (1%)

Query: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735
           I   + ++    + E+ + +++ K++   G   FN  PK+GIQ+L E  +L  T EDIAQ
Sbjct: 41  IAEVANEIENLGSTEERKNMQRNKQVA-MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQ 99

Query: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
           FL++ E L+ T +G++LG+ D+FN +V++A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 100 FLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQ 159

Query: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855
           KIDR+ME FA RY +CN G  +F S DT YVL+++IIML T LH+P VK+K T E++I M
Sbjct: 160 KIDRMMEAFAQRYCQCNNG--VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAM 217

Query: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886
           NRGIND  DLPEE L  +Y  I  +   + E
Sbjct: 218 NRGINDGGDLPEELLRNLYESIKNEPFKIPE 248


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  198 bits (504), Expect = 4e-50
 Identities = 100/211 (47%), Positives = 143/211 (67%), Gaps = 3/211 (1%)

Query: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735
           I   + ++    + E+ + +++ K++   G   FN  PK+GIQ+L E  +L  T EDIAQ
Sbjct: 41  IAEVANEIENLGSTEERKNMQRNKQVA-MGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQ 99

Query: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
           FL++ E L+ T +G++LG+ D+FN +V++A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 100 FLYKGEGLNKTAIGDYLGERDEFNIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQ 159

Query: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855
           KIDR+ME FA RY +CN G  +F S DT YVL+++IIML T LH+P VK+K T E++I M
Sbjct: 160 KIDRMMEAFAQRYCQCNNG--VFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAM 217

Query: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886
           NRGIND  DLPEE L  +Y  I  +   + E
Sbjct: 218 NRGINDGGDLPEELLRNLYESIKNEPFKIPE 248


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  193 bits (490), Expect = 1e-48
 Identities = 98/211 (46%), Positives = 142/211 (67%), Gaps = 3/211 (1%)

Query: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735
           I    T++    + E+ +  ++ K+I   G   FN  PK+GIQ+L E  +L ++PED+AQ
Sbjct: 45  IAEVMTEIDNLTSVEESKTTQRNKQIA-MGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQ 103

Query: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
           FL++ E L+ T +G++LG+ D+FN +V+ A+V+ H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 104 FLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQ 163

Query: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855
           KIDR+ME FA+RY  CN G  +F S DT YVL+++IIML T LH+  V++K T E++I M
Sbjct: 164 KIDRMMEAFASRYCLCNPG--VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAM 221

Query: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886
           NRGIN+  DLPEE L  +Y  I  +   + E
Sbjct: 222 NRGINEGGDLPEELLRNLYESIKNEPFKIPE 252


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  187 bits (475), Expect = 8e-47
 Identities = 93/206 (45%), Positives = 140/206 (67%), Gaps = 3/206 (1%)

Query: 681 TQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQE 740
           +++ G +  E  + L++ +++   G   FN  PK+GIQ+L E  +L  TPE+IA+FL++ 
Sbjct: 45  SEVEGLEANEGSKTLQRNRKMA-MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKG 103

Query: 741 ERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRL 800
           E L+ T +G++LG+ ++ N  V++A+VD H+F+  + V ALR FL  FRLPGEAQKIDR+
Sbjct: 104 EGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRM 163

Query: 801 MEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIN 860
           ME FA RY  CN G  +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN
Sbjct: 164 MEAFAQRYCLCNPG--VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGIN 221

Query: 861 DSKDLPEEYLSAIYNEIAGKKISMKE 886
           +  DLPEE L  +Y+ I  +   + E
Sbjct: 222 EGGDLPEELLRNLYDSIRNEPFKIPE 247


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  187 bits (475), Expect = 8e-47
 Identities = 93/206 (45%), Positives = 140/206 (67%), Gaps = 3/206 (1%)

Query: 681 TQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQE 740
           +++ G +  E  + L++ +++   G   FN  PK+GIQ+L E  +L  TPE+IA+FL++ 
Sbjct: 45  SEVEGLEANEGSKTLQRNRKMA-MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKG 103

Query: 741 ERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRL 800
           E L+ T +G++LG+ ++ N  V++A+VD H+F+  + V ALR FL  FRLPGEAQKIDR+
Sbjct: 104 EGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRM 163

Query: 801 MEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIN 860
           ME FA RY  CN G  +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN
Sbjct: 164 MEAFAQRYCLCNPG--VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGIN 221

Query: 861 DSKDLPEEYLSAIYNEIAGKKISMKE 886
           +  DLPEE L  +Y+ I  +   + E
Sbjct: 222 EGGDLPEELLRNLYDSIRNEPFKIPE 247


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  180 bits (456), Expect = 1e-44
 Identities = 93/211 (44%), Positives = 136/211 (64%), Gaps = 3/211 (1%)

Query: 676 IGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQ 735
           I     Q+   ++ E+  + +++KE+   G   FN  P +GIQY  E  +L    +DIA+
Sbjct: 40  IADVFAQIDCFESAEESRMAQKEKELCI-GRKKFNMDPAKGIQYFIEHKLLTPDVQDIAR 98

Query: 736 FLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQ 795
           FL++ E L+ T +G +LG+ D  N +V+ A+VD H+F+  + V ALR FL  FRLPGEAQ
Sbjct: 99  FLYKGEGLNKTAIGTYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQ 158

Query: 796 KIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKM 855
           KIDR+ME FA RY  CN G  +F S DT YVL++SIIML T LH+P V+++   E+++ M
Sbjct: 159 KIDRMMEAFATRYCLCNPG--VFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSM 216

Query: 856 NRGINDSKDLPEEYLSAIYNEIAGKKISMKE 886
           NRGIN+  DLPE+ L  +++ I  +  S+ E
Sbjct: 217 NRGINNGSDLPEDQLRNLFDSIKSEPFSIPE 247


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  159 bits (403), Expect = 2e-38
 Identities = 83/186 (44%), Positives = 120/186 (64%), Gaps = 4/186 (2%)

Query: 705 GIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVM 763
           G++LFNKKP++G+QYL E+G +  TP  +A FL Q + L    +GEFLG+  K FN++V+
Sbjct: 517 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 576

Query: 764 YAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASAD 822
              VD+ DFS  +   ALR F    R+ GEAQK++RL+E F+ RY  CN G    F + D
Sbjct: 577 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 636

Query: 823 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGK 880
           T ++LA++II+L TD++SP VK   KM  E +IK  RG++D +D+P E L  IY  I  +
Sbjct: 637 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 696

Query: 881 KISMKE 886
           ++   E
Sbjct: 697 ELKTNE 702


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  159 bits (403), Expect = 2e-38
 Identities = 83/186 (44%), Positives = 120/186 (64%), Gaps = 4/186 (2%)

Query: 705 GIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVM 763
           G++LFNKKP++G+QYL E+G +  TP  +A FL Q + L    +GEFLG+  K FN++V+
Sbjct: 531 GLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVL 590

Query: 764 YAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASAD 822
              VD+ DFS  +   ALR F    R+ GEAQK++RL+E F+ RY  CN G    F + D
Sbjct: 591 DCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPD 650

Query: 823 TAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGK 880
           T ++LA++II+L TD++SP VK   KM  E +IK  RG++D +D+P E L  IY  I  +
Sbjct: 651 TIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKR 710

Query: 881 KISMKE 886
           ++   E
Sbjct: 711 ELKTNE 716


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  158 bits (399), Expect = 5e-38
 Identities = 91/235 (38%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 657 ETIN---RYGSLNSLESTSSSGI--GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNK 711
           ETIN      S +SL    ++G+   +Y  +   + +   F     Q+     G++LFNK
Sbjct: 502 ETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNK 561

Query: 712 KPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVMYAYVDQH 770
           KP++GIQYL E+G L  TP  +A F+ + + L    +GEFLG+  K FN++V+   VD+ 
Sbjct: 562 KPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEM 621

Query: 771 DFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASADTAYVLAY 829
           DFS  D   ALR F    R+ GEAQK++RL+E F+ RY  CN      F + DT ++LA+
Sbjct: 622 DFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAF 681

Query: 830 SIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
           +II+L TD++SP VK   KM  + +IK  RG+++ +D+P + L  IY  I G+++
Sbjct: 682 AIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGREL 736


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  158 bits (399), Expect = 5e-38
 Identities = 91/235 (38%), Positives = 139/235 (59%), Gaps = 9/235 (3%)

Query: 657 ETIN---RYGSLNSLESTSSSGI--GSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNK 711
           ETIN      S +SL    ++G+   +Y  +   + +   F     Q+     G++LFNK
Sbjct: 707 ETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNK 766

Query: 712 KPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK-FNKEVMYAYVDQH 770
           KP++GIQYL E+G L  TP  +A F+ + + L    +GEFLG+  K FN++V+   VD+ 
Sbjct: 767 KPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEM 826

Query: 771 DFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQT-LFASADTAYVLAY 829
           DFS  D   ALR F    R+ GEAQK++RL+E F+ RY  CN      F + DT ++LA+
Sbjct: 827 DFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAF 886

Query: 830 SIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
           +II+L TD++SP VK   KM  + +IK  RG+++ +D+P + L  IY  I G+++
Sbjct: 887 AIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGREL 941


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  150 bits (379), Expect = 1e-35
 Identities = 87/222 (39%), Positives = 131/222 (59%), Gaps = 10/222 (4%)

Query: 698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDK 757
           +K +   G++LFN  P +GIQ+L  +G +  TP  +A FL Q + L    +GEFLG++ K
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 758 -FNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECN-QGQ 815
            FN++V+   VD+ DFS  +   ALR F    R+ GEAQK++RL+E F+ RY  CN +  
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 816 TLFASADTAYVLAYSIIMLTTDLHSPQVK--NKMTKEQYIKMNRGINDSKDLPEEYLSAI 873
             F + DT ++LA++II+L TD++SP +K   KM  E +I+  RG++D  D+P E +  I
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 874 YNEIAGKKISMKETKELTIPTKSSK-----QNVASEKQRRLL 910
           Y  I  K++   E   +T  TK  K     + V S   RRL+
Sbjct: 528 YERIQQKELKSNE-DHVTYVTKVEKSIVGMKTVLSVPHRRLV 568


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 54/169 (31%), Positives = 98/169 (57%), Gaps = 4/169 (2%)

Query: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792
           +A+ L+Q +R   + V + LG N++F+K V   Y+   DF+G     +LR F + F L G
Sbjct: 54  LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 113

Query: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 114 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171

Query: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI--SMKETKELTIPTKSSKQ 899
           I   +G+N+  D  ++ L A+YN I  +K+  ++ + ++   P++S+++
Sbjct: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 220


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 54/169 (31%), Positives = 98/169 (57%), Gaps = 4/169 (2%)

Query: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792
           +A+ L+Q +R   + V + LG N++F+K V   Y+   DF+G     +LR F + F L G
Sbjct: 588 LAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVG 647

Query: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852
           E Q+ +R++  F+ RY  CN      AS D  + L  +I++L TDLH   +  KMT +++
Sbjct: 648 ETQERERVLIHFSNRYFYCN--PDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705

Query: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI--SMKETKELTIPTKSSKQ 899
           I   +G+N+  D  ++ L A+YN I  +K+  ++ + ++   P++S+++
Sbjct: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSESTEE 754


>gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange
            protein 3 [Homo sapiens]
          Length = 2177

 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 131/653 (20%), Positives = 253/653 (38%), Gaps = 100/653 (15%)

Query: 1186 RIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFL-EKGELANFRFQKDFLRPFEHIM 1244
            R W ++  H  +  C+    V+  AV  +  +  + L +  E  +F F +   RPFE IM
Sbjct: 1205 RCWSLVAPHLVEAACHKERHVSQKAVSFIHDILTEVLTDWNEPPHFHFNEALFRPFERIM 1264

Query: 1245 KRNR-SPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVEL------- 1296
            +       ++D VV  I ++V   +  I+SGW+ +FS            + E        
Sbjct: 1265 QLELCDEDVQDQVVTSIGELVEVCSTQIQSGWRPLFSALETVHGGNKSEMKEYLVGDYSM 1324

Query: 1297 ------------AFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACN----------A 1334
                        AF  T +I   VF     + I      VK L E  C           A
Sbjct: 1325 GKGQAPVFDVFEAFLNTDNIQ--VFANAATSYIMCLMKFVKGLGEVDCKEIGDCAPAPGA 1382

Query: 1335 AFPDTSMEAIRLIRHCAK-------------YVSDR----PQAFKEYTSDD-------MN 1370
               D  + A+  +R C++             ++S R    P+  +E ++         ++
Sbjct: 1383 PSTDLCLPALDYLRRCSQLLAKIYKMPLKPIFLSGRLAGLPRRLQEQSASSEDGIESVLS 1442

Query: 1371 VAPEDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRI 1430
               +D   +  W  +L +L+  ++ C    +   L ++FE+++    T    +   ++ +
Sbjct: 1443 DFDDDTGLIEVWIILLEQLTAAVSNCPRQHQPPTLDLLFELLRDVTKTPGPGF--GIYAV 1500

Query: 1431 VFRIFDNMKLPEQQTEK--AEWMTTTCN--HALYAICDVFTQYL----------EVLSDV 1476
            V  +   M +  +++ K  + W   + N  HA+   C++  +++          E + + 
Sbjct: 1501 VHLLLPVMSVWLRRSHKDHSYWDMASANFKHAIGLSCELVVEHIQSFLHSDIRYESMINT 1560

Query: 1477 LLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTI- 1535
            +L D+F  L  CV +  E ++R G +C+  V++  G  FT E+W   C    D F  T+ 
Sbjct: 1561 MLKDLFELLVACVAKPTETISRVGCSCIRYVLVTAGPVFTEEMWRLACCALQDAFSATLK 1620

Query: 1536 PHALLTWRPNSG-----------ETAPPPPSPVSEKP---LDTISQKSVDIHDSIQPRSV 1581
            P   L    +SG             A P  SP +E     +  ++Q+   +     P++ 
Sbjct: 1621 PVKDLLGCFHSGTESFSGEGCQVRVAAPSSSPSAEAEYWRIRAMAQQVFMLDTQCSPKTP 1680

Query: 1582 DNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATS 1641
            +N   A   S   + E     K      +   F  +++  +    L+Q + +I+      
Sbjct: 1681 NNFDHAQ--SCQLIIELPPDEKPNGHTKKSVSFREIVVSLLSHQVLLQNLYDILL----- 1733

Query: 1642 KKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNE 1701
             +E  +  +  +   +      + +  G  R+++ Q L  + D LL+S+R A+ F+++  
Sbjct: 1734 -EEFVKGPSPGEEKTIQVP---EAKLAGFLRYISMQNLAVIFDLLLDSYRTAREFDTSPG 1789

Query: 1702 QRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRL 1754
             +  L K    G    NL +Q   S       L    +        E+V++ L
Sbjct: 1790 LKCLLKKVSGIG-GAANLYRQSAMSFNIYFHALVCAVLTNQETITAEQVKKVL 1841



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 53/225 (23%), Positives = 105/225 (46%), Gaps = 44/225 (19%)

Query: 16  LEKILA--DKEVKKAHHSQLRKACEVALEEIKA-ETEKQSPPHGEAKAGSSTLPPVKSKT 72
           +E+IL    KE   + +  ++++C  ALE +   +T  + PPH                 
Sbjct: 1   MEEILRKLQKEASGSKYKAIKESCTWALETLGGLDTIVKIPPH----------------- 43

Query: 73  NFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIE 132
             +  +K  LP +LA +SK  ++   +L  +QKL++         DS    K+L+++I+ 
Sbjct: 44  --VLREKCLLPLQLALESKNVKLAQHALAGMQKLLSEERFVSMETDSDE--KQLLNQILN 99

Query: 133 TICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYNIYLAS--KNLIN 190
            +      P  +E +Q++++K LL    +   +++   VL+    C   Y++S  +  IN
Sbjct: 100 AV---KVTPSLNEDLQVEVMKVLLCITYTPTFDLNGSAVLKIAEVCIETYISSCHQRSIN 156

Query: 191 QTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSP 235
            T  +ATL+QML+ +  ++              R RQ + ++++P
Sbjct: 157 -TAVRATLSQMLSDLTLQL--------------RQRQENTIIENP 186



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 17/67 (25%), Positives = 34/67 (50%)

Query: 1770 SESHREAWTNLLLLFLTKVLKISDNRFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLR 1829
            +E+  +AWTN++L  L ++  + D  F A     +P + ++        +R  +R +  R
Sbjct: 2109 AEAQIQAWTNMVLTVLNQIQILPDQTFTALQPAVFPCISQLTCHVTDIRVRQAVREWLGR 2168

Query: 1830 IGVVFQI 1836
            +G V+ I
Sbjct: 2169 VGRVYDI 2175


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 53/192 (27%), Positives = 99/192 (51%), Gaps = 2/192 (1%)

Query: 732 DIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLP 791
           ++A  L++ E    ++V  +L  N+ F++ V   Y+    F G+    ALR FL+   L 
Sbjct: 590 NLASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLS 649

Query: 792 GEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQ 851
           GE Q+ +R++ +F+ R+  CN G  +F S D+ + L  +I++L TDLH   +   M+ ++
Sbjct: 650 GETQERERILYQFSRRFHHCNPG--IFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQE 707

Query: 852 YIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQRRLLY 911
           +I    G+ D  + P+E L A+Y  I  +K+     +E T   + ++ ++ + K  +   
Sbjct: 708 FITNLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFL 767

Query: 912 NLEMEQMAKTAK 923
            L  +    T K
Sbjct: 768 QLAQDPTVPTYK 779


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 95.1 bits (235), Expect = 6e-19
 Identities = 55/179 (30%), Positives = 100/179 (55%), Gaps = 9/179 (5%)

Query: 702 IEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKE 761
           +++G   FN  P  G+ Y   +G+L  +P++IA+F+     L+  ++  +L +     ++
Sbjct: 139 LDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDER----RD 194

Query: 762 VMYAYVDQHDFSGKDFVSALRMFLEGFRLPGE-AQKIDRLMEKFAARYLECNQG--QTLF 818
           V+   V  H+F  +   +ALR F      P E  + ++ L+ KF+ R+  CN    + L 
Sbjct: 195 VLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELG 254

Query: 819 ASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEI 877
            S D  YVL YS+I+L+ DL SP VKNKM+K ++I+  R    ++++ E+++  +Y+ I
Sbjct: 255 LSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 50/150 (33%), Positives = 82/150 (54%), Gaps = 2/150 (1%)

Query: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792
           +A+ L+  E      V   LG N++F++ V   Y+   DFSG     ALR FL+ F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376

Query: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852
           E Q+ +R++  F+ RY +CN   +   S D  + L  ++++L TDLH   +  KM+ +Q+
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDS--TSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQF 434

Query: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
           I     +ND +D  ++ L  +YN I  +K+
Sbjct: 435 IANLDQLNDGQDFAKDLLKTLYNSIKNEKL 464


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 50/150 (33%), Positives = 81/150 (54%), Gaps = 2/150 (1%)

Query: 733 IAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPG 792
           +A+ L++ +      V   LG N+ F+K V   Y+    F+G     ALR+FL+   L G
Sbjct: 561 LAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMG 620

Query: 793 EAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQY 852
           E Q+ +R++  F+ RY +CN      +S D A+ L  ++++L TDLH   +  +MT   +
Sbjct: 621 ETQERERVLAHFSQRYFQCN--PEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678

Query: 853 IKMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
           I    G+ND  D P E L A+Y+ I  +K+
Sbjct: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKL 708


>gi|114326552 MON2 homolog [Homo sapiens]
          Length = 1717

 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 105/486 (21%), Positives = 197/486 (40%), Gaps = 66/486 (13%)

Query: 989  IFSIQLERDAYVQALARFTLLTVS-SGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEI 1047
            +  I    +++ Q +A    L V   G   +  KNI  ++TL+ +AH  G  LG SW  +
Sbjct: 642  VMMISPSSESHQQVVAVGQPLAVQPQGTVMLTSKNIQCMRTLLNLAHCHGAVLGTSWQLV 701

Query: 1048 LKCISQLELAQLIGTGVKPRYISGTVRGREGSLT-GTKDQAPDEFVGLGLVGGNVDWKQI 1106
            L  +  L        G+KP   SG      G+L  G   + P   +   ++    D   I
Sbjct: 702  LATLQHLVWI----LGLKPS--SG------GALKPGRAVEGPSTVLTTAVM---TDLPVI 746

Query: 1107 ASIQESIGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELL----STTHPR 1162
            ++I               + R+F  S  LD  ++   +  LC++S++ +     +   P 
Sbjct: 747  SNI---------------LSRLFESSQYLDDVSLHHLINALCSLSLEAMDMAYGNNKEPS 791

Query: 1163 MFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQL---SM 1219
            +F++ K++E    NM RI +    +W  +  H  +V  +PN  +  +  ++L  L    +
Sbjct: 792  LFAVAKLLETGLVNMHRIEI----LWRPLTGHLLEVCQHPNSRMREWGAEALTSLIKAGL 847

Query: 1220 KFLEKGELA-NFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNI 1278
             F     L+ N R Q   L P + +   N  P IR   + C+ Q++ SQ  ++  GW  +
Sbjct: 848  TFNHDPPLSQNQRLQLLLLNPLKEMSNINH-PDIRLKQLECVLQILQSQGDSLGPGWPLV 906

Query: 1279 FSVFHLAASDQDESIVELAFQTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPD 1338
              V     +DQ ES++  AFQ    +VT  F    P T    Q  V     F  +    +
Sbjct: 907  LGVMGAIRNDQGESLIRTAFQCLQLVVT-DFLPTMPCT--CLQIVVDVAGSFGLHNQELN 963

Query: 1339 TSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----------------W 1382
             S+ +I L+ + + Y   R +  ++  + +   A + +   +G                W
Sbjct: 964  ISLTSIGLLWNISDYFFQRGETIEKELNKE-EAAQQKQAEEKGVVLNRPFHPAPPFDCLW 1022

Query: 1383 FPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQD-LFRIVFRIFDNMKLP 1441
              +  +L  +    +  VR      +F  +  +G   +   W   +++++F + D ++  
Sbjct: 1023 LCLYAKLGELCVDPRPAVRKSAGQTLFSTIGAHGTLLQHSTWHTVIWKVLFHLLDRVRES 1082

Query: 1442 EQQTEK 1447
                +K
Sbjct: 1083 STTADK 1088



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 46/203 (22%), Positives = 96/203 (47%), Gaps = 35/203 (17%)

Query: 41  LEEIKAETEKQSPPHGEA-KAGSSTLPPVKSKTNFIEA------DKYFLPFELACQSKCP 93
           L  +  E +K+ PP  EA ++G   +  + ++   I A       +   PF + C +K P
Sbjct: 21  LRALSLECKKKFPPVKEAAESGIIKVKTIAARNTEILAALKENSSEVVQPFLMGCGTKEP 80

Query: 94  RIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIK 153
           +I    L  +Q+L+++  +      S T    +I+ + + +    +        +L++++
Sbjct: 81  KITQLCLAAIQRLMSHEVV------SETAAGNIINMLWQLMENSLE--------ELKLLQ 126

Query: 154 ALLTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQA 213
            +L  +T+  + +H+  + +A+  C+ ++    N+ N T A AT+ Q++ V+F RM    
Sbjct: 127 TVLVLLTTNTV-VHDEALSKAIVLCFRLHFTKDNITNNTAA-ATVRQVVTVVFERM---- 180

Query: 214 LQEAKQMEKERHRQHHHLLQSPV 236
                  E ERHR    +++ PV
Sbjct: 181 -----VAEDERHRD---IIEQPV 195



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 43/188 (22%), Positives = 79/188 (42%), Gaps = 20/188 (10%)

Query: 421 KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINA 480
           KDA+++F+ LC+L     +D P         ++   L+LL S+L +   +F  ++ F   
Sbjct: 214 KDAYMLFQDLCQLVN---ADAPYWLVGMTEMTRTFGLELLESVLNDFPQVFLQHQEFSFL 270

Query: 481 IKQYLCVALSK-----------NGVSSVPEVFELS-LSIFLTLLSNFKTHLKMQIEVFFK 528
           +K+ +C  + K           +  SS P   E     I + LL      +K    +   
Sbjct: 271 LKERVCPLVIKLFSPNIKFRQGSSTSSSPAPVEKPYFPICMRLLRVVSVLIKQFYSLLVT 330

Query: 529 E--IFLYILETSTSSFDHKWM---VIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLV 583
           E  IFL +L     +   +W+    ++++ R C   Q +     +YD   ++  +F  +V
Sbjct: 331 ECEIFLSLLVKFLDADKPQWLRAVAVESIHRFCVQPQLLRSFCQSYDMKQHSTKVFRDIV 390

Query: 584 NDLSKIAQ 591
           N L    Q
Sbjct: 391 NALGSFIQ 398


>gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens]
          Length = 619

 Score = 37.7 bits (86), Expect = 0.10
 Identities = 40/172 (23%), Positives = 67/172 (38%), Gaps = 28/172 (16%)

Query: 273 DKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNI 332
           DK   DD E ++  +    E E+ E D     E  +  E L D ++  C + P     ++
Sbjct: 138 DKEDDDDDEDDDDEE-DEEEEEEEEEDDDDDTEDFADQENLPDPQDISCHQSPSK-TDHL 195

Query: 333 VEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPGTPISVAYTPSLPDDR 392
            E+  +    D  +  +  A + G++G I D S    ++ N  P          ++PD R
Sbjct: 196 TEKAYSDTPRDFPD--SFQAGSPGHLGVIRDFSIESLLRENLYP--------KANIPDRR 245

Query: 393 LSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPD 444
            S+S            P     F H+   D    F +  +L  +P+  GP D
Sbjct: 246 PSLS------------PFAPDFFPHLWPGD----FGAFAQLPEQPMDSGPLD 281


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 37.4 bits (85), Expect = 0.14
 Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 25/160 (15%)

Query: 258 SQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGE 317
           S+    D D  ++  D +  D ++  + SD S++ N    +D + ++++ S ++     +
Sbjct: 629 SESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSD 688

Query: 318 NHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPG 377
           + D  +       +   +  +    D  + +  N+S D +     D SDS N        
Sbjct: 689 SSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS-DSDSSNSSDSSDSSN-------- 739

Query: 378 TPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSH 417
                           S  S+D+ +S NSS  S  +  S+
Sbjct: 740 ----------------SSDSSDSSDSSNSSDSSDSSDSSN 763



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 29/154 (18%), Positives = 60/154 (38%), Gaps = 2/154 (1%)

Query: 255 DHISQEHEGDLDLHTNDV-DKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVL 313
           D        D D   +D  D S  D ++  N SD S + +    +D + ++++ S +   
Sbjct: 570 DSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS 629

Query: 314 YDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQAN 373
            + ++ D + K      N  +   N    D    +  + S+D +  +    S   +  ++
Sbjct: 630 -ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSD 688

Query: 374 GIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSS 407
               +  S +   S   D     S+D+ +S NS+
Sbjct: 689 SSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN 722



 Score = 33.1 bits (74), Expect = 2.6
 Identities = 27/159 (16%), Positives = 60/159 (37%)

Query: 258 SQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGE 317
           S     D    ++  D S  D ++  + SD  S++++ +++  + ++++ + ++     +
Sbjct: 550 SDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSD 609

Query: 318 NHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPG 377
           + D  +                   D    +  + S   +     D SDS N   +    
Sbjct: 610 SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS 669

Query: 378 TPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFS 416
                + + S  D   S  S+D+ +S NSS  S  +  S
Sbjct: 670 DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSS 708



 Score = 32.0 bits (71), Expect = 5.7
 Identities = 25/145 (17%), Positives = 57/145 (39%), Gaps = 3/145 (2%)

Query: 273 DKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNI 332
           D    + ++  N SD S + N    +D + +++    +       ++  +        N 
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876

Query: 333 VEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPGTPISVAYTPSLPDDR 392
            +   +    D  E +  + S+D +  +  D SDS N   +         + + +  D+ 
Sbjct: 877 SDSSDS---SDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933

Query: 393 LSVSSNDTQESGNSSGPSPGAKFSH 417
            S  S+++ +S +SS  S  +  S+
Sbjct: 934 NSSDSSNSSDSSDSSDSSNSSDSSN 958



 Score = 31.6 bits (70), Expect = 7.5
 Identities = 33/161 (20%), Positives = 63/161 (39%), Gaps = 10/161 (6%)

Query: 258 SQEHEGDLDLHTNDVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGE 317
           S   E      ++D D S   D+   N SD S + N    +D + ++++   ++     +
Sbjct: 696 SNSSESSDSSDSSDSDSSDSSDSSNSNSSD-SDSSNSSDSSDSSNSSDSSDSSDSSNSSD 754

Query: 318 NHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGTIEDGSDSENIQ--ANGI 375
           + D  +       N  +   +    D  + +  N+S   +     D SDS N    +N  
Sbjct: 755 SSDSSDS-----SNSSDSSDSSDSSDSSDSS--NSSDSNDSSNSSDSSDSSNSSDSSNSS 807

Query: 376 PGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFS 416
             +  S +      +   S +S+D+ +S NSS  S  +  S
Sbjct: 808 DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848


>gi|148762982 hypothetical protein LOC387640 [Homo sapiens]
          Length = 908

 Score = 37.4 bits (85), Expect = 0.14
 Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 10/102 (9%)

Query: 225 HRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQDDTEPEN 284
           H  HHH       HH  + PQ  + PP    H  Q H G          +S   D+E  +
Sbjct: 337 HHHHHHHHHHHHHHHRAQPPQQSHHPPH--HHRPQPHLGSF-------PESCSSDSESSS 387

Query: 285 GSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQ 326
            SD  +A +    +  ++++ ++S  E   +GE  + EE+ +
Sbjct: 388 YSD-HAANDSDFGSSLSSSSNSVSSEEEEEEGEEEEEEEEEE 428


>gi|19923559 EMSY protein [Homo sapiens]
          Length = 1322

 Score = 35.0 bits (79), Expect = 0.68
 Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 156 LTAVTSQHIEIHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQ 215
           +TAV S    +   TV Q V T   I +AS  L +  +  +  TQ+L    A+   Q  Q
Sbjct: 352 VTAVVSSTPSVVMSTVAQGVSTSA-IKMASTRLPSPKSLVSAPTQIL----AQFPKQHQQ 406

Query: 216 EAKQM--EKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTNDVD 273
             KQ   + ++  Q      SPVSH +   PQ   LPP     I  + E  + + T  V 
Sbjct: 407 SPKQQLYQVQQQTQQQVAQPSPVSHQQ--QPQQSPLPPGIKPTIQIKQESGVKIITQQVQ 464

Query: 274 KS 275
            S
Sbjct: 465 PS 466


>gi|157671951 solute carrier family 4, anion exchanger, member 3
           isoform 1 [Homo sapiens]
          Length = 1232

 Score = 35.0 bits (79), Expect = 0.68
 Identities = 48/202 (23%), Positives = 70/202 (34%), Gaps = 56/202 (27%)

Query: 218 KQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTNDVDKSLQ 277
           +  E  RH  HH     P+S   P   +LR LPP +  H  ++ + +    T+       
Sbjct: 69  RDFEFHRHTSHH--THHPLSARLPPPHKLRRLPPTSARHTRRKRKKE---KTSAPPSEGT 123

Query: 278 DDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMV 337
              + E G+ +   E E+ E +  + AE +              E  P    Q       
Sbjct: 124 PPIQEEGGAGVDEEEEEEEEEEGESEAEPV--------------EPPPSGTPQ------- 162

Query: 338 NIVVGDMGEGTTINASADGNIGTIEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSS 397
                           A  +IG+ ED S          PG P   A T  LP    SV  
Sbjct: 163 ---------------KAKFSIGSDEDDS----------PGLPGRAAVTKPLP----SVGP 193

Query: 398 N-DTQESGNSSGPSPGAKFSHI 418
           + D     +SS PSP A+ S +
Sbjct: 194 HTDKSPQHSSSSPSPRARASRL 215


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 34.3 bits (77), Expect = 1.2
 Identities = 67/274 (24%), Positives = 113/274 (41%), Gaps = 42/274 (15%)

Query: 558  DAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLV 617
            D +  +  Y  Y   L+ A    R+  D +K  +G G+    M ++Q+       L C  
Sbjct: 892  DYEEAIKYYEQY---LSVAQSLNRM-QDQAKAYRGLGNGHRAMGSLQQ------ALVCFE 941

Query: 618  SILKCMVEWSKDQYVNPNSQTTLG----QEKPSEQEMSEIKHPETINRYGSLNSLESTSS 673
              L    E   + +    +   LG    Q    EQ +S ++    I R     +LES ++
Sbjct: 942  KRLVVAHELG-EAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAA 1000

Query: 674  SGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDI 733
             G+G    QM   D   Q+  L  Q  I E+     N    +G  Y    G LG T E +
Sbjct: 1001 CGLGGVYQQMGEYDTALQYHQLDLQ--IAEE----TNNPTCQGRAY----GNLGLTYESL 1050

Query: 734  AQF----LHQEERLD-STQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGF 788
              F    ++QE+ L  + Q+      ND   K V Y+ + +   + +++  A+    EG 
Sbjct: 1051 GTFERAVVYQEQHLSIAAQM------NDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGL 1104

Query: 789  RLPGEAQKIDRLMEKFAARYLECNQGQTLFASAD 822
            RL   A+++ R  ++   R+     G +L+AS +
Sbjct: 1105 RL---AEQLGRREDEAKIRH---GLGLSLWASGN 1132


>gi|4505143 cytosolic malic enzyme 1 [Homo sapiens]
          Length = 572

 Score = 34.3 bits (77), Expect = 1.2
 Identities = 31/111 (27%), Positives = 56/111 (50%), Gaps = 2/111 (1%)

Query: 573 LNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYV 632
           L A  I +  ++D + + QG G   LG++++  ++L K+GL    +I K  +  SK   V
Sbjct: 282 LAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIV 341

Query: 633 NPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQM 683
              +  T  +EK    E  E+K+ E I +     +L   ++ G G++S Q+
Sbjct: 342 KGRASLTQEKEK-FAHEHEEMKNLEAIVQEIKPTALIGVAAIG-GAFSEQI 390


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 33.5 bits (75), Expect = 2.0
 Identities = 48/257 (18%), Positives = 111/257 (43%), Gaps = 24/257 (9%)

Query: 695  LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLD---STQVGEF 751
            L+Q KE+ +Q   L  +  K+  Q+ +++  +    +DI    H  E LD   +   GE 
Sbjct: 760  LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEM 819

Query: 752  LGDNDKFNK--EVMYAYVDQHDFSGKDFVSALRMFLEGF-----RLPGEAQKIDRLMEKF 804
              +N K ++  + +   V +     +   SAL +  E       +L G  +K ++ ++K 
Sbjct: 820  KKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKK- 878

Query: 805  AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKD 864
             +  + C Q +    +         ++I+     H+ Q + +M +++ I+ N  + D++ 
Sbjct: 879  KSEEVYCLQKELKIKNHSLQETSEQNVIL----QHTLQQQQQMLQQETIR-NGELEDTQT 933

Query: 865  LPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQRRLL--------YNLEME 916
              E+ +S +  E+  ++ S  E          S  + A  K+++++          +EM+
Sbjct: 934  KLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMD 993

Query: 917  QMAKTAKALMEAVSHVQ 933
            Q  +    + + + H++
Sbjct: 994  QYKEELSKMEKEIMHLK 1010


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,878,842
Number of Sequences: 37866
Number of extensions: 2945370
Number of successful extensions: 11231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 11063
Number of HSP's gapped (non-prelim): 222
length of query: 1849
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1732
effective length of database: 13,817,196
effective search space: 23931383472
effective search space used: 23931383472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.